MCID: TXC009
MIFTS: 19

Toxic Maculopathy

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Toxic Maculopathy

MalaCards integrated aliases for Toxic Maculopathy:

Name: Toxic Maculopathy 12 15 74
Toxic Maculopathy of Retina 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:9867
ICD9CM 36 362.55
SNOMED-CT 69 44115007
ICD10 34 H35.38
UMLS 74 C0271086

Summaries for Toxic Maculopathy

MalaCards based summary : Toxic Maculopathy, also known as toxic maculopathy of retina, is related to toxic maculopathy due to antimalarial drugs and optic neuritis. An important gene associated with Toxic Maculopathy is ABCA4 (ATP Binding Cassette Subfamily A Member 4). The drugs Hydroxychloroquine and chloroquine have been mentioned in the context of this disorder. Affiliated tissues include retina and eye.

Related Diseases for Toxic Maculopathy

Diseases in the Toxic Maculopathy family:

Toxic Maculopathy Due to Antimalarial Drugs

Diseases related to Toxic Maculopathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 toxic maculopathy due to antimalarial drugs 12.3
2 optic neuritis 9.8
3 neuritis 9.8
4 melanoma 9.8

Symptoms & Phenotypes for Toxic Maculopathy

Drugs & Therapeutics for Toxic Maculopathy

Drugs for Toxic Maculopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxychloroquine Approved 118-42-3 3652
2
chloroquine Approved, Investigational, Vet_approved 54-05-7 2719
3 Anti-Infective Agents
4 Antiparasitic Agents
5 Peripheral Nervous System Agents
6 Analgesics
7 Antiprotozoal Agents
8 Anti-Inflammatory Agents
9 Antimalarials
10 Analgesics, Non-Narcotic
11 Chloroquine diphosphate 50-63-5
12 Anti-Inflammatory Agents, Non-Steroidal
13 Anthelmintics
14 Antirheumatic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Incidence and Risk Factor of Hydroxychloroquine and Chloroquine Retinopathy Unknown status NCT02550964

Search NIH Clinical Center for Toxic Maculopathy

Genetic Tests for Toxic Maculopathy

Anatomical Context for Toxic Maculopathy

MalaCards organs/tissues related to Toxic Maculopathy:

42
Retina, Eye

Publications for Toxic Maculopathy

Articles related to Toxic Maculopathy:

# Title Authors Year
1
Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy). ( 25884411 )
2015
2
Regular examinations for toxic maculopathy in long-term chloroquine or hydroxychloroquine users. ( 24970348 )
2014
3
Poppers toxic maculopathy misdiagnosed as atypical optic neuritis. ( 23750837 )
2013
4
Post-brachytherapy tumor endoresection for treatment of toxic maculopathy in choroidal melanoma. ( 23743528 )
2013
5
Fluphenazine and its toxic maculopathy. ( 15292663 )
2004
6
Toxic maculopathy. Part I. A result of quinine usage. ( 1190657 )
1975
7
Toxic maculopathy part II: A result of quinine usage as demonstrated by fluorescein angiography and electroretinography. ( 1200559 )
1975

Variations for Toxic Maculopathy

Expression for Toxic Maculopathy

Search GEO for disease gene expression data for Toxic Maculopathy.

Pathways for Toxic Maculopathy

GO Terms for Toxic Maculopathy

Sources for Toxic Maculopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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