MCID: TXC008
MIFTS: 26

Toxic Optic Neuropathy

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Toxic Optic Neuropathy

MalaCards integrated aliases for Toxic Optic Neuropathy:

Name: Toxic Optic Neuropathy 12 44 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:13329
ICD9CM 34 377.34
MeSH 44 D000081028
SNOMED-CT 67 194053003
ICD10 32 H46.3
UMLS 70 C0155303

Summaries for Toxic Optic Neuropathy

MalaCards based summary : Toxic Optic Neuropathy is related to neuropathy and nutritional optic neuropathy. An important gene associated with Toxic Optic Neuropathy is RGL1 (Ral Guanine Nucleotide Dissociation Stimulator Like 1), and among its related pathways/superpathways is Prion disease. Affiliated tissues include retina and prostate, and related phenotype is cardiovascular system.

Related Diseases for Toxic Optic Neuropathy

Diseases related to Toxic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 neuropathy 30.2 TMEM126A SLC25A4 MT-ND6 MT-ND4 MFN2
2 nutritional optic neuropathy 29.8 RGL1 OPA3 AQP4
3 optic nerve disease 29.8 TMEM126A OPA3 MT-ND6 MT-ND4 MFN2 AQP4
4 optic neuritis 29.5 MT-ND6 MT-ND4 AQP4
5 scotoma 29.3 TMEM126A OPA3 MT-ND6 MT-ND4 AQP4
6 peripheral nervous system disease 29.1 OPA3 MT-ND6 MT-ND4 MFN2 AQP4
7 3-methylglutaconic aciduria, type iii 28.9 TMEM126A SLC25A4 OPA3 MT-ND6 MT-ND4 MFN2
8 color blindness 10.2
9 alcohol dependence 10.2
10 yemenite deaf-blind hypopigmentation syndrome 10.2
11 suppression amblyopia 10.2
12 amblyopia 10.2
13 optic atrophy 6 10.2 TMEM126A OPA3
14 optic atrophy 8 10.2 TMEM126A OPA3
15 optic atrophy 2 10.1 TMEM126A OPA3
16 tritanopia 10.1 TMEM126A OPA3
17 alcohol use disorder 10.1
18 methanol poisoning 10.1
19 wolfram syndrome 10.0 TMEM126A OPA3
20 acute retrobulbar neuritis 10.0 MT-ND4 AQP4
21 hereditary optic neuropathy 10.0 MT-ND6 MT-ND4
22 combined oxidative phosphorylation deficiency 7 10.0 MFN2 AQP4
23 mitochondrial dna-associated leigh syndrome 10.0 MT-ND6 MT-ND4
24 mitochondrial dna-associated leigh syndrome and narp 10.0 MT-ND6 MT-ND4
25 skin amelanotic melanoma 9.9 MFN2 AQP4
26 drug-induced hearing loss 9.9 MT-ND6 MT-ND4
27 ocular motor apraxia 9.9
28 suppression of tumorigenicity 12 9.9
29 osteomyelitis 9.9
30 partial optic atrophy 9.9
31 myopia 9.9
32 hypothyroidism 9.9
33 papilledema 9.9
34 neuritis 9.9
35 macrocytic anemia 9.9
36 adenocarcinoma 9.9
37 lung disease 9.9
38 47,xyy 9.9
39 posttransplant acute limbic encephalitis 9.9
40 leber optic atrophy and dystonia 9.9 MT-ND6 MT-ND4
41 pearson marrow-pancreas syndrome 9.9 MT-ND6 MT-ND4
42 neuropathy, hereditary motor and sensory, type via, with optic atrophy 9.9 TMEM126A OPA3 MFN2
43 behr syndrome 9.9 TMEM126A OPA3 MFN2
44 neuropathy, ataxia, and retinitis pigmentosa 9.9 MT-ND6 MT-ND4
45 optic atrophy 3, autosomal dominant 9.9 TMEM126A OPA3 MFN2
46 deafness, aminoglycoside-induced 9.9 MT-ND6 MT-ND4
47 cortical blindness 9.9 MT-ND6 MT-ND4
48 myoclonic epilepsy associated with ragged-red fibers 9.8 MT-ND6 MT-ND4
49 mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes 9.8 MT-ND6 MT-ND4
50 mitochondrial metabolism disease 9.8 SLC25A4 MT-ND6 MT-ND4

