MCID: TTH001
MIFTS: 32

Tooth Ankylosis

Categories: Oral diseases, Bone diseases

Aliases & Classifications for Tooth Ankylosis

MalaCards integrated aliases for Tooth Ankylosis:

Name: Tooth Ankylosis 12 44 15 73
Ankylosis of Teeth 12
Ankylosis of Tooth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12661
ICD10 33 K03.5
ICD9CM 35 521.6
MeSH 44 D020254
SNOMED-CT 68 14901003
UMLS 73 C0155930

Summaries for Tooth Ankylosis

MalaCards based summary : Tooth Ankylosis, also known as ankylosis of teeth, is related to permanent molars, secondary retention of and ankylosis, and has symptoms including toothache An important gene associated with Tooth Ankylosis is PTH1R (Parathyroid Hormone 1 Receptor), and among its related pathways/superpathways are Senescence and Autophagy in Cancer and Parathyroid hormone synthesis, secretion and action. Affiliated tissues include bone, and related phenotypes are craniofacial and limbs/digits/tail

Wikipedia : 76 Tooth ankylosis is the pathological fusing of cementum or dentine of a tooth root to the alveolar bone.... more...

Related Diseases for Tooth Ankylosis

Diseases related to Tooth Ankylosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 permanent molars, secondary retention of 11.0
2 ankylosis 10.3
3 prolapse of female genital organ 10.2 PVR SPARC
4 brittle bone disorder 10.1 PTH1R SPARC
5 osseous heteroplasia, progressive 10.1 BMP2 SPARC
6 osteofibrous dysplasia 10.0 BMP2 SPARC
7 glucocorticoid-induced osteoporosis 10.0 BMP2 TNFSF11
8 juxtacortical chondroma 10.0 PTH1R PTHLH
9 ischemic bone disease 10.0 BMP2 TNFSF11
10 hypercalcemia, infantile, 1 10.0 PTH1R PTHLH
11 pyle disease 10.0 PTH1R PTHLH
12 pseudohypoparathyroidism, type ib 9.9 PTH1R PTHLH
13 metaphyseal chondrodysplasia, jansen type 9.9 PTH1R PTHLH
14 chondromyxoid fibroma 9.9 PTH1R PTHLH
15 enchondromatosis, multiple, ollier type 9.9 PTH1R PTHLH
16 endosteal hyperostosis, autosomal dominant 9.9 BMP2 TNFSF11
17 cleft lip 9.8
18 bone resorption disease 9.8 BMP2 TNFSF11
19 skeletal dysplasias 9.8 PTH1R PTHLH
20 pseudohypoparathyroidism 9.8 PTH1R PTHLH
21 bone remodeling disease 9.8 BMP2 TNFSF11
22 peripheral osteosarcoma 9.8 PTHLH SPARC
23 multicentric carpotarsal osteolysis syndrome 9.8 PTHLH TNFSF11
24 osteonecrosis 9.8 BMP2 TNFSF11
25 jaw cancer 9.8 PTHLH TNFSF11
26 keratocystic odontogenic tumor 9.7 PTHLH TNFSF11
27 osteomyelitis 9.7 BMP2 TNFSF11
28 tooth resorption 9.6 BMP2 PTH1R TNFSF11
29 hypoparathyroidism 9.6 PTH1R PTHLH
30 osteochondroma 9.6 BMP2 PTHLH
31 osteochondrodysplasia 9.5 PTH1R PTHLH
32 aortic valve disease 2 9.5 BMP2 SPARC TNFSF11
33 clear cell chondrosarcoma 9.5 PTH1R PTHLH SPARC
34 primary hyperparathyroidism 9.4 PTH1R PTHLH
35 chondroblastoma 9.4 PTH1R PTHLH TNFSF11
36 chondrosarcoma 9.1 PTHLH SPARC
37 bone disease 8.8 PTH1R PTHLH SPARC TNFSF11
38 osteoporosis 8.1 BMP2 PTH1R PTHLH SPARC TNFSF11

Graphical network of the top 20 diseases related to Tooth Ankylosis:



Diseases related to Tooth Ankylosis

Symptoms & Phenotypes for Tooth Ankylosis

UMLS symptoms related to Tooth Ankylosis:


toothache

MGI Mouse Phenotypes related to Tooth Ankylosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.55 BMP2 PTH1R PTHLH SPARC TNFSF11
2 limbs/digits/tail MP:0005371 9.35 BMP2 PTH1R PTHLH SPARC TNFSF11
3 skeleton MP:0005390 9.02 BMP2 PTH1R PTHLH SPARC TNFSF11

Drugs & Therapeutics for Tooth Ankylosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ankylosed Teeth Treatment by Bone Orthodontic Treatment Unknown status NCT02337153

Search NIH Clinical Center for Tooth Ankylosis

Cochrane evidence based reviews: tooth ankylosis

Genetic Tests for Tooth Ankylosis

Anatomical Context for Tooth Ankylosis

MalaCards organs/tissues related to Tooth Ankylosis:

41
Bone

Publications for Tooth Ankylosis

Articles related to Tooth Ankylosis:

# Title Authors Year
1
Diagnosis of tooth ankylosis using panoramic views, cone beam computed tomography, and histological data: a retrospective observational case series study. ( 29016762 )
2017
2
Stability of interceptive/corrective orthodontic treatment for tooth ankylosis and Class II mandibular deficiency: A case report with 10 years follow-up. ( 26275202 )
2015
3
Tooth ankylosis in deciduous teeth of children with cleft lip and/or palate. ( 16089265 )
2004
4
Primary tooth ankylosis: report of case with histological analysis. ( 7560370 )
1995
5
Treatment of multiple tooth ankylosis with removable prosthesis: case report. ( 8015956 )
1994
6
Experimental tooth ankylosis in the monkey. ( 6584053 )
1984
7
Tooth ankylosis. Clinical, radiographic and histological assessments. ( 6438004 )
1984
8
Experimental tooth ankylosis and horizontal tooth movement in the pig. ( 7025810 )
1981
9
Tooth ankylosis in man and the oxytalan fibre meshwork. ( 6940559 )
1980
10
Measurement of space loss resulting from tooth ankylosis. ( 4879576 )
1968

Variations for Tooth Ankylosis

Expression for Tooth Ankylosis

Search GEO for disease gene expression data for Tooth Ankylosis.

Pathways for Tooth Ankylosis

GO Terms for Tooth Ankylosis

Cellular components related to Tooth Ankylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 BMP2 PTHLH PVR SPARC TNFSF11
2 extracellular space GO:0005615 9.02 BMP2 PTHLH PVR SPARC TNFSF11

Biological processes related to Tooth Ankylosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.69 BMP2 PTHLH TNFSF11
2 negative regulation of cell proliferation GO:0008285 9.67 BMP2 PTH1R PTHLH
3 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.48 PTH1R PTHLH
4 bone development GO:0060348 9.46 SPARC TNFSF11
5 cellular response to growth factor stimulus GO:0071363 9.43 BMP2 SPARC
6 inner ear development GO:0048839 9.4 BMP2 SPARC
7 chondrocyte differentiation GO:0002062 9.37 BMP2 PTH1R
8 skeletal system development GO:0001501 9.33 BMP2 PTH1R PTHLH
9 bone resorption GO:0045453 9.32 PTH1R TNFSF11
10 osteoblast development GO:0002076 9.26 PTH1R PTHLH
11 bone mineralization GO:0030282 9.13 BMP2 PTH1R PTHLH
12 ossification GO:0001503 8.92 BMP2 PTH1R SPARC TNFSF11

Sources for Tooth Ankylosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....