MCID: TNS005
MIFTS: 60

Tonsillitis

Categories: Respiratory diseases, Oral diseases

Aliases & Classifications for Tonsillitis

MalaCards integrated aliases for Tonsillitis:

Name: Tonsillitis 12 55 43 44 15 63 73
Chronic Tonsillitis 12 55 73
Throat Infection - Tonsillitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10456
ICD10 33 J35.01 J35.0
ICD9CM 35 474.00
MeSH 44 D014069
NCIt 50 C116006

Summaries for Tonsillitis

MedlinePlus : 43 What are tonsils? Tonsils are lumps of tissue at the back of the throat. There are two of them, one on each side. Along with the adenoids, tonsils are part of the lymphatic system. The lymphatic system clears away infection and keeps body fluids in balance. Tonsils and adenoids work by trapping the germs coming in through the mouth and nose. What is tonsillitis? Tonsillitis is an inflammation (swelling) of the tonsils. Sometimes along with tonsillitis, the adenoids are also swollen. What causes tonsillitis? The cause of tonsillitis is usually a viral infection. Bacterial infections such as strep throat can also cause tonsillitis. Who gets tonsillitis? Tonsillitis is most common in children over age two. Almost every child in the United States gets it at least once. Tonsillitis caused by bacteria is more common in kids ages 5-15. Tonsillitis caused by a virus is more common in younger children. Adults can get tonsillitis, but it is not very common. Is tonsillitis contagious? Although tonsillitis is not contagious, the viruses and bacteria that cause it are contagious. Frequent handwashing can help prevent spreading or catching the infections. What are the symptoms of tonsillitis? The symptoms of tonsillitis include A sore throat, which may be severe Red, swollen tonsils Trouble swallowing A white or yellow coating on the tonsils Swollen glands in the neck Fever Bad breath When should I get medical help for my child? You should call your health care provider if your child Has a sore throat for more than two days Has trouble or pain when swallowing Feels very sick or very weak You should get emergency care right away if your child Has trouble breathing Starts drooling Has a lot of trouble swallowing How is tonsillitis diagnosed? To diagnose tonsillitis, your child's health care provider will first ask you about your child's symptoms and medical history. The provider will look at your child's throat and neck, checking for things such as redness or white spots on the tonsils and swollen lymph nodes. Your child will probably also have one or more tests to check for strep throat, since it can cause tonsillitis and it requires treatment. It could be a rapid strep test, a throat culture, or both. For both tests, the provider uses a cotton swab to collect a sample of fluids from your child's tonsils and the back of the throat. With the rapid strep test, testing is done in the office, and you get the results within minutes. The throat culture is done in a lab, and it usually takes a few days to get the results. The throat culture is a more reliable test. So sometimes if the rapid strep test is negative (meaning that it does not show any strep bacteria), the provider will also do a throat culture just to make sure that your child does not have strep. What are the treatments for tonsillitis? Treatment for tonsillitis depends on the cause. If the cause is a virus, there is no medicine to treat it. If the cause is a bacterial infection, such as strep throat, your child will need to take antibiotics. It is important for your child to finish the antibiotics even if he or she feels better. If treatment stops too soon, some bacteria may survive and re-infect your child. No matter what is causing the tonsillitis, there are some things you can do to help your child feel better. Make sure that your child Gets a lot of rest Drinks plenty of fluids Tries eating soft foods if it hurts to swallow Tries eating warm liquids or cold foods like popsicles to soothe the throat Isn't around cigarette smoke or do anything else that could irritate the throat Sleeps in a room with a humidifier Gargles with saltwater Sucks on a lozenge (but do not give them to children under four; they can choke on them) Takes an over-the-counter pain reliever such as acetaminophen. Children and teenagers should not take aspirin. In some cases, your child may need a tonsillectomy. What is a tonsillectomy and why might my child need one? A tonsillectomy is surgery to remove the tonsils. Your child might need it if he or she Keeps getting tonsillitis Has bacterial tonsillitis that does not get better with antibiotics Has tonsils are too big, and are causing trouble breathing or swallowing Your child usually gets the surgery and goes home later that day. Very young children and people who have complications may need to stay in the hospital overnight. It can take a week or two before your child completely recovers from the surgery.

MalaCards based summary : Tonsillitis, also known as chronic tonsillitis, is related to sleep apnea and extramedullary plasmacytoma, and has symptoms including sore throat An important gene associated with Tonsillitis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Cedax and Sufentanil have been mentioned in the context of this disorder. Affiliated tissues include tonsil, lymph node and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

PubMed Health : 63 About tonsillitis: Sore throats can have a range of causes. Common cold viruses are usually to blame. In rarer cases, sore throats are caused by an infection of the tonsils (tonsillitis). This infection is often bacterial, or sometimes viral. But it isn’t easy to tell what kind of germs are responsible for the infection. Children and teenagers are much more susceptible to tonsillitis than adults are.Acute tonsillitis starts suddenly and usually goes away again within one to two weeks. But tonsillitis can return several times over the course of a year and may become chronic. In chronic tonsillitis, the bacteria become permanently settled in the tonsils, which are always slightly inflamed as a result. People who have chronic tonsillitis might keep getting acute infections with more severe symptoms too. Having chronic tonsillitis can be a real problem, and may also lead to complications in rare cases.

