Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect
Release Notes Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: TTH008
MIFTS: 38

Tooth Resorption

Categories: Oral diseases
Data Licensing
For inquiries, contact:
[email protected]
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Tooth Resorption

About this section

MalaCards integrated aliases for Tooth Resorption:

Name: Tooth Resorption 11 53 43 14 71 75

Classifications:

MalaCards categories:
Anatomical: Oral diseases
See all MalaCards categories (disease lists)
ICD10: 31


External Ids:

Disease Ontology 11 DOID:13240
ICD9CM 34 521.4
MeSH 43 D014091
SNOMED-CT 68 70931000
ICD10 31 K03.3
UMLS 71 C0040451
Sources

Summaries for Tooth Resorption

About this section

MalaCards based summary: Tooth Resorption is related to hypercementosis and teeth, supernumerary, and has symptoms including toothache An important gene associated with Tooth Resorption is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are Extracellular matrix organization and Vitamin D receptor pathway. The drug Mometasone furoate has been mentioned in the context of this disorder. Affiliated tissues include bone and eye, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia: 75 Resorption of the root of the tooth, or root resorption, is the progressive loss of dentin and cementum... more...
Sources

Related Diseases for Tooth Resorption

About this section

Diseases related to Tooth Resorption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 hypercementosis 30.7 IBSP DSPP CTSK AMELX AMBN
2 teeth, supernumerary 30.3 RUNX2 DSPP
3 periodontitis, chronic 30.1 TNFSF11 IL1B
4 root resorption 29.9 TNFSF11 TNFRSF11A SPP1 RUNX2 IL1B DSPP
5 periodontitis 29.5 TNFSF11 SERPINA3 RUNX2 IL1B CTSK BGLAP
6 ankylosis 29.4 TNFSF11 SPP1 SP7 RUNX2 IBSP BMP2
7 dental pulp necrosis 29.4 TNFSF11 RUNX2 IBSP DSPP CEMP1 BMP2
8 rickets 29.3 SPP1 PTH IBSP DSPP CALCA BGLAP
9 gingival recession 29.2 TNFSF11 IL1B DSPP CEMP1 BMP2 AMELX
10 pulp degeneration 10.3 DSPP AMBN
11 malignant giant cell tumor 10.3 TNFSF11 ACP5
12 dentine erosion 10.3 AMELX AMBN
13 femoral cancer 10.3 TNFSF11 ACP5
14 amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2 10.3 AMELX AMBN
15 enamel caries 10.3 AMELX AMBN
16 tooth erosion 10.2 DSPP AMELX AMBN
17 root caries 10.2 DSPP AMELX AMBN
18 tooth ankylosis 10.2 SPP1 AMBN
19 osteogenesis imperfecta, type xxi 10.2 SPP1 BGLAP
20 multicentric carpotarsal osteolysis syndrome 10.2 TNFSF11 IBSP BGLAP
21 dental fluorosis 10.2 BGLAP AMELX AMBN
22 telangiectatic osteogenic sarcoma 10.2 TNFSF11 CALCA
23 amelogenesis imperfecta, type ib 10.2 AMELX AMBN
24 acute pericementitis 10.2 TNFSF11 IL1B
25 osteofibrous dysplasia 10.2 SPP1 BGLAP
26 bone osteosarcoma 10.2 TNFSF11 RUNX2 BGLAP
27 plantar fasciitis 10.1 CALCA BMP2
28 congenital epulis 10.1 SERPINA3 AMELX
29 saethre-chotzen syndrome 10.1 RUNX2 IBSP BGLAP
30 tetanic cataract 10.1 PTH CALCA
31 ossification of the posterior longitudinal ligament of spine 10.1 RUNX2 BMP2 BGLAP
32 exostosis 10.1 RUNX2 BMP2 BGLAP
33 metaphyseal dysplasia 10.1 RUNX2 PTH ACP5
34 hemiplegia 10.1 CALCA BGLAP ACP5
35 substernal goiter 10.1 PTH CALCA
36 osteopetrosis, autosomal dominant 2 10.1 TNFSF11 CTSK BGLAP ACP5
37 pycnodysostosis 10.1 TNFSF11 CTSK BGLAP ACP5
38 hair whorl 10.1
39 kohler's disease 10.1 PTH CALCA
40 geotrichosis 10.1 DSPP CEMP1
41 isthmus cancer 10.1 PTH CALCA
42 osteoblastoma 10.1 TNFSF11 PTH BGLAP
43 suppurative periapical periodontitis 10.1 IL1B DSPP AMBN
44 hypervitaminosis d 10.1 PTH CALCA
45 hypercalcemia, infantile, 1 10.1 PTH CALCA
46 paget disease of bone 5, juvenile-onset 10.1 TNFSF11 TNFRSF11A CALCA
47 type c thymoma 10.1 SERPINA3 CEMP1
48 fibrosarcomatous osteosarcoma 10.1 SERPINA3 BGLAP
49 chronic apical periodontitis 10.1 TNFSF11 RUNX2 IL1B
50 chondroblastic osteosarcoma 10.1 SERPINA3 BGLAP

