MCID: TXC009
MIFTS: 24

Toxic Maculopathy

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Toxic Maculopathy

MalaCards integrated aliases for Toxic Maculopathy:

Name: Toxic Maculopathy 12 15 71
Toxic Maculopathy of Retina 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:9867
ICD9CM 34 362.55
SNOMED-CT 67 44115007
ICD10 32 H35.38
UMLS 71 C0271086

Summaries for Toxic Maculopathy

MalaCards based summary : Toxic Maculopathy, also known as toxic maculopathy of retina, is related to retinal disease and toxic maculopathy due to antimalarial drugs. An important gene associated with Toxic Maculopathy is ABCA4 (ATP Binding Cassette Subfamily A Member 4). The drugs Hydroxychloroquine and chloroquine have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and testes, and related phenotype is nervous system.

Related Diseases for Toxic Maculopathy

Diseases in the Toxic Maculopathy family:

Toxic Maculopathy Due to Antimalarial Drugs

Diseases related to Toxic Maculopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 retinal disease 29.6 CFH ARMS2 ABCA4
2 toxic maculopathy due to antimalarial drugs 12.4
3 multifocal choroiditis 10.3 CFH ARMS2
4 partial central choroid dystrophy 10.3 TAP1 ABCA4
5 choroiditis 10.3 CFH ARMS2
6 hereditary choroidal atrophy 10.3 TAP1 ABCA4
7 central serous chorioretinopathy 10.3 CFH ARMS2
8 bullous retinoschisis 10.3 CFH ARMS2
9 macular degeneration, age-related, 6 10.3 CFH ABCA4
10 macular degeneration, age-related, 4 10.3 CFH ABCA4
11 kuhnt-junius degeneration 10.3 CFH ARMS2
12 angioid streaks 10.2 CFH ARMS2
13 yemenite deaf-blind hypopigmentation syndrome 10.2 CFH ABCA4
14 complement component 2 deficiency 10.2 CFH ARMS2
15 histoplasmosis 10.2 CFH ARMS2
16 basal laminar drusen 10.2 CFH ARMS2 ABCA4
17 retinal drusen 10.2 CFH ARMS2 ABCA4
18 doyne honeycomb retinal dystrophy 10.2 CFH ARMS2 ABCA4
19 degeneration of macula and posterior pole 10.2 CFH ARMS2 ABCA4
20 stargardt disease 10.1 CFH ARMS2 ABCA4
21 choroidal dystrophy, central areolar, 1 10.0 TAP1 ABCA4
22 retinal detachment 9.9
23 macular degeneration, age-related, 1 9.9
24 suppression amblyopia 9.9
25 amblyopia 9.9
26 optic neuritis 9.9
27 neovascular glaucoma 9.9
28 neuritis 9.9
29 childhood electroclinical syndrome 9.8 MLST8 CACNA1A
30 photosensitive epilepsy 9.8 CACNA1A BRD2
31 contractures, pterygia, and variable skeletal fusions syndrome 1a 9.8 CFH CACNA1A ARMS2 ABCA4
32 autosomal genetic disease 9.8 CFH CACNA1A ARMS2 ABCA4
33 ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia 9.5 FEN1 CACNA1A

Graphical network of the top 20 diseases related to Toxic Maculopathy:



Diseases related to Toxic Maculopathy

Symptoms & Phenotypes for Toxic Maculopathy

MGI Mouse Phenotypes related to Toxic Maculopathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.28 ABCA4 BRD2 CACNA1A CFH FEN1 MLST8

Drugs & Therapeutics for Toxic Maculopathy

Drugs for Toxic Maculopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxychloroquine Approved 118-42-3 3652
2
chloroquine Approved, Investigational, Vet_approved 54-05-7 2719
3 Anti-Inflammatory Agents
4 Anti-Infective Agents
5 Anti-Inflammatory Agents, Non-Steroidal
6 Analgesics, Non-Narcotic
7 Antiparasitic Agents
8 Antiprotozoal Agents
9 Antirheumatic Agents
10 Chloroquine diphosphate 50-63-5
11 Antimalarials
12 Anthelmintics
13 Analgesics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Incidence and Risk Factor Evaluation for Toxic Maculopathy Associated With Hydroxychloroquine and Chloroquine Unknown status NCT02550964

