MCID: TXC020
MIFTS: 34

Toxic Oil Syndrome

Categories: Rare diseases

Aliases & Classifications for Toxic Oil Syndrome

MalaCards integrated aliases for Toxic Oil Syndrome:

Name: Toxic Oil Syndrome 59

Characteristics:

Orphanet epidemiological data:

59
toxic oil syndrome
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

UMLS via Orphanet 73 C0409998
Orphanet 59 ORPHA227972

Summaries for Toxic Oil Syndrome

MalaCards based summary : Toxic Oil Syndrome is related to eosinophilia-myalgia syndrome and eosinophilic fasciitis. An important gene associated with Toxic Oil Syndrome is AHR (Aryl Hydrocarbon Receptor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. Affiliated tissues include lung, liver and skin, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Wikipedia : 75 Toxic oil syndrome or simply toxic syndrome (Spanish: sA?ndrome del aceite tA3xico or sA?ndrome tA3xico)... more...

Related Diseases for Toxic Oil Syndrome

Diseases related to Toxic Oil Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 eosinophilia-myalgia syndrome 31.0 IL5 IFNG AHR
2 eosinophilic fasciitis 30.3 IL5 IFNG AHR
3 autoimmune disease 30.2 IL4 IL2RA IFNG
4 hypereosinophilic syndrome 30.0 IL5 IL4 IL2RA IGHE
5 proteasome-associated autoinflammatory syndrome 1 28.8 IL5 IL4 IGHE IFNG
6 aryl hydrocarbon hydroxylase inducibility 10.7 CYP1A1 AHR
7 persistent polyclonal b-cell lymphocytosis 10.5 IL4 FCER2
8 b cell prolymphocytic leukemia 10.5 IL2RA FCER2
9 systemic scleroderma 10.4
10 large granular lymphocyte leukemia 10.4 IL2RA IFNG
11 fascioliasis 10.4 IFNG CP
12 chronic graft versus host disease 10.4 IL2RA IFNG
13 chronic active epstein-barr virus infection 10.4 IFNG IDO1
14 b-cell growth factor 10.4 IL4 IFNG
15 penicillin allergy 10.4 IL4 IFNG
16 baylisascariasis 10.4 IL4 IFNG
17 crustacean allergy 10.3 IL4 IFNG
18 pulmonary hypertension 10.3
19 cephalosporin allergy 10.3 IL5 IFNG
20 staphylococcal toxic shock syndrome 10.3 IGHE IFNG
21 strongyloidiasis 10.3 IL5 IFNG
22 dendritic cell tumor 10.3 IFNG FCER2
23 multiple chemical sensitivity 10.3 NAT2 CYP2D6
24 fasciitis 10.3
25 norwegian scabies 10.2 IL5 GSTM1
26 cough variant asthma 10.2 IL5 IL4
27 sulfamethoxazole allergy 10.2 IL5 IL4
28 multicentric castleman disease 10.2 IL5 IFNG
29 inflammatory bowel disease 4 10.2 IL5 IL4
30 hypersplenism 10.2 IL2RA IFNG
31 trichinosis 10.2 IL5 IL4
32 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
33 angiostrongyliasis 10.2 IL5 IL4
34 apple allergy 10.2 IL5 IL4
35 intermediate uveitis 10.2 IL2RA IFNG
36 gaucher disease, type ii 10.2 IL5 IL4
37 non-suppurative otitis media 10.2 IL5 IL4
38 orofacial granulomatosis 10.2 IL4 IFNG
39 eales disease 10.2 IL4 IFNG CP
40 granulocytopenia 10.2 NAT2 CP
41 eosinophilic meningitis 10.2 IL5 IL4
42 vasculitis 10.2
43 immunodeficiency with hyper-igm, type 1 10.2 IL4 IGHE
44 eosinophilic gastritis 10.2 IL5 IL4
45 filarial elephantiasis 10.1 IL5 IL4
46 chronic tic disorder 10.1 IL5 IL4
47 intestinal schistosomiasis 10.1 IL5 IL4
48 peanut allergy 10.1 IGHE IFNG
49 behcet syndrome 10.1 IL2RA IFNG CP
50 kimura disease 10.1 IL5 IL4