Wikipedia : 76 Tonsillitis is inflammation of the tonsils, typically of rapid onset. It is a type of pharyngitis.... more...

Related Diseases for Tonsillitis

Diseases related to Tonsillitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 508)
# Related Disease Score Top Affiliating Genes
1 sleep apnea 30.5 CXCL8 IL6 TNF
2 extramedullary plasmacytoma 30.0 IL2 IL6
3 leukemia, chronic lymphocytic 29.7 IL1A IL2 IL4 TLR9
4 haemophilus influenzae 29.6 CXCL8 IL1B TNF
5 rhinitis 29.5 CXCL8 IL4 TLR9
6 plasmacytoma 29.4 CD79A IL2 IL6
7 allergic rhinitis 29.2 CXCL8 IFNG IL4
8 hemophagocytic lymphohistiocytosis 28.9 CXCL8 IFNG TNF
9 lymphadenitis 28.9 CXCL8 IFNG IL1B TNF
10 measles 28.8 IFNG IL2 IL4 IL6
11 laryngitis 28.8 IL1B IL6 TNF
12 orofacial granulomatosis 28.8 CD79A IFNG IL4 TNF
13 rheumatic heart disease 28.6 IL4 IL6 TNF
14 bronchitis 28.5 CD79A CXCL8 TNF
15 gingival disease 28.5 CD79A IL1B IL6
16 helicobacter pylori infection 28.5 CXCL8 IFNG IL1B TNF
17 fasciitis 28.5 CXCL8 IL6 TNF
18 reactive arthritis 28.3 CD79A IFNG IL6 TNF
19 aphthous stomatitis 28.3 IL1B IL4 IL6 TNF
20 necrotizing fasciitis 28.2 CXCL8 IL2 IL6 LTA
21 post-transplant lymphoproliferative disease 28.2 IL1A IL6 LTA TNF
22 crohn's disease 28.1 IL1B IL6 TLR9 TNF
23 leishmaniasis 28.1 IFNG IL1A IL1B IL4 TLR9 TNF
24 dermatitis, atopic 27.7 CXCL8 IFNG IL2 IL4 TLR9 TNF
25 psoriatic arthritis 27.5 IL1A IL1B IL6 LTA TNF
26 osteoporosis 27.5 IFNG IL1A IL1B IL6 TNF
27 otitis media 27.5 CD79A CXCL8 IL1B IL6 TNF
28 pneumonia 27.4 CXCL8 IL1B IL6 TLR9 TNF
29 bacterial meningitis 27.1 CXCL8 IL1B IL6 TLR9 TNF
30 ulcerative colitis 27.0 CXCL8 IL1B IL2 IL6 TNF
31 chlamydia 26.7 CD79A CXCL8 IFNG IL1B IL6 TNF
32 arthritis 26.7 CXCL8 IFNG IL1A IL1B IL6 LTA
33 meningitis 26.6 CXCL8 IFNG IL1B IL6 TLR9 TNF
34 gastroenteritis 26.5 CXCL8 IFNG IL1B IL4 IL6 TNF
35 toxoplasmosis 26.3 CD79A IFNG IL1B IL4 IL6 TLR9
36 colitis 25.6 CXCL8 IFNG IL1B IL2 IL4 IL6
37 gingivitis 25.5 CD79A CXCL8 IL1A IL1B IL4 IL6
38 toxic shock syndrome 25.4 CXCL8 IFNG IL1B IL2 IL4 IL6
39 psoriasis 25.0 CXCL8 IFNG IL1A IL1B IL2 IL4
40 rheumatoid arthritis 24.8 CD79A CXCL8 IFNG IL1A IL1B IL2
41 tonsil cancer 12.3
42 tonsil squamous cell carcinoma 12.3
43 tongue cancer 11.6
44 adenoid hypertrophy 11.5
45 chiari malformation type i 11.3
46 chiari malformation 11.1
47 lemierre's syndrome 11.1
48 rheumatic fever 11.1
49 oropharynx cancer 11.1
50 tangier disease 11.1

Graphical network of the top 20 diseases related to Tonsillitis:



Diseases related to Tonsillitis

Symptoms & Phenotypes for Tonsillitis

UMLS symptoms related to Tonsillitis:


sore throat

GenomeRNAi Phenotypes related to Tonsillitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 SOD1 TNF CXCL8 IL1A IL1B IL2
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 SOD1 TNF CXCL8 IL1A IL1B IL2

