MCID: TXC008
MIFTS: 27

Toxic Optic Neuropathy

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Toxic Optic Neuropathy

MalaCards integrated aliases for Toxic Optic Neuropathy:

Name: Toxic Optic Neuropathy 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13329
ICD10 33 H46.3
ICD9CM 35 377.34
SNOMED-CT 68 26125006
UMLS 73 C0155303

Summaries for Toxic Optic Neuropathy

MalaCards based summary : Toxic Optic Neuropathy is related to optic nerve disease and neuropathy. An important gene associated with Toxic Optic Neuropathy is RGL1 (Ral Guanine Nucleotide Dissociation Stimulator Like 1), and among its related pathways/superpathways are Salmonella infection (KEGG) and Bacterial invasion of epithelial cells. Affiliated tissues include eye, prostate and bone, and related phenotype is Increased shRNA abundance.

Related Diseases for Toxic Optic Neuropathy

Diseases related to Toxic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 optic nerve disease 10.7
2 neuropathy 10.7
3 iritis 10.0 EPO MRAP
4 microcytic anemia 10.0 CAT EPO
5 palindromic rheumatism 10.0 IL1B MRAP
6 poems syndrome 10.0 EPO IL1B
7 pneumoconiosis 10.0 CAT IL1B
8 bone inflammation disease 9.9 IL1B MRAP
9 suppression of tumorigenicity 12 9.8
10 adenocarcinoma 9.8
11 scotoma 9.8
12 acquired immunodeficiency syndrome 9.8 EPO IL1B

Graphical network of the top 20 diseases related to Toxic Optic Neuropathy:



Diseases related to Toxic Optic Neuropathy

Symptoms & Phenotypes for Toxic Optic Neuropathy

GenomeRNAi Phenotypes related to Toxic Optic Neuropathy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 CAT EPO SEPT2

Drugs & Therapeutics for Toxic Optic Neuropathy

Search Clinical Trials , NIH Clinical Center for Toxic Optic Neuropathy

Genetic Tests for Toxic Optic Neuropathy

Anatomical Context for Toxic Optic Neuropathy

MalaCards organs/tissues related to Toxic Optic Neuropathy:

41
Eye, Prostate, Bone

Publications for Toxic Optic Neuropathy

Articles related to Toxic Optic Neuropathy:

(show all 43)
# Title Authors Year
1
Protective effects of Rutin against methanol induced acute toxic optic neuropathy: an experimental study. ( 29862175 )
2018
2
Central scotoma in tobacco-alcohol toxic optic neuropathy measured with semi-automated kinetic perimetry. ( 29688089 )
2018
3
Occupational exposure to unburnt tobacco and potential risk of toxic optic neuropathy: A cross-sectional study among beedi rollers in selected rural areas of coastal Karnataka, India. ( 29149211 )
2017
4
Erythropoietin as an adjunctive treatment for methanol-induced toxic optic neuropathy. ( 27463192 )
2016
5
Re-Treatment With Ethambutol After Toxic Optic Neuropathy. ( 27636749 )
2016
6
Incidence of toxic optic neuropathy with low-dose ethambutol. ( 26792482 )
2016
7
Methanol-induced toxic optic neuropathy with diffusion weighted MRI findings. ( 26820508 )
2016
8
Docetaxel-Related Toxic Optic Neuropathy in Management of Prostate Adenocarcinoma. ( 27527400 )
2016
9
Ethambutol/Linezolid Toxic Optic Neuropathy. ( 26636399 )
2016
10
Determination of potential role of antioxidative status and circulating biochemical markers in the pathogenesis of ethambutol induced toxic optic neuropathy among diabetic and non-diabetic patients. ( 26587002 )
2015
11
Toxic optic neuropathy: an unusual cause. ( 25449946 )
2014
12
A rare case of toxic optic neuropathy secondary to consumption of neem oil. ( 24722271 )
2014
13
Toxic optic neuropathy in the setting of docetaxel chemotherapy: a case report. ( 24564293 )
2014
14
Ethambutol induced toxic optic neuropathy in HIV positive patients. ( 23991394 )
2013
15
A rare case of toxic optic neuropathy secondary to consumption of neem oil. ( 24212206 )
2013
16
Toxic optic neuropathy following ingestion of homeopathic medication Arnica-30. ( 22877081 )
2013
17
How should the ophthalmologists treat the methanol-induced toxic optic neuropathy? ( 22864052 )
2012
18
What are the therapeutic effects of high-dose intravenous prednisolone in methanol-induced toxic optic neuropathy? ( 22304617 )
2012
19
Hooch blindness: a community study report on a few indoor patients of toxic optic neuropathy following consumption of adulterated alcohol in West Bengal. ( 22344014 )
2012
20
Severe acute bilateral alcohol-induced toxic optic neuropathy--case report. ( 23373403 )
2012
21
Toxic optic neuropathy. ( 22446922 )
2012
22
Toxic optic neuropathy. ( 21350283 )
2011
23
Therapeutic effects of high-dose intravenous prednisolone in methanol-induced toxic optic neuropathy. ( 21663445 )
2011
24
Evaluation of retinal nerve fiber layer thickness measurements using optical coherence tomography in patients with tobacco-alcohol-induced toxic optic neuropathy. ( 20952853 )
2010
25
Evaluation of retinal nerve fiber layer thickness measurements using optical coherence tomography in patients with tobacco-alcohol-induced toxic optic neuropathy. ( 20195038 )
2010
26
Serial retinal nerve fiber layer changes in patients with toxic optic neuropathy associated with antituberculosis pharmacotherapy. ( 20028260 )
2009
27
Ciprofloxacin-induced toxic optic neuropathy. ( 17300586 )
2007
28
Linezolid-associated toxic optic neuropathy. ( 16505322 )
2006
29
Linezolid induced toxic optic neuropathy. ( 16299156 )
2005
30
Linezolid-associated toxic optic neuropathy: a report of 2 cases. ( 14583875 )
2003
31
Toxic optic neuropathy. ( 12914684 )
2003
32
Bilateral anterior toxic optic neuropathy and the use of infliximab. ( 12637403 )
2003
33
Pattern visual evoked cortical potentials in patients with toxic optic neuropathy caused by toluene abuse. ( 10580669 )
1999
34
Toxic optic neuropathy after concomitant use of melatonin, zoloft, and a high-protein diet. ( 10608673 )
1999
35
Toxic optic neuropathy associated with ethambutol: implications for current therapy. ( 8071504 )
1994
36
Visual functions and trace element metabolism in tobacco-toxic optic neuropathy. ( 1303871 )
1992
37
Corticosteroid-induced toxic optic neuropathy. ( 1951609 )
1991
38
Serial pattern evoked potential recording in a case of toxic optic neuropathy due to ethambutol. ( 2449333 )
1988
39
Use of contrast sensitivity measurement in the detection of subclinical ethambutol toxic optic neuropathy. ( 3828274 )
1987
40
Recurrent acute toxic optic neuropathy secondary to 5-FU. ( 6704988 )
1984
41
Toxic optic neuropathy caused by benoxaprofen. ( 6789963 )
1981
42
Toxic optic neuropathy and its experimental production. ( 1071911 )
1976
43
Biochemical observations in toxic optic neuropathy. ( 5283437 )
1970

Variations for Toxic Optic Neuropathy

Expression for Toxic Optic Neuropathy

Search GEO for disease gene expression data for Toxic Optic Neuropathy.

Pathways for Toxic Optic Neuropathy

Pathways related to Toxic Optic Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.19 IL1B WAS
2 11.02 SEPT2 WAS
3 10.64 EPO IL1B
4 10.05 EPO RGL1

GO Terms for Toxic Optic Neuropathy

Cellular components related to Toxic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CAT EPO IL18BP IL1B SERPINB1
2 extracellular exosome GO:0070062 9.1 CAT IL18BP IL1B SEPT2 SERPINB1 WAS

Biological processes related to Toxic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.58 CAT EPO IL1B
2 response to lipopolysaccharide GO:0032496 9.54 EPO IL18BP IL1B
3 positive regulation of cell division GO:0051781 9.46 CAT IL1B
4 embryo implantation GO:0007566 9.43 EPO IL1B
5 response to vitamin A GO:0033189 9.32 CAT EPO
6 response to hyperoxia GO:0055093 9.26 CAT EPO
7 response to dexamethasone GO:0071548 9.16 EPO IL1B
8 response to L-ascorbic acid GO:0033591 8.96 CAT IL1B
9 response to ozone GO:0010193 8.62 CAT IL1B

Sources for Toxic Optic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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