MCID: TNS013
MIFTS: 30

Tonsil Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Tonsil Squamous Cell Carcinoma

MalaCards integrated aliases for Tonsil Squamous Cell Carcinoma:

Name: Tonsil Squamous Cell Carcinoma 12 15
Tonsillar Squamous Cell Carcinoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0050920
UMLS 70 C0280317

Summaries for Tonsil Squamous Cell Carcinoma

Disease Ontology : 12 A tonsil cancer that has material basis in squamous cells.

MalaCards based summary : Tonsil Squamous Cell Carcinoma, also known as tonsillar squamous cell carcinoma, is related to tonsil cancer and oropharynx cancer. An important gene associated with Tonsil Squamous Cell Carcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are ERK Signaling and Activation of cAMP-Dependent PKA. Affiliated tissues include tonsil, brain and lymph node.

Related Diseases for Tonsil Squamous Cell Carcinoma

Diseases related to Tonsil Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 tonsil cancer 30.4 MIR193B CDKN2A
2 oropharynx cancer 30.2 MIR193B CDKN2A CCND1
3 squamous cell carcinoma 10.5
4 bowenoid papulosis 10.2 CDKN2A CCND1
5 esophagus verrucous carcinoma 10.2 CDKN2A CCND1
6 verrucous carcinoma 10.2 CDKN2A CCND1
7 breast papillomatosis 10.2 CDKN2A CCND1
8 soft palate cancer 10.2 CDKN2A CCND1
9 ischemic fasciitis 10.2 CDKN2A CCND1
10 bone squamous cell carcinoma 10.2 CDKN2A CCND1
11 chondromyxoid fibroma 10.2 CDKN2A CCND1
12 laryngeal benign neoplasm 10.2 CDKN2A CCND1
13 nodular malignant melanoma 10.2 CDKN2A CCND1
14 respiratory system benign neoplasm 10.1 CDKN2A CCND1
15 esophagus adenocarcinoma 10.1 CDKN2A CCND1
16 fetishism 10.1 H1-5 H1-1
17 suppressor of tumorigenicity 3 10.1
18 mucositis 10.1
19 sensory peripheral neuropathy 10.1
20 neuropathy 10.1
21 reproductive organ benign neoplasm 10.0 CDKN2A CCND1
22 transvestism 10.0 H1-5 H1-1
23 peripheral nervous system neoplasm 10.0 MIR193B CDKN2A CCND1
24 desmoid tumor 10.0 CDKN2A CCND1
25 retinitis pigmentosa 18 10.0 H1-5 H1-1
26 melanoma, uveal 10.0 MIR193B CDKN2A CCND1
27 pilocytic astrocytoma of cerebellum 9.9 H3C11 H3C10
28 cerebellar astrocytoma 9.9 H3C11 H3C10
29 plasma cell leukemia 9.9 CDKN2A CCND1
30 glioma 9.6 H3C11 H3C1 CDKN2A CCND1
31 brain stem glioma 9.5 H3C12 H3C11 H3C10
32 adult infiltrating astrocytic neoplasm 9.2 H3C12 H3C11 H3C10 H3C1
33 childhood brain stem glioma 9.2 H3C12 H3C11 H3C10 H3C1
34 brain stem cancer 9.2 H3C12 H3C11 H3C10 H3C1
35 diffuse midline glioma, h3 k27m-mutant 9.2 H3C12 H3C11 H3C10 H3C1
36 pilomyxoid astrocytoma 9.2 H3C12 H3C11 H3C10 H3C1

Graphical network of the top 20 diseases related to Tonsil Squamous Cell Carcinoma:



Diseases related to Tonsil Squamous Cell Carcinoma

Symptoms & Phenotypes for Tonsil Squamous Cell Carcinoma

Drugs & Therapeutics for Tonsil Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Tonsil Squamous Cell Carcinoma

Genetic Tests for Tonsil Squamous Cell Carcinoma

Anatomical Context for Tonsil Squamous Cell Carcinoma

MalaCards organs/tissues related to Tonsil Squamous Cell Carcinoma:

