MCID: TNS004
MIFTS: 44

Tonsil Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Tonsil Cancer

MalaCards integrated aliases for Tonsil Cancer:

Name: Tonsil Cancer 12 15 17
Tonsillar Neoplasms 44 70
Malignant Neoplasm of Palatine Tonsil 12
Malignant Neoplasm of Tonsil, Faucial 12
Malignant Neoplasm of Faucial Tonsil 12
Malignant Tonsillar Tumor 12
Malignant Tumor of Tonsil 12
Malignant Neoplasm Tonsil 70
Tonsillar Carcinoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:8858
ICD9CM 34 146.0
MeSH 44 D014067
NCIt 50 C7404
SNOMED-CT 67 93937006
ICD10 32 C09 C09.9
UMLS 70 C0040422 C0558355 C0751560

Summaries for Tonsil Cancer

MalaCards based summary : Tonsil Cancer, also known as tonsillar neoplasms, is related to squamous cell papilloma and papilloma. An important gene associated with Tonsil Cancer is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Gene Expression and PI3K-Akt signaling pathway. The drugs Cisplatin and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include tonsil, tongue and lymph node, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Tonsil Cancer

Diseases related to Tonsil Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 485)
# Related Disease Score Top Affiliating Genes
1 squamous cell papilloma 30.5 TP53 CDKN2A
2 papilloma 30.3 TP53 KRT7 KRT5 ERBB2 CDKN2A CDKN1B
3 diffuse large b-cell lymphoma 30.3 TP53 TNF MIR199A1 CDKN2A
4 oropharynx cancer 30.3 TP53 SERPINA3 PLAG1 NTRK3 NFIB MYBL1
5 lymphoma, non-hodgkin, familial 29.9 TP53 SERPINA3 MIR199A1 H2AC18 ETV6 CDKN1B
6 tonsil squamous cell carcinoma 11.1
7 epstein-barr virus-associated gastric carcinoma 10.5 TNF CDKN2A
8 cervical basaloid squamous cell carcinoma 10.5 KRT7 CDKN2A
9 penile urethral cancer 10.5 KRT5 CDKN2A
10 anal canal paget's disease 10.5 KRT7 CDKN2A
11 male urethral cancer 10.5 KRT5 CDKN2A
12 lacrimal gland mucoepidermoid carcinoma 10.5 MAML2 CRTC1
13 parotid gland adenoid cystic carcinoma 10.5 ERBB2 CDKN2A
14 atrophic vulva 10.5 KRT7 CDKN2A
15 ureter squamous cell carcinoma 10.5 KRT7 KRT5
16 schneiderian carcinoma 10.5 MAML2 CRTC1
17 lymphoepithelioma-like thymic carcinoma 10.5 KRT5 KIT
18 maxillary sinus benign neoplasm 10.5 KIT CDKN2A
19 vulvar intraepithelial neoplasia 10.5 TP53 CDKN2A
20 ureter adenocarcinoma 10.5 KRT7 KRT5
21 vaginal tubulovillous adenoma 10.5 KRT7 CDKN2A
22 subareolar duct papillomatosis 10.5 KRT7 KRT5
23 nipple benign neoplasm 10.5 KRT7 KRT5
24 mucoepidermoid esophageal carcinoma 10.5 TP53 KRT5
25 auditory system benign neoplasm 10.5 KRT7 KRT5
26 tenosynovial giant cell tumor 10.5 SERPINA3 KIT CDKN2A
27 malignant spindle cell melanoma 10.5 SERPINA3 KIT CDKN2A
28 esophagus verrucous carcinoma 10.5 TP53 CDKN2A
29 fibrosarcoma of bone 10.5 SERPINA3 KIT CDKN2A
30 pancreas sarcoma 10.5 SERPINA3 CDKN2A
31 laryngeal small cell carcinoma 10.5 KRT5 KIT CDKN2A
32 pleomorphic liposarcoma 10.5 SERPINA3 KIT CDKN2A
33 microinvasive cervical squamous cell carcinoma 10.5 KRT7 KRT5
34 breast leiomyosarcoma 10.5 KRT7 KIT
35 trachea adenoid cystic carcinoma 10.5 NFIB KRT5 KIT
36 external ear carcinoma 10.5 KRT7 KRT5
37 benign breast adenomyoepithelioma 10.4 KRT7 KRT5
38 breast cystic hypersecretory carcinoma 10.4 KRT5 ERBB2
39 cecal disease 10.4 TNF SERPINA3 KRT7
40 pancreatic foamy gland adenocarcinoma 10.4 TP53 KRT7
41 lipid-rich breast carcinoma 10.4 KRT5 ERBB2
42 cutaneous solitary mastocytoma 10.4 SERPINA3 KIT
43 thyroid lymphoma 10.4 TP53 TNF CDKN2A
44 inverted transitional papilloma 10.4 KRT7 KRT5 CDKN2A
45 intestinal perforation 10.4 TNF SERPINA3 KRT7
46 basaloid lung carcinoma 10.4 TP53 KRT5
47 retroperitoneum carcinoma 10.4 KRT7 KIT CDKN2A
48 human papillomavirus infectious disease 10.4 TP53 CDKN2A
49 papillary squamous carcinoma 10.4 KRT7 KRT5 CDKN2A
50 lacrimal gland adenocarcinoma 10.4 NFIB MYBL1

