Aliases & Classifications for Tooth Disease

MalaCards integrated aliases for Tooth Disease:

Name: Tooth Disease 12 15 17
Tooth Diseases 44 72
Tooth Disorders 43

Classifications:



External Ids:

Disease Ontology 12 DOID:1091
MeSH 44 D014076
SNOMED-CT 68 72722003
UMLS 72 C0040435

Summaries for Tooth Disease

MedlinePlus : 43 What are teeth? Your teeth are made of a hard, bonelike material. There are four parts: Enamel, your tooth's hard surface Dentin, the hard yellow part under the enamel Cementum, the hard tissue that covers the root and keeps your teeth in place Pulp, the soft connective tissue in the center of your tooth. It contains nerves and blood vessels. You need your teeth for many activities that you may take for granted. These include eating, speaking and even smiling. What are tooth disorders? There are many different problems that can affect your teeth, including Tooth decay - damage to a tooth's surface, which can lead to cavities Abscess - a pocket of pus, caused by a tooth infection Impacted tooth - a tooth did not erupt (break through the gum) when it should have. It is usually wisdom teeth that are impacted, but it can sometimes happen to other teeth. Misaligned teeth (malocclusion) Tooth injuries such as broken or chipped teeth What causes tooth disorders? The causes of tooth disorders varies, depending on the problem. Sometimes the cause is not taking good care of your teeth. In other cases, you may have been born with the problem or the cause is an accident. What are the symptoms of tooth disorders? The symptoms can vary, depending on the problem. Some of the more common symptoms include Abnormal color or shape of the tooth Tooth pain Worn-down teeth How are tooth disorders diagnosed? Your dentist will ask about your symptoms, look at your teeth, and probe them with dental instruments. In some cases, you may need dental x-rays. What are the treatments for tooth disorders? The treatment will depend on the problem. Some common treatments are Fillings for cavities Root canals for cavities or infections that affect the pulp (inside of the tooth) Extractions (pulling teeth) for teeth that are impacted and causing problems or are too damaged to be fixed. You may also have a tooth or teeth pulled because of overcrowding in your mouth. Can tooth disorders be prevented? The main thing that you can do to prevent tooth disorders is to take good care of your teeth: Brush your teeth twice a day with a fluoride toothpaste Clean between your teeth every day with floss or another type of between-the-teeth cleaner Limit sugary snacks and drinks Don't smoke or chew tobacco See your dentist or oral health professional regularly

MalaCards based summary : Tooth Disease, also known as tooth diseases, is related to charcot-marie-tooth disease, axonal, type 2a1 and charcot-marie-tooth disease, axonal, type 2j, and has symptoms including halitosis, snoring and toothache. An important gene associated with Tooth Disease is SH3TC2 (SH3 Domain And Tetratricopeptide Repeats 2), and among its related pathways/superpathways is Neural Crest Differentiation. The drugs Ketamine and Folic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and brain, and related phenotypes are no effect and Increased gamma-H2AX phosphorylation

