MCID: TNS005
MIFTS: 61

Tonsillitis

Categories: Immune diseases, Infectious diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Tonsillitis

MalaCards integrated aliases for Tonsillitis:

Name: Tonsillitis 12 55 43 44 15 63 73
Chronic Tonsillitis 12 55 73
Throat Infection - Tonsillitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10456
ICD10 33 J35.01 J35.0
ICD9CM 35 474.00
MeSH 44 D014069
NCIt 50 C116006
SNOMED-CT 68 90176007 90979004

Summaries for Tonsillitis

MedlinePlus : 43 What are tonsils? Tonsils are lumps of tissue at the back of the throat. There are two of them, one on each side. Along with the adenoids, tonsils are part of the lymphatic system. The lymphatic system clears away infection and keeps body fluids in balance. Tonsils and adenoids work by trapping the germs coming in through the mouth and nose. What is tonsillitis? Tonsillitis is an inflammation (swelling) of the tonsils. Sometimes along with tonsillitis, the adenoids are also swollen. What causes tonsillitis? The cause of tonsillitis is usually a viral infection. Bacterial infections such as strep throat can also cause tonsillitis. Who gets tonsillitis? Tonsillitis is most common in children over age two. Almost every child in the United States gets it at least once. Tonsillitis caused by bacteria is more common in kids ages 5-15. Tonsillitis caused by a virus is more common in younger children. Adults can get tonsillitis, but it is not very common. Is tonsillitis contagious? Although tonsillitis is not contagious, the viruses and bacteria that cause it are contagious. Frequent handwashing can help prevent spreading or catching the infections. What are the symptoms of tonsillitis? The symptoms of tonsillitis include A sore throat, which may be severe Red, swollen tonsils Trouble swallowing A white or yellow coating on the tonsils Swollen glands in the neck Fever Bad breath When should I get medical help for my child? You should call your health care provider if your child Has a sore throat for more than two days Has trouble or pain when swallowing Feels very sick or very weak You should get emergency care right away if your child Has trouble breathing Starts drooling Has a lot of trouble swallowing How is tonsillitis diagnosed? To diagnose tonsillitis, your child's health care provider will first ask you about your child's symptoms and medical history. The provider will look at your child's throat and neck, checking for things such as redness or white spots on the tonsils and swollen lymph nodes. Your child will probably also have one or more tests to check for strep throat, since it can cause tonsillitis and it requires treatment. It could be a rapid strep test, a throat culture, or both. For both tests, the provider uses a cotton swab to collect a sample of fluids from your child's tonsils and the back of the throat. With the rapid strep test, testing is done in the office, and you get the results within minutes. The throat culture is done in a lab, and it usually takes a few days to get the results. The throat culture is a more reliable test. So sometimes if the rapid strep test is negative (meaning that it does not show any strep bacteria), the provider will also do a throat culture just to make sure that your child does not have strep. What are the treatments for tonsillitis? Treatment for tonsillitis depends on the cause. If the cause is a virus, there is no medicine to treat it. If the cause is a bacterial infection, such as strep throat, your child will need to take antibiotics. It is important for your child to finish the antibiotics even if he or she feels better. If treatment stops too soon, some bacteria may survive and re-infect your child. No matter what is causing the tonsillitis, there are some things you can do to help your child feel better. Make sure that your child Gets a lot of rest Drinks plenty of fluids Tries eating soft foods if it hurts to swallow Tries eating warm liquids or cold foods like popsicles to soothe the throat Isn't around cigarette smoke or do anything else that could irritate the throat Sleeps in a room with a humidifier Gargles with saltwater Sucks on a lozenge (but do not give them to children under four; they can choke on them) Takes an over-the-counter pain reliever such as acetaminophen. Children and teenagers should not take aspirin. In some cases, your child may need a tonsillectomy. What is a tonsillectomy and why might my child need one? A tonsillectomy is surgery to remove the tonsils. Your child might need it if he or she Keeps getting tonsillitis Has bacterial tonsillitis that does not get better with antibiotics Has tonsils are too big, and are causing trouble breathing or swallowing Your child usually gets the surgery and goes home later that day. Very young children and people who have complications may need to stay in the hospital overnight. It can take a week or two before your child completely recovers from the surgery.

MalaCards based summary : Tonsillitis, also known as chronic tonsillitis, is related to rheumatic fever and sleep apnea, and has symptoms including sore throat An important gene associated with Tonsillitis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Cedax and Sufentanil have been mentioned in the context of this disorder. Affiliated tissues include tonsil, lymph node and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

PubMed Health : 63 About tonsillitis: Sore throats can have a range of causes. Common cold viruses are usually to blame. In rarer cases, sore throats are caused by an infection of the tonsils (tonsillitis). This infection is often bacterial, or sometimes viral. But it isn’t easy to tell what kind of germs are responsible for the infection. Children and teenagers are much more susceptible to tonsillitis than adults are.Acute tonsillitis starts suddenly and usually goes away again within one to two weeks. But tonsillitis can return several times over the course of a year and may become chronic. In chronic tonsillitis, the bacteria become permanently settled in the tonsils, which are always slightly inflamed as a result. People who have chronic tonsillitis might keep getting acute infections with more severe symptoms too. Having chronic tonsillitis can be a real problem, and may also lead to complications in rare cases.

