Aliases & Classifications for Tooth Disease

MalaCards integrated aliases for Tooth Disease:

Name: Tooth Disease 12 15 17
Tooth Diseases 45 74
Tooth Disorders 44

Classifications:



External Ids:

Disease Ontology 12 DOID:1091
MeSH 45 D014076
SNOMED-CT 69 72722003
UMLS 74 C0040435

Summaries for Tooth Disease

MedlinePlus : 44 What are teeth? Your teeth are made of a hard, bonelike material. There are four parts: Enamel, your tooth's hard surface Dentin, the hard yellow part under the enamel Cementum, the hard tissue that covers the root and keeps your teeth in place Pulp, the soft connective tissue in the center of your tooth. It contains nerves and blood vessels. You need your teeth for many activities that you may take for granted. These include eating, speaking and even smiling. What are tooth disorders? There are many different problems that can affect your teeth, including Tooth decay - damage to a tooth's surface, which can lead to cavities Abscess - a pocket of pus, caused by a tooth infection Impacted tooth - a tooth did not erupt (break through the gum) when it should have. It is usually wisdom teeth that are impacted, but it can sometimes happen to other teeth. Misaligned teeth (malocclusion) Tooth injuries such as broken or chipped teeth What causes tooth disorders? The causes of tooth disorders varies, depending on the problem. Sometimes the cause is not taking good care of your teeth. In other cases, you may have been born with the problem or the cause is an accident. What are the symptoms of tooth disorders? The symptoms can vary, depending on the problem. Some of the more common symptoms include Abnormal color or shape of the tooth Tooth pain Worn-down teeth How are tooth disorders diagnosed? Your dentist will ask about your symptoms, look at your teeth, and probe them with dental instruments. In some cases, you may need dental x-rays. What are the treatments for tooth disorders? The treatment will depend on the problem. Some common treatments are Fillings for cavities Root canals for cavities or infections that affect the pulp (inside of the tooth) Extractions (pulling teeth) for teeth that are impacted and causing problems or are too damaged to be fixed. You may also have a tooth or teeth pulled because of overcrowding in your mouth. Can tooth disorders be prevented? The main thing that you can do to prevent tooth disorders is to take good care of your teeth: Brush your teeth twice a day with a fluoride toothpaste Clean between your teeth every day with floss or another type of between-the-teeth cleaner Limit sugary snacks and drinks Don't smoke or chew tobacco See your dentist or oral health professional regularly

MalaCards based summary : Tooth Disease, also known as tooth diseases, is related to charcot-marie-tooth disease, axonal, type 2a1 and charcot-marie-tooth disease, axonal, type 2j, and has symptoms including snoring, halitosis and toothache. An important gene associated with Tooth Disease is SH3TC2 (SH3 Domain And Tetratricopeptide Repeats 2), and among its related pathways/superpathways is Neural Crest Differentiation. The drugs Acetylcholine and Calcium Carbonate have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and brain, and related phenotypes are no effect and Increased gamma-H2AX phosphorylation