Related Diseases for Tooth Disease

Diseases related to Tooth Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 518)
# Related Disease Score Top Affiliating Genes
1 charcot-marie-tooth disease, axonal, type 2a1 35.1 MFN2 KIF1B
2 charcot-marie-tooth disease, axonal, type 2j 35.1 MPZ KIF1B
3 charcot-marie-tooth disease, axonal, type 2i 35.1 MPZ KIF1B
4 charcot-marie-tooth disease, x-linked dominant, 1 35.0 PMP22 MPZ GJB1
5 charcot-marie-tooth disease, type 4b1 35.0 SBF2 MTMR2 GDAP1
6 charcot-marie-tooth disease, type 4b2 35.0 SBF2 MTMR2 GDAP1
7 charcot-marie-tooth disease, axonal, type 2q 35.0 MPZ EGR2
8 charcot-marie-tooth disease, type 4a 35.0 SBF2 MTMR2 GDAP1
9 charcot-marie-tooth disease, demyelinating, type 4f 35.0 SBF2 MTMR2 GDAP1
10 charcot-marie-tooth disease, axonal, type 2d 34.9 PMP22 MPZ KIF1B GJB1
11 charcot-marie-tooth disease, type 4b3 34.9 SBF2 MTMR2 GDAP1
12 charcot-marie-tooth disease, demyelinating, type 1f 34.9 PMP22 NEFL MPZ GJB1
13 charcot-marie-tooth disease, type 4j 34.9 SBF2 MTMR2 FIG4
14 charcot-marie-tooth disease type 2a 34.7 MFN2 KIF1B
15 charcot-marie-tooth disease, axonal, type 2b 34.7 PMP22 MPZ KIF1B GJB1 EGR2
16 charcot-marie-tooth disease, type 4d 34.6 SH3TC2 NDRG1 MFN2 GJB1 GDAP1
17 charcot-marie-tooth disease, axonal, type 2k 34.6 MFN2 KIF1B HSPB8 GDAP1
18 charcot-marie-tooth disease, axonal, type 2f 34.6 MPZ KIF1B HSPB1 GJB1
19 charcot-marie-tooth disease, x-linked recessive, 3 34.5 HSPB8 GJB1
20 charcot-marie-tooth disease, demyelinating, type 1b 34.5 PMP22 MTMR2 MPZ KIF1B GJB1 EGR2
21 charcot-marie-tooth disease, axonal, type 2l 34.2 MPZ KIF1B HSPB8 HSPB1
22 neuropathy, hereditary motor and sensory, russe type 34.2 SH3TC2 NDRG1 EGR2
23 charcot-marie-tooth disease, demyelinating, type 1c 34.2 PMP22 NEFL MPZ LITAF KIF1B GJB1
24 charcot-marie-tooth disease, demyelinating, type 1a 34.1 PMP22 MTMR2 MPZ MFN2 KIF1B GJB1
25 charcot-marie-tooth disease, demyelinating, type 1d 34.0 PMP22 NDRG1 MTMR2 MPZ KIF1B GJB1
26 roussy-levy hereditary areflexic dystasia 34.0 PMP22 MPZ
27 hereditary motor and sensory neuropathy, type iic 33.7 NDRG1 MPZ MFN2 KIF1B GJB1 GDAP1
28 charcot-marie-tooth disease and deafness 33.7 SH3TC2 PMP22 MTMR2 MPZ MFN2 LITAF
29 charcot-marie-tooth disease, axonal, type 2e 33.4 SBF2 PMP22 NEFL MTMR2 MPZ MFN2
30 charcot-marie-tooth hereditary neuropathy 33.3 PMP22 MPZ
31 foot drop 33.0 PMP22 MPZ
32 hypertrophic neuropathy of dejerine-sottas 32.9 SH3TC2 PMP22 MTMR2 MPZ LITAF KIF1B
33 neuropathy, hereditary, with liability to pressure palsies 31.9 PMP22 MTMR2 MPZ MFN2 LITAF KIF1B
34 polyneuropathy 31.7 PMP22 MPZ GDAP1
35 neuropathy 31.7 SBF2 PMP22 MPZ MFN2 GJB1 GDAP1
36 axonal neuropathy 31.6 PMP22 MFN2 LMNA GDAP1
37 charcot-marie-tooth neuropathy type 2a 31.3 MFN2 KIF1B
38 neuromuscular disease 31.0 PMP22 MPZ LMNA HSPB8
39 early-onset glaucoma 30.7 SBF2 MTMR2
40 charcot-marie-tooth disease 30.6 SH3TC2 SBF2 PMP22 NEFL NDRG1 MTMR2
41 peripheral nervous system disease 30.5 SH3TC2 PMP22 NEFL MTMR2 MPZ MFN2
42 amyotrophic neuralgia 30.5 PMP22 KIF1B GJB1
43 sensory peripheral neuropathy 30.5 PMP22 NDRG1 MTMR2 MPZ MFN2 LITAF
44 cauda equina syndrome 30.3 PMP22 EGR2
45 chronic inflammatory demyelinating polyradiculoneuropathy 30.1 PMP22 MPZ
46 amyotrophic lateral sclerosis 1 29.9 NEFL HSPB8 HSPB1 FIG4
47 charcot-marie-tooth disease, axonal, type 2b1 12.7
48 charcot-marie-tooth disease, axonal, type 2b2 12.7
49 charcot-marie-tooth disease, type 4h 12.7
50 charcot-marie-tooth disease, dominant intermediate b 12.7