40
Tonsil, Brain, Lymph Node, Tongue, Pituitary, Bone, Cerebellum

Publications for Tonsil Squamous Cell Carcinoma

Articles related to Tonsil Squamous Cell Carcinoma:

(show top 50) (show all 175)
# Title Authors PMID Year
1
The emergence of oral cavity cancer and the stabilization of oropharyngeal cancer: Recent contrasting epidemics in the South Korean population. 61
33595858 2021
2
Heterogeneous Response to Immunotherapy in a Patient with Tonsillar Squamous Cell Carcinoma Assessed by 18F-FDG PET/CT. 61
33669822 2021
3
Technical feasibility of radiomics signature analyses for improving detection of occult tonsillar cancer. 61
33420249 2021
4
Is the retropharyngeal lymph node the first echelon node for carcinoma tonsil? Prospective evaluation and literature review. 61
33417147 2021
5
Long-term survival in a cat with tonsillar squamous cell carcinoma treated with surgery and chemotherapy. 61
33614106 2021
6
Transoral robotic submandibular gland transposition to reconstruct radical tonsillar resection defects. 61
33506547 2021
7
Clostridium difficile appendicitis in an immunocompromised patient: a case report and review of the literature. 61
33402156 2021
8
MRI-Based Assessment of the Pharyngeal Constrictor Muscle as a Predictor of Surgical Margin after Transoral Robotic Surgery in HPV-Positive Tonsillar Cancer. 61
33060104 2020
9
Treatment of Early Stage Tonsil Cancer in the Age of Human Papillomavirus-Associated Malignancies. 61
33290171 2020
10
Canine tonsillar neoplasia and tonsillar metastasis from various primary neoplasms. 61
32352191 2020
11
Establishing cell lines for canine tonsillar and non-tonsillar oral squamous cell carcinoma and identifying characteristics associated with malignancy. 61
32835941 2020
12
Electrochemotherapy in treatment of canine oral non-tonsillar squamous cell carcinoma. A case series report. 61
31419028 2020
13
Comparative cost of transoral robotic surgery and radiotherapy (IMRT) in early stage tonsil cancer. 61
32057489 2020
14
Left atrial tumor thrombus with emboli to the brain and distal extremities: A case report. 61
32178936 2020
15
Isolated pituitary fossa metastasis from a primary tonsillar squamous cell carcinoma: case report. 61
32234087 2020
16
A global epidemic increase of an HPV-induced tonsil and tongue base cancer - potential benefit from a pan-gender use of HPV vaccine. 61
31733108 2020
17
Establishment and Validation of a Nomogram for Tonsil Squamous Cell Carcinoma: A Retrospective Study Based on the SEER Database. 61
32951460 2020
18
The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis. 61
32076488 2020
19
Risk of post-operative, pre-radiotherapy contralateral neck recurrence in patients treated with surgery followed by adjuvant radiotherapy for human papilloma virus-associated tonsil cancer. 61
31600090 2019
20
Solitary cystic metastatic lymph node of occult human papillomavirus-related oropharyngeal cancer mimicking second branchial cleft cyst: A case report. 61
31689859 2019
21
CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear Translocation. 61
31627350 2019
22
[One case of metastatic lymph node presented sarcomatoid differentiation of tonsillar squamous cell carcinoma]. 61
31550766 2019
23
Longus Capitis Reconstruction of the Soft Palate. 61
31084255 2019
24
Ipsilateral neck radiotherapy in N2b well-lateralized tonsil cancer - Approach with caution. 61
31059180 2019
25
Hypoglycemia associated with disseminated metastatic tonsillar squamous cell carcinoma producing insulin-like growth factor-I in a Pomeranian dog. 61
31280499 2019
26
Racial disparities in tumor features and outcomes of patients with squamous cell carcinoma of the tonsil. 61
30152118 2019
27
Survival outcome of tonsillar squamous cell carcinoma (TSCC) in the context of human papillomavirus (HPV): A systematic review and meta-analysis. 61
29843958 2019
28
Pigmented Villonodular Synovitis Masquerading as a Metastasis: Imaging Features and Coaxial Needle Biopsy Technique. 61
32577111 2019
29
Concurrent Squamous Cell Carcinoma and Chronic Lymphocytic Leukemia Presenting as an Enlarging Neck Mass. 61
31010317 2019
30
Incidentally Detected 18F-FDG-Avid Prostate Cancer Diagnosed Using a Novel Fusion Biopsy Platform. 61
32760804 2019
31
Atypical Metastasis of p16-Positive Tonsillar Squamous Cell Carcinoma to the Pleura: A Case Report. 61
30098955 2018
32
Combination of panendoscopy and positron emission tomography/computed tomography increases detection of unknown primary head and neck carcinoma. 61
30194842 2018
33
Occult tonsillar squamous cell carcinoma in 2 dogs presenting for treatment of primary oral squamous cell carcinoma. 61
30510311 2018
34
Clinical implication of programmed cell death-1 ligand-1 expression in tonsillar squamous cell carcinoma in association with intratumoral heterogeneity, human papillomavirus, and epithelial-to-mesenchymal transition. 61
29634978 2018
35
Distribution of Metastatic Nodes in N0-1 Patients with Tonsillar Squamous Cell Carcinoma and Its Implications for Selective Neck Dissection. 61
30319869 2018
36
Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis. 61
29553868 2018
37
Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma. 61
29573210 2018
38
Monocle tumor as tonsillar squamous cell carcinoma metastasis: resolution after chemotherapy treatment. 61
29369338 2018
39
Staging Neck Dissection and Transoral Robotic Surgery Treatment Algorithm in Palatine Tonsil Cancer. 61
29160154 2018
40
The incidence of malignancy in clinically benign cystic lesions of the lateral neck: our experience and proposed diagnostic algorithm. 61
29282522 2018
41
Prevalence of synchronous bilateral tonsil squamous cell carcinoma: A retrospective study. 61
28891195 2018
42
Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma. 61
29338018 2018
43
Metastasis to the thyroid gland from a tonsil squamous cell carcinoma. 61
30264003 2018
44
Fanconi anaemia presenting as tonsillar squamous cell carcinoma. 61
29749370 2018
45
Risk of contralateral nodal failure following ipsilateral IMRT for node-positive tonsillar cancer. 61
29224820 2017
46
Synchronous, bilateral tonsillar carcinomas: Patient characteristics and human papillomavirus genotypes. 61
29103737 2017
47
Metastatic tonsillar squamous cell carcinoma masquerading as a pancreatic cystic tumor and diagnosed by EUS-guided FNA. 61
28631390 2017
48
Comparison of the Clinical Outcomes of Patients with Squamous Cell Carcinoma of the Tonsil Receiving Postoperative Ipsilateral Versus Bilateral Neck Radiotherapy: A Propensity Score Matching Analysis (KROG 11-07). 61
28183163 2017
49
Endobronchial Metastasis from Extrapulmonary Neoplasms: Analysis of Clinicopathologic Features and Cytological Evaluation by Bronchial Brushing. 61
28555346 2017
50
Multimodality Treatment of Early-Stage Tonsil Cancer. 61
28669307 2017