MGI Mouse Phenotypes related to Tonsillitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.14 TLR9 TNF IL6 IL1A LTA IL1B
2 homeostasis/metabolism MP:0005376 10.11 TNF SOD1 TLR9 IL6 IL1A LTA
3 immune system MP:0005387 10.06 TLR9 TNF IL6 IL1A LTA IL1B
4 cardiovascular system MP:0005385 10.03 TNF SOD1 IFNG IL6 IL1A LTA
5 integument MP:0010771 9.8 TNF SOD1 IFNG IL6 IL1A IL1B
6 liver/biliary system MP:0005370 9.76 TNF IL6 LTA SOD1 IL2 CD79A
7 neoplasm MP:0002006 9.56 TNF IL6 IL1A IL1B SOD1 IL2
8 vision/eye MP:0005391 9.17 TNF SOD1 IFNG IL6 LTA IL2

Drugs & Therapeutics for Tonsillitis

PubMedHealth treatment related to Tonsillitis: 63

The main goal of treatment is to relieve symptoms and prevent complications. The following medicines can be used to treat acute tonsillitis:Medication for relieving pain and lowering fever, like ibuprofen or acetaminophen (paracetamol)Antibiotics (for bacterial tonsillitis only)Antibiotics can make the tonsillitis go away a little sooner. They can also lower the risk of developing complications. But they have side effects too.Some people relieve their symptoms by sucking on throat lozenges, or using home remedies such as a neck wrap or gargling with salt water or tea.Recurrent tonsillitis can also be treated with painkillers or antibiotics. The surgical removal of tonsils is a treatment option for people who frequently get tonsillitis.

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Cedax 18 CEFTIBUTEN DIHYDRATE Schering-Plough December 1995

