MCID: TXC020
MIFTS: 37

Toxic Oil Syndrome

Categories: Rare diseases

Aliases & Classifications for Toxic Oil Syndrome

MalaCards integrated aliases for Toxic Oil Syndrome:

Name: Toxic Oil Syndrome 60

Characteristics:

Orphanet epidemiological data:

60
toxic oil syndrome
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

UMLS via Orphanet 75 C0409998
Orphanet 60 ORPHA227972

Summaries for Toxic Oil Syndrome

MalaCards based summary : Toxic Oil Syndrome is related to eosinophilia-myalgia syndrome and eosinophilic fasciitis. An important gene associated with Toxic Oil Syndrome is AHR (Aryl Hydrocarbon Receptor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. Affiliated tissues include lung, b cells and t cells, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Wikipedia : 77 Toxic oil syndrome or simply toxic syndrome (Spanish: síndrome del aceite tóxico or síndrome tóxico) is... more...

Related Diseases for Toxic Oil Syndrome

Diseases related to Toxic Oil Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 eosinophilia-myalgia syndrome 30.5 AHR IFNG IL5
2 eosinophilic fasciitis 29.8 AHR IFNG IL5
3 hypereosinophilic syndrome 29.4 IGHE IL2RA IL4 IL5
4 aryl hydrocarbon hydroxylase inducibility 10.4 AHR CYP1A1
5 fascioliasis 10.2 CP IFNG
6 multiple chemical sensitivity 10.2 CYP2D6 NAT2
7 b cell prolymphocytic leukemia 10.2 FCER2 IL2RA
8 chronic active epstein-barr virus infection 10.2 IDO1 IFNG
9 thoracic outlet syndrome 10.2
10 persistent polyclonal b-cell lymphocytosis 10.2 FCER2 IL4
11 staphylococcal toxic shock syndrome 10.2 IFNG IGHE
12 large granular lymphocyte leukemia 10.2 IFNG IL2RA
13 granulocytopenia 10.2 CP NAT2
14 chronic graft versus host disease 10.2 IFNG IL2RA
15 fasciitis 10.2
16 drug-induced hepatitis 10.1 CYP2D6 GSTM1 NAT2
17 b-cell growth factor 10.1 IFNG IL4
18 baylisascariasis 10.1 IFNG IL4
19 penicillin allergy 10.1 IFNG IL4
20 crustacean allergy 10.1 IFNG IL4
21 bladder disease 10.1 GSTM1 IDO1 NAT2
22 peanut allergy 10.1 IFNG IGHE
23 intermediate uveitis 10.1 IFNG IL2RA
24 pulmonary hypertension 10.1
25 hypersplenism 10.1 IFNG IL2RA
26 cephalosporin allergy 10.0 IFNG IL5
27 eales disease 10.0 CP IFNG IL4
28 behcet syndrome 10.0 CP IFNG IL2RA
29 immunodeficiency with hyper-igm, type 1 10.0 IGHE IL4
30 norwegian scabies 10.0 GSTM1 IL5
31 posterior uveitis 10.0 IFNG IL2RA
32 orofacial granulomatosis 10.0 IFNG IL4
33 strongyloidiasis 10.0 IFNG IL5
34 buruli ulcer 10.0 IFNG IL4
35 multicentric castleman disease 10.0 IFNG IL5
36 primary systemic mycosis 10.0 IFNG IL4
37 chlamydia 9.9 IDO1 IFNG IL4
38 trypanosomiasis 9.9 IDO1 IFNG IL4
39 pulmonary hypertension, primary, 1 9.9
40 mycoplasma pneumoniae pneumonia 9.9 IFNG IL4
41 oral cavity cancer 9.9 CP CYP1A1 GSTM1 IL4
42 dendritic cell tumor 9.9 FCER2 IFNG
43 pulmonary tuberculosis 9.9 IFNG IL4 NAT2
44 hyperlucent lung 9.9 IFNG IL2RA IL4
45 mycobacterium tuberculosis 1 9.9 IFNG IL4 NAT2
46 cough variant asthma 9.9 IL4 IL5
47 inflammatory bowel disease 4 9.9 IL4 IL5
48 sulfamethoxazole allergy 9.9 IL4 IL5
49 angiostrongyliasis 9.9 IL4 IL5
50 hyper ige syndrome 9.9 IFNG IGHE IL4

