MCID: TXC004
MIFTS: 27

Toxic Diffuse Goiter

Categories: Endocrine diseases

Aliases & Classifications for Toxic Diffuse Goiter

MalaCards integrated aliases for Toxic Diffuse Goiter:

Name: Toxic Diffuse Goiter 12 56 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10719
ICD9CM 36 242.00

Summaries for Toxic Diffuse Goiter

MalaCards based summary : Toxic Diffuse Goiter is related to graves' disease and goiter. An important gene associated with Toxic Diffuse Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Amine-derived hormones. Affiliated tissues include thyroid, t cells and whole blood, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Related Diseases for Toxic Diffuse Goiter

Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 graves' disease 33.1 DIO2 SERPINA7 TG TPO TSHR
2 goiter 30.5 SERPINA7 TG TPO TRH TSHR
3 plummer's disease 30.3 TG TPO
4 nodular goiter 30.2 TG TPO TSHR
5 graves disease 1 29.5 DIO2 SERPINA7 TG TPO TRH TSHR
6 hypothyroidism 29.3 DIO2 SERPINA7 TG TPO TRH TSHR
7 subacute lymphocytic thyroiditis 10.3 TG TPO
8 familial thyroid dyshormonogenesis 10.3 TG TPO
9 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.3 TG TPO
10 hashimoto encephalopathy 10.3 TPO TSHR
11 benign struma ovarii 10.3 TG TSHR
12 struma ovarii 10.3 TG TSHR
13 athyreosis 10.3 TG TSHR
14 premature menopause 10.3 TG TPO
15 pernicious anemia 10.2 TG TPO
16 dyshormonogenic goiter 10.2 SERPINA7 TG
17 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.2 TG TPO
18 myxedema 10.2 TG TPO TSHR
19 euthyroid sick syndrome 10.2 DIO2 SERPINA7
20 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2 TG TPO TSHR
21 multinodular goiter 10.2 TG TPO TSHR
22 follicular adenoma 10.2 TG TPO TSHR
23 papillary carcinoma 10.2 TG TPO TSHR
24 differentiated thyroid carcinoma 10.2 TG TPO TSHR
25 thyroid crisis 10.2 SERPINA7 TG
26 hypothyroidism, congenital, nongoitrous, 2 10.1 SERPINA7 TG TSHR
27 hashimoto thyroiditis 10.1 TG TPO TSHR
28 papillary thyroid microcarcinoma 10.1 TG TSHR
29 postsurgical hypothyroidism 10.1 TG TRH TSHR
30 thyroid hormone resistance, generalized, autosomal dominant 10.1 SERPINA7 TG TRH
31 exophthalmos 10.0 TG TSHR
32 thyroid cancer, nonmedullary, 2 10.0 DIO2 TG TPO TSHR
33 thyroid cancer 10.0 DIO2 TG TPO TSHR
34 celiac disease 1 10.0 TG TNFRSF25 TPO
35 endemic goiter 10.0 SERPINA7 TG TPO TSHR
36 nontoxic goiter 10.0 SERPINA7 TG TPO TSHR
37 subacute thyroiditis 10.0 SERPINA7 TG TPO TSHR
38 congenital hypothyroidism 10.0 SERPINA7 TG TPO TSHR
39 adenoma 9.9
40 hypothyroidism, congenital, nongoitrous, 4 9.9 SERPINA7 TG TPO TRH
41 diffuse scleroderma 9.9 TNFRSF10B TNFRSF25
42 immune system disease 9.9 TG TNFRSF25 TSHR
43 hyperthyroxinemia 9.9 SERPINA7 TPO TRH TSHR
44 chromophobe adenoma 9.8 SERPINA7 TRH
45 thyroiditis 9.7 SERPINA7 TG TPO TRH TSHR
46 hyperthyroidism 9.7 SERPINA7 TG TPO TRH TSHR
47 autoimmune disease of endocrine system 9.6 SERPINA7 TG TNFRSF25 TPO TSHR
48 thyroid gland disease 9.4 C6orf15 DIO2 SERPINA7 TG TPO TRH

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to Toxic Diffuse Goiter

Symptoms & Phenotypes for Toxic Diffuse Goiter

MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.5 ABCA1 DIO2 TG TNFRSF25 TPO TRH
2 growth/size/body region MP:0005378 9.23 ABCA1 C6orf15 DIO2 F3 TG TPO

Drugs & Therapeutics for Toxic Diffuse Goiter

Search Clinical Trials , NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

Anatomical Context for Toxic Diffuse Goiter

MalaCards organs/tissues related to Toxic Diffuse Goiter:

42
Thyroid, T Cells, Whole Blood

Publications for Toxic Diffuse Goiter

Articles related to Toxic Diffuse Goiter:

(show all 22)
# Title Authors Year
1
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. ( 21660794 )
2012
2
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. ( 3413443 )
1988
3
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. ( 2445808 )
1987
4
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. ( 6131902 )
1983
5
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. ( 6162933 )
1981
6
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. ( 94089 )
1979
7
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. ( 627898 )
1978
8
The choice of therapy in toxic diffuse goiter. ( 80165 )
1978
9
Iodinating activity of thyroid tissue in toxic diffuse goiter. ( 576614 )
1977
10
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. ( 69022 )
1977
11
I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. ( 4665962 )
1972
12
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. ( 5281463 )
1971
13
Toxic diffuse goiter in children. ( 5819609 )
1969
14
I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. ( 5257435 )
1969
15
Treatment of toxic diffuse goiter. ( 4183010 )
1969
16
Chronic treatment of toxic diffuse goiter. ( 13457490 )
1957
17
The history of the use of iodine in toxic diffuse goiter (Graves' disease). ( 13457495 )
1957
18
Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. ( 14929372 )
1952
19
Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. ( 14810187 )
1951
20
Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. ( 14771065 )
1950
21
Problem cases of toxic diffuse goiter treated with radioactive iodine. ( 18146931 )
1949
22
The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. ( 21002593 )
1946

Variations for Toxic Diffuse Goiter

Expression for Toxic Diffuse Goiter

Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for Toxic Diffuse Goiter

GO Terms for Toxic Diffuse Goiter

Cellular components related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.81 ABCA1 DIO2 F3 TDG TNFRSF10B TNFRSF25
2 extracellular region GO:0005576 9.5 C6orf15 F3 PTN SERPINA7 TG TNFRSF25
3 cell surface GO:0009986 9.1 ABCA1 F3 PTN TNFRSF10B TPO TSHR

Biological processes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone-mediated signaling pathway GO:0009755 9.26 TRH TSHR
2 thyroid hormone generation GO:0006590 9.16 DIO2 TPO
3 thyroid hormone metabolic process GO:0042403 8.96 DIO2 TG
4 hormone biosynthetic process GO:0042446 8.8 DIO2 TG TPO

Molecular functions related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 8.8 TNFRSF10B TNFRSF25 TSHR

Sources for Toxic Diffuse Goiter

3 CDC
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10 dbSNP
11 DGIdb
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29 GO
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34 ICD10
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63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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