Tonsil Squamous Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: TNS013 MIFTS: 32	Tonsil Squamous Cell Carcinoma Categories: Cancer diseases, Gastrointestinal diseases, Immune diseases
Genes Variations Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Tonsil Squamous Cell Carcinoma

MalaCards integrated aliases for Tonsil Squamous Cell Carcinoma:

Name: Tonsil Squamous Cell Carcinoma ¹² ¹⁵

Tonsillar Squamous Cell Carcinoma ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050920

UMLS ⁷¹ C0280317

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Summaries for Tonsil Squamous Cell Carcinoma

Disease Ontology : ¹² A tonsil cancer that has material basis in squamous cells.

MalaCards based summary : Tonsil Squamous Cell Carcinoma, also known as tonsillar squamous cell carcinoma, is related to tonsil cancer and oropharynx cancer. An important gene associated with Tonsil Squamous Cell Carcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are ERK Signaling and Gene Expression. Affiliated tissues include tonsil, lymph node and tongue.

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Related Diseases for Tonsil Squamous Cell Carcinoma

Diseases related to Tonsil Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)

#	Related Disease	Score	Top Affiliating Genes
1	tonsil cancer	30.3	MIR193B CDKN2A
2	oropharynx cancer	30.1	MIR193B CDKN2A CCND1
3	squamous cell carcinoma	10.6
4	bowenoid papulosis	10.3	CDKN2A CCND1
5	esophagus verrucous carcinoma	10.3	CDKN2A CCND1
6	verrucous carcinoma	10.3	CDKN2A CCND1
7	bone squamous cell carcinoma	10.3	CDKN2A CCND1
8	chondromyxoid fibroma	10.3	CDKN2A CCND1
9	laryngeal benign neoplasm	10.3	CDKN2A CCND1
10	nodular malignant melanoma	10.2	CDKN2A CCND1
11	rhabdoid cancer	10.2	CDKN2A CCND1
12	respiratory system benign neoplasm	10.2	CDKN2A CCND1
13	inverted papilloma	10.2	CDKN2A CCND1
14	esophagus adenocarcinoma	10.1	CDKN2A CCND1
15	vulva cancer	10.1	CDKN2A CCND1
16	peripheral nervous system neoplasm	10.0	MIR193B CDKN2A CCND1
17	barrett esophagus	10.0	MIR193B CDKN2A CCND1
18	suppressor of tumorigenicity 3	10.0
19	mucositis	10.0
20	sensory peripheral neuropathy	10.0
21	neuropathy	10.0
22	desmoid tumor	10.0	CDKN2A CCND1
23	pilocytic astrocytoma of cerebellum	10.0	H3C11 H3C10
24	melanoma, uveal	10.0	MIR193B CDKN2A CCND1
25	reproductive organ benign neoplasm	9.8	CDKN2A CCND1
26	cerebellar astrocytoma	9.5	H3C12 H3C11 H3C10
27	glioma	9.3	H3C11 H3C1 CDKN2A CCND1
28	adult infiltrating astrocytic neoplasm	8.6	H3C7 H3C12 H3C11 H3C10 H3C1
29	childhood brain stem glioma	8.5	H3C7 H3C12 H3C11 H3C10 H3C1
30	brain stem cancer	8.5	H3C7 H3C12 H3C11 H3C10 H3C1
31	pilomyxoid astrocytoma	8.5	H3C7 H3C12 H3C11 H3C10 H3C1
32	brain stem glioma	8.4	H3C7 H3C12 H3C11 H3C10 H3C1 CDKN2A
33	infratentorial cancer	8.3	H3C7 H3C12 H3C11 H3C10 H3C1 CCND1
34	glioblastoma multiforme	8.1	H3C7 H3C12 H3C11 H3C10 H3C1 CDKN2A

Graphical network of the top 20 diseases related to Tonsil Squamous Cell Carcinoma:

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Symptoms & Phenotypes for Tonsil Squamous Cell Carcinoma

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Drugs & Therapeutics for Tonsil Squamous Cell Carcinoma

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Bayesian Phase II Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer	Recruiting	NCT03224000	Phase 2

Search NIH Clinical Center for Tonsil Squamous Cell Carcinoma

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Genetic Tests for Tonsil Squamous Cell Carcinoma

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Anatomical Context for Tonsil Squamous Cell Carcinoma

