MCID: TTH001
MIFTS: 32

Tooth Ankylosis

Categories: Bone diseases, Oral diseases

Aliases & Classifications for Tooth Ankylosis

MalaCards integrated aliases for Tooth Ankylosis:

Name: Tooth Ankylosis 12 45 15 74
Ankylosis of Teeth 12
Ankylosis of Tooth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12661
ICD9CM 36 521.6
MeSH 45 D020254
SNOMED-CT 69 14901003
ICD10 34 K03.5
UMLS 74 C0155930

Summaries for Tooth Ankylosis

MalaCards based summary : Tooth Ankylosis, also known as ankylosis of teeth, is related to permanent molars, secondary retention of and ankylosis, and has symptoms including toothache An important gene associated with Tooth Ankylosis is PTH1R (Parathyroid Hormone 1 Receptor), and among its related pathways/superpathways are Senescence and Autophagy in Cancer and Parathyroid hormone synthesis, secretion and action. Related phenotypes are craniofacial and growth/size/body region

Wikipedia : 77 Tooth ankylosis is the pathological fusing of cementum or dentine of a tooth root to the alveolar bone.... more...

Related Diseases for Tooth Ankylosis

Diseases related to Tooth Ankylosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 permanent molars, secondary retention of 11.2
2 ankylosis 10.5
3 teeth hard tissue disease 10.1 AMBN TNFSF11
4 dental pulp necrosis 10.1 AMBN BMP2
5 osseous heteroplasia, progressive 10.0 BMP2 SPARC
6 glucocorticoid-induced osteoporosis 10.0 BMP2 TNFSF11
7 cleft lip 10.0
8 ischemic bone disease 10.0 BMP2 TNFSF11
9 juxtacortical chondroma 10.0 PTH1R PTHLH
10 hypercalcemia, infantile, 1 10.0 PTH1R PTHLH
11 brittle bone disorder 10.0 PTH1R SPARC
12 osteofibrous dysplasia 10.0 BMP2 SPARC
13 metaphyseal chondrodysplasia, jansen type 9.9 PTH1R PTHLH
14 chondromyxoid fibroma 9.9 PTH1R PTHLH
15 enchondromatosis, multiple, ollier type 9.9 PTH1R PTHLH
16 ameloblastoma 9.9 AMBN TNFSF11
17 chondrosarcoma 9.9 PTHLH SPARC
18 pseudohypoparathyroidism, type ib 9.9 PTH1R PTHLH
19 endosteal hyperostosis, autosomal dominant 9.9 BMP2 TNFSF11
20 pseudohypoparathyroidism 9.9 PTH1R PTHLH
21 bone resorption disease 9.9 BMP2 TNFSF11
22 hypoparathyroidism 9.9 PTH1R PTHLH
23 multicentric carpotarsal osteolysis syndrome 9.9 PTHLH TNFSF11
24 bone remodeling disease 9.9 BMP2 TNFSF11
25 peripheral osteosarcoma 9.9 PTHLH SPARC
26 keratocystic odontogenic tumor 9.9 PTHLH TNFSF11
27 osteonecrosis 9.9 BMP2 TNFSF11
28 tooth resorption 9.8 BMP2 PTH1R TNFSF11
29 osteochondroma 9.8 BMP2 PTHLH
30 osteomyelitis 9.7 BMP2 TNFSF11
31 aortic valve disease 2 9.7 BMP2 SPARC TNFSF11
32 clear cell chondrosarcoma 9.7 PTH1R PTHLH SPARC
33 chondroblastoma 9.7 PTH1R PTHLH TNFSF11
34 primary hyperparathyroidism 9.6 PTH1R PTHLH
35 bone disease 9.4 PTH1R PTHLH SPARC TNFSF11
36 osteoporosis 9.0 BMP2 PTH1R PTHLH SPARC TNFSF11

Graphical network of the top 20 diseases related to Tooth Ankylosis:



Diseases related to Tooth Ankylosis

Symptoms & Phenotypes for Tooth Ankylosis

UMLS symptoms related to Tooth Ankylosis:


toothache

MGI Mouse Phenotypes related to Tooth Ankylosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.8 AMBN BMP2 PTH1R PTHLH SPARC TNFSF11
2 growth/size/body region MP:0005378 9.73 AMBN BMP2 PTH1R PTHLH SPARC TNFSF11
3 limbs/digits/tail MP:0005371 9.55 BMP2 PTH1R PTHLH SPARC TNFSF11
4 neoplasm MP:0002006 9.35 AMBN PTH1R PTHLH SPARC TNFSF11
5 skeleton MP:0005390 9.1 AMBN BMP2 PTH1R PTHLH SPARC TNFSF11

Drugs & Therapeutics for Tooth Ankylosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ankylosed Teeth Treatment by Bone Orthodontic Treatment Unknown status NCT02337153

Search NIH Clinical Center for Tooth Ankylosis

Cochrane evidence based reviews: tooth ankylosis

Genetic Tests for Tooth Ankylosis

Anatomical Context for Tooth Ankylosis

Publications for Tooth Ankylosis

Articles related to Tooth Ankylosis:

(show all 13)
# Title Authors Year
1
Diagnosis of tooth ankylosis using panoramic views, cone beam computed tomography, and histological data: a retrospective observational case series study. ( 29016762 )
2018
2
Stability of interceptive/corrective orthodontic treatment for tooth ankylosis and Class II mandibular deficiency: A case report with 10 years follow-up. ( 26275202 )
2015
3
Tooth ankylosis in deciduous teeth of children with cleft lip and/or palate. ( 16089265 )
2004
4
Primary tooth ankylosis: report of case with histological analysis. ( 7560370 )
1995
5
Treatment of multiple tooth ankylosis with removable prosthesis: case report. ( 8015956 )
1994
6
Ankylosis of teeth in the developing dentition. ( 3460109 )
1986
7
Tooth ankylosis. Clinical, radiographic and histological assessments. ( 6438004 )
1984
8
Experimental tooth ankylosis in the monkey. ( 6584053 )
1984
9
Experimental tooth ankylosis and horizontal tooth movement in the pig. ( 7025810 )
1981
10
Tooth ankylosis in man and the oxytalan fibre meshwork. ( 6940559 )
1980
11
Ankylosis of teeth following thermal injury. ( 4272008 )
1971
12
Measurement of space loss resulting from tooth ankylosis. ( 4879576 )
1968
13
Ankylosis of teeth. ( 5217081 )
1965

Variations for Tooth Ankylosis

Expression for Tooth Ankylosis

Search GEO for disease gene expression data for Tooth Ankylosis.

Pathways for Tooth Ankylosis

GO Terms for Tooth Ankylosis

Cellular components related to Tooth Ankylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 AMBN BMP2 PTHLH SPARC TNFSF11

Biological processes related to Tooth Ankylosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.69 BMP2 PTH1R PTHLH
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.52 PTH1R PTHLH
3 cellular response to growth factor stimulus GO:0071363 9.49 BMP2 SPARC
4 odontogenesis of dentin-containing tooth GO:0042475 9.48 AMBN BMP2
5 bone development GO:0060348 9.46 SPARC TNFSF11
6 regulation of signaling receptor activity GO:0010469 9.46 AMBN BMP2 PTHLH TNFSF11
7 inner ear development GO:0048839 9.43 BMP2 SPARC
8 skeletal system development GO:0001501 9.43 BMP2 PTH1R PTHLH
9 chondrocyte differentiation GO:0002062 9.4 BMP2 PTH1R
10 bone resorption GO:0045453 9.37 PTH1R TNFSF11
11 osteoblast development GO:0002076 9.32 PTH1R PTHLH
12 bone mineralization GO:0030282 9.13 BMP2 PTH1R PTHLH
13 ossification GO:0001503 8.92 BMP2 PTH1R SPARC TNFSF11

Sources for Tooth Ankylosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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