Aliases & Classifications for Tooth Erosion

MalaCards integrated aliases for Tooth Erosion:

Name: Tooth Erosion 12 55 44 15 72
Generalized Erosions 72
Generalized Erosion 12
Erosion, Localized 72
Localized Erosion 12


External Ids:

Disease Ontology 12 DOID:2498
ICD9CM 35 521.3
MeSH 44 D014077
SNOMED-CT 68 82212003
ICD10 33 K03.2
UMLS 72 C0040436 C1456164 C1456165

Summaries for Tooth Erosion

MalaCards based summary : Tooth Erosion, also known as generalized erosions, is related to dental caries and dentine erosion. An important gene associated with Tooth Erosion is GPI (Glucose-6-Phosphate Isomerase), and among its related pathways/superpathways are BRCA1 Pathway and Transcription Ligand-dependent activation of the ESR1/SP pathway. The drugs Calcium and Calcium, Dietary have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and salivary gland, and related phenotype is growth/size/body region.

Related Diseases for Tooth Erosion

Graphical network of the top 20 diseases related to Tooth Erosion:

Diseases related to Tooth Erosion

Symptoms & Phenotypes for Tooth Erosion

MGI Mouse Phenotypes related to Tooth Erosion:

# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.1 GPI MTF1 RASIP1 SMARCA2 SMARCA4 TUFT1

Drugs & Therapeutics for Tooth Erosion

Drugs for Tooth Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
2 Calcium, Dietary Phase 4
3 Caseins Phase 4
4 Hormones Phase 4
5 Chelating Agents Phase 4
6 Anti-Infective Agents, Local Phase 2, Phase 3
Tin Phase 2, Phase 3 7440-31-5
8 Tin Fluorides Phase 2, Phase 3
Esomeprazole Approved, Investigational Phase 1, Phase 2 119141-88-7, 161796-78-7, 161973-10-0 9568614 4594
10 Gastrointestinal Agents Phase 1, Phase 2
11 Antacids Phase 1, Phase 2
12 Anti-Ulcer Agents Phase 1, Phase 2
13 Proton Pump Inhibitors Phase 1, Phase 2
Calcium carbonate Approved, Investigational 471-34-1
15 Orange Approved
Nicotine Approved 54-11-5 942 89594
acetic acid Approved 64-19-7 176
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
20 sodium fluoride Approved 7681-49-4
21 Olaflur Experimental 6818-37-7
22 arginine
23 Fluorophosphate
24 Anti-Infective Agents
25 insulin
26 Insulin, Globin Zinc
27 Anti-Bacterial Agents
Retinol acetate 127-47-9 10245972
29 Antifungal Agents
30 Keratolytic Agents
31 Dermatologic Agents
32 Cariostatic Agents
33 Listerine
34 Fluorides
35 Protective Agents
36 Pharmaceutical Solutions

