MCID: TXC001
MIFTS: 37

Toxic Megacolon

Categories: Gastrointestinal diseases

Aliases & Classifications for Toxic Megacolon

MalaCards integrated aliases for Toxic Megacolon:

Name: Toxic Megacolon 12 15
Megacolon, Toxic 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1770
MeSH 44 D008532
SNOMED-CT 67 28536002
ICD10 32 K59.31
UMLS 70 C0025162

Summaries for Toxic Megacolon

MalaCards based summary : Toxic Megacolon, also known as megacolon, toxic, is related to crohn's disease and gastroenteritis. An important gene associated with Toxic Megacolon is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Sertoli-Sertoli Cell Junction Dynamics and Signaling by Rho GTPases. The drugs Metronidazole and Vancomycin have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and spinal cord.

Wikipedia : 73 Toxic megacolon is an acute form of colonic distension. It is characterized by a very dilated colon... more...

Related Diseases for Toxic Megacolon

Diseases related to Toxic Megacolon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 433)
# Related Disease Score Top Affiliating Genes
1 crohn's disease 30.8 TNF CRP CCR6 ALB
2 gastroenteritis 30.6 TNF CRP ALB
3 peritonitis 30.5 TNF CRP ALB
4 paralytic ileus 30.5 CRP ATP4A ATP12A ALB
5 clostridium difficile colitis 30.5 RHOD RHOBTB1 CRP CCR6 ATP4A ATP12A
6 salmonellosis 30.4 TNF CCR6 ALB
7 compartment syndrome 30.4 TNF CRP ALB
8 typhoid fever 30.3 TNF CRP CCR6 ALB
9 acquired immunodeficiency syndrome 30.1 TNF CRP CCR6 ALB
10 volvulus of midgut 30.1 CRP ATP4A ATP12A ALB
11 microscopic colitis 30.0 TNF ATP4A ATP12A
12 proctitis 30.0 TNF CRP CCR6
13 disease by infectious agent 29.9 TNF CRP CCR6 ALB
14 cholangitis 29.9 TNF CRP ALB
15 endophthalmitis 29.9 TNF CRP ALB
16 intestinal perforation 29.9 TNF CRP ATP4A ATP12A ALB
17 constipation 29.9 TNF CRP ATP4A ATP12A ALB
18 dysentery 29.8 TNF CRP CCR6 ATP4A ATP12A ALB
19 cellulitis 29.8 TNF CRP CCR6 ALB
20 perinatal necrotizing enterocolitis 29.8 TNF CRP CCR6 ALB
21 cholangitis, primary sclerosing 29.8 TNF CRP CCR6 ALB
22 respiratory failure 29.7 TNF CRP CCR6 ALB
23 diverticulitis 29.6 TNF CRP CCR6 ATP4A ATP12A ALB
24 ulcerative colitis 11.3
25 megacolon 11.2
26 colitis 10.9
27 diarrhea 10.5
28 enterocolitis 10.5
29 crohn's colitis 10.5
30 inflammatory bowel disease 10.4
31 ischemic colitis 10.4
32 vagus nerve disease 10.4 ATP4A ATP12A
33 scalp dermatosis 10.4 ATP4A ATP12A
34 hemangioma of intra-abdominal structure 10.4 ATP4A ATP12A
35 acquired gastric outlet stenosis 10.4 ATP4A ATP12A
36 lingual goiter 10.4 ATP4A ATP12A
37 displacement of cardia through esophageal hiatus 10.4 ATP4A ATP12A
38 bacterial esophagitis 10.4 ATP4A ATP12A
39 cascade stomach 10.4 ATP4A ATP12A
40 benzylpenicillin allergy 10.4 ATP4A ATP12A
41 cervix erosion 10.4 ATP4A ATP12A
42 angiodysplasia of intestine 10.4 ATP4A ATP12A
43 granulomatous gastritis 10.4 ATP4A ATP12A
44 laryngeal tuberculosis 10.4 ATP4A ATP12A
45 fungal esophagitis 10.4 ATP4A ATP12A
46 dieulafoy lesion 10.4 ATP4A ATP12A
47 esophagus melanoma 10.4 ATP4A ATP12A
48 cefuroxime allergy 10.4 ATP4A ATP12A
49 gastric gastrinoma 10.4 ATP4A ATP12A
50 pneumatosis cystoides intestinalis 10.4 ATP4A ATP12A

Graphical network of the top 20 diseases related to Toxic Megacolon:



Diseases related to Toxic Megacolon

Symptoms & Phenotypes for Toxic Megacolon

Drugs & Therapeutics for Toxic Megacolon

Drugs for Toxic Megacolon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
2
Vancomycin Approved Phase 2, Phase 3 1404-90-6 441141 14969
3 Gastrointestinal Agents Phase 2, Phase 3
4 Cathartics Phase 2, Phase 3
5 Antiparasitic Agents Phase 2, Phase 3
6 Anti-Bacterial Agents Phase 2, Phase 3
7 Antibiotics, Antitubercular Phase 2, Phase 3
8 Antitubercular Agents Phase 2, Phase 3
9 Antiprotozoal Agents Phase 2, Phase 3
10 Anti-Infective Agents Phase 2, Phase 3
11 Polyethylene glycol 3350 Phase 2, Phase 3
12 Laxatives Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Feasibility Randomized Trial of Intestinal Lavage for the Treatment of Severe C. Difficile Infections Unknown status NCT02466698 Phase 2, Phase 3 Vancomycin;PEG;Metronidazole