Graphical network of the top 20 diseases related to Toxic Oil Syndrome:



Diseases related to Toxic Oil Syndrome

Symptoms & Phenotypes for Toxic Oil Syndrome

GenomeRNAi Phenotypes related to Toxic Oil Syndrome according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 AHR GSTM1 IDO1 IL2RA IL5 PNLIP

MGI Mouse Phenotypes related to Toxic Oil Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 AHR CP CYP1A1 FCER2 IDO1 IFNG
2 homeostasis/metabolism MP:0005376 9.9 AHR CP CYP1A1 FCER2 IDO1 IFNG
3 digestive/alimentary MP:0005381 9.87 AHR FCER2 IFNG IL2RA IL4 IL5
4 immune system MP:0005387 9.61 AHR CP CYP1A1 FCER2 IDO1 IFNG
5 liver/biliary system MP:0005370 9.17 AHR CP CYP1A1 IFNG IL4 IL5

Drugs & Therapeutics for Toxic Oil Syndrome

Search Clinical Trials , NIH Clinical Center for Toxic Oil Syndrome

Genetic Tests for Toxic Oil Syndrome

Anatomical Context for Toxic Oil Syndrome

MalaCards organs/tissues related to Toxic Oil Syndrome:

42
Lung, B Cells, T Cells, Skin, Endothelial, Bone Marrow, Myeloid

Publications for Toxic Oil Syndrome

Articles related to Toxic Oil Syndrome:

(show top 50) (show all 199)
# Title Authors Year
1
Potential implication of aniline derivatives in the Toxic Oil Syndrome (TOS). ( 20970410 )
2011
2
Proteomics of toxic oil syndrome in humans: Phenotype distribution in a population of patients. ( 21075095 )
2011
3
Contribution of denaturing and deodorization processes of oils to toxic oil syndrome. ( 21238434 )
2011
4
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? ( 19941898 )
2010
5
High prevalence of cardiovascular risk in patients with toxic oil syndrome: a comparative study using the general Spanish population. ( 18206599 )
2008
6
Studies on toxic oil syndrome: development of an enzyme-linked immunosorbent assay for 3-(N-phenylamino)propane-1,2-diol in human urine. ( 18418587 )
2008
7
Effects of toxic oil syndrome on the psychological conditions of the descendants of affected persons. ( 19186503 )
2008
8
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome. ( 17892268 )
2007
9
In vitro bioactivation of 3-(N-phenylamino)propane-1,2-diol by human and rat liver microsomes and recombinant P450 enzymes. Implications for toxic oil syndrome. ( 17672514 )
2007
10
Strain-dependent acute lung injury after intra-tracheal administration of a 'refined' aniline-denatured rapeseed oil: a murine model of the toxic oil syndrome? ( 17686560 )
2007
11
Genetic approaches in the understanding of Toxic Oil Syndrome. ( 16236472 )
2006
12
Endocytosis and intracellular trafficking of fatty acid esters of phenylaminopropanediol, the putative etiologic agents of the toxic oil syndrome (TOS). ( 16343824 )
2006
13
Proteotyping of human haptoglobin by MALDI-TOF profiling: Phenotype distribution in a population of toxic oil syndrome patients. ( 16544284 )
2006
14
On the generation and outcome of 3-(N-phenylamino)propane-1,2-diol derivatives in deodorized model oils related to toxic oil syndrome. ( 15833026 )
2005
15
Quality of life, disability and handicap in patients with toxic oil syndrome. ( 15926964 )
2005
16
Toxic oil syndrome: genetic restriction and immunomodulatory effects due to adulterated oils in a model of HLA transgenic mice. ( 15979827 )
2005
17
Synthesis and stability studies of the glutathione and N-acetylcysteine adducts of an iminoquinone reactive intermediate generated in the biotransformation of 3-(N-phenylamino)propane-1,2-diol: implications for toxic oil syndrome. ( 16300381 )
2005
18
Review article toxic oil syndrome: review of immune aspects of the disease. ( 18958659 )
2005
19
Determination of protein markers in human serum: Analysis of protein expression in toxic oil syndrome studies. ( 14760700 )
2004
20
The limits of epidemiology and the Spanish Toxic Oil Syndrome. ( 15166211 )
2004
21
Studies on toxic oil syndrome: stereoselective hydrolysis of 3-(phenylamino)propane-1,2-diol esters by human pancreatic lipase. ( 15257613 )
2004
22
Induction of c-fos messenger RNA by 3-(N-phenylamino)-1,2-propanediol esters, compounds related to Toxic Oil Syndrome. ( 15501433 )
2004
23
Spanish toxic oil syndrome. ( 12617023 )
2003
24
Neurologic outcomes of toxic oil syndrome patients 18 years after the epidemic. ( 12896854 )
2003
25
Toxic oil syndrome: survival in the whole cohort between 1981 and 1995. ( 12921940 )
2003
26
Characteristics of disability and handicap among Toxic Oil Syndrome (TOS) cohort patients: a cross-sectional study, 17 years after the original food intoxication. ( 14534059 )
2003
27
Strain-dependent in vitro and in vivo effects of oleic acid anilides on splenocytes and T cells in a murine model of the toxic oil syndrome. ( 11731032 )
2002
28
N-Acetyltransferase 2 polymorphism in patients with Spanish toxic oil syndrome. ( 11813699 )
2002
29
The Spanish toxic oil syndrome 20 years after its onset: a multidisciplinary review of scientific knowledge. ( 12003748 )
2002
30
A search for an animal model of the Spanish toxic oil syndrome. ( 12176082 )
2002
31
T cells ignore aniline, a prohapten, but respond to its reactive metabolites generated by phagocytes: possible implications for the pathogenesis of toxic oil syndrome. ( 11304127 )
2001
32
Pharmacogenetic profile of xenobiotic enzyme metabolism in survivors of the Spanish toxic oil syndrome. ( 11335185 )
2001
33
The toxic oil syndrome: 20 years on. ( 11501225 )
2001
34
Metabolism of (R)- and (S)-3-(phenylamino)propane-1,2-diol in C57BL/6- and A/J-strain mice. Identification of new metabolites with potential toxicological significance to the toxic oil syndrome. ( 11511184 )
2001
35
Determination of aniline derivatives in oils related to the toxic oil syndrome by atmospheric pressure ionization-tandem mass spectrometry. ( 11534704 )
2001
36
Metabolism of R,S enantiomers of 3-phenylamino-1,2-propanediol, a compound associated with the toxic oil syndrome, in C57BL/6- and A/J-strain mice. ( 11764992 )
2001
37
Absorption and effects of 3-(N-phenylamino)-1,2-propanediol esters in relation to toxic oil syndrome. ( 11768157 )
2001
38
Toxic oil syndrome: the perspective after 20 years. ( 12192735 )
2001
39
DR2 antigens are associated with severity of disease in toxic oil syndrome (TOS). ( 10746782 )
2000
40
Toxic oil syndrome (TOS). Foreword. ( 10889513 )
2000
41
Pentachlorophenol and pentachloroanisole in oil samples associated with the toxic oil syndrome. ( 9870982 )
1999
42
Epidemiologic evidence for a new class of compounds associated with toxic oil syndrome. ( 10069247 )
1999
43
Late deaths among young women affected by the toxic oil syndrome in Spain. ( 10230849 )
1999
44
Involvement of nuclear factor-kappaB in a murine model for the acute form of autoimmune-like toxic oil syndrome. ( 10373405 )
1999
45
Fatty acid anilides: in vivo formation and relevance to toxic oil syndrome. ( 10402561 )
1999
46
Biotransformation and clearance of 3-(phenylamino)propane-1,2-diol, a compound present in samples related to toxic oil syndrome, in C57BL/6 and A/J mice. ( 10604860 )
1999
47
The acute pathology of fatty acid anilides and linoleic diester of 3-phenylamino-1,2-propanediol in mice: possible implication as aetiologic agents for the toxic oil syndrome. ( 10650923 )
1999
48
Rapid HPLC screening method for contaminants found in implicated L-tryptophan associated with eosinophilia myalgia syndrome and adulterated rapeseed oil associated with toxic oil syndrome. ( 9787895 )
1998
49
Strain-dependent cytokine profile and susceptibility to oleic acid anilide in a murine model of the toxic oil syndrome. ( 9473529 )
1998
50
Health status measurement in Toxic Oil Syndrome. ( 9762880 )
1998