Related Diseases for Tooth Disease

Diseases related to Tooth Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 306)
# Related Disease Score Top Affiliating Genes
1 charcot-marie-tooth disease, axonal, type 2a1 34.5 KIF1B MFN2
2 charcot-marie-tooth disease, axonal, type 2j 34.5 KIF1B MPZ
3 charcot-marie-tooth disease, axonal, type 2i 34.5 KIF1B MPZ
4 charcot-marie-tooth disease, x-linked dominant, 1 34.4 GJB1 MPZ PMP22
5 charcot-marie-tooth disease, type 4b1 34.4 GDAP1 MTMR2 SBF2
6 charcot-marie-tooth disease, type 4a 34.4 GDAP1 MTMR2 SBF2
7 charcot-marie-tooth disease, type 4b2 34.4 GDAP1 MTMR2 SBF2
8 charcot-marie-tooth disease, axonal, type 2q 34.4 EGR2 MPZ
9 charcot-marie-tooth disease, axonal, type 2d 34.4 GJB1 KIF1B MPZ PMP22
10 charcot-marie-tooth disease, demyelinating, type 4f 34.4 GDAP1 MTMR2 SBF2
11 charcot-marie-tooth disease, demyelinating, type 1f 34.4 GJB1 MPZ NEFL PMP22
12 charcot-marie-tooth disease, type 4b3 34.3 GDAP1 MTMR2 SBF2
13 charcot-marie-tooth disease, type 4j 34.3 FIG4 MTMR2 SBF2
14 charcot-marie-tooth disease, axonal, type 2b 34.2 EGR2 GJB1 KIF1B MPZ PMP22
15 charcot-marie-tooth disease, type 4d 34.2 GDAP1 GJB1 MFN2 NDRG1 SH3TC2
16 charcot-marie-tooth disease, axonal, type 2f 34.2 GJB1 HSPB1 KIF1B MPZ
17 charcot-marie-tooth disease, axonal, type 2k 34.2 GDAP1 HSPB8 KIF1B MFN2
18 charcot-marie-tooth disease, demyelinating, type 1b 34.1 EGR2 GJB1 KIF1B MPZ MTMR2 PMP22
19 charcot-marie-tooth disease type 2a 34.1 KIF1B MFN2
20 charcot-marie-tooth disease, axonal, type 2l 34.0 HSPB1 HSPB8 KIF1B MPZ
21 charcot-marie-tooth disease, x-linked recessive, 3 33.9 GJB1 HSPB8
22 charcot-marie-tooth disease, demyelinating, type 1c 33.9 EGR2 GJB1 KIF1B LITAF MPZ NEFL
23 charcot-marie-tooth disease, demyelinating, type 1a 33.9 EGR2 GDAP1 GJB1 KIF1B MFN2 MPZ
24 charcot-marie-tooth disease, demyelinating, type 1d 33.8 EGR2 GJB1 KIF1B MPZ MTMR2 NDRG1
25 neuropathy, hereditary motor and sensory, russe type 33.7 EGR2 NDRG1 SH3TC2
26 charcot-marie-tooth disease and deafness 33.6 EGR2 GDAP1 GJB1 KIF1B LITAF MFN2
27 charcot-marie-tooth disease, axonal, type 2e 33.5 EGR2 GDAP1 GJB1 KIF1B LMNA LRSAM1
28 hereditary motor and sensory neuropathy, type iic 33.4 GDAP1 GJB1 KIF1B MFN2 MPZ NDRG1
29 roussy-levy hereditary areflexic dystasia 33.3 MPZ PMP22
30 hypertrophic neuropathy of dejerine-sottas 32.8 EGR2 FGD4 GDAP1 GJB1 KIF1B LITAF
31 charcot-marie-tooth hereditary neuropathy 32.6 MPZ PMP22
32 foot drop 32.4 MPZ PMP22
33 congenital hypomyelination neuropathy 32.1 MPZ PMP22
34 charcot-marie-tooth disease 31.6 EGR2 FGD4 FIG4 GDAP1 GJB1 HSPB1
35 neuropathy, hereditary, with liability to pressure palsies 31.6 EGR2 GDAP1 GJB1 KIF1B LITAF MFN2
36 neuropathy 31.0 EGR2 GDAP1 GJB1 MFN2 MPZ PMP22
37 polyneuropathy 30.8 GDAP1 MPZ PMP22
38 axonal neuropathy 30.2 GDAP1 LMNA MFN2 PMP22
39 sensory peripheral neuropathy 30.0 EGR2 FGD4 GDAP1 GJB1 LITAF MFN2
40 cauda equina syndrome 30.0 EGR2 PMP22
41 early-onset glaucoma 30.0 MTMR2 SBF2
42 amyotrophic lateral sclerosis 1 29.6 FIG4 HSPB1 HSPB8 NEFL
43 peripheral nervous system disease 29.6 EGR2 GDAP1 GJB1 KIF1B LITAF MFN2
44 charcot-marie-tooth disease, type 4h 12.6
45 charcot-marie-tooth disease, dominant intermediate b 12.6
46 charcot-marie-tooth disease, axonal, type 2p 12.6
47 charcot-marie-tooth disease, type 4c 12.6
48 charcot-marie-tooth disease, type 4k 12.5
49 charcot-marie-tooth disease, axonal, type 2t 12.5
50 charcot-marie-tooth disease, dominant intermediate e 12.5

Graphical network of the top 20 diseases related to Tooth Disease:



