MCID: TXC004
MIFTS: 25

Toxic Diffuse Goiter

Categories: Endocrine diseases

Aliases & Classifications for Toxic Diffuse Goiter

MalaCards integrated aliases for Toxic Diffuse Goiter:

Name: Toxic Diffuse Goiter 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10719
ICD9CM 35 242.00

Summaries for Toxic Diffuse Goiter

MalaCards based summary : Toxic Diffuse Goiter is related to graves' disease and plummer's disease. An important gene associated with Toxic Diffuse Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Amine-derived hormones and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid and whole blood, and related phenotype is endocrine/exocrine gland.

Related Diseases for Toxic Diffuse Goiter

Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 graves' disease 32.5 DIO2 SERPINA7 TG TPO TSHR
2 plummer's disease 30.6 TG TPO
3 nodular goiter 30.3 TG TPO TSHR
4 goiter 30.0 SERPINA7 TG TPO TRH TSHR
5 thyroiditis 29.2 SERPINA7 TG TPO TRH TSHR
6 hypothyroidism 28.4 DIO2 SERPINA7 TG TPO TRH TSHR
7 familial thyroid dyshormonogenesis 10.8 TG TPO
8 subacute lymphocytic thyroiditis 10.7 TG TPO
9 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.7 TG TPO
10 benign struma ovarii 10.6 TG TSHR
11 athyreosis 10.6 TG TSHR
12 premature menopause 10.6 TG TPO
13 dyshormonogenic goiter 10.6 SERPINA7 TG
14 hypothyroidism, congenital, nongoitrous, 4 10.6 TG TPO
15 struma ovarii 10.6 TG TSHR
16 pernicious anemia 10.6 TG TPO
17 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.5 TG TPO
18 euthyroid sick syndrome 10.5 DIO2 SERPINA7
19 neonatal hypothyroidism 10.4 TG TPO TSHR
20 papillary thyroid microcarcinoma 10.4 TG TSHR
21 myxedema 10.4 TG TPO TSHR
22 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4 TG TPO TSHR
23 multinodular goiter 10.4 TG TPO TSHR
24 follicular adenoma 10.4 TG TPO TSHR
25 exophthalmos 10.4 TG TSHR
26 congenital hypothyroidism 10.4 TG TPO TSHR
27 papillary carcinoma 10.4 TG TPO TSHR
28 differentiated thyroid carcinoma 10.3 TG TPO TSHR
29 hashimoto thyroiditis 10.3 TG TPO TSHR
30 hypothyroidism, congenital, nongoitrous, 2 10.3 SERPINA7 TG TSHR
31 thyroid hormone resistance, generalized, autosomal dominant 10.2 SERPINA7 TG TRH
32 endocrine organ benign neoplasm 10.2 TG TRH
33 chromophobe adenoma 10.1 SERPINA7 TRH
34 thyroid cancer, nonmedullary, 2 10.0 DIO2 TG TPO TSHR
35 endemic goiter 10.0 SERPINA7 TG TPO TSHR
36 nontoxic goiter 10.0 SERPINA7 TG TPO TSHR
37 subacute thyroiditis 10.0 SERPINA7 TG TPO TSHR
38 anaplastic thyroid cancer 10.0 TG TPO
39 celiac disease 1 10.0 TG TNFRSF25 TPO
40 diffuse scleroderma 9.9 TNFRSF10B TNFRSF25
41 thyroid cancer 9.9 DIO2 TG TPO TSHR
42 immune system disease 9.9 TG TNFRSF25 TSHR
43 adenoma 9.8
44 hyperthyroxinemia 9.8 SERPINA7 TPO TRH TSHR
45 hypersensitivity reaction disease 9.7 TG TNFRSF25 TPO TSHR
46 hyperthyroidism 9.5 SERPINA7 TG TPO TRH TSHR
47 diabetes mellitus, insulin-dependent 9.5 TG TNFRSF25 TPO
48 autoimmune disease of endocrine system 9.3 SERPINA7 TG TNFRSF25 TPO TSHR
49 graves disease 1 9.2 DIO2 SERPINA7 TG TPO TRH TSHR
50 thyroid gland disease 9.2 DIO2 SERPINA7 TG TPO TRH TSHR

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to Toxic Diffuse Goiter

Symptoms & Phenotypes for Toxic Diffuse Goiter

MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.23 ABCA1 DIO2 S100A6 TG TNFRSF25 TPO

Drugs & Therapeutics for Toxic Diffuse Goiter

Search Clinical Trials , NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

Anatomical Context for Toxic Diffuse Goiter

MalaCards organs/tissues related to Toxic Diffuse Goiter:

41
Thyroid, Whole Blood

Publications for Toxic Diffuse Goiter

Articles related to Toxic Diffuse Goiter:

(show all 24)
# Title Authors Year
1
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. ( 21660794 )
2012
2
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. ( 12213665 )
2002
3
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. ( 7951488 )
1993
4
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. ( 3413443 )
1988
5
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. ( 2445808 )
1987
6
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. ( 6131902 )
1983
7
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. ( 6162933 )
1981
8
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. ( 94089 )
1979
9
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. ( 627898 )
1978
10
The choice of therapy in toxic diffuse goiter. ( 80165 )
1978
11
Iodinating activity of thyroid tissue in toxic diffuse goiter. ( 576614 )
1977
12
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. ( 69022 )
1977
13
I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. ( 4665962 )
1972
14
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. ( 5281463 )
1971
15
Treatment of toxic diffuse goiter. ( 4183010 )
1969
16
I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. ( 5257435 )
1969
17
Toxic diffuse goiter in children. ( 5819609 )
1969
18
Chronic treatment of toxic diffuse goiter. ( 13457490 )
1957
19
The history of the use of iodine in toxic diffuse goiter (Graves' disease). ( 13457495 )
1957
20
Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. ( 14929372 )
1952
21
Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. ( 14810187 )
1951
22
Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. ( 14771065 )
1950
23
Problem cases of toxic diffuse goiter treated with radioactive iodine. ( 18146931 )
1949
24
The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. ( 21002593 )
1946

Variations for Toxic Diffuse Goiter

Expression for Toxic Diffuse Goiter

Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for Toxic Diffuse Goiter

Pathways related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.56 DIO2 TPO
2 9.7 TG TPO TRH TSHR

GO Terms for Toxic Diffuse Goiter

Cellular components related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.81 ABCA1 DIO2 S100A6 TDG TNFRSF10B TNFRSF25
2 extracellular region GO:0005576 9.5 C6orf15 PTN S100A6 SERPINA7 TG TNFRSF25
3 cell surface GO:0009986 9.02 ABCA1 PTN TNFRSF10B TPO TSHR

Biological processes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone-mediated signaling pathway GO:0009755 9.26 TRH TSHR
2 thyroid hormone generation GO:0006590 9.16 DIO2 TPO
3 thyroid hormone metabolic process GO:0042403 8.96 DIO2 TG
4 hormone biosynthetic process GO:0042446 8.8 DIO2 TG TPO

Molecular functions related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.13 TNFRSF10B TNFRSF25 TSHR
2 tumor necrosis factor-activated receptor activity GO:0005031 8.62 TNFRSF10B TNFRSF25

Sources for Toxic Diffuse Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....