Comorbidity relations with Tonsil Cancer via Phenotypic Disease Network (PDN):


Protein-Energy Malnutrition Swallowing Disorders

Graphical network of the top 20 diseases related to Tonsil Cancer:



Diseases related to Tonsil Cancer

Symptoms & Phenotypes for Tonsil Cancer

MGI Mouse Phenotypes related to Tonsil Cancer:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.32 CDKN1B CDKN2A CRTC1 ERBB2 KIT KRT5
2 growth/size/body region MP:0005378 10.25 CDKN1B CDKN2A CRTC1 ERBB2 ETV6 KIT
3 homeostasis/metabolism MP:0005376 10.25 CDKN1B CDKN2A CRTC1 ERBB2 ETV6 KIT
4 endocrine/exocrine gland MP:0005379 10.2 CDKN1B CDKN2A CRTC1 ERBB2 ETV6 KIT
5 digestive/alimentary MP:0005381 10.13 CDKN1B CDKN2A ERBB2 ETV6 KIT KRT5
6 craniofacial MP:0005382 10.1 CDKN1B ERBB2 KIT KRT5 NFIB PLAG1
7 integument MP:0010771 10.07 CDKN1B CDKN2A ERBB2 ETV6 KIT KRT5
8 limbs/digits/tail MP:0005371 9.87 ERBB2 KIT KRT5 MTA1 PLAG1 TNF
9 neoplasm MP:0002006 9.8 CDKN1B CDKN2A ERBB2 ETV6 KIT TNF
10 no phenotypic analysis MP:0003012 9.7 CDKN1B CDKN2A ETV6 KIT NTRK3 TNF
11 reproductive system MP:0005389 9.65 CDKN1B CDKN2A CRTC1 ERBB2 KIT MYBL1
12 respiratory system MP:0005388 9.23 CDKN1B CDKN2A ERBB2 KIT NFIB NTRK3

Drugs & Therapeutics for Tonsil Cancer

Drugs for Tonsil Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
2
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
3
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
4 Antimitotic Agents Phase 2
5 Tubulin Modulators Phase 2
6 Mitogens Phase 1, Phase 2
7 Antibodies Phase 1, Phase 2
8 Immunoglobulins Phase 1, Phase 2
9
Bevacizumab Approved, Investigational Early Phase 1 216974-75-3
10 Angiogenesis Inhibitors Early Phase 1
11 Antineoplastic Agents, Immunological Early Phase 1
12
Erlotinib Hydrochloride Early Phase 1 183319-69-9 176871
13 Endothelial Growth Factors Early Phase 1
14 Protein Kinase Inhibitors Early Phase 1
15 Brimonidine Tartrate 70359-46-5

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study: Induction Chemotherapy Followed by Transoral Robotic Surgery and Neck Dissection for Definitive Management of Oropharyngeal Squamous Cell Carcinoma. (NECTORS Trial) Recruiting NCT04277858 Phase 2 Docetaxel
2 A Phase I-II, FIH Study of A166 in Locally Advanced/Metastatic Solid Tumors Expressing Human Epidermal Growth Factor Receptor 2 (HER2) or Are HER2 Amplified That Did Not Respond or Stopped Responding to Approved Therapies Recruiting NCT03602079 Phase 1, Phase 2 A166
3 Concurrent Angiogenic and EGFR Blockade in Conjunction With Curative Intent Chemoradiation for Locally Advanced Head and Neck Cancer Completed NCT00140556 Early Phase 1 Cisplatin;Bevacizumab;Erlotinib
4 Advancing New Modalities for the Detection of Oropharyngeal Cancer: Transcervical Ultrasound and HPV16 E6 Antibodies Completed NCT03226613
5 Photon Therapy Versus Proton Therapy in Early Tonsil Cancer. Recruiting NCT03829033

