MCID: TTH001
MIFTS: 32

Tooth Ankylosis

Categories: Bone diseases, Oral diseases

Aliases & Classifications for Tooth Ankylosis

MalaCards integrated aliases for Tooth Ankylosis:

Name: Tooth Ankylosis 12 44 15 73
Ankylosis of Teeth 12
Ankylosis of Tooth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12661
ICD10 33 K03.5
ICD9CM 35 521.6
MeSH 44 D020254
SNOMED-CT 68 14901003
UMLS 73 C0155930

Summaries for Tooth Ankylosis

MalaCards based summary : Tooth Ankylosis, also known as ankylosis of teeth, is related to permanent molars, secondary retention of and ankylosis, and has symptoms including toothache An important gene associated with Tooth Ankylosis is PTH1R (Parathyroid Hormone 1 Receptor), and among its related pathways/superpathways are Senescence and Autophagy in Cancer and Parathyroid hormone synthesis, secretion and action. Affiliated tissues include bone, and related phenotypes are craniofacial and hematopoietic system

Wikipedia : 76 Tooth ankylosis is the pathological fusing of cementum or dentine of a tooth root to the alveolar bone.... more...

Related Diseases for Tooth Ankylosis

Diseases related to Tooth Ankylosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 permanent molars, secondary retention of 11.2
2 ankylosis 10.5
3 osseous heteroplasia, progressive 10.0 BMP2 SPARC
4 brittle bone disorder 10.0 PTH1R SPARC
5 glucocorticoid-induced osteoporosis 10.0 BMP2 TNFSF11
6 ischemic bone disease 10.0 BMP2 TNFSF11
7 osteofibrous dysplasia 10.0 BMP2 SPARC
8 cleft lip 10.0
9 juxtacortical chondroma 10.0 PTH1R PTHLH
10 hypercalcemia, infantile, 1 10.0 PTH1R PTHLH
11 metaphyseal chondrodysplasia, jansen type 10.0 PTH1R PTHLH
12 endosteal hyperostosis, autosomal dominant 10.0 BMP2 TNFSF11
13 chondromyxoid fibroma 10.0 PTH1R PTHLH
14 bone resorption disease 9.9 BMP2 TNFSF11
15 enchondromatosis, multiple, ollier type 9.9 PTH1R PTHLH
16 chondrosarcoma 9.9 PTHLH SPARC
17 bone remodeling disease 9.9 BMP2 TNFSF11
18 pseudohypoparathyroidism, type ib 9.9 PTH1R PTHLH
19 pseudohypoparathyroidism 9.9 PTH1R PTHLH
20 osteonecrosis 9.9 BMP2 TNFSF11
21 hypoparathyroidism 9.9 PTH1R PTHLH
22 multicentric carpotarsal osteolysis syndrome 9.9 PTHLH TNFSF11
23 peripheral osteosarcoma 9.9 PTHLH SPARC
24 keratocystic odontogenic tumor 9.9 PTHLH TNFSF11
25 otosclerosis 9.9 BMP2 PTH1R
26 osteomyelitis 9.9 BMP2 TNFSF11
27 osteochondroma 9.9 BMP2 PTHLH
28 tooth resorption 9.9 BMP2 PTH1R TNFSF11
29 osteochondrodysplasia 9.9 PTH1R PTHLH
30 aortic valve disease 2 9.8 BMP2 SPARC TNFSF11
31 primary hyperparathyroidism 9.8 PTH1R PTHLH
32 clear cell chondrosarcoma 9.8 PTH1R PTHLH SPARC
33 chondroblastoma 9.8 PTH1R PTHLH TNFSF11
34 brachydactyly 9.6 BMP2 PTHLH
35 bone disease 9.6 PTH1R PTHLH SPARC TNFSF11
36 osteoporosis 9.4 BMP2 PTH1R PTHLH SPARC TNFSF11

Graphical network of the top 20 diseases related to Tooth Ankylosis:



Diseases related to Tooth Ankylosis

Symptoms & Phenotypes for Tooth Ankylosis

UMLS symptoms related to Tooth Ankylosis:


toothache

MGI Mouse Phenotypes related to Tooth Ankylosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.8 BMP2 PTH1R PTHLH SPARC TNFSF11
2 hematopoietic system MP:0005397 9.77 BMP2 PTH1R PTHLH SPARC TNFSF11
3 immune system MP:0005387 9.72 BMP2 PTH1R PTHLH SPARC TNFSF11
4 limbs/digits/tail MP:0005371 9.65 BMP2 PTH1R PTHLH SPARC TNFSF11
5 neoplasm MP:0002006 9.46 PTH1R PTHLH SPARC TNFSF11
6 skeleton MP:0005390 9.35 BMP2 PTH1R PTHLH SPARC TNFSF11
7 vision/eye MP:0005391 8.92 PTH1R PTHLH SPARC TNFSF11

Drugs & Therapeutics for Tooth Ankylosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ankylosed Teeth Treatment by Bone Orthodontic Treatment Unknown status NCT02337153

Search NIH Clinical Center for Tooth Ankylosis

Cochrane evidence based reviews: tooth ankylosis

Genetic Tests for Tooth Ankylosis

Anatomical Context for Tooth Ankylosis

MalaCards organs/tissues related to Tooth Ankylosis:

41
Bone

Publications for Tooth Ankylosis

Articles related to Tooth Ankylosis:

(show all 13)
# Title Authors Year
1
Diagnosis of tooth ankylosis using panoramic views, cone beam computed tomography, and histological data: a retrospective observational case series study. ( 29016762 )
2017
2
Stability of interceptive/corrective orthodontic treatment for tooth ankylosis and Class II mandibular deficiency: A case report with 10 years follow-up. ( 26275202 )
2015
3
Tooth ankylosis in deciduous teeth of children with cleft lip and/or palate. ( 16089265 )
2004
4
Primary tooth ankylosis: report of case with histological analysis. ( 7560370 )
1995
5
Treatment of multiple tooth ankylosis with removable prosthesis: case report. ( 8015956 )
1994
6
Ankylosis of teeth in the developing dentition. ( 3460109 )
1986
7
Experimental tooth ankylosis in the monkey. ( 6584053 )
1984
8
Tooth ankylosis. Clinical, radiographic and histological assessments. ( 6438004 )
1984
9
Experimental tooth ankylosis and horizontal tooth movement in the pig. ( 7025810 )
1981
10
Tooth ankylosis in man and the oxytalan fibre meshwork. ( 6940559 )
1980
11
Ankylosis of teeth following thermal injury. ( 4272008 )
1971
12
Measurement of space loss resulting from tooth ankylosis. ( 4879576 )
1968
13
Ankylosis of teeth. ( 5217081 )
1965

Variations for Tooth Ankylosis

Expression for Tooth Ankylosis

Search GEO for disease gene expression data for Tooth Ankylosis.

Pathways for Tooth Ankylosis

GO Terms for Tooth Ankylosis

Cellular components related to Tooth Ankylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 BMP2 PTHLH SPARC TNFSF11
2 intracellular GO:0005622 8.92 PTH1R SPARC TNFSF11 XPO1

Biological processes related to Tooth Ankylosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.67 BMP2 PTHLH TNFSF11
2 negative regulation of cell proliferation GO:0008285 9.65 BMP2 PTH1R PTHLH
3 animal organ morphogenesis GO:0009887 9.52 BMP2 TNFSF11
4 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.51 PTH1R PTHLH
5 cellular response to growth factor stimulus GO:0071363 9.46 BMP2 SPARC
6 bone development GO:0060348 9.43 SPARC TNFSF11
7 inner ear development GO:0048839 9.4 BMP2 SPARC
8 chondrocyte differentiation GO:0002062 9.37 BMP2 PTH1R
9 skeletal system development GO:0001501 9.33 BMP2 PTH1R PTHLH
10 bone resorption GO:0045453 9.32 PTH1R TNFSF11
11 osteoblast development GO:0002076 9.26 PTH1R PTHLH
12 bone mineralization GO:0030282 9.13 BMP2 PTH1R PTHLH
13 ossification GO:0001503 8.92 BMP2 PTH1R SPARC TNFSF11

Sources for Tooth Ankylosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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