Wikipedia : 76 Tonsillitis is inflammation of the tonsils, typically of rapid onset. It is a type of pharyngitis.... more...

Related Diseases for Tonsillitis

Diseases related to Tonsillitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 561)
# Related Disease Score Top Affiliating Genes
1 rheumatic fever 32.0 IL2 IL6 TNF
2 sleep apnea 31.5 TNF IL6 IL1B CXCL8
3 haemophilus influenzae 30.1 CXCL8 IL1B TNF
4 leukemia, chronic lymphocytic 29.9 IL1A IL2 IL4 TLR9
5 plasmacytoma 29.9 CD79A IL2 IL6
6 poliomyelitis 29.8 IFNG IL4 TNF
7 rhinitis 29.8 CXCL8 IL4 TLR9
8 laryngitis 29.8 IL1B IL6 TNF
9 glomerulonephritis 29.7 CD79A IL1B TLR9
10 rheumatic heart disease 29.7 IL4 IL6 TNF
11 lymphadenitis 29.6 TNF IL1B IFNG CXCL8
12 fasciitis 29.6 CXCL8 IL6 TNF
13 measles 29.6 IFNG IL2 IL4 IL6
14 hemophagocytic lymphohistiocytosis 29.5 CXCL8 IFNG TNF
15 gingival disease 29.5 IL1A IL1B IL6
16 septic arthritis 29.5 CXCL8 DEFB4A TLR9
17 arthritis 29.4 CXCL8 IFNG IL1A IL1B IL6 LTA
18 otitis media 29.4 CD79A CXCL8 IL1B IL4 IL6 TNF
19 necrotizing fasciitis 29.4 CXCL8 IL2 IL6 LTA
20 endocarditis 29.3 CXCL8 IL6 TNF
21 aphthous stomatitis 29.3 IL1B IL2 IL4 IL6 TNF
22 post-transplant lymphoproliferative disease 29.2 IL1A IL6 LTA TNF
23 pneumonia 29.1 CXCL8 IL1B IL6 TLR9 TNF
24 human immunodeficiency virus type 1 29.1 IFNG IL2 IL6 LTA TNF
25 purpura 29.1 CD79A IL6 TNF
26 human immunodeficiency virus infectious disease 29.1 IFNG IL2 IL6 TLR9 TNF
27 orofacial granulomatosis 29.1 CD79A IFNG IL4 TNF
28 osteoporosis 29.1 IFNG IL1A IL1B IL6 TNF
29 conjunctivitis 29.1 CXCL8 IFNG IL2 IL4 IL6
30 meningitis 29.0 CXCL8 IFNG IL1B IL6 TLR9 TNF
31 appendicitis 29.0 CXCL8 IL1B IL6 TNF
32 psoriatic arthritis 29.0 IL1A IL1B IL6 LTA TNF
33 bacterial meningitis 28.9 CXCL8 IL1B IL6 TLR9 TNF
34 rheumatoid arthritis 28.9 CXCL8 IFNG IL1A IL1B IL2 IL4
35 gastroenteritis 28.9 CXCL8 IL1B IL4 IL6 TNF
36 chlamydia 28.8 TNF IL6 IL4 IL1B IL1A IFNG
37 ulcerative colitis 28.8 CXCL8 IFNG IL1B IL2 IL6 TNF
38 dermatitis, atopic 28.7 CXCL8 DEFB4A IFNG IL2 IL4 TLR9
39 toxoplasmosis 28.7 TNF TLR9 IL6 IL4 IL1B IFNG
40 psoriasis 28.5 TNF TLR9 LTA IL6 IL4 IL2
41 colitis 28.5 TNF TLR9 IL6 IL4 IL2 IL1B
42 periodontitis 28.5 TNF TLR9 IL6 IL4 IL1B IL1A
43 gingivitis 28.5 TNF IL6 IL4 IL1B IL1A DEFB4A
44 toxic shock syndrome 28.4 TNF LTA IL6 IL4 IL2 IL1B
45 periodontal disease 28.4 CXCL8 DEFB1 DEFB4A IL1A IL1B IL6
46 leishmaniasis 28.3 TNF TLR9 IL6 IL4 IL2 IL1B
47 tonsil cancer 12.5
48 tonsil squamous cell carcinoma 12.4
49 tongue cancer 11.8
50 adenoid hypertrophy 11.6

Graphical network of the top 20 diseases related to Tonsillitis:



Diseases related to Tonsillitis

Symptoms & Phenotypes for Tonsillitis

UMLS symptoms related to Tonsillitis:


sore throat

GenomeRNAi Phenotypes related to Tonsillitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 CXCL8 IL1A IL1B IL2 LTA SOD1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 CXCL8 IL1A IL1B IL2 LTA SOD1

