MCID: TXC010
MIFTS: 30

Toxic Myocarditis

Categories: Cardiovascular diseases

Aliases & Classifications for Toxic Myocarditis

MalaCards integrated aliases for Toxic Myocarditis:

Name: Toxic Myocarditis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9694
ICD9CM 36 422.93
SNOMED-CT 69 31993003
UMLS 74 C0155691

Summaries for Toxic Myocarditis

MalaCards based summary : Toxic Myocarditis is related to gas gangrene and acute myocardial infarction. An important gene associated with Toxic Myocarditis is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are Cellular Senescence (REACTOME) and Apoptosis Pathway. Affiliated tissues include kidney, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Toxic Myocarditis

Diseases related to Toxic Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 gas gangrene 30.1 PIK3C2A TNNI3
2 acute myocardial infarction 29.9 NPPB PIK3C2A TNNI3
3 myocardial infarction 29.2 NOS3 NPPB NPY PIK3C2A TNNI3
4 myocarditis 10.5
5 tick paralysis 10.4 PIK3C2A TNNI3
6 cardiogenic shock 10.3 NPPB PIK3C2A
7 inferior myocardial infarction 10.3 NPPB PIK3C2A
8 cryptogenic organizing pneumonia 10.3 CXCL8 PIK3C2A
9 left bundle branch hemiblock 10.2 NPPB TNNI3
10 pericardium disease 10.2 PIK3C2A TNNI3
11 status asthmaticus 10.2 CXCL8 PIK3C2A
12 acute anterolateral myocardial infarction 10.2 KANTR PIK3C2A
13 coronary artery vasospasm 10.2 NOS3 PIK3C2A
14 myocardial stunning 10.2 SOD1 TNNI3
15 central sleep apnea 10.2 NOS3 NPPB
16 coronary stenosis 10.2 NPPB PIK3C2A TNNI3
17 chronic mountain sickness 10.2 NOS3 NPPB
18 posterior myocardial infarction 10.2 KANTR PIK3C2A
19 anteroseptal myocardial infarction 10.2 KANTR PIK3C2A
20 postcholecystectomy syndrome 10.2 KANTR SOD1
21 leukoregulin 10.2 CXCL8 JUN
22 endocarditis 10.1 CXCL8 PIK3C2A TNNI3
23 intracranial vasospasm 10.1 KANTR NOS3
24 ischemic heart disease 10.1 NOS3 NPPB
25 angina pectoris 10.1 NOS3 NPPB PIK3C2A
26 intermediate coronary syndrome 10.1 PIK3C2A TNNI3
27 alveolar periostitis 10.0 JUN KANTR
28 diastolic heart failure 10.0 NOS3 NPPB
29 acute chest syndrome 10.0 CXCL8 NOS3
30 tinea favosa 10.0 MAPK8 NOS3
31 photokeratitis 10.0 JUN NOS3
32 sleep apnea 10.0 CXCL8 NOS3 NPPB
33 tetrahydrobiopterin deficiency 10.0 NOS3 SOD1
34 chronic kidney failure 10.0 NOS3 NPPB SOD1
35 diphtheria 9.9
36 paracetamol poisoning 9.9
37 coronary artery anomaly 9.9 NOS3 NPPB PIK3C2A TNNI3
38 pulmonary edema 9.9 CXCL8 NOS3 NPPB PIK3C2A
39 atrial standstill 1 9.8
40 hepatitis 9.8
41 colitis 9.8
42 common cold 9.8
43 interstitial nephritis 9.8
44 cutaneous diphtheria 9.8
45 peritonitis 9.8
46 arteries, anomalies of 9.8 KANTR NOS3 NPPB TNNI3
47 heart disease 9.7 CXCL8 NOS3 NPPB PIK3C2A TNNI3
48 drug-induced hearing loss 9.6 JUN MAPK8

Graphical network of the top 20 diseases related to Toxic Myocarditis:



