MCID: TNS013
MIFTS: 30

Tonsil Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Tonsil Squamous Cell Carcinoma

MalaCards integrated aliases for Tonsil Squamous Cell Carcinoma:

Name: Tonsil Squamous Cell Carcinoma 12 15
Tonsillar Squamous Cell Carcinoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050920
UMLS 74 C0280317

Summaries for Tonsil Squamous Cell Carcinoma

Disease Ontology : 12 A tonsil cancer that has material basis in squamous cells.

MalaCards based summary : Tonsil Squamous Cell Carcinoma, also known as tonsillar squamous cell carcinoma, is related to squamous cell carcinoma and breast papillomatosis. An important gene associated with Tonsil Squamous Cell Carcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are DNA Damage Response (only ATM dependent) and Glioblastoma Multiforme. The drugs nivolumab and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include tonsil, tongue and lymph node.

Related Diseases for Tonsil Squamous Cell Carcinoma

Diseases related to Tonsil Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 10.4
2 breast papillomatosis 10.1 CCND1 CDKN2A
3 papilloma 10.1 CCND1 CDKN2A
4 bowenoid papulosis 10.1 CCND1 CDKN2A
5 skin carcinoma in situ 10.1 CCND1 CDKN2A
6 endometrial squamous cell carcinoma 10.1 CCND1 CDKN2A
7 oral leukoplakia 10.1 CCND1 CDKN2A
8 ischemic fasciitis 10.1 CCND1 CDKN2A
9 verrucous carcinoma 10.1 CCND1 CDKN2A
10 pre-malignant neoplasm 10.1 CCND1 CDKN2A
11 chondromyxoid fibroma 10.1 CCND1 CDKN2A
12 laryngeal disease 10.1 CCND1 CDKN2A
13 oropharynx cancer 10.1 CCND1 CDKN2A
14 pharynx cancer 10.1 CCND1 CDKN2A
15 inverted papilloma 10.1 CCND1 CDKN2A
16 penile cancer 10.1 CCND1 CDKN2A
17 nasopharyngeal disease 10.1 CCND1 CDKN2A
18 retinal cancer 10.1 CCND1 CDKN2A
19 esophageal disease 10.1 CCND1 CDKN2A
20 cervix disease 10.1 CCND1 CDKN2A
21 ocular cancer 10.1 CCND1 CDKN2A
22 uterine anomalies 10.1 CCND1 CDKN2A
23 bladder disease 10.1 CCND1 CDKN2A
24 tongue cancer 10.1 CCND1 CDKN2A
25 laryngeal squamous cell carcinoma 10.1 CCND1 CDKN2A
26 oral cancer 10.1 CCND1 CDKN2A
27 female reproductive system disease 10.0 CCND1 CDKN2A
28 reproductive system disease 10.0 CCND1 CDKN2A
29 nervous system cancer 10.0 CCND1 CDKN2A
30 respiratory system cancer 10.0 CCND1 CDKN2A
31 gastrointestinal system cancer 10.0 CCND1 CDKN2A
32 endocrine gland cancer 10.0 CCND1 CDKN2A
33 larynx cancer 10.0 CCND1 CDKN2A
34 gastrointestinal system disease 10.0 CCND1 CDKN2A
35 pancreas adenocarcinoma 10.0 CCND1 CDKN2A
36 mantle cell lymphoma 9.9 CCND1 CDKN2A
37 lynch syndrome 9.9 CCND1 CDKN2A
38 barrett esophagus 9.8 CCND1 CDKN2A
39 squamous cell carcinoma, head and neck 9.8 CCND1 CDKN2A MMP13
40 gastrointestinal stromal tumor 9.7 CCND1 CDKN2A

Graphical network of the top 20 diseases related to Tonsil Squamous Cell Carcinoma:



Diseases related to Tonsil Squamous Cell Carcinoma

Symptoms & Phenotypes for Tonsil Squamous Cell Carcinoma

Drugs & Therapeutics for Tonsil Squamous Cell Carcinoma

Drugs for Tonsil Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Ipilimumab Approved Phase 2 477202-00-9
3 Antineoplastic Agents, Immunological Phase 2
4 Antibodies Phase 2
5 Immunoglobulins Phase 2
6 Antibodies, Monoclonal Phase 2
7
Ribavirin Approved Not Applicable 36791-04-5 37542
8 Antimetabolites Not Applicable
9 Antiviral Agents Not Applicable
10 Anti-Infective Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma Not yet recruiting NCT03799445 Phase 2
2 Pharmacodynamic Effects of Ribavirin in Patients With Tonsil and/or Base of Tongue Squamous Cell Carcinoma Active, not recruiting NCT01268579 Not Applicable ribavirin

