MCID: TXC001
MIFTS: 36

Toxic Megacolon

Categories: Gastrointestinal diseases

Aliases & Classifications for Toxic Megacolon

MalaCards integrated aliases for Toxic Megacolon:

Name: Toxic Megacolon 12 15
Megacolon, Toxic 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1770
ICD10 33 K59.31
MeSH 44 D008532
SNOMED-CT 68 28536002
UMLS 73 C0025162

Summaries for Toxic Megacolon

MalaCards based summary : Toxic Megacolon, also known as megacolon, toxic, is related to clostridium difficile colitis and megacolon. An important gene associated with Toxic Megacolon is PIGG (Phosphatidylinositol Glycan Anchor Biosynthesis Class G). The drugs Vancomycin and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and heart.

Wikipedia : 76 Toxic megacolon (megacolon toxicum) is an acute form of colonic distension. It is characterized by a... more...

Related Diseases for Toxic Megacolon

Diseases related to Toxic Megacolon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 clostridium difficile colitis 32.2 ATP12A ATP4A
2 megacolon 11.1
3 colitis 10.8
4 ulcerative colitis 10.7
5 crohn's disease 10.4
6 enterocolitis 10.2
7 cytomegalovirus infection 10.2
8 inflammatory bowel disease 10.2
9 crohn's colitis 10.1
10 diarrhea 10.1
11 hirschsprung disease 1 10.0
12 leukemia 10.0
13 ischemic colitis 10.0
14 collagenous colitis 10.0
15 thrombosis 10.0
16 disseminated intravascular coagulation 10.0
17 shigellosis 10.0
18 gastroenteritis 10.0
19 compartment syndrome 10.0
20 amyloidosis 10.0
21 fungal esophagitis 10.0 ATP12A ATP4A
22 diclofenac allergy 10.0 ATP12A ATP4A
23 gastroduodenal crohn's disease 10.0 ATP12A ATP4A
24 neonatal candidiasis 10.0 ATP12A ATP4A
25 photoallergic dermatitis 10.0 ATP12A ATP4A
26 squamous papillomatosis 10.0 ATP12A ATP4A
27 aspiration pneumonitis 10.0 ATP12A ATP4A
28 gastrointestinal neuroendocrine benign tumor 10.0 ATP12A ATP4A
29 gastric antral vascular ectasia 10.0 ATP12A ATP4A
30 granulomatous gastritis 10.0 ATP12A ATP4A
31 esophageal candidiasis 10.0 ATP12A ATP4A
32 gastric neuroendocrine neoplasm 10.0 ATP12A ATP4A
33 acute laryngitis 10.0 ATP12A ATP4A
34 laryngitis 10.0 ATP12A ATP4A
35 duodenitis 10.0 ATP12A ATP4A
36 rumination disorder 10.0 ATP12A ATP4A
37 active peptic ulcer disease 10.0 ATP12A ATP4A
38 congenital disorder of deglycosylation 10.0 ATP12A ATP4A
39 bladder calculus 10.0 ATP12A ATP4A
40 ischemic neuropathy 10.0 ATP12A ATP4A
41 bile reflux 10.0 ATP12A ATP4A
42 capillary disease 10.0 ATP12A ATP4A
43 peptic esophagitis 10.0 ATP12A ATP4A
44 dyskinesia of esophagus 10.0 ATP12A ATP4A
45 hernia, hiatus 10.0 ATP12A ATP4A
46 anismus 9.9 ATP12A ATP4A
47 postsurgical hypothyroidism 9.9 ATP12A ATP4A
48 lymphocytic colitis 9.9 ATP12A ATP4A
49 esophageal atresia/tracheoesophageal fistula 9.9 ATP12A ATP4A
50 diarrhea 1, secretory chloride, congenital 9.9 ATP12A ATP4A

Graphical network of the top 20 diseases related to Toxic Megacolon:



Diseases related to Toxic Megacolon

Symptoms & Phenotypes for Toxic Megacolon

Drugs & Therapeutics for Toxic Megacolon

Drugs for Toxic Megacolon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vancomycin Approved Phase 4,Phase 2,Phase 3,Not Applicable 1404-90-6 14969 441141
2 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
3 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Not Applicable
4
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
5
Pantoprazole Approved Phase 3 102625-70-7 4679
6 Antibiotics, Antitubercular Phase 2, Phase 3,Not Applicable
7 Antitubercular Agents Phase 2, Phase 3,Not Applicable
8 Laxatives Phase 2, Phase 3
9 Antiparasitic Agents Phase 2, Phase 3
10 Antiprotozoal Agents Phase 2, Phase 3
11 Cathartics Phase 2, Phase 3
12 Polyethylene glycol 3350 Phase 2, Phase 3
13 Gastrointestinal Agents Phase 2, Phase 3,Phase 3
14 Antacids Phase 3
15 Anti-Ulcer Agents Phase 3
16 Proton Pump Inhibitors Phase 3
17
Cefazolin Approved Not Applicable 25953-19-9 656510 33255
18 Immunoglobulins Not Applicable
19 Antibodies Not Applicable
20 Cephalosporins Not Applicable
21 penicillins Not Applicable
22 Cola

