MCID: TXC001
MIFTS: 34

Toxic Megacolon

Categories: Gastrointestinal diseases

Aliases & Classifications for Toxic Megacolon

MalaCards integrated aliases for Toxic Megacolon:

Name: Toxic Megacolon 12 15
Megacolon, Toxic 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1770
MeSH 45 D008532
SNOMED-CT 69 28536002
ICD10 34 K59.31
UMLS 74 C0025162

Summaries for Toxic Megacolon

MalaCards based summary : Toxic Megacolon, also known as megacolon, toxic, is related to clostridium difficile colitis and megacolon. An important gene associated with Toxic Megacolon is PIGG (Phosphatidylinositol Glycan Anchor Biosynthesis Class G). The drugs Vancomycin and Fidaxomicin have been mentioned in the context of this disorder. Affiliated tissues include colon, spinal cord and bone marrow.

Wikipedia : 77 Toxic megacolon is an acute form of colonic distension. It is characterized by a very dilated colon... more...

Related Diseases for Toxic Megacolon

Diseases related to Toxic Megacolon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 clostridium difficile colitis 30.8 ATP12A ATP4A
2 megacolon 11.1
3 colitis 10.9
4 ulcerative colitis 10.7
5 crohn's disease 10.4
6 enterocolitis 10.2
7 inflammatory bowel disease 10.2
8 cytomegalovirus infection 10.2
9 crohn's colitis 10.2
10 diarrhea 10.1
11 typhoid fever 10.1
12 drug allergy 10.1 ALB ATP12A
13 fungal esophagitis 10.1 ATP12A ATP4A
14 diclofenac allergy 10.1 ATP12A ATP4A
15 gastroduodenal crohn's disease 10.1 ATP12A ATP4A
16 neonatal candidiasis 10.1 ATP12A ATP4A
17 photoallergic dermatitis 10.1 ATP12A ATP4A
18 squamous papillomatosis 10.0 ATP12A ATP4A
19 aspiration pneumonitis 10.0 ATP12A ATP4A
20 hirschsprung disease 1 10.0
21 leukemia 10.0
22 ischemic colitis 10.0
23 collagenous colitis 10.0
24 thrombosis 10.0
25 disseminated intravascular coagulation 10.0
26 shigellosis 10.0
27 gastroenteritis 10.0
28 compartment syndrome 10.0
29 amyloidosis 10.0
30 gastrointestinal neuroendocrine benign tumor 10.0 ATP12A ATP4A
31 gastric antral vascular ectasia 10.0 ATP12A ATP4A
32 granulomatous gastritis 10.0 ATP12A ATP4A
33 esophageal candidiasis 10.0 ATP12A ATP4A
34 gastric neuroendocrine neoplasm 10.0 ATP12A ATP4A
35 acute laryngitis 10.0 ATP12A ATP4A
36 laryngitis 10.0 ATP12A ATP4A
37 duodenitis 10.0 ATP12A ATP4A
38 rumination disorder 10.0 ATP12A ATP4A
39 active peptic ulcer disease 10.0 ATP12A ATP4A
40 congenital disorder of deglycosylation 10.0 ATP12A ATP4A
41 bladder calculus 10.0 ATP12A ATP4A
42 ischemic neuropathy 10.0 ATP12A ATP4A
43 bile reflux 10.0 ATP12A ATP4A
44 peptic esophagitis 10.0 ATP12A ATP4A
45 dyskinesia of esophagus 10.0 ATP12A ATP4A
46 hernia, hiatus 10.0 ATP12A ATP4A
47 anismus 10.0 ATP12A ATP4A
48 postsurgical hypothyroidism 10.0 ATP12A ATP4A
49 lymphocytic colitis 10.0 ATP12A ATP4A
50 esophageal atresia/tracheoesophageal fistula 10.0 ATP12A ATP4A

Graphical network of the top 20 diseases related to Toxic Megacolon:



Diseases related to Toxic Megacolon

Symptoms & Phenotypes for Toxic Megacolon

Drugs & Therapeutics for Toxic Megacolon

Drugs for Toxic Megacolon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vancomycin Approved Phase 4,Phase 2,Phase 3,Not Applicable 1404-90-6 14969 441141
2
Fidaxomicin Approved Phase 4 873857-62-6
3 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
4 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Not Applicable
5
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
6
Pantoprazole Approved Phase 3 102625-70-7 4679
7 Antibiotics, Antitubercular Phase 2, Phase 3,Not Applicable
8 Antitubercular Agents Phase 2, Phase 3,Not Applicable
9 Antiparasitic Agents Phase 2, Phase 3
10 Cathartics Phase 2, Phase 3
11 Antiprotozoal Agents Phase 2, Phase 3
12 Polyethylene glycol 3350 Phase 2, Phase 3
13 Laxatives Phase 2, Phase 3
14 Gastrointestinal Agents Phase 2, Phase 3,Phase 3
15 Antacids Phase 3
16 Proton Pump Inhibitors Phase 3
17 Anti-Ulcer Agents Phase 3
18
Cefazolin Approved Not Applicable 25953-19-9 33255 656510
19 Antibodies Not Applicable
20 Immunoglobulins Not Applicable
21 penicillins Not Applicable
22 Cephalosporins Not Applicable
23 Cola

