MCID: TTH001
MIFTS: 31

Tooth Ankylosis

Categories: Bone diseases, Oral diseases

Aliases & Classifications for Tooth Ankylosis

MalaCards integrated aliases for Tooth Ankylosis:

Name: Tooth Ankylosis 12 44 15 72
Ankylosis of Teeth 12
Ankylosis of Tooth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12661
ICD9CM 35 521.6
MeSH 44 D020254
SNOMED-CT 68 14901003
ICD10 33 K03.5
UMLS 72 C0155930

Summaries for Tooth Ankylosis

MalaCards based summary : Tooth Ankylosis, also known as ankylosis of teeth, is related to permanent molars, secondary retention of and ankylosis, and has symptoms including toothache An important gene associated with Tooth Ankylosis is PTH1R (Parathyroid Hormone 1 Receptor), and among its related pathways/superpathways are Parathyroid hormone synthesis, secretion and action and Endochondral Ossification. Affiliated tissues include bone, salivary gland and bone marrow, and related phenotypes are craniofacial and limbs/digits/tail

Wikipedia : 75 Tooth ankylosis is the pathological fusing of cementum or dentine of a tooth root to the alveolar bone.... more...

Related Diseases for Tooth Ankylosis

Diseases related to Tooth Ankylosis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 38, show less)
# Related Disease Score Top Affiliating Genes
1 permanent molars, secondary retention of 11.4
2 ankylosis 10.5
3 prolapse of female genital organ 10.2 SPARC PVR
4 dental pulp necrosis 10.2 BMP2 AMBN
5 teeth hard tissue disease 10.2 TNFSF11 AMBN
6 osseous heteroplasia, progressive 10.1 SPARC BMP2
7 brittle bone disorder 10.0 SPARC PTH1R
8 hair whorl 10.0
9 root resorption 10.0
10 cleft lip 10.0
11 osteofibrous dysplasia 10.0 SPARC BMP2
12 juxtacortical chondroma 10.0 PTHLH PTH1R
13 hypercalcemia, infantile, 1 10.0 PTHLH PTH1R
14 glucocorticoid-induced osteoporosis 10.0 TNFSF11 BMP2
15 ischemic bone disease 10.0 TNFSF11 BMP2
16 chondromyxoid fibroma 9.9 PTHLH PTH1R
17 metaphyseal chondrodysplasia, jansen type 9.9 PTHLH PTH1R
18 ameloblastoma 9.9 TNFSF11 AMBN
19 enchondromatosis, multiple, ollier type 9.9 PTHLH PTH1R
20 pseudohypoparathyroidism, type ib 9.9 PTHLH PTH1R
21 pseudohypoparathyroidism 9.9 PTHLH PTH1R
22 peripheral osteosarcoma 9.9 SPARC PTHLH
23 endosteal hyperostosis, autosomal dominant 9.8 TNFSF11 BMP2
24 hypoparathyroidism 9.8 PTHLH PTH1R
25 bone resorption disease 9.8 TNFSF11 BMP2
26 multicentric carpotarsal osteolysis syndrome 9.8 TNFSF11 PTHLH
27 bone remodeling disease 9.8 TNFSF11 BMP2
28 keratocystic odontogenic tumor 9.8 TNFSF11 PTHLH
29 osteonecrosis 9.8 TNFSF11 BMP2
30 tooth resorption 9.7 TNFSF11 PTH1R BMP2
31 osteochondroma 9.7 PTHLH BMP2
32 aortic valve disease 2 9.6 TNFSF11 SPARC BMP2
33 clear cell chondrosarcoma 9.6 SPARC PTHLH PTH1R
34 osteomyelitis 9.6 TNFSF11 BMP2
35 chondroblastoma 9.5 TNFSF11 PTHLH PTH1R
36 primary hyperparathyroidism 9.4 PTHLH PTH1R
37 bone disease 9.1 TNFSF11 SPARC PTHLH PTH1R
38 osteoporosis 8.5 TNFSF11 SPARC PTHLH PTH1R BMP2

Graphical network of the top 20 diseases related to Tooth Ankylosis:



Diseases related to Tooth Ankylosis

Symptoms & Phenotypes for Tooth Ankylosis

UMLS symptoms related to Tooth Ankylosis:


toothache

MGI Mouse Phenotypes related to Tooth Ankylosis:

46 (showing 4, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.73 AMBN BMP2 PTH1R PTHLH SPARC TNFSF11
2 limbs/digits/tail MP:0005371 9.55 BMP2 PTH1R PTHLH SPARC TNFSF11
3 neoplasm MP:0002006 9.35 AMBN PTH1R PTHLH SPARC TNFSF11
4 skeleton MP:0005390 9.1 AMBN BMP2 PTH1R PTHLH SPARC TNFSF11

Drugs & Therapeutics for Tooth Ankylosis

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 Study of Validation of Measurements of the Movement of Stiff Treated Teeth and Orthodontic Corticotomy Recruiting NCT02337153

Search NIH Clinical Center for Tooth Ankylosis

Cochrane evidence based reviews: tooth ankylosis

Genetic Tests for Tooth Ankylosis

Anatomical Context for Tooth Ankylosis

MalaCards organs/tissues related to Tooth Ankylosis:

41
Bone, Salivary Gland, Bone Marrow

Publications for Tooth Ankylosis

Articles related to Tooth Ankylosis:

(showing 38, show less)
# Title Authors PMID Year
1
Intentional replantation of periodontally involved hopeless teeth: a case series study. 38
31410671 2019
2
Effectiveness of a Piezoelectric-Assisted Distraction Osteogenesis Procedure for the Treatment of Ankylosed Permanent Front Teeth. 38
30817516 2019
3
Effects of platelet-rich plasma on tooth replantation in dogs: a histologic and histomorphometric analysis. 38
30202606 2018
4
Diagnosis of tooth ankylosis using panoramic views, cone beam computed tomography, and histological data: a retrospective observational case series study. 38
29016762 2018
5
Open versus closed surgical exposure for permanent impacted canines: a systematic review and meta-analyses. 38
29106474 2018
6
Dental anomalies: prevalence and associations between them in a large sample of non-orthodontic subjects, a cross-sectional study. 38
28284207 2017
7
Multidisciplinary approach for replacement 
root resorption following severe intrusive luxation: 
A case report of decoronation. 38
28555199 2017
8
Stability of interceptive/corrective orthodontic treatment for tooth ankylosis and Class II mandibular deficiency: A case report with 10 years follow-up. 38
26275202 2015
9
[Periodontal tissue in a bio-implant by periodontal ligament cells sheet and bone marrow stromal cells sheet]. 38
24731419 2014
10
RANK, RANKL and OPG expressions in a permanent molar with a replacement resorption. 38
22249845 2013
11
Bone morphogenic protein-2 induces apoptosis and cytotoxicity in periodontal ligament cells. 38
22839695 2013
12
Algorithm for the differential diagnosis of posterior open bites: two illustrative cases. 38
22722005 2013
13
Surgical removal of a third molar at risk for mandibular pathologic fracture: case report and clinical considerations. 38
23159121 2012
14
Histology of tooth attachment tissues and plicidentine in Varanus (Reptilia: Squamata), and a discussion of the evolution of amniote tooth attachment. 38
21618268 2011
15
Treatment of ankylosed maxillary central incisors by single-tooth dento-osseous osteotomy and alveolar bone distraction. 38
21074463 2011
16
Orthosurgical treatment including anchorage from a palatal implant to correct an infraoccluded maxillary first molar in a young adult. 38
21130340 2010
17
The etiology of eruption disorders - further evidence of a 'genetic paradigm' 38
20830195 2010
18
Administration of the bisphosphonate zoledronic acid during tooth development inhibits tooth eruption and formation and induces dental abnormalities in rats. 38
20411381 2010
19
Orthodontic treatment of an ankylosed maxillary central incisor through osteogenic distraction. 38
19905868 2010
20
Tooth ankylosis in deciduous teeth of children with cleft lip and/or palate. 38
16089265 2004
21
The role of epithelial remodelling in tooth eruption in larval zebrafish. 38
14586692 2004
22
Abnormal pulp calcification in primary molars after fluoride supplementation. 38
12515068 2002
23
[Application of enamel matrix derivative for tooth transplantation and replantation]. 38
10921237 2000
24
[Etiopathogenic hypotheses on dental ankylosis]. 38
9173220 1997
25
Clinical evaluation of orthodontic treatment after surgical repositioning or transplantation of teeth. 38
9058994 1996
26
Impairment of molar tooth eruption caused by x-radiation. 38
11885253 1996
27
Primary tooth ankylosis: report of case with histological analysis. 38
7560370 1995
28
Treatment of multiple tooth ankylosis with removable prosthesis: case report. 38
8015956 1994
29
[Dento-alveolar injuries]. 38
11820012 1992
30
Severe infraclusion ankylosis: report of three cases. 38
2656792 1989
31
Tooth ankylosis. Clinical, radiographic and histological assessments. 38
6438004 1984
32
Experimental tooth ankylosis in the monkey. 38
6584053 1984
33
Dental fluorosis in cattle. 38
6627951 1983
34
Ethnic variability in the prevalence of submerged primary molars. 38
6960043 1982
35
Experimental tooth ankylosis and horizontal tooth movement in the pig. 38
7025810 1981
36
Tooth ankylosis in man and the oxytalan fibre meshwork. 38
6940559 1980
37
Measurement of space loss resulting from tooth ankylosis. 38
4879576 1968
38
[Problem of included tooth, ankylosis or reinclusion]. 38
13083021 1953

Variations for Tooth Ankylosis

Expression for Tooth Ankylosis

Search GEO for disease gene expression data for Tooth Ankylosis.

Pathways for Tooth Ankylosis

GO Terms for Tooth Ankylosis

Cellular components related to Tooth Ankylosis according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 TNFSF11 SPARC PVR PTHLH BMP2
2 extracellular region GO:0005576 9.1 TNFSF11 SPARC PVR PTHLH BMP2 AMBN

Biological processes related to Tooth Ankylosis according to GeneCards Suite gene sharing:

(showing 11, show less)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.67 PTHLH PTH1R BMP2
2 cellular response to growth factor stimulus GO:0071363 9.48 SPARC BMP2
3 odontogenesis of dentin-containing tooth GO:0042475 9.46 BMP2 AMBN
4 bone development GO:0060348 9.43 TNFSF11 SPARC
5 inner ear development GO:0048839 9.4 SPARC BMP2
6 chondrocyte differentiation GO:0002062 9.37 PTH1R BMP2
7 skeletal system development GO:0001501 9.33 PTHLH PTH1R BMP2
8 bone resorption GO:0045453 9.32 TNFSF11 PTH1R
9 osteoblast development GO:0002076 9.26 PTHLH PTH1R
10 bone mineralization GO:0030282 9.13 PTHLH PTH1R BMP2
11 ossification GO:0001503 8.92 TNFSF11 SPARC PTH1R BMP2

Sources for Tooth Ankylosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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