Aliases & Classifications for Tooth Erosion

MalaCards integrated aliases for Tooth Erosion:

Name: Tooth Erosion 12 56 45 15 74
Generalized Erosions 74
Generalized Erosion 12
Erosion, Localized 74
Localized Erosion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2498
ICD9CM 36 521.3
MeSH 45 D014077
SNOMED-CT 69 82212003
ICD10 34 K03.2

Summaries for Tooth Erosion

MalaCards based summary : Tooth Erosion, also known as generalized erosions, is related to congenital erosive and vesicular dermatosis and gastroesophageal reflux. An important gene associated with Tooth Erosion is GPI (Glucose-6-Phosphate Isomerase), and among its related pathways/superpathways are BRCA1 Pathway and Transcription Ligand-dependent activation of the ESR1/SP pathway. The drugs Calcium and Caseins have been mentioned in the context of this disorder. Affiliated tissues include testes and salivary gland, and related phenotype is growth/size/body region.

Related Diseases for Tooth Erosion

Graphical network of the top 20 diseases related to Tooth Erosion:



Diseases related to Tooth Erosion

Symptoms & Phenotypes for Tooth Erosion

MGI Mouse Phenotypes related to Tooth Erosion:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.1 GPI MTF1 RASIP1 SMARCA2 SMARCA4 TUFT1

Drugs & Therapeutics for Tooth Erosion

Drugs for Tooth Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Approved, Nutraceutical Phase 4,Not Applicable 7440-70-2 271
2 Caseins Phase 4,Not Applicable
3 Hormones Phase 4,Not Applicable
4 Calcium, Dietary Phase 4,Not Applicable
5 Chelating Agents Phase 4
6 sodium fluoride Approved Phase 2, Phase 3,Not Applicable 7681-49-4
7 Fluorides Phase 2, Phase 3,Not Applicable
8 Protective Agents Phase 2, Phase 3,Not Applicable
9 Anti-Infective Agents, Local Phase 2, Phase 3,Not Applicable
10
Tin Phase 2, Phase 3 7440-31-5
11 Listerine Phase 2, Phase 3,Not Applicable
12 Cariostatic Agents Phase 2, Phase 3,Not Applicable
13 Anti-Infective Agents Phase 2, Phase 3,Not Applicable
14 Tin Fluorides Phase 2, Phase 3
15
Esomeprazole Approved, Investigational Phase 1, Phase 2 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
16 Anti-Ulcer Agents Phase 1, Phase 2,Not Applicable
17 Antacids Phase 1, Phase 2,Not Applicable
18 Gastrointestinal Agents Phase 1, Phase 2,Not Applicable
19 Proton Pump Inhibitors Phase 1, Phase 2
20
Hydrocortisone acetate Approved, Vet_approved Not Applicable 50-03-3
21
Hydrocortisone Approved, Vet_approved Not Applicable 50-23-7 5754
22 Orange Approved Not Applicable
23
Nicotine Approved Not Applicable 54-11-5 89594 942
24
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
25
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
26
Calcium Carbonate Approved, Investigational Not Applicable 471-34-1
27
acetic acid Approved Not Applicable 64-19-7 176
28 Olaflur Experimental Not Applicable 6818-37-7
29 Hydrocortisone hemisuccinate Not Applicable
30 Anti-Inflammatory Agents Not Applicable
31 Hydrocortisone-17-butyrate Not Applicable
32 Hydrocortisone 17-butyrate 21-propionate Not Applicable
33 Fluorophosphate Not Applicable
34 Fluorides, Topical
35 Dermatologic Agents Not Applicable
36 Antifungal Agents Not Applicable
37 Keratolytic Agents Not Applicable
38 arginine Not Applicable
39 insulin Not Applicable
40
Retinol acetate Not Applicable 127-47-9 10245972
41 Insulin, Globin Zinc Not Applicable
42 Anti-Bacterial Agents Not Applicable
43 Bone Density Conservation Agents Not Applicable