MalaCards organs/tissues related to Tonsil Squamous Cell Carcinoma:

⁴⁰

Tonsil, Lymph Node, Tongue, Brain, Liver, Thyroid, Pituitary

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Publications for Tonsil Squamous Cell Carcinoma

Articles related to Tonsil Squamous Cell Carcinoma:

(show top 50) (show all 163)

#	Title	Authors	PMID	Year
1	Comparative cost of transoral robotic surgery and radiotherapy (IMRT) in early stage tonsil cancer. ⁶¹	Spellman J...Calzada G	32057489	2020
2	Left atrial tumor thrombus with emboli to the brain and distal extremities: A case report. ⁶¹	Layfield LJ...Crim JR	32178936	2020
3	Canine tonsillar neoplasia and tonsillar metastasis from various primary neoplasms. ⁶¹	Mickelson MA...Seguin B	32352191	2020
4	Isolated pituitary fossa metastasis from a primary tonsillar squamous cell carcinoma: case report. ⁶¹	Merchant H...Smith JA	32234087	2020
5	A global epidemic increase of an HPV-induced tonsil and tongue base cancer - potential benefit from a pan-gender use of HPV vaccine. ⁶¹	Nasman A...Dalianis T	31733108	2020
6	The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis. ⁶¹	Carey RM...Robertson ES	32076488	2020
7	Risk of post-operative, pre-radiotherapy contralateral neck recurrence in patients treated with surgery followed by adjuvant radiotherapy for human papilloma virus-associated tonsil cancer. ⁶¹	Gershowitz J...Lin A	31600090	2019
8	Solitary cystic metastatic lymph node of occult human papillomavirus-related oropharyngeal cancer mimicking second branchial cleft cyst: A case report. ⁶¹	Liang HH...Chan WP	31689859	2019
9	CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear Translocation. ⁶¹	Shin SP...Lee SJ	31627350	2019
10	Ipsilateral neck radiotherapy in N2b well-lateralized tonsil cancer - Approach with caution. ⁶¹	Maskell D...Geropantas K	31059180	2019
11	Hypoglycemia associated with disseminated metastatic tonsillar squamous cell carcinoma producing insulin-like growth factor-I in a Pomeranian dog. ⁶¹	Azuma K...Goto Asakawa M	31280499	2019
12	Longus Capitis Reconstruction of the Soft Palate. ⁶¹	Gross JH...Pipkorn P	31084255	2019
13	[One case of metastatic lymph node presented sarcomatoid differentiation of tonsillar squamous cell carcinoma]. ⁶¹	Gao X...Li YT	31550766	2019
14	Electrochemotherapy in treatment of canine oral non-tonsillar squamous cell carcinoma. A case series report. ⁶¹	Simcic P...Lubas G	31419028	2019
15	Racial disparities in tumor features and outcomes of patients with squamous cell carcinoma of the tonsil. ⁶¹	Albert A...Vijayakumar S	30152118	2019
16	Survival outcome of tonsillar squamous cell carcinoma (TSCC) in the context of human papillomavirus (HPV): A systematic review and meta-analysis. ⁶¹	Ahmadi N...Chin RY	29843958	2019
17	Pigmented Villonodular Synovitis Masquerading as a Metastasis: Imaging Features and Coaxial Needle Biopsy Technique. ⁶¹	Rajakulasingam R...Botchu R	32577111	2019
18	Concurrent Squamous Cell Carcinoma and Chronic Lymphocytic Leukemia Presenting as an Enlarging Neck Mass. ⁶¹	Bhinder P...Zuberi L	31010317	2019
19	Atypical Metastasis of p16-Positive Tonsillar Squamous Cell Carcinoma to the Pleura: A Case Report. ⁶¹	LeRose CC...Ramirez CA	30098955	2018
20	Combination of panendoscopy and positron emission tomography/computed tomography increases detection of unknown primary head and neck carcinoma. ⁶¹	Sokoya M...Ducic Y	30194842	2018
21	Occult tonsillar squamous cell carcinoma in 2 dogs presenting for treatment of primary oral squamous cell carcinoma. ⁶¹	Rancilio NJ...Fulkerson CM	30510311	2018
22	Clinical implication of programmed cell death-1 ligand-1 expression in tonsillar squamous cell carcinoma in association with intratumoral heterogeneity, human papillomavirus, and epithelial-to-mesenchymal transition. ⁶¹	Kwon MJ...Min KW	29634978	2018
23	Distribution of Metastatic Nodes in N0-1 Patients with Tonsillar Squamous Cell Carcinoma and Its Implications for Selective Neck Dissection. ⁶¹	Kohler HF...Kowalski LP	30319869	2018
