MCID: TNS004
MIFTS: 47

Tonsil Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Tonsil Cancer

MalaCards integrated aliases for Tonsil Cancer:

Name: Tonsil Cancer 12 15 17
Tonsillar Neoplasms 45 74
Malignant Neoplasm of Palatine Tonsil 12
Malignant Neoplasm of Tonsil, Faucial 12
Malignant Neoplasm of Faucial Tonsil 12
Malignant Tonsillar Tumor 12
Malignant Tumor of Tonsil 12
Malignant Neoplasm Tonsil 74
Tonsillar Carcinoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:8858
ICD9CM 36 146.0
MeSH 45 D014067
NCIt 51 C7404
SNOMED-CT 69 93937006
ICD10 34 C09 C09.9

Summaries for Tonsil Cancer

MalaCards based summary : Tonsil Cancer, also known as tonsillar neoplasms, is related to tongue cancer and tonsil squamous cell carcinoma. An important gene associated with Tonsil Cancer is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Gene Expression and PI3K-Akt signaling pathway. The drugs Ipilimumab and nivolumab have been mentioned in the context of this disorder. Affiliated tissues include tonsil, tongue and endothelial, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Tonsil Cancer

Diseases related to Tonsil Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 tongue cancer 29.8 CDH1 CDKN2A TP53
2 tonsil squamous cell carcinoma 11.1
3 tenosynovial giant cell tumor 10.5 CDKN2A SERPINA3
4 optic nerve sheath meningioma 10.5 CDKN2A KRT5
5 bile duct adenoma 10.5 CDKN2A KRT7
6 endocervical carcinoma 10.5 CDKN2A KRT7
7 cribriform carcinoma 10.4 KIT KRT7
8 intratubular embryonal carcinoma 10.4 KIT KRT7
9 bladder squamous cell carcinoma 10.4 CDKN2A TP53
10 spitz nevus 10.4 CDKN2A TP53
11 sensory organ benign neoplasm 10.4 KRT5 KRT7
12 benign mesothelioma 10.4 KRT5 KRT7
13 bile duct mucoepidermoid carcinoma 10.4 KRT5 KRT7
14 middle ear adenoma 10.4 KRT5 KRT7
15 ameloblastic carcinoma 10.4 CDKN2A KRT14
16 large intestine adenocarcinoma 10.4 CDH1 KRT7
17 linitis plastica 10.4 CDH1 KRT7
18 renal pelvis adenocarcinoma 10.4 CDH1 KRT7
19 adenoid squamous cell carcinoma 10.4 CDH1 KRT7
20 vulvar intraepithelial neoplasia 10.4 KRT7 TP53
21 epidermolysis bullosa simplex, localized 10.4 KRT14 KRT5
22 epidermolysis bullosa simplex, autosomal recessive 1 10.4 KRT14 KRT5
23 lichen planopilaris 10.4 KRT14 KRT5
24 oncocytic breast carcinoma 10.4 KRT14 KRT7
25 lacrimal system cancer 10.3 MAML2 NFIB
26 fibroepithelial basal cell carcinoma 10.3 KRT14 TP53
27 lymphoepithelioma-like thymic carcinoma 10.3 CDKN2A KIT KRT5
28 adenoid basal cell carcinoma 10.3 CDKN2A KIT KRT7
29 thyroid lymphoma 10.3 CDKN2A TNF TP53
30 fibrosarcoma of bone 10.3 CDKN2A KIT SERPINA3
31 inverted transitional papilloma 10.3 CDKN2A KRT5 KRT7
32 balloon cell malignant melanoma 10.3 KRT5 KRT7
33 epstein-barr virus-associated gastric carcinoma 10.3 CDH1 CDKN2A TNF
34 ceruminoma 10.3 KIT KRT5 KRT7
35 apocrine adenocarcinoma 10.2 ERBB2 KRT5
36 nasal cavity squamous cell carcinoma 10.2 CDKN2A KRT5 KRT7
37 scrotal carcinoma 10.2 CDKN2A SERPINA3 TP53
38 meningioma, familial 10.2 CDH1 CDKN2A TP53
39 anus cancer 10.2 CDKN2A KRT5 KRT7
40 keratinizing squamous cell carcinoma 10.2 CDKN2A KRT5 TP53
41 esophageal adenosquamous carcinoma 10.2 CDH1 KRT5
42 gastric squamous cell carcinoma 10.2 KRT5 KRT7 SERPINA3
43 bladder carcinoma in situ 10.2 CDKN2A KRT7 TP53
44 upper respiratory tract disease 10.2 CDKN2A TNF TP53
45 vulvar disease 10.2 CDKN2A KRT7 TP53
46 nasal cavity adenocarcinoma 10.2 CDKN2A KRT7 TP53
47 glycogen-rich clear cell breast carcinoma 10.2 CDKN2A KRT7 TP53
48 embryonal sarcoma 10.2 KIT SERPINA3 TP53
49 optic nerve neoplasm 10.2 CDKN2A KRT5 TP53
50 uterine corpus serous adenocarcinoma 10.2 ERBB2 TP53

