MCID: TTH007
MIFTS: 31

Tooth Erosion

Categories: Oral diseases

Aliases & Classifications for Tooth Erosion

MalaCards integrated aliases for Tooth Erosion:

Name: Tooth Erosion 12 54 43 15 71
Generalized Erosions 71
Generalized Erosion 12
Erosion, Localized 71
Localized Erosion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2498
ICD9CM 34 521.3
MeSH 43 D014077
SNOMED-CT 67 82212003
ICD10 32 K03.2
UMLS 71 C0040436 C1456164 C1456165

Summaries for Tooth Erosion

MalaCards based summary : Tooth Erosion, also known as generalized erosions, is related to dentine erosion and dental caries. An important gene associated with Tooth Erosion is GPI (Glucose-6-Phosphate Isomerase). The drugs Calcium and Calcium, Dietary have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and salivary gland.

Related Diseases for Tooth Erosion

Diseases related to Tooth Erosion via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 dentine erosion 29.0 TUFT1 PLA2G15 MTF1 GPI
2 dental caries 27.9 TUFT1 STATH ENAM DSPP CA6 AMELX
3 enamel erosion 26.3 TYRO3 STATH SMARCA4 SMARCA2 SLC38A5 SHF
4 congenital erosive and vesicular dermatosis 11.1
5 gastroesophageal reflux 10.3
6 dentin caries 10.3 STATH DSPP
7 alpha thalassemia-x-linked intellectual disability syndrome 10.2 SMARCA4 SMARCA2
8 schimke immunoosseous dysplasia 10.2 SMARCA4 SMARCA2
9 autosomal recessive hypophosphatemic rickets 10.2 STATH DSPP
10 dental pulp necrosis 10.2 DSPP AMELX
11 eating disorder 10.2
12 dental pulp calcification 10.1 ENAM DSPP
13 dental pulp disease 10.1 DSPP AMELX
14 rhabdoid cancer 10.1 SMARCA4 SMARCA2
15 tooth resorption 10.1 DSPP AMELX
16 hypercementosis 10.1 ENAM DSPP
17 anorexia nervosa 10.1
18 bulimia nervosa 10.1
19 gingival disease 10.1 SMARCA4 SMARCA2
20 neurilemmomatosis 10.0 SMARCA4 SMARCA2
21 amelogenesis imperfecta, type ic 10.0 ENAM AMELX
22 dentin dysplasia 10.0 ENAM DSPP
23 amelogenesis imperfecta, type iiia 9.9 ENAM AMELX
24 asthma 9.9
25 hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome 9.9
26 alcohol use disorder 9.9
27 juvenile rheumatoid arthritis 9.9
28 epilepsy, familial temporal lobe, 1 9.8 SMARCA4 SMARCA2
29 dental fluorosis 9.8 ENAM DSPP AMELX
30 amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2 9.8 TUFT1 AMELX
31 root caries 9.7 STATH SMARCA4 SMARCA2 GPI DSPP
32 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.7
33 sensorineural hearing loss 9.7
34 spondyloarthropathy 9.7
35 erosive pustular dermatosis of the scalp 9.7
36 enamel caries 9.6 STATH FAM187A ENAM AMELX
37 hypocalcified amelogenesis imperfecta 9.5 TUFT1 ENAM DSPP
38 amelogenesis imperfecta, type ie 9.4 TUFT1 ENAM AMELX
39 amelogenesis imperfecta 9.2 TUFT1 ENAM DSPP AMELX
40 tooth agenesis 9.2 TUFT1 ENAM DSPP AMELX
41 teeth hard tissue disease 8.9 TUFT1 STATH ENAM DSPP AMELX

Graphical network of the top 20 diseases related to Tooth Erosion:



Diseases related to Tooth Erosion

Symptoms & Phenotypes for Tooth Erosion

Drugs & Therapeutics for Tooth Erosion

Drugs for Tooth Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
2 Calcium, Dietary Phase 4
3 Caseins Phase 4
4 Chelating Agents Phase 4
5 Hormones Phase 4
6 Anti-Infective Agents, Local Phase 2, Phase 3
7 Tin Fluorides Phase 2, Phase 3
8
Tin Phase 2, Phase 3 7440-31-5
9
Esomeprazole Approved, Investigational Phase 1, Phase 2 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
10 Gastrointestinal Agents Phase 1, Phase 2
11 Anti-Ulcer Agents Phase 1, Phase 2
12 Antacids Phase 1, Phase 2
13 Proton Pump Inhibitors Phase 1, Phase 2
14
Calcium carbonate Approved, Investigational 471-34-1
15 Orange Approved
16
acetic acid Approved 64-19-7 176
17
Nicotine Approved 54-11-5 942 89594
18
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
19
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
20 sodium fluoride Approved 7681-49-4
21 Olaflur Experimental 6818-37-7
22 Fluorophosphate
23
Retinol acetate 127-47-9 10245972
24 Anti-Bacterial Agents
25 insulin
26 Insulin, Globin Zinc
27 Anti-Infective Agents
28 Dermatologic Agents
29 Keratolytic Agents
30 Antifungal Agents
31 Fluorides
32 Listerine
33 Protective Agents
34 Cariostatic Agents
35 Pharmaceutical Solutions
36
Arginine Investigational, Nutraceutical 74-79-3 6322

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 In Situ Effect of Casein Phosphopeptide--amorphous Calcium Phosphate on the Surface Microhardness of Human Enamel Subjected to in Vivo Acid Attacks Completed NCT03426150 Phase 4 CPP-ACP;Placebos
2 A Randomized, Examiner Blind, Crossover, in Situ Erosion Study to Investigate the Efficacy of an Experimental Dentifrice in Remineralization of Previously Softened Enamel Compared to a Placebo Dentifrice Completed NCT03296072 Phase 2, Phase 3 0.254% w/w sodium fluoride and 5% KNO3;0.454% w/w stannous fluoride;5% KNO3
3 Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion Completed NCT01128972 Phase 2 Sodium fluoride;Sodium monoflurophosphate;Sterile water
4 In Vivo Quantification of Dental Demineralisation Using Optical Coherence Tomography Before and After Double-blind, Randomised Treatment With Esomeprazole or Placebo of Patients With Dental Erosions Completed NCT00564330 Phase 1, Phase 2 Esomeprazole;Placebo
5 Exploratory Evaluation of an Experimental Fluoride Dentifrice Formulation Using an in Situ Remineralization/Fluoride Uptake Model Completed NCT00752089 Phase 2 NaF/ KNO3/isopentane Dentifrice;NaF/KNO3 Dentifrice;NaF Dentifrice
6 Preliminary Clinical Study of Ultrasound to Measure Enamel Thickness Completed NCT01622920 Phase 1
7 Dental Erosion in Patients With Gastro-oesophageal Reflux Unknown status NCT02775149
8 Study to Investigate the Initial Stages of Enamel Erosion in Vivo Completed NCT02533466
9 The Effects of Mouthguard With Desensitizing Toothpaste in Reducing Dental Hypersensitivity in Swimmers : A Randomized Clinical Trial Completed NCT03515902
10 Intra-oral Kinetics of Fluoride Containing Dentifrices in a Modified Saliva Clearance Study Completed NCT02548156
11 Pilot Study to Investigate the Reparative Effect of a Two Phase Oral Care Product Containing SMFP and NaF on Enamel Against a Dietary Acid Exposure Utilising an Impression Technique to Capture in Vivo Images of Teeth Completed NCT02676219
12 Influence of Gender Specific Differences of Saliva Composition on the Development of Dental Erosion - an In-situ Study Completed NCT02780973
13 The Effect of Vinegar Consumption on Visceral Fat and Blood Glucose Concentration Completed NCT03577834
14 A Placebo Controlled Study to Evaluate the Effectiveness of Experimental Foaming Gel Toothpastes Using an In-situ Erosion Remineralization Model Completed NCT01657903 Sodium Fluoride;Potassium nitrate
15 Relationship and Pathophysiology of Gastroesophageal Reflux and Dental/Periodontal Disease Completed NCT01167543
16 Survey of the Collective 16s rRNA Genes From Bacterial Populations From Exercising and Non-exercising Participants Completed NCT02639455
17 Evaluation of an Oral Health Intervention Program for Children With Congenital Heart Defects Completed NCT03311438
18 Gastro-oesophageal Reflux in Oligosymptomatic Patients With Dental Erosion: a Longitudinal Study With pH-impedance Monitoring Recruiting NCT02087345
19 The Characterisation of Therapeutic Radiation-induced Caries; the Histopathological, Ultrastructural and Microbial Changes Affecting Its Prevention and Treatment. Recruiting NCT03397823
20 Clinical Evaluation of Ultrathin Occlusal Veneers for the Treatment of Severe Dental Erosion Active, not recruiting NCT03112278
21 Non-Carious Cervical Lesions Restored With Different Etching Methods and New Injectable Composite: One Year Clinical Follow-Up Active, not recruiting NCT04095520
22 Preventing Early Childhood Obesity, Part 1: Family Spirit Nurture, 3-9 Months Active, not recruiting NCT03101943
23 Maintaining Oral Health With Bio-products: a Randomized, Cross-over, in Situ Study Not yet recruiting NCT04033263
24 Prophylactic Effect of a CANDIDA Mouthwash, Containing the Curolox™ Peptide: a Mono-centre, Not-controlled. Not Blinded, Not-randmised in Situ Study Withdrawn NCT02308436