Search NIH Clinical Center for Toxic Megacolon

Cochrane evidence based reviews: megacolon, toxic

Genetic Tests for Toxic Megacolon

Anatomical Context for Toxic Megacolon

MalaCards organs/tissues related to Toxic Megacolon:

40
Colon, Liver, Spinal Cord, Skin, Myeloid, Bone, Heart

Publications for Toxic Megacolon

Articles related to Toxic Megacolon:

(show top 50) (show all 835)
# Title Authors PMID Year
1
Medical therapy versus surgery in moderate-to-severe ulcerative colitis. 61
33051163 2021
2
Ustekinumab treatment for toxic megacolon in severe colonic Crohn's disease. 61
33244975 2021
3
Transgenic plants expressing a Clostridium difficile spore antigen as an approach to develop low-cost oral vaccines. 61
33666366 2021
4
The prognostic value of toxin B and binary toxin in Clostridioides difficile infection. 61
33660568 2021
5
Clostridium difficile: Diagnosis and the Consequence of Over Diagnosis. 61
33770398 2021
6
Acetylcholinesterase staining for the pathological diagnosis of Hirschsprung's disease. 61
32577882 2021
7
Colonisation Factor CD0873, an Attractive Oral Vaccine Candidate against Clostridioides difficile. 61
33540694 2021
8
Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota. 61
33469019 2021
9
Approach to the patient with infectious colitis: clinical features, work-up and treatment. 61
33105253 2021
10
Salmonella colitis with perforation in the absence of toxic megacolon. 61
32526078 2021
11
Toxic Clostridioides (formerly Clostridium) difficile colitis: No longer a diarrhea associated infection. 61
32680621 2021
12
Toxic megacolon due to Salmonella acute infectious colitis requiring total colectomy following loop ileostomy closure. 61
32396679 2020
13
Evaluation and management of the surgical abdomen. 61
33060375 2020
14
Increasing newly diagnosed inflammatory bowel disease and improving prognosis in China: a 30-year retrospective study from a single centre. 61
33183228 2020
15
CT features of toxic megacolon: A systematic review. 61
33189537 2020
16
The mechanisms and safety of probiotics against toxigenic clostridium difficile. 61
32520637 2020
17
Improving Appropriate Diagnosis of Clostridioides difficile Infection Through an Enteric Pathogen Order Set With Computerized Clinical Decision Support: An Interrupted Time Series Analysis. 61
33094113 2020
18
Microbiota in Clostridioides difficile-Associated Diarrhea: Comparison in Recurrent and Non-Recurrent Infections. 61
32911854 2020
19
Postoperative Pain Management in Patients With Ulcerative Colitis. 61
32992337 2020
20
A case with cytomegalovirus colitis and toxic megacolon initially diagnosed as Crohn's disease. 61
31973935 2020
21
[Non-severe Clostridioides difficile Infection: Are the data adequate to give up metronidazole?] 61
32785914 2020
22
Highly antimicrobial-resistant Nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan. 61
32340872 2020
23
Severe Clostridium difficile infections in intensive care units: Diverse clinical presentations. 61
32826190 2020
24
Early Colectomy Saves Lives in Toxic Megacolon Due to Clostridium difficile Infection. 61
32617595 2020
25
Growing consumption of antibiotics and epidemiology of Clostridioides difficile infections in Poland: A need to develop new solutions. 61
31813263 2020
26
From Nursery to Nursing Home: Emerging Concepts in Clostridioides difficile Pathogenesis. 61
32122939 2020
27
Harmful Algal Bloom Toxicity in Lithobates catesbeiana Tadpoles. 61
32521650 2020
28
Constipation screening in people taking clozapine: A diagnostic accuracy study. 61
32245597 2020
29
Systematic Review: Clinical Utility of Gastrointestinal Ultrasound in the Diagnosis, Assessment and Management of Patients With Ulcerative Colitis. 61
31562739 2020
30
The Clinical Drug Ebselen Attenuates Inflammation and Promotes Microbiome Recovery in Mice after Antibiotic Treatment for CDI. 61
32483557 2020
31
Updated Management Guidelines for Clostridioides difficile in Paediatrics. 61
32316346 2020
32
Clostridioides difficile Spores: Bile Acid Sensors and Trojan Horses of Transmission. 61
32104157 2020
33
Current Diagnostic and Therapeutic Approaches to Cytomegalovirus Infections in Ulcerative Colitis Patients Based on Clinical and Basic Research Data. 61
32244555 2020
34
Campylobactercolitis leads to toxic megacolon and multiple organ failure. 61
32205380 2020
35
Microbe-microbe interactions during Clostridioides difficile infection. 61
32088581 2020
36
Clostridioides difficile Infection: Update on Management. 61
32003951 2020
37
The Management of the Hospitalized Ulcerative Colitis Patient: the Medical-Surgical Conundrum. 61
32040642 2020
38
Cytomegalovirus ileo-pancolitis presenting as toxic megacolon in an immunocompetent patient: A case report. 61
32110666 2020
39
Toxic Megacolon: Background, Pathophysiology, Management Challenges and Solutions. 61
32547151 2020
40
[Three cases of severe and fulminating ulcerative colitis with megacolon treated with continuous intravenous infusion of cyclosporine]. 61
32037361 2020
41
Clostridioides difficile infection in the Asia-Pacific region. 61
31873046 2020
42
Fecal microbiota transplantation is feasible even in critically ill patients with toxic megacolon due to Clostridium difficile infection. 61
32200611 2020
43
Amoebic toxic megacolon with poly-helminthic coinfection: Case presentation and review of intestinal polyparasitic infections. 61
32450374 2020
44
Massive Hydrothorax and Ascites as the Primary Manifestation of Infection With Clostridium difficile: A Case Report and Literature Review. 61
32509714 2020
45
Biological characteristics associated with virulence in Clostridioides difficile ribotype 002 in Hong Kong. 61
32183606 2020
46
A Single-Center Experience and Literature Review of Management Strategies for Clostridium difficile Infection in Hematopoietic Stem Cell Transplant Patients. 61
33424210 2020
47
Dr. Orvar Swenson and the Pull-Through. 61
31912779 2019
48
A comprehensive review and update on ulcerative colitis. 61
30837080 2019
49
Metronidazole therapy as initial treatment of Clostridium difficile infection in patients with chronic kidney disease in Korea. 61
31607272 2019
50
An unusual case of caecal perforation following ileostomy reversal. 61
31473634 2019