Search NIH Clinical Center for Tonsil Cancer

Cochrane evidence based reviews: tonsillar neoplasms

Genetic Tests for Tonsil Cancer

Anatomical Context for Tonsil Cancer

MalaCards organs/tissues related to Tonsil Cancer:

40
Tonsil, Tongue, Lymph Node, Endothelial, Colon

Publications for Tonsil Cancer

Articles related to Tonsil Cancer:

(show top 50) (show all 151)
# Title Authors PMID Year
1
Tonsillectomy as a Prevention Strategy in the Light of Increasing Incidence of Oropharyngeal Cancer - a Research of Current Literature. 61
33788706 2021
2
Determination of posterolateral oropharyngeal wall thickness and the potential implications for transoral surgical margins in tonsil cancer. 61
33780072 2021
3
The emergence of oral cavity cancer and the stabilization of oropharyngeal cancer: Recent contrasting epidemics in the South Korean population. 61
33595858 2021
4
Is the retropharyngeal lymph node the first echelon node for carcinoma tonsil? Prospective evaluation and literature review. 61
33417147 2021
5
Treatment of Early Stage Tonsil Cancer in the Age of Human Papillomavirus-Associated Malignancies. 61
33290171 2020
6
[Application of submental artery perforator flap in reconstruction surgery in pharyngeal carcinoma]. 61
33342127 2020
7
Organised hematoma mimicking sino-nasal malignancy in patients post-radiotherapy. 61
33184013 2020
8
Periodontitis in tonsil cancer patients-A comparative study in accordance with tumour p16 status. 61
32450010 2020
9
Google Trends application for the study of information search behaviour on oropharyngeal cancer in Spain. 61
33237476 2020
10
Increasing prevalence of HPV in oropharyngeal carcinoma suggests adaptation of p16 screening in Southeast Asia. 61
32932151 2020
11
A Dosimetric Comparison of Oral Cavity Sparing in the Unilateral Treatment of Early Stage Tonsil Cancer: IMRT, IMPT, and Tongue-Deviating Oral Stents. 61
33305099 2020
12
Prognostic impact of resection margin involvement in surgically managed HPV-positive tonsil cancer. 61
32447243 2020
13
Spontaneous Tonsillar Hemorrhage due to Infectious Mononucleosis. 61
33062490 2020
14
Primary Closure With Posteriorly Based Lateral Tongue Flap Reconstruction After Transoral Videolaryngoscopic Surgery for Tonsil Cancer. 61
32813988 2020
15
Identification of antigen-specific neutrophils in the tonsils with recurrent acute inflammation. 61
32525408 2020
16
Presurgical induction chemotherapy for squamous cell carcinoma of the tonsil. 61
31318046 2020
17
Comparative cost of transoral robotic surgery and radiotherapy (IMRT) in early stage tonsil cancer. 61
32057489 2020
18
Unexpected occult malignancy diagnosed during tonsillectomy surgery for obstructive sleep apnea: A case report. 61
32358351 2020
19
Childhood tonsillectomy alters the primary distribution of HPV-related oropharyngeal squamous cell carcinoma. 61
32337351 2020
20
Patient-reported quality of life and toxicity in unilateral and bilateral radiotherapy for early-stage human papillomavirus associated tonsillar carcinoma. 61
32072029 2020
21
[Safety and effectiveness of transoral robotic surgery for oropharyngeal cancer: a pilot study]. 61
32074748 2020
22
Risk of post-operative, pre-radiotherapy contralateral neck recurrence in patients treated with surgery followed by adjuvant radiotherapy for human papilloma virus-associated tonsil cancer. 61
31600090 2019
23
Ipsilateral neck radiotherapy in N2b well-lateralized tonsil cancer - Approach with caution. 61
31059180 2019
24
Comment on "Ipsilateral neck radiotherapy in N2b well-lateralized tonsil cancer-Approach with caution". 61
31250944 2019
25
Tonsil Cancer. 61
31340096 2019
26
A case of palatine tonsillar metastasis of lung adenocarcinoma: A CARE-compliant article. 61
31145296 2019
27
Diverging incidence trends for larynx and tonsil cancer in low socioeconomic regions of the US. 61
30926064 2019
28
Optimizing laryngeal sparing with intensity modulated radiotherapy or volumetric modulated arc therapy for unilateral tonsil cancer. 61
33458265 2019
29
A novel human in vitro papillomavirus type 16 positive tonsil cancer cell line with high sensitivity to radiation and cisplatin. 61
30909875 2019
30
A Survival Analysis of Pediatric Tonsillar Malignancies and Review of a Rare Case. 61
30639969 2019
31
[Association of the expression of p53 and p16INK4A with the clinical and morphological characteristicsof patients with head and neck squamous cell cancer]. 61
31317926 2019
32
Base of tongue cancer-is it tongue cancer located at the base of the tongue, or is it a type of lingual tonsil cancer? The perspective from a genomic analysis. 61
29452725 2018
33
Modeling clustered long-term survivors using marginal mixture cure model. 61
29733452 2018
34
Differentiating Tonsil Cancer from Benign Tonsillar Hypertrophy. 61
29605393 2018
35
Pediatric Tonsil Cancer: A National and Institutional Perspective. 61
29571929 2018
36
Profiling dendritic cell subsets in head and neck squamous cell tonsillar cancer and benign tonsils. 61
29795118 2018
37
A 9-year analysis of transoral laser microsurgery (TLM) of head and neck cancer on their potential suitability for transoral robotic surgery (TORS) for estimation of future TORS-specific caseload. 61
29863236 2018
38
Staging Neck Dissection and Transoral Robotic Surgery Treatment Algorithm in Palatine Tonsil Cancer. 61
29160154 2018
39
Prevalence of synchronous bilateral tonsil squamous cell carcinoma: A retrospective study. 61
28891195 2018
40
Trend of oral and pharyngeal cancer mortality in Brazil in the period of 2002 to 2013. 61
29412371 2018
41
Computed tomographic appearance of canine tonsillar neoplasia: 14 cases. 61
28929544 2018
42
A Taiwanese population-based study on the association between chronic tonsillitis and tonsil cancer. 61
29484140 2018
43
Long term outcome after resection of liver metastases from squamous cell carcinoma. 61
28958732 2017
44
Triple-modality treatment in patients with advanced stage tonsil cancer. 61
28440876 2017
45
Chemoradiotherapy versus surgery followed by postoperative radiotherapy in tonsil cancer: Korean Radiation Oncology Group (KROG) study. 61
28854890 2017
46
Multimodality Treatment of Early-Stage Tonsil Cancer. 61
28669307 2017
47
Impact of fraction size on locally advanced oropharyngeal and nasopharyngeal cancers treated with chemoradiation. 61
28438289 2017
48
Is there an increased risk of cancer among spouses of patients with an HPV-related cancer: A systematic review. 61
28351568 2017
49
Synchronous bilateral tonsil carcinoma: case presentation and review of the literature. 61
28670333 2017
50
The Impact of Radiation Treatment Time on Survival in Patients With Head and Neck Cancer. 61
27869097 2016