MGI Mouse Phenotypes related to Tonsillitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.14 CD79A IFNG IL1A IL1B IL2 IL4
2 homeostasis/metabolism MP:0005376 10.11 CD79A IFNG IL1A IL1B IL2 IL4
3 immune system MP:0005387 10.06 CD79A IFNG IL1A IL1B IL2 IL4
4 cardiovascular system MP:0005385 10.03 IFNG IL1A IL1B IL2 IL6 LTA
5 integument MP:0010771 9.8 IFNG IL1A IL1B IL4 IL6 SOD1
6 liver/biliary system MP:0005370 9.76 CD79A IFNG IL2 IL4 IL6 LTA
7 neoplasm MP:0002006 9.56 CD79A IFNG IL1A IL1B IL2 IL6
8 vision/eye MP:0005391 9.17 IFNG IL2 IL4 IL6 LTA SOD1

Drugs & Therapeutics for Tonsillitis

PubMedHealth treatment related to Tonsillitis: 63

The main goal of treatment is to relieve symptoms and prevent complications. The following medicines can be used to treat acute tonsillitis:Medication for relieving pain and lowering fever, like ibuprofen or acetaminophen (paracetamol)Antibiotics (for bacterial tonsillitis only)Antibiotics can make the tonsillitis go away a little sooner. They can also lower the risk of developing complications. But they have side effects too.Some people relieve their symptoms by sucking on throat lozenges, or using home remedies such as a neck wrap or gargling with salt water or tea.Recurrent tonsillitis can also be treated with painkillers or antibiotics. The surgical removal of tonsils is a treatment option for people who frequently get tonsillitis.

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Cedax 18 CEFTIBUTEN DIHYDRATE Schering-Plough December 1995