Graphical network of the top 20 diseases related to Tooth Disease:



Diseases related to Tooth Disease

Symptoms & Phenotypes for Tooth Disease

UMLS symptoms related to Tooth Disease:


halitosis, snoring, toothache, poor dentition

GenomeRNAi Phenotypes related to Tooth Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 EGR2 FGD4 FIG4 GDAP1 GJB1 HSPB1
2 Increased gamma-H2AX phosphorylation GR00053-A 9.56 EGR2 GJB1 HSPB1 LMNA MPZ NDRG1

MGI Mouse Phenotypes related to Tooth Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.33 EGR2 FGD4 FIG4 GDAP1 GJB1 KIF1B
2 homeostasis/metabolism MP:0005376 10.13 EGR2 GDAP1 GJB1 HSPB1 HSPB8 KIF1B
3 cellular MP:0005384 10.07 EGR2 GDAP1 GJB1 HSPB1 HSPB8 LITAF
4 mortality/aging MP:0010768 9.97 EGR2 FIG4 GJB1 HSPB8 KIF1B LMNA
5 limbs/digits/tail MP:0005371 9.86 EGR2 FIG4 GDAP1 KIF1B LMNA MED25
6 muscle MP:0005369 9.56 FIG4 HSPB8 KIF1B LMNA MFN2 NDRG1
7 nervous system MP:0003631 9.55 EGR2 FGD4 FIG4 GDAP1 GJB1 KIF1B

Drugs & Therapeutics for Tooth Disease

Drugs for Tooth Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 97)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
2
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
3 Micronutrients Phase 4
4 Trace Elements Phase 4
5 Antioxidants Phase 4
6 Vitamins Phase 4
7 Protective Agents Phase 4
8 Nutrients Phase 4
9 Analgesics Phase 4
10 Anesthetics, Intravenous Phase 4
11 Excitatory Amino Acid Antagonists Phase 4
12 Anesthetics, General Phase 4
13 Anesthetics, Dissociative Phase 4
14 Excitatory Amino Acids Phase 4
15 Vitamin B9 Phase 4
16 Folate Phase 4
17 Vitamin B Complex Phase 4
18 Alpha-lipoic Acid Phase 4
19 Thioctic Acid Phase 4
20
Ibuprofen Approved Phase 3 15687-27-1 3672
21
Caffeine Approved Phase 3 58-08-2 2519
22
Acetylcarnitine Approved, Investigational Phase 2, Phase 3 3040-38-8 7045767
23
Vitamin C Approved, Nutraceutical Phase 2, Phase 3 50-81-7 54670067 5785
24 Neurotransmitter Agents Phase 3
25 Central Nervous System Stimulants Phase 3
26 Analgesics, Non-Narcotic Phase 3
27 Cyclooxygenase Inhibitors Phase 3
28 Purinergic P1 Receptor Antagonists Phase 3
29 Anti-Inflammatory Agents, Non-Steroidal Phase 3
30 Phosphodiesterase Inhibitors Phase 3
31 Antirheumatic Agents Phase 3
32 Nootropic Agents Phase 2, Phase 3
33 carnitine Phase 2, Phase 3
34 Pharmaceutical Solutions Phase 3
35 Hematinics Phase 2, Phase 3
36 Neuroprotective Agents Phase 2, Phase 3
37 Epoetin alfa Phase 2, Phase 3 113427-24-0
38
Mexiletine Approved, Investigational Phase 2 31828-71-4 4178
39
Coenzyme Q10 Approved, Investigational, Nutraceutical Phase 1, Phase 2 303-98-0 5281915
40
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
41 Ubiquinone Phase 1, Phase 2
42 Calcium, Dietary Phase 2
43 4-des-dimethylaminotetracycline Phase 1, Phase 2
44 HIV Protease Inhibitors Phase 1, Phase 2
45
protease inhibitors Phase 1, Phase 2
46 Matrix Metalloproteinase Inhibitors Phase 1, Phase 2
47 Ulipristal acetate Phase 2 126784-99-4
48 Contraceptive Agents Phase 2
49
Ethanol Approved 64-17-5 702
50
Iodine Approved, Investigational 7553-56-2 807

