MCID: TNS013
MIFTS: 28

Tonsil Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Tonsil Squamous Cell Carcinoma

MalaCards integrated aliases for Tonsil Squamous Cell Carcinoma:

Name: Tonsil Squamous Cell Carcinoma 12 15
Tonsillar Squamous Cell Carcinoma 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0050920
UMLS 72 C0280317

Summaries for Tonsil Squamous Cell Carcinoma

Disease Ontology : 12 A tonsil cancer that has material basis in squamous cells.

MalaCards based summary : Tonsil Squamous Cell Carcinoma, also known as tonsillar squamous cell carcinoma, is related to oropharynx cancer and squamous cell carcinoma. An important gene associated with Tonsil Squamous Cell Carcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are DNA Damage Response (only ATM dependent) and Glioblastoma Multiforme. Affiliated tissues include tonsil, lymph node and tongue.

Related Diseases for Tonsil Squamous Cell Carcinoma

Diseases related to Tonsil Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 oropharynx cancer 30.3 CDKN2A CCND1
2 squamous cell carcinoma 10.5
3 breast papillomatosis 10.2 CDKN2A CCND1
4 papilloma 10.2 CDKN2A CCND1
5 bowenoid papulosis 10.2 CDKN2A CCND1
6 skin carcinoma in situ 10.2 CDKN2A CCND1
7 endometrial squamous cell carcinoma 10.2 CDKN2A CCND1
8 oral leukoplakia 10.2 CDKN2A CCND1
9 ischemic fasciitis 10.2 CDKN2A CCND1
10 nasal cavity squamous cell carcinoma 10.2 TIMP2 CDKN2A
11 verrucous carcinoma 10.2 CDKN2A CCND1
12 pre-malignant neoplasm 10.2 CDKN2A CCND1
13 chondromyxoid fibroma 10.2 CDKN2A CCND1
14 pharynx cancer 10.2 CDKN2A CCND1
15 laryngeal disease 10.2 CDKN2A CCND1
16 inverted papilloma 10.2 CDKN2A CCND1
17 penile cancer 10.2 CDKN2A CCND1
18 nasopharyngeal disease 10.2 CDKN2A CCND1
19 retinal cancer 10.2 CDKN2A CCND1
20 esophageal disease 10.2 CDKN2A CCND1
21 cervix disease 10.2 CDKN2A CCND1
22 tonsil cancer 10.1
23 ocular cancer 10.1 CDKN2A CCND1
24 uterine anomalies 10.1 CDKN2A CCND1
25 bladder disease 10.1 CDKN2A CCND1
26 tongue cancer 10.1 CDKN2A CCND1
27 laryngeal squamous cell carcinoma 10.1 CDKN2A CCND1
28 oral cancer 10.1 CDKN2A CCND1
29 female reproductive system disease 10.1 CDKN2A CCND1
30 reproductive system disease 10.1 CDKN2A CCND1
31 nervous system cancer 10.1 CDKN2A CCND1
32 respiratory system cancer 10.1 CDKN2A CCND1
33 gastrointestinal system cancer 10.0 CDKN2A CCND1
34 endocrine gland cancer 10.0 CDKN2A CCND1
35 suppressor of tumorigenicity 3 10.0
36 mucositis 10.0
37 sensory peripheral neuropathy 10.0
38 neuropathy 10.0
39 larynx cancer 10.0 CDKN2A CCND1
40 gastrointestinal system disease 10.0 CDKN2A CCND1
41 mantle cell lymphoma 9.9 CDKN2A CCND1
42 lynch syndrome 9.9 CDKN2A CCND1
43 sorsby fundus dystrophy 9.9 TIMP2 MMP13
44 barrett esophagus 9.8 CDKN2A CCND1
45 aortic aneurysm, familial abdominal, 1 9.8 TIMP2 MMP13
46 inguinal hernia 9.8 TIMP2 MMP13
47 adamantinoma of long bones 9.7 TIMP2 CDKN2A CCND1
48 gallbladder cancer 9.7 TIMP2 CDKN2A
49 gastric adenocarcinoma 9.7 TIMP2 CDKN2A CCND1
50 endometrial cancer 9.5 TIMP2 CDKN2A CCND1

Graphical network of the top 20 diseases related to Tonsil Squamous Cell Carcinoma:



Diseases related to Tonsil Squamous Cell Carcinoma

Symptoms & Phenotypes for Tonsil Squamous Cell Carcinoma

Drugs & Therapeutics for Tonsil Squamous Cell Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bayesian Phase II Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer Recruiting NCT03224000 Phase 2

Search NIH Clinical Center for Tonsil Squamous Cell Carcinoma

Genetic Tests for Tonsil Squamous Cell Carcinoma

Anatomical Context for Tonsil Squamous Cell Carcinoma

MalaCards organs/tissues related to Tonsil Squamous Cell Carcinoma:

41
Tonsil, Lymph Node, Tongue, Liver, Thyroid, T Cells

Publications for Tonsil Squamous Cell Carcinoma

Articles related to Tonsil Squamous Cell Carcinoma:

(show top 50) (show all 152)
# Title Authors PMID Year
1
Ipsilateral neck radiotherapy in N2b well-lateralized tonsil cancer - Approach with caution. 38
31059180 2019
2
Electrochemotherapy in treatment of canine oral non-tonsillar squamous cell carcinoma. a case series report. 38
31419028 2019
3
Hypoglycemia associated with disseminated metastatic tonsillar squamous cell carcinoma producing insulin-like growth factor-I in a Pomeranian dog. 38
31280499 2019
4
Longus Capitis Reconstruction of the Soft Palate. 38
31084255 2019
5
Racial disparities in tumor features and outcomes of patients with squamous cell carcinoma of the tonsil. 38
30152118 2019
6
Survival outcome of tonsillar squamous cell carcinoma (TSCC) in the context of human papillomavirus (HPV): A systematic review and meta-analysis. 38
29843958 2019
7
Concurrent Squamous Cell Carcinoma and Chronic Lymphocytic Leukemia Presenting as an Enlarging Neck Mass. 38
31010317 2019
8
Atypical Metastasis of p16-Positive Tonsillar Squamous Cell Carcinoma to the Pleura: A Case Report. 38
30098955 2018
9
Combination of panendoscopy and positron emission tomography/computed tomography increases detection of unknown primary head and neck carcinoma. 38
30194842 2018
10
Clinical implication of programmed cell death-1 ligand-1 expression in tonsillar squamous cell carcinoma in association with intratumoral heterogeneity, human papillomavirus, and epithelial-to-mesenchymal transition. 38
29634978 2018
11
Occult tonsillar squamous cell carcinoma in 2 dogs presenting for treatment of primary oral squamous cell carcinoma. 38
30510311 2018
12
Distribution of Metastatic Nodes in N0-1 Patients with Tonsillar Squamous Cell Carcinoma and Its Implications for Selective Neck Dissection. 38
30319869 2018
13
Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis. 38
29553868 2018
14
Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma. 38
29573210 2018
15
Monocle tumor as tonsillar squamous cell carcinoma metastasis: resolution after chemotherapy treatment. 38
29369338 2018
16
Staging Neck Dissection and Transoral Robotic Surgery Treatment Algorithm in Palatine Tonsil Cancer. 38
29160154 2018
17
The incidence of malignancy in clinically benign cystic lesions of the lateral neck: our experience and proposed diagnostic algorithm. 38
29282522 2018
18
Prevalence of synchronous bilateral tonsil squamous cell carcinoma: A retrospective study. 38
28891195 2018
19
Metastasis to the thyroid gland from a tonsil squamous cell carcinoma. 38
30264003 2018
20
Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma. 38
29338018 2018
21
Fanconi anaemia presenting as tonsillar squamous cell carcinoma. 38
29749370 2018
22
Risk of contralateral nodal failure following ipsilateral IMRT for node-positive tonsillar cancer. 38
29224820 2017
23
Synchronous, bilateral tonsillar carcinomas: Patient characteristics and human papillomavirus genotypes. 38
29103737 2017
24
Metastatic tonsillar squamous cell carcinoma masquerading as a pancreatic cystic tumor and diagnosed by EUS-guided FNA. 38
28631390 2017
25
Comparison of the Clinical Outcomes of Patients with Squamous Cell Carcinoma of the Tonsil Receiving Postoperative Ipsilateral Versus Bilateral Neck Radiotherapy: A Propensity Score Matching Analysis (KROG 11-07). 38
28183163 2017
26
Endobronchial Metastasis from Extrapulmonary Neoplasms: Analysis of Clinicopathologic Features and Cytological Evaluation by Bronchial Brushing. 38
28555346 2017
27