Graphical network of the top 20 diseases related to Tooth Resorption:



Diseases related to Tooth Resorption
Sources

Symptoms & Phenotypes for Tooth Resorption

About this section

UMLS symptoms related to Tooth Resorption:


toothache

MGI Mouse Phenotypes related to Tooth Resorption:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 AMELX BGLAP BMP2 CALCA CTSK DSPP
2 growth/size/body region MP:0005378 10.25 AMBN AMELX BMP2 CTSK DSPP IBSP
3 immune system MP:0005387 10.2 ACP5 AMELX BGLAP BMP2 CTSK DSPP
4 limbs/digits/tail MP:0005371 10.18 ACP5 BMP2 CTSK IBSP PTH RUNX2
5 craniofacial MP:0005382 10.18 AMBN AMELX BMP2 CTSK DSPP IBSP
6 skeleton MP:0005390 10.09 ACP5 AMBN AMELX BGLAP BMP2 CALCA
7 neoplasm MP:0002006 10.04 AMBN AMELX CALCA IL1B SPP1 TNFRSF11A
8 digestive/alimentary MP:0005381 10.01 AMELX BMP2 CTSK DSPP IBSP RUNX2
9 respiratory system MP:0005388 9.96 AMELX CALCA CTSK DSPP RUNX2 SH3BP2
10 hematopoietic system MP:0005397 9.83 ACP5 AMELX BGLAP BMP2 CTSK IBSP
11 integument MP:0010771 9.28 AMBN AMELX CALCA IL1B RUNX2 SERPINA3
Sources

Drugs & Therapeutics for Tooth Resorption

About this section

Drugs for Tooth Resorption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mometasone furoate Approved, Investigational, Vet_approved 83919-23-7 4240 441336

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Medico-economic Comparative Assessment of Conventional and CAD/CAM Dental Restorations; Impact on Hospital Dentistry Departments Unknown status NCT02494427
2 Three-dimensional Volumetric/ Linear Analysis and Axial Classification of Root Resorptions Using Cone Beam Computed Tomography: A Retrospective Study Completed NCT04617301
3 Comparison of Root Resorption, Microbial Colonization & Gingival Health Between Clear Aligners, Self-Ligating Brackets & Conventional Brackets- A Randomized Controlled Clinical Trial Completed NCT02745626
4 Detection of Orthodontically Induced Inflammatory Root Resorption From Gingival Crevicular Fluid by Proteomics Analysis: Split Mouth, Randomized Clinical Trial Completed NCT04291443
5 Placebo-Controlled, Randomized, Double Blind Trial of Effect of Photobiomodulation Therapies On The Root Resorption Associated With Orthodontic Forces: A Pilot Study Using Micro Computed Tomography Completed NCT04044989
6 Evaluation of the Efficacy of Injection Platelet-rich Fibrin(I-PRF) in Accelerate Alignment and Leveling in an Adult Sample Completed NCT04885842
7 Biological Anchorage With Selective Micro-osteroperforations (MOPs) in Canine Distalization Terminated NCT03741504

