Aliases & Classifications for Tooth Size

MalaCards integrated aliases for Tooth Size:

Name: Tooth Size 57

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
x-linked
also a y chromosome locus


HPO:

31
tooth size:
Inheritance x-linked inheritance


External Ids:

OMIM® 57 314240
SNOMED-CT via HPO 68 263934009 422775003

Summaries for Tooth Size

MalaCards based summary : Tooth Size is related to cleft lip/palate and cleft lip with or without cleft palate. An important gene associated with Tooth Size is PAX9 (Paired Box 9), and among its related pathways/superpathways are Pathways in cancer and Mesodermal Commitment Pathway. The drug Daminozide has been mentioned in the context of this disorder. Affiliated tissues include bone, brain and pituitary, and related phenotypes are abnormality of the dentition and Decreased replication of vaccinia virus (VACV)

More information from OMIM: 314240

Related Diseases for Tooth Size

Diseases related to Tooth Size via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 cleft lip/palate 30.0 MSX1 BMP4
2 cleft lip with or without cleft palate 29.4 MSX1 BMP4
3 cleft lip 29.4 SHH PAX9 MSX1 BMP4
4 hemifacial microsomia 29.4 MSX1 FGF8
5 tooth agenesis 28.9 SHH PAX9 MSX1 FGF8 BMP4
6 cleft palate, isolated 28.7 SHH PAX9 MSX1 FGF8 BMP4
7 hair whorl 10.6
8 47,xyy 10.1
9 bladder exstrophy-epispadias-cloacal exstrophy complex 10.0 SHH BMP4
10 pituitary hypoplasia 10.0 SHH BMP4
11 midline interhemispheric variant of holoprosencephaly 10.0 SHH FGF8
12 septopreoptic holoprosencephaly 10.0 SHH FGF8
13 hyaline fibromatosis syndrome 10.0 SHH BMP4
14 holoprosencephaly 4 10.0 SHH FGF8
15 alobar holoprosencephaly 10.0 SHH FGF8
16 lobar holoprosencephaly 10.0 SHH FGF8
17 holoprosencephaly 1 10.0 SHH FGF8
18 holoprosencephaly 11 10.0 SHH FGF8
19 microform holoprosencephaly 10.0 SHH FGF8
20 holoprosencephaly 7 10.0 SHH FGF8
21 colobomatous microphthalmia 10.0 SHH BMP4
22 solitary median maxillary central incisor 10.0 SHH FGF8
23 semilobar holoprosencephaly 10.0 SHH FGF8
24 anus, imperforate 9.9 SHH FGF8
25 pallister-hall syndrome 9.9 SHH FGF8
26 sacral defect with anterior meningocele 9.9 SHH FGF8
27 teeth, supernumerary 9.9
28 gingival recession 9.9
29 agnathia-otocephaly complex 9.9 SHH FGF8
30 townes-brocks syndrome 9.9 SHH FGF8
31 ulnar-mammary syndrome 9.9 FGF8 BMP4
32 tooth agenesis, selective, 1 9.9 PAX9 MSX1
33 apert syndrome 9.9 SHH FGF8
34 witkop syndrome 9.9 PAX9 MSX1
35 anodontia 9.9 PAX9 MSX1
36 heart septal defect 9.9 FGF8 BMP4
37 ankyloglossia with or without tooth anomalies 9.9 PAX9 MSX1
38 septooptic dysplasia 9.9 SHH FGF8
39 chromosome 10q23 deletion syndrome 9.9 MSX1 BMP4
40 vesicoureteral reflux 1 9.9 FGF8 BMP4
41 congenital nervous system abnormality 9.9 SHH FGF8
42 chromosomal duplication syndrome 9.9 SHH FGF8
43 diaphragmatic hernia, congenital 9.8 SHH BMP4
44 branchiooculofacial syndrome 9.8 MSX1 BMP4
45 down syndrome 9.8
46 gonadal dysgenesis 9.8
47 turner syndrome 9.8
48 sleep disorder 9.8
49 chromosomal triplication 9.8
50 thalassemia 9.8

Graphical network of the top 20 diseases related to Tooth Size:



Diseases related to Tooth Size

Symptoms & Phenotypes for Tooth Size

Human phenotypes related to Tooth Size:

31
# Description HPO Frequency HPO Source Accession
1 abnormality of the dentition 31 HP:0000164

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Teeth:
tooth size

Clinical features from OMIM®:

314240 (Updated 05-Apr-2021)

GenomeRNAi Phenotypes related to Tooth Size according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased replication of vaccinia virus (VACV) GR00362-A 8.32 MSX1

MGI Mouse Phenotypes related to Tooth Size:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.88 BMP4 FGF8 MSX1 PAX9 SHH
2 digestive/alimentary MP:0005381 9.85 BMP4 FGF8 MSX1 PAX9 SHH
3 embryo MP:0005380 9.83 BMP4 FGF8 MSX1 PAX9 SHH
4 endocrine/exocrine gland MP:0005379 9.8 BMP4 FGF8 MSX1 PAX9 SHH
5 hearing/vestibular/ear MP:0005377 9.77 BMP4 FGF8 MSX1 PAX9 SHH
6 limbs/digits/tail MP:0005371 9.72 BMP4 FGF8 MSX1 PAX9 SHH
7 muscle MP:0005369 9.65 BMP4 FGF8 MSX1 PAX9 SHH
8 normal MP:0002873 9.55 BMP4 FGF8 MSX1 PAX9 SHH
9 respiratory system MP:0005388 9.35 BMP4 FGF8 MSX1 PAX9 SHH
10 skeleton MP:0005390 9.02 BMP4 FGF8 MSX1 PAX9 SHH

Drugs & Therapeutics for Tooth Size

Drugs for Tooth Size (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Daminozide 1596-84-5

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Validity and Reliability of Measurements Made on Intra-oral Images of the Dental Arches Compared to Those Made on Poured Plaster Models in the Assessment of Tooth-size-arch-length-discrepancy, Bolton's Analysis and Little's Index of Irregularity. Completed NCT03648515
2 Detection of Correlation Between Facial Measurements and Tooth Size and Pulp Volume Using Cone Beam Computed Tomography Recruiting NCT04346641

Search NIH Clinical Center for Tooth Size

Genetic Tests for Tooth Size

Anatomical Context for Tooth Size

MalaCards organs/tissues related to Tooth Size:

40
Bone, Brain, Pituitary

Publications for Tooth Size

Articles related to Tooth Size:

(show top 50) (show all 913)
# Title Authors PMID Year
1
47,XXY males: sex chromosomes and tooth size. 57 61
7446531 1980
2
Short root anomaly. 57
4505388 1972
3
Odontogenesis-related candidate genes involved in variations of permanent teeth size. 61
33651240 2021
4
Genetic variants in tooth agenesis-related genes might be also involved in tooth size variations. 61
32648061 2021
5
A universal power law for modelling the growth and form of teeth, claws, horns, thorns, beaks, and shells. 61
33781258 2021
6
Effects of implant diameter, implant-abutment connection type, and bone density on the biomechanical stability of implant components and bone: A finite element analysis study. 61
33685654 2021
7
Examining the frequency of crenulated premolars and their association with crenulated molars. 61
33585856 2021
8
Dental and dentoalveolar dimensions in individuals with osteogenesis imperfecta. 61
33587862 2021
9
FGF10 and FGF13 genetic variation and tooth-size discrepancies. 61
33492380 2021
10
Evaluation of tooth size in non-syndromic cleft lip and palate patients: A retrospective Italian study. 61
33719480 2021
11
Clinical Management of Hypodontia of Two Mandibular Incisors. 61
33614171 2021
12
Managing restorative space, color matching, and tooth replacement with a novel implant through interdisciplinary treatment: A case report of partial anodontia and malformed teeth in the esthetic zone. 61
32945584 2021
13
Trabecular bone in domestic dogs and wolves: Implications for understanding human self-domestication. 61
32975051 2021
14
Treatment in a patient with congenital loss of both mandibular lateral incisors and severely retroclined maxillary central incisors. 61
33008709 2020
15
Comparison of Chu's Proportion Gauge with a T-bar Tip and a Two-Tip Compass in the Determination of Anterior Dentition Tooth Size in a Group of Puerto Ricans. 61
33320456 2020
16
Delayed maturation and reduced crown width of the permanent first mandibular molar in all subgroups of cleft lip and palate. 61
32386121 2020
17
Dissipating tooth-mass discrepancy caused by a set of mandibular incisor anomalies. 61
32736850 2020
18
The intraspecific diversity of tooth morphology in the large-spotted catshark Scyliorhinus stellaris: insights into the ontogenetic cues driving sexual dimorphism. 61
32667054 2020
19
Data Set For Computation Of Maxillary Arch Perimeter With Ramanujan's Equation For Ellipse In Different Skeletal Malocclusions. 61
32775580 2020
20
Convergent Evolution of Cichlid Fish Pharyngeal Jaw Dentitions in Mollusk-Crushing Predators: Comparative X-Ray Computed Tomography of Tooth Sizes, Numbers, and Replacement. 61
32584994 2020
21
Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss. 61
32908163 2020
22
Human permanent tooth sizes are associated with genes encoding oestrogen receptors. 61
32985343 2020
23
Functional Expression of Sodium-Dependent Glucose Transporter in Amelogenesis. 61
32345094 2020
24
Management of an adult patient with missing one mandibular incisor, severe overjet, and midline discrepancy with asymmetric extraction, lingual appliance, and skeletal anchorage: A case report. 61
32672660 2020
25
Dentoskeletal and tooth-size differences between Syrian and Hungarian adolescents with Class II division 1 malocclusion: a retrospective study. 61
32493458 2020
26
Tooth Enamel and its Dynamic Protein Matrix. 61
32585904 2020
27
Dentofacial biometry as a discriminant factor in the identification of remote Amazon indigenous populations. 61
32354435 2020
28
3D evaluation of tooth crown size ın unilateral cleft lip and palate patients. 61
32367864 2020
29
Bolton's analysis using a photogrammetric method on occlusal photographs. 61
33474548 2020
30
Direct measurement of radial fluence distribution inside a femtosecond laser filament core. 61
32403579 2020
31
The Tooth Size Discrepancy among Orthodontic Patients and Normal Occlusion Individuals from Saudi Arabia: A Three-Dimensional Scan Analysis of Diagnostic Casts. 61
33110327 2020
32
Is there a relationship between dental crowding and the size of the maxillary or mandibular apical base? 61
31549856 2020
33
Assessing the accuracy of two posterior tooth-size discrepancy prediction methods based on virtual occlusal setups. 61
31613145 2020
34
Solutions for atypical problems in the incisors area: a transdisciplinary challenge. 61
32490929 2020
35
Dental anomalies in craniofacial microsomia: A systematic review. 61
31608577 2020
36
The Role of Discoidin Domain Receptor 2 in Tooth Development. 61
31869264 2020
37
Three-dimensional geometric morphometric analysis of tooth shape in hypodontia: II size variation. 61
31401789 2020
38
In-depth morphological evaluation of tooth anatomic lengths with root canal configurations using cone beam computed tomography in North American population. 61
32049131 2020
39
Craniofacial characteristics of Syrian adolescents with Class II division 1 malocclusion: a retrospective study. 61
32742806 2020
40
Balance Between Tooth Size and Tooth Number Is Controlled by Hyaluronan. 61
32982773 2020
41
Evaluation of the effect of tooth size on smile attractiveness fromthe perspective of art students, dental students, and laypeople in Sanandaj, Iran, 2017. 61
32467946 2020
42
Single-Cell RNA-Sequencing From Mouse Incisor Reveals Dental Epithelial Cell-Type Specific Genes. 61
32984333 2020
43
Models of individual linear dimensions necessary for the construction of the correct form of dental arches in young men with a wide face, depending on the features of odontometric and cephalometric indicators. 61
32723934 2020
44
Three-dimensional comparison of 2 digital models obtained from cone-beam computed tomographic scans of polyvinyl siloxane impressions and plaster models. 61
31915610 2019
45
The influence of labiolingual and mesiodistal anterior tooth dimensions on interarch relationships: A modified anterior Bolton analysis. 61
31784006 2019
46
[Applicability of the Moyers mixed dentition analysis for the Hungarian population]. 61
31814421 2019
47
Smad7 Regulates Dental Epithelial Proliferation during Tooth Development. 61
31499015 2019
48
The bears from Dmanisi and the first dispersal of early Homo out of Africa. 61
31780699 2019
49
Oro-dental characteristics in patients with hypermobile Ehlers-Danlos Syndrome compared to a healthy control group. 61
31206735 2019
50
Orthodontic treatment with removal of one mandibular incisor: Outcome data and the importance of extraction site preparation. 61
31582117 2019

Variations for Tooth Size

Expression for Tooth Size

Search GEO for disease gene expression data for Tooth Size.

Pathways for Tooth Size

GO Terms for Tooth Size

Biological processes related to Tooth Size according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.01 SHH PAX9 MSX1 BMP4
2 multicellular organism development GO:0007275 9.95 SHH PAX9 MSX1 FGF8 BMP4
3 negative regulation of apoptotic process GO:0043066 9.93 SHH MSX1 FGF8 BMP4
4 negative regulation of transcription, DNA-templated GO:0045892 9.92 PAX9 MSX1 BMP4
5 positive regulation of cell proliferation GO:0008284 9.92 SHH FGF8 BMP4
6 positive regulation of gene expression GO:0010628 9.91 SHH FGF8 BMP4
7 kidney development GO:0001822 9.81 SHH FGF8 BMP4
8 lung development GO:0030324 9.77 SHH FGF8 BMP4
9 heart development GO:0007507 9.76 SHH MSX1 FGF8 BMP4
10 anterior/posterior pattern specification GO:0009952 9.75 SHH MSX1
11 BMP signaling pathway GO:0030509 9.74 MSX1 BMP4
12 cartilage development GO:0051216 9.74 MSX1 BMP4
13 determination of left/right symmetry GO:0007368 9.74 SHH FGF8
14 cellular response to growth factor stimulus GO:0071363 9.74 PAX9 BMP4
15 forebrain development GO:0030900 9.74 SHH MSX1 BMP4
16 roof of mouth development GO:0060021 9.73 SHH MSX1
17 camera-type eye development GO:0043010 9.73 SHH BMP4
18 heart looping GO:0001947 9.73 SHH FGF8
19 anatomical structure development GO:0048856 9.73 SHH PAX9
20 bone development GO:0060348 9.73 FGF8 BMP4
21 heart morphogenesis GO:0003007 9.73 MSX1 FGF8
22 cell fate commitment GO:0045165 9.73 SHH FGF8 BMP4
23 outflow tract morphogenesis GO:0003151 9.72 FGF8 BMP4
24 positive regulation of cell division GO:0051781 9.72 SHH FGF8
25 positive chemotaxis GO:0050918 9.72 FGF8 BMP4
26 dorsal/ventral pattern formation GO:0009953 9.72 SHH FGF8
27 embryonic skeletal system development GO:0048706 9.72 SHH BMP4
28 positive regulation of BMP signaling pathway GO:0030513 9.71 MSX1 BMP4
29 midbrain development GO:0030901 9.71 SHH MSX1
30 embryonic forelimb morphogenesis GO:0035115 9.71 SHH MSX1
31 branching involved in blood vessel morphogenesis GO:0001569 9.71 SHH FGF8
32 odontogenesis of dentin-containing tooth GO:0042475 9.71 SHH MSX1 BMP4
33 face morphogenesis GO:0060325 9.7 PAX9 MSX1
34 pituitary gland development GO:0021983 9.7 MSX1 BMP4
35 neuron fate commitment GO:0048663 9.7 SHH BMP4
36 telencephalon development GO:0021537 9.7 FGF8 BMP4
37 embryonic digit morphogenesis GO:0042733 9.7 SHH MSX1 BMP4
38 endoderm development GO:0007492 9.69 PAX9 BMP4
39 branching morphogenesis of an epithelial tube GO:0048754 9.69 SHH BMP4
40 outflow tract septum morphogenesis GO:0003148 9.69 FGF8 BMP4
41 embryonic limb morphogenesis GO:0030326 9.69 SHH MSX1 BMP4
42 vasculature development GO:0001944 9.68 SHH BMP4
43 dopaminergic neuron differentiation GO:0071542 9.68 SHH FGF8
44 thyroid gland development GO:0030878 9.68 SHH FGF8
45 signal transduction involved in regulation of gene expression GO:0023019 9.68 MSX1 FGF8
46 epithelial tube branching involved in lung morphogenesis GO:0060441 9.67 SHH BMP4
47 anatomical structure formation involved in morphogenesis GO:0048646 9.67 SHH BMP4
48 male genitalia development GO:0030539 9.67 SHH FGF8
49 positive regulation of cell differentiation GO:0045597 9.67 SHH FGF8 BMP4
50 mesonephros development GO:0001823 9.66 FGF8 BMP4

Molecular functions related to Tooth Size according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 8.62 FGF8 BMP4

Sources for Tooth Size

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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