MCID: TXC010
MIFTS: 26

Toxic Myocarditis

Categories: Cardiovascular diseases

Aliases & Classifications for Toxic Myocarditis

MalaCards integrated aliases for Toxic Myocarditis:

Name: Toxic Myocarditis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9694
ICD9CM 34 422.93
SNOMED-CT 67 31993003
UMLS 71 C0155691

Summaries for Toxic Myocarditis

Disease Ontology : 12 An acute myocarditis that is characterized by an underlying toxin insult to the myocardium that induces acute inflammation.

MalaCards based summary : Toxic Myocarditis is related to myocarditis and cardiogenic shock. An important gene associated with Toxic Myocarditis is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha). The drugs Captopril and Antihypertensive Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, myeloid and heart.

Related Diseases for Toxic Myocarditis

Diseases related to Toxic Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 myocarditis 30.4 TNNI3 PIK3C2A NPPB ACE
2 cardiogenic shock 30.3 PIK3C2A NPPB
3 gas gangrene 30.1 TNNI3 PIK3C2A
4 cardiac arrest 29.7 PIK3C2A NPPB ACE
5 acute myocarditis 29.5 TNNI3 NPPB ACE
6 right bundle branch block 29.5 TNNI3 NPPB ACE
7 congestive heart failure 29.4 TNNI3 PIK3C2A NPPB ACE
8 left bundle branch hemiblock 29.2 TNNI3 PIK3C2A NPPB ACE
9 myocardial infarction 29.2 TNNI3 PIK3C2A NPPB ACE
10 acute myocardial infarction 29.2 TNNI3 PIK3C2A NPPB ACE
11 acute anterolateral myocardial infarction 10.2 PIK3C2A ACE
12 granulomatous myositis 10.2 PIK3C2A ACE
13 spontaneous tension pneumothorax 10.2 TRAPPC9 NPPB
14 anomalous left coronary artery from the pulmonary artery 10.2 TRAPPC9 NPPB
15 silent myocardial infarction 10.2 TNNI3 ACE
16 anterolateral myocardial infarction 10.2 NPPB ACE
17 acute mountain sickness 10.1 PIK3C2A ACE
18 cardiac tuberculosis 10.1 NPPB ACE
19 pseudohyperkalemia, familial, 2, due to red cell leak 10.1 PIK3C2A ACE
20 anuria 10.1 PIK3C2A ACE
21 idiopathic edema 10.1 NPPB ACE
22 coronary artery vasospasm 10.1 TNNI3 ACE
23 first-degree atrioventricular block 10.1 NPPB ACE
24 pulmonary valve insufficiency 10.1 NPPB ACE
25 acute kidney tubular necrosis 10.1 PIK3C2A ACE
26 third-degree atrioventricular block 10.1 NPPB ACE
27 aspiration pneumonia 10.1 PIK3C2A ACE
28 myocardial stunning 10.1 TNNI3 ACE
29 central sleep apnea 10.1 NPPB ACE
30 chronic pulmonary heart disease 10.1 NPPB ACE
31 endocardium disease 10.1 PIK3C2A ACE
32 mitral valve stenosis 10.1 NPPB ACE
33 inferior myocardial infarction 10.1 TNNI3 PIK3C2A NPPB
34 malignant hypertension 10.1 NPPB ACE
35 renovascular hypertension 10.0 NPPB ACE
36 apnea, obstructive sleep 10.0 NPPB ACE
37 renal hypertension 10.0 NPPB ACE
38 rheumatic fever 10.0 NPPB ACE
39 hypertensive heart disease 10.0 NPPB ACE
40 exanthem 10.0 PIK3C2A ACE
41 rheumatic heart disease 10.0 NPPB ACE
42 systolic heart failure 10.0 NPPB ACE
43 intermediate coronary syndrome 9.9 TNNI3 PIK3C2A ACE
44 progressive familial heart block, type ia 9.9
45 diphtheria 9.9
46 paracetamol poisoning 9.9
47 patent ductus arteriosus 1 9.9 NPPB ACE
48 constrictive pericarditis 9.9 TNNI3 NPPB ACE
49 tricuspid valve insufficiency 9.9 TNNI3 NPPB ACE
50 tricuspid valve disease 9.9 TNNI3 NPPB ACE

