MCID: TNS004
MIFTS: 48

Tonsil Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Tonsil Cancer

MalaCards integrated aliases for Tonsil Cancer:

Name: Tonsil Cancer 12 15
Tonsillar Neoplasms 44 73
Malignant Neoplasm of Palatine Tonsil 12
Malignant Neoplasm of Tonsil, Faucial 12
Malignant Neoplasm of Faucial Tonsil 12
Malignant Tonsillar Tumor 12
Malignant Tumor of Tonsil 12
Malignant Neoplasm Tonsil 73
Tonsillar Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8858
ICD10 33 C09 C09.9
ICD9CM 35 146.0
MeSH 44 D014067
NCIt 50 C7404
SNOMED-CT 68 93937006

Summaries for Tonsil Cancer

MalaCards based summary : Tonsil Cancer, also known as tonsillar neoplasms, is related to tongue cancer and tonsil squamous cell carcinoma. An important gene associated with Tonsil Cancer is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Gene Expression and PI3K-Akt signaling pathway. The drugs Mitogens and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include tonsil, tongue and lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Tonsil Cancer

Diseases related to Tonsil Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 tongue cancer 29.8 CDH1 CDKN2A TP53
2 tonsil squamous cell carcinoma 11.1
3 bile duct adenoma 10.3 CDKN2A KRT7
4 endocervical carcinoma 10.3 CDKN2A KRT7
5 optic nerve sheath meningioma 10.3 CDKN2A KRT5
6 cribriform carcinoma 10.3 KIT KRT7
7 intratubular embryonal carcinoma 10.3 KIT KRT7
8 bladder squamous cell carcinoma 10.3 CDKN2A TP53
9 sensory organ benign neoplasm 10.3 KRT5 KRT7
10 spitz nevus 10.3 CDKN2A TP53
11 bile duct mucoepidermoid carcinoma 10.3 KRT5 KRT7
12 middle ear adenoma 10.3 KRT5 KRT7
13 linitis plastica 10.3 CDH1 KRT7
14 renal pelvis adenocarcinoma 10.3 CDH1 KRT7
15 adenoid squamous cell carcinoma 10.3 CDH1 KRT7
16 ameloblastic carcinoma 10.3 CDKN2A KRT14
17 oncocytic breast carcinoma 10.3 KRT14 KRT7
18 epidermolysis bullosa simplex, localized 10.3 KRT14 KRT5
19 fibroepithelial basal cell carcinoma 10.2 KRT14 TP53
20 balloon cell malignant melanoma 10.2 KRT5 KRT7
21 apocrine adenocarcinoma 10.2 ERBB2 KRT5
22 adenoid basal cell carcinoma 10.2 CDKN2A KIT KRT7
23 lymphoepithelioma-like thymic carcinoma 10.2 CDKN2A KIT KRT5
24 inverted transitional papilloma 10.2 CDKN2A KRT5 KRT7
25 esophageal adenosquamous carcinoma 10.2 CDH1 KRT5
26 cutaneous mucoepidermoid carcinoma 10.2 KRT7 MAML2
27 uterine corpus serous adenocarcinoma 10.2 ERBB2 TP53
28 non-proliferative fibrocystic change of the breast 10.2 ERBB2 TP53
29 jejunal cancer 10.2 KIT KRT7
30 ceruminoma 10.2 KIT KRT5 KRT7
31 epstein-barr virus-associated gastric carcinoma 10.2 CDH1 CDKN2A TNF
32 nasal cavity squamous cell carcinoma 10.2 CDKN2A KRT5 KRT7
33 meningioma, familial 10.2 CDH1 CDKN2A TP53
34 anus cancer 10.2 CDKN2A KRT5 KRT7
35 breast papillomatosis 10.2 CDKN2A ERBB2
36 bladder carcinoma in situ 10.2 CDKN2A KRT7 TP53
37 vulvar disease 10.2 CDKN2A KRT7 TP53
38 nasal cavity adenocarcinoma 10.2 CDKN2A KRT7 TP53
39 glycogen-rich clear cell breast carcinoma 10.2 CDKN2A KRT7 TP53
40 keratinizing squamous cell carcinoma 10.2 CDKN2A KRT5 TP53
41 endocervical adenocarcinoma 10.2 CDKN2A KRT7 TP53
42 upper respiratory tract disease 10.2 CDKN2A TNF TP53
43 biliary tract neoplasm 10.2 CDKN2A KRT7 TP53
44 vulva cancer 10.1 CDKN2A KRT7 TP53
45 optic nerve neoplasm 10.1 CDKN2A KRT5 TP53
46 malignant spiradenoma 10.1 KRT5 KRT7 TP53
47 pancreatic ductal carcinoma 10.1 CDKN2A KRT7 TP53
48 lymphoepithelioma-like carcinoma 10.1 CDH1 KRT5 KRT7
49 leukocyte disease 10.1 KIT TNF TP53
50 tongue disease 10.1 CDH1 CDKN2A TP53