Drugs for Tonsillitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 194)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
2
Acetaminophen Approved Phase 4,Phase 2,Not Applicable 103-90-2 1983
3
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
4
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 26787-78-0 33613
5
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 447043
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
7
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
9
Codeine Approved, Illicit Phase 4 76-57-3 5284371
10
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
11
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
12
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
13
Clarithromycin Approved Phase 4,Phase 1 81103-11-9 84029
14
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
15
Penicillin V Approved, Vet_approved Phase 4,Phase 3,Not Applicable 87-08-1 6869
16
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
17
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
18
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
19
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
20
Racepinephrine Approved Phase 4 329-65-7 838
21
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
22
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
23
Ibuprofen Approved Phase 4 15687-27-1 3672
24
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
25 Tinoridine Investigational Phase 4 24237-54-5
26 Andrographolide Investigational Phase 4 5508-58-7
27
Propyl Gallate Investigational Phase 4 121-79-9 4947
28 Adjuvants, Anesthesia Phase 4,Phase 2,Not Applicable
29 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
30 Analgesics, Opioid Phase 4,Phase 2,Not Applicable
31 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
32 Anesthetics, General Phase 4,Phase 2,Not Applicable
33 Anesthetics, Intravenous Phase 4,Phase 2,Not Applicable
34 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
35 Narcotics Phase 4,Phase 2,Not Applicable
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
37 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Not Applicable
38 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Not Applicable
40 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Not Applicable
41 Anesthetics, Local Phase 4,Phase 3,Not Applicable
42 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
43 Fibrinolytic Agents Phase 4,Phase 3,Not Applicable
44 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Not Applicable
45 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Not Applicable
46 Adrenergic Agents Phase 4,Not Applicable
47 Adrenergic Agonists Phase 4,Not Applicable
48 Adrenergic alpha-2 Receptor Agonists Phase 4,Not Applicable
49 Adrenergic alpha-Agonists Phase 4,Not Applicable
50 BB 1101 Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 100)
# Name Status NCT ID Phase Drugs
1 Randomized Controlled Study of Plasmaknife Tonsillectomy Versus Monopolar Tonsillectomy Unknown status NCT00466544 Phase 4
2 Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Tonsillectomy or Adeno-tonsillectomy in Children Unknown status NCT02205580 Phase 4 continuous intravenous sufentanil 0.02μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.03μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.04μg•kg-1•h-1 infusion
3 Multicenter, Open, Randomized Comparative Trial To Compare The Efficacy Of Azithromycin Versus Amoxicillin In Children With Strep Throat Completed NCT00643539 Phase 4 Zithromax;Clamoxyl
4 Efficacy of Tinoridine in Treating Pain and Inflammation in Adults Completed NCT01224756 Phase 4 Tinoridine HCl;Placebo
5 Dexmedetomidine for Immediate Perioperative Analgesia in Pediatric Patients Undergoing Tonsillectomy Completed NCT00654511 Phase 4 Fentanyl;Fentanyl;Dexmedetomidine;Dexmedetomidine
6 A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy Completed NCT01267136 Phase 4 Codeine with acetaminophen;Tramadol suspension
7 Acetaminophen's Efficacy For Post-operative Pain Completed NCT01721486 Phase 4 IV acetaminophen;PO acetaminophen
8 Recurrent Throat Infections and Tonsillectomy Completed NCT00547391 Phase 4
9 EXPAREL® for Pain After Tonsillectomy Completed NCT02444533 Phase 4 Liposomal Bupivacaine
10 Placebo and Active Controlled Study to Compare the Efficacy of Aspirin and Paracetamol in Treatment of Sore Throat Associated With a Common Cold Completed NCT01465009 Phase 4 Acetylsalicylic acid (Aspirin, BAYE4465);Paracetamol;Placebo
11 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
12 DIAMANTE - Diseases Infectious Analysis Microflora Antibiotic Effect Completed NCT00424905 Phase 4 Bacillus clausii
13 Clinical Trial for the Assessment of Delayed Antibiotic Treatment Strategies Completed NCT01363531 Phase 4
14 Evaluate the Efficacy and Safety of Andrographolide Sulfonate in Patients With Acute Tonsillitis Recruiting NCT03134443 Phase 4 Andrographolide sulfonate;Andrographolide sulfonate simulation
15 Study of 5 and 10 Days Treatment With Penicillin Against Sore Throat Caused by Streptococci Recruiting NCT02712307 Phase 4 Phenoxymethylpenicillin
16 Perioperative Tonsillectomy Protocol Development Recruiting NCT03323047 Phase 4 Acetaminophen;Low-dose Dexamethasone;Placebo Oral Tablet;High-Dose Dexamethasone
17 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Recruiting NCT02162433 Phase 4 Normal Saline;Dexmedetomidine