Diseases related to Tooth Disease

Symptoms & Phenotypes for Tooth Disease

UMLS symptoms related to Tooth Disease:


snoring, halitosis, toothache, poor dentition

GenomeRNAi Phenotypes related to Tooth Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 EGR2 FGD4 FIG4 GDAP1 GJB1 HSPB1
2 Increased gamma-H2AX phosphorylation GR00053-A 9.56 EGR2 GJB1 HSPB1 LMNA MPZ NDRG1

MGI Mouse Phenotypes related to Tooth Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.33 EGR2 FGD4 FIG4 GDAP1 GJB1 KIF1B
2 homeostasis/metabolism MP:0005376 10.13 EGR2 GDAP1 GJB1 HSPB1 HSPB8 KIF1B
3 cellular MP:0005384 10.07 EGR2 GDAP1 GJB1 HSPB1 HSPB8 LITAF
4 mortality/aging MP:0010768 9.97 EGR2 FIG4 GJB1 HSPB8 KIF1B LMNA
5 limbs/digits/tail MP:0005371 9.86 EGR2 FIG4 GDAP1 KIF1B LMNA MED25
6 muscle MP:0005369 9.56 FIG4 HSPB8 KIF1B LMNA MFN2 NDRG1
7 nervous system MP:0003631 9.55 EGR2 FGD4 FIG4 GDAP1 GJB1 KIF1B

Drugs & Therapeutics for Tooth Disease

Drugs for Tooth Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 457)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4,Phase 2,Phase 1 51-84-3 187
2
Calcium Carbonate Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 471-34-1
3
Hydrogen peroxide Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1 7722-84-1 784
4
carbamide peroxide Approved Phase 4,Phase 3,Not Applicable 124-43-6
5
Glycerol Approved, Investigational Phase 4 56-81-5 753
6 sodium fluoride Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 7681-49-4
7
Tea tree oil Approved Phase 4,Not Applicable
8
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55-56-1 2713 9552079
9
Methamphetamine Approved, Illicit Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 537-46-2 10836
10
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 62-31-7, 51-61-6 681
11
Ethanol Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 64-17-5 702
12
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
13
Tetracaine Approved, Vet_approved Phase 4 94-24-6 5411
14
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
15
Ephedrine Approved Phase 4 299-42-3 9294
16
Phenylephrine Approved Phase 4 59-42-7 6041
17
tannic acid Approved Phase 4,Phase 3,Not Applicable 1401-55-4
18
Pseudoephedrine Approved Phase 4 90-82-4 7028
19
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 137-58-6 3676
20
Benzocaine Approved, Investigational Phase 4,Phase 3,Not Applicable 1994-09-7, 94-09-7 2337
21
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Early Phase 1,Not Applicable 50-23-7 5754
22
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 2,Early Phase 1,Not Applicable 50-03-3
23
Diclofenac Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 15307-86-5 3033
24
Piroxicam Approved, Investigational Phase 4,Phase 3,Not Applicable,Early Phase 1 36322-90-4 54676228 5280452
25
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Not Applicable,Early Phase 1 50-02-2 5743
26
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Not Applicable,Early Phase 1 1177-87-3
27
Clindamycin Approved, Vet_approved Phase 4,Not Applicable 18323-44-9 29029
28
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 26787-78-0 33613
29
Zinc oxide Approved Phase 4,Phase 2,Not Applicable 1314-13-2
30
Salicylic acid Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 69-72-7 338
31
Eugenol Approved Phase 4,Phase 2,Not Applicable 97-53-0 3314
32
Zinc Approved, Investigational Phase 4,Phase 2,Not Applicable 7440-66-6 32051
33
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 15687-27-1 3672
34
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable,Early Phase 1 22916-47-8 4189
35
Sorbitol Approved Phase 4,Phase 2,Phase 3,Not Applicable 50-70-4 5780
36
Iodine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7553-56-2 807
37
Povidone Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9003-39-8
38
Povidone-iodine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 25655-41-8
39
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
40
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 93-14-1 3516
41
Codeine Approved, Illicit Phase 4,Phase 3,Phase 2 76-57-3 5284371
42
Esomeprazole Approved, Investigational Phase 4,Phase 1,Phase 2 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
43
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 22204-53-1 156391 1302
44
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 51-43-4 5816
45
Racepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 329-65-7 838
46
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3 302-25-0
47
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
48
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3 2921-57-5
49
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
50
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3 59467-70-8 4192