Search NIH Clinical Center for Tooth Resorption

Cochrane evidence based reviews: tooth resorption

Sources

Genetic Tests for Tooth Resorption

About this section
Sources

Anatomical Context for Tooth Resorption

About this section

Organs/tissues related to Tooth Resorption:

MalaCards : Bone, Eye
Sources

Publications for Tooth Resorption

About this section

Articles related to Tooth Resorption:

(show top 50) (show all 234)
# Title Authors PMID Year
1
Mononuclear odontoclast participation in tooth resorption: the distribution of nuclei in human odontoclasts. 53 62
9415452 1997
2
Equine Odontoclastic Tooth Resorption and Hypercementosis. 62
36198033 2022
3
Clinical, Diagnostic and Histological Findings Involving Cheek Teeth Hypercementosis in Nine Horses. 62
35996329 2022
4
Diphyodont tooth replacement of Brasilodon-A Late Triassic eucynodont that challenges the time of origin of mammals. 62
36065514 2022
5
Dental Pain in Cats: A Prospective 6-Month Study. 62
35603830 2022
6
25-Hydroxycholesterol induces odontoclastic differentiation through RANK-RANKL upregulation and NF-κB activation in odontoblast-like MDPC-23 cells: An in vitro study. 62
36462163 2022
7
Expression of Toll-like receptor and cytokine mRNAs in feline odontoclastic resorptive lesion (FORL) and feline oral health. 62
36113248 2022
8
[Pathogenesis and classification of tooth resorption]. 62
36379899 2022
9
Application of Two-Dimensional Entropy Measures to Detect the Radiographic Signs of Tooth Resorption and Hypercementosis in an Equine Model. 62
36428482 2022
10
Rapidly progressing generalised tooth resorption associated with primary immunodeficiency due to XIAP/BIRC4 mutation. 62
36254405 2022
11
Primary failure of eruption and tooth resorption 62
36217581 2022
12
Tooth resorption-Part 2: A clinical classification. 62
35605161 2022
13
Tooth Resorption - Part 1: The evolvement, rationales and controversies of tooth resorption. 62
35559593 2022
14
Equine Incisor Lesions: Histologic Confirmation of Radiographic, Macroscopic, and Micro-Computed Tomographic Findings. 62
35878366 2022
15
The Medical, Clinical, and Radiographic Aspects of Multiple Idiopathic Tooth Resorption: A Systematic Review. 62
35887679 2022
16
[Effects of human periodontal ligament fibroblast-derived exosomes on reducing rat root resorption after delayed tooth replantation]. 62
36204948 2022
17
Equine odontoclastic tooth resorption and hypercementosis: Investigating individual incisor disease patterns using radiological classification. 62
35575133 2022
18
Eyes wide open to avoid misleading diagnosis and treatment planning. 62
35369788 2022
19
Multivariate versus univariate spectrum analysis of dentine sialophosphoprotein (DSPP) for root resorption prediction: a clinical trial. 62
35488332 2022
20
A clinical approach strategy for the diagnosis, treatment and evaluation of external cervical resorption. 62
35034370 2022
21
Selection of Filtering and Image Texture Analysis in the Radiographic Images Processing of Horses' Incisor Teeth Affected by the EOTRH Syndrome. 62
35458905 2022
22
Analysis and Assessment of Pulp Vitality of 102 Intrinsically Stained Teeth in Dogs. 62
34825611 2022
23
Early incisor lesions and Equine Odontoclastic Tooth Resorption and Hypercementosis: Reliability of radiographic findings. 62
35302672 2022
24