Search NIH Clinical Center for Tonsil Squamous Cell Carcinoma

Genetic Tests for Tonsil Squamous Cell Carcinoma

Anatomical Context for Tonsil Squamous Cell Carcinoma

MalaCards organs/tissues related to Tonsil Squamous Cell Carcinoma:

42
Tonsil, Tongue, Lymph Node, Thyroid, T Cells, Skin, Pancreas

Publications for Tonsil Squamous Cell Carcinoma

Articles related to Tonsil Squamous Cell Carcinoma:

(show top 50) (show all 67)
# Title Authors Year
1
Survival outcome of tonsillar squamous cell carcinoma (TSCC) in the context of human papillomavirus (HPV): A systematic review and meta-analysis. ( 29843958 )
2019
2
Occult tonsillar squamous cell carcinoma in 2 dogs presenting for treatment of primary oral squamous cell carcinoma. ( 30510311 )
2018
3
Metastasis to the thyroid gland from a tonsil squamous cell carcinoma. ( 30264003 )
2018
4
Distribution of Metastatic Nodes in N0-1 Patients with Tonsillar Squamous Cell Carcinoma and Its Implications for Selective Neck Dissection. ( 30319869 )
2018
5
Atypical Metastasis of p16-Positive Tonsillar Squamous Cell Carcinoma to the Pleura: A Case Report. ( 30098955 )
2018
6
Fanconi anaemia presenting as tonsillar squamous cell carcinoma. ( 29749370 )
2018
7
Prevalence of synchronous bilateral tonsil squamous cell carcinoma: A retrospective study. ( 28891195 )
2018
8
Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma. ( 29338018 )
2018
9
Monocle tumor as tonsillar squamous cell carcinoma metastasis: resolution after chemotherapy treatment. ( 29369338 )
2018
10
Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis. ( 29553868 )
2018
11
Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma. ( 29573210 )
2018
12
Clinical implication of programmed cell death-1 ligand-1 expression in tonsillar squamous cell carcinoma in association with intratumoral heterogeneity, human papillomavirus, and epithelial-to-mesenchymal transition. ( 29634978 )
2018
13
Cutaneous Metastasis From Tonsillar Squamous Cell Carcinoma: Report and Review of the Literature. ( 28465869 )
2017
14
HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma. ( 28607924 )
2017
15
Metastatic tonsillar squamous cell carcinoma masquerading as a pancreatic cystic tumor and diagnosed by EUS-guided FNA. ( 28631390 )
2017
16
Tonsillar Squamous Cell Carcinoma: An Additional Consideration for Atypical Glossodynia. ( 28437054 )
2016
17
In this issue - June 2016: High-quality care improves outcome in recumbent dairy cattle · Corneal anaesthesia in clinically normal cattle · Severe hyponatraemia in foals · Ultrasonographically visible hepatic location in clinically normal horses · Long-term survival in canine tonsillar squamous cell carcinoma · Treatment of oral squamous cell carcinoma in an inshore bottlenose dolphin · Alphaherpesvirus-associated disease in greater bilbies. ( 27237116 )
2016
18
Synchronous bilateral tonsillar squamous cell carcinoma related to human papillomavirus: Two case reports and a brief review of the literature. ( 27140027 )
2016
19
Evaluation of the factors contributing to long-term survival in canine tonsillar squamous cell carcinoma. ( 27237121 )
2016
20
Minimal benefit of tonsillectomy in T1-T2 tonsillar squamous cell carcinoma treated with chemoradiotherapy. ( 27449724 )
2016
21
Dermatomyositis paraneoplastic syndrome before symptomatic tonsillar squamous cell carcinoma: a case report. ( 24715579 )
2015
22
Prevalence and prognostic value of human papillomavirus genotypes in tonsillar squamous cell carcinoma: a Korean multicenter study. ( 25283642 )