18 Post-tonsillectomy Pain Control in Adults Recruiting NCT02358850 Phase 4 Norco (Hydrocodone and Acetaminophen);Percocet (Oxycodone and Acetaminophen);Dilaudid (hydromorphone);Tylenol (Acetaminophen)
19 EXPAREL Post-tonsillectomy Clinical Trial Recruiting NCT03420638 Phase 4 Adjunct Exparel (bupivacaine liposome suspension 1.3%)
20 Effect of OM-85 on Respiratory Tract Infections and Adenoid Tissue in Children With Adenoid Hypertrophy Not yet recruiting NCT03243565 Phase 4
21 Evaluation of Inflammatory Symptoms Reduction With Amoxicillin + Ketoprofen in Acute Pharyngeal Tonsillitis in Pediatric Patients Terminated NCT00799838 Phase 4 Ketoprofen;Placebo (for Ketoprofen);Amoxicillin
22 Post-operative Pain Control After Pediatric Adenotonsillectomy Terminated NCT02296840 Phase 4 Ibuprofen;Hydrocodone-Acetaminophen
23 Lactobacillus Reuteri DSM 17938 and Prevention of Respiratory and Gastrointestinal Infections in Mexican Infants Unknown status NCT01249911 Phase 3
24 Efficacy Study of Pristinamycin Versus Amoxicillin to Treat Tonsillitis Induced by Streptococcus in Children Completed NCT00393744 Phase 3 pristinamycin;amoxicillin
25 A Trial Of Azithromycin SR For The Treatment Of Laryngopharyngitis or Tonsillitis or Acute Bacterial Rhinosinusitis Completed NCT00393835 Phase 3 Azithromycin SR
26 A Multicenter, Randomized, Double-Blind, Double-Dummy Study Of Azithromycin SR Versus Amoxicillin For The Treatment Of Strep Throat In Children Completed NCT00643149 Phase 3 amoxicillin;azithromycin SR
27 A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial of Azithromycin Sustained Release Versus 3-Day Azithromycin for the Treatment of Strep Throat in Adolescents and Adults Completed NCT00644293 Phase 3 azithromycin (Zithromax);placebo;azithromycin SR;placebo
28 APC-111 Once a Day (QD) for 7 Days vs. Penicillin Taken Four Times a Day (QID) for 10 Days in Patients With Strep Throat Completed NCT00095368 Phase 3 Amoxicillin Pulsatile Release Multiparticulate Tablet (drug)
29 APC-111 MP Tablet Once a Day vs.Penicillin VK Four Times a Day Both for 10 Days in Patients With Strep Throat Completed NCT00242281 Phase 3 APC-111 MP Tablet, 775 mg
30 Active and Placebo Controlled Study to Test the Efficacy and Safety of an Aspirin-Lidocaine Lozenge in the Symptomatic Treatment of Sore Throat Associated With a Common Cold Completed NCT01361399 Phase 3 Acetylsalicylic acid (Aspirin, BAYE4465) & Lidocain;Acetylsalicylic Acid (Aspirin, BAYE4465);Lidocain;Placebo
31 A Long-Term Extension Study of RoActemra/Actemra (Tocilizumab) in Patients With Juvenile Idiopathic Arthritis From France Who Completed WA19977 Core Study Completed NCT01673919 Phase 3 tocilizumab [RoActemra/Actemra]
32 CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study Completed NCT01948856 Phase 3 J022X ST;Placebo
33 Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial Completed NCT01304927 Phase 2, Phase 3 Cholecalciferol and calcium
34 E. Coli Nissle 1917 - Suspension for Infection Prophylaxis Recruiting NCT02802059 Phase 3 EcN-Suspension;Placebo
35 TELI TON - Telithromycin in Tonsillitis Terminated NCT00315042 Phase 3 Telithromycin (HMR3647);Penicillin
36 TELI TAD - Telithromycin in Tonsillitis in Adolescents and Adults Terminated NCT00315549 Phase 3 Telithromycin;Penicillin
37 Comparison of Floseal Hemostasis Tonsillectomy With Coblation Tonsillectomy and Cautery Hemostasis Tonsillectomy Withdrawn NCT00459927 Phase 2, Phase 3
38 Evaluation of Coblation Channeling in Treating Chronic Tonsillitis Unknown status NCT01193790 Phase 2
39 A Phase I/II to Assess Safety, Tolerability and Efficacy of DL-lactic Acid Syrup in Children With Recurrent Tonsillitis Completed NCT01988558 Phase 1, Phase 2 DL - Lactic Acid
40 Treatment of Acute Pharyngo-Tonsillitis With Essential Oils of Aromatic Plants Completed NCT00610519 Phase 1, Phase 2
41 Efficacy and Safety of Meloxicam vs. Naproxen Sodium in Patients With Acute Non Bacterial Pharyngitis or Pharyngo-tonsillitis Completed NCT02183038 Phase 2 Meloxicam low;Meloxicam high;Naproxen sodium;Meloxicam placebo low;Meloxicam placebo high;Naproxen sodium placebo
42 Celecoxib as a Post-tonsillectomy Pain Medication Completed NCT00583453 Phase 2 Celecoxib;Placebo
43 Analgesic Effect of IV Acetaminophen in Tonsillectomies Completed NCT01691690 Phase 2 Acetaminophen (paracetamol);Normal Saline Flush;Midazolam;Sevoflurane;Nitrous Oxide/Oxygen;Propofol;Morphine;Ondansetron;Dexamethasone
44 PASS Study To Evaluate The Potential Of Zithromax To Cause Ocular Problems In Pediatric Patients Terminated NCT01919996 Phase 2 Azithromycin
45 Evaluate Effects of Multiple Doses of Rifampin and Clarithromycin on the Single Dose Pharmacokinetics of Deflazacort Completed NCT02286635 Phase 1 Deflazacort and rifampin;Deflazacort and Clarithromycin
46 Controlled Human Infection for Vaccination Against Streptococcus Pyogenes Recruiting NCT03361163 Phase 1
47 Procalcitonin-guided Detection of Streptococcal Acute Tonsillitis Unknown status NCT01657968
48 Tonsillectomy in Recurrent Tonsillitis Unknown status NCT00136877 Not Applicable
49 Vitamin D Levels in Children Undergoing Adenotonsillectomies and Controls Unknown status NCT00829972
50 Influence of 0.75% Ropivacaine Topicalization on Emergence Agitation in Children Unknown status NCT02848287 Not Applicable normal saline;ropivacaine

