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MCID: TTH008
MIFTS: 38

Tooth Resorption

Categories: Oral diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Tooth Resorption

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MalaCards integrated aliases for Tooth Resorption:

Name: Tooth Resorption 12 54 44 15 70

Classifications:

MalaCards categories:
Anatomical: Oral diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:13240
ICD9CM 34 521.4
MeSH 44 D014091
SNOMED-CT 67 70931000
ICD10 32 K03.3
UMLS 70 C0040451
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Summaries for Tooth Resorption

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MalaCards based summary : Tooth Resorption is related to hypercementosis and teeth, supernumerary, and has symptoms including toothache An important gene associated with Tooth Resorption is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are Degradation of the extracellular matrix and RANK Signaling in Osteoclasts. The drug mometasone furoate has been mentioned in the context of this disorder. Affiliated tissues include bone, eye and colon, and related phenotypes are craniofacial and hematopoietic system

Wikipedia : 73 Tooth resorption, or root resorption, is the progressive loss of dentine and cementum by the action of... more...

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Related Diseases for Tooth Resorption

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Diseases related to Tooth Resorption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 hypercementosis 30.8 LAMC3 DSPP AMELX AMBN
2 teeth, supernumerary 30.3 RUNX2 DSPP
3 periodontitis, chronic 29.9 TNFSF11 IL1B
4 aneurysmal bone cysts 29.7 TNFSF11 TNFRSF11A CALCA
5 ankylosis 29.6 TNFSF11 RUNX2 IBSP BMP2 BGLAP
6 periodontitis 29.3 TNFSF11 SERPINA3 RUNX2 IL1B CTSK BGLAP
7 root resorption 29.0 TNFSF11 TNFRSF11A SPP1 RUNX2 IL1B DSPP
8 gingival recession 28.9 TNFSF11 IL1B DSPP CEMP1 BMP2 AMBN
9 dental pulp necrosis 28.9 TNFSF11 IL1B IBSP DSPP BMP2 BGLAP
10 bone resorption disease 26.9 TNFSF11 TNFRSF11A SPP1 SERPINA3 RUNX2 PTH
11 dentine erosion 10.3 AMELX AMBN
12 dental pulp calcification 10.3 DSPP AMELX
13 femoral cancer 10.3 TNFSF11 ACP5
14 amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2 10.3 AMELX AMBN
15 enamel caries 10.3 AMELX AMBN
16 osteopetrosis, autosomal recessive 2 10.3 TNFSF11 CTSK ACP5
17 pulp degeneration 10.3 DSPP AMELX AMBN
18 diamond-blackfan anemia 6 10.3 IBSP BMP2
19 spondylolysis 10.3 CTSK BMP2
20 osteopetrosis, autosomal recessive 8 10.3 TNFSF11 CTSK ACP5
21 tooth erosion 10.3 DSPP AMELX AMBN
22 pycnodysostosis 10.2 TNFSF11 CTSK ACP5
23 trichodentoosseous syndrome 10.2 DSPP AMELX AMBN
24 multicentric reticulohistiocytosis 10.2 TNFSF11 SERPINA3
25 kummell's disease 10.2 TNFSF11 CALCA
26 hermansky-pudlak syndrome 6 10.2 AMELX AMBN
27 osteopetrosis, autosomal dominant 2 10.2 TNFSF11 BGLAP ACP5
28 hair whorl 10.2
29 amelogenesis imperfecta, type ib 10.2 AMELX AMBN
30 root caries 10.2 DSPP AMELX
31 dentin dysplasia, type ii 10.2 SPP1 IBSP DSPP
32 wiedemann-rautenstrauch syndrome 10.2 SPP1 BGLAP
33 syndromic craniosynostosis 10.2 SPP1 RUNX2
34 synovial chondromatosis 10.2 RUNX2 BMP2
35 pigmented villonodular synovitis 10.2 TNFSF11 SERPINA3 ACP5
36 fibrosarcomatous osteosarcoma 10.2 SERPINA3 BGLAP
37 polyarticular onset juvenile idiopathic arthritis 10.2 TNFSF11 TNFRSF11A
38 hemophilic arthropathy 10.2 TNFSF11 TNFRSF11A
39 dentinogenesis imperfecta 10.2 SPP1 IBSP DSPP
40 epulis 10.2 SERPINA3 AMELX
41 dental abscess 10.1 PTH DSPP
42 nodular tenosynovitis 10.1 SERPINA3 ACP5
43 disseminated chorioretinitis 10.1 TNFSF11 TNFRSF11A
44 calcific tendinitis 10.1 SPP1 CTSK BMP2
45 bone osteosarcoma 10.1 TNFSF11 RUNX2 BGLAP
46 ossification of the posterior longitudinal ligament of spine 10.1 RUNX2 BMP2 BGLAP
47 autosomal recessive hypophosphatemic rickets 10.1 PTH IBSP DSPP
48 osteofibrous dysplasia 10.1 SPP1 BMP2 BGLAP
49 saethre-chotzen syndrome 10.1 RUNX2 IBSP BGLAP
50 dental fluorosis 10.1 DSPP BGLAP AMELX AMBN