Interventional clinical trials:

(show top 50) (show all 1634)
# Name Status NCT ID Phase Drugs
1 TM vs TSV Implants Loaded Early vs Conventional in Anterior and Posterior Areas Unknown status NCT02158377 Phase 4
2 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
3 Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT Unknown status NCT02702505 Phase 4
4 Study of the Safety and Efficacy of Botox in Bruxism Unknown status NCT00908050 Phase 4 Botulinum toxin type A
5 Combined Bleaching Technique: Efficacy and Tooth Sensitivity Unknown status NCT03089216 Phase 4 8% arginine and calcium carbonate
6 Effectiveness of Nanohydroxyapetite Paste on Reducing Dentin Hypersensitivity Unknown status NCT02936830 Phase 4 5% Sodium Fluoride Varnish;15% Nanohydroxyapetite paste;Glycerol
7 Effect of Different Mouthrinses in Plaque Formation Unknown status NCT02695901 Phase 4 Chlorhexidine gluconate 0.12% (PerioGard®);Nanoparticle solution of M. alternifolia oil (0.3%).
8 Consumption Effect of Probiotic Products on Salivary Cariogenic Bacterial Counts in Preschool Children. Unknown status NCT02692625 Phase 4
9 Efficacy of Calcium Silicate Pulp-capping; a Randomized Controlled Clinical Trial Unknown status NCT02201641 Phase 4
10 Dental Caries Management by Risk Assessment: Identification and Treatment of Risk Factors Among (IDF) Personnel Unknown status NCT01142440 Phase 4
11 Manually Versus Digitally Fabricated Removable Partial Dentures Unknown status NCT01191073 Phase 4
12 Elmex Gel Efficacy in Preventing White Spot Lesions Unknown status NCT00268138 Phase 4 elmex gel
13 Clinical Comparison of RPDs Retained by Conical and Galvanoformed Double Crowns. Unknown status NCT00176215 Phase 4
14 Evaluation of a Lateral Window Technique Augmentation for Maxillary Sinus Using Ultrasound Activated Pins Unknown status NCT02449707 Phase 4
15 Essential Oils With and Without Alcohol: Substantivity and Antiplaque Effect Unknown status NCT03146390 Phase 4 Essential oils;Alcohol free essential oils
16 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
17 Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2). Unknown status NCT01778699 Phase 4
18 Efficacy of Different Chlorhexidine Concentrations Unknown status NCT02911766 Phase 4 Chlorhexidine 0.2% Mouthrinse;Chlorhexidine 0.12% mouthrinse;Chlorhexidine 0.06% mouthrinse
19 Comparative Efficacy of 20% Benzocaine Versus TAC Alternate Gel Unknown status NCT00846690 Phase 4 benzocaine;TAC alternate gel
20 Ketamine on Acute Pain in Females and Males Completed NCT00232492 Phase 4 Placebo males;Ketamine 0,1 mg/kg males;Ketamine 0,3 mg/kg males;Ketamine 0,5 mg/kg males;Placebo females;Ketamine 0,1 mg/kg females;Ketamine 0,3 mg/kg females;Ketamine 0,5 mg/kg females
21 Combined Dental Bleaching Protocols and Time Required to Achieve Satisfactory Color Completed NCT03514797 Phase 4 Bleaching Agents;Bleaching Agents
22 Topical Hydrocortisone for Pain and Edema Control After Third Molar Surgery Completed NCT03179813 Phase 4
23 The Effect of Whitening Toothpaste on Tooth Color Associated With Bleaching Process Completed NCT03163069 Phase 4
24 Efficacy of a Whitening Dentifrice on Tooth Discoloration Completed NCT02741427 Phase 4
25 Effectiveness of Diclofenac and Its Association to Codeine After Lower Third Molar Extraction. Completed NCT02547896 Phase 4 Codeine + Diclofenac;Diclofenac