Variations for Toxic Oil Syndrome

Expression for Toxic Oil Syndrome

Search GEO for disease gene expression data for Toxic Oil Syndrome.

Pathways for Toxic Oil Syndrome

Pathways related to Toxic Oil Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.19 FCER2 IFNG IGHE IL2RA IL4 IL5
2 12.65 GSTM1 IFNG IL2RA IL4 IL5
3
Show member pathways
12.48 IFNG IGHE IL2RA IL4
4
Show member pathways
12.43 AHR IFNG IL2RA IL4 IL5
5 12.38 IDO1 IFNG IL2RA IL4
6
Show member pathways
12.22 IFNG IL2RA IL4 IL5
7
Show member pathways
12.09 IFNG IL2RA IL4 IL5
8
Show member pathways
11.93 IFNG IL2RA IL4 IL5
9 11.82 FCER2 IGHE IL4
10 11.82 IFNG IL2RA IL4 IL5
11
Show member pathways
11.81 IFNG IL2RA IL4
12 11.69 FCER2 IL2RA IL4 IL5
13 11.64 IFNG IL4 IL5
14
Show member pathways
11.61 CYP1A1 CYP2D6 GSTM1
15
Show member pathways
11.55 IFNG IL2RA IL4 IL5
16 11.42 FCER2 IGHE IL4 IL5
17 11.37 AHR CYP1A1 IFNG
18 11.22 IFNG IL2RA IL4 IL5
19 11.12 IFNG IL4 IL5
20
Show member pathways
11.1 IFNG IL2RA
21 11.08 IFNG IL2RA
22 11.02 IFNG IL4 IL5
23 11 CYP1A1 GSTM1
24 10.98 IFNG IL2RA IL4 IL5
25 10.92 AHR IFNG IL2RA IL4 IL5
26
Show member pathways
10.8 CYP1A1 CYP2D6
27 10.76 AHR IFNG IL4 IL5

GO Terms for Toxic Oil Syndrome

Cellular components related to Toxic Oil Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 CP FCER2 IFNG IGHE IL4 IL5

Biological processes related to Toxic Oil Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.55 IFNG IGHE IL2RA IL4 IL5
2 xenobiotic metabolic process GO:0006805 9.54 AHR CYP2D6 NAT2
3 drug metabolic process GO:0017144 9.49 CYP1A1 CYP2D6
4 positive regulation of interleukin-12 production GO:0032735 9.48 IDO1 IFNG
5 long-chain fatty acid biosynthetic process GO:0042759 9.46 CYP1A1 CYP2D6
6 positive regulation of T cell differentiation GO:0045582 9.43 IL2RA IL4
7 regulation of regulatory T cell differentiation GO:0045589 9.4 IFNG IL2RA
8 coumarin metabolic process GO:0009804 9.32 CYP1A1 CYP2D6
9 heterocycle metabolic process GO:0046483 9.26 CYP1A1 CYP2D6
10 cytokine-mediated signaling pathway GO:0019221 9.02 FCER2 IGHE IL2RA IL4 IL5
11 positive regulation of killing of cells of other organism GO:0051712 8.96 FCER2 IFNG

Molecular functions related to Toxic Oil Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.26 CYP1A1 CYP2D6
2 steroid hydroxylase activity GO:0008395 9.16 CYP1A1 CYP2D6
3 aromatase activity GO:0070330 8.96 CYP1A1 CYP2D6
4 heme binding GO:0020037 8.8 CYP1A1 CYP2D6 IDO1

Sources for Toxic Oil Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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