Graphical network of the top 20 diseases related to Toxic Optic Neuropathy:



Diseases related to Toxic Optic Neuropathy

Symptoms & Phenotypes for Toxic Optic Neuropathy

MGI Mouse Phenotypes related to Toxic Optic Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 AQP4 MFN2 MT-ND6 OPA3 RGL1 SLC25A4

Drugs & Therapeutics for Toxic Optic Neuropathy

Search Clinical Trials , NIH Clinical Center for Toxic Optic Neuropathy

Cochrane evidence based reviews: toxic optic neuropathy

Genetic Tests for Toxic Optic Neuropathy

Anatomical Context for Toxic Optic Neuropathy

MalaCards organs/tissues related to Toxic Optic Neuropathy:

40
Retina, Prostate

Publications for Toxic Optic Neuropathy

Articles related to Toxic Optic Neuropathy:

(show top 50) (show all 118)
# Title Authors PMID Year
1
Optic neuropathy by ethambutol in a patient with multiple sclerosis. 61
33632567 2021
2
Ethambutol Optic Neuropathy: Vigilance and Screening, the Keys to Prevent Blindness with the Revised Anti-tuberculous Therapy Regimen. 61
33527812 2021
3
OCULAR ANATOMY AND PATHOLOGY IN LUMHOLTZ'S TREE-KANGAROO (DENDROLAGUS LUMHOLTZI). 61
33480567 2021
4
A case of reversible toxic optic neuropathy from tacrolimus (FK506). 61
33005819 2020
5
Late-stage sequela of an isolated optic neuropathy after acute magnesium valproate overdose: A case report. 61
33222509 2020
6
Choroidal Neovascularization and Toxic Optic Neuropathy Secondary to Tobacco Use: A Case Report. 61
33335822 2020
7
Effects of adenosine triphosphate on methanol-induced experimental optic nerve damage in rats: biochemical and histopathological evaluation. 61
32543996 2020
8
Case Report: Long-term Structural and Functional Effects of Ethambutol Optic Neuropathy. 61
32833400 2020
9
Case Report: Nutritional and Toxic Optic Neuropathy: A Diagnostic Dilemma. 61
32697552 2020
10
Prospective study to evaluate incidence and indicators for early detection of ethambutol toxicity. 61
32713840 2020
11
Toxic Optic Neuropathy From Quinine Overdose. 61
31842144 2020
12
Toxic Optic Neuropathy: A Rare but Serious Side Effect of Chloramphenicol and Ciprofloxacin. 61
32606561 2020
13
Cobalt toxic optic neuropathy and retinopathy: Case report and review of the literature. 61
32025592 2020
14
Linezolid-induced photoreceptor dysfunction masquerading as autoimmune retinopathy. 61
31587118 2020
15
Methanol outbreak: a Malaysian tertiary hospital experience. 61
32028888 2020
16
[Drug-induced toxic optic neuropathy]. 61
32779471 2020
17
[Structural and functional changes in the retina and optic nerve in patients with toxic optic neuropathy caused by acute methanol poisoning]. 61
32880146 2020
18
Different damage patterns of retinal nerve fiber layer and ganglion cell-inner plexiform layer between early glaucoma and non-glaucomatous optic neuropathy. 61
32566499 2020
19
[Amiodarone-induced optic neuropathy: A rare side effect]. 61
31561935 2019
20
Tobacco-Alcohol Toxic Optic Neuropathy. 61
31915743 2019
21
Predicting visual function after an ocular bee sting. 61
30105490 2019
22
Ethambutol-induced optic neuropathy in renal disorder: a clinico-electrophysiological study. 61
31109468 2019
23
The effects of lutein on optic nerve injury induced by ethambutol and isoniazid: an experimental study. 61
30362367 2019
24
Baseline demographics, clinical features, and treatment protocols of 240 patients with optic neuropathy: experiences from a neuro-ophthalmological clinic in the Aegean region of Turkey. 61
29260500 2019
25
Central scotoma in tobacco-alcohol toxic optic neuropathy measured with semi-automated kinetic perimetry. 61
29688089 2018
26
Drug-induced optic neuropathy in a case of extensively drug-resistant pulmonary tuberculosis. 61
30173204 2018
27
The Superoxide Dismutase Mimetic TEMPOL and Its Effect on Retinal Ganglion Cells in Experimental Methanol-Intoxicated Rats. 61
29797209 2018
28
Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still's disease. 61
29472362 2018
29
Tacrolimus Optic Neuropathy. 61
29420328 2018
30
Case Report: Linezolid Optic Neuropathy and Proposed Evidenced-based Screening Recommendation. 61
29683987 2018
31
Bilateral vision loss due to Leber's hereditary optic neuropathy after long-term alcohol, nicotine and drug abuse. 61
29372350 2018
32
Protective effects of Rutin against methanol induced acute toxic optic neuropathy: an experimental study. 61
29862175 2018
33
Re-Treatment With Ethambutol After Toxic Optic Neuropathy. 61
27636749 2017
34
Docetaxel-Related Toxic Optic Neuropathy in Management of Prostate Adenocarcinoma. 61
27527400 2017
35
Optical coherence tomography findings in methanol toxicity. 61
29021915 2017
36
Short-term treatment with oral amiodarone resulting in bilateral optic neuropathy and permanent blindness. 61
28069784 2017
37
Occupational exposure to unburnt tobacco and potential risk of toxic optic neuropathy: A cross-sectional study among beedi rollers in selected rural areas of coastal Karnataka, India. 61
29149211 2017
38
Cobalt-Chromium Metallosis With Normal Electroretinogram. 61
27295601 2016
39
Methanol-induced toxic optic neuropathy with diffusion weighted MRI findings. 61
26820508 2016
40
Erythropoietin as an adjunctive treatment for methanol-induced toxic optic neuropathy. 61
27463192 2016
41
A case of retrobulbar optic neuritis caused by duloxetine. 61
26362493 2016
42
Ethambutol/Linezolid Toxic Optic Neuropathy. 61
26636399 2016
43
Incidence of toxic optic neuropathy with low-dose ethambutol. 61
26792482 2016
44
Determination of potential role of antioxidative status and circulating biochemical markers in the pathogenesis of ethambutol induced toxic optic neuropathy among diabetic and non-diabetic patients. 61
26587002 2015
45
Retinal Ganglion Cell Layer Analysis by Optical Coherence Tomography in Toxic and Nutritional Optic Neuropathy. 61
25724010 2015
46
Toxic optic neuropathies: an updated review. 61
25159832 2015
47
[Severe linezolid-induced toxic optic neuropathy]. 61
25637235 2015
48
Toxic optic neuropathy: an unusual cause. 61
25449946 2014
49
Linezolid-induced optic neuropathy. 61
24088636 2014
50
A rare case of toxic optic neuropathy secondary to consumption of neem oil. 61
24722271 2014