Variations for Tonsil Squamous Cell Carcinoma

Expression for Tonsil Squamous Cell Carcinoma

Search GEO for disease gene expression data for Tonsil Squamous Cell Carcinoma.

Pathways for Tonsil Squamous Cell Carcinoma

Pathways related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.55 H3C12 H3C11 H3C10 H3C1 CDKN2A CCND1
2
Show member pathways
13.29 H3C12 H3C11 H3C10 H3C1 H1-5 H1-1
3
Show member pathways
13.11 H3C12 H3C11 H3C10 H3C1 CCND1
4
Show member pathways
13.02 SYCP2 H3C12 H3C11 H3C10 H3C1 H2BC14
5
Show member pathways
12.79 H3C12 H3C11 H3C10 H3C1 H2BC14
6
Show member pathways
12.69 H3C12 H3C11 H3C10 H3C1 H2BC14 CCND1
7
Show member pathways
12.67 H3C12 H3C11 H3C10 H3C1 H2BC14
8
Show member pathways
12.5 H3C12 H3C11 H3C10 H3C1 H2BC14
9 12.22 H3C12 H3C11 H3C10 H3C1
10
Show member pathways
12.17 H3C12 H3C11 H3C10 H3C1 H2BC14 H1-5
11
Show member pathways
12.12 H2BC14 H1-5 H1-1
12
Show member pathways
12.1 SYCP2 H3C12 H3C11 H3C10 H3C1 H2BC14
13 12.08 H3C12 H3C11 H3C10 H3C1
14 12.06 H2BC14 CDKN2A CCND1
15 11.95 H3C12 H3C11 H3C10 H3C1
16
Show member pathways
11.86 H3C12 H3C11 H3C10 H3C1
17
Show member pathways
11.84 H3C12 H3C11 H3C10 H3C1
18 11.58 H3C12 H3C11 H3C10 H3C1
19 11.1 H1-5 H1-1
20
Show member pathways
10.98 H1-5 H1-1
21 10.75 H1-5 H1-1
22 10.7 H3C12 H3C11 H3C10 H3C1

