Aliases & Classifications for Tooth Erosion

MalaCards integrated aliases for Tooth Erosion:

Name: Tooth Erosion 12 55 44 15 73
Generalized Erosions 73
Generalized Erosion 12
Erosion, Localized 73
Localized Erosion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2498
ICD10 33 K03.2
ICD9CM 35 521.3
MeSH 44 D014077
SNOMED-CT 68 82212003

Summaries for Tooth Erosion

MalaCards based summary : Tooth Erosion, also known as generalized erosions, is related to congenital erosive and vesicular dermatosis and gastroesophageal reflux. An important gene associated with Tooth Erosion is GPI (Glucose-6-Phosphate Isomerase), and among its related pathways/superpathways are BRCA1 Pathway and Transcription Ligand-dependent activation of the ESR1/SP pathway. The drugs Calcium, Dietary and Chelating Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, and related phenotype is growth/size/body region.

Related Diseases for Tooth Erosion

Graphical network of the top 20 diseases related to Tooth Erosion:



Diseases related to Tooth Erosion

Symptoms & Phenotypes for Tooth Erosion

MGI Mouse Phenotypes related to Tooth Erosion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.1 GPI MTF1 RASIP1 SMARCA2 SMARCA4 TUFT1

Drugs & Therapeutics for Tooth Erosion

Drugs for Tooth Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Calcium, Dietary Phase 4,Not Applicable
2 Chelating Agents Phase 4
3 Caseins Phase 4,Not Applicable
4 sodium fluoride Approved Phase 3,Phase 2,Not Applicable 7681-49-4
5 Cariostatic Agents Phase 3,Phase 2,Not Applicable
6 Protective Agents Phase 3,Phase 2,Not Applicable
7 Fluorides Phase 3,Phase 2,Not Applicable
8 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
9 Listerine Phase 3,Phase 2,Not Applicable
10
Tin Phase 3 7440-31-5
11 Tin Fluorides Phase 3
12 Anti-Infective Agents, Local Phase 3,Phase 2,Not Applicable
13
Esomeprazole Approved, Investigational Phase 1, Phase 2 161796-78-7, 119141-88-7 4594 9579578
14 Antacids Phase 1, Phase 2,Not Applicable
15 Anti-Ulcer Agents Phase 1, Phase 2,Not Applicable
16 Proton Pump Inhibitors Phase 1, Phase 2
17 Gastrointestinal Agents Phase 1, Phase 2,Not Applicable
18 Orange Approved Not Applicable
19
Nicotine Approved Not Applicable 54-11-5 942 89594
20
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
21
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
22
Calcium Carbonate Approved, Investigational Not Applicable 471-34-1
23
acetic acid Approved Not Applicable 64-19-7 176
24
Hydrocortisone Approved, Vet_approved Not Applicable 50-23-7 5754
25
Hydrocortisone acetate Approved, Vet_approved Not Applicable 50-03-3
26 Fluorophosphate Not Applicable
27 Fluorides, Topical
28 Olaflur Not Applicable
29 Keratolytic Agents Not Applicable
30 Antifungal Agents Not Applicable
31 Dermatologic Agents Not Applicable
32 arginine Not Applicable
33
Retinol acetate Not Applicable 127-47-9 10245972
34 Insulin, Globin Zinc Not Applicable
35 insulin Not Applicable
36 Bone Density Conservation Agents Not Applicable
37 Hydrocortisone 17-butyrate 21-propionate Not Applicable
38 Hydrocortisone-17-butyrate Not Applicable
39 Anti-Inflammatory Agents Not Applicable
40 Cortisol succinate Not Applicable

