MCID: TNS005
MIFTS: 61

Tonsillitis

Categories: Immune diseases, Infectious diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Tonsillitis

MalaCards integrated aliases for Tonsillitis:

Name: Tonsillitis 12 56 44 45 15 74 64
Chronic Tonsillitis 12 56 74
Throat Infection - Tonsillitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10456
ICD9CM 36 474.00
MeSH 45 D014069
NCIt 51 C116006
SNOMED-CT 69 90176007 90979004
ICD10 34 J35.0 J35.01

Summaries for Tonsillitis

MedlinePlus : 44 What are tonsils? Tonsils are lumps of tissue at the back of the throat. There are two of them, one on each side. Along with the adenoids, tonsils are part of the lymphatic system. The lymphatic system clears away infection and keeps body fluids in balance. Tonsils and adenoids work by trapping the germs coming in through the mouth and nose. What is tonsillitis? Tonsillitis is an inflammation (swelling) of the tonsils. Sometimes along with tonsillitis, the adenoids are also swollen. What causes tonsillitis? The cause of tonsillitis is usually a viral infection. Bacterial infections such as strep throat can also cause tonsillitis. Who is at risk for tonsillitis? Tonsillitis is most common in children over age two. Almost every child in the United States gets it at least once. Tonsillitis caused by bacteria is more common in kids ages 5-15. Tonsillitis caused by a virus is more common in younger children. Adults can get tonsillitis, but it is not very common. Is tonsillitis contagious? Although tonsillitis is not contagious, the viruses and bacteria that cause it are contagious. Frequent handwashing can help prevent spreading or catching the infections. What are the symptoms of tonsillitis? The symptoms of tonsillitis include A sore throat, which may be severe Red, swollen tonsils Trouble swallowing A white or yellow coating on the tonsils Swollen glands in the neck Fever Bad breath When should I get medical help for my child? You should call your health care provider if your child Has a sore throat for more than two days Has trouble or pain when swallowing Feels very sick or very weak You should get emergency care right away if your child Has trouble breathing Starts drooling Has a lot of trouble swallowing How is tonsillitis diagnosed? To diagnose tonsillitis, your child's health care provider will first ask you about your child's symptoms and medical history. The provider will look at your child's throat and neck, checking for things such as redness or white spots on the tonsils and swollen lymph nodes. Your child will probably also have one or more tests to check for strep throat, since it can cause tonsillitis and it requires treatment. It could be a rapid strep test, a throat culture, or both. For both tests, the provider uses a cotton swab to collect a sample of fluids from your child's tonsils and the back of the throat. With the rapid strep test, testing is done in the office, and you get the results within minutes. The throat culture is done in a lab, and it usually takes a few days to get the results. The throat culture is a more reliable test. So sometimes if the rapid strep test is negative (meaning that it does not show any strep bacteria), the provider will also do a throat culture just to make sure that your child does not have strep. What are the treatments for tonsillitis? Treatment for tonsillitis depends on the cause. If the cause is a virus, there is no medicine to treat it. If the cause is a bacterial infection, such as strep throat, your child will need to take antibiotics. It is important for your child to finish the antibiotics even if he or she feels better. If treatment stops too soon, some bacteria may survive and re-infect your child. No matter what is causing the tonsillitis, there are some things you can do to help your child feel better. Make sure that your child Gets a lot of rest Drinks plenty of fluids Tries eating soft foods if it hurts to swallow Tries eating warm liquids or cold foods like popsicles to soothe the throat Isn't around cigarette smoke or do anything else that could irritate the throat Sleeps in a room with a humidifier Gargles with saltwater Sucks on a lozenge (but do not give them to children under four; they can choke on them) Takes an over-the-counter pain reliever such as acetaminophen. Children and teenagers should not take aspirin. In some cases, your child may need a tonsillectomy. What is a tonsillectomy and why might my child need one? A tonsillectomy is surgery to remove the tonsils. Your child might need it if he or she Keeps getting tonsillitis Has bacterial tonsillitis that does not get better with antibiotics Has tonsils are too big, and are causing trouble breathing or swallowing Your child usually gets the surgery and goes home later that day. Very young children and people who have complications may need to stay in the hospital overnight. It can take a week or two before your child completely recovers from the surgery.

MalaCards based summary : Tonsillitis, also known as chronic tonsillitis, is related to rheumatic fever and sleep apnea, and has symptoms including sore throat An important gene associated with Tonsillitis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Cedax and Sufentanil have been mentioned in the context of this disorder. Affiliated tissues include tonsil, testes and lymph node, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

PubMed Health : 64 About tonsillitis: Sore throats can have a range of causes. Common cold viruses are usually to blame. In rarer cases, sore throats are caused by an infection of the tonsils (tonsillitis). This infection is often bacterial, or sometimes viral. But it isn’t easy to tell what kind of germs are responsible for the infection. Children and teenagers are much more susceptible to tonsillitis than adults are.Acute tonsillitis starts suddenly and usually goes away again within one to two weeks. But tonsillitis can return several times over the course of a year and may become chronic. In chronic tonsillitis, the bacteria become permanently settled in the tonsils, which are always slightly inflamed as a result. People who have chronic tonsillitis might keep getting acute infections with more severe symptoms too. Having chronic tonsillitis can be a real problem, and may also lead to complications in rare cases.