Variations for Tonsil Cancer

Expression for Tonsil Cancer

Search GEO for disease gene expression data for Tonsil Cancer.

Pathways for Tonsil Cancer

GO Terms for Tonsil Cancer

Cellular components related to Tonsil Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.5 TP53 SERPINA3 PLAG1 NFIB MYBL1 MTA1

Biological processes related to Tonsil Cancer according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.88 TP53 TNF NFIB MYBL1 MTA1 CDKN2A
2 heart development GO:0007507 9.83 TP53 NTRK3 ERBB2 CDKN1B
3 regulation of cell proliferation GO:0042127 9.76 TP53 TNF KIT CDKN1B
4 positive regulation of kinase activity GO:0033674 9.67 NTRK3 KIT ERBB2
5 positive regulation of protein kinase B signaling GO:0051897 9.67 TNF MIR199A1 KIT ERBB2
6 positive regulation of MAP kinase activity GO:0043406 9.61 TNF KIT ERBB2
7 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.54 TP53 TNF
8 response to salt stress GO:0009651 9.51 TP53 TNF
9 positive regulation of gene expression GO:0010628 9.5 TP53 TNF PLAG1 NTRK3 KIT ERBB2
10 somatic stem cell division GO:0048103 9.48 KIT CDKN2A
11 negative regulation of mitotic cell cycle GO:0045930 9.43 TP53 TNF CDKN1B
12 entrainment of circadian clock by photoperiod GO:0043153 9.33 TP53 MTA1 CRTC1
13 negative regulation of immature T cell proliferation in thymus GO:0033088 9.32 ERBB2 CDKN2A
14 positive regulation of transcription by RNA polymerase II GO:0045944 9.28 TP53 TNF PLAG1 NFIB MYBL1 MAML2

Molecular functions related to Tonsil Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.65 TP53 PLAG1 NFIB MYBL1 ETV6
2 DNA binding GO:0003677 9.61 TP53 SERPINA3 PLAG1 NFIB MYBL1 MTA1
3 p53 binding GO:0002039 9.33 TP53 NTRK3 CDKN2A
4 MDM2/MDM4 family protein binding GO:0097371 9.32 TP53 CDKN2A
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 NTRK3 KIT ERBB2

Sources for Tonsil Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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