Search NIH Clinical Center for Tooth Erosion

Cochrane evidence based reviews: tooth erosion

Genetic Tests for Tooth Erosion

Anatomical Context for Tooth Erosion

MalaCards organs/tissues related to Tooth Erosion:

40
Testes, Heart, Salivary Gland, Pituitary, Temporal Lobe

Publications for Tooth Erosion

Articles related to Tooth Erosion:

(show top 50) (show all 175)
# Title Authors PMID Year
1
Diagnosis and dental treatment of a young adult patient with gastroesophageal reflux: a case report with 2-year follow-up. 54 61
12238695 2002
2
Use of new scratch test and tensile test for evaluation of bond strength of selfadhesive flowable resin composite for repair of artificial tooth erosion. 61
31932547 2020
3
Evaluation of Change in Microhardness by Application of MI Varnish on Primary Tooth Enamel, Affected by Use of Frequently Prescribed Paediatric Syrups: An In Vitro Study. 61
32038891 2020
4
Eroded enamel rehardening using two intraoral appliances designs in different times of salivary exposure. 61
31824592 2019
5
Hybridization drives genetic erosion in sympatric desert fishes of western North America. 61
31431737 2019
6
A Probabilistic Model of the Economic Risk to Britain's Railway Network from Bridge Scour During Floods. 61
31318475 2019
7
Adverse effects of respiratory disease medicaments and tooth brushing on teeth: A scanning electron microscopy, X-ray fluorescence and infrared spectroscopy study. 61
31150562 2019
8
Cheek tooth erosion in male babirusa (genus Babyrousa). 61
31474523 2019
9
In vitro evaluation of the effects of frequently prescribed pediatric drugs on the microhardness of permanent tooth enamel. 61
31274250 2019
10
Minimally Invasive Adhesive Rehabilitation for a Patient With Tooth Erosion: Seven-year Follow-up. 61
30142039 2019
11
100% Fruit Juice and Dental Health: A Systematic Review of the Literature. 61
31355175 2019
12
Dental erosion caused by Granny Smith apples: An evidence-based case report and 1-year follow-up. 61
30214743 2018
13
The effect of aspartame and pH changes on the erosive potential of cola drinks in bovine enamel: An in vitro study. 61
30386528 2018
14
Anti-erosive effect of calcium carbonate suspensions. 61
30305876 2018
15
Effect of an experimental mouth rinse containing NaF and TiF4 on tooth erosion and abrasion in situ. 61
29621568 2018
16
Variation on Molecular Structure, Crystallinity, and Optical Properties of Dentin Due to Nd:YAG Laser and Fluoride Aimed at Tooth Erosion Prevention. 61
29389868 2018
17
Fast monitoring of tooth erosion caused by medicaments used in the treatment of respiratory diseases by ATR-FTIR and μ-EDXRF analysis. 61
28942528 2017
18
Eating disorder professionals' perceptions of oral health knowledge. 61
26449876 2017
19
Development of Epigallocatechin-3-gallate-Encapsulated Nanohydroxyapatite/Mesoporous Silica for Therapeutic Management of Dentin Surface. 61
28703572 2017
20
Protocol for measurement of enamel loss from brushing with an anti-erosive toothpaste after an acidic episode. 61
28682285 2017
21
Conservative, Functional, and Esthetic Rehabilitation of Severe Palatal Erosion (Class IV) Using Modified Dahl Approach. 61
28459247 2017
22
Neutralizing salivary pH by mouthwashes after an acidic challenge. 61
26616243 2017
23
A Giant-Cell Lesion with Cellular Cannibalism in the Mandible: Case Report and Review of Brown Tumors in Hyperparathyroidism. 61
28280638 2017
24
Restorative Rehabilitation of a Patient with Dental Erosion. 61
28828189 2017
25
Prevalence and Associated Factors of Tooth Erosion in 8 -12-Year-Old Brazilian Schoolchildren. 61
28872983 2017
26
Effect of toothpastes containing different NaF concentrations or a SnF2/NaF combination on root dentine erosive lesions, in vitro. 61