Comorbidity relations with Tonsil Cancer via Phenotypic Disease Network (PDN):


Protein-Energy Malnutrition Swallowing Disorders

Graphical network of the top 20 diseases related to Tonsil Cancer:



Diseases related to Tonsil Cancer

Symptoms & Phenotypes for Tonsil Cancer

GenomeRNAi Phenotypes related to Tonsil Cancer according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.86 CDH1 CDKN1B CDKN2A CYLD KIT
2 Decreased viability GR00221-A-2 9.86 CYLD
3 Decreased viability GR00221-A-3 9.86 CDKN2A
4 Decreased viability GR00221-A-4 9.86 CDKN2A
5 Decreased viability GR00301-A 9.86 CDH1 CYLD KIT
6 Decreased viability GR00402-S-2 9.86 CDH1 CDKN1B CDKN2A CYLD KIT
7 Decreased viability in esophageal squamous lineage GR00235-A 9.32 ACCS CDH1 CDKN1B CDKN2A ERBB2 KIT

MGI Mouse Phenotypes related to Tonsil Cancer:

47 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.33 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
2 homeostasis/metabolism MP:0005376 10.29 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
3 growth/size/body region MP:0005378 10.27 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
4 behavior/neurological MP:0005386 10.26 CDKN1B CDKN2A CYLD ERBB2 KIT KRT5
5 digestive/alimentary MP:0005381 10.26 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
6 endocrine/exocrine gland MP:0005379 10.25 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
7 integument MP:0010771 10.2 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
8 craniofacial MP:0005382 10.14 CDKN1B ERBB2 KIT KRT14 KRT5 NFIB
9 mortality/aging MP:0010768 10.14 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
10 neoplasm MP:0002006 10.02 CDH1 CDKN1B CDKN2A CYLD ERBB2 KIT
11 limbs/digits/tail MP:0005371 9.98 CYLD ERBB2 KIT KRT5 MTA1 TNF
12 no phenotypic analysis MP:0003012 9.87 CDH1 CDKN1B CDKN2A KIT KRT5 TNF
13 reproductive system MP:0005389 9.81 CDH1 CDKN1B CDKN2A ERBB2 KIT KRT14
14 pigmentation MP:0001186 9.65 CDKN1B CDKN2A KIT KRT14 TP53
15 respiratory system MP:0005388 9.61 CDKN1B CDKN2A CYLD ERBB2 KIT KRT14
16 vision/eye MP:0005391 9.23 CDKN1B CDKN2A KIT KRT14 MTA1 NFIB

Drugs & Therapeutics for Tonsil Cancer

Drugs for Tonsil Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ipilimumab Approved Phase 2 477202-00-9
2
nivolumab Approved Phase 2 946414-94-4
3 Immunoglobulins Phase 1, Phase 2,Phase 2,Not Applicable
4 Antibodies Phase 1, Phase 2,Phase 2,Not Applicable
5 Mitogens Phase 1, Phase 2,Early Phase 1
6 Antineoplastic Agents, Immunological Phase 2,Early Phase 1
7 Antibodies, Monoclonal Phase 2
8
motexafin gadolinium Investigational Phase 1 156436-89-4 12047567
9 Dermatologic Agents Phase 1
10 Photosensitizing Agents Phase 1
11
Bevacizumab Approved, Investigational Early Phase 1 216974-75-3
12
Cisplatin Approved Early Phase 1 15663-27-1 441203 84093 2767
13 Brimonidine Tartrate Not Applicable 70359-46-5
14
Erlotinib Hydrochloride Early Phase 1 183319-69-9 176871
15 Angiogenesis Inhibitors Early Phase 1
16 Protein Kinase Inhibitors Early Phase 1
17 Angiogenesis Modulating Agents Early Phase 1
18 Endothelial Growth Factors Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene Recruiting NCT03602079 Phase 1, Phase 2 A166
2 Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer Recruiting NCT03224000 Phase 2
3 Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma Not yet recruiting NCT03799445 Phase 2
4 Motexafin Gadolinium With Chemotherapy and Radiation Therapy for the Treatment of Advanced Head and Neck Cancer Terminated NCT00080028 Phase 1 Motexafin Gadolinium Injection
5 New Modalities for Detection of Oropharyngeal Cancer Completed NCT03226613 Not Applicable
6 Angiogenic and EGFR Blockade With Curative Chemoradiation for Advanced Head and Neck Cancer Completed NCT00140556 Early Phase 1 Cisplatin;Bevacizumab;Erlotinib
7 Photon Therapy Versus Proton Therapy in Early Tonsil Cancer. Recruiting NCT03829033 Not Applicable