Drugs for Tonsillitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 203)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
2
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
3
Acetaminophen Approved Phase 4,Phase 2,Not Applicable 103-90-2 1983
4
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 447043
5
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 26787-78-0 33613
6
Penicillin V Approved, Vet_approved Phase 4,Phase 3,Not Applicable 87-08-1 6869
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2 1177-87-3
10
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
11
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
12
Codeine Approved, Illicit Phase 4 76-57-3 5284371
13
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
14
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
15
Clarithromycin Approved Phase 4,Phase 1 81103-11-9 84029
16
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
17
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
18
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
19
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
20
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
21
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
22
Racepinephrine Approved Phase 4 329-65-7 838
23
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
24
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
25
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
26
Ibuprofen Approved Phase 4 15687-27-1 3672
27
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
28 Tinoridine Investigational Phase 4 24237-54-5
29 Andrographolide Investigational Phase 4 5508-58-7
30
Propyl Gallate Investigational Phase 4 121-79-9 4947
31 Anesthetics, General Phase 4,Phase 2,Not Applicable
32 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
33 Analgesics, Opioid Phase 4,Phase 2,Not Applicable
34 Narcotics Phase 4,Phase 2,Not Applicable
35 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
36 Anesthetics, Intravenous Phase 4,Phase 2,Not Applicable
37 Adjuvants, Anesthesia Phase 4,Phase 2,Not Applicable
38 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
39 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
40 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Not Applicable
41 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Not Applicable
42 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Not Applicable
44 Anesthetics, Local Phase 4,Phase 3,Not Applicable
45 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
46 Fibrinolytic Agents Phase 4,Phase 3,Not Applicable
47 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Not Applicable
48 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Not Applicable
49 penicillins Phase 4,Phase 3,Not Applicable
50 BB 1101 Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 105)
# Name Status NCT ID Phase Drugs
1 Randomized Controlled Study of Plasmaknife Tonsillectomy Versus Monopolar Tonsillectomy Unknown status NCT00466544 Phase 4
2 Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Tonsillectomy or Adeno-tonsillectomy in Children Unknown status NCT02205580 Phase 4 continuous intravenous sufentanil 0.02μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.03μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.04μg•kg-1•h-1 infusion
3 Multicenter, Open, Randomized Comparative Trial To Compare The Efficacy Of Azithromycin Versus Amoxicillin In Children With Strep Throat Completed NCT00643539 Phase 4 Zithromax;Clamoxyl
4 Efficacy of Tinoridine in Treating Pain and Inflammation in Adults Completed NCT01224756 Phase 4 Tinoridine HCl;Placebo
5 Study of 5 and 10 Days Treatment With Penicillin Against Sore Throat Caused by Streptococci Completed NCT02712307 Phase 4 Phenoxymethylpenicillin
6 Dexmedetomidine for Immediate Perioperative Analgesia in Pediatric Patients Undergoing Tonsillectomy Completed NCT00654511 Phase 4 Fentanyl;Fentanyl;Dexmedetomidine;Dexmedetomidine
7 A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy Completed NCT01267136 Phase 4 Codeine with acetaminophen;Tramadol suspension
8 Acetaminophen's Efficacy For Post-operative Pain Completed NCT01721486 Phase 4 IV acetaminophen;PO acetaminophen
9 Recurrent Throat Infections and Tonsillectomy Completed NCT00547391 Phase 4
10 EXPAREL® for Pain After Tonsillectomy Completed NCT02444533 Phase 4 Liposomal Bupivacaine
11 Placebo and Active Controlled Study to Compare the Efficacy of Aspirin and Paracetamol in Treatment of Sore Throat Associated With a Common Cold Completed NCT01465009 Phase 4 Acetylsalicylic acid (Aspirin, BAYE4465);Paracetamol;Placebo
12 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
13 DIAMANTE - Diseases Infectious Analysis Microflora Antibiotic Effect Completed NCT00424905 Phase 4 Bacillus clausii
14 Clinical Trial for the Assessment of Delayed Antibiotic Treatment Strategies Completed NCT01363531 Phase 4
15 Evaluate the Efficacy and Safety of Andrographolide Sulfonate in Patients With Acute Tonsillitis Recruiting NCT03134443 Phase 4 Andrographolide sulfonate;Andrographolide sulfonate simulation
16 Perioperative Tonsillectomy Protocol Development Recruiting NCT03323047 Phase 4 Acetaminophen;Low-dose Dexamethasone;Placebo Oral Tablet;High-Dose Dexamethasone
17 Gabapentin Premedication to Reduce Postoperative Pain for Pediatric Tonsillectomy Recruiting NCT03625011 Phase 4 Gabapentin
18 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Recruiting NCT02162433 Phase 4 Normal Saline;Dexmedetomidine