Search NIH Clinical Center for Tonsillitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: tonsillitis

Genetic Tests for Tonsillitis

Anatomical Context for Tonsillitis

MalaCards organs/tissues related to Tonsillitis:

41
Tonsil, Lymph Node, Testes, B Cells, T Cells, Tongue, Neutrophil

Publications for Tonsillitis

Articles related to Tonsillitis:

(show top 50) (show all 998)
# Title Authors Year
1
Antibiotics for recurrent acute pharyngo-tonsillitis: systematic review. ( 29651614 )
2018
2
Use of Streptococcus salivarius K12 to reduce the incidence pharyngo-tonsillitis and acute otitis media in children: a retrospective analysis in not-recurrent pediatric subjects. ( 29322750 )
2018
3
Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis. ( 29942488 )
2018
4
Psoriasis, chronic tonsillitis, and biofilms: Tonsillar pathologic findings supporting a microbial hypothesis. ( 29554401 )
2018
5
Tonsil-derived mesenchymal stem cell-embedded in situ crosslinkable gelatin hydrogel therapy recovers postmenopausal osteoporosis through bone regeneration. ( 29975738 )
2018
6
Tonsillitis exacerbates renal injury in IgA nephropathy through promoting Th22 cells chemotaxis. ( 29549623 )
2018
7
Diagnostic role of mean platelet volume in tonsillitis with and without peritonsillar abscess. ( 29888695 )
2018
8
Base of tongue cancer-is it tongue cancer located at the base of the tongue, or is it a type of lingual tonsil cancer? The perspective from a genomic analysis. ( 29452725 )
2018
9
LipschA1tz ulcer and group A streptococcal tonsillitis. ( 29880620 )
2018
10
Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma. ( 29338018 )
2018
11
Is Scottish Intercollegiate Guidelines Network guidance for GP management of tonsillitis suitable? A qualitative study. ( 29590327 )
2018
12
Differentiating Tonsil Cancer from Benign Tonsillar Hypertrophy. ( 29605393 )
2018
13
Assessment of Volatile Sulfur Compounds in Adult and Pediatric Chronic Tonsillitis Patients Receiving Tonsillectomy. ( 29719951 )
2018
14
Detection of GSK-3I^ activation index in pediatric chronic tonsillitis is an indicator for chronic recurrent inflammation. ( 29530430 )
2018
15
Pediatric Tonsil Cancer: A National and Institutional Perspective. ( 29571929 )
2018
16
A Taiwanese population-based study on the association between chronic tonsillitis and tonsil cancer. ( 29484140 )
2018
17
Algorithm of adenoiditis treatment in adults, depending on the pharyngeal tonsil hypertrophy stage. ( 29783226 )
2018
18
Treatment Challenges of Group A Beta-hemolytic Streptococcal Pharyngo-Tonsillitis. ( 28680500 )
2017
19
Papillary squamous cell carcinoma of the palatine tonsil: a rare cancer of the head and neck. ( 28530265 )
2017
20
Staphylococcus aureus isolated from tonsillectomized adult patients with recurrent tonsillitis. ( 27862322 )
2017
21
A white man with Kikuchi-Fujimoto disease mimicking lymphoma, preceded by frequent episodes of tonsillitis: a case report. ( 28189144 )
2017
22
Multimodality Treatment of Early-Stage Tonsil Cancer. ( 28669307 )
2017
23
Is tonsillectomy recommended in adults with recurrent tonsillitis? ( 28408369 )
2017
24
Amoxicillin and clavulanate potassium in treating children with suppurative tonsillitis. ( 28952295 )
2017
25
Management of recurrent tonsillitis in children. ( 28385329 )
2017
26
Measles: A missed cause of acute tonsillitis. ( 29121387 )
2017
27
A comparison of tonsillar surface swabbing, fine-needle aspiration core sampling, and dissected tonsillar core biopsy culture in children with recurrent tonsillitis. ( 28636739 )
2017
28
Correction: The carriage of interleukin-1B-31*C allele plus Staphylococcus aureus and Haemophilus influenzae increases the risk of recurrent tonsillitis in a Mexican population. ( 29023596 )
2017
29
The effect of tonsillectomy on the morbidity from recurrent tonsillitis. ( 28199053 )
2017
30
Unique histologic features of tonsils from patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 28748511 )
2017
31
Triple-modality treatment in patients with advanced stage tonsil cancer. ( 28440876 )
2017
32
Prevalence of synchronous bilateral tonsil squamous cell carcinoma: A retrospective study. ( 28891195 )
2017
33
Inverse relationship between toxic shock syndrome toxin-1 antibodies and interferon-I^ and interleukin-6 in peripheral blood mononuclear cells from patients with pediatric tonsillitis caused by Staphylococcus aureus. ( 28483238 )
2017
34
The role of environmental tobacco exposure and Helicobacter pylori infection in the risk of chronic tonsillitis in children. ( 28380174 )
2017
35
The Impact of Tobacco Smoking Upon Chronic/Recurrent Tonsillitis and Post Tonsillectomy Bleeding. ( 28382125 )
2017
36
Hepatoid adenocarcinoma of the lung metastasizing to the tonsil. ( 28529745 )
2017
37
A Retrospective Cohort Study of Glossopharyngeal Nerve Taste in Children with Recurrent Acute Tonsillitis. ( 28045639 )
2017
38
The effect of tonsillotomy on chronic recurrent tonsillitis in children. ( 28471689 )
2017
39
Hyperplasia and the degree and activity of inflammation in chronic recurrent tonsillitis: a histopathological study. ( 28439693 )
2017
40
Helicobacter pylori in the tonsillar tissue: a possible association with chronic tonsillitis and laryngopharyngeal reflux. ( 28318453 )
2017
41
Immune thrombocytopenia of childhood responsive to tonsillectomy in the setting of chronic tonsillitis: A case report and literature review. ( 28648251 )
2017
42
Evidence Based Practice in Using Antibiotics for Acute Tonsillitis in Primary Care Practice. ( 28991775 )
2017
43
Follicular dendritic cell sarcoma of the head and neck. Literature review and report of the tonsil occurrence in a Ugandan patient. ( 28748971 )
2017
44
Vibrio vulnificus tonsillitis after swimming in the Gulf of Mexico. ( 28659373 )
2017
45
Efficacy of minimally invasive tonsil surgery for treatment of obstructive sleep apnea-hypopnea syndrome in children. ( 28443988 )
2017
46
The carriage of interleukin-1B-31*C allele plus Staphylococcus aureus and Haemophilus influenzae increases the risk of recurrent tonsillitis in a Mexican population. ( 28542534 )
2017
47
A rare complication of tonsillitis: septic arthritis of the temporomandibular joint. ( 28461120 )
2017
48
Effectiveness of an add-on treatment with the homeopathic medication SilAtro-5-90 in recurrent tonsillitis: An international, pragmatic, randomized, controlled clinical trial. ( 28779928 )
2017
49
Resolution of recurrent tonsillitis in a non-smoker who became a vaper. A case study and new hypothesis. ( 29150279 )
2017
50
Staging Neck Dissection and Transoral Robotic Surgery Treatment Algorithm in Palatine Tonsil Cancer. ( 29160154 )
2017

