MCID: TNS013
MIFTS: 32

Tonsil Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Tonsil Squamous Cell Carcinoma

MalaCards integrated aliases for Tonsil Squamous Cell Carcinoma:

Name: Tonsil Squamous Cell Carcinoma 12 15
Tonsillar Squamous Cell Carcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050920
UMLS 71 C0280317

Summaries for Tonsil Squamous Cell Carcinoma

Disease Ontology : 12 A tonsil cancer that has material basis in squamous cells.

MalaCards based summary : Tonsil Squamous Cell Carcinoma, also known as tonsillar squamous cell carcinoma, is related to tonsil cancer and oropharynx cancer. An important gene associated with Tonsil Squamous Cell Carcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are ERK Signaling and Gene Expression. Affiliated tissues include tonsil, lymph node and tongue.

Related Diseases for Tonsil Squamous Cell Carcinoma

Diseases related to Tonsil Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 tonsil cancer 30.3 MIR193B CDKN2A
2 oropharynx cancer 30.1 MIR193B CDKN2A CCND1
3 squamous cell carcinoma 10.6
4 bowenoid papulosis 10.3 CDKN2A CCND1
5 esophagus verrucous carcinoma 10.3 CDKN2A CCND1
6 verrucous carcinoma 10.3 CDKN2A CCND1
7 bone squamous cell carcinoma 10.3 CDKN2A CCND1
8 chondromyxoid fibroma 10.3 CDKN2A CCND1
9 laryngeal benign neoplasm 10.3 CDKN2A CCND1
10 nodular malignant melanoma 10.2 CDKN2A CCND1
11 rhabdoid cancer 10.2 CDKN2A CCND1
12 respiratory system benign neoplasm 10.2 CDKN2A CCND1
13 inverted papilloma 10.2 CDKN2A CCND1
14 esophagus adenocarcinoma 10.1 CDKN2A CCND1
15 vulva cancer 10.1 CDKN2A CCND1
16 peripheral nervous system neoplasm 10.0 MIR193B CDKN2A CCND1
17 barrett esophagus 10.0 MIR193B CDKN2A CCND1
18 suppressor of tumorigenicity 3 10.0
19 mucositis 10.0
20 sensory peripheral neuropathy 10.0
21 neuropathy 10.0
22 desmoid tumor 10.0 CDKN2A CCND1
23 pilocytic astrocytoma of cerebellum 10.0 H3C11 H3C10
24 melanoma, uveal 10.0 MIR193B CDKN2A CCND1
25 reproductive organ benign neoplasm 9.8 CDKN2A CCND1
26 cerebellar astrocytoma 9.5 H3C12 H3C11 H3C10
27 glioma 9.3 H3C11 H3C1 CDKN2A CCND1
28 adult infiltrating astrocytic neoplasm 8.6 H3C7 H3C12 H3C11 H3C10 H3C1
29 childhood brain stem glioma 8.5 H3C7 H3C12 H3C11 H3C10 H3C1
30 brain stem cancer 8.5 H3C7 H3C12 H3C11 H3C10 H3C1
31 pilomyxoid astrocytoma 8.5 H3C7 H3C12 H3C11 H3C10 H3C1
32 brain stem glioma 8.4 H3C7 H3C12 H3C11 H3C10 H3C1 CDKN2A
33 infratentorial cancer 8.3 H3C7 H3C12 H3C11 H3C10 H3C1 CCND1
34 glioblastoma multiforme 8.1 H3C7 H3C12 H3C11 H3C10 H3C1 CDKN2A

Graphical network of the top 20 diseases related to Tonsil Squamous Cell Carcinoma:



Diseases related to Tonsil Squamous Cell Carcinoma

Symptoms & Phenotypes for Tonsil Squamous Cell Carcinoma

Drugs & Therapeutics for Tonsil Squamous Cell Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bayesian Phase II Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer Recruiting NCT03224000 Phase 2

Search NIH Clinical Center for Tonsil Squamous Cell Carcinoma

Genetic Tests for Tonsil Squamous Cell Carcinoma

Anatomical Context for Tonsil Squamous Cell Carcinoma

MalaCards organs/tissues related to Tonsil Squamous Cell Carcinoma:

40
Tonsil, Lymph Node, Tongue, Brain, Liver, Thyroid, Pituitary

Publications for Tonsil Squamous Cell Carcinoma

Articles related to Tonsil Squamous Cell Carcinoma:

(show top 50) (show all 163)
# Title Authors PMID Year
1
Comparative cost of transoral robotic surgery and radiotherapy (IMRT) in early stage tonsil cancer. 61
32057489 2020
2
Left atrial tumor thrombus with emboli to the brain and distal extremities: A case report. 61
32178936 2020
3
Canine tonsillar neoplasia and tonsillar metastasis from various primary neoplasms. 61
32352191 2020
4
Isolated pituitary fossa metastasis from a primary tonsillar squamous cell carcinoma: case report. 61
32234087 2020
5
A global epidemic increase of an HPV-induced tonsil and tongue base cancer - potential benefit from a pan-gender use of HPV vaccine. 61
31733108 2020
6
The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis. 61
32076488 2020
7
Risk of post-operative, pre-radiotherapy contralateral neck recurrence in patients treated with surgery followed by adjuvant radiotherapy for human papilloma virus-associated tonsil cancer. 61
31600090 2019
8
Solitary cystic metastatic lymph node of occult human papillomavirus-related oropharyngeal cancer mimicking second branchial cleft cyst: A case report. 61
31689859 2019
9
CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear Translocation. 61
31627350 2019
10
Ipsilateral neck radiotherapy in N2b well-lateralized tonsil cancer - Approach with caution. 61
31059180 2019
11
Hypoglycemia associated with disseminated metastatic tonsillar squamous cell carcinoma producing insulin-like growth factor-I in a Pomeranian dog. 61
31280499 2019
12
Longus Capitis Reconstruction of the Soft Palate. 61
31084255 2019
13
[One case of metastatic lymph node presented sarcomatoid differentiation of tonsillar squamous cell carcinoma]. 61
31550766 2019
14
Electrochemotherapy in treatment of canine oral non-tonsillar squamous cell carcinoma. A case series report. 61
31419028 2019
15
Racial disparities in tumor features and outcomes of patients with squamous cell carcinoma of the tonsil. 61
30152118 2019
16
Survival outcome of tonsillar squamous cell carcinoma (TSCC) in the context of human papillomavirus (HPV): A systematic review and meta-analysis. 61
29843958 2019
17
Pigmented Villonodular Synovitis Masquerading as a Metastasis: Imaging Features and Coaxial Needle Biopsy Technique. 61
32577111 2019
18
Concurrent Squamous Cell Carcinoma and Chronic Lymphocytic Leukemia Presenting as an Enlarging Neck Mass. 61
31010317 2019
19
Atypical Metastasis of p16-Positive Tonsillar Squamous Cell Carcinoma to the Pleura: A Case Report. 61
30098955 2018
20
Combination of panendoscopy and positron emission tomography/computed tomography increases detection of unknown primary head and neck carcinoma. 61
30194842 2018
21
Occult tonsillar squamous cell carcinoma in 2 dogs presenting for treatment of primary oral squamous cell carcinoma. 61
30510311 2018
22
Clinical implication of programmed cell death-1 ligand-1 expression in tonsillar squamous cell carcinoma in association with intratumoral heterogeneity, human papillomavirus, and epithelial-to-mesenchymal transition. 61
29634978 2018
23
Distribution of Metastatic Nodes in N0-1 Patients with Tonsillar Squamous Cell Carcinoma and Its Implications for Selective Neck Dissection. 61
30319869 2018
24
Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis. 61
29553868 2018
25
Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma. 61
29573210 2018
26
Monocle tumor as tonsillar squamous cell carcinoma metastasis: resolution after chemotherapy treatment. 61
29369338 2018
27
Staging Neck Dissection and Transoral Robotic Surgery Treatment Algorithm in Palatine Tonsil Cancer. 61
29160154 2018
28
The incidence of malignancy in clinically benign cystic lesions of the lateral neck: our experience and proposed diagnostic algorithm. 61
29282522 2018
29
Prevalence of synchronous bilateral tonsil squamous cell carcinoma: A retrospective study. 61
28891195 2018
30
Metastasis to the thyroid gland from a tonsil squamous cell carcinoma. 61
30264003 2018
31
Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma. 61
29338018 2018
32
Fanconi anaemia presenting as tonsillar squamous cell carcinoma. 61
29749370 2018
33
Risk of contralateral nodal failure following ipsilateral IMRT for node-positive tonsillar cancer. 61
29224820 2017
34
Synchronous, bilateral tonsillar carcinomas: Patient characteristics and human papillomavirus genotypes. 61
29103737 2017
35
Metastatic tonsillar squamous cell carcinoma masquerading as a pancreatic cystic tumor and diagnosed by EUS-guided FNA. 61
28631390 2017
36
Endobronchial Metastasis from Extrapulmonary Neoplasms: Analysis of Clinicopathologic Features and Cytological Evaluation by Bronchial Brushing. 61
28555346 2017
37
Comparison of the Clinical Outcomes of Patients with Squamous Cell Carcinoma of the Tonsil Receiving Postoperative Ipsilateral Versus Bilateral Neck Radiotherapy: A Propensity Score Matching Analysis (KROG 11-07). 61
28183163 2017
38
Multimodality Treatment of Early-Stage Tonsil Cancer. 61
28669307 2017
39
Systemic matrix metalloproteinase-8 response in chronic tonsillitis. 61
27804311 2017
40
Human polyomavirus and human papillomavirus prevalence and viral load in non-malignant tonsillar tissue and tonsillar carcinoma. 61
27832373 2017
41
Adjuvant radiation in the TORS era: Is there a benefit to omitting the tumor bed? 61
28274400 2017
42
Cutaneous Metastasis From Tonsillar Squamous Cell Carcinoma: Report and Review of the Literature. 61
28465869 2017
43
Continuing rise in oropharyngeal cancer in a high HPV prevalence area: A Danish population-based study from 2011 to 2014. 61
27888679 2017
44
No evidence for the presence of Epstein-Barr virus in squamous cell carcinoma of the mobile tongue. 61
28926591 2017
45
HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma. 61
28607924 2017
46
Double positivity for HPV DNA/p16 in tonsillar and base of tongue cancer improves prognostication: Insights from a large population-based study. 61
27537425 2016
47
Minimal benefit of tonsillectomy in T1-T2 tonsillar squamous cell carcinoma treated with chemoradiotherapy. 61
27449724 2016
48
Radiotherapy alone or combined with chemotherapy as definitive treatment for squamous cell carcinoma of the tonsil. 61
27059836 2016
49
Tonsillar Squamous Cell Carcinoma: An Additional Consideration for Atypical Glossodynia. 61
28437054 2016
50
Evaluation of the factors contributing to long-term survival in canine tonsillar squamous cell carcinoma. 61
27237121 2016