26 Comparison of the Clinical Efficacy of Naproxen, Associated or Not With Esomeprazol, in Lower Third Molar Removal Completed NCT02494856 Phase 4 Surgery with Naproxen;Surgery with Naproxen and Esomeprazole
27 Lower Third Molar Removal With 2% and 4% Articaine Completed NCT02457325 Phase 4 Surgery with 2% articaine;Surgery with 4% articaine
28 Influence of Genotype of CYP2C9 on Clinical Efficacy and Pharmacokinetics of Piroxicam After Lower Third Molar Surgery Completed NCT02450487 Phase 4 Piroxicam
29 Dexamethasone in Lower Third Molar Surgery Completed NCT02416869 Phase 4 4mg Dexamethasone submucosal;8mg Dexamethasone submucosal
30 AUGMENTIN™ in Dental Infections Completed NCT02141217 Phase 4 Amoxicillin/clavulanate;Clindamycin
31 Longevity and Effectiveness of Bleaching in Healthy and Smokers Patients Completed NCT02017873 Phase 4 Peroxide Carbamide 10% - Dental bleaching treatment
32 An Efficacy Study of Stain Control of a 67% Sodium Bicarbonate Containing Toothpaste on Chlorhexidine Tooth Staining Completed NCT01962493 Phase 4 Chlorhexidine digluconate
33 Effect of AcceleDent® Aura on Orthodontic Tooth Movement With Aligners Completed NCT01962012 Phase 4
34 Clinical Effectiveness of In-office Bleaching Activated With a LED/Laser Device Completed NCT01231243 Phase 4
35 BiodentineTM Versus Formocresol Pulpotomy Technique in Primary Molars Completed NCT03779698 Phase 4 Formocresol
36 Indirect Pulp Treatment in Primary Molars Completed NCT03770871 Phase 4 Dycal (Indirect pulp treatment);Vitrebond (Indirect pulp treatment)
37 Effectiveness of a Chlorine Dioxide Spray on Dental Plaque and Respiratory Pathogens in Institutionalized Elders Completed NCT03533335 Phase 4
38 Effect of the Amount of Fluoride Toothpaste on Fluoride Availability in the Oral Fluids in Children Completed NCT03455621 Phase 4
39 MI Varnish for the Prevention of White Spot Lesions Completed NCT03446690 Phase 4 MI Varnish
40 Casein Phosphopeptide--amorphous Calcium Phosphate on Human Enamel Subjected to in Vivo Acid Attacks Completed NCT03426150 Phase 4 CPP-ACP;Placebos
41 Treatment of Immature Permanent Teeth With Three Different Pulp Capping Materials With Partial Pulpotomy Completed NCT03426046 Phase 4 Pulp Capping Agents
42 The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions Completed NCT02953886 Phase 4
43 To Investigate the Efficacy of an Occluding Dentifrice in Dentinal Hypersensitivity (DH) Completed NCT02923895 Phase 4
44 Nano-hydroxyapatite With Potassium Nitrate in the Therapy of the Dental Sensitivity Completed NCT02895321 Phase 4
45 Oral Glucocorticoids Effect on Post Endodontic Pain Completed NCT02819648 Phase 4 Prednisolone
46 Fuji Type VII Sealant Versus Resin Based Sealant. A Clinical Trial Completed NCT02795728 Phase 4
47 Study to Investigate the Efficacy of an Occluding Dentifrice in Providing Relief From Dentine Hypersensitivity Completed NCT02773758 Phase 4
48 Short Term Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity Completed NCT02731833 Phase 4
49 Prevention of Dental Caries Lesions With Fluoride Varnish in Erupting First Permanent Molars Completed NCT02592278 Phase 4 Fluoride Varnish;Control Group
50 Comparison of the Effect of Fluoride Remineralizer Gel and Foam Completed NCT02490592 Phase 4