Graphical network of the top 20 diseases related to Toxic Myocarditis:



Diseases related to Toxic Myocarditis

Symptoms & Phenotypes for Toxic Myocarditis

Drugs & Therapeutics for Toxic Myocarditis

Drugs for Toxic Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Captopril Approved Phase 3 62571-86-2 44093
2 Antihypertensive Agents Phase 3
3 Angiotensin-Converting Enzyme Inhibitors Phase 3
4
protease inhibitors Phase 3
5 HIV Protease Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevention of Chemotherapy Induced Cardiotoxicity in Children With Bone Tumors and Acute Myeloid Leukemia Recruiting NCT03389724 Phase 3 Capoten®

Search NIH Clinical Center for Toxic Myocarditis

Genetic Tests for Toxic Myocarditis

Anatomical Context for Toxic Myocarditis

MalaCards organs/tissues related to Toxic Myocarditis:

40
Bone, Myeloid, Heart, Kidney, Liver

Publications for Toxic Myocarditis

Articles related to Toxic Myocarditis:

(show top 50) (show all 85)
# Title Authors PMID Year
1
Aluminium toxicosis: a review of toxic actions and effects. 61
32206026 2019
2
Cardiogenic Shock Due to Aluminum Phosphide Poisoning Treated with Intra-aortic Balloon Pump: A Report of Two Cases. 61
30949845 2019
3
Chronic Marijuana and Synthetic Cannabinoid-Induced Toxic Myocarditis and End-Stage Cardiomyopathy: Management With Mechanical Circulatory Support as a Bridge-to-Transplantation. 61
30606509 2019
4
Multi-Organ System Injury from Inhalant Abuse. 61
30320538 2019
5
Using Intra-Aortic Balloon Pump for Management of Cardiogenic Shock Following Aluminum Phosphide Poisoning; Report of 3 Cases. 61
29503828 2018
6
Marijuana Induced Myocarditis: A New Entity of Toxic Myocarditis. 61
30533519 2018
7
Clozapine, ziprasidone, and sertindole-induced morphological changes in the rat heart and their relationship to antioxidant enzymes function. 61
30036154 2018
8
Toxic Myocarditis Caused by Acetaminophen in a Multidrug Overdose. 61
28795995 2017
9
Cardiac pathologic findings in 3 unusual cases of sudden cardiac death related to anorexiant drugs. 61
29024685 2017
10
Lethal cardiotoxicity from quaternary ammonium compounds contained in an unguarded household detergent at a psychiatric facility. 61
28784582 2017
11
Cardiac magnetic resonance study of scorpion toxic myocarditis. 61
28040703 2017
12
Reversible Myocardial Injury and Intraventricular Thrombus Associated with Aluminium Phosphide Poisoning. 61
28487776 2017
13
Acute interstitial nephritis, toxic hepatitis and toxic myocarditis following multiple Asian giant hornet stings in Shaanxi Province, China. 61
26910407 2016
14
Inhalant-Abuse Myocarditis Diagnosed by Cardiac Magnetic Resonance. 61
27303242 2016
15
Acute myocarditis and pulmonary edema due to scorpion sting. 61
29043259 2016
16
A Rare Case of Toxic Myocarditis Caused by Bacterial Liver Abscess Mimicking Acute Myocardial Infarction. 61
26726772 2016
17
Recreational phenethylamine poisonings reported to a French poison control center. 61
26205314 2015
18
Clinical comparison of scorpion envenomation by Androctonus mauritanicus and Buthus occitanus in children. 61
25218169 2014
19
Effects of Xin-Ji-Er-Kang formula on 2K1C-induced hypertension and cardiovascular remodeling in rats. 61
25063306 2014
20
Evaluation of left ventricular function by bedside ultrasound in acute toxic myocarditis. 61
23849366 2013
21
Scrub typhus: surveillance, clinical profile and diagnostic issues in Shandong, China. 61
23091193 2012
22