2015
23
Molecular Pathogenesis of Human Papillomavirus Type 16 in Tonsillar Squamous Cell Carcinoma. ( 26637879 )
2015
24
Patients with HPV-related tonsil squamous cell carcinoma rarely harbour oncogenic HPV infection at other pharyngeal sites. ( 24434066 )
2014
25
Frequent hepatocyte growth factor overexpression and low frequency of c-Met gene amplification in human papillomavirus-negative tonsillar squamous cell carcinoma and their prognostic significances. ( 24810547 )
2014
26
Human papillomavirus-related cell cycle markers can predict survival outcomes following a transoral lateral oropharyngectomy for tonsillar squamous cell carcinoma. ( 24898120 )
2014
27
Human papillomavirus, smoking status and outcomes in tonsillar squamous cell carcinoma. ( 23180456 )
2013
28
Oral non-tonsillar squamous cell carcinoma in young dogs. ( 23314436 )
2013
29
Can concurrent chemoradiotherapy replace surgery and postoperative radiation for locally advanced stage III/IV tonsillar squamous cell carcinoma? ( 23482808 )
2013
30
Treatment selection for tonsillar squamous cell carcinoma. ( 23557888 )
2013
31
TWIST1 promoter methylation is associated with prognosis in tonsillar squamous cell carcinoma. ( 23664538 )
2013
32
Histopathologic predictors of lymph node metastasis and prognosis in tonsillar squamous cell carcinoma. ( 23837012 )
2013
33
Importance of FOXP3 in prognosis and its relationship with p16 in tonsillar squamous cell carcinoma. ( 24324115 )
2013
34
MHC class I expression in HPV positive and negative tonsillar squamous cell carcinoma in correlation to clinical outcome. ( 22592660 )
2013
35
Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV16 integration and indicates a favorable prognosis. ( 22987500 )
2013
36
Expression of human papillomavirus-related proteins and its clinical implication in tonsillar squamous cell carcinoma. ( 23109998 )
2012
37
Small lymphocytic lymphoma obscuring microscopic tonsillar squamous cell carcinoma: an unknown occurrence with a known primary. ( 21120710 )
2012
38
Fatal course of tonsillar squamous cell carcinoma associated with Fanconi anaemia: a mini review. ( 21925890 )
2012
39
Histological subtypes of oral non-tonsillar squamous cell carcinoma in dogs. ( 22300705 )
2012
40
Altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma. ( 21480761 )
2011
41
Management of cervical lymph node metastasis in tonsillar squamous cell carcinoma: Is it necessary to treat node-negative contralateral neck? ( 21255949 )
2011
42
Rib metastases from a non-tonsillar squamous cell carcinoma in a dog. ( 21294732 )
2011
43
Tonsillar squamous cell carcinoma: are we making a difference? ( 21493288 )
2011
44
Canine tonsillar squamous cell carcinoma -- a multi-centre retrospective review of 44 clinical cases. ( 21726228 )
2011
45
Tissue microarray evidence of association between p16 and phosphorylated eIF4E in tonsillar squamous cell carcinoma. ( 21837706 )
2011
46
Tonsillar squamous cell carcinoma associated with dermatomyositis: the first 2 cases in Korea. ( 20499432 )
2010
47
Synchronous bilateral tonsil squamous cell carcinoma. ( 21225779 )
2010
48
Clinical nodal staging of T1-2 tonsillar squamous cell carcinoma stratified by p16 status and implications for ipsilateral neck irradiation. ( 20526108 )
2010
49
Lichen sclerosis et atrophicus masquerading as tonsillar squamous cell carcinoma. ( 19102814 )
2009
50
Transoral resection of tonsillar squamous cell carcinoma. ( 19235742 )
2009