Diseases related to Toxic Myocarditis

Symptoms & Phenotypes for Toxic Myocarditis

GenomeRNAi Phenotypes related to Toxic Myocarditis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.64 PIK3C2A
2 Decreased viability GR00221-A-1 9.64 MAPK8 PIK3C2A
3 Decreased viability GR00221-A-2 9.64 JUN MAPK8 PIK3C2A SOD1
4 Decreased viability GR00221-A-3 9.64 JUN SOD1
5 Decreased viability GR00221-A-4 9.64 PIK3C2A SOD1
6 Decreased viability GR00240-S-1 9.64 PIK3C2A
7 Decreased viability GR00342-S-1 9.64 PIK3C2A
8 Decreased viability GR00342-S-2 9.64 MAPK8 PIK3C2A
9 Decreased viability GR00342-S-3 9.64 MAPK8 PIK3C2A
10 Decreased viability GR00402-S-2 9.64 JUN MAPK8 PIK3C2A SOD1

MGI Mouse Phenotypes related to Toxic Myocarditis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 CYBB JUN MAPK8 NOS3 NPY SOD1
2 cardiovascular system MP:0005385 9.86 ATP11A CYBB JUN MAPK8 NOS3 PIK3C2A
3 adipose tissue MP:0005375 9.77 CYBB MAPK8 NOS3 NPY PIK3C2A
4 liver/biliary system MP:0005370 9.63 ATP11A JUN MAPK8 NOS3 NPY SOD1
5 muscle MP:0005369 9.43 ATP11A CYBB MAPK8 NOS3 SOD1 TNNI3
6 nervous system MP:0003631 9.17 ATP11A CYBB JUN MAPK8 NOS3 NPY

Drugs & Therapeutics for Toxic Myocarditis

Search Clinical Trials , NIH Clinical Center for Toxic Myocarditis

Genetic Tests for Toxic Myocarditis

Anatomical Context for Toxic Myocarditis

MalaCards organs/tissues related to Toxic Myocarditis:

42
Kidney

Publications for Toxic Myocarditis

Articles related to Toxic Myocarditis:

(show all 27)
# Title Authors Year
1
Marijuana Induced Myocarditis: A New Entity of Toxic Myocarditis. ( 30533519 )
2018
2
Chronic Marijuana and Synthetic Cannabinoid-Induced Toxic Myocarditis and End-Stage Cardiomyopathy: Management With Mechanical Circulatory Support as a Bridge-to-Transplantation. ( 30606509 )
2018
3
Toxic Myocarditis Caused by Acetaminophen in a Multidrug Overdose. ( 28795995 )
2017
4
Cardiac magnetic resonance study of scorpion toxic myocarditis. ( 28040703 )
2017
5
A Rare Case of Toxic Myocarditis Caused by Bacterial Liver Abscess Mimicking Acute Myocardial Infarction. ( 26726772 )
2016
6
Acute interstitial nephritis, toxic hepatitis and toxic myocarditis following multiple Asian giant hornet stings in Shaanxi Province, China. ( 26910407 )
2016
7
Evaluation of left ventricular function by bedside ultrasound in acute toxic myocarditis. ( 23849366 )
2013
8
Fulminant colitis and toxic myocarditis: a unifying cause? ( 20006131 )
2009
9
Intra-aortic balloon pump in toxic myocarditis due to aluminum phosphide poisoning. ( 19415593 )
2009
10
Brugada pattern in toxic myocarditis due to severe aluminum phosphide poisoning. ( 19712068 )
2009
11
Thoratec left ventricular assist device removal after toxic myocarditis. ( 19022028 )
2008
12
Toxic myocarditis due to oral ingestion of hydrofluoric acid. ( 17822953 )
2008
13
Drug-induced toxic myocarditis. ( 12638679 )
2003
14
Acute fatal toxic myocarditis after black widow spider envenomation. ( 12526131 )
2003
15
5-Fluorouracil related toxic myocarditis: case reports and pathological confirmation. ( 7954023 )
1994
16
Toxic myocarditis in paracetamol poisoning. ( 3122934 )
1988
17
Toxic myocarditis in paracetamol poisoning. ( 3120894 )
1987
18
Toxic myocarditis with resultant arrhythmias due to scorpion sting. ( 7320003 )
1981
19
Survival after major burn complicated by gas gangrene, acute renal failure, and toxic myocarditis. ( 435749 )
1979
20
Toxic myocarditis due to scorpion bite--a case report. ( 5835669 )
1965
21
Toxic myocarditis. Report of a case arising from ingestion of liquid plastic catalyst. ( 13886477 )
1962
22
Steroid treatment of infectious toxic myocarditis. ( 13762672 )
1960
23
A case of toxic myocarditis due to the common cold with an unusual type of electrocardiogram. ( 14393180 )
1955
24
Cutaneous diphtheria with toxic myocarditis; report of fatal case with necropsy findings. ( 20278466 )
1947
25
Primary streptococcic peritonitis with complicating toxic myocarditis and pulmonary emboli; a report of a case with eventual recovery. ( 18896519 )
1947
26
Toxic myocarditis. ( 20276781 )
1946
27
Diphtheria; toxic myocarditis; diphtheria with nephritis. ( 20982899 )
1946