Search NIH Clinical Center for Tonsil Cancer

Cochrane evidence based reviews: tonsillar neoplasms

Genetic Tests for Tonsil Cancer

Anatomical Context for Tonsil Cancer

MalaCards organs/tissues related to Tonsil Cancer:

42
Tonsil, Tongue, Endothelial, Lymph Node

Publications for Tonsil Cancer

Articles related to Tonsil Cancer:

(show all 47)
# Title Authors Year
1
A novel human in vitro papillomavirus type 16 positive tonsil cancer cell line with high sensitivity to radiation and cisplatin. ( 30909875 )
2019
2
Base of tongue cancer-is it tongue cancer located at the base of the tongue, or is it a type of lingual tonsil cancer? The perspective from a genomic analysis. ( 29452725 )
2018
3
Differentiating Tonsil Cancer from Benign Tonsillar Hypertrophy. ( 29605393 )
2018
4
Pediatric Tonsil Cancer: A National and Institutional Perspective. ( 29571929 )
2018
5
A Taiwanese population-based study on the association between chronic tonsillitis and tonsil cancer. ( 29484140 )
2018
6
Multimodality Treatment of Early-Stage Tonsil Cancer. ( 28669307 )
2017
7
Triple-modality treatment in patients with advanced stage tonsil cancer. ( 28440876 )
2017
8
Staging Neck Dissection and Transoral Robotic Surgery Treatment Algorithm in Palatine Tonsil Cancer. ( 29160154 )
2017
9
Chemoradiotherapy versus surgery followed by postoperative radiotherapy in tonsil cancer: Korean Radiation Oncology Group (KROG) study. ( 28854890 )
2017
10
Coexisting osseous choristoma mimicking advanced stage disease in a tonsil cancer patient: a case report. ( 27567988 )
2016
11
Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: Updated results of an institutional clinical management approach. ( 25868716 )
2015
12
Composition of inflammatory cells regulating the response to concurrent chemoradiation therapy for HPV (+) tonsil cancer. ( 26475063 )
2015
13
TNF-I+ evaluation in tonsil cancer. ( 25826493 )
2015
14
Histogram Analysis of Apparent Diffusion Coefficients for Occult Tonsil Cancer in Patients with Cervical Nodal Metastasis from an Unknown Primary Site at Presentation. ( 26115452 )
2015
15
Analysis of Charges Associated with Definitive Nonsurgical Therapy for Early-Stage Lateralized Tonsil Cancer. ( 25519929 )
2014
16
Robotic approaches to the pharynx: tonsil cancer. ( 24882794 )
2014
17
Human papillomavirus infection is rare in nonmalignant tonsil tissue in the UK: implications for tonsil cancer precursor lesions. ( 24723209 )
2014
18
Extent of local invasion and safe resection in cT1-2 tonsil cancer. ( 23129069 )
2013
19
In Reply to Geropantas et al. Re: Unilateral radiotherapy for the treatment of tonsil cancer. ( 23236999 )
2013
20
p16 immunohistochemistry alone is a better prognosticator in tonsil cancer than human papillomavirus in situ hybridization with or without p16 immunohistochemistry. ( 23130632 )
2013
21
Reduced impact of nodal metastases as a prognostic factor for tonsil cancer in the HPV era. ( 24190760 )
2013
22
Oncologic benefit of tonsillectomy in stage I and II tonsil cancer: a surveillance epidemiology and end results database review. ( 23599071 )
2013
23
Long-term results of ipsilateral radiotherapy for tonsil cancer. ( 23865002 )
2013
24
In Regard to Chronowski et al. Re: Unilateral radiotherapy for the treatment of tonsil cancer. ( 23236997 )
2013
25
Reply, contralateral irradiation for T(limited)N2bM0 lateralized tonsil cancer. ( 23386559 )
2013
26
Patients perceive tonsil cancer as a strike at psycho-socially "vital organs". ( 22951199 )
2012
27
The Prognostic Role of p16 Expression in Tonsil Cancer Treated by Either Surgery or Radiation. ( 23205225 )
2012
28
Can the transoral approach secure a cancer-free deep margin in tonsil cancer? ( 22366439 )
2012
29
Improved survival among patients with base of tongue and tonsil cancer in the United States. ( 22101504 )
2012
30
Unilateral radiotherapy for the treatment of tonsil cancer. ( 22019242 )
2012
31
Definitive Radiotherapy versus Postoperative Radiotherapy for Tonsil Cancer. ( 23341786 )
2012
32
Relationships between metastasis-associated protein (MTA) 1 and lymphatic metastasis in tonsil cancer. ( 21240515 )
2011
33
Mixture cure model with random effects for the analysis of a multi-center tonsil cancer study. ( 21213339 )
2011
34
Pattern of cervical lymph node metastasis in tonsil cancer: predictive factor analysis of contralateral and retropharyngeal lymph node metastasis. ( 21680228 )
2011
35
A 20-year retrospective study of tonsil cancer incidence and survival trends in South East England: 1987-2006. ( 21696555 )
2011
36
Unilateral radiotherapy for tonsil cancer: potential dose distribution optimization with a simple two-field intensity-modulated radiation therapy beam arrangement. ( 20022393 )
2010
37
Value of intraoperative ultrasonography in tonsil cancer. ( 24376925 )
2010
38
Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: results of a prospective management approach. ( 19168295 )
2009
39
Glioblastoma in a patient with early-stage tonsil cancer. ( 17602090 )
2007
40
Targeted intra-arterial chemoradiation for advanced tonsil cancer. ( 16360508 )
2005
41
Is ipsilateral radiation for tonsil cancer with limited tongue extension or T2N1 tonsil cancer without tongue involvement appropriate? ( 12183007 )
2002
42
Management of tonsil cancer. ( 10487954 )
1999
43
Tonsil cancer and Sweet's syndrome. ( 9852556 )
1998
44
Tonsil cancer. Patterns of failure after surgery alone and surgery combined with postoperative radiation therapy. ( 8174064 )
1994
45
Tonsil cancer. ( 2656893 )
1989
46
Tongue and tonsil cancer: staging with US. ( 3511504 )
1986
47
Surgery or radiotherapy for tonsil cancer? ( 13934296 )
1963