27957274 2016
27
Oral and Physical Manifestations of Anorexia and Bulimia Nervosa. 61
30549518 2016
28
A Dental Hygienist's and Therapist's Guide to the Management of Tooth Erosion. 61
28826465 2016
29
Simultaneous wireless assessment of intra-oral pH and temperature. 61
27263031 2016
30
Using (1)(0)Be cosmogenic isotopes to estimate erosion rates and landscape changes during the Plio-Pleistocene in the Cradle of Humankind, South Africa. 61
27343770 2016
31
Analysis of dental erosion induced by different beverages and validity of equipment for identifying early dental erosion, in vitro study. 61
27427133 2016
32
Determination of Prevalence of Dental Erosion in 12 - 14 Years School Children and Its Relationship with Dietary Habits. 61
27504542 2016
33
Impact of diet on tooth erosion. 61
27339233 2016
34
The prevalence of dental erosion in 5-year-old preschoolers in Sharjah, United Arab Emirates. 61
27095899 2016
35
Impact of CO2 laser and stannous fluoride on primary tooth erosion. 61
26886587 2016
36
[Tooth erosion - a multidisciplinary approach]. 61
27000809 2016
37
Acid Rather Than Nonacid Reflux Burden Is a Predictor of Tooth Erosion. 61
26230904 2016
38
Amazonian delicacy tucupi is as erosive as a cola-based soft drink. 61
26547020 2016
39
Effect of a Single Application of TiF4 Varnish versus Daily Use of a Low-Concentrated TiF4/NaF Solution on Tooth Erosion Prevention in vitro. 61
27577928 2016
40
Medication-related dental erosion: a review. 61
26448149 2015
41
The effect of enamel proteins on erosion. 61
26468660 2015
42
Diet influenced tooth erosion prevalence in children and adolescents: Results of a meta-analysis and meta-regression. 61
26057086 2015
43
Soft drinks and in vitro dental erosion. 61
26147165 2015
44
Effect of endurance training on dental erosion, caries, and saliva. 61
24917276 2015
45
Oral manifestations in gastroesophageal reflux disease. 61
25945775 2015
46
The effect of antacid on salivary pH in patients with and without dental erosion after multiple acid challenges. 61
26087576 2015
47
Estimated prevalence of erosive tooth wear in permanent teeth of children and adolescents: an epidemiological systematic review and meta-regression analysis. 61
25446243 2015
48
TiF4 and NaF varnishes as anti-erosive agents on enamel and dentin erosion progression in vitro. 61
25760263 2015
49
Influence of various acidic beverages on tooth erosion. Evaluation by a new method. 61
26035729 2015
50
Synthesis of carboxylic block copolymers via reversible addition fragmentation transfer polymerization for tooth erosion prevention. 61
25248611 2014

Variations for Tooth Erosion

Expression for Tooth Erosion

Search GEO for disease gene expression data for Tooth Erosion.

Pathways for Tooth Erosion

GO Terms for Tooth Erosion

Cellular components related to Tooth Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 TUFT1 STATH PLA2G15 GPI ENAM DSPP
2 SWI/SNF complex GO:0016514 9.26 SMARCA4 SMARCA2
3 nBAF complex GO:0071565 8.96 SMARCA4 SMARCA2
4 npBAF complex GO:0071564 8.62 SMARCA4 SMARCA2

Biological processes related to Tooth Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP-dependent chromatin remodeling GO:0043044 9.16 SMARCA4 SMARCA2
2 biomineral tissue development GO:0031214 9.02 TUFT1 STATH ENAM DSPP AMELX
3 response to cadmium ion GO:0046686 8.96 MTF1 GPI

Molecular functions related to Tooth Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity, acting on acid anhydrides GO:0016817 9.16 SMARCA4 SMARCA2
2 hydroxyapatite binding GO:0046848 8.96 STATH AMELX
3 structural constituent of tooth enamel GO:0030345 8.92 TUFT1 STATH ENAM AMELX

Sources for Tooth Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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