Variations for Tonsillitis

Expression for Tonsillitis

Search GEO for disease gene expression data for Tonsillitis.

Pathways for Tonsillitis

Pathways related to Tonsillitis according to GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CD79A CXCL8 DEFB1 IFNG IL1A IL1B
2
Show member pathways
13.83 CXCL8 IL1A IL1B IL2 IL4 IL6
3
Show member pathways
13.72 CXCL8 IFNG IL1A IL1B IL2 IL4
4
Show member pathways
13.59 CXCL8 IFNG IL1A IL1B IL2 IL4
5
Show member pathways
13.47 CXCL8 IL1A IL1B IL2 IL4 IL6
6
Show member pathways
13.46 CXCL8 IFNG IL1A IL1B IL2 IL4
7
Show member pathways
13.39 CXCL8 IL1A IL1B IL2 IL4 IL6
8
Show member pathways
13.13 CXCL8 IFNG IL1B IL2 IL6 TLR10
9
Show member pathways
12.94 CXCL8 IFNG IL1A IL1B IL2 IL4
10
Show member pathways
12.93 IL2 IL4 IL6 LTA TNF
11 12.87 CXCL8 IFNG IL2 IL4 IL6
12
Show member pathways
12.81 CXCL8 IFNG IL1B IL6 TNF
13
Show member pathways
12.81 CD79A IFNG IL1A IL1B IL2 IL4
14
Show member pathways
12.8 IL1A IL1B IL2 IL6 LTA TLR10
15
Show member pathways
12.74 IFNG IL1A IL1B LTA TNF
16 12.68 CD79A IFNG IL1B IL2 IL4 TLR9
17
Show member pathways
12.67 IFNG IL1B IL2 IL6 TNF
18
Show member pathways
12.65 IL1A IL1B LTA TLR10 TLR9 TNF
19
Show member pathways
12.64 CXCL8 IFNG IL1A IL1B IL2 IL4
20
Show member pathways
12.58 IFNG IL1A IL1B IL2 IL4 IL6
21
Show member pathways
12.57 CXCL8 IFNG IL1A IL1B IL2 IL4
22
Show member pathways
12.56 IFNG IL1A IL1B IL2 IL4 IL6
23
Show member pathways
12.54 IFNG IL2 IL4 TNF
24
Show member pathways
12.49 CXCL8 IFNG IL1B IL4 IL6 TNF
25 12.47 IL2 IL6 LTA TNF
26
Show member pathways
12.44 IFNG IL1B IL2 IL4 IL6 SOD1
27
Show member pathways
12.41 CXCL8 IL1A IL6 TLR10 TLR9 TNF
28
Show member pathways
12.41 CXCL8 IFNG IL1A IL1B IL6 TNF
29
Show member pathways
12.39 IFNG IL1A IL1B IL4 TNF
30 12.37 IFNG IL1A IL1B IL6 TLR9 TNF
31
Show member pathways
12.36 CXCL8 IL1A IL1B IL6 TNF
32
Show member pathways
12.35 IL1B IL2 IL6 TLR9 TNF
33 12.33 IFNG IL6 TLR10 TLR9 TNF
34 12.32 CXCL8 IL1A IL1B IL6 TNF
35
Show member pathways
12.28 IFNG IL1A IL1B TNF
36
Show member pathways
12.24 IFNG IL1B IL2 IL6 LTA TLR10
37
Show member pathways
12.22 CXCL8 IFNG IL1A IL1B IL2 IL4
38
Show member pathways
12.22 CXCL8 IFNG IL1B IL4 IL6 TLR9
39
Show member pathways
12.19 IL1A IL1B IL2 TLR10 TLR9
40 12.18 IFNG IL1A IL1B TNF
41 12.14 IFNG IL1A IL1B TNF
42 12.13 CD79A IFNG IL2 IL4 IL6 TNF
43 12.12 CXCL8 IL1A IL1B IL4 IL6 TNF
44 12.11 CXCL8 IFNG IL1A IL1B IL6
45
Show member pathways
12.08 IFNG IL1B IL2 IL4
46 12.08 CXCL8 IL1A IL1B IL6 TNF
47 12.07 IL1A IL1B IL4 IL6 TNF
48 12.06 IL1B IL6 LTA TNF
49 12.06 CXCL8 IFNG IL1B IL6 TNF
50 12 CXCL8 IL1B LTA TNF