19 Post-tonsillectomy Pain Control in Adults Recruiting NCT02358850 Phase 4 Norco (Hydrocodone and Acetaminophen);Percocet (Oxycodone and Acetaminophen);Dilaudid (hydromorphone);Tylenol (Acetaminophen)
20 EXPAREL Post-tonsillectomy Clinical Trial Recruiting NCT03420638 Phase 4 Adjunct Exparel (bupivacaine liposome suspension 1.3%)
21 Registration of the Study of Reyanning Mixture Not yet recruiting NCT03704506 Phase 4 Reyanning mixture;amoxil capsule;Reyanning mixture simulator;amoxil capsule simulator
22 the Effectiveness of Lactoferrin in Treatment of Iron Deficiency Anemia in Children With Chronic Tonsillitis Not yet recruiting NCT03748043 Phase 4 Lactoferrin;Ferric Hydroxide Polymaltose
23 Effect of OM-85 on Respiratory Tract Infections and Adenoid Tissue in Children With Adenoid Hypertrophy Not yet recruiting NCT03243565 Phase 4
24 Evaluation of Inflammatory Symptoms Reduction With Amoxicillin + Ketoprofen in Acute Pharyngeal Tonsillitis in Pediatric Patients Terminated NCT00799838 Phase 4 Ketoprofen;Placebo (for Ketoprofen);Amoxicillin
25 Post-operative Pain Control After Pediatric Adenotonsillectomy Terminated NCT02296840 Phase 4 Ibuprofen;Hydrocodone-Acetaminophen
26 Lactobacillus Reuteri DSM 17938 and Prevention of Respiratory and Gastrointestinal Infections in Mexican Infants Unknown status NCT01249911 Phase 3
27 Efficacy Study of Pristinamycin Versus Amoxicillin to Treat Tonsillitis Induced by Streptococcus in Children Completed NCT00393744 Phase 3 pristinamycin;amoxicillin
28 A Trial Of Azithromycin SR For The Treatment Of Laryngopharyngitis or Tonsillitis or Acute Bacterial Rhinosinusitis Completed NCT00393835 Phase 3 Azithromycin SR
29 A Multicenter, Randomized, Double-Blind, Double-Dummy Study Of Azithromycin SR Versus Amoxicillin For The Treatment Of Strep Throat In Children Completed NCT00643149 Phase 3 amoxicillin;azithromycin SR
30 A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial of Azithromycin Sustained Release Versus 3-Day Azithromycin for the Treatment of Strep Throat in Adolescents and Adults Completed NCT00644293 Phase 3 azithromycin (Zithromax);placebo;azithromycin SR;placebo
31 APC-111 Once a Day (QD) for 7 Days vs. Penicillin Taken Four Times a Day (QID) for 10 Days in Patients With Strep Throat Completed NCT00095368 Phase 3 Amoxicillin Pulsatile Release Multiparticulate Tablet (drug)
32 APC-111 MP Tablet Once a Day vs.Penicillin VK Four Times a Day Both for 10 Days in Patients With Strep Throat Completed NCT00242281 Phase 3 APC-111 MP Tablet, 775 mg
33 Active and Placebo Controlled Study to Test the Efficacy and Safety of an Aspirin-Lidocaine Lozenge in the Symptomatic Treatment of Sore Throat Associated With a Common Cold Completed NCT01361399 Phase 3 Acetylsalicylic acid (Aspirin, BAYE4465) & Lidocain;Acetylsalicylic Acid (Aspirin, BAYE4465);Lidocain;Placebo
34 A Long-Term Extension Study of RoActemra/Actemra (Tocilizumab) in Patients With Juvenile Idiopathic Arthritis From France Who Completed WA19977 Core Study Completed NCT01673919 Phase 3 tocilizumab [RoActemra/Actemra]
35 CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study Completed NCT01948856 Phase 3 J022X ST;Placebo
36 Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial Completed NCT01304927 Phase 2, Phase 3 Cholecalciferol and calcium
37 E. Coli Nissle 1917 - Suspension for Infection Prophylaxis Active, not recruiting NCT02802059 Phase 3 EcN-Suspension;Placebo
38 TELI TON - Telithromycin in Tonsillitis Terminated NCT00315042 Phase 3 Telithromycin (HMR3647);Penicillin
39 TELI TAD - Telithromycin in Tonsillitis in Adolescents and Adults Terminated NCT00315549 Phase 3 Telithromycin;Penicillin
40 Comparison of Floseal Hemostasis Tonsillectomy With Coblation Tonsillectomy and Cautery Hemostasis Tonsillectomy Withdrawn NCT00459927 Phase 2, Phase 3
41 Evaluation of Coblation Channeling in Treating Chronic Tonsillitis Unknown status NCT01193790 Phase 2
42 A Phase I/II to Assess Safety, Tolerability and Efficacy of DL-lactic Acid Syrup in Children With Recurrent Tonsillitis Completed NCT01988558 Phase 1, Phase 2 DL - Lactic Acid
43 Treatment of Acute Pharyngo-Tonsillitis With Essential Oils of Aromatic Plants Completed NCT00610519 Phase 1, Phase 2
44 Efficacy and Safety of Meloxicam vs. Naproxen Sodium in Patients With Acute Non Bacterial Pharyngitis or Pharyngo-tonsillitis Completed NCT02183038 Phase 2 Meloxicam low;Meloxicam high;Naproxen sodium;Meloxicam placebo low;Meloxicam placebo high;Naproxen sodium placebo
45 Celecoxib as a Post-tonsillectomy Pain Medication Completed NCT00583453 Phase 2 Celecoxib;Placebo
46 Analgesic Effect of IV Acetaminophen in Tonsillectomies Completed NCT01691690 Phase 2 Acetaminophen (paracetamol);Normal Saline Flush;Midazolam;Sevoflurane;Nitrous Oxide/Oxygen;Propofol;Morphine;Ondansetron;Dexamethasone
47 PASS Study To Evaluate The Potential Of Zithromax To Cause Ocular Problems In Pediatric Patients Terminated NCT01919996 Phase 2 Azithromycin
48 Evaluate Effects of Multiple Doses of Rifampin and Clarithromycin on the Single Dose Pharmacokinetics of Deflazacort Completed NCT02286635 Phase 1 Deflazacort and rifampin;Deflazacort and Clarithromycin
49 Controlled Human Infection for Vaccination Against Streptococcus Pyogenes Recruiting NCT03361163 Phase 1
50 Procalcitonin-guided Detection of Streptococcal Acute Tonsillitis Unknown status NCT01657968