Comparison between periapical radiography and cone beam computed tomography for the diagnosis of anterior maxillary trauma in children and adolescents. 62
34275178 2022
25
Application of Hyperbaric Oxygen Therapy (HBOT) as a Healing Aid after Extraction of Incisors in the Equine Odontoclastic Tooth Resorption and Hypercementosis Syndrome. 62
35051114 2022
26
Chemerin/ChemR23 regulates cementoblast function and tooth resorption in mice via inflammatory factors. 62
33289084 2021
27
[Extraction treatment on orthodontic patients with Stage â…£/Grade C periodontitis: a preliminary study]. 62
34619893 2021
28
Tooth Resorption Following an Alveolar Bone Graft in a Patient With Complete Unilateral Cleft Lip and Palate. 62
33167709 2021
29
Management of Root Perforation due to Internal Resorption: A 1-year Follow-up Study. 62
34824521 2021
30
Blood Parameters and Feline Tooth Resorption: A Retrospective Case Control Study from a Spanish University Hospital. 62
34359253 2021
31
EOTRH Syndrome in Polish Half-Bred Horses - Two Clinical Cases. 62
33993931 2021
32
Microbiome analysis of feline odontoclastic resorptive lesion (FORL) and feline oral health. 62
33856291 2021
33
Effect of root surface treatment with denusomab after delayed tooth replantation. 62
32728940 2021
34
Increased Presence of Complement Factors and Mast Cells in Alveolar Bone and Tooth Resorption. 62
33803323 2021
35
Immunocytochemical characterization of primary teeth pulp stem cells from three stages of resorption in serum-free medium. 62
32955751 2021
36
[Cinematic Rendering in Cone Beam Computed Tomography: Advanced 3D Reconstructions of Dental and Maxillofacial Pathologies]. 62
33559983 2021
37
DENTAL DISEASES AND OTHER ORAL PATHOLOGIES OF CAPTIVE JAGUARS (PANTHERA ONCA) FROM BELIZE, CENTRAL AMERICA. 62
33480566 2021
38
The two extremes of physiological tooth resorption in primary tooth with or without the permanent successor tooth. 62
34932715 2021
39
A Possible Relationship between Peri-Implantitis, Titanium Hypersensitivity, and External Tooth Resorption: Metal-Free Alternative to Titanium Implants. 62
33552604 2021
40
The Macroscopic and Radiographic Skull and Dental Pathology of the Tasmanian Devil (Sarcophilus harrisii). 62
34179178 2021
41
Update on Equine Odontoclastic Tooth Resorption and Hypercementosis. 62
33067098 2020
42
Dental Pathology of the Domestic Pig (Sus Scrofa Domesticus). 62
33601925 2020
43
Transcriptomic profiling of feline teeth highlights the role of matrix metalloproteinase 9 (MMP9) in tooth resorption. 62
33144645 2020
44
Teeth resorption at cement - enamel junction (CEJ) - Microscopy analysis. 62
32590194 2020
45
Alternative Methods of Repositioning Impacted Maxillary Canines in the Dental Arch-En Bloc Autotransplantation of a Tooth. 62
32307141 2020
46
Radiological and Histopathological Features of Internal Tooth Resorption. 62
32606158 2020
47
Prevalence, Radiographic, and Demographic Features of Buccal Bone Expansion in Cats: A Cross-Sectional Study at a Referral Institution. 62
32875972 2020
48
Oral and Dental Examination Findings in European Polecats (Mustela putorius). 62
32359635 2020
49
Tooth Resorption in Spanish Domestic Cats: Preliminary Data. 62
32115079 2020
50
Clinical and histopathological characterization of root resorption in replanted teeth: Two case reports. 62
32011510 2020
Sources

