MCID: TXC009
MIFTS: 19

Toxic Maculopathy

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Toxic Maculopathy

MalaCards integrated aliases for Toxic Maculopathy:

Name: Toxic Maculopathy 12 15 73
Toxic Maculopathy of Retina 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:9867
ICD10 33 H35.38
ICD9CM 35 362.55
SNOMED-CT 68 44115007
UMLS 73 C0271086

Summaries for Toxic Maculopathy

MalaCards based summary : Toxic Maculopathy, also known as toxic maculopathy of retina, is related to toxic maculopathy due to antimalarial drugs and optic neuritis. An important gene associated with Toxic Maculopathy is ABCA4 (ATP Binding Cassette Subfamily A Member 4). The drugs chloroquine and Hydroxychloroquine have been mentioned in the context of this disorder. Affiliated tissues include retina and eye.

Related Diseases for Toxic Maculopathy

Diseases in the Toxic Maculopathy family:

Toxic Maculopathy Due to Antimalarial Drugs

Diseases related to Toxic Maculopathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 toxic maculopathy due to antimalarial drugs 12.3
2 optic neuritis 9.8
3 neuritis 9.8
4 melanoma 9.8

Symptoms & Phenotypes for Toxic Maculopathy

Drugs & Therapeutics for Toxic Maculopathy

Drugs for Toxic Maculopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
chloroquine Approved, Investigational, Vet_approved 54-05-7 2719
2
Hydroxychloroquine Approved 118-42-3 3652
3 Analgesics
4 Anthelmintics
5 Anti-Inflammatory Agents, Non-Steroidal
6 Chloroquine diphosphate 50-63-5
7 Peripheral Nervous System Agents
8 Anti-Infective Agents
9 Antiparasitic Agents
10 Antirheumatic Agents
11 Antiprotozoal Agents
12 Anti-Inflammatory Agents
13 Antimalarials
14 Analgesics, Non-Narcotic

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Incidence and Risk Factor of Hydroxychloroquine and Chloroquine Retinopathy Unknown status NCT02550964

Search NIH Clinical Center for Toxic Maculopathy

Genetic Tests for Toxic Maculopathy

Anatomical Context for Toxic Maculopathy

MalaCards organs/tissues related to Toxic Maculopathy:

41
Retina, Eye

Publications for Toxic Maculopathy

Articles related to Toxic Maculopathy:

# Title Authors Year
1
Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy). ( 25884411 )
2015
2
Regular Examinations for Toxic Maculopathy in Long-term Chloroquine or Hydroxychloroquine Users. ( 24970348 )
2014
3
Poppers toxic maculopathy misdiagnosed as atypical optic neuritis. ( 23750837 )
2013
4
Post-brachytherapy tumor endoresection for treatment of toxic maculopathy in choroidal melanoma. ( 23743528 )
2013
5
Fluphenazine and its toxic maculopathy. ( 15292663 )
2004
6
Toxic maculopathy. Part I. A result of quinine usage. ( 1190657 )
1975
7
Toxic maculopathy part II: A result of quinine usage as demonstrated by fluorescein angiography and electroretinography. ( 1200559 )
1975

Variations for Toxic Maculopathy

Expression for Toxic Maculopathy

Search GEO for disease gene expression data for Toxic Maculopathy.

Pathways for Toxic Maculopathy

GO Terms for Toxic Maculopathy

Sources for Toxic Maculopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....