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Casein Phosphopeptide--amorphous Calcium Phosphate on Human Enamel Subjected to in Vivo Acid Attacks Completed NCT03426150 Phase 4 CPP-ACP;Placebos
2 In Situ Erosion Study to Investigate the Effectiveness of an Experimental Toothpaste Completed NCT03296072 Phase 2, Phase 3 0.254% w/w sodium fluoride and 5% KNO3;0.454% w/w stannous fluoride;5% KNO3
3 Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion Completed NCT01128972 Phase 2 Sodium fluoride;Sodium monoflurophosphate;Sterile water
4 In Vivo Quantification of Dental Demineralisation Using OCT With and Without Esomeprazole Completed NCT00564330 Phase 1, Phase 2 Esomeprazole;Placebo
5 Experimental Dentifrice Remineralization/Fluoride Uptake in an in Situ Model Completed NCT00752089 Phase 2 NaF/ KNO3/isopentane Dentifrice;NaF/KNO3 Dentifrice;NaF Dentifrice
6 Preliminary Clinical Study of Ultrasound to Measure Enamel Thickness Completed NCT01622920 Phase 1
7 Dental Erosion in Patients With Gastro-oesophageal Reflux Unknown status NCT02775149
8 Endoscopic Treatment of Salivary Glands Affected by Sjögren's Syndrome Unknown status NCT02112019 Not Applicable saline;hydrocortisone
9 Influence of Gender Specific Differences of Saliva Composition on the Development of Dental Erosion - an In-situ Study Completed NCT02780973
10 Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion Completed NCT01657903 Not Applicable Sodium Fluoride;Potassium nitrate
11 Pilot Study Utilising an Impression Technique to Capture in Vivo Images of Teeth Completed NCT02676219 Not Applicable
12 Intra Oral Kinetics of Fluoride Containing Dentifrices Completed NCT02548156 Not Applicable
13 In Vivo Investigation of Initial Stages of Enamel Erosion Completed NCT02533466 Not Applicable
14 Relationship and Pathophysiology of Gastroesophageal Reflux and Dental/Periodontal Disease Completed NCT01167543
15 Oral Health Intervention Program for Children With Congenital Heart Defects Completed NCT03311438 Not Applicable
16 Survey of the Collective 16s rRNA Genes From Bacterial Populations From Exercising and Non-exercising Participants Completed NCT02639455 Not Applicable
17 Evaluation of a Low-fluoride Anticaries Toothpaste Completed NCT01094210 Fluorides, Topical
18 Impact of an Oral Health Intervention Completed NCT03921632 Not Applicable
19 Impact of Milk on Erosion/Abrasion of Enamel and Dentin - an in Situ Study Completed NCT01566357 Not Applicable Tooth Mousse;MI Paste Plus;Elmex Erosion Protection
20 Gastro-oesophageal Reflux in Oligosymptomatic Patients With Dental Erosion Recruiting NCT02087345
21 Clinical Evaluation of Ultrathin Occlusal Veneers for the Treatment of Severe Dental Erosion Active, not recruiting NCT03112278 Not Applicable
22 The Effects of Mouthguard and Desensitizing Toothpaste in Reducing Dental Hypersensitivity Active, not recruiting NCT03515902 Not Applicable
23 The Effect of Vinegar Consumption on Visceral Fat and Blood Glucose Concentration Active, not recruiting NCT03577834 Not Applicable
24 8% L-Arginine/Calcium Carbonate Toothpaste in Comparison to Strontium Acetate Toothpaste for Hypersensitive Dentin Active, not recruiting NCT03068533 Not Applicable
25 Preventing Early Childhood Obesity, Part 1: Family Spirit Nurture, 3-9 Months Active, not recruiting NCT03101943 Not Applicable
26 Use of Low-level Laser Therapy on Children Aged One to Five Years With Energy-protein Malnutrition Enrolling by invitation NCT03355313 Not Applicable
27 Prophylactic Effect of a CANDIDA Mouthwash, Containing the Curolox™ Peptide Withdrawn NCT02308436 Not Applicable