Interventional clinical trials:

(show top 50) (show all 103)
# Name Status NCT ID Phase Drugs
1 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
2 Effect of Racemic Ketamine on Pain in Females and Males After Surgical Removal of Third Molars Completed NCT00232492 Phase 4 Placebo males;Ketamine 0,1 mg/kg males;Ketamine 0,3 mg/kg males;Ketamine 0,5 mg/kg males;Placebo females;Ketamine 0,1 mg/kg females;Ketamine 0,3 mg/kg females;Ketamine 0,5 mg/kg females
3 The Association of Alpha Lipoic Acid to the Median Nerve Decompression in the Carpal Tunnel Syndrome: a Randomized Controlled Trial. Completed NCT01895621 Phase 4
4 Lidocaine and Triamcinolone vs Saline Trigger Point Injection for Treatment of Chronic Abdominal Wall Pain Withdrawn NCT02748395 Phase 4 Triamcinolone;Lidocaine
5 A Multicenter Study to Evaluate the Effects on Charcot−Marie−Tooth Neuropathy Type 1A of a Composite Treadmill, Stretching and Proprioceptive Exercise (TreSPE) Rehabilitation Program. Unknown status NCT01289704 Phase 2, Phase 3
6 A Randomized, Placebo-controlled, Double Masked 120 Subject "Futility Design" Clinical Trial of Ascorbic Acid Treatment of Charcot Marie Tooth Disease Type 1A. Completed NCT00484510 Phase 2, Phase 3 Ascorbic acid (Vitamin C);placebo
7 International, Multi-center, Randomized, Double-blind, Placebo-controlled Phase III Study Assessing in Parallel Groups the Efficacy and Safety of 2 Doses of PXT3003 in Patients With Charcot-Marie-Tooth Disease Type 1A Treated 15 Months Completed NCT02579759 Phase 3 PXT3003 dose 1;PXT3003 dose 2;placebo
8 A Single-centre, Double-blind, Randomised, Two-stage, Parallel-group Study to Assess the Efficacy and Safety of the Fixed Dose Combination of Ibuprofen 400 mg and Caffeine 100 mg Versus Ibuprofen 400 mg, Caffeine 100 mg and Placebo in Patients With Postoperative Dental Pain Completed NCT01929031 Phase 3 ibuprofen + caffeine;ibuprofen;ibuprofen;caffeine;ibuprofen + caffeine;placebo;placebo;caffeine;ibuprofen;ibuprofen + caffeine
9 Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome; a Randomized Control Trial. Completed NCT02141035 Phase 2, Phase 3 Acetyl-l-carnitine;placebo
10 International, Multi-center, Open Label, 9-month Follow-up Extension Study Assessing the Long-term Safety and Tolerability of PXT3003 in Patients With Charcot-Marie-Tooth Disease Type 1A Recruiting NCT03023540 Phase 3 PXT3003
11 Recombinant Human Erythropoietin (r-HuEPO) in the Prevention of Neurologic Sequelae From Malignant Spinal Cord Compression: a Multi-Center, Placebo-Controlled, Phase 2 Randomized Study Terminated NCT00220675 Phase 2, Phase 3 Erythropoietin infusion
12 SERENDEM : MD1003 in Patients Suffering From Demyelinating Neuropathies, an Open Label Pilot Study Unknown status NCT02967679 Phase 1, Phase 2 MD1003
13 A Phase II, Randomized, Placebo-controlled Trial of the Safety, Efficacy, Pharmacodynamics and Pharmacokinetics of PXT3003 in Patients With Charcot-Marie-Tooth Disease Type 1A. Completed NCT01401257 Phase 2 PXT3003 Low dose;PXT3003 Intermediate Dose;PXT3003 High Dose
14 Mexiletine for Muscle Cramps in Charcot Marie Tooth Disease Completed NCT02561702 Phase 2 Mexiletine
15 Effects of Coenzyme Q10 (CoQ10) on Subjects With Charcot-Marie-Tooth Disease (CMT):A Double Blind, Randomized, Controlled Trial With an Open Label Follow-up Study Completed NCT00541164 Phase 1, Phase 2 Coenzyme Q10
16 Phase 2 Study of Ascorbic Acid Treatment in Charcot-Marie-Tooth Type 1A Completed NCT00271635 Phase 2 Placebo;ascorbic acid
17 Neuropathy Along the Median Nerve: Etiology of Symptoms Associated With the Carpal Tunnel Syndrome, a Preliminary Study Completed NCT00634738 Phase 1, Phase 2
18 A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of ACE-083 in Patients With Charcot-Marie-Tooth Disease Types 1 and X Recruiting NCT03124459 Phase 2 ACE-083;Placebo
19 An Open-Label Extension Study to Evaluate the Long-Term Effects of ACE-083 in Patients With Facioscapulohumeral Muscular Dystrophy (FSHD) Previously Enrolled in Study A083-02 and in Patients With Charcot-Marie Tooth (CMT) Disease Types 1 and X Previously Enrolled in Study A083-03 Recruiting NCT03943290 Phase 2 ACE-083
20 The Influence of Pronator Teres Release in the Treatment of Median Nerve Compression Neuropathy: A Randomized Prospective Study Recruiting NCT01562860 Phase 2
21 A Randomized Controlled Clinical Trial of Regenerative Protocols to Treat Immature Necrotic Teeth Active, not recruiting NCT01827098 Phase 2