Variations for Tonsil Squamous Cell Carcinoma

Cosmic variations for Tonsil Squamous Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM112550399 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.197C>G p.S66* 12:45852496-45852496 0

Expression for Tonsil Squamous Cell Carcinoma

Search GEO for disease gene expression data for Tonsil Squamous Cell Carcinoma.

Pathways for Tonsil Squamous Cell Carcinoma

Pathways related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 H3C7 H3C12 H3C11 H3C10 H3C1 CDKN2A
2
Show member pathways
13.59 H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
3
Show member pathways
13.57 H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
4
Show member pathways
13.56 H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
5
Show member pathways
13.35 H3C7 H3C12 H3C11 H3C10 H3C1 H1-5
6
Show member pathways
13.28 H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
7
Show member pathways
13.14 H3C7 H3C12 H3C11 H3C10 H3C1 CCND1
8
Show member pathways
13.13 SYCP2 H3C7 H3C12 H3C11 H3C10 H3C1
9
Show member pathways
13.11 H3C7 H3C12 H3C11 H3C10 H3C1
10
Show member pathways
12.87 H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
11
Show member pathways
12.85 H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
12
Show member pathways
12.83 H3C7 H3C12 H3C11 H3C10 H3C1
13
Show member pathways
12.76 H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
14
Show member pathways
12.58 H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
15
Show member pathways
12.56 H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
16 12.29 H3C7 H3C12 H3C11 H3C10 H3C1
17 12.18 H3C7 H3C12 H3C11 H3C10 H3C1
18
Show member pathways
12.16 H2BC14 H1-5 H1-1
19
Show member pathways
12.16 SYCP2 H3C7 H3C12 H3C11 H3C10 H3C1
20 12.11 H2BC14 CDKN2A CCND1
21 12.03 H3C7 H3C12 H3C11 H3C10 H3C1
22
Show member pathways
11.92 H3C7 H3C12 H3C11 H3C10 H3C1
23
Show member pathways
11.91 H3C7 H3C12 H3C11 H3C10 H3C1
24 11.61 H3C7 H3C12 H3C11 H3C10 H3C1
25 11.15 H1-5 H1-1
26
Show member pathways
11.03 H1-5 H1-1
27 10.78 H1-5 H1-1
28 10.47 H3C7 H3C12 H3C11 H3C10 H3C1