Search NIH Clinical Center for Tooth Disease

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: tooth diseases

Genetic Tests for Tooth Disease

Anatomical Context for Tooth Disease

MalaCards organs/tissues related to Tooth Disease:

42
Testes, Bone, Brain, Spinal Cord, Kidney, Colon, Ovary

Publications for Tooth Disease

Articles related to Tooth Disease:

(show top 50) (show all 1553)
# Title Authors Year
1
Foot measures in patients with pes cavus with and without charcot-marie-tooth disease: A pilot study. ( 30039580 )
2019
2
Falls in paediatric Charcot-Marie-Tooth disease: a 6-month prospective cohort study. ( 30104392 )
2019
3
X-linked Charcot-Marie-Tooth disease type 5 with recurrent weakness after febrile illness. ( 30177296 )
2019
4
X linked Charcot-Marie-Tooth disease and multiple sclerosis: emerging evidence for an association. ( 30196252 )
2019
5
Genetic profile and onset features of 1005 patients with Charcot-Marie-Tooth disease in Japan. ( 30257968 )
2019
6
Novel GARS mutation presenting as autosomal dominant intermediate Charcot-Marie-Tooth disease. ( 30394614 )
2019
7
Diffusion tensor imaging of the sciatic nerve in Charcot-Marie-Tooth disease type I patients: a prospective case-control study. ( 30635758 )
2019
8
Neurodegenerative Charcot-Marie-Tooth disease as a case study to decipher novel functions of aminoacyl-tRNA synthetases. ( 30643024 )
2019
9
Erratum to: Development and validation of the Charcot-Marie-Tooth Disease Infant Scale. ( 30649217 )
2019
10
MFN2 mutations in Charcot-Marie-Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics. ( 30649465 )
2019
11
Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth disease 1A (CMT1A). ( 30650121 )
2019
12
Mutational screening of the SH3TC2 gene in Greek patients with suspected demyelinating recessive Charcot-Marie-Tooth disease reveals a varied and unusual phenotypic spectrum. ( 30653784 )
2019
13
Dropped head syndrome as a manifestation of Charcot-Marie-Tooth disease type 4C. ( 30658898 )
2019
14
Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons. ( 30663652 )
2019
15
A cryptic splicing mutation in the INF2 gene causing Charcot-Marie-Tooth disease with minimal glomerular dysfunction. ( 30680856 )
2019
16
Replication studies of MIR149 association in Charcot-Marie-Tooth disease type 1A in a European population - response. ( 30683432 )
2019
17
Replication studies of MIR149 association in Charcot-Marie-Tooth disease type 1A in a European population. ( 30683433 )
2019
18
Variation in SIPA1L2 is correlated with phenotype modification in Charcot- Marie- Tooth disease type 1A. ( 30706531 )
2019
19
Generation of a human Charcot-Marie-Tooth disease type 1B (CMT1B) iPSC line, ZJUCHi001-A, with a mutation of c.292C>T in MPZ. ( 30785048 )
2019
20
Generation of induced pluripotent stem cell line, ZJUCHi002-A, from Charcot-Marie-Tooth disease type 2A (CMT2A) patient with a mutation of c.752C>T in MFN2. ( 30807887 )
2019
21
POLG mutations presenting as CMT. ( 30843307 )
2019
22
A novel family with axonal Charcot-Marie-Tooth disease caused by a mutation in the EGR2 gene. ( 30843326 )
2019
23
Novel GARS mutation presenting as autosomal dominant intermediate Charcot-Marie-Tooth disease: Intermediate or axonal? ( 30873681 )
2019
24
Muscle fat quantification using magnetic resonance imaging: case-control study of Charcot-Marie-Tooth disease patients and volunteers. ( 30873759 )
2019
25
Charcot-Marie-Tooth disease with pyramidal features due to a new mutation of EGR2 gene. ( 30889162 )
2019
26
Are novel outcome measures for Charcot-Marie-Tooth disease sensitive to change? The 6-minute walk test and StepWatch™ Activity Monitor in a 12-month longitudinal study. ( 30926199 )
2019
27
Modifier Gene Candidates in Charcot-Marie-Tooth Disease Type 1A: A Case-Only Genome-Wide Association Study. ( 30958311 )
2019
28
Charcot-Marie-Tooth disease type 2CC due to a frameshift mutation of the neurofilament heavy polypeptide gene in an Austrian family. ( 30992180 )
2019
29
A Sporadic Case of Charcot-Marie-Tooth Disease Type 2 with Left Vocal Fold Palsy due to Mitofusin 2 Mutation. ( 30996168 )
2019
30
Balance Impairment in Pediatric Charcot-Marie-Tooth Disease. ( 31026080 )
2019
31
Treatment-induced remission of medulloblastoma using a chemotherapeutic regimen devoid of vincristine in a child with Charcot-Marie-Tooth disease. ( 31043836 )
2019
32
Physical function and performance measures of children and adolescents with Charcot-Marie-Tooth disease. ( 31046526 )
2019
33
A Novel Variant in Non-coding Region of GJB1 Is Associated With X-Linked Charcot-Marie-Tooth Disease Type 1 and Transient CNS Symptoms. ( 31068899 )
2019
34
A multicentre retrospective study of Charcot-Marie-Tooth disease type 4B (CMT4B) due to mutations in Myotubularin-related proteins (MTMRs). ( 31070812 )
2019
35
Body composition and its association with physical performance, quality of life, and clinical indictors in Charcot-Marie-Tooth disease: a pilot study. ( 29096547 )
2019
36
Genetic analysis of Charcot-Marie-Tooth disease in Denmark and the implementation of a next generation sequencing platform. ( 29653220 )
2019
37
[Analysis of GDAP1 gene mutation in a pedigree with autosomal dominant Charcot-Marie-Tooth disease]. ( 30692068 )
2019
38
Rigid spine syndrome associated with sensory-motor axonal neuropathy resembling Charcot-Marie-Tooth disease is characteristic of Bcl-2-associated athanogene-3 gene mutations even without cardiac involvement. ( 28224639 )
2018
39
Testing overwork weakness in Charcot-Marie-tooth disease: Is it true or false? ( 29693294 )
2018
40
A novel homozygous NDRG1 mutation in a Chinese patient with Charcot-Marie-Tooth disease 4D. ( 29724652 )
2018
41
Motor unit number index correlates with disability in Charcot-Marie-Tooth disease. ( 29729594 )
2018
42
Association of miR-149 polymorphism with onset age and severity in Charcot-Marie-Tooth disease type 1A. ( 29729827 )
2018
43
Pain in Charcot-Marie-Tooth disease: an update. ( 29742248 )
2018
44
Cochlear Implantation in Charcot-Marie-Tooth Disease: Case Report and Review of the Literature. ( 29780422 )
2018
45
Anaesthesia and orphan diseases: anaesthetic management of a patient with X-linked Charcot-Marie-Tooth disease type 1. ( 29870477 )
2018
46
Clinical and genetic investigation in Chinese patients with demyelinating Charcot-Marie-Tooth disease. ( 29896895 )
2018
47
Clinical and genetic diversities of Charcot-Marie-Tooth disease with MFN2 mutations in a large case study. ( 29906321 )
2018
48
Myelinated axons fail to develop properly in a genetically authentic mouse model of Charcot-Marie-Tooth disease type 2E. ( 29940160 )
2018
49
Drosophila Charcot-Marie-Tooth Disease Models. ( 29951817 )
2018
50
HADHB mutations cause infantile-onset axonal Charcot-Marie-Tooth disease: A report of two cases. ( 29956646 )
2018