22 Phase I/IIa Trial Evaluating scAAV1.tMCK.NTF3 for Treatment of Charcot-Marie-Tooth Neuropathy Type 1A (CMT1A) Not yet recruiting NCT03520751 Phase 1, Phase 2 scAAV1.tMCK.NTF3
23 A Randomized, Double-Blind, Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of FLX-787-ODT for Treatment of Muscle Cramps in Adult Subjects With Charcot-Marie-Tooth Disease Terminated NCT03254199 Phase 2 FLX-787-ODT (orally disintegrating tablet);Placebo ODT
24 LONG-TERM EFFECTS TOLERANCE AND THE Ulipristal Acetate IN DISEASE Charcot-MARIE-TOOTH TYPE OF 1A Terminated NCT02600286 Phase 2 EllaOne;EllaOne placebo
25 Correlation Between Clinical and Electrophysiological Phenotypes in a Population of Patients With Neuropathy Charcot-Marie-Tooth Disease Type 1A Unknown status NCT01750710
26 Development of the Charcot-Marie-Tooth Disease Infant Scale (CMTInfS) for Infants With CMT Unknown status NCT02979145
27 Evaluation of the Analgesic Efficiency of the Transcutaneous Neurostimulation in the Charcot Syndrome Marie Tooth on the Pains of Lower Limbs Unknown status NCT01918826
28 Clinical Trial of Safety and Efficacy of the Medical Item Collagen Plates With Hydroxyapol Inducing Angiogenesis, "Nukleostim", for Bone Tissue Regeneration Unknown status NCT02293031
29 Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using Platelet-rich Fibrin : A Pilot Randomized Controlled Trial Unknown status NCT02801552
30 Muscle Oxygenation Modification During Effort in 4 Groups of Neuromuscular Diseases Compared to Healthy Controls, and Mitochondrial Function and Phenotype Assessment Unknown status NCT02789059
31 Clinical and Genetic Features of Familial Neuropathy Completed NCT00149045
32 Development and Validation of a Disability Severity Index for Charcot Marie Tooth Disease Completed NCT01455623
33 Survey of Current Management of Orthopaedic Complications in Charcot Marie Tooth Disease Patients Completed NCT02001038
34 Disability Severity Scale (DSI) and Hereditary Motor and Sensory Neuropathy Overall Disability Scale (HMSN-R-ODS) Completed NCT02194010
35 A Prospective Randomized-controlled Evaluation of Nanotite and Osseotite Surfaced Implant Performance in Graduate Student Programs Completed NCT00726063
36 A Prospective, Multicenter, Randomized Multicenter Study of Short Implants Used to Obviate the Need for Sinus Augmentation: an Assessment of Clinical Outcomes and Resource Allocation. Completed NCT00725049
37 An Analysis of the Symptomatic Domains Most Relevant to Charcot Marie Tooth Neuropathy (CMT) Patients Completed NCT02429947
38 MRI of the Brachial Plexus and Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Assessment of DTI-derived Measurements at 3.0-T Completed NCT03460951
39 Noninvasive Assessment of Neuromuscular Disease Using Electrical Impedance Completed NCT02011204
40 A Prospective, Randomized-Controlled, Multicenter Study of NanoTite Implants Placed Into Fresh Sinus Lift Augmentation Sites Completed NCT00713206
41 Performance and Tolerability of a New Medical Device Coating Gel for the Temporary Relief of Teething Symptoms: a Randomized, Open Label, Parallel-group, Multicentre Study Completed NCT03423784
42 Patient Reported Outcomes Measures (PROM) in Carpal Tunnel Therapies in Patients With Inherited Neuropathies Completed NCT02788734
43 A Prospective, Observational Study of Immediate Loading Cases Using Osseotite Certain Tapered Implants Completed NCT01529762
44 BALTiC Study: A Feasibility Analysis of Home Based BALance Training in People With Charcot-Marie-Tooth Disease Completed NCT02982343
45 A Prospective Randomized-controlled Study of the Effect of Surface Topographies on Implant Integration Rates and Clinical Success Completed NCT01529801
46 A Prospective Randomized-controlled Evaluation of the Osseotite Certain Tapered Prevail Implant for the Preservation of Crestal Bone Completed NCT01529775
47 Prospective Randomized-controlled Study of the Integration Success of Osseotite Implants Placed With Different Insertion Procedures Completed NCT01529736
48 Clinical Evaluation Between Zirconia Crowns and Stainless Steel Crowns in Primary Molars Teeth Completed NCT03067337
49 Radiographic Progression of Infiltrated Caries Lesions In-vivo Completed NCT01496456
50 A Prospective Randomized-Controlled Evaluation of an Implant System With a Novel Abutment Attachment Design for the Preservation of Crestal Bone Completed NCT01529879

