Categories: Immune diseases, Infectious diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Tonsillitis

MalaCards integrated aliases for Tonsillitis:

Name: Tonsillitis 12 54 42 43 15 62 71
Chronic Tonsillitis 12 54 71 32
Throat Infection - Tonsillitis 12


External Ids:

Disease Ontology 12 DOID:10456
ICD9CM 34 474.00
MeSH 43 D014069
NCIt 49 C116006
SNOMED-CT 67 90176007 90979004
ICD10 32 J35.0 J35.01
UMLS 71 C0040425 C0149517

Summaries for Tonsillitis

MedlinePlus : 42 What are tonsils? Tonsils are lumps of tissue at the back of the throat. There are two of them, one on each side. Along with the adenoids, tonsils are part of the lymphatic system. The lymphatic system clears away infection and keeps body fluids in balance. Tonsils and adenoids work by trapping the germs coming in through the mouth and nose. What is tonsillitis? Tonsillitis is an inflammation (swelling) of the tonsils. Sometimes along with tonsillitis, the adenoids are also swollen. What causes tonsillitis? The cause of tonsillitis is usually a viral infection. Bacterial infections such as strep throat can also cause tonsillitis. Who is at risk for tonsillitis? Tonsillitis is most common in children over age two. Almost every child in the United States gets it at least once. Tonsillitis caused by bacteria is more common in kids ages 5-15. Tonsillitis caused by a virus is more common in younger children. Adults can get tonsillitis, but it is not very common. Is tonsillitis contagious? Although tonsillitis is not contagious, the viruses and bacteria that cause it are contagious. Frequent handwashing can help prevent spreading or catching the infections. What are the symptoms of tonsillitis? The symptoms of tonsillitis include A sore throat, which may be severe Red, swollen tonsils Trouble swallowing A white or yellow coating on the tonsils Swollen glands in the neck Fever Bad breath When should I get medical help for my child? You should call your health care provider if your child Has a sore throat for more than two days Has trouble or pain when swallowing Feels very sick or very weak You should get emergency care right away if your child Has trouble breathing Starts drooling Has a lot of trouble swallowing How is tonsillitis diagnosed? To diagnose tonsillitis, your child's health care provider will first ask you about your child's symptoms and medical history. The provider will look at your child's throat and neck, checking for things such as redness or white spots on the tonsils and swollen lymph nodes. Your child will probably also have one or more tests to check for strep throat, since it can cause tonsillitis and it requires treatment. It could be a rapid strep test, a throat culture, or both. For both tests, the provider uses a cotton swab to collect a sample of fluids from your child's tonsils and the back of the throat. With the rapid strep test, testing is done in the office, and you get the results within minutes. The throat culture is done in a lab, and it usually takes a few days to get the results. The throat culture is a more reliable test. So sometimes if the rapid strep test is negative (meaning that it does not show any strep bacteria), the provider will also do a throat culture just to make sure that your child does not have strep. What are the treatments for tonsillitis? Treatment for tonsillitis depends on the cause. If the cause is a virus, there is no medicine to treat it. If the cause is a bacterial infection, such as strep throat, your child will need to take antibiotics. It is important for your child to finish the antibiotics even if he or she feels better. If treatment stops too soon, some bacteria may survive and re-infect your child. No matter what is causing the tonsillitis, there are some things you can do to help your child feel better. Make sure that your child Gets a lot of rest Drinks plenty of fluids Tries eating soft foods if it hurts to swallow Tries eating warm liquids or cold foods like popsicles to soothe the throat Isn't around cigarette smoke or do anything else that could irritate the throat Sleeps in a room with a humidifier Gargles with saltwater Sucks on a lozenge (but do not give them to children under four; they can choke on them) Takes an over-the-counter pain reliever such as acetaminophen. Children and teenagers should not take aspirin. In some cases, your child may need a tonsillectomy. What is a tonsillectomy and why might my child need one? A tonsillectomy is surgery to remove the tonsils. Your child might need it if he or she Keeps getting tonsillitis Has bacterial tonsillitis that does not get better with antibiotics Has tonsils are too big, and are causing trouble breathing or swallowing Your child usually gets the surgery and goes home later that day. Very young children and people who have complications may need to stay in the hospital overnight. It can take a week or two before your child completely recovers from the surgery.

MalaCards based summary : Tonsillitis, also known as chronic tonsillitis, is related to diphtheria and pharyngitis, and has symptoms including sore throat An important gene associated with Tonsillitis is DEFB1 (Defensin Beta 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Hydromorphone and Sufentanil have been mentioned in the context of this disorder. Affiliated tissues include tonsil, testes and b cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 An upper respiratory tract disease which is characterized by inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat, painful or difficult swallowing, coughing, headache, myalgia, fever and chills.

PubMed Health : 62 About tonsillitis: Sore throats can have a range of causes. Common cold viruses are usually to blame. In rarer cases, sore throats are caused by an infection of the tonsils (tonsillitis). This infection is often bacterial, or sometimes viral. But it isn’t easy to tell what kind of germs are responsible for the infection. Children and teenagers are much more susceptible to tonsillitis than adults are. Acute tonsillitis starts suddenly and usually goes away again within one to two weeks. But tonsillitis can return several times over the course of a year and may become chronic. In chronic tonsillitis, the bacteria become permanently settled in the tonsils, which are always slightly inflamed as a result. People who have chronic tonsillitis might keep getting acute infections with more severe symptoms too. Having chronic tonsillitis can be a real problem, and may also lead to complications in rare cases.