Search NIH Clinical Center for Tooth Erosion

Cochrane evidence based reviews: tooth erosion

Genetic Tests for Tooth Erosion

Anatomical Context for Tooth Erosion

MalaCards organs/tissues related to Tooth Erosion:

42
Testes, Salivary Gland

Publications for Tooth Erosion

Articles related to Tooth Erosion:

(show top 50) (show all 62)
# Title Authors Year
1
Minimally Invasive Adhesive Rehabilitation for a Patient With Tooth Erosion: Seven-year Follow-up. ( 30142039 )
2019
2
Variation on Molecular Structure, Crystallinity, and Optical Properties of Dentin Due to Nd:YAG Laser and Fluoride Aimed at Tooth Erosion Prevention. ( 29389868 )
2018
3
Effect of an experimental mouth rinse containing NaF and TiF4 on tooth erosion and abrasion in situ. ( 29621568 )
2018
4
Prevalence and Associated Factors of Tooth Erosion in 8 -12-Year-Old Brazilian Schoolchildren. ( 28872983 )
2017
5
Fast monitoring of tooth erosion caused by medicaments used in the treatment of respiratory diseases by ATR-FTIR and μ-EDXRF analysis. ( 28942528 )
2017
6
Acid Rather Than Nonacid Reflux Burden Is a Predictor of Tooth Erosion. ( 26230904 )
2016
7
Impact of CO2 laser and stannous fluoride on primary tooth erosion. ( 26886587 )
2016
8
Impact of diet on tooth erosion. ( 27339233 )
2016
9
Effect of a Single Application of TiF4 Varnish versus Daily Use of a Low-Concentrated TiF4/NaF Solution on Tooth Erosion Prevention in vitro. ( 27577928 )
2016
10
A Dental Hygienist's and Therapist's Guide to the Management of Tooth Erosion. ( 28826465 )
2016
11
Influence of various acidic beverages on tooth erosion. Evaluation by a new method. ( 26035729 )
2015
12
Diet influenced tooth erosion prevalence in children and adolescents: Results of a meta-analysis and meta-regression. ( 26057086 )
2015
13
Inhibition of tooth erosion by milk containing different fluoride concentrations: an in vitro study. ( 24373857 )
2014
14
Synthesis of carboxylic block copolymers via reversible addition fragmentation transfer polymerization for tooth erosion prevention. ( 25248611 )
2014
15
Restorative management using hybrid ceramic of a patient with severe tooth erosion from swimming: a clinical report. ( 25352965 )
2014
16
Tooth erosion and eating disorders: a systematic review and meta-analysis. ( 25379668 )
2014
17
Gastroesophageal reflux disease and tooth erosion: a cross-sectional observational study. ( 23710307 )
2013
18
Impact of different fluoride concentrations and pH of dentifrices on tooth erosion/abrasion in vitro. ( 23441800 )
2013
19
Prevalence of deciduous tooth erosion in childhood. ( 23506560 )
2013
20
Gastroesophageal reflux disease and tooth erosion. ( 22194748 )
2012
21
Relationship between food habits and tooth erosion occurrence in Malaysian University students. ( 22973138 )
2012
22
Effect of fluoride on tooth erosion around orthodontic brackets. ( 23306238 )
2012
23
Prevalence of tooth erosion and associated factors in 13-16-year old adolescents in Greece. ( 24558548 )
2012
24
Gastroesophageal reflux disease and tooth erosion: SEPAHAN systematic review no. 10. ( 23372604 )
2011
25
Prevalence of tooth erosion and associated factors in 11-14-year-old Brazilian schoolchildren. ( 20726945 )
2011
26
Tooth erosion awareness in a Brazilian dental school. ( 22184602 )
2011
27
Dynamics of tooth erosion in adolescents: a 3-year longitudinal study. ( 19799959 )
2010
28
Tooth erosion with low severity does not impact child oral health-related quality of life. ( 21051891 )
2010
29
Pop-cola acids and tooth erosion: an in vitro, in vivo, electron-microscopic, and clinical report. ( 21151663 )
2010
30
Gastric reflux is a significant causative factor of tooth erosion. ( 19493884 )
2009
31
A longitudinal study of tooth erosion in adolescents indicates that this may be a progressive phenomenon, at least on some tooth sites. ( 19913741 )
2009
32
Rapid and severe tooth erosion from swimming in an improperly chlorinated pool: case report. ( 18538074 )
2008
33
A longitudinal study of tooth erosion in adolescents. ( 18650543 )
2008
34
Acidic beverages increase the risk of in vitro tooth erosion. ( 19083423 )
2008
35
Adhesive restorations, centric relation, and the Dahl principle: minimally invasive approaches to localized anterior tooth erosion. ( 19655550 )
2007
36
The prevalence of tooth erosion in 12-year-old children. ( 15017417 )
2004
37
Tooth erosion caused by chewing aspirin. ( 15354902 )
2004
38
Assessment of a procedure for detecting minute levels of tooth erosion. ( 12892370 )
2003
39
The progression of tooth erosion in a cohort of adolescents of mixed ethnicity. ( 12924985 )
2003
40
Awareness of tooth erosion in 12 year old children and primary care dental practitioners. ( 14696741 )
2003
41
Asthma and tooth erosion. Is there an association? ( 14984048 )
2003
42
Gastroesophageal reflux disease, tooth erosion, and prosthodontic rehabilitation: a clinical report. ( 15061234 )
2003
43
Dahl appliances used for the restorative management of localized anterior tooth erosion. ( 15061336 )
2003
44
Tooth erosion in Ireland. ( 12483794 )
2002
45
Conduct of an algorithm in quantifying simulated palatal surface tooth erosion. ( 11380785 )
2001
46
Tackling tooth erosion. ( 10800232 )
2000
47
Bulimia and tooth erosion. ( 9537733 )
1998
48
Use of resin-bonded ceramic crowns in a bulimic patient with severe tooth erosion. ( 9063223 )
1996
49
Tooth erosion, gastroesophageal reflux, and salivary buffer capacity. ( 7614182 )
1995
50
Tooth erosion: an unusual case. ( 23087989 )
1994