Wikipedia : 77 Tonsillitis is inflammation of the tonsils, typically of rapid onset. It is a type of pharyngitis.... more...

Related Diseases for Tonsillitis

Diseases related to Tonsillitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 642)
# Related Disease Score Top Affiliating Genes
1 rheumatic fever 31.8 IL10 IL2 IL6 TNF
2 sleep apnea 31.5 CXCL8 IL1B IL6 TNF
3 extramedullary plasmacytoma 30.3 IL2 IL6
4 haemophilus influenzae 30.1 CXCL8 IL1B TNF
5 rhinitis 30.1 CXCL8 IL4 TLR9
6 reactive arthritis 30.1 IFNG IL10 TNF
7 candidiasis 29.9 DEFB4A IFNG IL10
8 leukemia, chronic lymphocytic 29.9 IL1A IL2 IL4 TLR9
9 allergic rhinitis 29.8 CXCL8 IFNG IL10 IL4
10 respiratory allergy 29.8 IL10 IL4 TLR9
11 plasmacytoma 29.8 CD79A IL2 IL6
12 glomerulonephritis 29.7 CD79A IL1B TLR9
13 poliomyelitis 29.7 IFNG IL10 IL4 TNF
14 laryngitis 29.7 IL1B IL6 TNF
15 crohn's disease 29.7 IL10 TLR9 TNF
16 fasciitis 29.6 CXCL8 IL6 TNF
17 measles 29.6 IFNG IL2 IL4 IL6
18 alopecia areata 29.5 IFNG IL1A IL2 TNF
19 rheumatic heart disease 29.5 IL10 IL4 IL6 TNF
20 kawasaki disease 29.5 IL10 IL6 TNF
21 gingival disease 29.5 IL1A IL1B IL6
22 lymphadenitis 29.4 CXCL8 IFNG IL10 IL1B TNF
23 septic arthritis 29.4 CXCL8 DEFB4A TLR9
24 necrotizing fasciitis 29.3 CXCL8 IL2 IL6 LTA
25 sudden infant death syndrome 29.2 IL10 IL1B IL6 TNF
26 hemophagocytic lymphohistiocytosis 29.2 CXCL8 IFNG IL10 TNF
27 osteoporosis 29.1 IFNG IL1A IL1B IL6 TNF
28 human immunodeficiency virus infectious disease 29.0 IFNG IL10 IL2 IL6 TLR9 TNF
29 heart disease 29.0 CXCL8 IL10 IL1B IL6 TNF
30 conjunctivitis 29.0 CXCL8 IFNG IL2 IL4 IL6
31 endocarditis 28.9 CXCL8 IL10 IL6 TNF
32 post-transplant lymphoproliferative disease 28.9 IL10 IL1A IL6 LTA TNF
33 typhoid fever 28.9 IFNG IL1B IL6 LTA TNF
34 aphthous stomatitis 28.9 IL10 IL1B IL2 IL4 IL6 TNF
35 pertussis 28.9 IL10 IL1A IL1B IL6 TNF
36 psoriatic arthritis 28.8 IL1A IL1B IL6 LTA TNF
37 purpura 28.8 CD79A IL6 TNF
38 orofacial granulomatosis 28.8 CD79A IFNG IL10 IL4 TNF
39 arthritis 28.8 CXCL8 IFNG IL10 IL1A IL1B IL6
40 leishmaniasis 28.8 IFNG IL10 IL1A IL1B IL4 TLR9
41 mouth disease 28.7 IFNG IL10 IL1B IL6 TLR9 TNF
42 otitis media 28.7 CD79A CXCL8 IL10 IL1B IL4 IL6
43 pneumonia 28.7 CXCL8 IL10 IL1B IL6 TLR9 TNF
44 tetanus 28.7 CD79A IFNG IL10 IL2 IL4 LTA
45 human immunodeficiency virus type 1 28.7 IFNG IL10 IL2 IL6 LTA TNF
46 appendicitis 28.7 CXCL8 IL10 IL1B IL6 TNF
47 meningitis 28.5 CXCL8 IFNG IL10 IL1B IL6 TLR9
48 bacterial meningitis 28.5 CXCL8 IL10 IL1B IL6 TLR9 TNF
49 gastroenteritis 28.4 CXCL8 IL10 IL1B IL4 IL6 TNF
50 ulcerative colitis 28.2 CXCL8 IFNG IL10 IL1B IL2 IL6

Graphical network of the top 20 diseases related to Tonsillitis:



Diseases related to Tonsillitis

Symptoms & Phenotypes for Tonsillitis

UMLS symptoms related to Tonsillitis:


sore throat

GenomeRNAi Phenotypes related to Tonsillitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.83 CXCL8 IL10 IL1A IL1B IL2 LTA
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.83 CXCL8 IL10 IL1A IL1B IL2 LTA