Wikipedia : 74 Tonsillitis is inflammation of the tonsils, typically of rapid onset. It is a type of pharyngitis.... more...

Related Diseases for Tonsillitis

Diseases related to Tonsillitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1047)
# Related Disease Score Top Affiliating Genes
1 diphtheria 32.6 TNF IL4 IL2 IFNG
2 pharyngitis 32.3 TNF LACTB IL6 IL1B CXCL8
3 sleep apnea 32.3 TNF IL6 IL1B IL10 CXCL8
4 rheumatic fever 32.2 TNF IL6 IL2 IL1A IL10 IFNG
5 plague 32.1 TNF TLR9 TLR4 IL6 IL10
6 haemophilus influenzae 31.3 TNF LACTB CXCL8
7 rheumatic disease 31.3 TNF IL1B IL10 IFNG
8 poliomyelitis 30.7 TNF IL4 IL10 IFNG
9 apnea, obstructive sleep 30.7 TNF IL6 CXCL8
10 mycobacterium tuberculosis 1 30.6 TNF TLR9 TLR4 IL4 IL10 IFNG
11 allergic rhinitis 30.6 IL4 IL10 IFNG CXCL8
12 ige responsiveness, atopic 30.5 IL4 IL10 IFNG
13 exanthem 30.4 TNF IL6 IL2 IL10 CXCL8
14 cellulitis 30.4 TNF IL6 IL10
15 penicillin allergy 30.4 LACTB IL4 IL10 IFNG
16 burkitt lymphoma 30.3 TNF TLR9 IL6 IL4 IL10
17 helicobacter pylori infection 30.3 IL1B CXCL8 CXCL1
18 plasmacytoma 30.3 IL6 IL4 IL2 CD79A
19 b-cell growth factor 30.3 IL6 IL4 IFNG
20 erysipelas 30.3 TNF SOD1 IL6 IL2
21 rhinitis 30.2 TNF IL6 IL4 IL10 IFNG CXCL8
22 sarcoidosis 1 30.2 TNF LTA IL2 IL1B IL1A IFNG
23 post-transplant lymphoproliferative disease 30.2 TNF LTA IL6 IL1A IL10
24 alopecia 30.2 TNF IL4 IL2 IFNG
25 campylobacteriosis 30.2 TLR4 IL1B IFNG
26 rheumatic heart disease 30.2 TNF IL6 IL4 IL1B IL10
27 necrotizing fasciitis 30.2 LTA IL6 IL2 CXCL8
28 laryngitis 30.1 TNF IL6 IL1B IL1A
29 fasciitis 30.1 TNF IL6 IL2 IFNG CXCL8
30 extrapulmonary tuberculosis 30.1 TNF IL1B IL10 IFNG
31 graves' disease 30.1 LTA IL4 IL1A IFNG
32 hypereosinophilic syndrome 30.1 IL4 IL2 IL10 IFNG CXCL8
33 pulmonary tuberculosis 30.0 TNF TLR4 IL6 IL4 IL2 IL10
34 severe combined immunodeficiency 30.0 IL6 IL4 IL2 IL10 IFNG
35 kaposi sarcoma 30.0 TLR3 IL6 CXCL8 CXCL1
36 lymphopenia 30.0 IL6 IL4 IL2 IL10 IFNG
37 lymphadenitis 30.0 TNF TLR4 IL1B IL10 IFNG CXCL8
38 pulmonary sarcoidosis 30.0 TNF IL2 IFNG
39 diffuse large b-cell lymphoma 29.9 TNF IL6 IL10 CD79A
40 acute myocarditis 29.9 TLR3 IL6 IL10
41 central nervous system lymphoma 29.9 IL6 IL2 IL10
42 herpes zoster 29.9 TNF IL2 IL10 IFNG
43 septic arthritis 29.9 TLR9 TLR4 TLR3 IFNG CXCL8
44 endocarditis 29.9 TNF LACTB IL6 IL10 IFNG CXCL8
45 subacute thyroiditis 29.9 TNF IL6 IL1B
46 thyroiditis 29.8 TNF IL6 IL4 IL2 IL10
47 tularemia 29.8 TNF TLR4 IL6
48 neuromuscular disease 29.8 TNF SOD1 IL6 IL2 IL10
49 cyclic neutropenia 29.8 TNF IL1B IFNG CXCL8
50 hemophagocytic lymphohistiocytosis 29.8 TNF IL10 IFNG CXCL8

Graphical network of the top 20 diseases related to Tonsillitis:

Diseases related to Tonsillitis

Symptoms & Phenotypes for Tonsillitis

UMLS symptoms related to Tonsillitis:

sore throat

GenomeRNAi Phenotypes related to Tonsillitis according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.83 CXCL8 IL10 IL1A IL1B IL2 LTA
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.83 CXCL8 IL10 IL1A IL1B IL2 LTA

MGI Mouse Phenotypes related to Tonsillitis:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 CD79A CXCL6 IFNG IL10 IL1A IL1B
2 hematopoietic system MP:0005397 10.35 CD79A CXCL6 IFNG IL10 IL1A IL1B
3 immune system MP:0005387 10.31 CD79A CXCL6 IFNG IL10 IL1A IL1B
4 cardiovascular system MP:0005385 10.29 IFNG IL10 IL1A IL1B IL2 IL6
5 mortality/aging MP:0010768 10.17 CD79A CXCL6 IFNG IL10 IL1B IL2
6 digestive/alimentary MP:0005381 10.1 IFNG IL10 IL2 IL4 IL6 TLR4
7 liver/biliary system MP:0005370 10.07 CD79A IFNG IL10 IL2 IL4 IL6
8 integument MP:0010771 10.06 IFNG IL10 IL1A IL1B IL4 IL6
9 neoplasm MP:0002006 10 CD79A IFNG IL10 IL1A IL1B IL2
10 nervous system MP:0003631 9.9 CD79A IFNG IL10 IL1B IL4 IL6
11 respiratory system MP:0005388 9.61 IFNG IL10 IL2 IL4 IL6 LTA
12 vision/eye MP:0005391 9.32 IFNG IL10 IL2 IL4 IL6 LACTB