Search NIH Clinical Center for Tonsillitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: tonsillitis

Genetic Tests for Tonsillitis

Anatomical Context for Tonsillitis

MalaCards organs/tissues related to Tonsillitis:

41
Tonsil, Lymph Node, Testes, Bone, Neutrophil, Heart, B Cells

Publications for Tonsillitis

Articles related to Tonsillitis:

(show top 50) (show all 854)
# Title Authors Year
1
Antibiotics for recurrent acute pharyngo-tonsillitis: systematic review. ( 29651614 )
2018
2
Use of Streptococcus salivarius K12 to reduce the incidence pharyngo-tonsillitis and acute otitis media in children: a retrospective analysis in not-recurrent pediatric subjects. ( 29322750 )
2018
3
Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis. ( 29942488 )
2018
4
Psoriasis, chronic tonsillitis, and biofilms: Tonsillar pathologic findings supporting a microbial hypothesis. ( 29554401 )
2018
5
Diagnostic role of mean platelet volume in tonsillitis with and without peritonsillar abscess. ( 29888695 )
2018
6
LipschA1tz ulcer and group A streptococcal tonsillitis. ( 29880620 )
2018
7
Is Scottish Intercollegiate Guidelines Network guidance for GP management of tonsillitis suitable? A qualitative study. ( 29590327 )
2018
8
Assessment of Volatile Sulfur Compounds in Adult and Pediatric Chronic Tonsillitis Patients Receiving Tonsillectomy. ( 29719951 )
2018
9
Detection of GSK-3I^ activation index in pediatric chronic tonsillitis is an indicator for chronic recurrent inflammation. ( 29530430 )
2018
10
A Taiwanese population-based study on the association between chronic tonsillitis and tonsil cancer. ( 29484140 )
2018
11
An Instrument for Rating Quality of Life Related to Sore Throat in Patients Suffering from Acute Pharyngitis or Tonsillitis. ( 30429687 )
2018
12
The Psoriasis Risk Allele HLA-C*06:02 Shows Evidence of Association with Chronic or Recurrent Streptococcal Tonsillitis. ( 30037793 )
2018
13
Association between Ca/Mg/P status and suppurative tonsillitis in children. ( 30043571 )
2018
14
DYNAMICS OF CONTENT OF SOME MINERALS IN TEENAGERS WITH CARDIOVASCULAR SYSTEM PATHOLOGY AGAINST THE BACKGROUND OF CHRONIC TONSILLITIS ZMIANY ZAWARTOŚCI NIEKTÓRYCH SKŁADNIKÓW MINERALNYCH U MŁODZIEŻY Z CHOROBAMI UKŁADU SERCOWO-NACZYNIOWEGO JAKO PODŁOŻE ROZWOJU PRZEWLEKŁEGO ZAPALENIA MIGDAŁKÓW PODNIEBIENNYCH. ( 30099424 )
2018
15
Assessing the Quality of the Management of Tonsillitis among Australian Children: A Population-Based Sample Survey. ( 30149777 )
2018
16
The bacterial community and local lymphocyte response are markedly different in patients with recurrent tonsillitis compared to obstructive sleep apnoea. ( 30174001 )
2018
17
Chronic tonsillitis and biofilms: a brief overview of treatment modalities. ( 30233227 )
2018
18
A Man With Tonsillitis and Hepatitis. ( 30265322 )
2018
19
Erratum: Chronic tonsillitis and biofilms: a brief overview of treatment modalities [Corrigendum]. ( 30319282 )
2018
20
THERMOSEMIOTICS OF ACUTE TONSILLITIS. ( 30358537 )
2018
21
Microbiological Profile of Chronic Tonsillitis in the Pediatric Age Group. ( 30473976 )
2018
22
A randomized, open-label, multicenter, comparative study of therapeutic efficacy, safety and tolerability of BNO 1030 extract, containing Althea root, Cammomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb in the treatment of acute non-bacterial tonsillitis in children aged 6 to 18 years. ( 30554882 )
2018
23
The differences in the expression of fractalkine and its receptor in conditions of tonsillar hypertrophy and chronic tonsillitis. ( 30554983 )
2018
24
Tonsillitis exacerbates renal injury in IgA nephropathy through promoting Th22 cells chemotaxis. ( 29549623 )
2018
25
Treatment Challenges of Group A Beta-hemolytic Streptococcal Pharyngo-Tonsillitis. ( 28680500 )
2017
26
Staphylococcus aureus isolated from tonsillectomized adult patients with recurrent tonsillitis. ( 27862322 )
2017
27
A white man with Kikuchi-Fujimoto disease mimicking lymphoma, preceded by frequent episodes of tonsillitis: a case report. ( 28189144 )
2017
28
Amoxicillin and clavulanate potassium in treating children with suppurative tonsillitis. ( 28952295 )
2017
29
Management of recurrent tonsillitis in children. ( 28385329 )
2017
30
Measles: A missed cause of acute tonsillitis. ( 29121387 )
2017
31
Correction: The carriage of interleukin-1B-31*C allele plus Staphylococcus aureus and Haemophilus influenzae increases the risk of recurrent tonsillitis in a Mexican population. ( 29023596 )
2017
32
The effect of tonsillectomy on the morbidity from recurrent tonsillitis. ( 28199053 )
2017
33
Inverse relationship between toxic shock syndrome toxin-1 antibodies and interferon-I^ and interleukin-6 in peripheral blood mononuclear cells from patients with pediatric tonsillitis caused by Staphylococcus aureus. ( 28483238 )
2017
34
The role of environmental tobacco exposure and Helicobacter pylori infection in the risk of chronic tonsillitis in children. ( 28380174 )
2017
35
The Impact of Tobacco Smoking Upon Chronic/Recurrent Tonsillitis and Post Tonsillectomy Bleeding. ( 28382125 )
2017
36
A Retrospective Cohort Study of Glossopharyngeal Nerve Taste in Children with Recurrent Acute Tonsillitis. ( 28045639 )
2017
37
Hyperplasia and the degree and activity of inflammation in chronic recurrent tonsillitis: a histopathological study. ( 28439693 )
2017
38
Helicobacter pylori in the tonsillar tissue: a possible association with chronic tonsillitis and laryngopharyngeal reflux. ( 28318453 )
2017
39
Immune thrombocytopenia of childhood responsive to tonsillectomy in the setting of chronic tonsillitis: A case report and literature review. ( 28648251 )
2017
40
Evidence Based Practice in Using Antibiotics for Acute Tonsillitis in Primary Care Practice. ( 28991775 )
2017
41
The carriage of interleukin-1B-31*C allele plus Staphylococcus aureus and Haemophilus influenzae increases the risk of recurrent tonsillitis in a Mexican population. ( 28542534 )
2017
42
Resolution of recurrent tonsillitis in a non-smoker who became a vaper. A case study and new hypothesis. ( 29150279 )
2017
43
Re: Implementation of an evidence-based acute tonsillitis protocol: our experience in one hundred and twenty-six patients. ( 28102937 )
2017
44
A Clinical Approach to Tonsillitis, Tonsillar Hypertrophy, and Peritonsillar and Retropharyngeal Abscesses. ( 28148705 )
2017
45
Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis. ( 28877231 )
2017
46
Distinct Distribution of Immunocytes in a Retropharyngeal Lymphadenopathy Associated with Kawasaki Disease: A Case Study Compared with Tonsillitis. ( 28467980 )
2017
47
Tonsillectomy or adenotonsillectomy versus non-surgical treatment for chronic/recurrent acute tonsillitis. ( 29479190 )
2017
48
Streptococcal tonsillitis related reactive arthritis - clinical, ultrasound imaging and immunohistochemical study. ( 29250657 )
2017
49
Effectiveness of an add-on treatment with the homeopathic medication SilAtro-5-90 in recurrent tonsillitis: An international, pragmatic, randomized, controlled clinical trial. ( 28779928 )
2017
50
A rare complication of tonsillitis: septic arthritis of the temporomandibular joint. ( 28461120 )
2017