24	Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis. ⁶¹	Park S...Song JS	29553868	2018
25	Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma. ⁶¹	Haeggblom L...Nasman A	29573210	2018
26	Monocle tumor as tonsillar squamous cell carcinoma metastasis: resolution after chemotherapy treatment. ⁶¹	Lobato-Berezo A...Moya-Horno I	29369338	2018
27	Staging Neck Dissection and Transoral Robotic Surgery Treatment Algorithm in Palatine Tonsil Cancer. ⁶¹	Spellman J...Calzada G	29160154	2018
28	The incidence of malignancy in clinically benign cystic lesions of the lateral neck: our experience and proposed diagnostic algorithm. ⁶¹	Yehuda M...Abu-Ghanem S	29282522	2018
29	Prevalence of synchronous bilateral tonsil squamous cell carcinoma: A retrospective study. ⁶¹	Rokkjaer MS...Klug TE	28891195	2018
30	Metastasis to the thyroid gland from a tonsil squamous cell carcinoma. ⁶¹	Gumaa D...Mihai R	30264003	2018
31	Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma. ⁶¹	Marcussen M...Johnsen HE	29338018	2018
32	Fanconi anaemia presenting as tonsillar squamous cell carcinoma. ⁶¹	Sarma YS...Sriharibabu M	29749370	2018
33	Risk of contralateral nodal failure following ipsilateral IMRT for node-positive tonsillar cancer. ⁶¹	Gottumukkala S...Sher DJ	29224820	2017
34	Synchronous, bilateral tonsillar carcinomas: Patient characteristics and human papillomavirus genotypes. ⁶¹	Nami Saber C...von Buchwald C	29103737	2017
35	Metastatic tonsillar squamous cell carcinoma masquerading as a pancreatic cystic tumor and diagnosed by EUS-guided FNA. ⁶¹	Glass R...Tong GX	28631390	2017
36	Endobronchial Metastasis from Extrapulmonary Neoplasms: Analysis of Clinicopathologic Features and Cytological Evaluation by Bronchial Brushing. ⁶¹	Ikemura K...Gattuso P	28555346	2017
37	Comparison of the Clinical Outcomes of Patients with Squamous Cell Carcinoma of the Tonsil Receiving Postoperative Ipsilateral Versus Bilateral Neck Radiotherapy: A Propensity Score Matching Analysis (KROG 11-07). ⁶¹	Kim Y...Oh YT	28183163	2017
38	Multimodality Treatment of Early-Stage Tonsil Cancer. ⁶¹	Roden DF...Givi B	28669307	2017
39	Systemic matrix metalloproteinase-8 response in chronic tonsillitis. ⁶¹	Ilmarinen T...Aaltonen LM	27804311	2017
40	Human polyomavirus and human papillomavirus prevalence and viral load in non-malignant tonsillar tissue and tonsillar carcinoma. ⁶¹	Herberhold S...Wieland U	27832373	2017
41	Adjuvant radiation in the TORS era: Is there a benefit to omitting the tumor bed? ⁶¹	Lazarev S...Bakst RL	28274400	2017
42	Cutaneous Metastasis From Tonsillar Squamous Cell Carcinoma: Report and Review of the Literature. ⁶¹	Bari O...Cohen PR	28465869	2017
43	Continuing rise in oropharyngeal cancer in a high HPV prevalence area: A Danish population-based study from 2011 to 2014. ⁶¹	Carlander AF...von Buchwald C	27888679	2017
44	No evidence for the presence of Epstein-Barr virus in squamous cell carcinoma of the mobile tongue. ⁶¹	Wilms T...Nylander K	28926591	2017
45	HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma. ⁶¹	Kwon MJ...Rho YS	28607924	2017
46	Double positivity for HPV DNA/p16 in tonsillar and base of tongue cancer improves prognostication: Insights from a large population-based study. ⁶¹	Garnaes E...von Buchwald C	27537425	2016
47	Minimal benefit of tonsillectomy in T1-T2 tonsillar squamous cell carcinoma treated with chemoradiotherapy. ⁶¹	Chao YT...Tai SK	27449724	2016
48	Radiotherapy alone or combined with chemotherapy as definitive treatment for squamous cell carcinoma of the tonsil. ⁶¹	Kennedy WR...Mendenhall WM	27059836	2016
49	Tonsillar Squamous Cell Carcinoma: An Additional Consideration for Atypical Glossodynia. ⁶¹	Rathore S...Desai B	28437054	2016
50	Evaluation of the factors contributing to long-term survival in canine tonsillar squamous cell carcinoma. ⁶¹	Grant J...North S	27237121	2016