Drugs & Therapeutics for Tonsillitis

PubMed Health treatment related to Tonsillitis: 62

The main goal of treatment is to relieve symptoms and prevent complications. The following medicines can be used to treat acute tonsillitis : Medication for relieving pain and lowering fever , like ibuprofen or acetaminophen (paracetamol) Antibiotics (for bacterial tonsillitis only) Antibiotics can make the tonsillitis go away a little sooner. They can also lower the risk of developing complications. But they have side effects too. Some people relieve their symptoms by sucking on throat lozenges, or using home remedies such as a neck wrap or gargling with salt water or tea. Recurrent tonsillitis can also be treated with painkillers or antibiotics . The surgical removal of tonsils is a treatment option for people who frequently get tonsillitis.

Drugs for Tonsillitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 213)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
Oseltamivir Approved Phase 4 196618-13-0, 204255-11-8 65028
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
Azithromycin Approved Phase 4 83905-01-5 55185 447043
Clarithromycin Approved Phase 4 81103-11-9 84029
Codeine Approved, Illicit Phase 4 76-57-3 5284371
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560 441411
Lumefantrine Approved Phase 4 82186-77-4 6437380
Artemether Approved Phase 4 71963-77-4 119380 68911
Artesunate Approved, Investigational Phase 4 88495-63-0 6917864 5464098
Amodiaquine Approved, Investigational Phase 4 86-42-0 2165
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 23925 27284
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Ondansetron Approved Phase 4 99614-02-5 4595
Morphine Approved, Investigational Phase 4 57-27-2 5288826
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
Racepinephrine Approved Phase 4 329-65-7 838
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
Glutamic acid Approved, Nutraceutical Phase 4 56-86-0 33032
36 Andrographolide Investigational Phase 4 5508-58-7
Propyl Gallate Investigational Phase 4 121-79-9 4947
38 Tinoridine Investigational Phase 4 24237-54-5
Lactitol Investigational Phase 4 585-86-4, 585-88-6 493591
40 Andrographis Phase 4
41 Antioxidants Phase 4
42 Protective Agents Phase 4
43 Broncho-Vaxom Phase 4
44 Adjuvants, Anesthesia Phase 4
45 Platelet Aggregation Inhibitors Phase 4
46 Antiparasitic Agents Phase 4
47 Antiviral Agents Phase 4
48 Antiprotozoal Agents Phase 4
49 Anesthetics, General Phase 4
50 Anesthetics, Intravenous Phase 4

Interventional clinical trials:

(show top 50) (show all 119)
# Name Status NCT ID Phase Drugs
1 Randomized Controlled Study of Plasmaknife Tonsillectomy Versus Monopolar Tonsillectomy Unknown status NCT00466544 Phase 4
2 Post-tonsillectomy Pain Control in Adults: a Randomized Prospective Study Unknown status NCT02358850 Phase 4 Norco (Hydrocodone and Acetaminophen);Percocet (Oxycodone and Acetaminophen);Dilaudid (hydromorphone);Tylenol (Acetaminophen)
3 Combined With Andrographolide Sulfonate on the Basis of Conventional Therapy in the Treatment of Acute Tonsillitis: a Randomized, Single Blind, Placebo-controlled, Multicenter Study Unknown status NCT03134443 Phase 4 Andrographolide sulfonate;Andrographolide sulfonate simulation
4 Comparison of Three Different Rates of Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Coblation Tonsillectomy or Adeno-tonsillectomy in Children Unknown status NCT02205580 Phase 4 continuous intravenous sufentanil 0.02μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.03μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.04μg•kg-1•h-1 infusion
5 Banlangen Granules Anti-seasonal Influenza Study: a Randomized, Double Blind, Positive and Placebo Controlled,Clinical Study. Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
6 Effect of Vaxoral® (OM-85) on Frequency of Respiratory Tract Infections and Size of Adenoid Tissue in Preschool Children With Adenoid Hypertrophy Unknown status NCT03243565 Phase 4
7 Safety and Efficacy of Tinoridine in the Treatment of Pain and Inflammation in Patients With Acute Tonsillitis and/or Acute Pharyngitis: a Randomized, Double-blind Study Versus Placebo Completed NCT01224756 Phase 4 Tinoridine HCl;Placebo
8 Dexmedetomidine for Immediate Perioperative Analgesia in Pediatric Patients Undergoing Tonsillectomy. Completed NCT00654511 Phase 4 Fentanyl;Fentanyl;Dexmedetomidine;Dexmedetomidine
9 Multicenter, Open, Randomized Comparative Trial To Compare Bacteriological And Clinical Efficacy Of Azithromycin Versus Amoxicillin In Children With Streptococcus Tonsillitis Completed NCT00643539 Phase 4 Zithromax;Clamoxyl
10 Efficacy of IV vs Oral Administration of Acetaminophen for Pain Control Following Tonsillectomy With or Without Adenoidectomy Completed NCT01721486 Phase 4 IV acetaminophen;PO acetaminophen
11 A Randomized Controlled Study of 5 and 10 Days Treatment With Phenoxymethylpenicillin for Pharyngotonsillitis Caused by Streptococcus Group A Completed NCT02712307 Phase 4 Phenoxymethylpenicillin
12 Evaluation of the Effects of Enterogermina, 2 Billion Bacillus Clausii Spores, on the Intestinal Flora of Children Antibiotic Treated for Bacterial Upper Respiratory Tract Infections: Open, Pilot Study. Completed NCT00424905 Phase 4 Bacillus clausii
13 Recurrent Throat Infections and Tonsillectomy Completed NCT00547391 Phase 4
14 Clinical Trial for the Assessment of Delayed Antibiotic Treatment Strategies in the Non-complicated Acute Respiratory Tract Infections in General Practice Completed NCT01363531 Phase 4
15 A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy Completed NCT01267136 Phase 4 Codeine with acetaminophen;Tramadol suspension
16 Double-blind, Randomized, Placebo-controlled, Single Dose, Parallel Group Study Evaluating Efficacy and Safety of 1000 mg Acetylsalicylic Acid and 1000 mg Paracetamol in Adult Patients With Sore Throat Associated With a Common Cold Completed NCT01465009 Phase 4 Acetylsalicylic acid (Aspirin, BAYE4465);Paracetamol;Placebo
17 A Phase IV Randomize, Single-Blind, Trial of Liposomal Bupivacaine (EXPAREL®) for Pain Control in Post-Tonsillectomy Patients Completed NCT02444533 Phase 4 Liposomal Bupivacaine
18 Comparison of Azithromycin or Clarithromycin in 3drugs Protocol of H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
19 In Vivo Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for the Treatment of Uncomplicated Falciparum Malaria: an Open-randomised, Non-inferiority Clinical Trial in South Kivu, DR Congo Completed NCT02741024 Phase 4 Amodiaquine-Artesunate (ASAQ);Artemether-Lumefantrine (AL)
20 the Effectiveness of Lactoferrin in Treatment of Iron Deficiency Anemia in Children With Chronic Tonsillitis Recruiting NCT03748043 Phase 4 Lactoferrin;Ferric Hydroxide Polymaltose
21 Bizact Versus Electroscissor for Adult Tonsillectomy Recruiting NCT03854279 Phase 4
22 Gabapentin Premedication to Reduce Postoperative Pain for Pediatric Tonsillectomy/Adenoidectomy: Randomized Control Trial Recruiting NCT03625011 Phase 4 Gabapentin
23 Ketorolac as a Strategy for Reducing Post-operative Opioid Requirements in Children With Obstructive Sleep Apnea Undergoing Adenotonsillectomy: a Randomized Controlled Trial Recruiting NCT03467750 Phase 4 Ketorolac;Standard of Care
24 Perioperative Tonsillectomy Protocol Development for Preoperative Acetaminophen and Intraoperative High Dose Dexamethasone: a Randomized Control Trial Recruiting NCT03323047 Phase 4 Acetaminophen;Low-dose Dexamethasone;Placebo Oral Tablet;High-Dose Dexamethasone
25 Randomized Clinical Trial Examining Use of Adjunct EXPAREL for Post-tonsillectomy Pain Management in Adults Active, not recruiting NCT03420638 Phase 4 Adjunct Exparel (bupivacaine liposome suspension 1.3%)
26 A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Trial of the Efficacy and Safety of Treating Acute Tonsillitis With Reyanning Mixture Alone/in Combination With Antibiotics. Not yet recruiting NCT03704506 Phase 4 Reyanning mixture;amoxil capsule;Reyanning mixture simulator;amoxil capsule simulator
27 A Randomized Controlled Clinical Trial of Streptococcus Group A-negative Acute Tonsillitis in Primary Health Care - a Comparison of Phenoxymethylpenicillin and no Antibiotic Treatment Not yet recruiting NCT04083417 Phase 4 Phenoxymethylpenicillin
28 A Comparison of Postoperative Tramadol/Gabapentin/Ibuprofen Versus Tramadol/Placebo/Ibuprofen in Children Undergoing Tonsillectomy Terminated NCT02076893 Phase 4 gabapentin;Tramadol;Ibuprofen;Placebo