Graphical network of the top 20 diseases related to Toxic Oil Syndrome:



Diseases related to Toxic Oil Syndrome

Symptoms & Phenotypes for Toxic Oil Syndrome

GenomeRNAi Phenotypes related to Toxic Oil Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 AHR GSTM1 IDO1 IL2RA IL5 PNLIP

MGI Mouse Phenotypes related to Toxic Oil Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 AHR CP CYP1A1 FCER2 IDO1 IFNG
2 homeostasis/metabolism MP:0005376 9.9 AHR CP CYP1A1 FCER2 IDO1 IFNG
3 digestive/alimentary MP:0005381 9.87 AHR FCER2 IFNG IL2RA IL4 IL5
4 immune system MP:0005387 9.61 AHR CP CYP1A1 FCER2 IDO1 IFNG
5 liver/biliary system MP:0005370 9.17 AHR CP CYP1A1 IFNG IL4 IL5

Drugs & Therapeutics for Toxic Oil Syndrome

Search Clinical Trials , NIH Clinical Center for Toxic Oil Syndrome

Genetic Tests for Toxic Oil Syndrome

Anatomical Context for Toxic Oil Syndrome

MalaCards organs/tissues related to Toxic Oil Syndrome:

41
Lung, Liver, Skin, Heart, Testes, Bone, T Cells

Publications for Toxic Oil Syndrome

Articles related to Toxic Oil Syndrome:

(show top 50) (show all 315)
# Title Authors PMID Year
1
[Hypereosinophilic syndrome and other rheumatic diseases with hypereosinophilia]. 38
30937528 2019
2
Peak AAA fatty acid homolog contaminants present in the dietary supplement l-Tryptophan associated with the onset of eosinophilia-myalgia syndrome. 38
29800716 2018
3
C/EBPβ-Thr217 Phosphorylation Stimulates Macrophage Inflammasome Activation and Liver Injury. 38
27067260 2016
4
Human adjuvant-related syndrome or autoimmune/inflammatory syndrome induced by adjuvants. Where have we come from? Where are we going? A proposal for new diagnostic criteria. 38
25813870 2015
5
Morphological clues in the diagnosis of sclerodermiform dermatitis. 38
24423930 2014
6
Diagnosis and classification of eosinophilic fasciitis. 38
24424187 2014
7
Survival in pulmonary hypertension in Spain: insights from the Spanish registry. 38
22362843 2012
8
Severe eosinophilic syndrome associated with the use of probiotic supplements: a new entity? 38
23259129 2012
9
Environmental- and injury-related epidemic-assistance investigations, 1946-2005. 38
22135395 2011
10
Contribution of denaturing and deodorization processes of oils to toxic oil syndrome. 38
21238434 2011
11
Proteomics of toxic oil syndrome in humans: Phenotype distribution in a population of patients. 38
21075095 2011
12
Potential implication of aniline derivatives in the Toxic Oil Syndrome (TOS). 38
20970410 2011
13
[Political change, disease and healthcare reform: the response to the Toxic Oil Syndrome (Spain, 1981-1998)]. 38
22375302 2011
14
Diet in dermatology: revisited. 38
20228538 2010
15
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? 38
19941898 2010
16
[Skin manifestations of toxic syndrome due to denatured rapeseed oil]. 38
20038361 2009
17
[Eosinophilia myalgia syndrome (EMS) caused by L-tryptophan product and toxic oil syndrome (TOS) caused by denatured rape-seed oil]. 38
20065617 2009
18
Effects of toxic oil syndrome on the psychological conditions of the descendants of affected persons. 38
19186503 2008
19
Studies on toxic oil syndrome: development of an enzyme-linked immunosorbent assay for 3-(N-phenylamino)propane-1,2-diol in human urine. 38
18418587 2008
20
High prevalence of cardiovascular risk in patients with toxic oil syndrome: a comparative study using the general Spanish population. 38
18206599 2008
21
Strain-dependent acute lung injury after intra-tracheal administration of a 'refined' aniline-denatured rapeseed oil: a murine model of the toxic oil syndrome? 38
17686560 2007
22
[Current differential diagnosis of hypereosinophilic syndrome]. 38
18666600 2007
23
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome. 38
17892268 2007
24
In vitro bioactivation of 3-(N-phenylamino)propane-1,2-diol by human and rat liver microsomes and recombinant P450 enzymes. Implications for toxic oil syndrome. 38
17672514 2007
25
LC-MS ion maps for the characterization of aniline derivatives of fatty acids and triglycerides in laboratory-denatured rapeseed oil. 38
17295417 2007
26
Endocytosis and intracellular trafficking of fatty acid esters of phenylaminopropanediol, the putative etiologic agents of the toxic oil syndrome (TOS). 38
16343824 2006
27
Proteotyping of human haptoglobin by MALDI-TOF profiling: Phenotype distribution in a population of toxic oil syndrome patients. 38
16544284 2006
28
Drug-, toxin-, and radiation therapy-induced eosinophilic pneumonia. 38
16612770 2006
29
Genetic approaches in the understanding of Toxic Oil Syndrome. 38
16236472 2006
30
[Pulmonary hypertension during exercise in toxic oil syndrome]. 38
16324479 2005
31
Synthesis and stability studies of the glutathione and N-acetylcysteine adducts of an iminoquinone reactive intermediate generated in the biotransformation of 3-(N-phenylamino)propane-1,2-diol: implications for toxic oil syndrome. 38
16300381 2005
32
Toxic oil syndrome: genetic restriction and immunomodulatory effects due to adulterated oils in a model of HLA transgenic mice. 38
15979827 2005
33
Immunotoxic response of oleic acid anilide and its hydrolysis products in female MRL (+/+) mice. 38
18958679 2005
34
[Lung function testing in patients with pulmonary arterial hypertension]. 38
16029731 2005
35
Quality of life, disability and handicap in patients with toxic oil syndrome. 38
15926964 2005
36
On the generation and outcome of 3-(N-phenylamino)propane-1,2-diol derivatives in deodorized model oils related to toxic oil syndrome. 38
15833026 2005
37
Miliary tuberculosis in a patient with eosinophilic fasciitis. 38
15678644 2005
38
Review article toxic oil syndrome: review of immune aspects of the disease. 38
18958659 2005
39
Induction of c-fos messenger RNA by 3-(N-phenylamino)-1,2-propanediol esters, compounds related to Toxic Oil Syndrome. 38
15501433 2004
40
Studies on toxic oil syndrome: stereoselective hydrolysis of 3-(phenylamino)propane-1,2-diol esters by human pancreatic lipase. 38
15257613 2004
41
Spontaneous coronary dissection during postpartum: etiology and controversies in management. 38
15487278 2004
42
The limits of epidemiology and the Spanish Toxic Oil Syndrome. 38
15166211 2004
43
Determination of protein markers in human serum: Analysis of protein expression in toxic oil syndrome studies. 38
14760700 2004
44
[Diagnostic performance of echocardiography in the follow-up of patients with toxic oil syndrome]. 38
14670272 2003
45
[Review of ethical aspects in biomedical research. The experience of the Ethics Committee of the Center for Toxic Oil Syndrome and Rare Diseases [CISATER]]. 38
14670259 2003
46
Characteristics of disability and handicap among Toxic Oil Syndrome (TOS) cohort patients: a cross-sectional study, 17 years after the original food intoxication. 38
14534059 2003
47
[Prevalence of cardiovascular risk factors in a cohort of affected by the toxic oil syndrome]. 38
14563269 2003
48
Neurologic outcomes of toxic oil syndrome patients 18 years after the epidemic. 38
12896854 2003
49
Toxic oil syndrome: survival in the whole cohort between 1981 and 1995. 38
12921940 2003
50
Scleromyxoedema-like changes in four renal dialysis patients. 38
12653751 2003

Variations for Toxic Oil Syndrome

Expression for Toxic Oil Syndrome

Search GEO for disease gene expression data for Toxic Oil Syndrome.