MGI Mouse Phenotypes related to Tonsillitis:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.26 CD79A IFNG IL10 IL1A IL1B IL2
2 homeostasis/metabolism MP:0005376 10.23 CD79A IFNG IL10 IL1A IL1B IL2
3 immune system MP:0005387 10.21 CD79A IFNG IL10 IL1A IL1B IL2
4 cardiovascular system MP:0005385 10.19 IFNG IL10 IL1A IL1B IL2 IL6
5 cellular MP:0005384 10.18 CD79A IFNG IL10 IL2 IL4 IL6
6 endocrine/exocrine gland MP:0005379 10.1 IFNG IL10 IL2 IL4 IL6 LTA
7 digestive/alimentary MP:0005381 10.05 IFNG IL10 IL2 IL4 IL6 TLR9
8 liver/biliary system MP:0005370 10.02 CD79A IFNG IL10 IL2 IL4 IL6
9 integument MP:0010771 10.01 IFNG IL10 IL1A IL1B IL4 IL6
10 neoplasm MP:0002006 9.97 CD79A IFNG IL10 IL1A IL1B IL2
11 nervous system MP:0003631 9.91 CD79A IFNG IL10 IL1B IL4 IL6
12 respiratory system MP:0005388 9.7 IFNG IL10 IL2 IL4 IL6 LTA
13 skeleton MP:0005390 9.56 IFNG IL10 IL1B IL4 IL6 LTA
14 vision/eye MP:0005391 9.23 IFNG IL10 IL2 IL4 IL6 LTA

Drugs & Therapeutics for Tonsillitis

PubMedHealth treatment related to Tonsillitis: 64

The main goal of treatment is to relieve symptoms and prevent complications. The following medicines can be used to treat acute tonsillitis:Medication for relieving pain and lowering fever, like ibuprofen or acetaminophen (paracetamol)Antibiotics (for bacterial tonsillitis only)Antibiotics can make the tonsillitis go away a little sooner. They can also lower the risk of developing complications. But they have side effects too.Some people relieve their symptoms by sucking on throat lozenges, or using home remedies such as a neck wrap or gargling with salt water or tea.Recurrent tonsillitis can also be treated with painkillers or antibiotics. The surgical removal of tonsils is a treatment option for people who frequently get tonsillitis.

FDA approved drugs:

# Drug Name Active Ingredient(s) 19 Company Approval Date
1
Cedax 19 CEFTIBUTEN DIHYDRATE Schering-Plough December 1995

Drugs for Tonsillitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 198)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
2
Acetaminophen Approved Phase 4,Phase 2,Not Applicable 103-90-2 1983
3
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
4
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 26787-78-0 33613
5
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 447043
6
Penicillin V Approved, Vet_approved Phase 4,Phase 3,Not Applicable 87-08-1 6869
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2 1177-87-3
9
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
10
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
11
Codeine Approved, Illicit Phase 4 76-57-3 5284371
12
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
13
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
14
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
15
Clarithromycin Approved Phase 4,Phase 1 81103-11-9 84029
16
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560 441411
17
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 23925 27284
18
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
19
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
20
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
21
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
22
Racepinephrine Approved Phase 4 329-65-7 838
23
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
24
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
25
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
26
Ibuprofen Approved Phase 4 15687-27-1 3672
27
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
28 Andrographolide Investigational Phase 4 5508-58-7
29 Tinoridine Investigational Phase 4 24237-54-5
30
Propyl Gallate Investigational Phase 4 121-79-9 4947
31 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
32 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Antiviral Agents Phase 4
34 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Not Applicable
35 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Not Applicable
36 Antiparasitic Agents Phase 4,Not Applicable
37 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
38 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
39 Antiprotozoal Agents Phase 4,Not Applicable
40 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Not Applicable
41 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Not Applicable
42 Andrographis Phase 4
43 Anesthetics, General Phase 4,Phase 2,Not Applicable
44 Adjuvants, Anesthesia Phase 4,Phase 2,Not Applicable
45 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
46 Anesthetics, Intravenous Phase 4,Phase 2,Not Applicable
47 Narcotics Phase 4,Phase 2,Not Applicable
48 Analgesics, Opioid Phase 4,Phase 2,Not Applicable
49 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
50 Anesthetics, Local Phase 4,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 107)
# Name Status NCT ID Phase Drugs
1 Evaluate the Efficacy and Safety of Andrographolide Sulfonate in Patients With Acute Tonsillitis Unknown status NCT03134443 Phase 4 Andrographolide sulfonate;Andrographolide sulfonate simulation
2 Randomized Controlled Study of Plasmaknife Tonsillectomy Versus Monopolar Tonsillectomy Unknown status NCT00466544 Phase 4
3 Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Tonsillectomy or Adeno-tonsillectomy in Children Unknown status NCT02205580 Phase 4 continuous intravenous sufentanil 0.02μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.03μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.04μg•kg-1•h-1 infusion
4 Multicenter, Open, Randomized Comparative Trial To Compare The Efficacy Of Azithromycin Versus Amoxicillin In Children With Strep Throat Completed NCT00643539 Phase 4 Zithromax;Clamoxyl
5 Efficacy of Tinoridine in Treating Pain and Inflammation in Adults Completed NCT01224756 Phase 4 Tinoridine HCl;Placebo
6 Study of 5 and 10 Days Treatment With Penicillin Against Sore Throat Caused by Streptococci Completed NCT02712307 Phase 4 Phenoxymethylpenicillin
7 Dexmedetomidine for Immediate Perioperative Analgesia in Pediatric Patients Undergoing Tonsillectomy Completed NCT00654511 Phase 4 Fentanyl;Fentanyl;Dexmedetomidine;Dexmedetomidine
8 A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy Completed NCT01267136 Phase 4 Codeine with acetaminophen;Tramadol suspension
9 Acetaminophen's Efficacy For Post-operative Pain Completed NCT01721486 Phase 4 IV acetaminophen;PO acetaminophen
10 Recurrent Throat Infections and Tonsillectomy Completed NCT00547391 Phase 4
11 EXPAREL® for Pain After Tonsillectomy Completed NCT02444533 Phase 4 Liposomal Bupivacaine
12 Placebo and Active Controlled Study to Compare the Efficacy of Aspirin and Paracetamol in Treatment of Sore Throat Associated With a Common Cold Completed NCT01465009 Phase 4 Acetylsalicylic acid (Aspirin, BAYE4465);Paracetamol;Placebo
13 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
14 DIAMANTE - Diseases Infectious Analysis Microflora Antibiotic Effect Completed NCT00424905 Phase 4 Bacillus clausii
15 Clinical Trial for the Assessment of Delayed Antibiotic Treatment Strategies Completed NCT01363531 Phase 4
16 the Effectiveness of Lactoferrin in Treatment of Iron Deficiency Anemia in Children With Chronic Tonsillitis Recruiting NCT03748043 Phase 4 Lactoferrin;Ferric Hydroxide Polymaltose