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimal Treatment for Recurrent Clostridium Difficile Recruiting NCT02667418 Phase 4 Fidaxomicin;Vancomycin with Taper/Pulse;Vancomycin
2 Intestinal Lavage for the Treatment of Severe C. Difficile Infections Recruiting NCT02466698 Phase 2, Phase 3 Vancomycin;PEG;Metronidazole
3 Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial Not yet recruiting NCT03374800 Phase 3 Placebo (0.9% saline);Pantoprazole
4 Host Immune Response to Clostridium Difficile Infection (ICD) Completed NCT02440438 Not Applicable
5 Efficacy of Post-operative Antibiotic Prophylaxis for Thoracic Surgery Requiring Tube Thoracostomy Completed NCT00818766 Not Applicable cefazolin or vancomycin;Placebo
6 Observational Study of C. Diff in Post-Transplant Patients Completed NCT02747017
7 Genetic Mosaicism in Hirschsprung's Disease Recruiting NCT01927809
8 A Multicenter Prospective Cohort Study on the Clinical Prognosis of Ulcerative Colitis Recruiting NCT03698812
9 Oligosaccharide for Cdiff(+) Heme-onc Patients Not yet recruiting NCT03778606 Not Applicable
10 Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated Colitis Terminated NCT01959048 Not Applicable fecal microbiota transplantation

Search NIH Clinical Center for Toxic Megacolon

Cochrane evidence based reviews: megacolon, toxic

Genetic Tests for Toxic Megacolon

Anatomical Context for Toxic Megacolon

MalaCards organs/tissues related to Toxic Megacolon:

42
Colon, Spinal Cord, Bone Marrow, Myeloid, Smooth Muscle, Skin

Publications for Toxic Megacolon

Articles related to Toxic Megacolon:

(show top 50) (show all 259)
# Title Authors Year
1
Clostridioides difficile-related toxic megacolon after Cryptococcus neoformans cellulitis: A complex of two rare infections in an immunocompromised host. ( 30797689 )
2019
2
New-onset ulcerative colitis in pregnancy associated to toxic megacolon and sudden fetal decompensation: Case report and literature review. ( 31064034 )
2019
3
Shigellosis and toxic megacolon secondary to Shigella flexneri serotype 3a: The challenges of laboratory diagnosis. ( 29501836 )
2018
4
Incidence, features, in-hospital outcomes and predictors of in-hospital mortality associated with toxic megacolon hospitalizations in the United States. ( 29948833 )
2018
5
In-hospital mortality for toxic megacolon. ( 30073474 )
2018
6
First reported case of afatinib-associated toxic megacolon. ( 30186606 )
2018
7
Imaging features of toxic megacolon. ( 30275028 )
2018
8
Diagnosis and Treatment of Invasive Aspergillus fumigatus Wound Infection Following Subtotal Colectomy for Perforated Toxic Megacolon in an Immunosuppressed Patient. ( 30312971 )
2018
9
Toxic megacolon as a rare complication following atropine therapy due to organophosphate poisoning: A case report. ( 28403672 )
2017
10
Toxic Megacolon - A Three Case Presentation. ( 29967870 )
2017
11
Fecal Transplant for Treatment of Toxic Megacolon Associated With Clostridium Difficile Colitis in a Patient With Duchenne Muscular Dystrophy. ( 24858336 )
2016
12
Toxic megacolon and interstitial pneumonia caused by cytomegalovirus infection in a pediatric patient with acute lymphoblastic leukemia receiving chemotherapy. ( 28090493 )
2016
13
Induction of potentially lethal hypermagnesemia, ischemic colitis, and toxic megacolon by a preoperative mechanical bowel preparation: report of a case. ( 26943694 )
2016
14
Fatal Toxic Megacolon in a Child of Hirschsprung Disease. ( 28208866 )
2016
15
The Surgical Treatment of Toxic Megacolon in Hirschsprung Disease. ( 26181500 )
2016
16
Toxic Megacolon: A Review for Emergency Department Clinicians. ( 27185628 )
2016
17
Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality. ( 27281569 )
2016
18
Campylobacter colitis: Rare cause of toxic megacolon. ( 27614338 )
2016
19
Blowhole Colostomy for Clostridium difficile-Associated Toxic Megacolon. ( 28097034 )
2016
20
Fecal Microbiota Transplant for Clostridium difficile Colitis-Induced Toxic Megacolon. ( 25942309 )
2015
21
A case of toxic megacolon caused by clostridium difficile infection and treated with fecal microbiota transplantation. ( 25721003 )
2015
22
Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients. ( 25866348 )
2015
23
Toxic megacolon during pregnancy in ulcerative colitis: A case report. ( 25942749 )
2015
24
Toxic colonoscopy--how investigating active inflammatory bowel disease can lead to the serious complication of toxic megacolon. ( 26202312 )
2015
25
Unusual complication of toxic megacolon in typhoid colitis. ( 23900751 )
2014
26
Toxic megacolon after abdominoplasty: a case report. ( 24667886 )
2014
27
Toxic megacolon in ulcerative rectocolitis. Current trends in clinical evaluation, diagnosis and treatment. ( 24755987 )
2014
28
Surgical Management of Toxic Megacolon. ( 26176049 )
2014
29
Nonresectional surgical approach to toxic megacolon with abdominal compartment syndrome. ( 24351341 )
2013
30
Toxic Megacolon and Acute Ischemia of the Colon due to Sigmoid Stenosis Related to Diverticulitis. ( 24163654 )
2013
31
From impending toxic megacolon to multiple organ failure in severe ulcerative colitis. ( 22923362 )
2013
32
Toxic megacolon complicating a first course of Crohn's disease: about two cases. ( 24765512 )
2013
33
Toxic megacolon associated with cytomegalovirus infection in a patient with steroid-naïve ulcerative colitis. ( 23037465 )
2012
34
Fulminant Clostridium difficile toxic megacolon in a pediatric heart transplant recipient. ( 20887401 )
2012
35
Toxic megacolon from sexually transmitted Shigella sonnei infection. ( 21538050 )
2012
36
Infliximab in Crohn's disease-associated toxic megacolon. ( 21857531 )
2012
37
Toxic megacolon. ( 22009735 )
2012
38
"Ulcerative crepitus" -- a case with subcutaneous emphysema and pneumomediastinum without colonic perforation or toxic megacolon in ulcerative colitis successfully treated conservatively. ( 22398071 )
2012
39
Conservative surgical treatment for toxic megacolon due to Clostridium difficile infection in a transplanted pediatric patient. ( 22726419 )
2012
40
Impending megacolon: small bowel distension as a predictor of toxic megacolon in ulcerative colitis. ( 22843318 )
2012
41
Toxic megacolon from fulminant Clostridium difficile infection induced by topical silver sulphadiazine. ( 22878997 )
2012
42
Surgical outcome of community-acquired Clostridium difficile colitis presenting as toxic megacolon: case report. ( 21859335 )
2011
43
Toxic megacolon due to fulminant Clostridium Difficile colitis. ( 21861326 )
2011
44
Toxic megacolon with abdominal compartment syndrome. ( 21825926 )
2011
45
Toxic megacolon in patients with severe acute colitis: computed tomographic features. ( 22040786 )
2011
46
Toxic megacolon associated Clostridium difficile colitis. ( 21160629 )
2010
47
Toxic megacolon secondary to Clostridium difficile colitis. Case report. ( 20423791 )
2010
48
Cytomegalovirus infection in patients who required colectomy for toxic megacolon or severe steroid-refractory ulcerative colitis. ( 20094780 )
2010
49
Toxic megacolon complicating a Clostridium difficile infection in a pregnant woman. ( 19745034 )
2010
50
Colonic stricture and fistula following haemolytic uraemic syndrome with toxic megacolon. ( 19899041 )
2010

Variations for Toxic Megacolon

Expression for Toxic Megacolon

Search GEO for disease gene expression data for Toxic Megacolon.

Pathways for Toxic Megacolon

GO Terms for Toxic Megacolon

Biological processes related to Toxic Megacolon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.58 ATP12A ATP4A TMC1
2 potassium ion import across plasma membrane GO:1990573 9.37 ATP12A ATP4A
3 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
4 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
6 cellular potassium ion homeostasis GO:0030007 8.96 ATP12A ATP4A
7 sodium ion export across plasma membrane GO:0036376 8.62 ATP12A ATP4A

Molecular functions related to Toxic Megacolon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Toxic Megacolon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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