Pathways for Toxic Oil Syndrome

Pathways related to Toxic Oil Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.19 IL5 IL4 IL2RA IGHE IFNG FCER2
2 12.65 IL5 IL4 IL2RA IFNG GSTM1
3
Show member pathways
12.48 IL4 IL2RA IGHE IFNG
4
Show member pathways
12.43 IL5 IL4 IL2RA IFNG AHR
5 12.38 IL4 IL2RA IFNG IDO1
6
Show member pathways
12.22 IL5 IL4 IL2RA IFNG
7
Show member pathways
12.09 IL5 IL4 IL2RA IFNG
8
Show member pathways
11.93 IL5 IL4 IL2RA IFNG
9 11.82 IL4 IGHE FCER2
10 11.82 IL5 IL4 IL2RA IFNG
11
Show member pathways
11.81 IL4 IL2RA IFNG
12 11.69 IL5 IL4 IL2RA FCER2
13 11.64 IL5 IL4 IFNG
14
Show member pathways
11.61 GSTM1 CYP2D6 CYP1A1
15
Show member pathways
11.55 IL5 IL4 IL2RA IFNG
16 11.42 IL5 IL4 IGHE FCER2
17 11.37 IFNG CYP1A1 AHR
18 11.22 IL5 IL4 IL2RA IFNG
19 11.12 IL5 IL4 IFNG
20
Show member pathways
11.1 IL2RA IFNG
21 11.08 IL2RA IFNG
22 11.02 IL5 IL4 IFNG
23 11 GSTM1 CYP1A1
24 10.98 IL5 IL4 IL2RA IFNG
25 10.92 IL5 IL4 IL2RA IFNG AHR
26
Show member pathways
10.8 CYP2D6 CYP1A1
27 10.76 IL5 IL4 IFNG AHR

GO Terms for Toxic Oil Syndrome

Cellular components related to Toxic Oil Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 PNLIP IL5 IL4 IGHE IFNG FCER2

Biological processes related to Toxic Oil Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.55 IL5 IL4 IL2RA IGHE IFNG
2 xenobiotic metabolic process GO:0006805 9.54 NAT2 CYP2D6 AHR
3 positive regulation of interleukin-12 production GO:0032735 9.49 IFNG IDO1
4 drug metabolic process GO:0017144 9.48 CYP2D6 CYP1A1
5 long-chain fatty acid biosynthetic process GO:0042759 9.46 CYP2D6 CYP1A1
6 positive regulation of T cell differentiation GO:0045582 9.43 IL4 IL2RA
7 regulation of regulatory T cell differentiation GO:0045589 9.4 IL2RA IFNG
8 heterocycle metabolic process GO:0046483 9.32 CYP2D6 CYP1A1
9 coumarin metabolic process GO:0009804 9.26 CYP2D6 CYP1A1
10 cytokine-mediated signaling pathway GO:0019221 9.02 IL5 IL4 IL2RA IGHE FCER2
11 positive regulation of killing of cells of other organism GO:0051712 8.96 IFNG FCER2

Molecular functions related to Toxic Oil Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hydroxylase activity GO:0008395 9.26 CYP2D6 CYP1A1
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.16 CYP2D6 CYP1A1
3 aromatase activity GO:0070330 8.96 CYP2D6 CYP1A1
4 heme binding GO:0020037 8.8 IDO1 CYP2D6 CYP1A1

Sources for Toxic Oil Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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