Variations for Toxic Myocarditis

Expression for Toxic Myocarditis

Search GEO for disease gene expression data for Toxic Myocarditis.

Pathways for Toxic Myocarditis

Pathways related to Toxic Myocarditis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 CXCL8 CYBB JUN MAPK8 SOD1
2
Show member pathways
12.2 JUN MAPK8 NOS3 PIK3C2A
3
Show member pathways
12.11 CYBB JUN MAPK8
4
Show member pathways
12.1 CXCL8 CYBB JUN MAPK8 NOS3
5
Show member pathways
12.07 CXCL8 CYBB JUN MAPK8
6
Show member pathways
12.07 MAPK8 NOS3 PIK3C2A
7
Show member pathways
12.06 CXCL8 JUN MAPK8
8 12.03 JUN MAPK8 NPY TNNI3
9 12.01 JUN MAPK8 NOS3
10
Show member pathways
11.99 CXCL8 JUN MAPK8
11
Show member pathways
11.99 JUN MAPK8 PIK3C2A
12 11.92 JUN MAPK8 NOS3
13
Show member pathways
11.85 JUN MAPK8 NOS3
14
Show member pathways
11.85 JUN MAPK8 PIK3C2A
15 11.8 JUN MAPK8 PIK3C2A
16 11.69 CXCL8 MAPK8 NOS3
17 11.65 CXCL8 JUN MAPK8
18
Show member pathways
11.62 CXCL8 JUN MAPK8
19 11.6 CXCL8 JUN MAPK8
20 11.55 CXCL8 JUN MAPK8
21 11.47 JUN MAPK8 SOD1
22
Show member pathways
11.38 JUN MAPK8 NOS3 PIK3C2A
23 11.35 CXCL8 JUN MAPK8
24 11.25 CXCL8 JUN MAPK8
25 11.21 NOS3 NPY
26 11.19 CXCL8 MAPK8
27 11.14 JUN MAPK8
28 11.11 JUN MAPK8
29 11.1 JUN MAPK8
30 11.08 JUN MAPK8 NOS3 SOD1
31 11.07 JUN MAPK8
32 11.06 JUN MAPK8
33 11.03 JUN MAPK8
34 11.03 CXCL8 JUN NOS3
35 11.02 CXCL8 CYBB JUN MAPK8 NOS3
36 11.01 CXCL8 MAPK8
37 11 JUN MAPK8
38 10.67 JUN MAPK8

GO Terms for Toxic Myocarditis

Biological processes related to Toxic Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.61 CXCL8 CYBB NOS3
2 superoxide metabolic process GO:0006801 9.46 CYBB SOD1
3 regulation of blood vessel size GO:0050880 9.4 NOS3 NPPB
4 heart contraction GO:0060047 9.37 SOD1 TNNI3
5 removal of superoxide radicals GO:0019430 9.32 NOS3 SOD1
6 superoxide anion generation GO:0042554 9.26 CYBB SOD1
7 regulation of blood pressure GO:0008217 9.26 NOS3 NPPB NPY SOD1
8 hydrogen peroxide biosynthetic process GO:0050665 9.16 CYBB SOD1
9 cellular response to cadmium ion GO:0071276 8.92 CYBB JUN MAPK8 SOD1

Sources for Toxic Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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