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Genes for Tonsil Squamous Cell Carcinoma

Genes related to Tonsil Squamous Cell Carcinoma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	11.64	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	19305381
2	CCND1	Cyclin D1	Protein Coding	7.08	Novoseek inferred ⁵⁴	19305381
3	H2BC14	H2B Clustered Histone 14	Protein Coding	6.7	DISEASES inferred ¹⁵
4	SYCP2	Synaptonemal Complex Protein 2	Protein Coding	6.13	DISEASES inferred ¹⁵
5	MIR193B	MicroRNA 193b	RNA Gene	5.85	DISEASES inferred ¹⁵
6	H1-5	H1.5 Linker Histone, Cluster Member	Protein Coding	5.32	DISEASES inferred ¹⁵
7	H1-1	H1.1 Linker Histone, Cluster Member	Protein Coding	5.26	DISEASES inferred ¹⁵
8	H3C10	H3 Clustered Histone 10	Protein Coding	5.22	DISEASES inferred ¹⁵
9	H3C11	H3 Clustered Histone 11	Protein Coding	5.22	DISEASES inferred ¹⁵
10	H3C12	H3 Clustered Histone 12	Protein Coding	5.22	DISEASES inferred ¹⁵
11	H3C1	H3 Clustered Histone 1	Protein Coding	5.21	DISEASES inferred ¹⁵
12	H3C7	H3 Clustered Histone 7	Protein Coding	5.21	DISEASES inferred ¹⁵

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Variations for Tonsil Squamous Cell Carcinoma

Cosmic variations for Tonsil Squamous Cell Carcinoma:

⁹

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM112550399		upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma	c.197C>G	p.S66*	12:45852496-45852496	0

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Expression for Tonsil Squamous Cell Carcinoma

Search GEO for disease gene expression data for Tonsil Squamous Cell Carcinoma.

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Pathways for Tonsil Squamous Cell Carcinoma