Comorbidity relations with Tonsil Cancer via Phenotypic Disease Network (PDN):


Protein-Energy Malnutrition Swallowing Disorders

Graphical network of the top 20 diseases related to Tonsil Cancer:



Diseases related to Tonsil Cancer

Symptoms & Phenotypes for Tonsil Cancer

GenomeRNAi Phenotypes related to Tonsil Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.86 CDH1 CDKN1B CDKN2A CYLD KIT
2 Decreased viability GR00221-A-2 9.86 CYLD
3 Decreased viability GR00221-A-3 9.86 CDKN2A
4 Decreased viability GR00221-A-4 9.86 CDKN2A
5 Decreased viability GR00301-A 9.86 CDH1 CYLD KIT
6 Decreased viability GR00402-S-2 9.86 CDH1 CDKN1B CDKN2A CYLD KIT
7 Decreased viability in esophageal squamous lineage GR00235-A 9.32 ACCS CDH1 CDKN1B CDKN2A ERBB2 KIT

MGI Mouse Phenotypes related to Tonsil Cancer:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.36 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
2 homeostasis/metabolism MP:0005376 10.36 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
3 digestive/alimentary MP:0005381 10.35 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
4 growth/size/body region MP:0005378 10.35 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
5 behavior/neurological MP:0005386 10.33 CDKN1B CDKN2A CYLD ERBB2 KIT KRT5
6 endocrine/exocrine gland MP:0005379 10.33 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
7 integument MP:0010771 10.26 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
8 craniofacial MP:0005382 10.23 CDKN1B ERBB2 KIT KRT14 KRT5 NFIB
9 hematopoietic system MP:0005397 10.22 CDKN1B CDKN2A CYLD KIT KRT14 MTA1
10 mortality/aging MP:0010768 10.21 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
11 immune system MP:0005387 10.19 CDH1 CDKN1B CDKN2A CYLD KIT KRT14
12 embryo MP:0005380 10.16 CDH1 CDKN1B CDKN2A ERBB2 KIT SNAI2
13 neoplasm MP:0002006 10.06 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
14 limbs/digits/tail MP:0005371 10 CYLD ERBB2 KIT KRT5 MTA1 TNF
15 reproductive system MP:0005389 9.96 CDH1 CDKN1B CDKN2A ERBB2 KIT KRT14
16 no phenotypic analysis MP:0003012 9.91 CDH1 CDKN1B CDKN2A KIT KRT5 TNF
17 respiratory system MP:0005388 9.81 CDKN1B CDKN2A CYLD ERBB2 KIT KRT14
18 pigmentation MP:0001186 9.8 CDKN1B CDKN2A KIT KRT14 SNAI2 TP53
19 skeleton MP:0005390 9.56 CDKN1B CDKN2A ERBB2 KIT MTA1 SNAI2
20 vision/eye MP:0005391 9.28 CDKN1B CDKN2A KIT KRT14 MTA1 NFIB

Drugs & Therapeutics for Tonsil Cancer

Drugs for Tonsil Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitogens Phase 1, Phase 2,Early Phase 1
2 Antibodies Phase 1, Phase 2,Not Applicable
3 Immunoglobulins Phase 1, Phase 2,Not Applicable
4
motexafin gadolinium Investigational Phase 1 156436-89-4 12047567
5 Photosensitizing Agents Phase 1
6 Dermatologic Agents Phase 1
7
Bevacizumab Approved, Investigational Early Phase 1 216974-75-3
8
Cisplatin Approved Early Phase 1 15663-27-1 2767 441203 84093
9 Angiogenesis Modulating Agents Early Phase 1
10
Erlotinib Hydrochloride Early Phase 1 183319-69-9 176871
11 Angiogenesis Inhibitors Early Phase 1
12 Endothelial Growth Factors Early Phase 1
13 Protein Kinase Inhibitors Early Phase 1
14 Brimonidine Tartrate Not Applicable 70359-46-5

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene Recruiting NCT03602079 Phase 1, Phase 2 A166
2 Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer Recruiting NCT03224000 Phase 2
3 Motexafin Gadolinium With Chemotherapy and Radiation Therapy for the Treatment of Advanced Head and Neck Cancer Terminated NCT00080028 Phase 1 Motexafin Gadolinium Injection
4 Angiogenic and EGFR Blockade With Curative Chemoradiation for Advanced Head and Neck Cancer Completed NCT00140556 Early Phase 1 Cisplatin;Bevacizumab;Erlotinib
5 New Modalities for Detection of Oropharyngeal Cancer Active, not recruiting NCT03226613 Not Applicable