29 Randomized Non Inferiority Study Comparing Short Course of Oral Amoxicillin to One of the Usual Treatments of Lower Leg Erysipelas Terminated NCT01059123 Phase 4 Amoxicillin;Amoxicillin
30 Does Dexmedetomidine Decrease the Incidence of Untoward Airway Events After Deep or Awake Extubation in Patients Undergoing Adenotonsillectomy With or Without Myringotomy and Tube Placement? Terminated NCT02162433 Phase 4 Normal Saline;Dexmedetomidine
31 Comparing Narcotics With Non-steroidal Anti-inflammatory Drugs (NSAIDS) Post-operatively in Pediatric Patients Undergoing Adenotonsillectomy Terminated NCT02296840 Phase 4 Ibuprofen;Hydrocodone-Acetaminophen
32 T Cell and Interferon Expression in Tonsils After Sublingual Immunotherapy and/or Nasal Live Attenuated Influenza Vaccine Unknown status NCT01924208 Phase 3
33 A Multicenter, Non-Randomized, Open Label Trial Of Azithromycin Sustained Release (SR) For The Treatment Of Laryngopharyngitis or Tonsillitis or Acute Bacterial Rhinosinusitis In Japan Adults Completed NCT00393835 Phase 3 Azithromycin SR
34 A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial Of Azithromycin SR Versus Amoxicillin For The Treatment Of Group A Β-Hemolytic Streptococcal Pharyngitis/Tonsillitis In Children Completed NCT00643149 Phase 3 amoxicillin;azithromycin SR
35 A Phase III, Randomized, Double-Blind, Double-Dummy Multicenter Study to Evaluate the Efficacy and Safety of 775 mg APC-111 MP Tablet QD for 7 Days vs Penicillin VK 250 mg QID for 10 Days in Patients With Streptococcus Pyogenes Completed NCT00095368 Phase 3 Amoxicillin Pulsatile Release Multiparticulate Tablet (drug)
36 A Phase III, Open, Randomised, Multicentre Study Comparing the Efficacy and Safety of Pristinamycin, at Dosages of 50 mg/kg/d in 2 Doses for Children, and 1g Twice Daily in Adults for 4 Days Versus Amoxicillin at a Dosage of 50 mg/kg/d in 2 Doses in Children and 1 g Twice Daily in Adults for 6 Days, Consumed Orally, in the Treatment of Tonsillitis Induced by Group-A Beta-Haemolytic Streptococcus in Patients Aged Between 6 and 25 Years. Completed NCT00393744 Phase 3 pristinamycin;amoxicillin
37 A Phase III, Multicenter Study to Evaluate the Safety/Efficacy of APC-111 MP Tablet QD vs. Penicillin VK QID Both for 10 Days Treatment of Pharyngitis Secondary to S.Pyogenes in Adolescents/Adults Completed NCT00242281 Phase 3 APC-111 MP Tablet, 775 mg
38 A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial of Azithromycin SR Versus Three-Day Azithromycin for the Treatment of Group A β-Hemolytic Streptococcal Pharyngitis/Tonsillitis in Adolescents and Adults Completed NCT00644293 Phase 3 azithromycin (Zithromax);placebo;azithromycin SR;placebo
39 Comparison of Treatment Satisfaction and Treatment Adherence of a Novel Application Form "Dose Sipping Technology" (DST) of Oral Clarithromycin vs. Clarithromycin Syrup in Children Suffering From Acute Otitis Media, Tonsillitis, Pharyngitis, or Acute Bacterial Bronchitis (DoSe iT) Completed NCT04016051 Phase 3 Clarithromycin DST (125 mg);Clarithromycin DST (187.5 mg);Clarithromycin DST (250 mg);Clarithromycin Syrup (125 mg);Clarithromycin Syrup (187.5 mg);Clarithromycin Syrup (250 mg)
40 CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study Completed NCT01948856 Phase 3 J022X ST;Placebo
41 A 4-arm, Multicenter, Randomized, Double-blind, Placebo- and Active-controlled, Single Dose, Parallel Group Study Comparing Efficacy and Safety of a Fixed Combination of 500 mg Acetylsalicylic Acid + 4 mg Lidocaine With 500 mg Acetylsalicylic Acid and 4 mg Lidocaine Monotherapy as Well as Placebo in Adult Patients With Sore Throat Associated With a Common Cold. Completed NCT01361399 Phase 3 Acetylsalicylic acid (Aspirin, BAYE4465) & Lidocain;Acetylsalicylic Acid (Aspirin, BAYE4465);Lidocain;Placebo
42 Multinational, Randomized, Double Blind, Comparative Study to Evaluate the Efficacy and Safety of 5 Days Telithromycin 800 mg od Versus 10 Days Penicillin V 500 mg Tid in Adolescent and Adult Subjects Equal to or Over 13 Years With Streptococcus Pyogenes Tonsillitis/Pharyngitis Terminated NCT00315549 Phase 3 Telithromycin;Penicillin
43 Multinational, Randomized, Double-Blind, Double Dummy, Comparative Study to Evaluate the Efficacy and Safety of 5 Days Telithromycin 25mg/kg od Versus 10 Days Penicillin V 13.3 mg/kg Tid in Children 6 Months to Less Than 13 Years With Streptococcus Pyogenes Tonsillitis/Pharyngitis Terminated NCT00315042 Phase 3 Telithromycin (HMR3647);Penicillin
44 Prospective, Controlled Clinical Trial of a Novel Hemostatic Sealant Versus Electrocautery Hemostasis and Coblation Dissection in Patients Undergoing Tonsillectomy Withdrawn NCT00459927 Phase 2, Phase 3
45 Evaluation of Coblation Channeling in Treating Chronic Tonsillitis Unknown status NCT01193790 Phase 2
46 A Phase I/II, Randomized, Double Blind, Placebo-controlled Study to Assess the Safety, Tolerability and Efficacy of DL-lactic Acid Syrup (Tonsitin) in Children With Recurrent Tonsillitis. Completed NCT01988558 Phase 1, Phase 2 DL - Lactic Acid
47 Double-blind Study to Compare Efficacy and Safety of Meloxicam 7.5 mg and 15 mg vs. Naproxen Sodium 1100 mg in the Symptomatic Treatment of Acute Non Bacterial Pharyngitis or Pharyngo-tonsillitis Over a Period of 5 Days Completed NCT02183038 Phase 2 Meloxicam low;Meloxicam high;Naproxen sodium;Meloxicam placebo low;Meloxicam placebo high;Naproxen sodium placebo
48 Treatment of Acute Pharyngo-Tonsillitis With Essential Oils of Some Aromatic Medical Plants. Completed NCT00610519 Phase 1, Phase 2
49 Perioperative Use of Celecoxib to Improve Pain Control in Patients Undergoing Tonsillectomy: a Randomized, Double Blind, Placebo-controlled Trial Completed NCT00583453 Phase 2 Celecoxib;Placebo
50 Analgesic Effect of Single Dose Intravenous Acetaminophen in Pediatric Patients Undergoing Tonsillectomy Completed NCT01691690 Phase 2 Acetaminophen (paracetamol);Normal Saline Flush;Midazolam;Sevoflurane;Nitrous Oxide/Oxygen;Propofol;Morphine;Ondansetron;Dexamethasone