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Casein Phosphopeptide--amorphous Calcium Phosphate on Human Enamel Subjected to in Vivo Acid Attacks Completed NCT03426150 Phase 4 CPP-ACP;Placebos
2 In Situ Erosion Study to Investigate the Effectiveness of an Experimental Toothpaste Completed NCT03296072 Phase 3 0.254% w/w sodium fluoride and 5% KNO3;0.454% w/w stannous fluoride;5% KNO3
3 Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion Completed NCT01128972 Phase 2 Sodium fluoride;Sodium monoflurophosphate;Sterile water
4 In Vivo Quantification of Dental Demineralisation Using OCT With and Without Esomeprazole Completed NCT00564330 Phase 1, Phase 2 Esomeprazole;Placebo
5 Experimental Dentifrice Remineralization/Fluoride Uptake in an in Situ Model Completed NCT00752089 Phase 2 NaF/ KNO3/isopentane Dentifrice;NaF/KNO3 Dentifrice;NaF Dentifrice
6 Preliminary Clinical Study of Ultrasound to Measure Enamel Thickness Completed NCT01622920 Phase 1
7 Influence of Gender Specific Differences of Saliva Composition on the Development of Dental Erosion - an In-situ Study Completed NCT02780973
8 Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion Completed NCT01657903 Not Applicable Sodium Fluoride;Potassium nitrate
9 Pilot Study Utilising an Impression Technique to Capture in Vivo Images of Teeth Completed NCT02676219 Not Applicable
10 Intra Oral Kinetics of Fluoride Containing Dentifrices Completed NCT02548156 Not Applicable
11 In Vivo Investigation of Initial Stages of Enamel Erosion Completed NCT02533466 Not Applicable
12 Relationship and Pathophysiology of Gastroesophageal Reflux and Dental/Periodontal Disease Completed NCT01167543
13 Oral Health Intervention Program for Children With Congenital Heart Defects Completed NCT03311438 Not Applicable
14 Survey of the Collective 16s rRNA Genes From Bacterial Populations From Exercising and Non-exercising Participants Completed NCT02639455 Not Applicable
15 Evaluation of a Low-fluoride Anticaries Toothpaste Completed NCT01094210 Fluorides, Topical
16 Impact of Milk on Erosion/Abrasion of Enamel and Dentin - an in Situ Study Completed NCT01566357 Not Applicable Tooth Mousse;MI Paste Plus;Elmex Erosion Protection
17 Gastro-oesophageal Reflux in Oligosymptomatic Patients With Dental Erosion Recruiting NCT02087345
18 Clinical Evaluation of Ultrathin Occlusal Veneers for the Treatment of Severe Dental Erosion Active, not recruiting NCT03112278 Not Applicable
19 The Effects of Mouthguard and Desensitizing Toothpaste in Reducing Dental Hypersensitivity Active, not recruiting NCT03515902 Not Applicable
20 The Effect of Vinegar Consumption on Visceral Fat and Blood Glucose Concentration Active, not recruiting NCT03577834 Not Applicable
21 8% L-Arginine/Calcium Carbonate Toothpaste in Comparison to Strontium Acetate Toothpaste for Hypersensitive Dentin Active, not recruiting NCT03068533 Not Applicable
22 Endoscopic Treatment of Salivary Glands Affected by Sjögren's Syndrome Active, not recruiting NCT02112019 Not Applicable saline;hydrocortisone
23 Preventing Early Childhood Obesity, Part 1: Family Spirit Nurture, 3-9 Months Active, not recruiting NCT03101943 Not Applicable
24 Dental Erosion in Patients With Gastro-oesophageal Reflux Enrolling by invitation NCT02775149
25 Use of Low-level Laser Therapy on Children Aged One to Five Years With Energy-protein Malnutrition Enrolling by invitation NCT03355313 Not Applicable
26 Prophylactic Effect of a CANDIDA Mouthwash, Containing the Curolox™ Peptide Withdrawn NCT02308436 Not Applicable

Search NIH Clinical Center for Tooth Erosion

Cochrane evidence based reviews: tooth erosion

Genetic Tests for Tooth Erosion

Anatomical Context for Tooth Erosion

MalaCards organs/tissues related to Tooth Erosion:

41
Testes

Publications for Tooth Erosion

Articles related to Tooth Erosion:

(show top 50) (show all 62)
# Title Authors Year
1
Variation on Molecular Structure, Crystallinity, and Optical Properties of Dentin Due to Nd:YAG Laser and Fluoride Aimed at Tooth Erosion Prevention. ( 29389868 )
2018
2
Effect of an experimental mouth rinse containing NaF and TiF4 on tooth erosion and abrasion in situ. ( 29621568 )
2018
3
Minimally Invasive Adhesive Rehabilitation for a Patient With Tooth Erosion: Seven-year Follow-up. ( 30142039 )
2018
4
Fast monitoring of tooth erosion caused by medicaments used in the treatment of respiratory diseases by ATR-FTIR and I1-EDXRF analysis. ( 28942528 )
2017
5
Prevalence and Associated Factors of Tooth Erosion in 8 -12-Year-Old Brazilian Schoolchildren. ( 28872983 )
2017
6
A Dental Hygienist's and Therapist's Guide to the Management of Tooth Erosion. ( 28826465 )
2016
7
Impact of diet on tooth erosion. ( 27339233 )
2016
8
Effect of a Single Application of TiF4 Varnish versus Daily Use of a Low-Concentrated TiF4/NaF Solution on Tooth Erosion Prevention in vitro. ( 27577928 )
2016
9
Impact of CO2 laser and stannous fluoride on primary tooth erosion. ( 26886587 )
2016
10
Diet influenced tooth erosion prevalence in children and adolescents: Results of a meta-analysis and meta-regression. ( 26057086 )
2015
11
Acid Rather than Non-Acid Reflux Burden is a Predictor of Tooth Erosion. ( 26230904 )
2015
12
Influence of various acidic beverages on tooth erosion. Evaluation by a new method. ( 26035729 )
2015
13
Synthesis of Carboxylic Block Copolymers via Reversible Addition Fragmentation Transfer Polymerization for Tooth Erosion Prevention. ( 25248611 )
2014
14
Tooth erosion and eating disorders: a systematic review and meta-analysis. ( 25379668 )
2014
15
Restorative management using hybrid ceramic of a patient with severe tooth erosion from swimming: a clinical report. ( 25352965 )
2014
16
Inhibition of tooth erosion by milk containing different fluoride concentrations: An in vitro study. ( 24373857 )
2013
17
Prevalence of deciduous tooth erosion in childhood. ( 23506560 )
2013
18
Gastroesophageal reflux disease and tooth erosion: a cross-sectional observational study. ( 23710307 )
2013
19
Impact of different fluoride concentrations and pH of dentifrices on tooth erosion/abrasion in vitro. ( 23441800 )
2013
20
Relationship between food habits and tooth erosion occurrence in Malaysian University students. ( 22973138 )
2012
21
Prevalence of tooth erosion and associated factors in 13-16-year old adolescents in Greece. ( 24558548 )
2012
22
Effect of fluoride on tooth erosion around orthodontic brackets. ( 23306238 )
2012
23
Gastroesophageal reflux disease and tooth erosion. ( 22194748 )
2012
24
Gastroesophageal reflux disease and tooth erosion: SEPAHAN systematic review no. 10. ( 23372604 )
2011
25
Tooth erosion awareness in a Brazilian dental school. ( 22184602 )
2011
26
Prevalence of tooth erosion and associated factors in 11-14-year-old Brazilian schoolchildren. ( 20726945 )
2011
27
Pop-cola acids and tooth erosion: an in vitro, in vivo, electron-microscopic, and clinical report. ( 21151663 )
2010
28
Dynamics of tooth erosion in adolescents: a 3-year longitudinal study. ( 19799959 )
2010
29
Tooth erosion with low severity does not impact child oral health-related quality of life. ( 21051891 )
2010
30
A longitudinal study of tooth erosion in adolescents indicates that this may be a progressive phenomenon, at least on some tooth sites. ( 19913741 )
2009
31
Gastric reflux is a significant causative factor of tooth erosion. ( 19493884 )
2009
32
Acidic beverages increase the risk of in vitro tooth erosion. ( 19083423 )
2008
33
A longitudinal study of tooth erosion in adolescents. ( 18650543 )
2008
34
Rapid and severe tooth erosion from swimming in an improperly chlorinated pool: case report. ( 18538074 )
2008
35
Adhesive restorations, centric relation, and the Dahl principle: minimally invasive approaches to localized anterior tooth erosion. ( 19655550 )
2007
36
The prevalence of tooth erosion in 12-year-old children. ( 15017417 )
2004
37
Tooth erosion caused by chewing aspirin. ( 15354902 )
2004
38
Awareness of tooth erosion in 12 year old children and primary care dental practitioners. ( 14696741 )
2003
39
The progression of tooth erosion in a cohort of adolescents of mixed ethnicity. ( 12924985 )
2003
40
Gastroesophageal reflux disease, tooth erosion, and prosthodontic rehabilitation: a clinical report. ( 15061234 )
2003
41
Dahl appliances used for the restorative management of localized anterior tooth erosion. ( 15061336 )
2003
42
Assessment of a procedure for detecting minute levels of tooth erosion. ( 12892370 )
2003
43
Asthma and tooth erosion. Is there an association? ( 14984048 )
2003
44
Tooth erosion in Ireland. ( 12483794 )
2002
45
Conduct of an algorithm in quantifying simulated palatal surface tooth erosion. ( 11380785 )
2001
46
Tackling tooth erosion. ( 10800232 )
2000
47
Bulimia and tooth erosion. ( 9537733 )
1998
48
Use of resin-bonded ceramic crowns in a bulimic patient with severe tooth erosion. ( 9063223 )
1996
49
Tooth erosion, gastroesophageal reflux, and salivary buffer capacity. ( 7614182 )
1995
50
Tooth erosion: an unusual case. ( 23087989 )
1994

Variations for Tooth Erosion

Expression for Tooth Erosion

Search GEO for disease gene expression data for Tooth Erosion.

Pathways for Tooth Erosion

Pathways related to Tooth Erosion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.87 SMARCA2 SMARCA4
2
Show member pathways
10.47 SMARCA2 SMARCA4

GO Terms for Tooth Erosion

Cellular components related to Tooth Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.16 SMARCA2 SMARCA4
2 nBAF complex GO:0071565 8.96 SMARCA2 SMARCA4
3 npBAF complex GO:0071564 8.62 SMARCA2 SMARCA4

Biological processes related to Tooth Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin remodeling GO:0006338 9.26 SMARCA2 SMARCA4
2 biomineral tissue development GO:0031214 9.16 DSPP TUFT1
3 ATP-dependent chromatin remodeling GO:0043044 8.96 SMARCA2 SMARCA4
4 response to cadmium ion GO:0046686 8.62 GPI MTF1

Molecular functions related to Tooth Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription coactivator activity GO:0003713 9.33 MTF1 SMARCA2 SMARCA4
2 DNA-dependent ATPase activity GO:0008094 8.96 SMARCA2 SMARCA4
3 hydrolase activity, acting on acid anhydrides GO:0016817 8.62 SMARCA2 SMARCA4

Sources for Tooth Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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