Graphical network of the top 20 diseases related to Tooth Resorption:



Diseases related to Tooth Resorption
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Symptoms & Phenotypes for Tooth Resorption

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UMLS symptoms related to Tooth Resorption:


toothache

MGI Mouse Phenotypes related to Tooth Resorption:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 10.02 AMBN BMP2 CTSK IBSP IL1B PTH
2 hematopoietic system MP:0005397 10 BGLAP BMP2 CTSK IBSP IL1B LAMC3
3 immune system MP:0005387 9.9 BGLAP BMP2 CTSK IBSP IL1B LAMC3
4 limbs/digits/tail MP:0005371 9.5 BMP2 CTSK IBSP PTH RUNX2 TNFRSF11A
5 skeleton MP:0005390 9.36 AMBN BGLAP BMP2 CTSK IBSP IL1B
Sources

Drugs & Therapeutics for Tooth Resorption

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Drugs for Tooth Resorption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
mometasone furoate Approved, Investigational, Vet_approved 83919-23-7

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Medico-economic Comparative Assessment of Conventional and CAD/CAM Dental Restorations; Impact on Hospital Dentistry Departments Unknown status NCT02494427
2 Detection of Orthodontically Induced Inflammatory Root Resorption From Gingival Crevicular Fluid by Proteomics Analysis: Split Mouth, Randomized Clinical Trial Completed NCT04291443
3 Comparison of Root Resorption, Microbial Colonization & Gingival Health Between Clear Aligners, Self-Ligating Brackets & Conventional Brackets- A Randomized Controlled Clinical Trial Completed NCT02745626
4 Three-dimensional Volumetric/ Linear Analysis and Axial Classification of Root Resorptions Using Cone Beam Computed Tomography: A Retrospective Study Completed NCT04617301
5 Placebo-Controlled, Randomized, Double Blind Trial of Effect of Photobiomodulation Therapies On The Root Resorption Associated With Orthodontic Forces: A Pilot Study Using Micro Computed Tomography Completed NCT04044989
6 Biological Anchorage With Selective Micro-osteroperforations (MOPs) in Canine Distalization Terminated NCT03741504

Search NIH Clinical Center for Tooth Resorption

Cochrane evidence based reviews: tooth resorption

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Genetic Tests for Tooth Resorption

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Anatomical Context for Tooth Resorption

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MalaCards organs/tissues related to Tooth Resorption:

40
Bone, Eye, Colon, Kidney, Thyroid, Breast
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Publications for Tooth Resorption

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Articles related to Tooth Resorption:

(show top 50) (show all 203)
# Title Authors PMID Year
1
Mononuclear odontoclast participation in tooth resorption: the distribution of nuclei in human odontoclasts. 54 61
9415452 1997
2
Effect of root surface treatment with denusomab after delayed tooth replantation. 61
32728940 2021
3
Increased Presence of Complement Factors and Mast Cells in Alveolar Bone and Tooth Resorption. 61
33803323 2021
4
Immunocytochemical characterization of primary teeth pulp stem cells from three stages of resorption in serum-free medium. 61
32955751 2021
5
[Cinematic Rendering in Cone Beam Computed Tomography: Advanced 3D Reconstructions of Dental and Maxillofacial Pathologies]. 61
33559983 2021
6
A Possible Relationship between Peri-Implantitis, Titanium Hypersensitivity, and External Tooth Resorption: Metal-Free Alternative to Titanium Implants. 61
33552604 2021
7
DENTAL DISEASES AND OTHER ORAL PATHOLOGIES OF CAPTIVE JAGUARS (PANTHERA ONCA) FROM BELIZE, CENTRAL AMERICA. 61
33480566 2021
8
Chemerin/ChemR23 regulates cementoblast function and tooth resorption in mice via inflammatory factors. 61
33289084 2020
9
Update on Equine Odontoclastic Tooth Resorption and Hypercementosis. 61
33067098 2020
10
Dental Pathology of the Domestic Pig (Sus Scrofa Domesticus). 61
33601925 2020
11
Transcriptomic profiling of feline teeth highlights the role of matrix metalloproteinase 9 (MMP9) in tooth resorption. 61
33144645 2020
12
Tooth Resorption Following an Alveolar Bone Graft in a Patient With Complete Unilateral Cleft Lip and Palate. 61
33167709 2020
13
Teeth resorption at cement - enamel junction (CEJ) - Microscopy analysis. 61
32590194 2020
14
Alternative Methods of Repositioning Impacted Maxillary Canines in the Dental Arch-En Bloc Autotransplantation of a Tooth. 61
32307141 2020
15
Radiological and Histopathological Features of Internal Tooth Resorption. 61
32606158 2020
16
Prevalence, Radiographic, and Demographic Features of Buccal Bone Expansion in Cats: A Cross-Sectional Study at a Referral Institution. 61
32875972 2020
17
Oral and Dental Examination Findings in European Polecats (Mustela putorius). 61
32359635 2020
18
Tooth Resorption in Spanish Domestic Cats: Preliminary Data. 61
32115079 2020
19
Clinical and histopathological characterization of root resorption in replanted teeth: Two case reports. 61
32011510 2020
20
History, clinical findings and outcome of horses with radiographical signs of equine odontoclastic tooth resorption and hypercementosis. 61
31601733 2019
21
Prenatal developmental sequence of the skull of minke whales and its implications for the evolution of mysticetes and the teeth-to-baleen transition. 61
31216066 2019
22
Piezocision-assisted orthodontic treatment using CAD/CAM customized orthodontic appliances: a randomized controlled trial in adults. 61
30649257 2019
23
Comparative evaluation of the efficacy of three methods of delivering calcium hydroxide into the root canal. 61
31274253 2019
24
Dental trauma on primary teeth at different root resorption stages-A dynamic finite element impact analysis of the effect on the permanent tooth germ. 61
30561893 2019
25
Non-Invasive management of invasive cervical resorption associated with periodontal pocket: A case report. 61
31024958 2019
26
Odontogenic myxoma: An updated analysis of 1,692 cases reported in the literature. 61
29683236 2019
27
[Dental root resorption etiology, diagnosis and treatment]. 61
31322606 2019
28
Types of root resorptions related to orthodontic treatment. 61
31619660 2019
29
A multidisciplinary study of pain in cats undergoing dental extractions: A prospective, blinded, clinical trial. 61
30822336 2019
30
Periodontal status of anterior teeth following clinical crown lengthening by minimally traumatic controlled surgical extrusion. 61
30207629 2018
31
Evaluation of mandibular odontogenic keratocyst and ameloblastoma by panoramic radiograph and computed tomography. 61
29791200 2018
32
Outcome of Autotransplantation of Mature Third Molars Using 3-dimensional-printed Guiding Templates and Donor Tooth Replicas. 61
30154002 2018
33
Dental Pathology of the Iberian Lynx ( Lynx pardinus), Part II: Periodontal Disease, Tooth Resorption, and Oral Neoplasia. 61
30168375 2018
34
Nonsurgical Management and 2-year Follow-up by means of Cone Beam Computed Tomography of an Invasive Cervical Resorption in a Molar. 61
30287720 2018
35
Oral and Dental Examination Findings in Beech Martens (Martes foina). 61
30213368 2018
36
Oral and dental anomalies in purebred, brachycephalic Persian and Exotic cats. 61
29911947 2018
37
Radiological prevalence of equine odontoclastic tooth resorption and hypercementosis. 61
29067719 2018
38
Conservative Approach for Treatment of Maxillary Lateral Incisor Agenesis With the Deciduous Tooth Retained: 18-Month Follow-Up. 61
29337645 2018
39
Efficiency of different storage media for avulsed teeth in animal models: a systematic review. 61
28853235 2018
40
Size distribution and clinicoradiological signs of aggressiveness in odontogenic myxoma-three-dimensional analysis and systematic review. 61
29082773 2018
41
Evaluation of the diagnostic yield of dental radiography and cone-beam computed tomography for the identification of dental disorders in small to medium-sized brachycephalic dogs. 61
29287156 2018
42
External tooth resorption associated with a peripheral odontogenic fibroma: review and case report. 61
28665047 2017
43
A case series of intraosseous hemangioma of the jaws: Various presentations of a rare entity. 61
29302291 2017
44
External Cervical Resorption: A New Oral Manifestation of Systemic Sclerosis. 61
28606671 2017
45
Hematologic, Biochemical, and Endocrine Parameters in Horses With Tooth Resorption and Hypercementosis. 61
28814178 2017
46
Radiographic evaluation in clinical practice of the types and stage of incisor tooth resorption and hypercementosis in horses. 61
27862232 2017
47
Management of invasive cervical resorption using a surgical approach followed by an internal approach after 2 months due to pulpal involvement. 61
29279629 2017
48
Dental and Temporomandibular Joint Pathology of the California Mountain Lion (Puma concolor couguar). 61
28024874 2017
49
Paleobiology: A Tooth for a Tooth. 61
28171758 2017
50
Some historical musings on tooth/root resorption. 61
29354305 2017
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Variations for Tooth Resorption

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Expression for Tooth Resorption

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Search GEO for disease gene expression data for Tooth Resorption.
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Pathways for Tooth Resorption

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Pathways related to Tooth Resorption according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 65
Show member pathways
 12.53 SPP1 LAMC3 IBSP DSPP CTSK BMP2
2
RANK Signaling in Osteoclasts 63
Show member pathways
 12.49 TNFSF11 TNFRSF11A IL1B CTSK ACP5
3
ECM-receptor interaction 36
Show member pathways
 11.95 SPP1 LAMC3 IBSP DSPP
4
Parathyroid hormone synthesis, secretion and action 36
11.76 TNFSF11 RUNX2 PTH BGLAP
5
NF-kappa B signaling pathway 36
11.75 TNFSF11 TNFRSF11A IL1B
6
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.74 SPP1 RUNX2 PTH BMP2 BGLAP
7
Rheumatoid arthritis 36
11.7 TNFSF11 TNFRSF11A PTH IL1B CTSK ACP5
8
Endochondral Ossification 1
11.53 SPP1 RUNX2 PTH
9
Lung fibrosis 1
11.5 SPP1 IL1B CALCA
10
FGF signaling pathway 1
11.34 SPP1 RUNX2 BGLAP
11
Interleukin-11 Signaling Pathway 1
11.3 RUNX2 IBSP BGLAP
12
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 23
11.02 TNFSF11 SPP1 RUNX2 PTH IBSP BGLAP
13
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
10.88 TNFSF11 TNFRSF11A SPP1 RUNX2 PTH IL1B
14
G-protein signaling_Rap2B regulation pathway 23
10.85 TNFSF11 SPP1 LAMC3 IL1B BMP2
15
Osteoblast Signaling 1
10.77 TNFSF11 PTH IBSP BGLAP
16
Osteoclast Signaling 1
10.76 TNFSF11 TNFRSF11A SPP1 CTSK ACP5
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GO Terms for Tooth Resorption

