MCID: TXC001
MIFTS: 34

Toxic Megacolon

Categories: Gastrointestinal diseases

Aliases & Classifications for Toxic Megacolon

MalaCards integrated aliases for Toxic Megacolon:

Name: Toxic Megacolon 12 15
Megacolon, Toxic 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1770
ICD10 33 K59.3
MeSH 44 D008532
SNOMED-CT 68 28536002
UMLS 73 C0025162

Summaries for Toxic Megacolon

MalaCards based summary : Toxic Megacolon, also known as megacolon, toxic, is related to clostridium difficile colitis and megacolon. An important gene associated with Toxic Megacolon is PIGG (Phosphatidylinositol Glycan Anchor Biosynthesis Class G). The drugs Vancomycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, myeloid and smooth muscle.

Wikipedia : 76 Toxic megacolon (megacolon toxicum) is an acute form of colonic distension. It is characterized by a... more...

Related Diseases for Toxic Megacolon

Diseases related to Toxic Megacolon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 clostridium difficile colitis 30.0 ATP12A ATP4A
2 megacolon 10.9
3 colitis 10.7
4 ulcerative colitis 10.6
5 crohn's disease 10.3
6 enterocolitis 10.1
7 inflammatory bowel disease 10.1
8 cytomegalovirus infection 10.1
9 crohn's colitis 10.0
10 diarrhea 10.0
11 fungal esophagitis 9.9 ATP12A ATP4A
12 bladder calculus 9.9 ATP12A ATP4A
13 gastrointestinal neuroendocrine benign tumor 9.9 ATP12A ATP4A
14 neonatal candidiasis 9.9 ATP12A ATP4A
15 photoallergic dermatitis 9.9 ATP12A ATP4A
16 hirschsprung disease 1 9.9
17 leukemia 9.9
18 ischemic colitis 9.9
19 collagenous colitis 9.9
20 thrombosis 9.9
21 disseminated intravascular coagulation 9.9
22 shigellosis 9.9
23 gastroenteritis 9.9
24 compartment syndrome 9.9
25 amyloidosis 9.9
26 squamous papillomatosis 9.9 ATP12A ATP4A
27 acute laryngitis 9.9 ATP12A ATP4A
28 gastroduodenal crohn's disease 9.9 ATP12A ATP4A
29 gastric neuroendocrine neoplasm 9.9 ATP12A ATP4A
30 aspiration pneumonitis 9.9 ATP12A ATP4A
31 postsurgical hypothyroidism 9.9 ATP12A ATP4A
32 gastric antral vascular ectasia 9.9 ATP12A ATP4A
33 esophageal candidiasis 9.9 ATP12A ATP4A
34 duodenitis 9.9 ATP12A ATP4A
35 rumination disorder 9.9 ATP12A ATP4A
36 bile reflux 9.9 ATP12A ATP4A
37 granulomatous gastritis 9.9 ATP12A ATP4A
38 active peptic ulcer disease 9.9 ATP12A ATP4A
39 laryngeal disease 9.8 ATP12A ATP4A
40 ischemic neuropathy 9.8 ATP12A ATP4A
41 capillary disease 9.8 ATP12A ATP4A
42 peptic esophagitis 9.8 ATP12A ATP4A
43 duodenal disease 9.8 ATP12A ATP4A
44 dyskinesia of esophagus 9.8 ATP12A ATP4A
45 hernia, hiatus 9.8 ATP12A ATP4A
46 congenital disorder of deglycosylation 9.8 ATP12A ATP4A
47 anismus 9.8 ATP12A ATP4A
48 esophageal atresia/tracheoesophageal fistula 9.8 ATP12A ATP4A
49 laryngitis 9.8 ATP12A ATP4A
50 laryngeal tuberculosis 9.8 ATP12A ATP4A

Graphical network of the top 20 diseases related to Toxic Megacolon:



Diseases related to Toxic Megacolon

Symptoms & Phenotypes for Toxic Megacolon

Drugs & Therapeutics for Toxic Megacolon

Drugs for Toxic Megacolon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vancomycin Approved Phase 4,Phase 2,Phase 3,Not Applicable 1404-90-6 441141 14969
2 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Not Applicable
3 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
4
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
5
Pantoprazole Approved Phase 3 102625-70-7 4679
6 Antibiotics, Antitubercular Phase 2, Phase 3,Not Applicable
7 Antitubercular Agents Phase 2, Phase 3,Not Applicable
8 Antiparasitic Agents Phase 2, Phase 3
9 Antiprotozoal Agents Phase 2, Phase 3
10 Cathartics Phase 2, Phase 3
11 Gastrointestinal Agents Phase 2, Phase 3,Phase 3
12 Laxatives Phase 2, Phase 3
13 Polyethylene glycol 3350 Phase 2, Phase 3
14 Antacids Phase 3
15 Anti-Ulcer Agents Phase 3
16 Proton Pump Inhibitors Phase 3
17
Cefazolin Approved Not Applicable 25953-19-9 656510 33255
18 Antibodies Not Applicable
19 Immunoglobulins Not Applicable
20 Cephalosporins Not Applicable
21 penicillins Not Applicable
22 Cola Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimal Treatment for Recurrent Clostridium Difficile Recruiting NCT02667418 Phase 4 Fidaxomicin;Vancomycin with Taper/Pulse;Vancomycin
2 Intestinal Lavage for the Treatment of Severe C. Difficile Infections Recruiting NCT02466698 Phase 2, Phase 3 Vancomycin;PEG;Metronidazole
3 Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial Not yet recruiting NCT03374800 Phase 3 Placebo (0.9% saline);Pantoprazole
4 Host Immune Response to Clostridium Difficile Infection (ICD) Completed NCT02440438 Not Applicable
5 Efficacy of Post-operative Antibiotic Prophylaxis for Thoracic Surgery Requiring Tube Thoracostomy Completed NCT00818766 Not Applicable cefazolin or vancomycin;Placebo
6 Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated Colitis Recruiting NCT01959048 Not Applicable fecal microbiota transplantation
7 Genetic Mosaicism in Hirschsprung's Disease Recruiting NCT01927809
8 Observational Study of C. Diff in Post-Transplant Patients Recruiting NCT02747017

Search NIH Clinical Center for Toxic Megacolon

Cochrane evidence based reviews: megacolon, toxic

Genetic Tests for Toxic Megacolon

Anatomical Context for Toxic Megacolon

MalaCards organs/tissues related to Toxic Megacolon:

41
Colon, Myeloid, Smooth Muscle, Heart, Bone, Spinal Cord, Bone Marrow

Publications for Toxic Megacolon

Articles related to Toxic Megacolon:

(show top 50) (show all 246)
# Title Authors Year
1
Shigellosis and toxic megacolon secondary to Shigella flexneri serotype 3a: The challenges of laboratory diagnosis. ( 29501836 )
2018
2
Incidence, features, in-hospital outcomes and predictors of in-hospital mortality associated with toxic megacolon hospitalizations in the United States. ( 29948833 )
2018
3
Toxic megacolon as a rare complication following atropine therapy due to organophosphate poisoning: A case report. ( 28403672 )
2017
4
Toxic Megacolon - A Three Case Presentation. ( 29967870 )
2017
5
Campylobacter colitis: Rare cause of toxic megacolon. ( 27614338 )
2016
6
Toxic Megacolon: A Review for Emergency Department Clinicians. ( 27185628 )
2016
7
Induction of potentially lethal hypermagnesemia, ischemic colitis, and toxic megacolon by a preoperative mechanical bowel preparation: report of a case. ( 26943694 )
2016
8
Toxic megacolon and interstitial pneumonia caused by cytomegalovirus infection in a pediatric patient with acute lymphoblastic leukemia receiving chemotherapy. ( 28090493 )
2016
9
Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality. ( 27281569 )
2016
10
Blowhole Colostomy for Clostridium difficile-Associated Toxic Megacolon. ( 28097034 )
2016
11
Fatal Toxic Megacolon in a Child of Hirschsprung Disease. ( 28208866 )
2016
12
Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients. ( 25866348 )
2015
13
The Surgical Treatment of Toxic Megacolon in Hirschsprung Disease. ( 26181500 )
2015
14
Fecal Microbiota Transplant for Clostridium difficile Colitis-Induced Toxic Megacolon. ( 25942309 )
2015
15
A case of toxic megacolon caused by clostridium difficile infection and treated with fecal microbiota transplantation. ( 25721003 )
2015
16
Toxic colonoscopy--how investigating active inflammatory bowel disease can lead to the serious complication of toxic megacolon. ( 26202312 )
2015
17
Toxic megacolon during pregnancy in ulcerative colitis: A case report. ( 25942749 )
2015
18
Toxic megacolon after abdominoplasty: a case report. ( 24667886 )
2014
19
Fecal Transplant for Treatment of Toxic Megacolon Associated With Clostridium Difficile Colitis in a Patient With Duchenne Muscular Dystrophy. ( 24858336 )
2014
20
Toxic megacolon in ulcerative rectocolitis. Current trends in clinical evaluation, diagnosis and treatment. ( 24755987 )
2014
21
Surgical Management of Toxic Megacolon. ( 26176049 )
2014
22
Unusual Complication of Toxic Megacolon in Typhoid Colitis. ( 23900751 )
2013
23
Toxic megacolon complicating a first course of Crohn's disease: about two cases. ( 24765512 )
2013
24
From impending toxic megacolon to multiple organ failure in severe ulcerative colitis. ( 22923362 )
2013
25
Nonresectional surgical approach to toxic megacolon with abdominal compartment syndrome. ( 24351341 )
2013
26
Toxic Megacolon and Acute Ischemia of the Colon due to Sigmoid Stenosis Related to Diverticulitis. ( 24163654 )
2013
27
"Ulcerative crepitus" -- a case with subcutaneous emphysema and pneumomediastinum without colonic perforation or toxic megacolon in ulcerative colitis successfully treated conservatively. ( 22398071 )
2012
28
Toxic megacolon from fulminant Clostridium difficile infection induced by topical silver sulphadiazine. ( 22878997 )
2012
29
Impending megacolon: small bowel distension as a predictor of toxic megacolon in ulcerative colitis. ( 22843318 )
2012
30
Toxic megacolon. ( 22009735 )
2012
31
Conservative surgical treatment for toxic megacolon due to Clostridium difficile infection in a transplanted pediatric patient. ( 22726419 )
2012
32
Fulminant Clostridium difficile toxic megacolon in a pediatric heart transplant recipient. ( 20887401 )
2012
33
Toxic megacolon from sexually transmitted Shigella sonnei infection. ( 21538050 )
2012
34
Toxic megacolon associated with cytomegalovirus infection in a patient with steroid-naA^ve ulcerative colitis. ( 23037465 )
2012
35
Infliximab in Crohn's disease-associated toxic megacolon. ( 21857531 )
2012
36
Surgical outcome of community-acquired Clostridium difficile colitis presenting as toxic megacolon: case report. ( 21859335 )
2011
37
Toxic megacolon with abdominal compartment syndrome. ( 21825926 )
2011
38
Toxic megacolon due to fulminant Clostridium Difficile colitis. ( 21861326 )
2011
39
Toxic megacolon in patients with severe acute colitis: computed tomographic features. ( 22040786 )
2011
40
Ulcerative colitis presenting as toxic megacolon. ( 21189707 )
2010
41
Cytomegalovirus infection in patients who required colectomy for toxic megacolon or severe steroid-refractory ulcerative colitis. ( 20094780 )
2010
42
Toxic megacolon from hypervirulent Clostridium difficile infection (ribotype 027) following elective total knee replacement: an emerging challenge in modern health care. ( 22242068 )
2010
43
Splenic rupture secondary to venous thrombosis in a patient with ulcerative colitis and toxic megacolon. ( 21457644 )
2010
44
Endoscopic findings of intestinal BehAset's disease complicated with toxic megacolon. ( 20556721 )
2010
45
Toxic megacolon complicating a Clostridium difficile infection in a pregnant woman. ( 19745034 )
2010
46
Management of acute colitis and toxic megacolon. ( 22131898 )
2010
47
Colonic stricture and fistula following haemolytic uraemic syndrome with toxic megacolon. ( 19899041 )
2010
48
Toxic megacolon associated Clostridium difficile colitis. ( 21160629 )
2010
49
Toxic megacolon secondary to Clostridium difficile colitis. Case report. ( 20423791 )
2010
50
A case of toxic megacolon in a patient with collagenous colitis. ( 19484403 )
2009

Variations for Toxic Megacolon

Expression for Toxic Megacolon

Search GEO for disease gene expression data for Toxic Megacolon.

Pathways for Toxic Megacolon

GO Terms for Toxic Megacolon

Biological processes related to Toxic Megacolon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.61 ATP12A ATP4A TMC1
2 sodium ion transport GO:0006814 9.46 ATP12A ATP4A
3 potassium ion import GO:0010107 9.4 ATP12A ATP4A
4 ATP hydrolysis coupled proton transport GO:0015991 9.37 ATP12A ATP4A
5 regulation of pH GO:0006885 9.32 ATP12A EDNRB
6 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
7 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
8 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
9 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Toxic Megacolon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Toxic Megacolon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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