Search NIH Clinical Center for Toxic Maculopathy

Genetic Tests for Toxic Maculopathy

Anatomical Context for Toxic Maculopathy

MalaCards organs/tissues related to Toxic Maculopathy:

40
Retina, Eye, Testes

Publications for Toxic Maculopathy

Articles related to Toxic Maculopathy:

(show all 28)
# Title Authors PMID Year
1
Pentosan Polysulfate Sodium Exposure and Drug-Induced Maculopathy in Commercially Insured Patients in the United States. 61
31899034 2019
2
Evaluation of Maculopathy in Patients Using Hydroxychloroquine 61
31245977 2019
3
Incidence of blindness in a population of rheumatic patients treated with hydroxychloroquine. 61
31431997 2019
4
Bilateral cystoid macular edema misdiagnosed as pars planitis in a patient on sertraline therapy. 61
29984334 2018
5
FUNDUS AUTOFLUORESCENCE FINDINGS IN EARLY CHLOROQUINE MACULOPATHY. 61
27768637 2018
6
Coding patterns used by ophthalmologists for hydroxychloroquine retinal toxicity. 61
30464387 2018
7
Ocular Involvement in Systemic Lupus Erythematosus: The Experience of Two Tertiary Referral Centers. 61
30096011 2018
8
Toxic retinopathy after phacoemulsification when the cefuroxime dilution is correct. 61
29502614 2018
9
Screening for chloroquine maculopathy in populations with uncertain reliability in outcomes of automatic visual field testing. 61
27905330 2016
10
Poppers Maculopathy: Complete Restitution of Macular Changes in OCT after Drug Abstinence. 61
25398125 2016
11
Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy). 61
25884411 2015
12
Regular examinations for toxic maculopathy in long-term chloroquine or hydroxychloroquine users. 61
24970348 2014
13
Post-brachytherapy tumor endoresection for treatment of toxic maculopathy in choroidal melanoma. 61
23743528 2013
14
Poppers toxic maculopathy misdiagnosed as atypical optic neuritis. 61
23750837 2013
15
Didactic image poppers maculopathy. 61
24923094 2013
16
New trends in early diagnosis of hydroxychloroquine toxic retinopathy. 61
23249122 2012
17
[Ocular complications of chloroquine and derivatives therapy]. 61
20944948 2010
18
Optical coherence tomography findings in deferasirox-related maculopathy. 61
25390664 2010
19
[Toxic maculopathy caused by antimalarial drugs: detection using spectral domain OCT: case reports]. 61
20027416 2009
20
Retinal toxicity secondary to Plaquenil therapy. 61
18215798 2008
21
[Chloroquine/hydroxychloroquine: variability of retinotoxic cumulative doses]. 61
17653725 2007
22
Review of sterile, postoperative, anterior segment inflammation following cataract extraction and intraocular lens implantation. 61
15812764 2005
23
Fluphenazine and its toxic maculopathy. 61
15292663 2004
24
Multifocal electroretinography evaluation for early detection of retinal dysfunction in patients taking hydroxychloroquine. 61
12972762 2003
25
[Macular complications of synthetic antimalarials. Apropos of a case]. 61
7560802 1995
26
[Toxic maculopathy caused by abuse of hydroxyquinoline derivatives? Apropos of a case]. 61
6529835 1984
27
Toxic maculopathy part II: A result of quinine usage as demonstrated by fluorescein angiography and electroretinography. 61
1200559 1975
28
Toxic maculopathy. Part I. A result of quinine usage. 61
1190657 1975

Variations for Toxic Maculopathy

Expression for Toxic Maculopathy

Search GEO for disease gene expression data for Toxic Maculopathy.

Pathways for Toxic Maculopathy

GO Terms for Toxic Maculopathy

Sources for Toxic Maculopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....