Variations for Toxic Megacolon

Expression for Toxic Megacolon

Search GEO for disease gene expression data for Toxic Megacolon.

Pathways for Toxic Megacolon

GO Terms for Toxic Megacolon

Cellular components related to Toxic Megacolon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 9.8 RND2 RHOF RHOD RHOBTB2 RHOBTB1 RAC3
2 plasma membrane GO:0005886 9.77 TNF RND2 RHOV RHOU RHOJ RHOF
3 cytoplasmic vesicle GO:0031410 9.73 RND2 RHOF RHOD RHOBTB2 RHOBTB1 RAC3
4 cell projection GO:0042995 9.7 RND2 RHOU RHOF RHOD RHOBTB2 RHOBTB1
5 cell cortex GO:0005938 9.1 RND2 RHOF RHOD RHOBTB2 RHOBTB1 RAC3

Biological processes related to Toxic Megacolon according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell migration GO:0016477 9.93 RND2 RHOV RHOU RHOJ RHOF RHOD
2 actin filament organization GO:0007015 9.88 RND2 RHOF RHOD RHOBTB2 RHOBTB1 RAC3
3 regulation of cell shape GO:0008360 9.86 RND2 RHOU RHOJ RHOF RHOD RHOBTB2
4 regulation of actin cytoskeleton organization GO:0032956 9.85 RND2 RHOF RHOD RHOBTB2 RHOBTB1 RAC3
5 establishment or maintenance of cell polarity GO:0007163 9.8 RND2 RHOF RHOD RHOBTB2 RHOBTB1 RAC3
6 regulation of small GTPase mediated signal transduction GO:0051056 9.76 RHOV RHOU RHOJ RHOF RHOD RHOBTB2
7 cell projection assembly GO:0030031 9.73 RHOV RHOU RHOJ RAC3
8 Cdc42 protein signal transduction GO:0032488 9.65 RHOV RHOU RHOJ
9 engulfment of apoptotic cell GO:0043652 9.55 RHOBTB2 RHOBTB1
10 sodium ion export across plasma membrane GO:0036376 9.54 ATP4A ATP12A
11 cellular potassium ion homeostasis GO:0030007 9.52 ATP4A ATP12A
12 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.51 ATP4A ATP12A
13 negative regulation of lipid storage GO:0010888 9.49 TNF CRP
14 cortical cytoskeleton organization GO:0030865 9.43 RND2 RHOF RHOD RHOBTB2 RHOBTB1 RAC3
15 small GTPase mediated signal transduction GO:0007264 9.28 RND2 RHOV RHOU RHOJ RHOF RHOD

Molecular functions related to Toxic Megacolon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.9 RND2 RHOV RHOU RHOJ RHOF RHOD
2 protein kinase binding GO:0019901 9.73 RND2 RHOF RHOD RHOBTB2 RHOBTB1 RAC3
3 GTP binding GO:0005525 9.61 RND2 RHOV RHOU RHOJ RHOF RHOD
4 sodium:potassium-exchanging ATPase activity GO:0005391 9.4 ATP4A ATP12A
5 potassium-transporting ATPase activity GO:0008556 9.37 ATP4A ATP12A
6 potassium:proton exchanging ATPase activity GO:0008900 9.32 ATP4A ATP12A
7 GTPase activity GO:0003924 9.28 RND2 RHOV RHOU RHOJ RHOF RHOD

Sources for Toxic Megacolon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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