17 Perioperative Tonsillectomy Protocol Development Recruiting NCT03323047 Phase 4 Acetaminophen;Low-dose Dexamethasone;Placebo Oral Tablet;High-Dose Dexamethasone
18 Comparison of Bizact With Electroscissor for Tonsillectomy Recruiting NCT03854279 Phase 4
19 Gabapentin Premedication to Reduce Postoperative Pain for Pediatric Tonsillectomy Recruiting NCT03625011 Phase 4 Gabapentin
20 Post-tonsillectomy Pain Control in Adults Recruiting NCT02358850 Phase 4 Norco (Hydrocodone and Acetaminophen);Percocet (Oxycodone and Acetaminophen);Dilaudid (hydromorphone);Tylenol (Acetaminophen)
21 EXPAREL Post-tonsillectomy Clinical Trial Recruiting NCT03420638 Phase 4 Adjunct Exparel (bupivacaine liposome suspension 1.3%)
22 Registration of the Study of Reyanning Mixture Not yet recruiting NCT03704506 Phase 4 Reyanning mixture;amoxil capsule;Reyanning mixture simulator;amoxil capsule simulator
23 Effect of OM-85 on Respiratory Tract Infections and Adenoid Tissue in Children With Adenoid Hypertrophy Not yet recruiting NCT03243565 Phase 4
24 Evaluation of Inflammatory Symptoms Reduction With Amoxicillin + Ketoprofen in Acute Pharyngeal Tonsillitis in Pediatric Patients Terminated NCT00799838 Phase 4 Ketoprofen;Placebo (for Ketoprofen);Amoxicillin
25 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Terminated NCT02162433 Phase 4 Normal Saline;Dexmedetomidine
26 Post-operative Pain Control After Pediatric Adenotonsillectomy Terminated NCT02296840 Phase 4 Ibuprofen;Hydrocodone-Acetaminophen
27 Lactobacillus Reuteri DSM 17938 and Prevention of Respiratory and Gastrointestinal Infections in Mexican Infants Unknown status NCT01249911 Phase 3
28 Efficacy Study of Pristinamycin Versus Amoxicillin to Treat Tonsillitis Induced by Streptococcus in Children Completed NCT00393744 Phase 3 pristinamycin;amoxicillin
29 A Trial Of Azithromycin SR For The Treatment Of Laryngopharyngitis or Tonsillitis or Acute Bacterial Rhinosinusitis Completed NCT00393835 Phase 3 Azithromycin SR
30 A Multicenter, Randomized, Double-Blind, Double-Dummy Study Of Azithromycin SR Versus Amoxicillin For The Treatment Of Strep Throat In Children Completed NCT00643149 Phase 3 amoxicillin;azithromycin SR
31 A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial of Azithromycin Sustained Release Versus 3-Day Azithromycin for the Treatment of Strep Throat in Adolescents and Adults Completed NCT00644293 Phase 3 azithromycin (Zithromax);placebo;azithromycin SR;placebo
32 APC-111 Once a Day (QD) for 7 Days vs. Penicillin Taken Four Times a Day (QID) for 10 Days in Patients With Strep Throat Completed NCT00095368 Phase 3 Amoxicillin Pulsatile Release Multiparticulate Tablet (drug)
33 APC-111 MP Tablet Once a Day vs.Penicillin VK Four Times a Day Both for 10 Days in Patients With Strep Throat Completed NCT00242281 Phase 3 APC-111 MP Tablet, 775 mg
34 Active and Placebo Controlled Study to Test the Efficacy and Safety of an Aspirin-Lidocaine Lozenge in the Symptomatic Treatment of Sore Throat Associated With a Common Cold Completed NCT01361399 Phase 3 Acetylsalicylic acid (Aspirin, BAYE4465) & Lidocain;Acetylsalicylic Acid (Aspirin, BAYE4465);Lidocain;Placebo
35 A Long-Term Extension Study of RoActemra/Actemra (Tocilizumab) in Patients With Juvenile Idiopathic Arthritis From France Who Completed WA19977 Core Study Completed NCT01673919 Phase 3 tocilizumab [RoActemra/Actemra]
36 CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study Completed NCT01948856 Phase 3 J022X ST;Placebo
37 Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial Completed NCT01304927 Phase 2, Phase 3 Cholecalciferol and calcium
38 E. Coli Nissle 1917 - Suspension for Infection Prophylaxis Active, not recruiting NCT02802059 Phase 3 EcN-Suspension;Placebo
39 TELI TON - Telithromycin in Tonsillitis Terminated NCT00315042 Phase 3 Telithromycin (HMR3647);Penicillin
40 TELI TAD - Telithromycin in Tonsillitis in Adolescents and Adults Terminated NCT00315549 Phase 3 Telithromycin;Penicillin
41 Comparison of Floseal Hemostasis Tonsillectomy With Coblation Tonsillectomy and Cautery Hemostasis Tonsillectomy Withdrawn NCT00459927 Phase 2, Phase 3
42 Evaluation of Coblation Channeling in Treating Chronic Tonsillitis Unknown status NCT01193790 Phase 2
43 A Phase I/II to Assess Safety, Tolerability and Efficacy of DL-lactic Acid Syrup in Children With Recurrent Tonsillitis Completed NCT01988558 Phase 1, Phase 2 DL - Lactic Acid
44 Treatment of Acute Pharyngo-Tonsillitis With Essential Oils of Aromatic Plants Completed NCT00610519 Phase 1, Phase 2
45 Efficacy and Safety of Meloxicam vs. Naproxen Sodium in Patients With Acute Non Bacterial Pharyngitis or Pharyngo-tonsillitis Completed NCT02183038 Phase 2 Meloxicam low;Meloxicam high;Naproxen sodium;Meloxicam placebo low;Meloxicam placebo high;Naproxen sodium placebo
46 Celecoxib as a Post-tonsillectomy Pain Medication Completed NCT00583453 Phase 2 Celecoxib;Placebo
47 Analgesic Effect of IV Acetaminophen in Tonsillectomies Completed NCT01691690 Phase 2 Acetaminophen (paracetamol);Normal Saline Flush;Midazolam;Sevoflurane;Nitrous Oxide/Oxygen;Propofol;Morphine;Ondansetron;Dexamethasone
48 PASS Study To Evaluate The Potential Of Zithromax To Cause Ocular Problems In Pediatric Patients Terminated NCT01919996 Phase 2 Azithromycin
49 Evaluate Effects of Multiple Doses of Rifampin and Clarithromycin on the Single Dose Pharmacokinetics of Deflazacort Completed NCT02286635 Phase 1 Deflazacort and rifampin;Deflazacort and Clarithromycin
50 Controlled Human Infection for Vaccination Against Streptococcus Pyogenes Recruiting NCT03361163 Phase 1