GO Terms for Tonsil Squamous Cell Carcinoma

Cellular components related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.02 SYCP2 H3C12 H3C11 H3C10 H3C1 H2BC14
2 nucleoplasm GO:0005654 9.97 H3C12 H3C11 H3C10 H3C1 H2BC14 H1-1
3 extracellular exosome GO:0070062 9.91 MIR193B H3C12 H3C11 H3C10 H3C1 H2BC14
4 protein-containing complex GO:0032991 9.65 H3C12 H3C11 H3C10 H3C1 CDKN2A
5 host cell nucleus GO:0042025 9.58 H1-5 H1-1 CCND1
6 chromosome GO:0005694 9.56 SYCP2 H3C12 H3C11 H3C10 H3C1 H2BC14
7 euchromatin GO:0000791 9.46 H1-5 H1-1
8 nuclear chromosome GO:0000228 9.46 H3C12 H3C11 H3C10 H3C1
9 nucleosome GO:0000786 9.17 H3C12 H3C11 H3C10 H3C1 H2BC14 H1-5

Biological processes related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 chromatin organization GO:0006325 9.88 H3C12 H3C11 H3C10 H3C1 H1-5
2 cellular protein metabolic process GO:0044267 9.81 H3C12 H3C11 H3C10 H3C1
3 blood coagulation GO:0007596 9.8 H3C12 H3C11 H3C10 H3C1
4 regulation of gene silencing by miRNA GO:0060964 9.76 H3C12 H3C11 H3C10 H3C1
5 regulation of megakaryocyte differentiation GO:0045652 9.73 H3C12 H3C11 H3C10 H3C1
6 negative regulation of gene expression, epigenetic GO:0045814 9.71 H3C12 H3C11 H3C10 H3C1
7 chromatin silencing at rDNA GO:0000183 9.67 H3C12 H3C11 H3C10 H3C1
8 DNA replication-dependent nucleosome assembly GO:0006335 9.62 H3C12 H3C11 H3C10 H3C1
9 chromosome condensation GO:0030261 9.56 H1-5 H1-1
10 interleukin-7-mediated signaling pathway GO:0038111 9.56 H3C12 H3C11 H3C10 H3C1
11 negative regulation of DNA recombination GO:0045910 9.55 H1-5 H1-1
12 nucleosome positioning GO:0016584 9.54 H1-5 H1-1
13 negative regulation of chromatin silencing GO:0031936 9.52 H1-5 H1-1
14 telomere organization GO:0032200 9.46 H3C12 H3C11 H3C10 H3C1
15 regulation of gene silencing GO:0060968 9.26 H3C12 H3C11 H3C10 H3C1
16 nucleosome assembly GO:0006334 9.17 H3C12 H3C11 H3C10 H3C1 H2BC14 H1-5

Molecular functions related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cadherin binding GO:0045296 9.46 H3C12 H3C11 H3C10 H3C1
2 protein heterodimerization activity GO:0046982 9.35 H3C12 H3C11 H3C10 H3C1 H2BC14
3 DNA binding GO:0003677 9.28 SYCP2 H3C12 H3C11 H3C10 H3C1 H2BC14
4 nucleosomal DNA binding GO:0031492 9.26 H1-5 H1-1

Sources for Tonsil Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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