MCID: TXC009
MIFTS: 20

Toxic Maculopathy

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Toxic Maculopathy

MalaCards integrated aliases for Toxic Maculopathy:

Name: Toxic Maculopathy 12 15 72
Toxic Maculopathy of Retina 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:9867
ICD9CM 35 362.55
SNOMED-CT 68 44115007
ICD10 33 H35.38
UMLS 72 C0271086

Summaries for Toxic Maculopathy

MalaCards based summary : Toxic Maculopathy, also known as toxic maculopathy of retina, is related to toxic maculopathy due to antimalarial drugs and retinal detachment. An important gene associated with Toxic Maculopathy is ABCA4 (ATP Binding Cassette Subfamily A Member 4). The drugs chloroquine and Hydroxychloroquine have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and testes.

Related Diseases for Toxic Maculopathy

Diseases in the Toxic Maculopathy family:

Toxic Maculopathy Due to Antimalarial Drugs

Diseases related to Toxic Maculopathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 toxic maculopathy due to antimalarial drugs 12.4
2 retinal detachment 9.9
3 macular degeneration, age-related, 1 9.9
4 suppression amblyopia 9.9
5 amblyopia 9.9
6 optic neuritis 9.9
7 neovascular glaucoma 9.9
8 neuritis 9.9
9 retinal disease 9.9

Graphical network of the top 20 diseases related to Toxic Maculopathy:



Diseases related to Toxic Maculopathy

Symptoms & Phenotypes for Toxic Maculopathy

Drugs & Therapeutics for Toxic Maculopathy

Drugs for Toxic Maculopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
chloroquine Approved, Investigational, Vet_approved 54-05-7 2719
2
Hydroxychloroquine Approved 118-42-3 3652
3 Analgesics
4 Chloroquine diphosphate 50-63-5
5 Anti-Inflammatory Agents, Non-Steroidal
6 Antiparasitic Agents
7 Analgesics, Non-Narcotic
8 Anti-Infective Agents
9 Peripheral Nervous System Agents
10 Antiprotozoal Agents
11 Anthelmintics
12 Anti-Inflammatory Agents
13 Antimalarials
14 Antirheumatic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Incidence and Risk Factor Evaluation for Toxic Maculopathy Associated With Hydroxychloroquine and Chloroquine Unknown status NCT02550964

Search NIH Clinical Center for Toxic Maculopathy

Genetic Tests for Toxic Maculopathy

Anatomical Context for Toxic Maculopathy

MalaCards organs/tissues related to Toxic Maculopathy:

41
Retina, Eye, Testes

Publications for Toxic Maculopathy

Articles related to Toxic Maculopathy:

(show all 27)
# Title Authors PMID Year
1
Evaluation of Maculopathy in Patients Using Hydroxychloroquine 38
31245977 2019
2
Incidence of blindness in a population of rheumatic patients treated with hydroxychloroquine. 38
31431997 2019
3
Bilateral cystoid macular edema misdiagnosed as pars planitis in a patient on sertraline therapy. 38
29984334 2018
4
FUNDUS AUTOFLUORESCENCE FINDINGS IN EARLY CHLOROQUINE MACULOPATHY. 38
27768637 2018
5
Coding patterns used by ophthalmologists for hydroxychloroquine retinal toxicity. 38
30464387 2018
6
Ocular Involvement in Systemic Lupus Erythematosus: The Experience of Two Tertiary Referral Centers. 38
30096011 2018
7
Toxic retinopathy after phacoemulsification when the cefuroxime dilution is correct. 38
29502614 2018
8
Screening for chloroquine maculopathy in populations with uncertain reliability in outcomes of automatic visual field testing. 38
27905330 2016
9
Poppers Maculopathy: Complete Restitution of Macular Changes in OCT after Drug Abstinence. 38
25398125 2016
10
Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy). 38
25884411 2015
11
Regular examinations for toxic maculopathy in long-term chloroquine or hydroxychloroquine users. 38
24970348 2014
12
Post-brachytherapy tumor endoresection for treatment of toxic maculopathy in choroidal melanoma. 38
23743528 2013
13
Poppers toxic maculopathy misdiagnosed as atypical optic neuritis. 38
23750837 2013
14
Didactic image poppers maculopathy. 38
24923094 2013
15
New trends in early diagnosis of hydroxychloroquine toxic retinopathy. 38
23249122 2012
16
[Ocular complications of chloroquine and derivatives therapy]. 38
20944948 2010
17
Optical coherence tomography findings in deferasirox-related maculopathy. 38
25390664 2010
18
[Toxic maculopathy caused by antimalarial drugs: detection using spectral domain OCT: case reports]. 38
20027416 2009
19
Retinal toxicity secondary to Plaquenil therapy. 38
18215798 2008
20
[Chloroquine/hydroxychloroquine: variability of retinotoxic cumulative doses]. 38
17653725 2007
21
Review of sterile, postoperative, anterior segment inflammation following cataract extraction and intraocular lens implantation. 38
15812764 2005
22
Fluphenazine and its toxic maculopathy. 38
15292663 2004
23
Multifocal electroretinography evaluation for early detection of retinal dysfunction in patients taking hydroxychloroquine. 38
12972762 2003
24
[Macular complications of synthetic antimalarials. Apropos of a case]. 38
7560802 1995
25
[Toxic maculopathy caused by abuse of hydroxyquinoline derivatives? Apropos of a case]. 38
6529835 1984
26
Toxic maculopathy part II: A result of quinine usage as demonstrated by fluorescein angiography and electroretinography. 38
1200559 1975
27
Toxic maculopathy. Part I. A result of quinine usage. 38
1190657 1975

Variations for Toxic Maculopathy

Expression for Toxic Maculopathy

Search GEO for disease gene expression data for Toxic Maculopathy.

Pathways for Toxic Maculopathy

GO Terms for Toxic Maculopathy

Sources for Toxic Maculopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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