Search NIH Clinical Center for Tonsillitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: tonsillitis

Genetic Tests for Tonsillitis

Anatomical Context for Tonsillitis

MalaCards organs/tissues related to Tonsillitis:

42
Tonsil, Testes, Lymph Node, Neutrophil, Bone, Colon, T Cells

Publications for Tonsillitis

Articles related to Tonsillitis:

(show top 50) (show all 865)
# Title Authors Year
1
Fusobacterium necrophorum sepsis after tonsillitis/pharyngitis. ( 30700448 )
2019
2
Case Report: Gonorrhea as a Cause of Exudative Tonsillitis. ( 30633488 )
2019
3
Grisel's syndrome associated with tonsillitis. ( 30656135 )
2019
4
Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells. ( 30728285 )
2019
5
Intramural oesophageal abscess: an unusual complication of tonsillitis. ( 30733246 )
2019
6
Glutathione S-transferase enzyme activity and protein expression in patients with recurrent tonsillitis and idiopathic tonsillar hypertrophy. ( 30765895 )
2019
7
Mucosal bacterial immunotherapy with MV130 highly reduces the need of tonsillectomy in adults with recurrent tonsillitis. ( 30779677 )
2019
8
Staphylococcus aureus in tonsils of patients with recurrent tonsillitis: prevalence, susceptibility profile, and genotypic characterization. ( 30849330 )
2019
9
Tonsillar hyperplasia and recurrent acute tonsillitis in children: Immunohistochemical evaluation of the lymphatic tissue. ( 30851510 )
2019
10
Long-term outcomes of tonsillectomy for recurrent tonsillitis in adults. ( 30908668 )
2019
11
Antibiotics for recurrent acute pharyngo-tonsillitis: systematic review. ( 29651614 )
2018
12
Use of Streptococcus salivarius K12 to reduce the incidence pharyngo-tonsillitis and acute otitis media in children: a retrospective analysis in not-recurrent pediatric subjects. ( 29322750 )
2018
13
Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis. ( 29942488 )
2018
14
Psoriasis, chronic tonsillitis, and biofilms: Tonsillar pathologic findings supporting a microbial hypothesis. ( 29554401 )
2018
15
Tonsillitis exacerbates renal injury in IgA nephropathy through promoting Th22 cells chemotaxis. ( 29549623 )
2018
16
Diagnostic role of mean platelet volume in tonsillitis with and without peritonsillar abscess. ( 29888695 )
2018
17
LipschA1tz ulcer and group A streptococcal tonsillitis. ( 29880620 )
2018
18
Is Scottish Intercollegiate Guidelines Network guidance for GP management of tonsillitis suitable? A qualitative study. ( 29590327 )
2018
19
Assessment of Volatile Sulfur Compounds in Adult and Pediatric Chronic Tonsillitis Patients Receiving Tonsillectomy. ( 29719951 )
2018
20
Detection of GSK-3I^ activation index in pediatric chronic tonsillitis is an indicator for chronic recurrent inflammation. ( 29530430 )
2018
21
A Taiwanese population-based study on the association between chronic tonsillitis and tonsil cancer. ( 29484140 )
2018
22
A Man With Tonsillitis and Hepatitis. ( 30265322 )
2018
23
An Instrument for Rating Quality of Life Related to Sore Throat in Patients Suffering from Acute Pharyngitis or Tonsillitis. ( 30429687 )
2018
24
The Psoriasis Risk Allele HLA-C*06:02 Shows Evidence of Association with Chronic or Recurrent Streptococcal Tonsillitis. ( 30037793 )
2018
25
Association between Ca/Mg/P status and suppurative tonsillitis in children. ( 30043571 )
2018
26
DYNAMICS OF CONTENT OF SOME MINERALS IN TEENAGERS WITH CARDIOVASCULAR SYSTEM PATHOLOGY AGAINST THE BACKGROUND OF CHRONIC TONSILLITIS ZMIANY ZAWARTOŚCI NIEKTÓRYCH SKŁADNIKÓW MINERALNYCH U MŁODZIEŻY Z CHOROBAMI UKŁADU SERCOWO-NACZYNIOWEGO JAKO PODŁOŻE ROZWOJU PRZEWLEKŁEGO ZAPALENIA MIGDAŁKÓW PODNIEBIENNYCH. ( 30099424 )
2018
27
Assessing the Quality of the Management of Tonsillitis among Australian Children: A Population-Based Sample Survey. ( 30149777 )
2018
28
The bacterial community and local lymphocyte response are markedly different in patients with recurrent tonsillitis compared to obstructive sleep apnoea. ( 30174001 )
2018
29
Chronic tonsillitis and biofilms: a brief overview of treatment modalities. ( 30233227 )
2018
30
Erratum: Chronic tonsillitis and biofilms: a brief overview of treatment modalities [Corrigendum]. ( 30319282 )
2018
31
THERMOSEMIOTICS OF ACUTE TONSILLITIS. ( 30358537 )
2018
32
Microbiological Profile of Chronic Tonsillitis in the Pediatric Age Group. ( 30473976 )
2018
33
A randomized, open-label, multicenter, comparative study of therapeutic efficacy, safety and tolerability of BNO 1030 extract, containing Althea root, Cammomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb in the treatment of acute non-bacterial tonsillitis in children aged 6 to 18 years. ( 30554882 )
2018
34
The differences in the expression of fractalkine and its receptor in conditions of tonsillar hypertrophy and chronic tonsillitis. ( 30554983 )
2018
35
Treatment Challenges of Group A Beta-hemolytic Streptococcal Pharyngo-Tonsillitis. ( 28680500 )
2017
36
Staphylococcus aureus isolated from tonsillectomized adult patients with recurrent tonsillitis. ( 27862322 )
2017
37
A white man with Kikuchi-Fujimoto disease mimicking lymphoma, preceded by frequent episodes of tonsillitis: a case report. ( 28189144 )
2017
38
Is tonsillectomy recommended in adults with recurrent tonsillitis? ( 28408369 )
2017
39
Amoxicillin and clavulanate potassium in treating children with suppurative tonsillitis. ( 28952295 )
2017
40
Management of recurrent tonsillitis in children. ( 28385329 )
2017
41
Measles: A missed cause of acute tonsillitis. ( 29121387 )
2017
42
A comparison of tonsillar surface swabbing, fine-needle aspiration core sampling, and dissected tonsillar core biopsy culture in children with recurrent tonsillitis. ( 28636739 )
2017
43
Correction: The carriage of interleukin-1B-31*C allele plus Staphylococcus aureus and Haemophilus influenzae increases the risk of recurrent tonsillitis in a Mexican population. ( 29023596 )
2017
44
The effect of tonsillectomy on the morbidity from recurrent tonsillitis. ( 28199053 )
2017
45
Inverse relationship between toxic shock syndrome toxin-1 antibodies and interferon-I^ and interleukin-6 in peripheral blood mononuclear cells from patients with pediatric tonsillitis caused by Staphylococcus aureus. ( 28483238 )
2017
46
The role of environmental tobacco exposure and Helicobacter pylori infection in the risk of chronic tonsillitis in children. ( 28380174 )
2017
47
The Impact of Tobacco Smoking Upon Chronic/Recurrent Tonsillitis and Post Tonsillectomy Bleeding. ( 28382125 )
2017
48
A Retrospective Cohort Study of Glossopharyngeal Nerve Taste in Children with Recurrent Acute Tonsillitis. ( 28045639 )
2017
49
The effect of tonsillotomy on chronic recurrent tonsillitis in children. ( 28471689 )
2017
50
Hyperplasia and the degree and activity of inflammation in chronic recurrent tonsillitis: a histopathological study. ( 28439693 )
2017