Pathways related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 28)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.6	H3C7 H3C12 H3C11 H3C10 H3C1 CDKN2A
2	Gene Expression ⁶⁵ Show member pathways Generic Transcription Pathway ⁶⁵	13.59	H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
3	Metabolism of proteins ⁶⁵ Show member pathways Post-translational protein modification ⁶⁵	13.57	H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
4	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 ⁶⁵ Show member pathways Activation of anterior HOX genes in hindbrain development during early embryogenesis ⁶⁵ Activation of HOX genes during differentiation ⁶⁵ Alcoholism ³⁶ Amyloid fiber formation ⁶⁵ B-WICH complex positively regulates rRNA expression ⁶⁵ Condensation of Prophase Chromosomes ⁶⁵ DNA methylation ⁶⁵ Epigenetic regulation of gene expression ⁶⁵ ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression ⁶⁵ Formation of the beta-catenin-TCF transactivating complex ⁶⁵ HDACs deacetylate histones ⁶⁵ HDMs demethylate histones ⁶⁵ Negative epigenetic regulation of rRNA expression ⁶⁵ NoRC negatively regulates rRNA expression ⁶⁵ Positive epigenetic regulation of rRNA expression ⁶⁵ PRC2 methylates histones and DNA ⁶⁵ RHO GTPases activate PKNs ⁶⁵ RMTs methylate histone arginines ⁶⁵ RNA Polymerase I Chain Elongation ⁶⁵ RNA Polymerase I Promoter Clearance ⁶⁵ RNA Polymerase I Promoter Opening ⁶⁵ RNA Polymerase I Transcription ⁶⁵ RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription ⁶⁵ SIRT1 negatively regulates rRNA Expression ⁶⁵ Systemic lupus erythematosus ³⁶	13.56	H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
5	Activation of cAMP-Dependent PKA ⁶³ Show member pathways Activation of PKA through GPCR ⁶³ cAMP Pathway ⁶³ PKA Signaling ⁶³	13.35	H3C7 H3C12 H3C11 H3C10 H3C1 H1-5
6	Developmental Biology ⁶⁵ Show member pathways Axon guidance ⁶⁵	13.28	H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
7	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.14	H3C7 H3C12 H3C11 H3C10 H3C1 CCND1
8	Cell Cycle, Mitotic ⁶⁵ Show member pathways Cell Cycle ⁶⁵ M Phase ⁶⁵	13.13	SYCP2 H3C7 H3C12 H3C11 H3C10 H3C1
9	Response to elevated platelet cytosolic Ca2+ ⁶⁵ Show member pathways Disinhibition of SNARE formation ⁶⁵ Hemostasis ⁶⁵ Platelet activation, signaling and aggregation ⁶⁵ Platelet degranulation ⁶⁵	13.11	H3C7 H3C12 H3C11 H3C10 H3C1
10	Signaling by Rho GTPases ⁶⁵ Show member pathways RHO GTPase Effectors ⁶⁵	12.87	H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
11	Chromatin organization ⁶⁵ Show member pathways Chromatin modifying enzymes ⁶⁵ HATs acetylate histones ⁶⁵	12.85	H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
12	RNA Polymerase II Transcription Initiation And Promoter Clearance ⁶⁵ Show member pathways Assembly of RNA Polymerase-II Initiation Complex ⁶³ Basal transcription factors ³⁶ Crosstalk Between CARM1 and ESRs ⁶³ Eukaryotic Transcription Initiation ¹ HIV Transcription Initiation ⁶⁵ Protein Acetylation and Deacetylation ⁶³ RNA Polymerase II HIV Promoter Escape ⁶⁵ RNA Polymerase II Promoter Escape ⁶⁵ RNA Polymerase II Transcription Initiation ⁶⁵ RNA Polymerase II Transcription Pre-Initiation And Promoter Opening ⁶⁵ Transcription Ligand-Dependent Transcription of Retinoid-Target genes ²² Transcription of mRNA ⁶³	12.83	H3C7 H3C12 H3C11 H3C10 H3C1
13	Signaling by Wnt ⁶⁵ Show member pathways TCF dependent signaling in response to WNT ⁶⁵	12.76	H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
14	Mitotic Prophase ⁶⁵ Show member pathways Gene Silencing by RNA ⁶⁵ Golgi Cisternae Pericentriolar Stack Reorganization ⁶⁵ MASTL Facilitates Mitotic Progression ⁶⁵ Small interfering RNA (siRNA) biogenesis ⁶⁵ Transcriptional regulation by small RNAs ⁶⁵	12.58	H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
15	Cellular Senescence (REACTOME) ⁶⁵ Show member pathways Cellular Senescence ⁶⁵ Oxidative Stress Induced Senescence ⁶⁵ Senescence-Associated Secretory Phenotype (SASP) ⁶⁵	12.56	H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
16	Shigellosis ³⁶	12.29	H3C7 H3C12 H3C11 H3C10 H3C1
17	Transcriptional misregulation in cancer ³⁶	12.18	H3C7 H3C12 H3C11 H3C10 H3C1
18	DNA Damage/Telomere Stress Induced Senescence ⁶⁵ Show member pathways Formation of Senescence-Associated Heterochromatin Foci (SAHF) ⁶⁵ Packaging Of Telomere Ends ⁶⁵ Signal transduction Activin A signaling regulation ²²	12.16	H2BC14 H1-5 H1-1
19	Meiosis ⁶⁵ Show member pathways Meiotic recombination ⁶⁵ Meiotic synapsis ⁶⁵	12.16	SYCP2 H3C7 H3C12 H3C11 H3C10 H3C1
20	Viral carcinogenesis ³⁶	12.11	H2BC14 CDKN2A CCND1
21	Factors involved in megakaryocyte development and platelet production ⁶⁵	12.03	H3C7 H3C12 H3C11 H3C10 H3C1
22	PKMTs methylate histone lysines ⁶⁵ Show member pathways Histone Modifications ¹	11.92	H3C7 H3C12 H3C11 H3C10 H3C1
23	UVA-Induced MAPK Signaling ⁶³ Show member pathways UVB-Induced MAPK Signaling ⁶³	11.91	H3C7 H3C12 H3C11 H3C10 H3C1
24	Interferon Pathway ⁶³	11.61	H3C7 H3C12 H3C11 H3C10 H3C1
25	Cell cycle_Chromosome condensation in prometaphase ²²	11.15	H1-5 H1-1
26	Apoptosis induced DNA fragmentation ⁶⁵ Show member pathways Activation of DNA fragmentation factor ⁶⁵	11.03	H1-5 H1-1
27	Granzyme-A Pathway ⁶³	10.78	H1-5 H1-1
28	Interleukin-7 signaling ⁶⁵	10.47	H3C7 H3C12 H3C11 H3C10 H3C1

