MCID: TTH001
MIFTS: 28

Tooth Ankylosis

Categories: Bone diseases, Oral diseases

Aliases & Classifications for Tooth Ankylosis

MalaCards integrated aliases for Tooth Ankylosis:

Name: Tooth Ankylosis 12 43 15 71
Ankylosis of Teeth 12
Ankylosis of Tooth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12661
ICD9CM 34 521.6
MeSH 43 D020254
SNOMED-CT 67 14901003
ICD10 32 K03.5
UMLS 71 C0155930

Summaries for Tooth Ankylosis

MalaCards based summary : Tooth Ankylosis, also known as ankylosis of teeth, is related to ankylosis and permanent molars, secondary retention of, and has symptoms including toothache An important gene associated with Tooth Ankylosis is PTH1R (Parathyroid Hormone 1 Receptor), and among its related pathways/superpathways is Elastic fibre formation. Affiliated tissues include bone, salivary gland and bone marrow, and related phenotypes are growth/size/body region and skeleton

Wikipedia : 74 Tooth ankylosis is the pathological fusion between alveolar bone and the cementum of teeth, which is a... more...

Related Diseases for Tooth Ankylosis

Graphical network of the top 20 diseases related to Tooth Ankylosis:



Diseases related to Tooth Ankylosis

Symptoms & Phenotypes for Tooth Ankylosis

UMLS symptoms related to Tooth Ankylosis:


toothache

MGI Mouse Phenotypes related to Tooth Ankylosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.5 AMBN BMP2 GDF5 MYO1H PTH1R SPRY4
2 skeleton MP:0005390 9.1 AMBN BMP2 GDF5 PTH1R SPRY4 SPTA1

Drugs & Therapeutics for Tooth Ankylosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Validation of Measurements of the Movement of Stiff Treated Teeth and Orthodontic Corticotomy Recruiting NCT02337153

Search NIH Clinical Center for Tooth Ankylosis

Cochrane evidence based reviews: tooth ankylosis

Genetic Tests for Tooth Ankylosis

Anatomical Context for Tooth Ankylosis

MalaCards organs/tissues related to Tooth Ankylosis:

40
Bone, Salivary Gland, Bone Marrow

Publications for Tooth Ankylosis

Articles related to Tooth Ankylosis:

(show all 39)
# Title Authors PMID Year
1
Orthodontic treatment recommendation and expected adverse reactions in patients with a history of dental trauma: A survey among general dentists, paediatric dentists, and orthodontic specialists. 61
31803975 2019
2
Intentional replantation of periodontally involved hopeless teeth: a case series study. 61
31410671 2019
3
Effectiveness of a Piezoelectric-Assisted Distraction Osteogenesis Procedure for the Treatment of Ankylosed Permanent Front Teeth. 61
30817516 2019
4
Effects of platelet-rich plasma on tooth replantation in dogs: a histologic and histomorphometric analysis. 61
30202606 2018
5
Diagnosis of tooth ankylosis using panoramic views, cone beam computed tomography, and histological data: a retrospective observational case series study. 61
29016762 2018
6
Open versus closed surgical exposure for permanent impacted canines: a systematic review and meta-analyses. 61
29106474 2018
7
Dental anomalies: prevalence and associations between them in a large sample of non-orthodontic subjects, a cross-sectional study. 61
28284207 2017
8
Multidisciplinary approach for replacement 
root resorption following severe intrusive luxation: 
A case report of decoronation. 61
28555199 2017
9
Stability of interceptive/corrective orthodontic treatment for tooth ankylosis and Class II mandibular deficiency: A case report with 10 years follow-up. 61
26275202 2015
10
[Periodontal tissue in a bio-implant by periodontal ligament cells sheet and bone marrow stromal cells sheet]. 61
24731419 2014
11
RANK, RANKL and OPG expressions in a permanent molar with a replacement resorption. 61
22249845 2013
12
Bone morphogenic protein-2 induces apoptosis and cytotoxicity in periodontal ligament cells. 61
22839695 2013
13
Algorithm for the differential diagnosis of posterior open bites: two illustrative cases. 61
22722005 2013
14
Surgical removal of a third molar at risk for mandibular pathologic fracture: case report and clinical considerations. 61
23159121 2012
15
Histology of tooth attachment tissues and plicidentine in Varanus (Reptilia: Squamata), and a discussion of the evolution of amniote tooth attachment. 61
21618268 2011
16
Treatment of ankylosed maxillary central incisors by single-tooth dento-osseous osteotomy and alveolar bone distraction. 61
21074463 2011
17
Orthosurgical treatment including anchorage from a palatal implant to correct an infraoccluded maxillary first molar in a young adult. 61
21130340 2010
18
The etiology of eruption disorders - further evidence of a 'genetic paradigm' 61
20830195 2010
19
Administration of the bisphosphonate zoledronic acid during tooth development inhibits tooth eruption and formation and induces dental abnormalities in rats. 61
20411381 2010
20
Orthodontic treatment of an ankylosed maxillary central incisor through osteogenic distraction. 61
19905868 2010
21
Tooth ankylosis in deciduous teeth of children with cleft lip and/or palate. 61
16089265 2004
22
The role of epithelial remodelling in tooth eruption in larval zebrafish. 61
14586692 2004
23
Abnormal pulp calcification in primary molars after fluoride supplementation. 61
12515068 2002
24
[Application of enamel matrix derivative for tooth transplantation and replantation]. 61
10921237 2000
25
[Etiopathogenic hypotheses on dental ankylosis]. 61
9173220 1997
26
Clinical evaluation of orthodontic treatment after surgical repositioning or transplantation of teeth. 61
9058994 1996
27
Impairment of molar tooth eruption caused by x-radiation. 61
11885253 1996
28
Primary tooth ankylosis: report of case with histological analysis. 61
7560370 1995
29
Treatment of multiple tooth ankylosis with removable prosthesis: case report. 61
8015956 1994
30
[Dento-alveolar injuries]. 61
11820012 1992
31
Severe infraclusion ankylosis: report of three cases. 61
2656792 1989
32
Tooth ankylosis. Clinical, radiographic and histological assessments. 61
6438004 1984
33
Experimental tooth ankylosis in the monkey. 61
6584053 1984
34
Dental fluorosis in cattle. 61
6627951 1983
35
Ethnic variability in the prevalence of submerged primary molars. 61
6960043 1982
36
Experimental tooth ankylosis and horizontal tooth movement in the pig. 61
7025810 1981
37
Tooth ankylosis in man and the oxytalan fibre meshwork. 61
6940559 1980
38
Measurement of space loss resulting from tooth ankylosis. 61
4879576 1968
39
[Problem of included tooth, ankylosis or reinclusion]. 61
13083021 1953

Variations for Tooth Ankylosis

Expression for Tooth Ankylosis

Search GEO for disease gene expression data for Tooth Ankylosis.

Pathways for Tooth Ankylosis

Pathways related to Tooth Ankylosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.49 GDF5 BMP2

GO Terms for Tooth Ankylosis

Biological processes related to Tooth Ankylosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cartilage development GO:0051216 9.54 GDF5 BMP2
2 negative regulation of ERK1 and ERK2 cascade GO:0070373 9.52 SPRY4 SPRY1
3 positive regulation of protein binding GO:0032092 9.51 SPTA1 BMP2
4 regulation of MAPK cascade GO:0043408 9.49 GDF5 BMP2
5 SMAD protein signal transduction GO:0060395 9.48 GDF5 BMP2
6 odontogenesis of dentin-containing tooth GO:0042475 9.46 BMP2 AMBN
7 cell development GO:0048468 9.43 GDF5 BMP2
8 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.4 GDF5 BMP2
9 regulation of signal transduction GO:0009966 9.37 SPRY4 SPRY1
10 bone mineralization GO:0030282 9.32 PTH1R BMP2
11 negative regulation of MAP kinase activity GO:0043407 9.26 SPRY4 SPRY1
12 chondrocyte differentiation GO:0002062 9.16 PTH1R BMP2
13 negative regulation of Ras protein signal transduction GO:0046580 8.96 SPRY4 SPRY1
14 negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 8.62 SPRY4 SPRY1

Molecular functions related to Tooth Ankylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 8.96 GDF5 BMP2
2 growth factor activity GO:0008083 8.8 GDF5 BMP2 AMBN

Sources for Tooth Ankylosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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