Variations for Tonsil Squamous Cell Carcinoma

Cosmic variations for Tonsil Squamous Cell Carcinoma:

9 (show top 50) (show all 87)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM4600074 ZFHX3 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.10826C>T p.S3609F 16:72787450-72787450 0
2 COSM6962637 ZFHX3 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.3312C>G p.I1104M 16:72889867-72889867 0
3 COSM6963645 WT1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.88G>A p.G30S 11:32435054-32435054 0
4 COSM6972475 U2AF1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.103C>G p.R35G 21:43104344-43104344 0
5 COSM6972463 TP63 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1046G>T p.G349V 3:189868633-189868633 0
6 COSM6927964 TP63 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1192G>A p.D398N 3:189869386-189869386 0
7 COSM44076 TP53 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.655C>T p.P219S 17:7674876-7674876 0
8 COSM6972473 TOP1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.538G>C p.D180H 20:41084492-41084492 0
9 COSM6962629 TGFBR1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1323G>C p.M441I 9:99147721-99147721 0
10 COSM6982550 TENT5C upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.511G>C p.D171H 1:117623379-117623379 0
11 COSM6907202 SOX2 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.293G>A p.R98Q 3:181712653-181712653 0
12 COSM6962643 SMARCA4 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.935C>G p.S312C 19:10987741-10987741 0
13 COSM1014499 SF3B1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2104C>T p.R702W 2:197402104-197402104 0
14 COSM6962624 ROS1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.3763G>C p.D1255H 6:117357895-117357895 0
15 COSM6962644 PTPRT upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.4330G>A p.E1444K 20:42081890-42081890 0
16 COSM6982548 PIK3CD upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.73C>G p.L25V 1:9710528-9710528 0
17 COSM760 PIK3CA upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1624G>A p.E542K 3:179218294-179218294 0
18 COSM763 PIK3CA upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1633G>A p.E545K 3:179218303-179218303 0
19 COSM6961258 NFKBIA upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.153G>C p.E51D 14:35404492-35404492 0
20 COSM6961260 NFKBIA upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.95G>A p.S32N 14:35404550-35404550 0
21 COSM6975980 NFE2L2 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1507A>T p.R503W 2:177231096-177231096 0
22 COSM6982557 MET upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.3265A>G p.I1089V 7:116775063-116775063 0
23 COSM6962635 LATS2 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.316G>A p.E106K 13:21045711-21045711 0
24 COSM521 KRAS upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.35G>A p.G12D 12:25245350-25245350 0
25 COSM542 KRAS upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.53C>A p.A18D 12:25245332-25245332 0
26 COSM6962628 KMT2C upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.12022G>C p.E4008Q 7:152154384-152154384 0
27 COSM4125151 KIT upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1156G>A p.E386K 4:54709464-54709464 0
28 COSM94572 KEAP1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1085G>A p.R362Q 19:10491817-10491817 0
29 COSM6972470 KEAP1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.640-1G>A p.? 19:10492263-10492263 0
30 COSM6962632 KDM5A upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.3382G>A p.A1128T 12:308002-308002 0
31 COSM6961253 JAK1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2266A>T p.I756F 1:64844201-64844201 0
32 COSM6962640 INSR upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2542+1G>T p.? 19:7142815-7142815 0
33 COSM6962626 INHBA upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1094C>T p.S365L 7:41689837-41689837 0
34 COSM6962623 HIST1H3G upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.205C>A p.Q69K 6:26271180-26271180 0
35 COSM6972469 GPS2 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.509C>T p.A170V 17:7313693-7313693 0
36 COSM6960033 FOXA1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.288G>A p.M96I 14:37592496-37592496 0
37 COSM6972466 FLT1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.989-1G>C p.? 13:28430168-28430168 0
38 COSM27083 FBXW7 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2065C>T p.R689W 4:152322940-152322940 0
39 COSM3587776 EPHB1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.508C>T p.R170W 3:134951755-134951755 0
40 COSM6982554 EPHB1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1973C>T p.S658L 3:135192666-135192666 0
41 COSM5693798 EPHA7 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2251G>C p.D751H 6:93255959-93255959 0
42 COSM22952 EGFR upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2438A>G p.Y813C 7:55181447-55181447 0
43 COSM22954 EGFR upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2324G>A p.C775Y 7:55181333-55181333 0
44 COSM22953 EGFR upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2401T>C p.Y801H 7:55181410-55181410 0
45 COSM3936685 DICER1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.4072C>T p.R1358C 14:95099914-95099914 0
46 COSM6982551 CXCR4 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.213G>C p.K71N 2:136115727-136115727 0
47 COSM6961254 CSF1R upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1772G>A p.G591E 5:150061577-150061577 0
48 COSM6962636 CREBBP upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.4022G>C p.R1341P 16:3740510-3740510 0
49 COSM6962619 COP1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.402C>G p.F134L 1:176206577-176206577 0
50 COSM6972471 CIC upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.247G>A p.E83K 19:42287035-42287035 0

Expression for Tonsil Squamous Cell Carcinoma

Search GEO for disease gene expression data for Tonsil Squamous Cell Carcinoma.

Pathways for Tonsil Squamous Cell Carcinoma

Pathways related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.38 CCND1 CDKN2A
2 11.3 CCND1 CDKN2A
3 11.02 CCND1 CDKN2A
4 10.66 CCND1 CDKN2A
5 10.21 CCND1 MMP13

GO Terms for Tonsil Squamous Cell Carcinoma

Biological processes related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G1/S transition of mitotic cell cycle GO:0000082 8.62 CCND1 CDKN2A

Sources for Tonsil Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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