MCID: TXC010
MIFTS: 37

Toxic Myocarditis

Categories: Cardiovascular diseases

Aliases & Classifications for Toxic Myocarditis

MalaCards integrated aliases for Toxic Myocarditis:

Name: Toxic Myocarditis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9694
ICD9CM 35 422.93
SNOMED-CT 68 31993003
UMLS 73 C0155691

Summaries for Toxic Myocarditis

MalaCards based summary : Toxic Myocarditis is related to gas gangrene and acute myocardial infarction. An important gene associated with Toxic Myocarditis is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are Cellular Senescence (REACTOME) and fMLP Pathway. Affiliated tissues include bone, myeloid and liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Toxic Myocarditis

Diseases related to Toxic Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 gas gangrene 29.9 PIK3C2A TNNI3
2 acute myocardial infarction 29.8 NPPB PIK3C2A TNNI3
3 myocardial infarction 29.4 NOS3 NPPB NPY PIK3C2A TNNI3
4 myocarditis 10.5
5 tick paralysis 10.2 PIK3C2A TNNI3
6 cardiogenic shock 10.2 NPPB PIK3C2A
7 inferior myocardial infarction 10.2 NPPB PIK3C2A
8 cryptogenic organizing pneumonia 10.2 CXCL8 PIK3C2A
9 erysipelas 10.2 PIK3C2A SOD1
10 tricuspid valve insufficiency 10.2 NPPB ZIC3
11 left bundle branch hemiblock 10.2 NPPB TNNI3
12 coronary artery vasospasm 10.2 NOS3 PIK3C2A
13 acute anterolateral myocardial infarction 10.1 KANTR PIK3C2A
14 pericardium disease 10.1 PIK3C2A TNNI3 ZIC3
15 status asthmaticus 10.1 CXCL8 PIK3C2A
16 central sleep apnea 10.1 NOS3 NPPB
17 tricuspid valve disease 10.1 NPPB ZIC3
18 coronary stenosis 10.1 NPPB PIK3C2A TNNI3
19 posterior myocardial infarction 10.1 KANTR PIK3C2A
20 chronic mountain sickness 10.1 NOS3 NPPB
21 anteroseptal myocardial infarction 10.1 KANTR PIK3C2A
22 endocarditis 10.1 CXCL8 PIK3C2A TNNI3
23 postcholecystectomy syndrome 10.1 KANTR SOD1
24 myocardial stunning 10.1 SOD1 TNNI3
25 leukoregulin 10.1 CXCL8 JUN
26 thyroid crisis 10.1 KANTR ZIC3
27 intracranial vasospasm 10.1 KANTR NOS3
28 angina pectoris 10.1 NOS3 NPPB PIK3C2A
29 alveolar periostitis 10.0 JUN KANTR
30 ischemic heart disease 10.0 NOS3 NPPB
31 tinea favosa 10.0 MAPK8 NOS3
32 sleep apnea 10.0 CXCL8 NOS3 NPPB
33 photokeratitis 10.0 JUN NOS3
34 acute chest syndrome 10.0 CXCL8 NOS3
35 chronic kidney failure 10.0 NOS3 NPPB SOD1
36 coronary artery anomaly 10.0 NOS3 NPPB PIK3C2A TNNI3
37 diastolic heart failure 10.0 NOS3 NPPB
38 tetralogy of fallot 9.9 NPPB NPY SOD1
39 pulmonary edema 9.9 CXCL8 NOS3 NPPB PIK3C2A
40 diphtheria 9.9
41 paracetamol poisoning 9.9
42 tetrahydrobiopterin deficiency 9.9 NOS3 SOD1
43 arteries, anomalies of 9.9 KANTR NOS3 NPPB TNNI3
44 hepatitis 9.8
45 colitis 9.8
46 common cold 9.8
47 interstitial nephritis 9.8
48 cutaneous diphtheria 9.8
49 peritonitis 9.8
50 heart disease 9.7 CXCL8 NOS3 NPPB PIK3C2A TNNI3 ZIC3

Graphical network of the top 20 diseases related to Toxic Myocarditis:



Diseases related to Toxic Myocarditis

Symptoms & Phenotypes for Toxic Myocarditis

GenomeRNAi Phenotypes related to Toxic Myocarditis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.64 PIK3C2A
2 Decreased viability GR00221-A-1 9.64 MAPK8 PIK3C2A
3 Decreased viability GR00221-A-2 9.64 JUN MAPK8 PIK3C2A SOD1
4 Decreased viability GR00221-A-3 9.64 JUN SOD1
5 Decreased viability GR00221-A-4 9.64 PIK3C2A SOD1
6 Decreased viability GR00240-S-1 9.64 PIK3C2A
7 Decreased viability GR00342-S-1 9.64 PIK3C2A
8 Decreased viability GR00342-S-2 9.64 MAPK8 PIK3C2A
9 Decreased viability GR00342-S-3 9.64 MAPK8 PIK3C2A
10 Decreased viability GR00402-S-2 9.64 JUN MAPK8 PIK3C2A SOD1

MGI Mouse Phenotypes related to Toxic Myocarditis:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.15 CYBB JUN MAPK8 NOS3 NPY PIK3C2A
2 cardiovascular system MP:0005385 10.13 ATP11A CYBB JUN MAPK8 NOS3 PIK3C2A
3 growth/size/body region MP:0005378 10.09 ATP11A CYBB JUN MAPK8 NOS3 NPY
4 cellular MP:0005384 10.06 ATP11A CYBB JUN MAPK8 NOS3 PIK3C2A
5 hematopoietic system MP:0005397 10.01 ATP11A CYBB JUN MAPK8 NOS3 PIK3C2A
6 immune system MP:0005387 9.97 ATP11A CYBB JUN MAPK8 NOS3 PIK3C2A
7 adipose tissue MP:0005375 9.91 CYBB MAPK8 NOS3 NPY PIK3C2A
8 liver/biliary system MP:0005370 9.87 ATP11A JUN MAPK8 NOS3 NPY SOD1
9 nervous system MP:0003631 9.81 ATP11A CYBB JUN MAPK8 NOS3 NPY
10 muscle MP:0005369 9.73 ATP11A CYBB MAPK8 NOS3 SOD1 TNNI3
11 respiratory system MP:0005388 9.43 ATP11A JUN MAPK8 NOS3 TNNI3 ZIC3
12 vision/eye MP:0005391 9.1 ATP11A JUN MAPK8 NOS3 SOD1 ZIC3

Drugs & Therapeutics for Toxic Myocarditis

Search Clinical Trials , NIH Clinical Center for Toxic Myocarditis

Genetic Tests for Toxic Myocarditis

Anatomical Context for Toxic Myocarditis

MalaCards organs/tissues related to Toxic Myocarditis:

41
Bone, Myeloid, Liver, Kidney, Heart, Thyroid

Publications for Toxic Myocarditis

Articles related to Toxic Myocarditis:

(show all 26)
# Title Authors Year
1
Marijuana Induced Myocarditis: A New Entity of Toxic Myocarditis. ( 30533519 )
2018
2
Toxic Myocarditis Caused by Acetaminophen in a Multidrug Overdose. ( 28795995 )
2017
3
Acute interstitial nephritis, toxic hepatitis and toxic myocarditis following multiple Asian giant hornet stings in Shaanxi Province, China. ( 26910407 )
2016
4
A Rare Case of Toxic Myocarditis Caused by Bacterial Liver Abscess Mimicking Acute Myocardial Infarction. ( 26726772 )
2016
5
Cardiac magnetic resonance study of scorpion toxic myocarditis. ( 28040703 )
2016
6
Evaluation of left ventricular function by bedside ultrasound in acute toxic myocarditis. ( 23849366 )
2013
7
Fulminant colitis and toxic myocarditis: a unifying cause? ( 20006131 )
2009
8
Intra-aortic balloon pump in toxic myocarditis due to aluminum phosphide poisoning. ( 19415593 )
2009
9
Brugada pattern in toxic myocarditis due to severe aluminum phosphide poisoning. ( 19712068 )
2009
10
Toxic myocarditis due to oral ingestion of hydrofluoric acid. ( 17822953 )
2008
11
Thoratec left ventricular assist device removal after toxic myocarditis. ( 19022028 )
2008
12
Acute fatal toxic myocarditis after black widow spider envenomation. ( 12526131 )
2003
13
Drug-induced toxic myocarditis. ( 12638679 )
2003
14
5-Fluorouracil related toxic myocarditis: case reports and pathological confirmation. ( 7954023 )
1994
15
Toxic myocarditis in paracetamol poisoning. ( 3122934 )
1988
16
Toxic myocarditis in paracetamol poisoning. ( 3120894 )
1987
17
Toxic myocarditis with resultant arrhythmias due to scorpion sting. ( 7320003 )
1981
18
Survival after major burn complicated by gas gangrene, acute renal failure, and toxic myocarditis. ( 435749 )
1979
19
Toxic myocarditis due to scorpion bite--a case report. ( 5835669 )
1965
20
Toxic myocarditis. Report of a case arising from ingestion of liquid plastic catalyst. ( 13886477 )
1962
21
Steroid treatment of infectious toxic myocarditis. ( 13762672 )
1960
22
A case of toxic myocarditis due to the common cold with an unusual type of electrocardiogram. ( 14393180 )
1955
23
Primary streptococcic peritonitis with complicating toxic myocarditis and pulmonary emboli; a report of a case with eventual recovery. ( 18896519 )
1947
24
Cutaneous diphtheria with toxic myocarditis; report of fatal case with necropsy findings. ( 20278466 )
1947
25
Toxic myocarditis. ( 20276781 )
1946
26
Diphtheria; toxic myocarditis; diphtheria with nephritis. ( 20982899 )
1946