Variations for Tonsillitis

Expression for Tonsillitis

Search GEO for disease gene expression data for Tonsillitis.

Pathways for Tonsillitis

Pathways related to Tonsillitis according to GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 CD79A CXCL8 DEFB1 DEFB4A IFNG IL10
2
Show member pathways
13.89 CXCL8 IL10 IL1A IL1B IL2 IL4
3
Show member pathways
13.76 CXCL8 IFNG IL10 IL1A IL1B IL2
4
Show member pathways
13.65 CXCL8 IFNG IL10 IL1A IL1B IL2
5
Show member pathways
13.52 CXCL8 IL10 IL1A IL1B IL2 IL4
6
Show member pathways
13.47 CXCL8 IFNG IL10 IL1A IL1B IL2
7
Show member pathways
13.42 CXCL8 IL10 IL1A IL1B IL2 IL4
8
Show member pathways
13.32 CD79A IFNG IL1A IL1B IL2 IL4
9
Show member pathways
13.32 CXCL8 IFNG IL10 IL1B IL2 IL6
10
Show member pathways
12.99 CXCL8 IFNG IL10 IL1A IL1B IL2
11 12.89 CXCL8 IFNG IL2 IL4 IL6
12
Show member pathways
12.86 IL1A IL1B IL2 IL6 LTA TLR9
13
Show member pathways
12.84 IL2 IL4 IL6 LTA TNF
14
Show member pathways
12.82 CXCL8 IFNG IL1B IL6 TNF
15
Show member pathways
12.76 CD79A IFNG IL10 IL2 IL4 TNF
16
Show member pathways
12.76 IFNG IL10 IL1A IL1B IL2 IL4
17
Show member pathways
12.75 IFNG IL1A IL1B LTA TNF
18
Show member pathways
12.73 IFNG IL10 IL1B IL2 IL6 TNF
19 12.72 CD79A IFNG IL10 IL1B IL2 IL4
20
Show member pathways
12.69 IL1A IL1B LTA TLR9 TNF
21
Show member pathways
12.68 CXCL8 IFNG IL1A IL1B IL2 IL4
22
Show member pathways
12.59 IFNG IL10 IL1A IL1B IL2 IL4
23
Show member pathways
12.55 IFNG IL2 IL4 TNF
24
Show member pathways
12.53 IFNG IL1B IL2 IL4 IL6 SOD1
25
Show member pathways
12.52 CXCL8 DEFB4A IFNG IL1B IL4 IL6
26
Show member pathways
12.5 IFNG IL10 IL2 IL4 IL6
27
Show member pathways
12.48 CXCL8 IFNG IL1A IL1B IL6 TNF
28
Show member pathways
12.43 IFNG IL10 IL1A IL1B IL4 TNF
29 12.41 IL2 IL6 LTA TNF
30
Show member pathways
12.41 CXCL8 IL1A IL6 TLR9 TNF
31 12.41 IFNG IL10 IL1A IL1B IL6 TLR9
32
Show member pathways
12.39 IL10 IL1B IL2 IL6 TLR9 TNF
33
Show member pathways
12.37 CXCL8 IL1A IL1B IL6 TNF
34 12.36 CXCL8 IL10 IL1A IL1B IL6 TNF
35
Show member pathways
12.33 CXCL8 DEFB4A IFNG IL1B IL4 IL6
36
Show member pathways
12.29 IFNG IL1A IL1B TNF
37 12.27 IFNG IL6 TLR9 TNF
38
Show member pathways
12.25 CXCL8 IFNG IL10 IL1A IL1B IL2
39
Show member pathways
12.24 IFNG IL1B IL4 IL6 SOD1 TNF
40 12.19 IFNG IL1A IL1B TNF
41 12.18 CD79A IFNG IL10 IL2 IL4 IL6
42 12.16 CXCL8 IL10 IL1A IL1B IL4 IL6
43 12.15 IFNG IL1A IL1B TNF
44
Show member pathways
12.13 IL1A IL1B IL2 TLR9
45 12.13 CXCL8 IFNG IL1A IL1B IL6
46
Show member pathways
12.12 IFNG IL10 IL1B IL2 IL6 LTA
47 12.1 CXCL8 IL1A IL1B IL6 TNF
48 12.1 CXCL8 IFNG IL10 IL1B IL6 TNF
49
Show member pathways
12.09 IFNG IL1B IL2 IL4
50 12.08 IL1B IL6 LTA TNF