Variations for Tooth Resorption

About this section
Sources

Expression for Tooth Resorption

About this section
Search GEO for disease gene expression data for Tooth Resorption.
Sources

Pathways for Tooth Resorption

About this section

Pathways related to Tooth Resorption according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Extracellular matrix organization 66
Show member pathways
 12.44 SPP1 LAMC3 IBSP DSPP CTSK BMP2
2
Vitamin D receptor pathway 74
12.06 TNFSF11 SPP1 PTH BGLAP
3
Mesenchymal Stem Cells and Lineage-specific Markers 65
11.71 SPP1 SP7 RUNX2 PTH BMP2 BGLAP
4
Overlap between signal transduction pathways contributing to LMNA laminopathies 74
Show member pathways
 11.64 BMP2 CTSK RUNX2 SPP1
5
Lung fibrosis 74
11.5 SPP1 IL1B CALCA
6
RUNX2 regulates bone development 66
Show member pathways
 11.47 SP7 RUNX2 BGLAP
7
Clock-controlled autophagy in bone metabolism 74
11.46 TNFSF11 TNFRSF11A SP7 RUNX2 PTH CTSK
8
FGF signaling pathway 61
11.39 SPP1 RUNX2 BGLAP
9
Interleukin-11 signaling pathway 74
11.28 RUNX2 IBSP BGLAP
10
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 22
11.22 TNFSF11 SPP1 RUNX2 PTH IBSP BGLAP
11
Type I collagen synthesis in the context of osteogenesis imperfecta 74
11.13 TNFSF11 TNFRSF11A SP7
12
OSX and miRNAs in tooth development 74
11.1 SP7 RUNX2 DSPP
13
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
10.88 TNFSF11 TNFRSF11A SPP1 RUNX2 PTH IL1B
14
G-protein signaling_Rap2B regulation pathway 22
10.85 TNFSF11 SPP1 LAMC3 IL1B BMP2
15
Bone morphogenic protein signaling and regulation 74
10.64 RUNX2 BMP2
16
Autosomal recessive osteopetrosis pathways 74
10.58 TNFSF11 TNFRSF11A
Sources

GO Terms for Tooth Resorption

About this section

Cellular components related to Tooth Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.96 TNFSF11 SPP1 SERPINA3 PTH IL1B IBSP
2 extracellular region GO:0005576 9.77 AMBN AMELX BGLAP BMP2 CALCA CTSK

Biological processes related to Tooth Resorption according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 10.2 TNFRSF11A PTH IL1B CALCA BMP2
2 positive regulation of DNA-binding transcription factor activity GO:0051091 10.17 BMP2 IL1B TNFRSF11A TNFSF11
3 skeletal system development GO:0001501 10.15 RUNX2 PTH BMP2 BGLAP
4 response to ethanol GO:0045471 10.14 BGLAP CTSK PTH TNFRSF11A
5 chondrocyte differentiation GO:0002062 10.09 RUNX2 BMP2 AMELX
6 monocyte chemotaxis GO:0002548 10.08 CALCA TNFRSF11A TNFSF11
7 response to insulin GO:0032868 10.08 BGLAP CTSK SP7 TNFRSF11A
8 osteoclast differentiation GO:0030316 10.07 TNFSF11 TNFRSF11A BMP2
9 response to organic cyclic compound GO:0014070 10.07 TNFRSF11A SP7 CTSK BGLAP
10 embryo implantation GO:0007566 10.06 SPP1 IL1B CALCA
11 odontogenesis of dentin-containing tooth GO:0042475 10.01 AMBN AMELX BMP2 RUNX2
12 osteoblast differentiation GO:0001649 10 SPP1 SP7 RUNX2 IBSP BMP2 BGLAP
13 bone mineralization GO:0030282 9.97 PTH IBSP BMP2 BGLAP
14 positive regulation of bone resorption GO:0045780 9.93 TNFSF11 TNFRSF11A SPP1
15 bone resorption GO:0045453 9.92 TNFSF11 PTH CTSK ACP5
16 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.91 RUNX2 BMP2
17 response to vitamin D GO:0033280 9.91 SPP1 PTH BGLAP
18 TNFSF11-mediated signaling pathway GO:0071847 9.88 TNFSF11 TNFRSF11A
19 response to macrophage colony-stimulating factor GO:0036005 9.86 SPP1 BGLAP
20 cellular response to zinc ion starvation GO:0034224 9.86 BGLAP CTSK SP7 TNFRSF11A
21 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.81 TNFSF11 TNFRSF11A
22 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.8 TNFSF11 TNFRSF11A
23 ossification GO:0001503 9.73 BGLAP BMP2 CALCA IBSP RUNX2 SPP1
24 biomineral tissue development GO:0031214 9.4 SPP1 IBSP DSPP CEMP1 BGLAP AMELX

Molecular functions related to Tooth Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of tooth enamel GO:0030345 9.26 AMELX AMBN
2 hydroxyapatite binding GO:0046848 9.1 CEMP1 BGLAP AMELX
Sources

Sources for Tooth Resorption

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....