Search NIH Clinical Center for Tonsil Cancer

Cochrane evidence based reviews: tonsillar neoplasms

Genetic Tests for Tonsil Cancer

Anatomical Context for Tonsil Cancer

MalaCards organs/tissues related to Tonsil Cancer:

41
Tonsil, Tongue, Lung, Ovary, Prostate, Cervix, Salivary Gland

Publications for Tonsil Cancer

Articles related to Tonsil Cancer:

(show all 46)
# Title Authors Year
1
Base of tongue cancer-is it tongue cancer located at the base of the tongue, or is it a type of lingual tonsil cancer? The perspective from a genomic analysis. ( 29452725 )
2018
2
Differentiating Tonsil Cancer from Benign Tonsillar Hypertrophy. ( 29605393 )
2018
3
Pediatric Tonsil Cancer: A National and Institutional Perspective. ( 29571929 )
2018
4
A Taiwanese population-based study on the association between chronic tonsillitis and tonsil cancer. ( 29484140 )
2018
5
Multimodality Treatment of Early-Stage Tonsil Cancer. ( 28669307 )
2017
6
Triple-modality treatment in patients with advanced stage tonsil cancer. ( 28440876 )
2017
7
Staging Neck Dissection and Transoral Robotic Surgery Treatment Algorithm in Palatine Tonsil Cancer. ( 29160154 )
2017
8
Chemoradiotherapy versus surgery followed by postoperative radiotherapy in tonsil cancer: Korean Radiation Oncology Group (KROG) study. ( 28854890 )
2017
9
Coexisting osseous choristoma mimicking advanced stage disease in a tonsil cancer patient: a case report. ( 27567988 )
2016
10
Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: Updated results of an institutional clinical management approach. ( 25868716 )
2015
11
Composition of inflammatory cells regulating the response to concurrent chemoradiation therapy for HPV (+) tonsil cancer. ( 26475063 )
2015
12
TNF-I+ evaluation in tonsil cancer. ( 25826493 )
2015
13
Histogram Analysis of Apparent Diffusion Coefficients for Occult Tonsil Cancer in Patients with Cervical Nodal Metastasis from an Unknown Primary Site at Presentation. ( 26115452 )
2015
14
Analysis of Charges Associated with Definitive Nonsurgical Therapy for Early-Stage Lateralized Tonsil Cancer. ( 25519929 )
2014
15
Robotic approaches to the pharynx: tonsil cancer. ( 24882794 )
2014
16
Human papillomavirus infection is rare in nonmalignant tonsil tissue in the UK: implications for tonsil cancer precursor lesions. ( 24723209 )
2014
17
Extent of local invasion and safe resection in cT1-2 tonsil cancer. ( 23129069 )
2013
18
In Reply to Geropantas et al. Re: Unilateral radiotherapy for the treatment of tonsil cancer. ( 23236999 )
2013
19
p16 immunohistochemistry alone is a better prognosticator in tonsil cancer than human papillomavirus in situ hybridization with or without p16 immunohistochemistry. ( 23130632 )
2013
20
Reduced impact of nodal metastases as a prognostic factor for tonsil cancer in the HPV era. ( 24190760 )
2013
21
Oncologic benefit of tonsillectomy in stage I and II tonsil cancer: a surveillance epidemiology and end results database review. ( 23599071 )
2013
22
Long-term results of ipsilateral radiotherapy for tonsil cancer. ( 23865002 )
2013
23
In Regard to Chronowski et al. Re: Unilateral radiotherapy for the treatment of tonsil cancer. ( 23236997 )
2013
24
Reply, contralateral irradiation for T(limited)N2bM0 lateralized tonsil cancer. ( 23386559 )
2013
25
Patients perceive tonsil cancer as a strike at psycho-socially "vital organs". ( 22951199 )
2012
26
The Prognostic Role of p16 Expression in Tonsil Cancer Treated by Either Surgery or Radiation. ( 23205225 )
2012
27
Can the transoral approach secure a cancer-free deep margin in tonsil cancer? ( 22366439 )
2012
28
Improved survival among patients with base of tongue and tonsil cancer in the United States. ( 22101504 )
2012
29
Unilateral radiotherapy for the treatment of tonsil cancer. ( 22019242 )
2012
30
Definitive Radiotherapy versus Postoperative Radiotherapy for Tonsil Cancer. ( 23341786 )
2012
31
Relationships between metastasis-associated protein (MTA) 1 and lymphatic metastasis in tonsil cancer. ( 21240515 )
2011
32
Mixture cure model with random effects for the analysis of a multi-center tonsil cancer study. ( 21213339 )
2011
33
Pattern of cervical lymph node metastasis in tonsil cancer: predictive factor analysis of contralateral and retropharyngeal lymph node metastasis. ( 21680228 )
2011
34
A 20-year retrospective study of tonsil cancer incidence and survival trends in South East England: 1987-2006. ( 21696555 )
2011
35
Unilateral radiotherapy for tonsil cancer: potential dose distribution optimization with a simple two-field intensity-modulated radiation therapy beam arrangement. ( 20022393 )
2010
36
Value of intraoperative ultrasonography in tonsil cancer. ( 24376925 )
2010
37
Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: results of a prospective management approach. ( 19168295 )
2009
38
Glioblastoma in a patient with early-stage tonsil cancer. ( 17602090 )
2007
39
Targeted intra-arterial chemoradiation for advanced tonsil cancer. ( 16360508 )
2005
40
Is ipsilateral radiation for tonsil cancer with limited tongue extension or T2N1 tonsil cancer without tongue involvement appropriate? ( 12183007 )
2002
41
Management of tonsil cancer. ( 10487954 )
1999
42
Tonsil cancer and Sweet's syndrome. ( 9852556 )
1998
43
Tonsil cancer. Patterns of failure after surgery alone and surgery combined with postoperative radiation therapy. ( 8174064 )
1994
44
Tonsil cancer. ( 2656893 )
1989
45
Tongue and tonsil cancer: staging with US. ( 3511504 )
1986
46
Surgery or radiotherapy for tonsil cancer? ( 13934296 )
1963