GO Terms for Tonsillitis

Cellular components related to Tonsillitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 CXCL8 DEFB1 DEFB4A IFNG IL10 IL1A
2 extracellular region GO:0005576 9.47 CXCL8 DEFB1 DEFB4A IFNG IL10 IL1A

Biological processes related to Tonsillitis according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 IL1B IL6 TLR9 TNF
2 defense response GO:0006952 9.96 CXCL8 DEFB1 DEFB4A TNF
3 positive regulation of gene expression GO:0010628 9.95 IFNG IL1A IL1B IL4 IL6 TLR9
4 activation of MAPK activity GO:0000187 9.93 IL1B SOD1 TNF
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.93 IL10 IL1B IL6 TNF
6 response to drug GO:0042493 9.92 IL10 LTA SOD1
7 response to organic substance GO:0010033 9.92 IL10 SOD1 TNF
8 positive regulation of JNK cascade GO:0046330 9.91 IL1B TLR9 TNF
9 positive regulation of inflammatory response GO:0050729 9.91 IL2 TLR9 TNF
10 defense response to Gram-negative bacterium GO:0050829 9.91 DEFB1 DEFB4A IL6 TLR9
11 inflammatory response GO:0006954 9.91 CXCL8 IL10 IL1A IL1B IL6 TLR9
12 B cell differentiation GO:0030183 9.9 CD79A IL10 IL4
13 regulation of insulin secretion GO:0050796 9.9 IFNG IL1B TNF
14 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.9 CXCL8 DEFB1 DEFB4A
15 cellular response to lipopolysaccharide GO:0071222 9.89 CXCL8 IL10 IL1B IL6 TNF
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 IL1B TLR9 TNF
17 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 IFNG IL2 IL4 IL6
18 interleukin-12-mediated signaling pathway GO:0035722 9.87 IFNG IL10 SOD1
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.86 IFNG IL1B TNF
20 positive regulation of B cell proliferation GO:0030890 9.85 IL2 IL4 TLR9
21 positive regulation of T cell proliferation GO:0042102 9.84 IL1B IL2 IL4 IL6
22 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.83 IL1A IL1B TNF
23 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.83 IL1A IL1B IL2
24 negative regulation of interleukin-6 production GO:0032715 9.83 IL10 TLR9 TNF
25 positive regulation of interleukin-6 production GO:0032755 9.83 IL1B IL6 TLR9 TNF
26 defense response to Gram-positive bacterium GO:0050830 9.83 DEFB1 DEFB4A IL6 LTA TNF
27 positive regulation of cytokine secretion GO:0050715 9.81 IL10 IL1A TNF
28 positive regulation of interleukin-8 production GO:0032757 9.81 IL1B TLR9 TNF
29 humoral immune response GO:0006959 9.81 IFNG IL6 LTA TNF
30 negative regulation of neurogenesis GO:0050768 9.8 IL1B IL6 TNF
31 positive regulation of chemokine production GO:0032722 9.79 IL6 TLR9 TNF
32 positive regulation of interferon-gamma production GO:0032729 9.78 IL1B IL2 LTA TNF
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.77 IFNG IL1B TNF
34 negative regulation of growth of symbiont in host GO:0044130 9.77 IL10 LTA TNF
35 embryonic digestive tract development GO:0048566 9.76 CXCL8 TNF
36 negative regulation of lipid catabolic process GO:0050995 9.76 IL1B TNF
37 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.76 IL1B TNF
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.76 IL10 IL1B TNF
39 cytokine-mediated signaling pathway GO:0019221 9.76 CXCL8 IL10 IL1A IL1B IL2 IL4
40 response to copper ion GO:0046688 9.75 IL1A SOD1
41 response to ethanol GO:0045471 9.75 IL2 SOD1
42 regulation of regulatory T cell differentiation GO:0045589 9.75 IFNG IL2
43 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.75 IL1A IL1B
44 positive regulation of immunoglobulin secretion GO:0051024 9.74 IL2 IL6
45 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.74 IL1B TLR9
46 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.74 TLR9 TNF
47 positive regulation of isotype switching to IgG isotypes GO:0048304 9.74 IL2 IL4
48 negative regulation of lipid storage GO:0010888 9.73 IL6 TNF
49 endothelial cell apoptotic process GO:0072577 9.73 IL10 TNF
50 positive regulation of chemokine biosynthetic process GO:0045080 9.73 IL1B TNF

Molecular functions related to Tonsillitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 IL10 IL2 IL4 IL6
2 cytokine activity GO:0005125 9.32 CXCL8 IFNG IL10 IL1A IL1B IL2
3 CCR6 chemokine receptor binding GO:0031731 9.26 DEFB1 DEFB4A
4 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B TLR9

Sources for Tonsillitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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