Search NIH Clinical Center for Tooth Disease

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Camphor
CAMPHOR CRYSTALS
CAMPHOR GUM
CAMPHOR,MONOBROMATED

Cochrane evidence based reviews: tooth diseases

Genetic Tests for Tooth Disease

Anatomical Context for Tooth Disease

MalaCards organs/tissues related to Tooth Disease:

41
Bone, Testes, Brain, Spinal Cord, Skin, Skeletal Muscle, Liver

Publications for Tooth Disease

Articles related to Tooth Disease:

(show top 50) (show all 2963)
# Title Authors PMID Year
1
Electric brushes improve outcomes in caregiver-assisted oral hygiene. 17
31343536 2019
2
Six-month performance of restorations produced with the ethanol-wet-bonding technique: a randomized trial. 17
31269116 2019
3
Study protocol of the cost-effectiveness comparison of two preventive methods in the incidence of caries: A randomized, controlled clinical trial. 17
31348316 2019
4
Charcot-Marie-Tooth 2F (Hsp27 mutations): A review. 38
31212070 2019
5
Compound heterozygous mutations of SH3TC2 in Charcot-Marie-Tooth disease type 4C patients. 38
31227790 2019
6
Three novel mutations in a group of Chinese patients with X-linked Charcot-Marie-Tooth disease. 38
31323543 2019
7
LRSAM1 variants and founder effect in French families with ataxic form of Charcot-Marie-Tooth type 2. 38
30996334 2019
8
Balance impairment in pediatric charcot-marie-tooth disease. 38
31026080 2019
9
CNS phenotype in X linked Charcot- Marie-Tooth disease. 38
30518545 2019
10
What system controls balance in children with charcot-marie-tooth disease? 38
31228266 2019
11
Disease Modeling and Therapeutic Strategies in CMT2A: State of the Art. 38
30830587 2019
12
Phrenic nerve involvement and respiratory muscle weakness in patients with Charcot-Marie-Tooth disease 1A. 38
31393643 2019
13
Novel mutation in the periaxin gene causal to Charcot-Marie-Tooth disease type 4F. 38
31426691 2019
14
Clinical Reasoning: Pes cavus and neuropathy: Think beyond Charcot-Marie-Tooth disease. 38
31427497 2019
15
CNTNAP1 Mutations in an Adult with Charcot Marie Tooth Disease. 38
31397905 2019
16
ATP1A1 mutations cause intermediate Charcot-Marie-Tooth disease. 38
31373411 2019
17
Hearing loss in inherited peripheral neuropathies: Molecular diagnosis by NGS in a French series. 38
31393079 2019
18
A novel mutation in PRPS1 gene causes X-linked Charcot-Marie-Tooth disease-5. 38
31434166 2019
19
Mice with an autosomal dominant Charcot-Marie-Tooth type 2O disease mutation in both dynein alleles display severe moto-sensory phenotypes. 38
31427617 2019
20
Genetic spectrum and clinical profiles in a southeast Chinese cohort of Charcot-Marie-Tooth disease. 38
31372974 2019
21
Junctophilins emerge as novel therapeutic targets. 38
30825194 2019
22
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases. 38
31415174 2019
23
Follistatin-based ligand trap ACE-083 induces localized hypertrophy of skeletal muscle with functional improvement in models of neuromuscular disease. 38
31388039 2019
24
Mutations in C1orf194, encoding a calcium regulator, cause dominant Charcot-Marie-Tooth disease. 38
31199454 2019
25
Genomic Integrity Safeguards Self-Renewal in Embryonic Stem Cells. 38