Variations for Tonsillitis

Expression for Tonsillitis

Search GEO for disease gene expression data for Tonsillitis.

Pathways for Tonsillitis

Pathways related to Tonsillitis according to GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CD79A CXCL8 DEFB1 DEFB4A IFNG IL1A
2
Show member pathways
13.73 CXCL8 IFNG IL1A IL1B IL2 IL4
3
Show member pathways
13.62 CXCL8 IFNG IL1A IL1B IL2 IL4
4
Show member pathways
13.5 CXCL8 IL1A IL1B IL2 IL4 IL6
5
Show member pathways
13.47 CXCL8 IFNG IL1A IL1B IL2 IL4
6
Show member pathways
13.39 CXCL8 IL1A IL1B IL2 IL4 IL6
7
Show member pathways
13.32 CD79A IFNG IL1A IL1B IL2 IL4
8
Show member pathways
13.14 CXCL8 IFNG IL1B IL2 IL6 TLR10
9
Show member pathways
12.95 CXCL8 IFNG IL1A IL1B IL2 IL4
10 12.88 CXCL8 IFNG IL2 IL4 IL6
11
Show member pathways
12.83 IL2 IL4 IL6 LTA TNF
12
Show member pathways
12.82 CXCL8 IFNG IL1B IL6 TNF
13
Show member pathways
12.81 IL1A IL1B IL2 IL6 LTA TLR10
14
Show member pathways
12.75 IFNG IL1A IL1B LTA TNF
15
Show member pathways
12.74 IL1A IL1B LTA TLR10 TLR9 TNF
16
Show member pathways
12.73 IFNG IL1A IL1B IL2 IL4 IL6
17
Show member pathways
12.71 CXCL8 IFNG IL1A IL1B IL2 IL4
18
Show member pathways
12.7 CD79A IFNG IL2 IL4 TNF
19 12.7 CD79A IFNG IL1B IL2 IL4 TLR9
20
Show member pathways
12.67 IFNG IL1B IL2 IL6 TNF
21
Show member pathways
12.57 IFNG IL1A IL1B IL2 IL4 IL6
22
Show member pathways
12.55 IFNG IL2 IL4 TNF
23 12.47 IL2 IL6 LTA TNF
24
Show member pathways
12.47 CXCL8 IFNG IL1A IL1B IL6 TNF
25
Show member pathways
12.46 IFNG IL1B IL2 IL4 IL6 SOD1
26
Show member pathways
12.45 CXCL8 DEFB4A IFNG IL1B IL4 IL6
27
Show member pathways
12.43 IFNG IL2 IL4 IL6
28
Show member pathways
12.43 CXCL8 IL1A IL6 TLR10 TLR9 TNF
29
Show member pathways
12.39 IFNG IL1A IL1B IL4 TNF
30 12.38 IFNG IL1A IL1B IL6 TLR9 TNF
31
Show member pathways
12.37 CXCL8 IL1A IL1B IL6 TNF
32
Show member pathways
12.36 IL1B IL2 IL6 TLR9 TNF
33 12.33 IFNG IL6 TLR10 TLR9 TNF
34 12.33 CXCL8 IL1A IL1B IL6 TNF
35
Show member pathways
12.3 CXCL8 IFNG IL1A IL1B IL2 IL4
36
Show member pathways
12.29 IFNG IL1A IL1B TNF
37
Show member pathways
12.27 CXCL8 IL1A IL1B TLR10 TLR9
38
Show member pathways
12.22 CXCL8 IFNG IL1A IL1B IL2 IL4
39
Show member pathways
12.21 IFNG IL1B IL4 IL6 SOD1 TNF
40
Show member pathways
12.2 IL1A IL1B IL2 TLR10 TLR9
41 12.19 IFNG IL1A IL1B TNF
42
Show member pathways
12.19 CXCL8 DEFB4A IFNG IL1B IL4 IL6
43 12.15 IFNG IL1A IL1B TNF
44 12.15 CD79A IFNG IL2 IL4 IL6 TNF
45 12.13 CXCL8 IL1A IL1B IL4 IL6 TNF
46 12.12 CXCL8 IFNG IL1A IL1B IL6
47
Show member pathways
12.09 IFNG IL1B IL2 IL4
48 12.09 CXCL8 IL1A IL1B IL6 TNF
49 12.08 IL1B IL6 LTA TNF
50 12.07 IL1A IL1B IL4 IL6 TNF