GO Terms for Tonsillitis

Cellular components related to Tonsillitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CXCL8 DEFB1 IFNG IL1A IL1B IL2
2 extracellular space GO:0005615 9.4 CXCL8 DEFB1 IFNG IL1A IL1B IL2

Biological processes related to Tonsillitis according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.95 IFNG IL1A IL1B IL6 TLR9 TNF
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 IL1A IL1B TLR9 TNF
3 positive regulation of protein phosphorylation GO:0001934 9.92 IFNG IL1B IL2 TNF
4 inflammatory response GO:0006954 9.91 CXCL8 IL1A IL1B IL6 TLR10 TLR9
5 activation of MAPK activity GO:0000187 9.89 IL1B SOD1 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 IL1B IL6 TLR9 TNF
7 positive regulation of DNA binding transcription factor activity GO:0051091 9.88 IL1B IL6 TNF
8 defense response to Gram-negative bacterium GO:0050829 9.85 DEFB1 IL6 TLR9
9 positive regulation of inflammatory response GO:0050729 9.85 IL2 TLR10 TLR9
10 regulation of insulin secretion GO:0050796 9.84 IFNG IL1B TNF
11 defense response to Gram-positive bacterium GO:0050830 9.84 DEFB1 IL6 LTA TNF
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 IFNG IL2 IL6
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 IL1B TLR9 TNF
14 positive regulation of JNK cascade GO:0046330 9.8 IL1A IL1B TLR9 TNF
15 cytokine-mediated signaling pathway GO:0019221 9.8 CXCL8 IL1A IL1B IL2 IL4 IL6
16 positive regulation of B cell proliferation GO:0030890 9.79 IL2 IL4 TLR9
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.78 IFNG IL1B TNF
18 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.77 IL1A IL1B TNF
19 positive regulation of T cell proliferation GO:0042102 9.76 IL1B IL2 IL4 IL6
20 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.75 IL1A IL1B IL2
21 humoral immune response GO:0006959 9.73 IFNG IL6 LTA TNF
22 positive regulation of T cell differentiation GO:0045582 9.72 IL2 IL4
23 embryonic digestive tract development GO:0048566 9.72 CXCL8 TNF
24 positive regulation of interleukin-8 production GO:0032757 9.72 IL1B TLR9 TNF
25 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
26 regulation of regulatory T cell differentiation GO:0045589 9.71 IFNG IL2
27 response to copper ion GO:0046688 9.71 IL1A SOD1
28 positive regulation of interferon-gamma production GO:0032729 9.71 IL1B IL2 LTA TNF
29 negative regulation of growth of symbiont in host GO:0044130 9.7 LTA TNF
30 response to molecule of bacterial origin GO:0002237 9.7 CXCL8 TLR9
31 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.7 IL1A IL1B
32 positive regulation of chemokine production GO:0032722 9.7 IL6 TLR9 TNF
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL1B TNF
34 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.69 IL1A IL1B
35 positive regulation of immunoglobulin secretion GO:0051024 9.69 IL2 IL6
36 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IFNG IL1B TNF
37 regulation of cytokine secretion GO:0050707 9.68 TLR10 TLR9
38 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.68 IL1B TLR9
39 negative regulation of lipid storage GO:0010888 9.68 IL6 TNF
40 positive regulation of isotype switching to IgG isotypes GO:0048304 9.67 IL2 IL4
41 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IL1B TNF
42 ectopic germ cell programmed cell death GO:0035234 9.66 IL1A IL1B
43 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
44 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
45 fever generation GO:0001660 9.64 IL1A IL1B
46 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.63 LTA TNF
47 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
48 regulation of signaling receptor activity GO:0010469 9.61 CXCL8 IFNG IL1A IL1B IL2 IL4
49 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.57 LTA TNF
50 positive regulation of vitamin D biosynthetic process GO:0060557 9.56 IFNG TNF

Molecular functions related to Tonsillitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CXCL8 IFNG IL1A IL1B IL2 IL4
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B TLR9
3 protein binding GO:0005515 10 CD79A CXCL8 DEFB1 IFNG IL1A IL1B

Sources for Tonsillitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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