MCID: TXC010
MIFTS: 30

Toxic Myocarditis

Categories: Cardiovascular diseases

Aliases & Classifications for Toxic Myocarditis

MalaCards integrated aliases for Toxic Myocarditis:

Name: Toxic Myocarditis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9694
ICD9CM 35 422.93
SNOMED-CT 68 31993003
UMLS 73 C0155691

Summaries for Toxic Myocarditis

MalaCards based summary : Toxic Myocarditis is related to gas gangrene and acute myocardial infarction. An important gene associated with Toxic Myocarditis is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are fMLP Pathway and Apoptosis Pathway. Affiliated tissues include liver, and related phenotypes are behavior/neurological and cardiovascular system

Related Diseases for Toxic Myocarditis

Diseases related to Toxic Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 gas gangrene 30.3 PIK3C2A TNNI3
2 acute myocardial infarction 29.9 NPPB PIK3C2A TNNI3
3 myocardial infarction 28.3 NOS3 NPPB NPY PIK3C2A TNNI3
4 tick paralysis 10.7 PIK3C2A TNNI3
5 cardiogenic shock 10.6 NPPB PIK3C2A
6 inferior myocardial infarction 10.6 NPPB PIK3C2A
7 cryptogenic organizing pneumonia 10.5 CXCL8 PIK3C2A
8 acute anterolateral myocardial infarction 10.4 KANTR PIK3C2A
9 status asthmaticus 10.4 CXCL8 PIK3C2A
10 thyroid crisis 10.4 KANTR ZIC3
11 leukoregulin 10.4 CXCL8 JUN
12 myocarditis 10.4
13 tricuspid valve insufficiency 10.3 NPPB ZIC3
14 posterior myocardial infarction 10.3 KANTR PIK3C2A
15 tricuspid valve disease 10.3 NPPB ZIC3
16 endocarditis 10.3 CXCL8 PIK3C2A TNNI3
17 anteroseptal myocardial infarction 10.3 KANTR PIK3C2A
18 central sleep apnea 10.3 NOS3 NPPB
19 chronic mountain sickness 10.2 NOS3 NPPB
20 extrinsic cardiomyopathy 10.1 KANTR PIK3C2A TNNI3
21 alveolar periostitis 10.1 JUN KANTR
22 intracranial vasospasm 10.1 KANTR NOS3
23 photokeratitis 10.0 JUN NOS3
24 acute chest syndrome 10.0 CXCL8 NOS3
25 tinea favosa 9.9 MAPK8 NOS3
26 intermediate coronary syndrome 9.9 PIK3C2A TNNI3
27 diastolic heart failure 9.9 NOS3 NPPB
28 sleep apnea 9.9 CXCL8 NOS3 NPPB
29 diphtheria 9.8
30 paracetamol poisoning 9.8
31 ischemic heart disease 9.8 NOS3 NPPB
32 coronary artery anomaly 9.7 NOS3 NPPB PIK3C2A TNNI3
33 burns 9.7
34 hepatitis 9.7
35 colitis 9.7
36 common cold 9.7
37 interstitial nephritis 9.7
38 cutaneous diphtheria 9.7
39 peritonitis 9.7
40 pulmonary edema 9.6 CXCL8 NOS3 NPPB PIK3C2A
41 arteries, anomalies of 9.4 KANTR NOS3 NPPB TNNI3
42 heart disease 9.4 NOS3 NPPB PIK3C2A TNNI3 ZIC3

Graphical network of the top 20 diseases related to Toxic Myocarditis:



Diseases related to Toxic Myocarditis

Symptoms & Phenotypes for Toxic Myocarditis

MGI Mouse Phenotypes related to Toxic Myocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.92 MAPK8 NOS3 NPY PIK3C2A TNNI3 CYBB
2 cardiovascular system MP:0005385 9.86 NOS3 PIK3C2A TNNI3 ATP11A ZIC3 CYBB
3 liver/biliary system MP:0005370 9.63 NOS3 NPY ATP11A ZIC3 JUN MAPK8
4 nervous system MP:0003631 9.56 MAPK8 NOS3 NPY PIK3C2A ATP11A CYBB
5 respiratory system MP:0005388 9.1 MAPK8 NOS3 TNNI3 ATP11A ZIC3 JUN

Drugs & Therapeutics for Toxic Myocarditis

Search Clinical Trials , NIH Clinical Center for Toxic Myocarditis

Genetic Tests for Toxic Myocarditis

Anatomical Context for Toxic Myocarditis

MalaCards organs/tissues related to Toxic Myocarditis:

41
Liver

Publications for Toxic Myocarditis

Articles related to Toxic Myocarditis:

(show all 25)
# Title Authors Year
1
Toxic Myocarditis Caused by Acetaminophen in a Multidrug Overdose. ( 28795995 )
2017
2
Acute interstitial nephritis, toxic hepatitis and toxic myocarditis following multiple Asian giant hornet stings in Shaanxi Province, China. ( 26910407 )
2016
3
A Rare Case of Toxic Myocarditis Caused by Bacterial Liver Abscess Mimicking Acute Myocardial Infarction. ( 26726772 )
2016
4
Cardiac magnetic resonance study of scorpion toxic myocarditis. ( 28040703 )
2016
5
Evaluation of left ventricular function by bedside ultrasound in acute toxic myocarditis. ( 23849366 )
2013
6
Fulminant colitis and toxic myocarditis: a unifying cause? ( 20006131 )
2009
7
Intra-aortic balloon pump in toxic myocarditis due to aluminum phosphide poisoning. ( 19415593 )
2009
8
Brugada pattern in toxic myocarditis due to severe aluminum phosphide poisoning. ( 19712068 )
2009
9
Toxic myocarditis due to oral ingestion of hydrofluoric acid. ( 17822953 )
2008
10
Thoratec left ventricular assist device removal after toxic myocarditis. ( 19022028 )
2008
11
Acute fatal toxic myocarditis after black widow spider envenomation. ( 12526131 )
2003
12
Drug-induced toxic myocarditis. ( 12638679 )
2003
13
5-Fluorouracil related toxic myocarditis: case reports and pathological confirmation. ( 7954023 )
1994
14
Toxic myocarditis in paracetamol poisoning. ( 3122934 )
1988
15
Toxic myocarditis in paracetamol poisoning. ( 3120894 )
1987
16
Toxic myocarditis with resultant arrhythmias due to scorpion sting. ( 7320003 )
1981
17
Survival after major burn complicated by gas gangrene, acute renal failure, and toxic myocarditis. ( 435749 )
1979
18
Toxic myocarditis due to scorpion bite--a case report. ( 5835669 )
1965
19
Toxic myocarditis. Report of a case arising from ingestion of liquid plastic catalyst. ( 13886477 )
1962
20
Steroid treatment of infectious toxic myocarditis. ( 13762672 )
1960
21
A case of toxic myocarditis due to the common cold with an unusual type of electrocardiogram. ( 14393180 )
1955
22
Primary streptococcic peritonitis with complicating toxic myocarditis and pulmonary emboli; a report of a case with eventual recovery. ( 18896519 )
1947
23
Cutaneous diphtheria with toxic myocarditis; report of fatal case with necropsy findings. ( 20278466 )
1947
24
Toxic myocarditis. ( 20276781 )
1946
25
Diphtheria; toxic myocarditis; diphtheria with nephritis. ( 20982899 )
1946

Variations for Toxic Myocarditis

Expression for Toxic Myocarditis

Search GEO for disease gene expression data for Toxic Myocarditis.

Pathways for Toxic Myocarditis

Pathways related to Toxic Myocarditis according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 JUN MAPK8 NOS3 PIK3C2A ZIC3
2
Show member pathways
12.18 JUN MAPK8 NOS3 PIK3C2A
3
Show member pathways
12.12 CYBB JUN MAPK8
4
Show member pathways
12.11 CXCL8 JUN MAPK8
5
Show member pathways
12.09 MAPK8 NOS3 PIK3C2A
6
Show member pathways
12.08 CXCL8 JUN MAPK8
7
Show member pathways
12.08 CYBB JUN MAPK8
8 12.01 JUN MAPK8 NOS3
9
Show member pathways
12 CXCL8 JUN MAPK8
10
Show member pathways
12 CXCL8 CYBB JUN MAPK8 NOS3
11
Show member pathways
11.99 JUN MAPK8 PIK3C2A
12
Show member pathways
11.97 JUN MAPK8 NPY TNNI3
13 11.92 JUN MAPK8 NOS3
14
Show member pathways
11.86 JUN MAPK8 NOS3
15
Show member pathways
11.85 JUN MAPK8 PIK3C2A
16 11.81 JUN MAPK8 PIK3C2A
17 11.69 CXCL8 MAPK8 NOS3
18
Show member pathways
11.68 CXCL8 CYBB JUN
19 11.63 CXCL8 JUN MAPK8
20
Show member pathways
11.61 CXCL8 JUN MAPK8
21 11.58 CXCL8 JUN MAPK8
22 11.53 CXCL8 JUN MAPK8
23 11.43 JUN MAPK8 NOS3
24 11.32 CXCL8 JUN MAPK8
25 11.21 NOS3 NPY
26 11.21 CXCL8 JUN MAPK8
27 11.19 CXCL8 MAPK8
28
Show member pathways
11.18 JUN MAPK8 NOS3 PIK3C2A
29 11.15 JUN MAPK8
30 11.11 JUN MAPK8
31 11.11 JUN MAPK8
32 11.07 JUN MAPK8
33 11.06 JUN MAPK8
34 11.04 JUN MAPK8
35 11.02 CXCL8 CYBB JUN MAPK8 NOS3
36 11.01 CXCL8 MAPK8
37 11.01 JUN MAPK8
38 10.96 CXCL8 JUN NOS3
39 10.68 JUN MAPK8

GO Terms for Toxic Myocarditis

Biological processes related to Toxic Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.54 CXCL8 JUN NOS3
2 positive regulation of angiogenesis GO:0045766 9.43 CXCL8 CYBB NOS3
3 regulation of DNA binding transcription factor activity GO:0051090 9.32 JUN MAPK8
4 regulation of blood vessel size GO:0050880 9.16 NOS3 NPPB
5 regulation of blood pressure GO:0008217 9.13 NOS3 NPPB NPY
6 cellular response to cadmium ion GO:0071276 8.8 CYBB JUN MAPK8

Sources for Toxic Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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