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 In Situ Effect of Casein Phosphopeptide--amorphous Calcium Phosphate on the Surface Microhardness of Human Enamel Subjected to in Vivo Acid Attacks Completed NCT03426150 Phase 4 CPP-ACP;Placebos
2 A Randomized, Examiner Blind, Crossover, in Situ Erosion Study to Investigate the Efficacy of an Experimental Dentifrice in Remineralization of Previously Softened Enamel Compared to a Placebo Dentifrice Completed NCT03296072 Phase 2, Phase 3 0.254% w/w sodium fluoride and 5% KNO3;0.454% w/w stannous fluoride;5% KNO3
3 Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion Completed NCT01128972 Phase 2 Sodium fluoride;Sodium monoflurophosphate;Sterile water
4 In Vivo Quantification of Dental Demineralisation Using Optical Coherence Tomography Before and After Double-blind, Randomised Treatment With Esomeprazole or Placebo of Patients With Dental Erosions Completed NCT00564330 Phase 1, Phase 2 Esomeprazole;Placebo
5 Exploratory Evaluation of an Experimental Fluoride Dentifrice Formulation Using an in Situ Remineralization/Fluoride Uptake Model Completed NCT00752089 Phase 2 NaF/ KNO3/isopentane Dentifrice;NaF/KNO3 Dentifrice;NaF Dentifrice
6 Preliminary Clinical Study of Ultrasound to Measure Enamel Thickness Completed NCT01622920 Phase 1
7 Dental Erosion in Patients With Gastro-oesophageal Reflux Unknown status NCT02775149
8 Study to Investigate the Initial Stages of Enamel Erosion in Vivo Completed NCT02533466
9 The Effects of Mouthguard With Desensitizing Toothpaste in Reducing Dental Hypersensitivity in Swimmers : A Randomized Clinical Trial Completed NCT03515902
10 Pilot Study to Investigate the Reparative Effect of a Two Phase Oral Care Product Containing SMFP and NaF on Enamel Against a Dietary Acid Exposure Utilising an Impression Technique to Capture in Vivo Images of Teeth Completed NCT02676219
11 Intra-oral Kinetics of Fluoride Containing Dentifrices in a Modified Saliva Clearance Study Completed NCT02548156
12 Influence of Gender Specific Differences of Saliva Composition on the Development of Dental Erosion - an In-situ Study Completed NCT02780973
13 Relationship and Pathophysiology of Gastroesophageal Reflux and Dental/Periodontal Disease Completed NCT01167543
14 A Placebo Controlled Study to Evaluate the Effectiveness of Experimental Foaming Gel Toothpastes Using an In-situ Erosion Remineralization Model Completed NCT01657903 Sodium Fluoride;Potassium nitrate
15 Survey of the Collective 16s rRNA Genes From Bacterial Populations From Exercising and Non-exercising Participants Completed NCT02639455
16 Evaluation of an Oral Health Intervention Program for Children With Congenital Heart Defects Completed NCT03311438
17 Gastro-oesophageal Reflux in Oligosymptomatic Patients With Dental Erosion: a Longitudinal Study With pH-impedance Monitoring Recruiting NCT02087345
18 The Characterisation of Therapeutic Radiation-induced Caries; the Histopathological, Ultrastructural and Microbial Changes Affecting Its Prevention and Treatment. Recruiting NCT03397823
19 The Effect of Vinegar Consumption on Visceral Fat and Blood Glucose Concentration Active, not recruiting NCT03577834
20 Clinical Evaluation of Ultrathin Occlusal Veneers for the Treatment of Severe Dental Erosion Active, not recruiting NCT03112278
21 Preventing Early Childhood Obesity, Part 1: Family Spirit Nurture, 3-9 Months Active, not recruiting NCT03101943
22 Maintaining Oral Health With Bio-products: a Randomized, Cross-over, in Situ Study Not yet recruiting NCT04033263
23 Prophylactic Effect of a CANDIDA Mouthwash, Containing the Curolox™ Peptide: a Mono-centre, Not-controlled. Not Blinded, Not-randmised in Situ Study Withdrawn NCT02308436

Search NIH Clinical Center for Tooth Erosion

Cochrane evidence based reviews: tooth erosion

Genetic Tests for Tooth Erosion

Anatomical Context for Tooth Erosion

MalaCards organs/tissues related to Tooth Erosion:

Heart, Testes, Salivary Gland, Pituitary

Publications for Tooth Erosion

Articles related to Tooth Erosion:

(show top 50) (show all 171)
# Title Authors PMID Year
Diagnosis and dental treatment of a young adult patient with gastroesophageal reflux: a case report with 2-year follow-up. 9 38
12238695 2002
Adverse effects of respiratory disease medicaments and tooth brushing on teeth: A scanning electron microscopy, X-ray fluorescence and infrared spectroscopy study. 38
31150562 2019
Hybridization drives genetic erosion in sympatric desert fishes of western North America. 38
31431737 2019
A Probabilistic Model of the Economic Risk to Britain's Railway Network from Bridge Scour During Floods. 38
31318475 2019
In vitro evaluation of the effects of frequently prescribed pediatric drugs on the microhardness of permanent tooth enamel. 38
31274250 2019
Minimally Invasive Adhesive Rehabilitation for a Patient With Tooth Erosion: Seven-year Follow-up. 38
30142039 2019
100% Fruit Juice and Dental Health: A Systematic Review of the Literature. 38
31355175 2019
Dental erosion caused by Granny Smith apples: An evidence-based case report and 1-year follow-up. 38
30214743 2018
The effect of aspartame and pH changes on the erosive potential of cola drinks in bovine enamel: An in vitro study. 38
30386528 2018
Anti-erosive effect of calcium carbonate suspensions. 38
30305876 2018
Effect of an experimental mouth rinse containing NaF and TiF4 on tooth erosion and abrasion in situ. 38
29621568 2018
Variation on Molecular Structure, Crystallinity, and Optical Properties of Dentin Due to Nd:YAG Laser and Fluoride Aimed at Tooth Erosion Prevention. 38
29389868 2018
Fast monitoring of tooth erosion caused by medicaments used in the treatment of respiratory diseases by ATR-FTIR and μ-EDXRF analysis. 38
28942528 2017
Eating disorder professionals' perceptions of oral health knowledge. 38
26449876 2017
Development of Epigallocatechin-3-gallate-Encapsulated Nanohydroxyapatite/Mesoporous Silica for Therapeutic Management of Dentin Surface. 38
28703572 2017
Protocol for measurement of enamel loss from brushing with an anti-erosive toothpaste after an acidic episode. 38
28682285 2017
Conservative, Functional, and Esthetic Rehabilitation of Severe Palatal Erosion (Class IV) Using Modified Dahl Approach. 38
28459247 2017
Neutralizing salivary pH by mouthwashes after an acidic challenge. 38
26616243 2017
A Giant-Cell Lesion with Cellular Cannibalism in the Mandible: Case Report and Review of Brown Tumors in Hyperparathyroidism. 38
28280638 2017
Restorative Rehabilitation of a Patient with Dental Erosion. 38
28828189 2017
Prevalence and Associated Factors of Tooth Erosion in 8 -12-Year-Old Brazilian Schoolchildren. 38
28872983 2017
Effect of toothpastes containing different NaF concentrations or a SnF2/NaF combination on root dentine erosive lesions, in vitro. 38
27957274 2016
Oral and Physical Manifestations of Anorexia and Bulimia Nervosa. 38
30549518 2016
A Dental Hygienist's and Therapist's Guide to the Management of Tooth Erosion. 38
28826465 2016
Simultaneous wireless assessment of intra-oral pH and temperature. 38
27263031 2016
Using (1)(0)Be cosmogenic isotopes to estimate erosion rates and landscape changes during the Plio-Pleistocene in the Cradle of Humankind, South Africa. 38
27343770 2016
Determination of Prevalence of Dental Erosion in 12 - 14 Years School Children and Its Relationship with Dietary Habits. 38
27504542 2016
Analysis of dental erosion induced by different beverages and validity of equipment for identifying early dental erosion, in vitro study. 38
27427133 2016
Impact of diet on tooth erosion. 38
27339233 2016
The prevalence of dental erosion in 5-year-old preschoolers in Sharjah, United Arab Emirates. 38
27095899 2016
Impact of CO2 laser and stannous fluoride on primary tooth erosion. 38
26886587 2016
[Tooth erosion - a multidisciplinary approach]. 38
27000809 2016
Acid Rather Than Nonacid Reflux Burden Is a Predictor of Tooth Erosion. 38
26230904 2016
Effect of a Single Application of TiF4 Varnish versus Daily Use of a Low-Concentrated TiF4/NaF Solution on Tooth Erosion Prevention in vitro. 38
27577928 2016
Amazonian delicacy tucupi is as erosive as a cola-based soft drink. 38
26547020 2016
The effect of enamel proteins on erosion. 38
26468660 2015
Medication-related dental erosion: a review. 38
26448149 2015
Diet influenced tooth erosion prevalence in children and adolescents: Results of a meta-analysis and meta-regression. 38
26057086 2015
Soft drinks and in vitro dental erosion. 38
26147165 2015
Effect of endurance training on dental erosion, caries, and saliva. 38
24917276 2015
Oral manifestations in gastroesophageal reflux disease. 38
25945775 2015
The effect of antacid on salivary pH in patients with and without dental erosion after multiple acid challenges. 38
26087576 2015
TiF4 and NaF varnishes as anti-erosive agents on enamel and dentin erosion progression in vitro. 38
25760263 2015
Estimated prevalence of erosive tooth wear in permanent teeth of children and adolescents: an epidemiological systematic review and meta-regression analysis. 38
25446243 2015
Influence of various acidic beverages on tooth erosion. Evaluation by a new method. 38
26035729 2015
Synthesis of carboxylic block copolymers via reversible addition fragmentation transfer polymerization for tooth erosion prevention. 38
25248611 2014
A method for monitoring enamel erosion using laser irradiated surfaces and optical coherence tomography. 38
25147133 2014
Restorative management using hybrid ceramic of a patient with severe tooth erosion from swimming: a clinical report. 38
25352965 2014
The Basic Erosive Wear Examination (BEWE) applied retrospectively to two studies. 38
24306679 2014
Complex esthetic and functional rehabilitation with an additive, minimally invasive restorative approach. 38
25188215 2014

Variations for Tooth Erosion

Expression for Tooth Erosion

Search GEO for disease gene expression data for Tooth Erosion.

Pathways for Tooth Erosion

Pathways related to Tooth Erosion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways

GO Terms for Tooth Erosion

Cellular components related to Tooth Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.16 SMARCA4 SMARCA2
2 nBAF complex GO:0071565 8.96 SMARCA4 SMARCA2
3 npBAF complex GO:0071564 8.62 SMARCA4 SMARCA2

Biological processes related to Tooth Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin remodeling GO:0006338 9.26 SMARCA4 SMARCA2
2 biomineral tissue development GO:0031214 9.16 TUFT1 DSPP
3 ATP-dependent chromatin remodeling GO:0043044 8.96 SMARCA4 SMARCA2
4 response to cadmium ion GO:0046686 8.62 MTF1 GPI

Molecular functions related to Tooth Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription coactivator activity GO:0003713 9.33 SMARCA4 SMARCA2 MTF1
2 DNA-dependent ATPase activity GO:0008094 8.96 SMARCA4 SMARCA2
3 hydrolase activity, acting on acid anhydrides GO:0016817 8.62 SMARCA4 SMARCA2

Sources for Tooth Erosion

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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