Variations for Tooth Disease

Expression for Tooth Disease

Search GEO for disease gene expression data for Tooth Disease.

Pathways for Tooth Disease

Pathways related to Tooth Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.81 GJB1 MPZ PMP22

GO Terms for Tooth Disease

Cellular components related to Tooth Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.73 FGD4 GDAP1 HSPB1 HSPB8 LITAF LMNA
2 vacuolar membrane GO:0005774 9.37 MTMR2 SBF2
3 early endosome membrane GO:0031901 9.33 FIG4 LITAF MTMR2
4 myelin sheath GO:0043209 8.96 MPZ
5 axon cytoplasm GO:1904115 8.8 HSPB1 KIF1B NEFL
6 cytoplasm GO:0005737 10.13 EGR2 FGD4 GDAP1 GJB1 HSPB1 HSPB8

Biological processes related to Tooth Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peripheral nervous system development GO:0007422 9.43 EGR2 PMP22
2 phosphatidylinositol metabolic process GO:0046488 9.4 FIG4 MTMR2
3 mitochondrial fusion GO:0008053 9.37 GDAP1 MFN2
4 negative regulation of endocytosis GO:0045806 9.32 LRSAM1 MTMR2
5 peripheral nervous system myelin maintenance GO:0032287 9.26 NDRG1 SH3TC2
6 myelination GO:0042552 9.26 EGR2 MPZ PMP22 SBF2
7 negative regulation of myelination GO:0031642 9.16 FIG4 MTMR2
8 myelin assembly GO:0032288 8.8 FIG4 MTMR2 PMP22

Molecular functions related to Tooth Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-3-phosphatase activity GO:0004438 8.62 FIG4 MTMR2

Sources for Tooth Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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