MCID: TNS004
MIFTS: 35

Tonsil Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Tonsil Cancer

MalaCards integrated aliases for Tonsil Cancer:

Name: Tonsil Cancer 12 15
Tonsillar Neoplasms 44 73
Malignant Neoplasm of Palatine Tonsil 12
Malignant Neoplasm of Tonsil, Faucial 12
Malignant Neoplasm of Faucial Tonsil 12
Malignant Tonsillar Tumor 12
Malignant Tumor of Tonsil 12
Malignant Neoplasm Tonsil 73
Tonsillar Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8858
ICD10 33 C09 C09.9
ICD9CM 35 146.0
MeSH 44 D014067
NCIt 50 C7404

Summaries for Tonsil Cancer

MalaCards based summary : Tonsil Cancer, also known as tonsillar neoplasms, is related to tonsil squamous cell carcinoma and tonsillitis. An important gene associated with Tonsil Cancer is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Amoebiasis and Dendritic Cells Developmental Lineage Pathway. The drugs motexafin gadolinium and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include tonsil, tongue and endothelial.

Related Diseases for Tonsil Cancer

Graphical network of the top 20 diseases related to Tonsil Cancer:



Diseases related to Tonsil Cancer

Symptoms & Phenotypes for Tonsil Cancer

Drugs & Therapeutics for Tonsil Cancer

Drugs for Tonsil Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
motexafin gadolinium Investigational Phase 1 156436-89-4 12047567
2 Dermatologic Agents Phase 1
3 Photosensitizing Agents Phase 1
4
Cisplatin Approved Early Phase 1 15663-27-1 84093 441203 2767
5
Bevacizumab Approved, Investigational Early Phase 1 216974-75-3
6
Menthol Approved Not Applicable 2216-51-5 16666
7
Erlotinib Hydrochloride Early Phase 1 183319-69-9 176871
8 Mitogens Early Phase 1
9 Angiogenesis Inhibitors Early Phase 1
10 Angiogenesis Modulating Agents Early Phase 1
11 Endothelial Growth Factors Early Phase 1
12 Protein Kinase Inhibitors Early Phase 1
13 Brimonidine Tartrate Not Applicable 70359-46-5
14 Antibodies Not Applicable
15 Immunoglobulins Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer Recruiting NCT03224000 Phase 2
2 Motexafin Gadolinium With Chemotherapy and Radiation Therapy for the Treatment of Advanced Head and Neck Cancer Terminated NCT00080028 Phase 1 Motexafin Gadolinium Injection
3 Angiogenic and EGFR Blockade With Curative Chemoradiation for Advanced Head and Neck Cancer Completed NCT00140556 Early Phase 1 Cisplatin;Bevacizumab;Erlotinib
4 New Modalities for Detection of Oropharyngeal Cancer Recruiting NCT03226613 Not Applicable

Search NIH Clinical Center for Tonsil Cancer

Cochrane evidence based reviews: tonsillar neoplasms

Genetic Tests for Tonsil Cancer

Anatomical Context for Tonsil Cancer

MalaCards organs/tissues related to Tonsil Cancer:

41
Tonsil, Tongue, Endothelial, Lymph Node

Publications for Tonsil Cancer

Articles related to Tonsil Cancer:

(show all 47)
# Title Authors Year
1
Base of tongue cancer-is it tongue cancer located at the base of the tongue, or is it a type of lingual tonsil cancer? The perspective from a genomic analysis. ( 29452725 )
2018
2
Differentiating Tonsil Cancer from Benign Tonsillar Hypertrophy. ( 29605393 )
2018
3
Pediatric Tonsil Cancer: A National and Institutional Perspective. ( 29571929 )
2018
4
A Taiwanese population-based study on the association between chronic tonsillitis and tonsil cancer. ( 29484140 )
2018
5
Multimodality Treatment of Early-Stage Tonsil Cancer. ( 28669307 )
2017
6
Triple-modality treatment in patients with advanced stage tonsil cancer. ( 28440876 )
2017
7
Staging Neck Dissection and Transoral Robotic Surgery Treatment Algorithm in Palatine Tonsil Cancer. ( 29160154 )
2017
8
Chemoradiotherapy versus surgery followed by postoperative radiotherapy in tonsil cancer: Korean Radiation Oncology Group (KROG) study. ( 28854890 )
2017
9
Coexisting osseous choristoma mimicking advanced stage disease in a tonsil cancer patient: a case report. ( 27567988 )
2016
10
Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: Updated results of an institutional clinical management approach. ( 25868716 )
2015
11
Composition of inflammatory cells regulating the response to concurrent chemoradiation therapy for HPV (+) tonsil cancer. ( 26475063 )
2015
12
TNF-I+ evaluation in tonsil cancer. ( 25826493 )
2015
13
Histogram Analysis of Apparent Diffusion Coefficients for Occult Tonsil Cancer in Patients with Cervical Nodal Metastasis from an Unknown Primary Site at Presentation. ( 26115452 )
2015
14
Analysis of Charges Associated with Definitive Nonsurgical Therapy for Early-Stage Lateralized Tonsil Cancer. ( 25519929 )
2014
15
Robotic approaches to the pharynx: tonsil cancer. ( 24882794 )
2014
16
Human papillomavirus infection is rare in nonmalignant tonsil tissue in the UK: implications for tonsil cancer precursor lesions. ( 24723209 )
2014
17
Extent of local invasion and safe resection in cT1-2 tonsil cancer. ( 23129069 )
2013
18
In Reply to Geropantas et al. Re: Unilateral radiotherapy for the treatment of tonsil cancer. ( 23236999 )
2013
19
p16 immunohistochemistry alone is a better prognosticator in tonsil cancer than human papillomavirus in situ hybridization with or without p16 immunohistochemistry. ( 23130632 )
2013
20
Reduced impact of nodal metastases as a prognostic factor for tonsil cancer in the HPV era. ( 24190760 )
2013
21
Oncologic benefit of tonsillectomy in stage I and II tonsil cancer: a surveillance epidemiology and end results database review. ( 23599071 )
2013
22
Long-term results of ipsilateral radiotherapy for tonsil cancer. ( 23865002 )
2013
23
In Regard to Chronowski et al. Re: Unilateral radiotherapy for the treatment of tonsil cancer. ( 23236997 )
2013
24
Reply, contralateral irradiation for T(limited)N2bM0 lateralized tonsil cancer. ( 23386559 )
2013
25
Patients perceive tonsil cancer as a strike at psycho-socially "vital organs". ( 22951199 )
2012
26
The Prognostic Role of p16 Expression in Tonsil Cancer Treated by Either Surgery or Radiation. ( 23205225 )
2012
27
Can the transoral approach secure a cancer-free deep margin in tonsil cancer? ( 22366439 )
2012
28
Improved survival among patients with base of tongue and tonsil cancer in the United States. ( 22101504 )
2012
29
Unilateral radiotherapy for the treatment of tonsil cancer. ( 22019242 )
2012
30
Definitive Radiotherapy versus Postoperative Radiotherapy for Tonsil Cancer. ( 23341786 )
2012
31
Relationships between metastasis-associated protein (MTA) 1 and lymphatic metastasis in tonsil cancer. ( 21240515 )
2011
32
Mixture cure model with random effects for the analysis of a multi-center tonsil cancer study. ( 21213339 )
2011
33
Pattern of cervical lymph node metastasis in tonsil cancer: predictive factor analysis of contralateral and retropharyngeal lymph node metastasis. ( 21680228 )
2011
34
A 20-year retrospective study of tonsil cancer incidence and survival trends in South East England: 1987-2006. ( 21696555 )
2011
35
Unilateral radiotherapy for tonsil cancer: potential dose distribution optimization with a simple two-field intensity-modulated radiation therapy beam arrangement. ( 20022393 )
2010
36
Value of intraoperative ultrasonography in tonsil cancer. ( 24376925 )
2010
37
Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: results of a prospective management approach. ( 19168295 )
2009
38
Actinomycosis mimicking a tonsillar neoplasm in an elderly diabetic patient. ( 19054599 )
2009
39
Glioblastoma in a patient with early-stage tonsil cancer. ( 17602090 )
2007
40
Targeted intra-arterial chemoradiation for advanced tonsil cancer. ( 16360508 )
2005
41
Is ipsilateral radiation for tonsil cancer with limited tongue extension or T2N1 tonsil cancer without tongue involvement appropriate? ( 12183007 )
2002
42
Management of tonsil cancer. ( 10487954 )
1999
43
Tonsil cancer and Sweet's syndrome. ( 9852556 )
1998
44
Tonsil cancer. Patterns of failure after surgery alone and surgery combined with postoperative radiation therapy. ( 8174064 )
1994
45
Tonsil cancer. ( 2656893 )
1989
46
Tongue and tonsil cancer: staging with US. ( 3511504 )
1986
47
Surgery or radiotherapy for tonsil cancer? ( 13934296 )
1963

Variations for Tonsil Cancer

Expression for Tonsil Cancer

Search GEO for disease gene expression data for Tonsil Cancer.

Pathways for Tonsil Cancer

Pathways related to Tonsil Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.14 SERPINB3 TNF
2 10.82 CD207 TNF
3 10.33 CDKN2A TNF

GO Terms for Tonsil Cancer

Biological processes related to Tonsil Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response GO:0006952 9.37 CD6 TNF
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.32 EDA2R TNF
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.26 EDA2R TNF
4 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.16 CDKN2A TNF
5 positive regulation of JNK cascade GO:0046330 8.96 EDA2R TNF
6 lipopolysaccharide-mediated signaling pathway GO:0031663 8.62 CD6 TNF

Molecular functions related to Tonsil Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 SERPINB3 TNF

Sources for Tonsil Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....