Variations for Toxic Optic Neuropathy

Expression for Toxic Optic Neuropathy

Search GEO for disease gene expression data for Toxic Optic Neuropathy.

Pathways for Toxic Optic Neuropathy

Pathways related to Toxic Optic Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.64 SLC25A4 MT-ND6 MT-ND4 MFN2

GO Terms for Toxic Optic Neuropathy

Cellular components related to Toxic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.26 TMEM126A SLC25A4 MT-ND6 MT-ND4
2 respiratory chain GO:0070469 9.16 MT-ND6 MT-ND4
3 mitochondrion GO:0005739 9.1 TMEM126A SLC25A4 OPA3 MT-ND6 MT-ND4 MFN2

Biological processes related to Toxic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of lipid metabolic process GO:0019216 9.26 RGL1 OPA3
2 mitochondrial electron transport, NADH to ubiquinone GO:0006120 9.16 MT-ND6 MT-ND4
3 response to nicotine GO:0035094 8.96 MT-ND6 MT-ND4
4 mitochondrial respiratory chain complex I assembly GO:0032981 8.8 TMEM126A MT-ND6 MT-ND4

Molecular functions related to Toxic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADH dehydrogenase (ubiquinone) activity GO:0008137 8.62 MT-ND6 MT-ND4

Sources for Toxic Optic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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