Variations for Tonsil Cancer

Expression for Tonsil Cancer

Search GEO for disease gene expression data for Tonsil Cancer.

Pathways for Tonsil Cancer

Pathways related to Tonsil Cancer according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 CDKN1B CDKN2A ERBB2 KIT MAML2 MTA1
2
Show member pathways
12.72 CDKN1B ERBB2 KIT MAML2 TNF TP53
3
Show member pathways
12.59 CDH1 CDKN1B CDKN2A ERBB2 KIT TP53
4
Show member pathways
12.53 CDH1 CDKN1B CDKN2A ERBB2 TP53
5 12.45 CDH1 CDKN1B CDKN2A ERBB2 KIT TP53
6
Show member pathways
12.39 CDH1 CDKN1B ERBB2 TP53
7 12.34 CDKN1B CDKN2A ERBB2 TP53
8
Show member pathways
12.3 CDH1 CDKN1B CDKN2A ERBB2 KIT TP53
9 12.16 CDH1 CDKN1B CDKN2A TP53
10 11.81 CDKN1B CDKN2A TP53
11
Show member pathways
11.79 KRT14 KRT5 KRT7
12 11.78 CDKN1B CDKN2A TP53
13 11.68 CDKN1B CDKN2A ERBB2 TP53
14 11.65 KRT14 KRT5 TP53
15 11.58 CDH1 KIT TNF
16 11.56 CDKN2A ERBB2 TP53
17 11.54 CDH1 ERBB2 SNAI2
18 11.47 ERBB2 KIT TP53
19 11.32 CDKN2A TNF TP53
20 11.12 CDH1 CDKN2A ERBB2 TP53
21 10.74 ERBB2 MYBL1 NFIB TP53

GO Terms for Tonsil Cancer

Cellular components related to Tonsil Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 8.8 KRT14 KRT5 KRT7

Biological processes related to Tonsil Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.99 CDKN2A MAML2 MYBL1 NFIB TNF TP53
2 positive regulation of transcription, DNA-templated GO:0045893 9.88 CDH1 CDKN2A MYBL1 TNF TP53
3 negative regulation of apoptotic process GO:0043066 9.77 CDKN1B ERBB2 KIT SNAI2 TP53
4 cornification GO:0070268 9.67 KRT14 KRT5 KRT7
5 positive regulation of gene expression GO:0010628 9.55 CDKN2A ERBB2 KIT TNF TP53
6 negative regulation of phosphorylation GO:0042326 9.52 CDKN1B CDKN2A
7 cellular response to lithium ion GO:0071285 9.46 CDH1 CDKN1B
8 replicative senescence GO:0090399 9.43 CDKN2A TP53
9 positive regulation of MAP kinase activity GO:0043406 9.43 ERBB2 KIT TNF
10 hemidesmosome assembly GO:0031581 9.4 KRT14 KRT5
11 somatic stem cell division GO:0048103 9.32 CDKN2A KIT
12 negative regulation of immature T cell proliferation in thymus GO:0033088 8.96 CDKN2A ERBB2
13 regulation of branching involved in salivary gland morphogenesis GO:0060693 8.62 SNAI2 TNF

Molecular functions related to Tonsil Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 KIT TNF TP53
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.96 CDKN1B CDKN2A
3 protein phosphatase binding GO:0019903 8.8 CDKN1B ERBB2 TP53

Sources for Tonsil Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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