MCID: TXC020
MIFTS: 33

Toxic Oil Syndrome

Categories: Rare diseases

Aliases & Classifications for Toxic Oil Syndrome

MalaCards integrated aliases for Toxic Oil Syndrome:

Name: Toxic Oil Syndrome 58

Characteristics:

Orphanet epidemiological data:

58
toxic oil syndrome
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

UMLS via Orphanet 72 C0409998
Orphanet 58 ORPHA227972

Summaries for Toxic Oil Syndrome

MalaCards based summary : Toxic Oil Syndrome is related to eosinophilia-myalgia syndrome and eosinophilic fasciitis. An important gene associated with Toxic Oil Syndrome is AHR (Aryl Hydrocarbon Receptor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. Affiliated tissues include lung, liver and skin, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Wikipedia : 74 Toxic oil syndrome or simply toxic syndrome (Spanish: síndrome del aceite tóxico or síndrome tóxico) is... more...

Related Diseases for Toxic Oil Syndrome

Diseases related to Toxic Oil Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 eosinophilia-myalgia syndrome 30.4 IL5 IFNG IDO1 AHR
2 eosinophilic fasciitis 30.0 IL5 IFNG AHR
3 hypereosinophilic syndrome 29.6 IL5 IL4 IL2RA IGHE IFNG
4 proteasome-associated autoinflammatory syndrome 1 29.2 IL5 IL4 IFNG
5 autoimmune disease 29.1 IL5 IL4 IL2RA IFNG IDO1
6 skin disease 28.6 IL5 IL4 IFNG FCER2
7 aryl hydrocarbon hydroxylase inducibility 10.5 CYP1A1 AHR
8 systemic scleroderma 10.4
9 acetaminophen metabolism 10.3 CYP2D6 CYP1A1
10 spotted fever rickettsiosis 10.3 IFNG IDO1
11 pulmonary hypertension 10.3
12 staphylococcal toxic shock syndrome 10.2 IGHE IFNG
13 b cell prolymphocytic leukemia 10.2 IL2RA FCER2
14 dendritic cell tumor 10.2 IFNG FCER2
15 fasciitis 10.2
16 persistent polyclonal b-cell lymphocytosis 10.2 IL4 FCER2
17 chronic active epstein-barr virus infection 10.2 IFNG IDO1
18 leukoplakia 10.2 GSTM1 CYP1A1
19 chronic graft versus host disease 10.2 IL2RA IFNG
20 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
21 b-cell growth factor 10.2 IL4 IFNG
22 idiopathic neutropenia 10.2 IL2RA FCER2
23 nut allergy 10.1 IL5 IGHE
24 orofacial granulomatosis 10.1 IL4 IFNG
25 vasculitis 10.1
26 idiopathic nephrotic syndrome 10.1 IL4 IGHE
27 carpal tunnel syndrome 10.1
28 scleroderma, familial progressive 10.1
29 clonorchiasis 10.1 IGHE IFNG
30 eales disease 10.0 IL4 IFNG CP
31 pneumoconiosis 10.0 IL4 GSTM1 CP
32 stevens-johnson syndrome/toxic epidermal necrolysis 10.0 IL5 IFNG
33 tuberculoid leprosy 10.0 IL2RA IFNG
34 fibromuscular dysplasia 10.0
35 hypercholesterolemia, familial, 1 10.0
36 pulmonary hypertension, primary, 1 10.0
37 liver disease 10.0
38 hyperglycemia 10.0
39 muscular atrophy 10.0
40 neuropathy 10.0
41 raynaud phenomenon 10.0
42 mycoplasma pneumoniae pneumonia 10.0 IL4 IFNG CYP1A1
43 paragonimiasis 10.0 IL5 IGHE
44 granulocytopenia 10.0 NAT2 CP
45 extrinsic allergic alveolitis 10.0 IL2RA IGHE FCER2
46 autoimmune disease of gastrointestinal tract 10.0 IL4 IFNG CYP2D6
47 beta-lactam allergy 10.0 IL4 IGHE
48 disseminated eosinophilic collagen disease 10.0 IL5 IL2RA
49 eczema herpeticum 9.9 IL4 IFNG IDO1
50 loiasis 9.9 IL5 IL4

Graphical network of the top 20 diseases related to Toxic Oil Syndrome:



Diseases related to Toxic Oil Syndrome

Symptoms & Phenotypes for Toxic Oil Syndrome

GenomeRNAi Phenotypes related to Toxic Oil Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 AHR GSTM1 IDO1 IL2RA IL5 PNLIP

MGI Mouse Phenotypes related to Toxic Oil Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 AHR CP CYP1A1 FCER2 IDO1 IFNG
2 homeostasis/metabolism MP:0005376 9.9 AHR CP CYP1A1 FCER2 IDO1 IFNG
3 digestive/alimentary MP:0005381 9.87 AHR FCER2 IFNG IL2RA IL4 IL5
4 immune system MP:0005387 9.61 AHR CP CYP1A1 FCER2 IDO1 IFNG
5 liver/biliary system MP:0005370 9.17 AHR CP CYP1A1 IFNG IL4 IL5

Drugs & Therapeutics for Toxic Oil Syndrome

Search Clinical Trials , NIH Clinical Center for Toxic Oil Syndrome

Genetic Tests for Toxic Oil Syndrome

Anatomical Context for Toxic Oil Syndrome

MalaCards organs/tissues related to Toxic Oil Syndrome:

40
Lung, Liver, Skin, Heart, Testes, Bone, T Cells

Publications for Toxic Oil Syndrome

Articles related to Toxic Oil Syndrome:

(show top 50) (show all 317)
# Title Authors PMID Year
1
Influence of long-standing pulmonary arterial hypertension and its severity on pulmonary artery aneurysm development. 61
32248253 2020
2
Should systemic sclerosis be recognised as an occupational disease in Switzerland? 61
32083706 2020
3
[Hypereosinophilic syndrome and other rheumatic diseases with hypereosinophilia]. 61
30937528 2019
4
Peak AAA fatty acid homolog contaminants present in the dietary supplement l-Tryptophan associated with the onset of eosinophilia-myalgia syndrome. 61
29800716 2018
5
C/EBPβ-Thr217 Phosphorylation Stimulates Macrophage Inflammasome Activation and Liver Injury. 61
27067260 2016
6
Human adjuvant-related syndrome or autoimmune/inflammatory syndrome induced by adjuvants. Where have we come from? Where are we going? A proposal for new diagnostic criteria. 61
25813870 2015
7
Morphological clues in the diagnosis of sclerodermiform dermatitis. 61
24423930 2014
8
Diagnosis and classification of eosinophilic fasciitis. 61
24424187 2014
9
Survival in pulmonary hypertension in Spain: insights from the Spanish registry. 61
22362843 2012
10
Severe eosinophilic syndrome associated with the use of probiotic supplements: a new entity? 61
23259129 2012
11
Environmental- and injury-related epidemic-assistance investigations, 1946-2005. 61
22135395 2011
12
Contribution of denaturing and deodorization processes of oils to toxic oil syndrome. 61
21238434 2011
13
Proteomics of toxic oil syndrome in humans: Phenotype distribution in a population of patients. 61
21075095 2011
14
Potential implication of aniline derivatives in the Toxic Oil Syndrome (TOS). 61
20970410 2011
15
[Political change, disease and healthcare reform: the response to the Toxic Oil Syndrome (Spain, 1981-1998)]. 61
22375302 2011
16
Diet in dermatology: revisited. 61
20228538 2010
17
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? 61
19941898 2010
18
[Skin manifestations of toxic syndrome due to denatured rapeseed oil]. 61
20038361 2009
19
[Eosinophilia myalgia syndrome (EMS) caused by L-tryptophan product and toxic oil syndrome (TOS) caused by denatured rape-seed oil]. 61
20065617 2009
20
Effects of toxic oil syndrome on the psychological conditions of the descendants of affected persons. 61
19186503 2008
21
Studies on toxic oil syndrome: development of an enzyme-linked immunosorbent assay for 3-(N-phenylamino)propane-1,2-diol in human urine. 61
18418587 2008
22
High prevalence of cardiovascular risk in patients with toxic oil syndrome: a comparative study using the general Spanish population. 61
18206599 2008
23
Strain-dependent acute lung injury after intra-tracheal administration of a 'refined' aniline-denatured rapeseed oil: a murine model of the toxic oil syndrome? 61
17686560 2007
24
[Current differential diagnosis of hypereosinophilic syndrome]. 61
18666600 2007
25
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome. 61
17892268 2007
26
In vitro bioactivation of 3-(N-phenylamino)propane-1,2-diol by human and rat liver microsomes and recombinant P450 enzymes. Implications for toxic oil syndrome. 61
17672514 2007
27
LC-MS ion maps for the characterization of aniline derivatives of fatty acids and triglycerides in laboratory-denatured rapeseed oil. 61
17295417 2007
28
Endocytosis and intracellular trafficking of fatty acid esters of phenylaminopropanediol, the putative etiologic agents of the toxic oil syndrome (TOS). 61
16343824 2006
29
Proteotyping of human haptoglobin by MALDI-TOF profiling: Phenotype distribution in a population of toxic oil syndrome patients. 61
16544284 2006
30
Drug-, toxin-, and radiation therapy-induced eosinophilic pneumonia. 61
16612770 2006
31
Genetic approaches in the understanding of Toxic Oil Syndrome. 61
16236472 2006
32
[Pulmonary hypertension during exercise in toxic oil syndrome]. 61
16324479 2005
33
Toxic oil syndrome: genetic restriction and immunomodulatory effects due to adulterated oils in a model of HLA transgenic mice. 61
15979827 2005
34
Synthesis and stability studies of the glutathione and N-acetylcysteine adducts of an iminoquinone reactive intermediate generated in the biotransformation of 3-(N-phenylamino)propane-1,2-diol: implications for toxic oil syndrome. 61
16300381 2005
35
Immunotoxic response of oleic acid anilide and its hydrolysis products in female MRL (+/+) mice. 61
18958679 2005
36
[Lung function testing in patients with pulmonary arterial hypertension]. 61
16029731 2005
37
Quality of life, disability and handicap in patients with toxic oil syndrome. 61
15926964 2005
38
On the generation and outcome of 3-(N-phenylamino)propane-1,2-diol derivatives in deodorized model oils related to toxic oil syndrome. 61
15833026 2005
39
Miliary tuberculosis in a patient with eosinophilic fasciitis. 61
15678644 2005
40
Review article toxic oil syndrome: review of immune aspects of the disease. 61
18958659 2005
41
Induction of c-fos messenger RNA by 3-(N-phenylamino)-1,2-propanediol esters, compounds related to Toxic Oil Syndrome. 61
15501433 2004
42
Studies on toxic oil syndrome: stereoselective hydrolysis of 3-(phenylamino)propane-1,2-diol esters by human pancreatic lipase. 61
15257613 2004
43
Spontaneous coronary dissection during postpartum: etiology and controversies in management. 61
15487278 2004
44
The limits of epidemiology and the Spanish Toxic Oil Syndrome. 61
15166211 2004
45
Determination of protein markers in human serum: Analysis of protein expression in toxic oil syndrome studies. 61
14760700 2004
46
[Diagnostic performance of echocardiography in the follow-up of patients with toxic oil syndrome]. 61
14670272 2003
47
[Review of ethical aspects in biomedical research. The experience of the Ethics Committee of the Center for Toxic Oil Syndrome and Rare Diseases [CISATER]]. 61
14670259 2003
48
[Prevalence of cardiovascular risk factors in a cohort of affected by the toxic oil syndrome]. 61
14563269 2003
49
Characteristics of disability and handicap among Toxic Oil Syndrome (TOS) cohort patients: a cross-sectional study, 17 years after the original food intoxication. 61
14534059 2003
50
Neurologic outcomes of toxic oil syndrome patients 18 years after the epidemic. 61
12896854 2003

Variations for Toxic Oil Syndrome

Expression for Toxic Oil Syndrome

Search GEO for disease gene expression data for Toxic Oil Syndrome.

Pathways for Toxic Oil Syndrome

Pathways related to Toxic Oil Syndrome according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.19 IL5 IL4 IL2RA IGHE IFNG FCER2
2 12.65 IL5 IL4 IL2RA IFNG GSTM1
3
Show member pathways
12.48 IL4 IL2RA IGHE IFNG
4
Show member pathways
12.43 IL5 IL4 IL2RA IFNG AHR
5 12.38 IL4 IL2RA IFNG IDO1
6
Show member pathways
12.28 IL5 IL4 IL2RA IFNG
7
Show member pathways
12.09 IL5 IL4 IL2RA IFNG
8 11.83 IL4 IGHE FCER2
9
Show member pathways
11.82 IL4 IL2RA IFNG
10 11.82 IL5 IL4 IL2RA IFNG
11 11.7 IL5 IL4 IL2RA FCER2
12 11.64 IL5 IL4 IFNG
13
Show member pathways
11.61 GSTM1 CYP2D6 CYP1A1
14
Show member pathways
11.55 IL5 IL4 IL2RA IFNG
15 11.42 IL5 IL4 IGHE FCER2
16 11.37 IFNG CYP1A1 AHR
17 11.22 IL5 IL4 IL2RA IFNG
18 11.12 IL5 IL4 IFNG
19 11.02 IL5 IL4 IFNG
20 11 GSTM1 CYP1A1
21 10.98 IL5 IL4 IL2RA IFNG
22 10.92 IL5 IL4 IL2RA IFNG AHR
23
Show member pathways
10.82 CYP2D6 CYP1A1
24 10.76 IL5 IL4 IFNG AHR
25 10.64 IL5 IL4

GO Terms for Toxic Oil Syndrome

Biological processes related to Toxic Oil Syndrome according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.65 IL5 IL4 IL2RA IGHE IFNG
2 xenobiotic metabolic process GO:0006805 9.63 NAT2 CYP2D6 AHR
3 drug metabolic process GO:0017144 9.55 CYP2D6 CYP1A1
4 positive regulation of T cell differentiation GO:0045582 9.54 IL4 IL2RA
5 estrogen metabolic process GO:0008210 9.52 CYP2D6 CYP1A1
6 regulation of regulatory T cell differentiation GO:0045589 9.51 IL2RA IFNG
7 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.49 IFNG FCER2
8 positive regulation of chemokine biosynthetic process GO:0045080 9.48 IL4 IFNG
9 positive regulation of MHC class II biosynthetic process GO:0045348 9.43 IL4 IFNG
10 heterocycle metabolic process GO:0046483 9.4 CYP2D6 CYP1A1
11 coumarin metabolic process GO:0009804 9.37 CYP2D6 CYP1A1
12 positive regulation of killing of cells of other organism GO:0051712 9.32 IFNG FCER2
13 positive regulation of cellular respiration GO:1901857 9.16 IL4 IFNG
14 cytokine-mediated signaling pathway GO:0019221 9.02 IL5 IL4 IL2RA IGHE FCER2
15 neuroinflammatory response GO:0150076 8.96 IL4 IFNG

Molecular functions related to Toxic Oil Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.8 IDO1 CYP2D6 CYP1A1

Sources for Toxic Oil Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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