Aliases & Classifications for Tooth Resorption

MalaCards integrated aliases for Tooth Resorption:

Name: Tooth Resorption 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13240
ICD10 33 K03.3
ICD9CM 35 521.4
MeSH 44 D014091
SNOMED-CT 68 196316003 70931000
UMLS 73 C0040451

Summaries for Tooth Resorption

MalaCards based summary : Tooth Resorption is related to periodontitis and aneurysmal bone cysts, and has symptoms including toothache An important gene associated with Tooth Resorption is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are Degradation of the extracellular matrix and RANK Signaling in Osteoclasts. The drugs Methylene blue and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are craniofacial and hematopoietic system

Wikipedia : 76 Root resorption is the progressive loss of dentine and cementum by the action of osteoclasts. This is a... more...

Related Diseases for Tooth Resorption

Diseases related to Tooth Resorption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 periodontitis 30.1 CTSK TNFRSF11B TNFSF11
2 aneurysmal bone cysts 30.0 TNFRSF11A TNFSF11
3 periodontal disease 29.6 TNFRSF11A TNFRSF11B TNFSF11
4 hypercementosis 28.4 ACP5 CTSK DSPP PTH1R TNFRSF11A
5 villonodular synovitis 10.6 ACP5 TNFSF11
6 multicentric reticulohistiocytosis 10.5 TNFRSF11B TNFSF11
7 kummell's disease 10.5 TNFRSF11B TNFSF11
8 periodontitis, chronic 10.5 TNFRSF11B TNFSF11
9 chronic apical periodontitis 10.5 TNFRSF11B TNFSF11
10 pigmented villonodular synovitis 10.5 ACP5 TNFSF11
11 dentin dysplasia, type ii 10.4 DSPP IBSP
12 bone giant cell tumor 10.4 ACP5 CTSK
13 breast leiomyosarcoma 10.4 TNFRSF11A TNFSF11
14 secondary hyperparathyroidism of renal origin 10.3 ACP5 TNFRSF11B
15 bone inflammation disease 10.2 ACP5 TNFRSF11B TNFSF11
16 dental pulp necrosis 10.2 AMELX DSPP
17 dentin dysplasia 10.2 DSPP IBSP
18 dental abscess 10.2 ACP5 AMELX
19 dental fluorosis 10.2 AMELX DSPP
20 polyarticular onset juvenile idiopathic arthritis 10.0 TNFRSF11A TNFRSF11B TNFSF11
21 hemophilic arthropathy 10.0 TNFRSF11A TNFRSF11B TNFSF11
22 paget disease of bone 5, juvenile-onset 10.0 TNFRSF11A TNFRSF11B TNFSF11
23 familial expansile osteolysis 10.0 TNFRSF11A TNFRSF11B TNFSF11
24 osteopetrosis 9.9 CTSK TNFRSF11A TNFSF11
25 chondroblastoma 9.8 PTH1R TNFSF11
26 osteogenesis imperfecta, type vi 9.8 IBSP TNFSF11
27 ankylosis 9.8 BMP2 IBSP TNFRSF11B
28 cervicitis 9.8
29 herpes zoster 9.8
30 stomatitis 9.8
31 aneurysm 9.8
32 d-2-hydroxyglutaric aciduria 1 9.7 ACP5 PTH1R
33 glucocorticoid-induced osteoporosis 9.7 ACP5 BMP2 TNFRSF11B TNFSF11
34 osteonecrosis 9.7 ACP5 BMP2 TNFRSF11B TNFSF11
35 enchondromatosis, multiple, ollier type 9.7 ACP5 PTH1R
36 osteomyelitis 9.7 ACP5 BMP2 CTSK TNFSF11
37 teeth hard tissue disease 9.6 ACP5 AMELX DSPP TNFSF11
38 paget's disease of bone 9.6 ACP5 TNFRSF11A TNFRSF11B TNFSF11
39 aortic valve disease 1 9.6 BMP2 TNFRSF11B
40 endosteal hyperostosis, autosomal dominant 9.6 BMP2 CTSK TNFRSF11B TNFSF11
41 tooth ankylosis 9.5 BMP2 PTH1R TNFSF11
42 giant cell tumor 9.5 CTSK TNFRSF11A TNFRSF11B TNFSF11
43 skeletal dysplasias 9.5 CTSK PTH1R
44 brittle bone disorder 9.5 DSPP IBSP PTH1R
45 aortic valve disease 2 9.4 BMP2 IBSP TNFRSF11B TNFSF11
46 periapical periodontitis 9.3 ACP5 DSPP TNFRSF11A TNFRSF11B TNFSF11
47 root resorption 9.2 CTSK DSPP TNFRSF11A TNFRSF11B TNFSF11
48 multicentric carpotarsal osteolysis syndrome 9.2 ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11
49 ischemic bone disease 9.1 ACP5 BMP2 TNFRSF11A TNFRSF11B TNFSF11
50 rheumatoid arthritis 9.1 ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Tooth Resorption:



Diseases related to Tooth Resorption

Symptoms & Phenotypes for Tooth Resorption

UMLS symptoms related to Tooth Resorption:


toothache

MGI Mouse Phenotypes related to Tooth Resorption:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.91 BMP2 CTSK IBSP PTH1R TNFRSF11A TNFRSF11B
2 hematopoietic system MP:0005397 9.86 BMP2 CTSK IBSP LAMC3 PTH1R TNFRSF11A
3 immune system MP:0005387 9.76 IBSP LAMC3 PTH1R TNFRSF11A TNFRSF11B TNFSF11
4 digestive/alimentary MP:0005381 9.72 BMP2 CTSK IBSP PTH1R TNFRSF11A
5 limbs/digits/tail MP:0005371 9.5 TNFRSF11A TNFRSF11B TNFSF11 BMP2 CTSK IBSP
6 skeleton MP:0005390 9.23 BMP2 CTSK IBSP LAMC3 PTH1R TNFRSF11A

Drugs & Therapeutics for Tooth Resorption

Drugs for Tooth Resorption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylene blue Approved, Investigational Not Applicable 61-73-4
2 Anesthetics Not Applicable
3 Anesthetics, Local Not Applicable
4 Anti-Bacterial Agents Not Applicable
5 Pharmaceutical Solutions Not Applicable
6 Photosensitizing Agents Not Applicable
7 Anti-Infective Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Repair of Orthodontically-induced Tooth Root Resorption by Ultrasound Unknown status NCT00423956 Phase 1, Phase 2
2 Histological Change of The Dentinal-Pulp Complex and Root Resorption Completed NCT01642693 Phase 1, Phase 2
3 Labial Alveolar Bone Thickness and Apical Root Resorption Changes Associated With Self-ligating Versus Conventional Brackets Unknown status NCT02816489 Not Applicable
4 Volumetric Analysis of Root Resorption With Mini-Screw Implant Anchorage-assisted Retraction of Maxillary Incisors Unknown status NCT02221206 Not Applicable
5 Comparison of Oral Hygiene & Root Resorption During Orthodontic Treatment Completed NCT02745626 Not Applicable
6 An Evaluation of Root Length Measurements Using Intraoral Scan and Panoramic Radiographs Completed NCT02822040
7 Comparison of Conventional and CAD/CAM Dental Restorations Active, not recruiting NCT02494427 Not Applicable
8 Evaluation of Antimicrobial Photodynamic Therapy for the Treatment of Deep Carious Lesions in Children: an in Vivo Study Active, not recruiting NCT02908789 Not Applicable
9 Stainless Steel Crowns Versus Bulkfill Composite Resin for Restoring Primary Molars After Endodontic Treatment Active, not recruiting NCT03186950 Not Applicable

Search NIH Clinical Center for Tooth Resorption

Cochrane evidence based reviews: tooth resorption

Genetic Tests for Tooth Resorption

Anatomical Context for Tooth Resorption

MalaCards organs/tissues related to Tooth Resorption:

41
Bone

Publications for Tooth Resorption

Articles related to Tooth Resorption:

(show top 50) (show all 59)
# Title Authors Year
1
External tooth resorption associated with a peripheral odontogenic fibroma: review and case report. ( 28665047 )
2017
2
Radiological prevalence of equine odontoclastic tooth resorption and hypercementosis. ( 29067719 )
2017
3
Hematologic, Biochemical, and Endocrine Parameters in Horses With Tooth Resorption and Hypercementosis. ( 28814178 )
2017
4
COMPUTED TOMOGRAPHY OF TOOTH RESORPTION IN CATS. ( 27377036 )
2016
5
Radiographic evaluation in clinical practice of the types and stage of incisor tooth resorption and hypercementosis in horses. ( 27862232 )
2016
6
Tooth Resorption: The "Black Hole" of Dentistry. ( 26749878 )
2015
7
A novel multimodular methodology to investigate external cervical tooth resorption. ( 25819599 )
2015
8
Tooth resorption in cats: Pathophysiology and treatment options. ( 25527492 )
2015
9
Novel treatment of equine odontoclastic tooth resorption and hypercementosis of incisor teeth in a 22-year-old Arabian mare. ( 26246633 )
2015
10
Equine Odontoclastic Tooth Resorption and Hypercementosis: Histopathologic Features. ( 26077784 )
2015
11
Clinical treatment and prognosis of equine odontoclastic tooth resorption and hypercementosis. ( 25557855 )
2014
12
Tooth resorption in an Australian sea lion. ( 25185335 )
2014
13
Risk assessment of feline tooth resorption: a Portuguese clinical case control study. ( 24006716 )
2013
14
Tooth resorption part II - external resorption: Case series. ( 23716975 )
2013
15
Isolation of Treponema and Tannerella spp. from equine odontoclastic tooth resorption and hypercementosis related periodontal disease. ( 23742079 )
2013
16
Tooth resorption part I - pathogenesis and case series of internal resorption. ( 23349568 )
2013
17
Radiographic changes associated with tooth resorption type 2 in cats. ( 22792857 )
2012
18
Prevalence and types of tooth resorption in dogs with oral tumors. ( 22738058 )
2012
19
Osteoclast progenitors from cats with and without tooth resorption respond differently to 1,25-dihydroxyvitamin D and interleukin-6. ( 21497870 )
2012
20
Internal resorption: an unusual form of tooth resorption. ( 27365850 )
2011
21
Increased vitamin D-driven signalling and expression of the vitamin D receptor, MSX2, and RANKL in tooth resorption in cats. ( 20156263 )
2010
22
Presence and quantification of mast cells in the gingiva of cats with tooth resorption, periodontitis and chronic stomatitis. ( 20018273 )
2010
23
Equine odontoclastic tooth resorption and hypercementosis. ( 21140603 )
2010
24
Radiographic evaluation of the types of tooth resorption in dogs. ( 20594081 )
2010
25
Radiographic evaluation of the classification of the extent of tooth resorption in dogs. ( 20594082 )
2010
26
Tooth resorption in the Swedish Eurasion lynx (Lynx lynx). ( 21322429 )
2010
27
Tooth resorption and vitamin D3 status in cats fed premium dry diets. ( 21038831 )
2010
28
Alendronate binds to tooth root surfaces and inhibits progression of feline tooth resorption: a pilot proof-of-concept study. ( 19718970 )
2009
29
Significant association between tooth extrusion and tooth resorption in domestic cats. ( 18751658 )
2008
30
Equine odontoclastic tooth resorption and hypercementosis. ( 19010701 )
2008
31
Feline tooth resorption in a colony of 109 cats. ( 19025137 )
2008
32
Herpes zoster associated with tooth resorption and periapical lesions. ( 16054735 )
2007
33
Management of tooth resorption. ( 17546866 )
2007
34
Expression of MT1-MMP during deciduous tooth resorption in odontoclasts. ( 17072736 )
2006
35
A scanning electron microscopy study of idiopathic external tooth resorption in the cat. ( 16018753 )
2005
36
Update on the etiology of tooth resorption in domestic cats. ( 15979519 )
2005
37
Localization of cathepsin K in bovine odontoclasts during deciduous tooth resorption. ( 11870419 )
2002
38
Expression of matrix metalloproteinase-9 mRNA and protein during deciduous tooth resorption in bovine odontoclasts. ( 12398942 )
2002
39
Detection of simulated internal tooth resorption using conventional radiography and subtraction imaging. ( 11571543 )
2001
40
Hypothermic insult to the periodontium: a model for the study of aseptic tooth resorption. ( 11202857 )
2000
41
Tooth resorption. ( 10323155 )
1999
42
Mononuclear odontoclast participation in tooth resorption: the distribution of nuclei in human odontoclasts. ( 9415452 )
1997
43
Expression of adhesion molecules during tooth resorption in feline teeth: a model system for aggressive osteoclastic activity. ( 8952617 )
1996
44
Case study #9 . Tooth resorption. ( 1292063 )
1992
45
Aneurysmal bone cyst of the maxilla--an association with tooth resorption. ( 1401102 )
1992
46
A morphometric study of bone and tooth volumes in the pipid frog Xenopus laevis (Daudin), with comments on the importance of tooth resorption during normal tooth replacement. ( 2926364 )
1989
47
Tooth resorption in the two-stage transplantation technique: a case report. ( 3472606 )
1987
48
An ultrastructural study of tooth resorption in the kitten. ( 3461025 )
1986
49
External tooth resorption following periodontal ligament injection. ( 3463699 )
1986
50
Tooth resorption in the two-stage transplantation technique--a case report. ( 6575825 )
1983

Variations for Tooth Resorption

Expression for Tooth Resorption

Search GEO for disease gene expression data for Tooth Resorption.

Pathways for Tooth Resorption

GO Terms for Tooth Resorption

Cellular components related to Tooth Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 AMELX BMP2 CTSK DSPP IBSP LAMC3

Biological processes related to Tooth Resorption according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.97 AMELX BMP2 DSPP TNFRSF11A TNFRSF11B TNFSF11
2 regulation of signaling receptor activity GO:0010469 9.86 AMELX BMP2 TNFRSF11B TNFSF11
3 regulation of cell proliferation GO:0042127 9.77 AMELX TNFRSF11A TNFRSF11B
4 extracellular matrix organization GO:0030198 9.76 DSPP IBSP LAMC3 TNFRSF11B
5 response to lipopolysaccharide GO:0032496 9.74 ACP5 TNFRSF11A TNFRSF11B
6 tumor necrosis factor-mediated signaling pathway GO:0033209 9.7 TNFRSF11A TNFRSF11B TNFSF11
7 osteoblast differentiation GO:0001649 9.69 AMELX BMP2 IBSP
8 skeletal system development GO:0001501 9.67 BMP2 DSPP PTH1R TNFRSF11B
9 chondrocyte differentiation GO:0002062 9.61 AMELX BMP2 PTH1R
10 monocyte chemotaxis GO:0002548 9.6 TNFRSF11A TNFSF11
11 epithelial to mesenchymal transition GO:0001837 9.58 AMELX BMP2
12 osteoclast differentiation GO:0030316 9.58 TNFRSF11A TNFSF11
13 bone mineralization GO:0030282 9.58 BMP2 IBSP PTH1R
14 positive regulation of bone resorption GO:0045780 9.55 TNFRSF11A TNFSF11
15 mammary gland alveolus development GO:0060749 9.54 TNFRSF11A TNFSF11
16 biomineral tissue development GO:0031214 9.5 AMELX DSPP IBSP
17 TNFSF11-mediated signaling pathway GO:0071847 9.48 TNFRSF11A TNFSF11
18 ossification GO:0001503 9.35 BMP2 DSPP PTH1R TNFRSF11A TNFSF11
19 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.26 TNFRSF11A TNFSF11
20 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.16 TNFRSF11A TNFSF11
21 bone resorption GO:0045453 8.92 ACP5 CTSK PTH1R TNFSF11

Molecular functions related to Tooth Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 BMP2 TNFRSF11B TNFSF11
2 tumor necrosis factor-activated receptor activity GO:0005031 8.62 TNFRSF11A TNFRSF11B

Sources for Tooth Resorption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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