MCID: TNS013
MIFTS: 24

Tonsil Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Tonsil Squamous Cell Carcinoma

MalaCards integrated aliases for Tonsil Squamous Cell Carcinoma:

Name: Tonsil Squamous Cell Carcinoma 12 15
Tonsillar Squamous Cell Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050920
UMLS 73 C0280317

Summaries for Tonsil Squamous Cell Carcinoma

Disease Ontology : 12 A tonsil cancer that has material basis in squamous cells.

MalaCards based summary : Tonsil Squamous Cell Carcinoma, also known as tonsillar squamous cell carcinoma, is related to tonsillitis and squamous cell carcinoma. An important gene associated with Tonsil Squamous Cell Carcinoma is EDA2R (Ectodysplasin A2 Receptor), and among its related pathways/superpathways are Matrix Metalloproteinases and Angiogenesis (CST). The drugs Ribavirin and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include tonsil and tongue.

Related Diseases for Tonsil Squamous Cell Carcinoma

Diseases related to Tonsil Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 tonsillitis 10.2
2 squamous cell carcinoma 10.2
3 pharyngitis 9.9
4 tooth agenesis 9.7 EDA2R MMP13
5 sorsby fundus dystrophy 9.4 MMP13 TIMP2
6 inguinal hernia 9.4 MMP13 TIMP2
7 aortic aneurysm, familial abdominal, 1 9.3 MMP13 TIMP2
8 basal cell carcinoma 9.2 KRT16 MMP13
9 fundus dystrophy 9.1 MMP13 TIMP2

Graphical network of the top 20 diseases related to Tonsil Squamous Cell Carcinoma:



Diseases related to Tonsil Squamous Cell Carcinoma

Symptoms & Phenotypes for Tonsil Squamous Cell Carcinoma

Drugs & Therapeutics for Tonsil Squamous Cell Carcinoma

Drugs for Tonsil Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Not Applicable 36791-04-5 37542
2 Anti-Infective Agents Not Applicable
3 Antimetabolites Not Applicable
4 Antiviral Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pharmacodynamic Effects of Ribavirin in Patients With Tonsil and/or Base of Tongue Squamous Cell Carcinoma Active, not recruiting NCT01268579 Not Applicable ribavirin

Search NIH Clinical Center for Tonsil Squamous Cell Carcinoma

Genetic Tests for Tonsil Squamous Cell Carcinoma

Anatomical Context for Tonsil Squamous Cell Carcinoma

MalaCards organs/tissues related to Tonsil Squamous Cell Carcinoma:

41
Tonsil, Tongue

Publications for Tonsil Squamous Cell Carcinoma

Articles related to Tonsil Squamous Cell Carcinoma:

# Title Authors Year
1
Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma. ( 29338018 )
2018
2
Prevalence of synchronous bilateral tonsil squamous cell carcinoma: A retrospective study. ( 28891195 )
2017
3
Patients with HPV-related tonsil squamous cell carcinoma rarely harbour oncogenic HPV infection at other pharyngeal sites. ( 24434066 )
2014
4
Synchronous bilateral tonsil squamous cell carcinoma. ( 21225779 )
2010
5
Role of planned neck dissection for advanced metastatic disease in tongue base or tonsil squamous cell carcinoma treated with radiotherapy. ( 12001078 )
2002

Variations for Tonsil Squamous Cell Carcinoma

Cosmic variations for Tonsil Squamous Cell Carcinoma:

9
(show top 50) (show all 87)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM4600074 ZFHX3 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.10826C>T p.S3609F 16:72787450-72787450 9
2 COSM6962637 ZFHX3 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.3312C>G p.I1104M 16:72889867-72889867 9
3 COSM6963645 WT1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.88G>A p.G30S 11:32435054-32435054 9
4 COSM6972475 U2AF1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.103C>G p.R35G 21:43104344-43104344 9
5 COSM6927964 TP63 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1192G>A p.D398N 3:189869386-189869386 9
6 COSM6972463 TP63 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1046G>T p.G349V 3:189868633-189868633 9
7 COSM44076 TP53 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.655C>T p.P219S 17:7674876-7674876 9
8 COSM6972473 TOP1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.538G>C p.D180H 20:41084492-41084492 9
9 COSM6962629 TGFBR1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1323G>C p.M441I 9:99147721-99147721 9
10 COSM6982550 TENT5C upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.511G>C p.D171H 1:117623379-117623379 9
11 COSM6907202 SOX2 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.293G>A p.R98Q 3:181712653-181712653 9
12 COSM6962643 SMARCA4 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.935C>G p.S312C 19:10987741-10987741 9
13 COSM1014499 SF3B1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2104C>T p.R702W 2:197402104-197402104 9
14 COSM6962624 ROS1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.3763G>C p.D1255H 6:117357895-117357895 9
15 COSM6962644 PTPRT upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.4330G>A p.E1444K 20:42081890-42081890 9
16 COSM6982548 PIK3CD upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.73C>G p.L25V 1:9710528-9710528 9
17 COSM760 PIK3CA upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1624G>A p.E542K 3:179218294-179218294 9
18 COSM763 PIK3CA upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1633G>A p.E545K 3:179218303-179218303 9
19 COSM6961258 NFKBIA upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.153G>C p.E51D 14:35404492-35404492 9
20 COSM6961260 NFKBIA upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.95G>A p.S32N 14:35404550-35404550 9
21 COSM6975980 NFE2L2 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1507A>T p.R503W 2:177231096-177231096 9
22 COSM6982557 MET upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.3265A>G p.I1089V 7:116775063-116775063 9
23 COSM6962635 LATS2 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.316G>A p.E106K 13:21045711-21045711 9
24 COSM521 KRAS upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.35G>A p.G12D 12:25245350-25245350 9
25 COSM542 KRAS upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.53C>A p.A18D 12:25245332-25245332 9
26 COSM6962628 KMT2C upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.12022G>C p.E4008Q 7:152154384-152154384 9
27 COSM4125151 KIT upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1156G>A p.E386K 4:54709464-54709464 9
28 COSM94572 KEAP1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1085G>A p.R362Q 19:10491817-10491817 9
29 COSM6972470 KEAP1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.640-1G>A p.? 19:10492263-10492263 9
30 COSM6962632 KDM5A upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.3382G>A p.A1128T 12:308002-308002 9
31 COSM6961253 JAK1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2266A>T p.I756F 1:64844201-64844201 9
32 COSM6962640 INSR upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2542+1G>T p.? 19:7142815-7142815 9
33 COSM6962626 INHBA upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1094C>T p.S365L 7:41689837-41689837 9
34 COSM6962623 HIST1H3G upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.205C>A p.Q69K 6:26271180-26271180 9
35 COSM6972469 GPS2 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.509C>T p.A170V 17:7313693-7313693 9
36 COSM6960033 FOXA1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.288G>A p.M96I 14:37592496-37592496 9
37 COSM6972466 FLT1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.989-1G>C p.? 13:28430168-28430168 9
38 COSM27083 FBXW7 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2065C>T p.R689W 4:152322940-152322940 9
39 COSM3587776 EPHB1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.508C>T p.R170W 3:134951755-134951755 9
40 COSM6982554 EPHB1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1973C>T p.S658L 3:135192666-135192666 9
41 COSM5693798 EPHA7 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2251G>C p.D751H 6:93255959-93255959 9
42 COSM22952 EGFR upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2438A>G p.Y813C 7:55181447-55181447 9
43 COSM22954 EGFR upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2324G>A p.C775Y 7:55181333-55181333 9
44 COSM22953 EGFR upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.2401T>C p.Y801H 7:55181410-55181410 9
45 COSM3936685 DICER1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.4072C>T p.R1358C 14:95099914-95099914 9
46 COSM6982551 CXCR4 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.213G>C p.K71N 2:136115727-136115727 9
47 COSM6961254 CSF1R upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.1772G>A p.G591E 5:150061577-150061577 9
48 COSM6962636 CREBBP upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.4022G>C p.R1341P 16:3740510-3740510 9
49 COSM6962619 COP1 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.402C>G p.F134L 1:176206577-176206577 9
50 COSM6972471 CIC upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.247G>A p.E83K 19:42287035-42287035 9

Expression for Tonsil Squamous Cell Carcinoma

Search GEO for disease gene expression data for Tonsil Squamous Cell Carcinoma.

Pathways for Tonsil Squamous Cell Carcinoma

Pathways related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.15 MMP13 TIMP2
2 10.91 MMP13 TIMP2
3 10.41 MMP13 TIMP2

GO Terms for Tonsil Squamous Cell Carcinoma

Biological processes related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.26 HIST1H3B MMP13
2 aging GO:0007568 9.16 KRT16 TIMP2
3 epidermis development GO:0008544 8.96 EDA2R KRT16
4 extracellular matrix disassembly GO:0022617 8.62 MMP13 TIMP2

Sources for Tonsil Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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