Search NIH Clinical Center for Tonsillitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Cochrane evidence based reviews: tonsillitis

Genetic Tests for Tonsillitis

Anatomical Context for Tonsillitis

MalaCards organs/tissues related to Tonsillitis:

Tonsil, Testes, B Cells, Thyroid, T Cells, Heart, Lymph Node

Publications for Tonsillitis

Articles related to Tonsillitis:

(show top 50) (show all 5074)
# Title Authors PMID Year
Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomised controlled, open label, non-inferiority study. 61 42
31585944 2019
Gradual aggravation of idiopathic glossopharyngeal neuralgia due to chronic tonsillitis: A case report. 61 42
31027070 2019
Role of Phosphorylcholine-Specific Immunoglobulin M in Acute Upper Respiratory Tract Infections. 42
31092031 2019
MPO-ANCA-positive IgA nephropathy successfully treated with tonsillectomy. 54 61
18085396 2007
[Therapeutic effects and prognostic factors in tonsillectomy patients with IgA nephropathy]. 54 61
17373325 2007
[Hematuria and acanthocyturia in patients with diabetes]. 54 61
16372748 2005
Neutrophil chemokines in epithelial inflammatory processes of human tonsils. 54 61
15807854 2005
[Expression of human beta-defensin in palatine tonsil]. 54 61
15222256 2004
Is IgA nephropathy induced by hyperproduction of interferon-alpha? 54 61
15050119 2004
Free radicals and scavenging enzymes in chronic tonsillitis. 54 61
12958578 2003
IgA1 molecules produced by tonsillar lymphocytes are under-O-glycosylated in IgA nephropathy. 54 61
12955676 2003
Tonsillar IgA1 as a possible source of hypoglycosylated IgA1 in the serum of IgA nephropathy patients. 54 61
12748342 2003
[Oxidative profile of tonsil infection. Study of antioxidant enzymes in tonsil and blood]. 54 61
12402489 2002
Decreased serum and pharyngeal antibody levels specific to streptococcal lipoteichoic acid in children with recurrent tonsillitis. 54 61
11997155 2002
[Tonsillar and erythrocyte levels of superoxide dismutase in children with and without recurrent tonsillitis]. 54 61
11927098 2002
Polymorphisms in inflammation genes (angiotensinogen, TAP1 and TNF-beta) in psoriasis. 54 61
11194890 2000
[Detection tonsillar pathology by superoxide dismutase levels. Comparative study of surgical indications for tonsillectomy]. 54 61
11270107 2000
Induction of IgA against Haemophilus parainfluenzae antigens in tonsillar mononuclear cells from patients with IgA nephropathy. 54 61
10866131 2000
Significance of free radicals in chronic tonsillitis. 54 61
10920537 2000
Evolution of IgA deficiency to IgG subclass deficiency and common variable immunodeficiency. 54 61
10757854 2000
[The measurement of superoxide dismutase levels in recurrent tonsillitis. Its practical use]. 54 61
10502708 1999
[Therapeutic effects and prognostic factors of tonsillectomy for IgA nephropathy in long-term follow-up]. 54 61
10025123 1998
[Beta-lactamase-producing bacteria in recurrent childhood tonsillitis]. 54 61
9951080 1998
Microbial factors leading to recurrent upper respiratory tract infections. 54 61
9727652 1998
[The clinical meaning and determination of the superoxid dismutase activity and malondialehyde content in the serum of the patients suffering from chronic tonsillitis]. 54 61
11189145 1998
Bacteriology of normal and diseased tonsils assessed by fine-needle aspiration: Haemophilus influenzae and the pathogenesis of recurrent acute tonsillitis. 54 61
9597292 1998
A study of free radicals and scavenging enzyme in tonsillitis. 54 61
9066174 1996
Immunoglobulin-coated bacteria on the tonsillar surface during infectious mononucleosis. 54 61
8733454 1996
Concomitant in vivo production of 19 different cytokines in human tonsils. 54 61
7821961 1994
[Streptococcal group A carriage: new data on the characteristics of the biology of the causative agent and of the immune response of the host]. 54 61
7856351 1994
Tonsil surface and core cultures in recurrent tonsillitis: prevalence of anaerobes and beta-lactamase producing organisms. 54 61
7805681 1994
Chronic tonsillitis and IgA nephropathy. 54 61
8033611 1993
Immunohistochemical detection of co-localizing cytokine and antibody producing cells in the extrafollicular area of human palatine tonsils. 54 61
8348748 1993
Chronic tonsillitis and IgA nephropathy. Clinical study of patients with and without tonsillectomy. 54 61
8285040 1993
Effect of and indication for tonsillectomy in IgA nephropathy. 54 61
8285039 1993
Role of serum antibodies to streptococci in patients with IgA nephropathy. 54 61
8285043 1993
[Immunohistological study on human palatine tonsils in cases with pustulosis palmaris et plantaris--the quantitative study by image analyzer]. 54 61
2181093 1990
Long-term outcomes of tonsillectomy for recurrent tonsillitis in adults. 61
30908668 2020
Transoral robotic surgery using the Medrobotic Flex® system: the Adelaide experience. 61
30835042 2020
Prevalence of palatine tonsilloliths in Dominican patients of varying social classes treated in university clinics. 61
32015463 2020
[Exudative tonsillitis in children. How can we reduce the unnecessary antibiotic consumption?] 61
31902236 2020
Postoperative complications after adenotonsillectomy in two paediatric groups: Obstructive sleep apnoea syndrome and recurrent tonsillitis. 61
31235072 2020
Liu Shen Wan inhibits influenza a virus and excessive virus-induced inflammatory response via suppression of TLR4/NF-κB signaling pathway in vitro and in vivo. 61
31972325 2020
Tonsillar hypertrophy and prolapse in a child - is epiglottitis a predisposing factor for sudden unexpected death? 61
31959132 2020
Longterm results after tonsillotomy: outcome, residual symptoms and need for revision surgery. 61
31671015 2020
[Severe bacterial soft tissue infections in the head and neck region : Overview of the causes, pathogenesis, diagnostics, treatment and possible sequelae]. 61
31996943 2020
Anti-influenza A virus mechanism of three representative compounds from Flos Trollii via TLRs signaling pathways. 61
32004628 2020
Performance of recently proposed periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome criteria in a region endemic for familial Mediterranean fever. 61
31346686 2020
Ascites in a young male: idiopathic FIP1L1-PDGFRA-negative hypereosinophilic syndrome. 61
32002188 2020
Coughing up clues: 16-year-old girl with acute haemoptysis. 61
31919069 2020