31390555 2019
26
Data on the effects of Charcot-Marie-Tooth disease type 2N-associated AARS missense mutation (Arg329-to-His) on the cell biological properties. 38
31194127 2019
27
Peripheral myelin protein 22 modulates store-operated calcium channel activity, providing insights into Charcot-Marie-Tooth disease etiology. 38
31213528 2019
28
Gene replacement therapy after neuropathy onset provides therapeutic benefit in a model of CMT1X. 38
31411673 2019
29
A Sporadic Case of Charcot-Marie-Tooth Disease Type 2 with Left Vocal Fold Palsy due to Mitofusin 2 Mutation. 38
30996168 2019
30
Trigeminal Neuralgia and Charcot-Marie-Tooth Disease: An Intriguing Association. Lessons From a Large Family Case Report and Review of Literature. 38
31222744 2019
31
Severe Consequences of SAC3/FIG4 Phosphatase Deficiency to Phosphoinositides in Patients with Charcot-Marie-Tooth Disease Type-4J. 38
31313076 2019
32
Successful treatment of nasopharyngeal cancer using radiotherapy with concurrent cetuximab in a patient with Charcot-Marie-Tooth disease. 38
31308183 2019
33
A very mild phenotype of Charcot-Marie-Tooth disease type 4H caused by two novel mutations in FGD4. 38
31152969 2019
34
A novel mutation in the GARS gene in a Malian family with Charcot-Marie-Tooth disease. 38
31173493 2019
35
Charcot-Marie-Tooth disease and related disorders: an evolving landscape. 38
31343428 2019
36
A multicenter retrospective study of charcot-marie-tooth disease type 4B (CMT4B) associated with mutations in myotubularin-related proteins (MTMRs). 38
31070812 2019
37
A Novel Mutation in MARS in a Patient with Charcot-Marie-Tooth Disease, Axonal, Type 2U with Congenital Onset. 38
31356216 2019
38
Neuroinflammation in the pathogenesis of axonal Charcot-Marie-Tooth disease caused by lack of GDAP1. 38
31271761 2019
39
[A genotyping study of 13 cases of early-onset Charcot-Marie-Tooth disease]. 38
31315766 2019
40
Aminosalicylic acid reduces ER stress and Schwann cell death induced by MPZ mutations. 38
31059078 2019
41
Foot Function Index: A Promising Questionnaire for Individuals With Charcot-Marie-Tooth Disease Type 1A. 38
31255638 2019
42
New novel mutations in Brazilian families with X-linked Charcot-Marie-Tooth disease. 38
31119804 2019
43
Mutation spectrum of Charcot-Marie-Tooth disease among the Han Chinese in Taiwan. 38
31211173 2019
44
Surgical outcomes of cavovarus foot deformity in children with Charcot-Marie-Tooth disease. 38
31122830 2019
45
Falls in paediatric Charcot-Marie-Tooth disease: a 6-month prospective cohort study. 38
30104392 2019
46
POLG mutations presenting as Charcot-Marie-Tooth disease. 38
30843307 2019
47
X-linked Charcot-Marie-Tooth Disease Presenting with Stuttering Stroke-like Symptoms. 38
31220874 2019
48
A novel family with axonal Charcot-Marie-Tooth disease caused by a mutation in the EGR2 gene. 38
30843326 2019
49
Influence of Training Models at 3,900-m Altitude on the Physiological Response and Performance of a Professional Wheelchair Athlete: A Case Study. 38
29927887 2019
50
Prevalence of Charcot-Marie-Tooth disease across the lifespan: a population-based epidemiological study. 38
31203252 2019