[NDM-1-producing Klebsiella pneumoniae in mainland China]. 61
22898285 2012
23
Acute myocardial infarction in a 56-year-old female patient treated with sulfasalazine. 61
21514761 2012
24
Unresponsive ventricular tachycardia associated with aluminum phosphide poisoning. 61
21406319 2012
25
Frequency and management of troponin I elevation in patients treated with molecular targeted therapies in phase I trials. 61
20924643 2012
26
Initial dose effect of 5-fluorouracil: rapidly improving severe, acute toxic myopericarditis. 61
21208764 2012
27
Transient ST elevation after ketamine intoxication: a new cause of acquired brugada ECG pattern. 61
20384648 2011
28
Bolus fluorouracil induced syncope and pulseless ventricular tachycardia: a case report. 61
21607046 2011
29
Fulminant colitis and toxic myocarditis: a unifying cause? 61
20006131 2009
30
Brugada pattern in toxic myocarditis due to severe aluminum phosphide poisoning. 61
19712068 2009
31
Intra-aortic balloon pump in toxic myocarditis due to aluminum phosphide poisoning. 61
19415593 2009
32
[Cardiac damage due to scorpion envenomation: case involving atrial flutter]. 61
19702162 2009
33
Thoratec left ventricular assist device removal after toxic myocarditis. 61
19022028 2008
34
Toxic myocarditis due to oral ingestion of hydrofluoric acid. 61
17822953 2008
35
[Puerarin in the treatment of poisoning of acute organophosphorous compound with toxic myocarditis]. 61
18928024 2008
36
Cardiac lesions induced by 5-fluorouracil in the rabbit. 61
16866187 2006
37
Cardiac lesions induced by neuroleptic drugs in the rabbit. 61
16410188 2006
38
[Cardiovascular dysfunction following severe scorpion envenomation. Mechanisms and physiopathology]. 61
15687982 2005
39
Aspirin intoxication in a child associated with myocardial necrosis: is this a drug-related lesion? 61
14692648 2003
40
Significance of assessment of serum cardiac troponin I and interleukin-8 in scorpion envenomed children. 61
12565731 2003
41
Drug-induced toxic myocarditis. 61
12638679 2003
42
Acute fatal toxic myocarditis after black widow spider envenomation. 61
12526131 2003
43
Myocardial injury in scorpion envenomed children: significance of assessment of serum troponin I and interleukin-8. 61
12011799 2002
44
Propionyl-L-carnitine as protector against adriamycin-induced cardiomyopathy. 61
11419959 2001
45
[An experimental study on inhibitory effect of xinjierkang granules on virus myocarditis]. 61
12512454 2000
46
Acute myocarditis following Tityus trinitatis envenoming: morphological and pathophysiological characteristics. 61
9920487 1999
47
Cardiac arrhythmias in aluminium phosphide poisoning studied by on continuous holter and cardioscopic monitoring. 61
12152839 1998
48
[Clinical and laboratory studies with typhoid fever 178 patients]. 61
9868065 1997
49
[Carbamate and organophosphate poisoning]. 61
8768022 1996
50
5-Fluorouracil related toxic myocarditis: case reports and pathological confirmation. 61
7954023 1994

Variations for Toxic Myocarditis

Expression for Toxic Myocarditis

Search GEO for disease gene expression data for Toxic Myocarditis.

Pathways for Toxic Myocarditis

GO Terms for Toxic Myocarditis

Biological processes related to Toxic Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.16 NPPB ACE
2 regulation of blood vessel diameter GO:0097746 8.96 NPPB ACE
3 heart contraction GO:0060047 8.62 TNNI3 ACE

Sources for Toxic Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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