Variations for Tooth Erosion

Expression for Tooth Erosion

Search GEO for disease gene expression data for Tooth Erosion.

Pathways for Tooth Erosion

Pathways related to Tooth Erosion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.87 SMARCA2 SMARCA4
2
Show member pathways
10.47 SMARCA2 SMARCA4

GO Terms for Tooth Erosion

Cellular components related to Tooth Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.16 SMARCA2 SMARCA4
2 nBAF complex GO:0071565 8.96 SMARCA2 SMARCA4
3 npBAF complex GO:0071564 8.62 SMARCA2 SMARCA4

Biological processes related to Tooth Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin remodeling GO:0006338 9.26 SMARCA2 SMARCA4
2 biomineral tissue development GO:0031214 9.16 DSPP TUFT1
3 ATP-dependent chromatin remodeling GO:0043044 8.96 SMARCA2 SMARCA4
4 response to cadmium ion GO:0046686 8.62 GPI MTF1

Molecular functions related to Tooth Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription coactivator activity GO:0003713 9.33 MTF1 SMARCA2 SMARCA4
2 DNA-dependent ATPase activity GO:0008094 8.96 SMARCA2 SMARCA4
3 hydrolase activity, acting on acid anhydrides GO:0016817 8.62 SMARCA2 SMARCA4

Sources for Tooth Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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