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimal Treatment for Recurrent Clostridium Difficile Recruiting NCT02667418 Phase 4 Fidaxomicin;Vancomycin with Taper/Pulse;Vancomycin
2 Intestinal Lavage for the Treatment of Severe C. Difficile Infections Recruiting NCT02466698 Phase 2, Phase 3 Vancomycin;PEG;Metronidazole
3 Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial Not yet recruiting NCT03374800 Phase 3 Placebo (0.9% saline);Pantoprazole
4 Host Immune Response to Clostridium Difficile Infection (ICD) Completed NCT02440438 Not Applicable
5 Efficacy of Post-operative Antibiotic Prophylaxis for Thoracic Surgery Requiring Tube Thoracostomy Completed NCT00818766 Not Applicable cefazolin or vancomycin;Placebo
6 Observational Study of C. Diff in Post-Transplant Patients Completed NCT02747017
7 Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated Colitis Recruiting NCT01959048 Not Applicable fecal microbiota transplantation
8 Genetic Mosaicism in Hirschsprung's Disease Recruiting NCT01927809
9 A Multicenter Prospective Cohort Study on the Clinical Prognosis of Ulcerative Colitis Recruiting NCT03698812
10 Oligosaccharide for Cdiff(+) Heme-onc Patients Not yet recruiting NCT03778606 Not Applicable

Search NIH Clinical Center for Toxic Megacolon

Cochrane evidence based reviews: megacolon, toxic

Genetic Tests for Toxic Megacolon

Anatomical Context for Toxic Megacolon

MalaCards organs/tissues related to Toxic Megacolon:

41
Colon, Bone, Heart, Spinal Cord, Smooth Muscle, Bone Marrow, Skin

Publications for Toxic Megacolon

Articles related to Toxic Megacolon:

(show top 50) (show all 256)
# Title Authors Year
1
Shigellosis and toxic megacolon secondary to Shigella flexneri serotype 3a: The challenges of laboratory diagnosis. ( 29501836 )
2018
2
Incidence, features, in-hospital outcomes and predictors of in-hospital mortality associated with toxic megacolon hospitalizations in the United States. ( 29948833 )
2018
3
In-hospital mortality for toxic megacolon. ( 30073474 )
2018
4
First reported case of afatinib-associated toxic megacolon. ( 30186606 )
2018
5
Imaging features of toxic megacolon. ( 30275028 )
2018
6
Diagnosis and Treatment of Invasive Aspergillus fumigatus Wound Infection Following Subtotal Colectomy for Perforated Toxic Megacolon in an Immunosuppressed Patient. ( 30312971 )
2018
7
Toxic megacolon as a rare complication following atropine therapy due to organophosphate poisoning: A case report. ( 28403672 )
2017
8
Toxic Megacolon - A Three Case Presentation. ( 29967870 )
2017
9
Campylobacter colitis: Rare cause of toxic megacolon. ( 27614338 )
2016
10
Toxic Megacolon: A Review for Emergency Department Clinicians. ( 27185628 )
2016
11
Induction of potentially lethal hypermagnesemia, ischemic colitis, and toxic megacolon by a preoperative mechanical bowel preparation: report of a case. ( 26943694 )
2016
12
Toxic megacolon and interstitial pneumonia caused by cytomegalovirus infection in a pediatric patient with acute lymphoblastic leukemia receiving chemotherapy. ( 28090493 )
2016
13
Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality. ( 27281569 )
2016
14
Blowhole Colostomy for Clostridium difficile-Associated Toxic Megacolon. ( 28097034 )
2016
15
Fatal Toxic Megacolon in a Child of Hirschsprung Disease. ( 28208866 )
2016
16
Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients. ( 25866348 )
2015
17
The Surgical Treatment of Toxic Megacolon in Hirschsprung Disease. ( 26181500 )
2015
18
Fecal Microbiota Transplant for Clostridium difficile Colitis-Induced Toxic Megacolon. ( 25942309 )
2015
19
A case of toxic megacolon caused by clostridium difficile infection and treated with fecal microbiota transplantation. ( 25721003 )
2015
20
Toxic colonoscopy--how investigating active inflammatory bowel disease can lead to the serious complication of toxic megacolon. ( 26202312 )
2015
21
Toxic megacolon during pregnancy in ulcerative colitis: A case report. ( 25942749 )
2015
22
Toxic megacolon after abdominoplasty: a case report. ( 24667886 )
2014
23
Fecal Transplant for Treatment of Toxic Megacolon Associated With Clostridium Difficile Colitis in a Patient With Duchenne Muscular Dystrophy. ( 24858336 )
2014
24
Toxic megacolon in ulcerative rectocolitis. Current trends in clinical evaluation, diagnosis and treatment. ( 24755987 )
2014
25
Surgical Management of Toxic Megacolon. ( 26176049 )
2014
26
Unusual Complication of Toxic Megacolon in Typhoid Colitis. ( 23900751 )
2013
27
Toxic megacolon complicating a first course of Crohn's disease: about two cases. ( 24765512 )
2013
28
From impending toxic megacolon to multiple organ failure in severe ulcerative colitis. ( 22923362 )
2013
29
Nonresectional surgical approach to toxic megacolon with abdominal compartment syndrome. ( 24351341 )
2013
30
Toxic Megacolon and Acute Ischemia of the Colon due to Sigmoid Stenosis Related to Diverticulitis. ( 24163654 )
2013
31
"Ulcerative crepitus" -- a case with subcutaneous emphysema and pneumomediastinum without colonic perforation or toxic megacolon in ulcerative colitis successfully treated conservatively. ( 22398071 )
2012
32
Toxic megacolon from fulminant Clostridium difficile infection induced by topical silver sulphadiazine. ( 22878997 )
2012
33
Impending megacolon: small bowel distension as a predictor of toxic megacolon in ulcerative colitis. ( 22843318 )
2012
34
Toxic megacolon. ( 22009735 )
2012
35
Conservative surgical treatment for toxic megacolon due to Clostridium difficile infection in a transplanted pediatric patient. ( 22726419 )
2012
36
Fulminant Clostridium difficile toxic megacolon in a pediatric heart transplant recipient. ( 20887401 )
2012
37
Toxic megacolon from sexually transmitted Shigella sonnei infection. ( 21538050 )
2012
38
Toxic megacolon associated with cytomegalovirus infection in a patient with steroid-naA^ve ulcerative colitis. ( 23037465 )
2012
39
Infliximab in Crohn's disease-associated toxic megacolon. ( 21857531 )
2012
40
Surgical outcome of community-acquired Clostridium difficile colitis presenting as toxic megacolon: case report. ( 21859335 )
2011
41
Toxic megacolon with abdominal compartment syndrome. ( 21825926 )
2011
42
Toxic megacolon due to fulminant Clostridium Difficile colitis. ( 21861326 )
2011
43
Toxic megacolon in patients with severe acute colitis: computed tomographic features. ( 22040786 )
2011
44
Ulcerative colitis presenting as toxic megacolon. ( 21189707 )
2010
45
Cytomegalovirus infection in patients who required colectomy for toxic megacolon or severe steroid-refractory ulcerative colitis. ( 20094780 )
2010
46
Toxic megacolon from hypervirulent Clostridium difficile infection (ribotype 027) following elective total knee replacement: an emerging challenge in modern health care. ( 22242068 )
2010
47
Splenic rupture secondary to venous thrombosis in a patient with ulcerative colitis and toxic megacolon. ( 21457644 )
2010
48
Endoscopic findings of intestinal BehAset's disease complicated with toxic megacolon. ( 20556721 )
2010
49
Toxic megacolon complicating a Clostridium difficile infection in a pregnant woman. ( 19745034 )
2010
50
Management of acute colitis and toxic megacolon. ( 22131898 )
2010

Variations for Toxic Megacolon

Expression for Toxic Megacolon

Search GEO for disease gene expression data for Toxic Megacolon.

Pathways for Toxic Megacolon

GO Terms for Toxic Megacolon

Biological processes related to Toxic Megacolon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.63 ATP12A ATP4A TMC1
2 sodium ion transport GO:0006814 9.48 ATP12A ATP4A
3 potassium ion import across plasma membrane GO:1990573 9.43 ATP12A ATP4A
4 potassium ion import GO:0010107 9.4 ATP12A ATP4A
5 ATP hydrolysis coupled proton transport GO:0015991 9.37 ATP12A ATP4A
6 regulation of pH GO:0006885 9.32 ATP12A EDNRB
7 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
8 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
9 cellular potassium ion homeostasis GO:0030007 8.96 ATP12A ATP4A
10 sodium ion export across plasma membrane GO:0036376 8.62 ATP12A ATP4A

Molecular functions related to Toxic Megacolon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Toxic Megacolon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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