MCID: TNS013
MIFTS: 25

Tonsil Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Tonsil Squamous Cell Carcinoma

MalaCards integrated aliases for Tonsil Squamous Cell Carcinoma:

Name: Tonsil Squamous Cell Carcinoma 12 15
Tonsillar Squamous Cell Carcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050920
UMLS 71 C0280317

Summaries for Tonsil Squamous Cell Carcinoma

Disease Ontology : 12 A tonsil cancer that has material basis in squamous cells.

MalaCards based summary : Tonsil Squamous Cell Carcinoma, also known as tonsillar squamous cell carcinoma, is related to tonsil cancer and oropharynx cancer. An important gene associated with Tonsil Squamous Cell Carcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Viral carcinogenesis and MicroRNAs in cancer. Affiliated tissues include tonsil, lymph node and tongue.

Related Diseases for Tonsil Squamous Cell Carcinoma

Graphical network of the top 20 diseases related to Tonsil Squamous Cell Carcinoma:



Diseases related to Tonsil Squamous Cell Carcinoma

Symptoms & Phenotypes for Tonsil Squamous Cell Carcinoma

Drugs & Therapeutics for Tonsil Squamous Cell Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bayesian Phase II Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer Recruiting NCT03224000 Phase 2

Search NIH Clinical Center for Tonsil Squamous Cell Carcinoma

Genetic Tests for Tonsil Squamous Cell Carcinoma

Anatomical Context for Tonsil Squamous Cell Carcinoma

MalaCards organs/tissues related to Tonsil Squamous Cell Carcinoma:

40
Tonsil, Lymph Node, Tongue, Liver, Thyroid, T Cells

Publications for Tonsil Squamous Cell Carcinoma

Articles related to Tonsil Squamous Cell Carcinoma:

(show top 50) (show all 157)
# Title Authors PMID Year
1
Risk of post-operative, pre-radiotherapy contralateral neck recurrence in patients treated with surgery followed by adjuvant radiotherapy for human papilloma virus-associated tonsil cancer. 61
31600090 2019
2
A global epidemic increase of an HPV-induced tonsil and tongue base cancer - potential benefit from a pan-gender use of HPV vaccine. 61
31733108 2019
3
Solitary cystic metastatic lymph node of occult human papillomavirus-related oropharyngeal cancer mimicking second branchial cleft cyst: A case report. 61
31689859 2019
4
CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear Translocation. 61
31627350 2019
5
Ipsilateral neck radiotherapy in N2b well-lateralized tonsil cancer - Approach with caution. 61
31059180 2019
6
Longus Capitis Reconstruction of the Soft Palate. 61
31084255 2019
7
Hypoglycemia associated with disseminated metastatic tonsillar squamous cell carcinoma producing insulin-like growth factor-I in a Pomeranian dog. 61
31280499 2019
8
[One case of metastatic lymph node presented sarcomatoid differentiation of tonsillar squamous cell carcinoma]. 61
31550766 2019
9
Electrochemotherapy in treatment of canine oral non-tonsillar squamous cell carcinoma. A case series report. 61
31419028 2019
10
Racial disparities in tumor features and outcomes of patients with squamous cell carcinoma of the tonsil. 61
30152118 2019
11
Survival outcome of tonsillar squamous cell carcinoma (TSCC) in the context of human papillomavirus (HPV): A systematic review and meta-analysis. 61
29843958 2019
12
Concurrent Squamous Cell Carcinoma and Chronic Lymphocytic Leukemia Presenting as an Enlarging Neck Mass. 61
31010317 2019
13
Atypical Metastasis of p16-Positive Tonsillar Squamous Cell Carcinoma to the Pleura: A Case Report. 61
30098955 2018
14
Combination of panendoscopy and positron emission tomography/computed tomography increases detection of unknown primary head and neck carcinoma. 61
30194842 2018
15
Clinical implication of programmed cell death-1 ligand-1 expression in tonsillar squamous cell carcinoma in association with intratumoral heterogeneity, human papillomavirus, and epithelial-to-mesenchymal transition. 61
29634978 2018
16
Occult tonsillar squamous cell carcinoma in 2 dogs presenting for treatment of primary oral squamous cell carcinoma. 61
30510311 2018
17
Distribution of Metastatic Nodes in N0-1 Patients with Tonsillar Squamous Cell Carcinoma and Its Implications for Selective Neck Dissection. 61
30319869 2018
18
Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis. 61
29553868 2018
19
Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma. 61
29573210 2018
20
Monocle tumor as tonsillar squamous cell carcinoma metastasis: resolution after chemotherapy treatment. 61
29369338 2018
21
Staging Neck Dissection and Transoral Robotic Surgery Treatment Algorithm in Palatine Tonsil Cancer. 61
29160154 2018
22
The incidence of malignancy in clinically benign cystic lesions of the lateral neck: our experience and proposed diagnostic algorithm. 61
29282522 2018
23
Prevalence of synchronous bilateral tonsil squamous cell carcinoma: A retrospective study. 61
28891195 2018
24
Metastasis to the thyroid gland from a tonsil squamous cell carcinoma. 61
30264003 2018
25
Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma. 61
29338018 2018
26
Fanconi anaemia presenting as tonsillar squamous cell carcinoma. 61
29749370 2018
27
Risk of contralateral nodal failure following ipsilateral IMRT for node-positive tonsillar cancer. 61
29224820 2017
28
Synchronous, bilateral tonsillar carcinomas: Patient characteristics and human papillomavirus genotypes. 61
29103737 2017
29
Metastatic tonsillar squamous cell carcinoma masquerading as a pancreatic cystic tumor and diagnosed by EUS-guided FNA. 61
28631390 2017
30
Comparison of the Clinical Outcomes of Patients with Squamous Cell Carcinoma of the Tonsil Receiving Postoperative Ipsilateral Versus Bilateral Neck Radiotherapy: A Propensity Score Matching Analysis (KROG 11-07). 61
28183163 2017
31
Endobronchial Metastasis from Extrapulmonary Neoplasms: Analysis of Clinicopathologic Features and Cytological Evaluation by Bronchial Brushing. 61
28555346 2017
32
Multimodality Treatment of Early-Stage Tonsil Cancer. 61
28669307 2017
33
Systemic matrix metalloproteinase-8 response in chronic tonsillitis. 61
27804311 2017
34
Human polyomavirus and human papillomavirus prevalence and viral load in non-malignant tonsillar tissue and tonsillar carcinoma. 61
27832373 2017
35
Cutaneous Metastasis From Tonsillar Squamous Cell Carcinoma: Report and Review of the Literature. 61
28465869 2017
36
Adjuvant radiation in the TORS era: Is there a benefit to omitting the tumor bed? 61
28274400 2017
37
HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma. 61
28607924 2017
38
Continuing rise in oropharyngeal cancer in a high HPV prevalence area: A Danish population-based study from 2011 to 2014. 61
27888679 2017
39
No evidence for the presence of Epstein-Barr virus in squamous cell carcinoma of the mobile tongue. 61
28926591 2017
40
Double positivity for HPV DNA/p16 in tonsillar and base of tongue cancer improves prognostication: Insights from a large population-based study. 61
27537425 2016
41
Minimal benefit of tonsillectomy in T1-T2 tonsillar squamous cell carcinoma treated with chemoradiotherapy. 61
27449724 2016
42
Radiotherapy alone or combined with chemotherapy as definitive treatment for squamous cell carcinoma of the tonsil. 61
27059836 2016
43
Tonsillar Squamous Cell Carcinoma: An Additional Consideration for Atypical Glossodynia. 61
28437054 2016
44
Evaluation of the factors contributing to long-term survival in canine tonsillar squamous cell carcinoma. 61
27237121 2016
45
In this issue - June 2016: High-quality care improves outcome in recumbent dairy cattle · Corneal anaesthesia in clinically normal cattle · Severe hyponatraemia in foals · Ultrasonographically visible hepatic location in clinically normal horses · Long-term survival in canine tonsillar squamous cell carcinoma · Treatment of oral squamous cell carcinoma in an inshore bottlenose dolphin · Alphaherpesvirus-associated disease in greater bilbies. 61
27237116 2016
46
Human papillomavirus in tonsillar squamous cell carcinomas from Guatemala and Brazil. 61
26972540 2016
47
Synchronous bilateral tonsillar squamous cell carcinoma related to human papillomavirus: Two case reports and a brief review of the literature. 61
27140027 2016
48
Histogram Analysis of Apparent Diffusion Coefficients for Occult Tonsil Cancer in Patients with Cervical Nodal Metastasis from an Unknown Primary Site at Presentation. 61
26115452 2016
49
Composition of inflammatory cells regulating the response to concurrent chemoradiation therapy for HPV (+) tonsil cancer. 61
26475063 2015
50
Molecular Pathogenesis of Human Papillomavirus Type 16 in Tonsillar Squamous Cell Carcinoma. 61
26637879 2015

Variations for Tonsil Squamous Cell Carcinoma

Cosmic variations for Tonsil Squamous Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM112550399 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.197C>G p.S66* 12:45852496-45852496 0

Expression for Tonsil Squamous Cell Carcinoma

Search GEO for disease gene expression data for Tonsil Squamous Cell Carcinoma.

Pathways for Tonsil Squamous Cell Carcinoma

Pathways related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 H2BC14 CDKN2A CCND1
2 11.42 MIR363 MIR193B CDKN2A CCND1
3 10.86 CDKN2A CCND1

GO Terms for Tonsil Squamous Cell Carcinoma

Sources for Tonsil Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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