GO Terms for Tonsillitis

Cellular components related to Tonsillitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 CXCL8 DEFB1 DEFB4A IFNG IL1A IL1B
2 extracellular region GO:0005576 9.44 CXCL8 DEFB1 DEFB4A IFNG IL1A IL1B

Biological processes related to Tonsillitis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.97 IFNG IL1B IL2 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.96 CXCL8 IL1B IL6 TNF
3 positive regulation of gene expression GO:0010628 9.95 IFNG IL1A IL1B IL4 IL6 TLR9
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 IL1B IL6 TLR9 TNF
5 defense response GO:0006952 9.92 CXCL8 DEFB1 DEFB4A TNF
6 inflammatory response GO:0006954 9.91 CXCL8 IL1A IL1B IL6 TLR10 TLR9
7 activation of MAPK activity GO:0000187 9.9 IL1B SOD1 TNF
8 response to ethanol GO:0045471 9.9 IL1B IL2 SOD1
9 positive regulation of DNA-binding transcription factor activity GO:0051091 9.9 IL1B IL6 TNF
10 positive regulation of JNK cascade GO:0046330 9.88 IL1B TLR9 TNF
11 regulation of insulin secretion GO:0050796 9.87 IFNG IL1B TNF
12 defense response to Gram-negative bacterium GO:0050829 9.87 DEFB1 DEFB4A IL6 TLR9
13 response to glucocorticoid GO:0051384 9.86 IL1B IL6 TNF
14 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.86 CXCL8 DEFB1 DEFB4A
15 positive regulation of inflammatory response GO:0050729 9.86 IL2 TLR10 TLR9 TNF
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 IL1B TLR9 TNF
17 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 IFNG IL2 IL4 IL6
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IFNG IL1B TNF
19 positive regulation of T cell proliferation GO:0042102 9.83 IL1B IL2 IL4 IL6
20 defense response to Gram-positive bacterium GO:0050830 9.83 DEFB1 DEFB4A IL6 LTA TNF
21 positive regulation of JUN kinase activity GO:0043507 9.82 IL1B TLR9 TNF
22 positive regulation of B cell proliferation GO:0030890 9.82 IL2 IL4 TLR9
23 positive regulation of interleukin-6 production GO:0032755 9.81 IL1B IL6 TLR9 TNF
24 humoral immune response GO:0006959 9.8 IFNG IL6 LTA TNF
25 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.79 IL1A IL1B TNF
26 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.79 IL1A IL1B IL2
27 positive regulation of interferon-gamma production GO:0032729 9.78 IL1B IL2 LTA TNF
28 positive regulation of interleukin-8 production GO:0032757 9.77 IL1B TLR9 TNF
29 negative regulation of neurogenesis GO:0050768 9.76 IL1B IL6 TNF
30 positive regulation of chemokine production GO:0032722 9.75 IL6 TLR9 TNF
31 embryonic digestive tract development GO:0048566 9.74 CXCL8 TNF
32 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
33 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.73 IL1B TNF
34 response to copper ion GO:0046688 9.73 IL1A SOD1
35 regulation of regulatory T cell differentiation GO:0045589 9.72 IFNG IL2
36 negative regulation of growth of symbiont in host GO:0044130 9.72 LTA TNF
37 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL1B TNF
38 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.72 IL1A IL1B
39 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IFNG IL1B TNF
40 regulation of cytokine secretion GO:0050707 9.71 TLR10 TLR9
41 positive regulation of immunoglobulin secretion GO:0051024 9.71 IL2 IL6
42 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 TLR9
43 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.71 IL1B TLR9
44 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.71 TLR9 TNF
45 positive regulation of isotype switching to IgG isotypes GO:0048304 9.7 IL2 IL4
46 negative regulation of lipid storage GO:0010888 9.7 IL6 TNF
47 cytokine-mediated signaling pathway GO:0019221 9.7 CXCL8 IL1A IL1B IL2 IL4 IL6
48 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
49 ectopic germ cell programmed cell death GO:0035234 9.68 IL1A IL1B
50 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF

Molecular functions related to Tonsillitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CXCL8 IFNG IL1A IL1B IL2 IL4
2 CCR6 chemokine receptor binding GO:0031731 9.16 DEFB1 DEFB4A
3 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B TLR9

Sources for Tonsillitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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