Variations for Tonsillitis

Expression for Tonsillitis

Search GEO for disease gene expression data for Tonsillitis.

Pathways for Tonsillitis

Pathways related to Tonsillitis according to GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
13.96 TNF LTA IL6 IL4 IL2 IL1B
Show member pathways
13.87 TNF TLR4 LTA IL6 IL4 IL2
Show member pathways
13.69 TNF LTA IL6 IL4 IL2 IL1B
Show member pathways
13.56 TNF LTA IL6 IL4 IL2 IL1B
Show member pathways
13.51 TNF LTA IL6 IL4 IL2 IL1B
Show member pathways
Show member pathways
13.42 TNF TLR9 TLR4 TLR3 TLR10 IL4
Show member pathways
13.34 TNF TLR9 TLR4 TLR3 TLR10 IL6
Show member pathways
Show member pathways
13.08 TNF TLR4 TLR3 IL6 IL4 IL2
Show member pathways
13.07 TNF LTA IL6 IL4 IL2 IL1B
Show member pathways
13.03 TNF TLR9 TLR4 TLR3 IL6 IL2
14 12.98 TNF TLR9 TLR3 LTA IL6 IL1B
Show member pathways
Show member pathways
Show member pathways
12.85 TNF LTA IL6 IL4 IL2
Show member pathways
Show member pathways
12.82 TNF TLR4 IL6 IL4 IL2 IL1B
Show member pathways
Show member pathways
12.79 TNF IL4 IL2 IL10 IFNG CD79A
22 12.78 TNF TLR9 TLR3 IL4 IL2 IL1B
Show member pathways
Show member pathways
12.75 TNF TLR9 TLR4 IL6 IL4 IL2
Show member pathways
Show member pathways
12.58 TNF SOD1 IL6 IL4 IL2 IL1B
Show member pathways
12.58 TNF LTA IL6 IL2 IL10 CXCL8
Show member pathways
Show member pathways
12.51 IL6 IL4 IL2 IL10 IFNG
Show member pathways
12.51 TNF TLR4 IL4 IL1B IL1A IL10
Show member pathways
12.49 TNF TLR9 TLR4 TLR3 TLR10 IL6
32 12.46 TNF TLR4 IL6 IL1B CXCL8
33 12.46 TNF TLR4 IL6 IL1B CXCL8 CXCL1
34 12.46 TNF TLR9 TLR4 IL6 IL1B IL1A
35 12.45 TNF TLR4 IL1B CXCL8
36 12.44 TNF TLR9 TLR4 TLR3 TLR10 IL6
Show member pathways
Show member pathways
12.43 TNF TLR9 IL6 IL2 IL1B IL10
39 12.42 TNF LTA IL6 IL2
Show member pathways
12.42 TNF TLR9 TLR4 IL6 IL4 IL1B
41 12.4 TNF IL6 IL1B IL1A IL10 CXCL8
Show member pathways
Show member pathways
Show member pathways
12.31 TNF TLR4 SOD1 IL6 IL4 IL1B
Show member pathways
12.3 TLR9 TLR4 TLR3 TLR10 IL2 IL1B
46 12.28 TNF TLR4 IL6 IL2 IL1B IL10
47 12.25 TNF IL6 IL4 IL2 IL10 IFNG
48 12.24 TNF IL6 IL4 IL1B IL1A IL10
50 12.21 TNF IL1B IL1A IFNG

GO Terms for Tonsillitis

Cellular components related to Tonsillitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 TNF TLR9 SOD1 LTA IL6 IL4
2 extracellular space GO:0005615 9.5 TNF TLR3 SOD1 LTA IL6 IL4