GO Terms for Tonsil Squamous Cell Carcinoma

Cellular components related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.06 SYCP2 H3C7 H3C12 H3C11 H3C10 H3C1
2 nucleoplasm GO:0005654 10.03 H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
3 extracellular exosome GO:0070062 9.95 MIR193B H3C7 H3C12 H3C11 H3C10 H3C1
4 protein-containing complex GO:0032991 9.77 H3C7 H3C12 H3C11 H3C10 H3C1
5 nuclear chromosome GO:0000228 9.65 H3C7 H3C12 H3C11 H3C10 H3C1
6 host cell nucleus GO:0042025 9.63 H1-5 H1-1 CCND1
7 chromosome GO:0005694 9.61 SYCP2 H3C7 H3C12 H3C11 H3C10 H3C1
8 nuclear nucleosome GO:0000788 9.55 H3C7 H3C12 H3C11 H3C10 H3C1
9 nuclear euchromatin GO:0005719 9.48 H1-5 H1-1
10 nucleosome GO:0000786 9.23 H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14

Biological processes related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 chromatin organization GO:0006325 9.95 H3C7 H3C12 H3C11 H3C10 H3C1 H1-5
2 cellular protein metabolic process GO:0044267 9.91 H3C7 H3C12 H3C11 H3C10 H3C1
3 blood coagulation GO:0007596 9.89 H3C7 H3C12 H3C11 H3C10 H3C1
4 regulation of gene silencing by miRNA GO:0060964 9.85 H3C7 H3C12 H3C11 H3C10 H3C1
5 regulation of megakaryocyte differentiation GO:0045652 9.83 H3C7 H3C12 H3C11 H3C10 H3C1
6 negative regulation of gene expression, epigenetic GO:0045814 9.8 H3C7 H3C12 H3C11 H3C10 H3C1
7 chromatin silencing at rDNA GO:0000183 9.77 H3C7 H3C12 H3C11 H3C10 H3C1
8 DNA replication-dependent nucleosome assembly GO:0006335 9.72 H3C7 H3C12 H3C11 H3C10 H3C1
9 interleukin-7-mediated signaling pathway GO:0038111 9.65 H3C7 H3C12 H3C11 H3C10 H3C1
10 chromosome condensation GO:0030261 9.56 H1-5 H1-1
11 negative regulation of DNA recombination GO:0045910 9.55 H1-5 H1-1
12 telomere organization GO:0032200 9.55 H3C7 H3C12 H3C11 H3C10 H3C1
13 nucleosome positioning GO:0016584 9.54 H1-5 H1-1
14 negative regulation of chromatin silencing GO:0031936 9.52 H1-5 H1-1
15 regulation of gene silencing GO:0060968 9.35 H3C7 H3C12 H3C11 H3C10 H3C1
16 nucleosome assembly GO:0006334 9.23 H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14

Molecular functions related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cadherin binding GO:0045296 9.55 H3C7 H3C12 H3C11 H3C10 H3C1
2 protein heterodimerization activity GO:0046982 9.43 H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
3 DNA binding GO:0003677 9.32 SYCP2 H3C7 H3C12 H3C11 H3C10 H3C1
4 nucleosomal DNA binding GO:0031492 9.26 H1-5 H1-1

Sources for Tonsil Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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