Variations for Toxic Myocarditis

Expression for Toxic Myocarditis

Search GEO for disease gene expression data for Toxic Myocarditis.

Pathways for Toxic Myocarditis

Pathways related to Toxic Myocarditis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 CXCL8 CYBB JUN MAPK8 SOD1
2
Show member pathways
12.82 JUN MAPK8 NOS3 PIK3C2A ZIC3
3
Show member pathways
12.22 JUN MAPK8 NOS3 PIK3C2A
4
Show member pathways
12.17 CXCL8 CYBB JUN MAPK8 NOS3
5
Show member pathways
12.12 CYBB JUN MAPK8
6
Show member pathways
12.08 CXCL8 JUN MAPK8
7
Show member pathways
12.08 MAPK8 NOS3 PIK3C2A
8
Show member pathways
12.04 JUN MAPK8 NPY TNNI3
9 12.03 JUN MAPK8 NOS3
10
Show member pathways
12.01 CXCL8 JUN MAPK8
11
Show member pathways
12 JUN MAPK8 PIK3C2A
12 11.92 JUN MAPK8 NOS3
13
Show member pathways
11.87 JUN MAPK8 NOS3
14
Show member pathways
11.86 JUN MAPK8 PIK3C2A
15 11.82 JUN MAPK8 PIK3C2A
16 11.7 CXCL8 MAPK8 NOS3
17 11.66 CXCL8 JUN MAPK8
18
Show member pathways
11.63 CXCL8 JUN MAPK8
19 11.61 CXCL8 JUN MAPK8
20 11.57 CXCL8 JUN MAPK8
21
Show member pathways
11.52 CXCL8 CYBB JUN SOD1
22 11.49 JUN MAPK8 SOD1
23
Show member pathways
11.38 JUN MAPK8 NOS3 PIK3C2A
24 11.37 CXCL8 JUN MAPK8
25 11.29 CXCL8 JUN MAPK8
26 11.15 JUN MAPK8
27 11.11 JUN MAPK8
28 11.11 JUN MAPK8
29 11.08 CXCL8 JUN NOS3
30 11.08 JUN MAPK8 NOS3 SOD1
31 11.07 JUN MAPK8
32 11.06 JUN MAPK8
33 11.04 JUN MAPK8
34 11.02 CXCL8 CYBB JUN MAPK8 NOS3
35 11.01 CXCL8 MAPK8
36 11.01 JUN MAPK8
37 10.68 JUN MAPK8

GO Terms for Toxic Myocarditis

Biological processes related to Toxic Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.61 CXCL8 CYBB NOS3
2 superoxide metabolic process GO:0006801 9.46 CYBB SOD1
3 regulation of blood vessel size GO:0050880 9.4 NOS3 NPPB
4 heart contraction GO:0060047 9.37 SOD1 TNNI3
5 removal of superoxide radicals GO:0019430 9.32 NOS3 SOD1
6 superoxide anion generation GO:0042554 9.26 CYBB SOD1
7 regulation of blood pressure GO:0008217 9.26 NOS3 NPPB NPY SOD1
8 hydrogen peroxide biosynthetic process GO:0050665 9.16 CYBB SOD1
9 cellular response to cadmium ion GO:0071276 8.92 CYBB JUN MAPK8 SOD1

Sources for Toxic Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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