Biological processes related to Tonsillitis according to GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.39 TLR9 TLR4 TLR3 TLR10 LTA IL6
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.3 TNF TLR9 TLR4 TLR3 IL6 IL4
3 immune system process GO:0002376 10.24 TLR9 TLR4 TLR3 TLR10 IL2 CD79A
4 negative regulation of cell proliferation GO:0008285 10.18 IL6 IL1B IL1A IL10 CXCL8 CXCL1
5 positive regulation of apoptotic process GO:0043065 10.16 TNF TLR3 SOD1 LTA IL6
6 positive regulation of gene expression GO:0010628 10.11 TNF TLR9 TLR4 TLR3 IL6 IL4
7 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.09 TNF TLR9 TLR4 TLR3 IL1B IL1A
8 cell-cell signaling GO:0007267 10.08 LTA IL2 IL1B CXCL6
9 response to lipopolysaccharide GO:0032496 10.08 TLR4 LTA IL1B IL10 CXCL6
10 defense response to bacterium GO:0042742 10.08 TNF TLR9 TLR4 TLR3 IL10 DEFB1
11 defense response to virus GO:0051607 10.07 TLR9 TLR3 IL6 IFNG
12 positive regulation of protein phosphorylation GO:0001934 10.07 TNF IL2 IL1B IFNG
13 chemotaxis GO:0006935 10.06 DEFB1 CXCL8 CXCL6 CXCL1
14 defense response GO:0006952 10.06 TNF TLR3 DEFB1 CXCL8 CXCL6 CXCL1
15 positive regulation of angiogenesis GO:0045766 10.05 TLR3 IL1B IL1A CXCL8
16 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.04 TNF TLR9 TLR4 TLR3 IL6 IL1B
17 activation of MAPK activity GO:0000187 10.03 TNF TLR4 SOD1 IL1B
18 positive regulation of DNA-binding transcription factor activity GO:0051091 10.03 TNF IL6 IL1B IL10
19 neutrophil chemotaxis GO:0030593 10.03 IL1B IL1A CXCL8 CXCL6 CXCL1
20 defense response to Gram-positive bacterium GO:0050830 10.02 TNF LTA IL6 DEFB1
21 cytokine-mediated signaling pathway GO:0019221 10.02 TNF IL6 IL4 IL2 IL1B IL1A
22 defense response to Gram-negative bacterium GO:0050829 10 TLR9 TLR4 IL6 DEFB1
23 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.99 DEFB1 CXCL8 CXCL6 CXCL1
24 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.99 TNF IL6 IL4 IL2 IFNG
25 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.98 TNF TLR9 TLR4 TLR3
26 positive regulation of T cell proliferation GO:0042102 9.98 IL6 IL4 IL2 IL1B
27 cellular response to mechanical stimulus GO:0071260 9.96 TLR4 TLR3 IL1B
28 B cell differentiation GO:0030183 9.96 IL4 IL10 CD79A
29 humoral immune response GO:0006959 9.96 TNF LTA IL6 IFNG
30 positive regulation of phagocytosis GO:0050766 9.96 TNF SOD1 IL1B IFNG
31 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.96 TNF TLR9 TLR4 TLR3 IL1B
32 chemokine-mediated signaling pathway GO:0070098 9.95 CXCL8 CXCL6 CXCL1
33 regulation of insulin secretion GO:0050796 9.95 TNF IL1B IFNG
34 response to glucocorticoid GO:0051384 9.95 TNF IL6 IL10
35 apoptotic signaling pathway GO:0097190 9.95 TNF TLR4 TLR3
36 positive regulation of nitric oxide biosynthetic process GO:0045429 9.95 TNF TLR4 IL1B IFNG
37 toll-like receptor signaling pathway GO:0002224 9.95 TLR9 TLR4 TLR3 TLR10
38 positive regulation of JNK cascade GO:0046330 9.95 TNF TLR9 TLR4 TLR3 IL1B IL1A
39 positive regulation of tumor necrosis factor production GO:0032760 9.94 TLR9 TLR4 TLR3
40 positive regulation of B cell proliferation GO:0030890 9.94 TLR9 TLR4 IL4 IL2
41 interleukin-12-mediated signaling pathway GO:0035722 9.93 SOD1 IL10 IFNG
42 extrinsic apoptotic signaling pathway GO:0097191 9.93 TNF TLR3 IFNG
43 negative regulation of interleukin-6 production GO:0032715 9.93 TNF TLR9 TLR4 IL10
44 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.92 TNF IL1B IL1A
45 positive regulation of interleukin-6 secretion GO:2000778 9.92 TNF TLR4 IL1B
46 lipopolysaccharide-mediated signaling pathway GO:0031663 9.92 TNF TLR4 IL1B
47 positive regulation of interleukin-12 production GO:0032735 9.92 TLR9 TLR4 TLR3 IFNG
48 positive regulation of interferon-gamma production GO:0032729 9.92 TNF TLR4 LTA IL2 IL1B
49 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.91 IL2 IL1B IL1A
50 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.91 TLR9 TLR4 TLR10

Molecular functions related to Tonsillitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.28 TNF TLR9 TLR4 TLR3 TLR10 SOD1
2 identical protein binding GO:0042802 9.95 TNF TLR4 TLR3 TLR10 SOD1 LACTB
3 transmembrane signaling receptor activity GO:0004888 9.65 TLR9 TLR4 TLR3 TLR10 CD79A
4 chemokine activity GO:0008009 9.54 CXCL8 CXCL6 CXCL1
5 cytokine activity GO:0005125 9.4 TNF LTA IL6 IL4 IL2 IL1B
6 growth factor activity GO:0008083 9.35 IL6 IL4 IL2 IL10 CXCL1
7 interleukin-1 receptor binding GO:0005149 9.33 TLR9 IL1B IL1A

Sources for Tonsillitis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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