MCID: TXC004
MIFTS: 27

Toxic Diffuse Goiter

Categories: Endocrine diseases

Aliases & Classifications for Toxic Diffuse Goiter

MalaCards integrated aliases for Toxic Diffuse Goiter:

Name: Toxic Diffuse Goiter 12 55 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:10719
ICD9CM 35 242.00
UMLS 72 C0154138 C0342122

Summaries for Toxic Diffuse Goiter

MalaCards based summary : Toxic Diffuse Goiter is related to graves' disease and plummer's disease. An important gene associated with Toxic Diffuse Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Amine-derived hormones. Affiliated tissues include thyroid, testes and bone, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Related Diseases for Toxic Diffuse Goiter

Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 graves' disease 33.0 TSHR TPO TG SERPINA7 DIO2
2 plummer's disease 30.6 TPO TG
3 goiter 30.4 TSHR TRH TPO TG SERPINA7
4 nodular goiter 30.3 TSHR TPO TG
5 hyperthyroidism 29.3 TSHR TRH TPO TG SERPINA7
6 graves disease 1 29.2 TSHR TRH TPO TG SERPINA7 DIO2
7 hypothyroidism 29.2 TSHR TRH TPO TG SERPINA7 DIO2
8 subacute lymphocytic thyroiditis 10.6 TPO TG
9 familial thyroid dyshormonogenesis 10.5 TPO TG
10 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.5 TPO TG
11 hashimoto encephalopathy 10.5 TSHR TPO
12 benign struma ovarii 10.5 TSHR TG
13 struma ovarii 10.5 TSHR TG
14 athyreosis 10.4 TSHR TG
15 premature menopause 10.4 TPO TG
16 dyshormonogenic goiter 10.4 TG SERPINA7
17 pernicious anemia 10.3 TPO TG
18 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.3 TPO TG
19 myxedema 10.3 TSHR TPO TG
20 euthyroid sick syndrome 10.3 SERPINA7 DIO2
21 thyroid crisis 10.3 TG SERPINA7
22 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3 TSHR TPO TG
23 multinodular goiter 10.3 TSHR TPO TG
24 follicular adenoma 10.3 TSHR TPO TG
25 papillary carcinoma 10.3 TSHR TPO TG
26 differentiated thyroid carcinoma 10.3 TSHR TPO TG
27 hypothyroidism, congenital, nongoitrous, 2 10.2 TSHR TG SERPINA7
28 hashimoto thyroiditis 10.2 TSHR TPO TG
29 papillary thyroid microcarcinoma 10.2 TSHR TG
30 postsurgical hypothyroidism 10.2 TSHR TRH TG
31 thyroid hormone resistance, generalized, autosomal dominant 10.1 TRH TG SERPINA7
32 adenoma 10.1
33 exophthalmos 10.1 TSHR TG
34 celiac disease 1 10.0 TPO TNFRSF25 TG
35 thyroid cancer, nonmedullary, 2 10.0 TSHR TPO TG DIO2
36 endemic goiter 10.0 TSHR TPO TG SERPINA7
37 nontoxic goiter 10.0 TSHR TPO TG SERPINA7
38 subacute thyroiditis 10.0 TSHR TPO TG SERPINA7
39 congenital hypothyroidism 9.9 TSHR TPO TG SERPINA7
40 hypothyroidism, congenital, nongoitrous, 4 9.9 TRH TPO TG SERPINA7
41 diffuse scleroderma 9.9 TNFRSF25 TNFRSF10B
42 immune system disease 9.9 TSHR TNFRSF25 TG
43 hyperthyroxinemia 9.8 TSHR TRH TPO SERPINA7
44 chromophobe adenoma 9.7 TRH SERPINA7
45 thyroiditis 9.6 TSHR TRH TPO TG SERPINA7
46 autoimmune disease of endocrine system 9.4 TSHR TPO TNFRSF25 TG SERPINA7
47 thyroid gland disease 9.0 TSHR TRH TPO TG SERPINA7 DIO2

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to Toxic Diffuse Goiter

Symptoms & Phenotypes for Toxic Diffuse Goiter

MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.5 ABCA1 DIO2 TG TNFRSF25 TPO TRH
2 growth/size/body region MP:0005378 9.23 ABCA1 C6orf15 DIO2 F3 TG TPO

Drugs & Therapeutics for Toxic Diffuse Goiter

Search Clinical Trials , NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

Anatomical Context for Toxic Diffuse Goiter

MalaCards organs/tissues related to Toxic Diffuse Goiter:

41
Thyroid, Testes, Bone, Whole Blood

Publications for Toxic Diffuse Goiter

Articles related to Toxic Diffuse Goiter:

(show top 50) (show all 69)
# Title Authors PMID Year
1
Prevalence of thyroid microsomal and thyroglobulin autoantibodies in goitrous lesions. 9 38
11873391 2001
2
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. 9 38
7951488 1993
3
[Prediction of activity and severity of endocrine ophthalmopathy by multidimensional linear regression modeling]. 38
29771881 2018
4
Positive correlation between type 1 and 2 iodothyronine deiodinases activities in human goiters. 38
22207295 2012
5
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. 38
21660794 2012
6
Endocrine orbitopathy (Graves disease): transpalpebral fat decompression in combination with 3-wall bony expansion. 38
20613619 2010
7
Analysis of surgical complications of thyroid diseases: results of a single institution. 38
19408826 2009
8
Concomitant hyperthyroidism in patients with thyroid carcinoma and the effects of iodine supplementation in an iodine-deficient area. 38
18936609 2008
9
The newly developed three-dimensional (3D) and two-dimensional (2D) thyroid ultrasound are strongly correlated, but 2D overestimates thyroid volume in the presence of nodules. 38
16794365 2006
10
Incidental thyroid carcinoma in a large series of consecutive patients operated on for benign thyroid disease. 38
16626346 2006
11
Clinical aspects of hyperthyroidism in hospitalised patients in Albania. 38
16982578 2004
12
The prevalence of elevated serum C-reactive protein levels in inflammatory and noninflammatory thyroid disease. 38
12964969 2003
13
Radioiodine treatment of hyperthyroidism. Success rate and influence of thyrostatic medication. 38
12754531 2003
14
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. 9
12213665 2002
15
Prevalence of thyroid diseases in patients with acromegaly: results of an Italian multi-center study. 38
11936466 2002
16
Goiter and hypothyroidism in two siblings due to impaired Ca(+2)/NAD(P)H-dependent H(2)O(2)-generating activity. 9
11600551 2001
17
Ca(2+)/nicotinamide adenine dinucleotide phosphate-dependent H(2)O(2) generation is inhibited by iodide in human thyroids. 9
11549671 2001
18
Thyrotoxicosis: clinical and laboratory assessment. 38
10509130 1999
19
The spectrum of thyroid disorders in an iodine-deficient community: the Pescopagano survey. 38
10022416 1999
20
Comparison of the outcome between the calculated dosimetry and the estimated dosimetry of 131I in the treatment of hyperthyroidism. 38
8851980 1995
21
[Anti-microsomal, anti-thyroglobulin antibodies and thyroid stimulants in hyperthyroid subjects. Analysis of 315 patients followed-up for 3 years at a single medical center]. 38
7855385 1994
22
Peroxidase and coupling activities of thyroid peroxidase in benign and malignant thyroid tumor tissues. 9
1422230 1992
23
Activation of blood coagulation and fibrinolysis in Graves' disease. 38
1778596 1991
24
[Determination of autoantibodies to thyrotropin receptors in patients with diffuse toxic goiter]. 9
1658772 1991
25
Incidence of carcinoma of the thyroid in nodular goiter. 38
2034940 1991
26
[Parathyroid function in hyperthyroidism: implications for bone metabolism and effect of the treatment]. 38
1909454 1991
27
[Results of studies performed with the MZ-XVII program on a national scale; summary and conclusions]. 38
1364484 1991
28
Changes in serum thyroid hormone and thyroglobulin levels after surgical treatments for toxic and non-toxic goiter. 38
2484876 1989
29
[Thyroid microsomal autoantibodies in thyroid disease: their value as an antigenic marker]. 38
2519389 1989
30
Somatostatin in medullary thyroid cancer. In vitro and in vivo studies. 38
2563668 1989
31
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. 38
3413443 1988
32
Thyroid carcinoma in thyrotoxic patients treated by surgery. 38
3361079 1988
33
Plasma membrane shedding and colloid vacuoles in hyperactive human thyroid tissue. 38
2907207 1988
34
Effects of thyroid stimulating immunoglobulin on function and morphology of xenotransplanted toxic diffuse, toxic nodular and normal thyroid tissue. 38
2892875 1987
35
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. 38
2445808 1987
36
Ultrastructural localization of endogenous peroxidase activity in benign thyroid diseases. 38
3630696 1987
37
[Peroxidase activity of thyroid tissue in toxic diffuse goiter. Difference among thyroids administered antithyroid drugs and potassium iodide]. 38
3754518 1986
38
A high prevalence of thyroglobulin autoantibodies in adults with and without thyroid disease as measured with a sensitive solid-phase immunosorbent radioassay. 38
3930112 1985
39
Thyroid carcinoma in benign thyroid diseases. An analysis from minute carcinoma. 38
4072672 1985
40
[Treatment of patients with toxic diffuse goiter]. 38
6417398 1983
41
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. 38
6131902 1983
42
[Effect of obzidan test on blood prolactin level in patients with toxic diffuse goiter]. 38
6897605 1982
43
[Anti-thyroglobulin and anti-thyroid microsomal antibodies in thyroid disorders]. 38
6897219 1982
44
The prevalence of thyroid-stimulating antibodies in goitrous disease assessed by cytochemical section bioassay. 38
6119323 1982
45
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. 38
6162933 1981
46
Serum thyroglobulin in thyroid carcinoma and other thyroid disorders. 38
7430557 1980
47
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. 38
94089 1979
48
[Hemodynamic disorders of the lesser circulation and their correction in primary toxic diffuse goiter in the early postoperative period]. 38
389096 1979
49
[Functional state of the cardiovascular system in primary toxic, diffuse goiter]. 38
581888 1979
50
The choice of therapy in toxic diffuse goiter. 38
80165 1978

Variations for Toxic Diffuse Goiter

Expression for Toxic Diffuse Goiter

Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for Toxic Diffuse Goiter

GO Terms for Toxic Diffuse Goiter

Cellular components related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.81 TSHR TRH TPO TNFRSF25 TNFRSF10B TDG
2 extracellular region GO:0005576 9.5 TRH TNFRSF25 TG SERPINA7 PTN F3
3 cell surface GO:0009986 9.1 TSHR TPO TNFRSF10B PTN F3 ABCA1

Biological processes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone-mediated signaling pathway GO:0009755 9.26 TSHR TRH
2 thyroid hormone generation GO:0006590 9.16 TPO DIO2
3 thyroid hormone metabolic process GO:0042403 8.96 TG DIO2
4 hormone biosynthetic process GO:0042446 8.8 TPO TG DIO2

Molecular functions related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 8.8 TSHR TNFRSF25 TNFRSF10B

Sources for Toxic Diffuse Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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