Multimodality Treatment of Early-Stage Tonsil Cancer. 38
28669307 2017
28
Systemic matrix metalloproteinase-8 response in chronic tonsillitis. 38
27804311 2017
29
Human polyomavirus and human papillomavirus prevalence and viral load in non-malignant tonsillar tissue and tonsillar carcinoma. 38
27832373 2017
30
Cutaneous Metastasis From Tonsillar Squamous Cell Carcinoma: Report and Review of the Literature. 38
28465869 2017
31
Adjuvant radiation in the TORS era: Is there a benefit to omitting the tumor bed? 38
28274400 2017
32
HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma. 38
28607924 2017
33
Continuing rise in oropharyngeal cancer in a high HPV prevalence area: A Danish population-based study from 2011 to 2014. 38
27888679 2017
34
No evidence for the presence of Epstein-Barr virus in squamous cell carcinoma of the mobile tongue. 38
28926591 2017
35
Double positivity for HPV DNA/p16 in tonsillar and base of tongue cancer improves prognostication: Insights from a large population-based study. 38
27537425 2016
36
Minimal benefit of tonsillectomy in T1-T2 tonsillar squamous cell carcinoma treated with chemoradiotherapy. 38
27449724 2016
37
Radiotherapy alone or combined with chemotherapy as definitive treatment for squamous cell carcinoma of the tonsil. 38
27059836 2016
38
Tonsillar Squamous Cell Carcinoma: An Additional Consideration for Atypical Glossodynia. 38
28437054 2016
39
Evaluation of the factors contributing to long-term survival in canine tonsillar squamous cell carcinoma. 38
27237121 2016
40
In this issue - June 2016: High-quality care improves outcome in recumbent dairy cattle · Corneal anaesthesia in clinically normal cattle · Severe hyponatraemia in foals · Ultrasonographically visible hepatic location in clinically normal horses · Long-term survival in canine tonsillar squamous cell carcinoma · Treatment of oral squamous cell carcinoma in an inshore bottlenose dolphin · Alphaherpesvirus-associated disease in greater bilbies. 38
27237116 2016
41
Human papillomavirus in tonsillar squamous cell carcinomas from Guatemala and Brazil. 38
26972540 2016
42
Synchronous bilateral tonsillar squamous cell carcinoma related to human papillomavirus: Two case reports and a brief review of the literature. 38
27140027 2016
43
Histogram Analysis of Apparent Diffusion Coefficients for Occult Tonsil Cancer in Patients with Cervical Nodal Metastasis from an Unknown Primary Site at Presentation. 38
26115452 2016
44
Composition of inflammatory cells regulating the response to concurrent chemoradiation therapy for HPV (+) tonsil cancer. 38
26475063 2015
45
Molecular Pathogenesis of Human Papillomavirus Type 16 in Tonsillar Squamous Cell Carcinoma. 38
26637879 2015
46
Severe prolonged dysphagia following transoral resection of bilateral synchronous tonsillar carcinoma. 38
25663269 2015
47
Cell cannibalism by malignant neoplastic cells: three cases in dogs and a literature review. 38
25688652 2015
48
Carotid stent extrusion following carotid blowout. 38
25579083 2015
49
Prevalence and prognostic value of human papillomavirus genotypes in tonsillar squamous cell carcinoma: a Korean multicenter study. 38
25283642 2015
50
Reduced Expression of the Antigen Processing Machinery Components TAP2, LMP2, and LMP7 in Tonsillar and Base of Tongue Cancer and Implications for Clinical Outcome. 38
25749172 2015

Variations for Tonsil Squamous Cell Carcinoma

Cosmic variations for Tonsil Squamous Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6962642 upper aerodigestive tract,tonsil,carcinoma,squamous cell carcinoma c.935C>G p.S312C 19:10987741-10987741 0

Expression for Tonsil Squamous Cell Carcinoma

Search GEO for disease gene expression data for Tonsil Squamous Cell Carcinoma.

Pathways for Tonsil Squamous Cell Carcinoma

GO Terms for Tonsil Squamous Cell Carcinoma

Biological processes related to Tonsil Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to organic substance GO:0010033 9.16 TIMP2 CCND1
2 G1/S transition of mitotic cell cycle GO:0000082 8.96 CDKN2A CCND1
3 extracellular matrix disassembly GO:0022617 8.62 TIMP2 MMP13

Sources for Tonsil Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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