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GO Terms for Tonsil Squamous Cell Carcinoma

Cellular components related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:0005634	10.06	SYCP2 H3C7 H3C12 H3C11 H3C10 H3C1
2	nucleoplasm	GO:0005654	10.03	H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
3	extracellular exosome	GO:0070062	9.95	MIR193B H3C7 H3C12 H3C11 H3C10 H3C1
4	protein-containing complex	GO:0032991	9.77	H3C7 H3C12 H3C11 H3C10 H3C1
5	nuclear chromosome	GO:0000228	9.65	H3C7 H3C12 H3C11 H3C10 H3C1
6	host cell nucleus	GO:0042025	9.63	H1-5 H1-1 CCND1
7	chromosome	GO:0005694	9.61	SYCP2 H3C7 H3C12 H3C11 H3C10 H3C1
8	nuclear nucleosome	GO:0000788	9.55	H3C7 H3C12 H3C11 H3C10 H3C1
9	nuclear euchromatin	GO:0005719	9.48	H1-5 H1-1
10	nucleosome	GO:0000786	9.23	H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14

Biological processes related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatin organization	GO:0006325	9.95	H3C7 H3C12 H3C11 H3C10 H3C1 H1-5
2	cellular protein metabolic process	GO:0044267	9.91	H3C7 H3C12 H3C11 H3C10 H3C1
3	blood coagulation	GO:0007596	9.89	H3C7 H3C12 H3C11 H3C10 H3C1
4	regulation of gene silencing by miRNA	GO:0060964	9.85	H3C7 H3C12 H3C11 H3C10 H3C1
5	regulation of megakaryocyte differentiation	GO:0045652	9.83	H3C7 H3C12 H3C11 H3C10 H3C1
6	negative regulation of gene expression, epigenetic	GO:0045814	9.8	H3C7 H3C12 H3C11 H3C10 H3C1
7	chromatin silencing at rDNA	GO:0000183	9.77	H3C7 H3C12 H3C11 H3C10 H3C1
8	DNA replication-dependent nucleosome assembly	GO:0006335	9.72	H3C7 H3C12 H3C11 H3C10 H3C1
9	interleukin-7-mediated signaling pathway	GO:0038111	9.65	H3C7 H3C12 H3C11 H3C10 H3C1
10	chromosome condensation	GO:0030261	9.56	H1-5 H1-1
11	negative regulation of DNA recombination	GO:0045910	9.55	H1-5 H1-1
12	telomere organization	GO:0032200	9.55	H3C7 H3C12 H3C11 H3C10 H3C1
13	nucleosome positioning	GO:0016584	9.54	H1-5 H1-1
14	negative regulation of chromatin silencing	GO:0031936	9.52	H1-5 H1-1
15	regulation of gene silencing	GO:0060968	9.35	H3C7 H3C12 H3C11 H3C10 H3C1
16	nucleosome assembly	GO:0006334	9.23	H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14

Molecular functions related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cadherin binding	GO:0045296	9.55	H3C7 H3C12 H3C11 H3C10 H3C1
2	protein heterodimerization activity	GO:0046982	9.43	H3C7 H3C12 H3C11 H3C10 H3C1 H2BC14
3	DNA binding	GO:0003677	9.32	SYCP2 H3C7 H3C12 H3C11 H3C10 H3C1
4	nucleosomal DNA binding	GO:0031492	9.26	H1-5 H1-1

Sources

Sources for Tonsil Squamous Cell Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia