MCID: TXC004
MIFTS: 27

Toxic Diffuse Goiter

Categories: Endocrine diseases

Aliases & Classifications for Toxic Diffuse Goiter

MalaCards integrated aliases for Toxic Diffuse Goiter:

Name: Toxic Diffuse Goiter 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10719
ICD9CM 35 242.00

Summaries for Toxic Diffuse Goiter

MalaCards based summary : Toxic Diffuse Goiter is related to graves' disease and goiter. An important gene associated with Toxic Diffuse Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Amine-derived hormones. Affiliated tissues include thyroid, whole blood and t cells, and related phenotype is endocrine/exocrine gland.

Related Diseases for Toxic Diffuse Goiter

Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 graves' disease 33.1 TSHR TPO TG SERPINA7 DIO2
2 goiter 30.7 TSHR TRH TPO TG SERPINA7
3 plummer's disease 30.2 TPO TG
4 nodular goiter 30.1 TSHR TPO TG
5 hypothyroidism 29.5 TSHR TRH TPO TG SERPINA7 DIO2
6 subacute lymphocytic thyroiditis 10.2 TPO TG
7 familial thyroid dyshormonogenesis 10.2 TPO TG
8 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.2 TPO TG
9 hashimoto encephalopathy 10.2 TSHR TPO
10 benign struma ovarii 10.2 TSHR TG
11 struma ovarii 10.2 TSHR TG
12 athyreosis 10.2 TSHR TG
13 premature menopause 10.2 TPO TG
14 dyshormonogenic goiter 10.2 TG SERPINA7
15 pernicious anemia 10.2 TPO TG
16 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.1 TPO TG
17 euthyroid sick syndrome 10.1 SERPINA7 DIO2
18 neonatal hypothyroidism 10.1 TSHR TPO TG
19 thyroid crisis 10.1 TG SERPINA7
20 myxedema 10.1 TSHR TPO TG
21 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 TSHR TPO TG
22 multinodular goiter 10.1 TSHR TPO TG
23 follicular adenoma 10.1 TSHR TPO TG
24 papillary carcinoma 10.1 TSHR TPO TG
25 differentiated thyroid carcinoma 10.1 TSHR TPO TG
26 papillary thyroid microcarcinoma 10.1 TSHR TG
27 hashimoto thyroiditis 10.1 TSHR TPO TG
28 hypothyroidism, congenital, nongoitrous, 2 10.1 TSHR TG SERPINA7
29 exophthalmos 10.1 TSHR TG
30 postsurgical hypothyroidism 10.1 TSHR TRH TG
31 thyroid hormone resistance, generalized, autosomal dominant 10.1 TRH TG SERPINA7
32 thyroid cancer, nonmedullary, 2 10.0 TSHR TPO TG DIO2
33 thyroid cancer 10.0 TSHR TPO TG DIO2
34 endemic goiter 10.0 TSHR TPO TG SERPINA7
35 nontoxic goiter 10.0 TSHR TPO TG SERPINA7
36 subacute thyroiditis 10.0 TG SERPINA7 TSHR TPO
37 congenital hypothyroidism 10.0 TSHR TPO TG SERPINA7
38 celiac disease 1 10.0 TPO TNFRSF25 TG
39 hypothyroidism, congenital, nongoitrous, 4 10.0 TRH TPO TG SERPINA7
40 chromophobe adenoma 10.0 TRH SERPINA7
41 diffuse scleroderma 10.0 TNFRSF25 TNFRSF10B
42 hyperthyroxinemia 9.9 TSHR TRH TPO SERPINA7
43 adenoma 9.9
44 immune system disease 9.9 TSHR TPO TNFRSF25 TG
45 thyroiditis 9.8 TSHR TRH TPO TG SERPINA7
46 hyperthyroidism 9.8 TSHR TRH TPO TG SERPINA7
47 autoimmune disease of endocrine system 9.8 TSHR TPO TNFRSF25 TG SERPINA7
48 diabetes mellitus, insulin-dependent 9.8 TPO TNFRSF25 TG
49 graves disease 1 9.7 TSHR TRH TPO TG SERPINA7 DIO2
50 thyroid gland disease 9.6 TSHR TRH TPO TG SERPINA7 DIO2

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to Toxic Diffuse Goiter

Symptoms & Phenotypes for Toxic Diffuse Goiter

MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.23 ABCA1 DIO2 S100A6 TG TNFRSF25 TPO

Drugs & Therapeutics for Toxic Diffuse Goiter

Search Clinical Trials , NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

Anatomical Context for Toxic Diffuse Goiter

MalaCards organs/tissues related to Toxic Diffuse Goiter:

41
Thyroid, Whole Blood, T Cells

Publications for Toxic Diffuse Goiter

Articles related to Toxic Diffuse Goiter:

(show all 22)
# Title Authors Year
1
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. ( 21660794 )
2012
2
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. ( 3413443 )
1988
3
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. ( 2445808 )
1987
4
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. ( 6131902 )
1983
5
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. ( 6162933 )
1981
6
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. ( 94089 )
1979
7
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. ( 627898 )
1978
8
The choice of therapy in toxic diffuse goiter. ( 80165 )
1978
9
Iodinating activity of thyroid tissue in toxic diffuse goiter. ( 576614 )
1977
10
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. ( 69022 )
1977
11
I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. ( 4665962 )
1972
12
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. ( 5281463 )
1971
13
Treatment of toxic diffuse goiter. ( 4183010 )
1969
14
I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. ( 5257435 )
1969
15
Toxic diffuse goiter in children. ( 5819609 )
1969
16
Chronic treatment of toxic diffuse goiter. ( 13457490 )
1957
17
The history of the use of iodine in toxic diffuse goiter (Graves' disease). ( 13457495 )
1957
18
Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. ( 14929372 )
1952
19
Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. ( 14810187 )
1951
20
Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. ( 14771065 )
1950
21
Problem cases of toxic diffuse goiter treated with radioactive iodine. ( 18146931 )
1949
22
The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. ( 21002593 )
1946

Variations for Toxic Diffuse Goiter

Expression for Toxic Diffuse Goiter

Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for Toxic Diffuse Goiter

GO Terms for Toxic Diffuse Goiter

Cellular components related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.81 ABCA1 DIO2 S100A6 TDG TNFRSF10B TNFRSF25
2 extracellular region GO:0005576 9.5 C6orf15 PTN S100A6 SERPINA7 TG TNFRSF25
3 cell surface GO:0009986 9.02 ABCA1 PTN TNFRSF10B TPO TSHR

Biological processes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.73 S100A6 TG TNFRSF10B TNFRSF25 TRH TSHR
2 cell surface receptor signaling pathway GO:0007166 9.54 TNFRSF10B TNFRSF25 TSHR
3 hormone-mediated signaling pathway GO:0009755 9.32 TRH TSHR
4 thyroid hormone generation GO:0006590 9.16 DIO2 TPO
5 thyroid hormone metabolic process GO:0042403 8.96 DIO2 TG
6 hormone biosynthetic process GO:0042446 8.8 DIO2 TG TPO

Molecular functions related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 8.8 TNFRSF10B TNFRSF25 TSHR

Sources for Toxic Diffuse Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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