Variations for Tonsil Cancer

Expression for Tonsil Cancer

Search GEO for disease gene expression data for Tonsil Cancer.

Pathways for Tonsil Cancer

Pathways related to Tonsil Cancer according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.62 CDKN1B CDKN2A ERBB2 KIT MAML2 MTA1
2
Show member pathways
12.72 CDKN1B ERBB2 KIT MAML2 TNF TP53
3
Show member pathways
12.59 CDH1 CDKN1B CDKN2A ERBB2 KIT TP53
4 12.46 CDH1 CDKN1B CDKN2A ERBB2 KIT TP53
5
Show member pathways
12.45 CDH1 CDKN1B CDKN2A ERBB2 TP53
6 12.33 CDKN1B CDKN2A ERBB2 TP53
7
Show member pathways
12.3 CDH1 CDKN1B CDKN2A ERBB2 KIT TP53
8 12.16 CDH1 CDKN1B CDKN2A TP53
9 11.85 CDKN1B TNF TP53
10 11.81 CDKN1B CDKN2A TP53
11
Show member pathways
11.79 KRT14 KRT5 KRT7
12 11.77 CDKN1B CDKN2A TP53
13 11.68 CDKN1B CDKN2A ERBB2 TP53
14 11.64 KRT14 KRT5 TP53
15 11.57 CDH1 KIT TNF
16 11.55 CDKN2A ERBB2 TP53
17 11.47 ERBB2 KIT TP53
18 11.32 CDKN2A TNF TP53
19 11.12 CDH1 CDKN2A ERBB2 TP53
20 10.74 ERBB2 MYBL1 NFIB TP53

GO Terms for Tonsil Cancer

Cellular components related to Tonsil Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 8.8 KRT14 KRT5 KRT7

Biological processes related to Tonsil Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.95 CDKN2A MAML2 MYBL1 NFIB TNF TP53
2 positive regulation of transcription, DNA-templated GO:0045893 9.83 CDH1 CDKN2A MYBL1 TNF TP53
3 cornification GO:0070268 9.63 KRT14 KRT5 KRT7
4 negative regulation of phosphorylation GO:0042326 9.49 CDKN1B CDKN2A
5 cellular response to lithium ion GO:0071285 9.4 CDH1 CDKN1B
6 replicative senescence GO:0090399 9.37 CDKN2A TP53
7 positive regulation of gene expression GO:0010628 9.35 CDKN2A ERBB2 KIT TNF TP53
8 positive regulation of MAP kinase activity GO:0043406 9.33 ERBB2 KIT TNF
9 hemidesmosome assembly GO:0031581 9.32 KRT14 KRT5
10 somatic stem cell division GO:0048103 9.26 CDKN2A KIT
11 negative regulation of immature T cell proliferation in thymus GO:0033088 8.62 CDKN2A ERBB2

Molecular functions related to Tonsil Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 KIT TNF TP53
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.96 CDKN1B CDKN2A
3 protein phosphatase binding GO:0019903 8.8 CDKN1B ERBB2 TP53

Sources for Tonsil Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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