Variations for Tooth Disease

Expression for Tooth Disease

Search GEO for disease gene expression data for Tooth Disease.

Pathways for Tooth Disease

Pathways related to Tooth Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.81 PMP22 MPZ GJB1

GO Terms for Tooth Disease

Cellular components related to Tooth Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.73 SBF2 NEFL NDRG1 MTMR2 MFN2 LRSAM1
2 vacuolar membrane GO:0005774 9.37 SBF2 MTMR2
3 early endosome membrane GO:0031901 9.33 MTMR2 LITAF FIG4
4 myelin sheath GO:0043209 8.96 MPZ
5 axon cytoplasm GO:1904115 8.8 NEFL KIF1B HSPB1
6 cytoplasm GO:0005737 10.13 SBF2 NEFL NDRG1 MTMR2 LRSAM1 LITAF

Biological processes related to Tooth Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peripheral nervous system development GO:0007422 9.43 PMP22 EGR2
2 phosphatidylinositol metabolic process GO:0046488 9.4 MTMR2 FIG4
3 mitochondrial fusion GO:0008053 9.37 MFN2 GDAP1
4 negative regulation of endocytosis GO:0045806 9.32 MTMR2 LRSAM1
5 peripheral nervous system myelin maintenance GO:0032287 9.26 SH3TC2 NDRG1
6 myelination GO:0042552 9.26 SBF2 PMP22 MPZ EGR2
7 negative regulation of myelination GO:0031642 9.16 MTMR2 FIG4
8 myelin assembly GO:0032288 8.8 PMP22 MTMR2 FIG4

Molecular functions related to Tooth Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-3-phosphatase activity GO:0004438 8.62 MTMR2 FIG4

Sources for Tooth Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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46 MGI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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