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Cellular components related to Tooth Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 TNFSF11 SPP1 SERPINA3 PTH IL1B IBSP
2 extracellular region GO:0005576 9.47 TNFSF11 SPP1 SERPINA3 PTH LAMC3 IL1B
3 endoplasmic reticulum lumen GO:0005788 9.46 SPP1 BGLAP AMELX AMBN

Biological processes related to Tooth Resorption according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 10.01 SPP1 LAMC3 IBSP BGLAP AMELX AMBN
2 inflammatory response GO:0006954 9.97 SPP1 SERPINA3 IL1B CALCA BMP2
3 extracellular matrix organization GO:0030198 9.91 SPP1 LAMC3 IBSP DSPP
4 cellular protein metabolic process GO:0044267 9.91 SPP1 CALCA AMELX AMBN
5 cell-cell signaling GO:0007267 9.85 TNFRSF11A PTH IL1B CALCA BMP2
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.8 TNFSF11 TNFRSF11A IL1B
7 cellular response to growth factor stimulus GO:0071363 9.77 IBSP BMP2 BGLAP
8 bone mineralization GO:0030282 9.74 IBSP BMP2 BGLAP
9 monocyte chemotaxis GO:0002548 9.73 TNFSF11 TNFRSF11A CALCA
10 chondrocyte differentiation GO:0002062 9.72 RUNX2 BMP2 AMELX
11 skeletal system development GO:0001501 9.72 RUNX2 PTH DSPP BMP2 BGLAP
12 embryo implantation GO:0007566 9.69 SPP1 IL1B CALCA
13 odontogenesis of dentin-containing tooth GO:0042475 9.67 RUNX2 BMP2 AMELX AMBN
14 osteoblast development GO:0002076 9.64 RUNX2 BGLAP
15 mammary gland alveolus development GO:0060749 9.63 TNFSF11 TNFRSF11A
16 osteoblast differentiation GO:0001649 9.63 SPP1 RUNX2 IBSP BMP2 BGLAP AMELX
17 positive regulation of ossification GO:0045778 9.62 PTH BMP2
18 regulation of osteoclast differentiation GO:0045670 9.62 TNFSF11 BGLAP
19 positive regulation of bone resorption GO:0045780 9.61 TNFSF11 TNFRSF11A SPP1
20 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.6 RUNX2 BMP2
21 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.58 RUNX2 BMP2
22 response to vitamin D GO:0033280 9.58 SPP1 PTH BGLAP
23 bone resorption GO:0045453 9.56 TNFSF11 PTH CTSK ACP5
24 TNFSF11-mediated signaling pathway GO:0071847 9.52 TNFSF11 TNFRSF11A
25 biomineral tissue development GO:0031214 9.5 SPP1 IBSP DSPP CEMP1 BGLAP AMELX
26 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.49 TNFSF11 TNFRSF11A
27 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.48 TNFSF11 TNFRSF11A
28 ossification GO:0001503 9.28 TNFSF11 TNFRSF11A SPP1 RUNX2 IBSP DSPP

Molecular functions related to Tooth Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 TNFSF11 SPP1 IL1B BMP2
2 structural constituent of tooth enamel GO:0030345 8.96 AMELX AMBN
3 hydroxyapatite binding GO:0046848 8.8 CEMP1 BGLAP AMELX
Sources

Sources for Tooth Resorption

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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