MCID: TXC008
MIFTS: 25

Toxic Optic Neuropathy

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Toxic Optic Neuropathy

MalaCards integrated aliases for Toxic Optic Neuropathy:

Name: Toxic Optic Neuropathy 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:13329
ICD9CM 35 377.34
SNOMED-CT 68 26125006
ICD10 33 H46.3
UMLS 72 C0155303

Summaries for Toxic Optic Neuropathy

MalaCards based summary : Toxic Optic Neuropathy is related to optic nerve disease and nutritional optic neuropathy. An important gene associated with Toxic Optic Neuropathy is RGL1 (Ral Guanine Nucleotide Dissociation Stimulator Like 1). Affiliated tissues include prostate and breast, and related phenotype is homeostasis/metabolism.

Related Diseases for Toxic Optic Neuropathy

Graphical network of the top 20 diseases related to Toxic Optic Neuropathy:



Diseases related to Toxic Optic Neuropathy

Symptoms & Phenotypes for Toxic Optic Neuropathy

MGI Mouse Phenotypes related to Toxic Optic Neuropathy:

46 (showing 1, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 CAT EHD4 IL18BP IL1B MBP MFN2

Drugs & Therapeutics for Toxic Optic Neuropathy

Search Clinical Trials , NIH Clinical Center for Toxic Optic Neuropathy

Genetic Tests for Toxic Optic Neuropathy

Anatomical Context for Toxic Optic Neuropathy

MalaCards organs/tissues related to Toxic Optic Neuropathy:

41
Prostate, Breast

Publications for Toxic Optic Neuropathy

Articles related to Toxic Optic Neuropathy:

(showing 98, show less)
# Title Authors PMID Year
1
Predicting visual function after an ocular bee sting. 38
30105490 2019
2
The effects of lutein on optic nerve injury induced by ethambutol and isoniazid: an experimental study. 38
30362367 2019
3
Ethambutol-induced optic neuropathy in renal disorder: a clinico-electrophysiological study. 38
31109468 2019
4
Baseline demographics, clinical features, and treatment protocols of 240 patients with optic neuropathy: experiences from a neuro-ophthalmological clinic in the Aegean region of Turkey. 38
29260500 2019
5
Drug-induced optic neuropathy in a case of extensively drug-resistant pulmonary tuberculosis. 38
30173204 2018
6
Central scotoma in tobacco-alcohol toxic optic neuropathy measured with semi-automated kinetic perimetry. 38
29688089 2018
7
The Superoxide Dismutase Mimetic TEMPOL and Its Effect on Retinal Ganglion Cells in Experimental Methanol-Intoxicated Rats. 38
29797209 2018
8
Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still's disease. 38
29472362 2018
9
Tacrolimus Optic Neuropathy. 38
29420328 2018
10
Case Report: Linezolid Optic Neuropathy and Proposed Evidenced-based Screening Recommendation. 38
29683987 2018
11
Bilateral vision loss due to Leber's hereditary optic neuropathy after long-term alcohol, nicotine and drug abuse. 38
29372350 2018
12
Protective effects of Rutin against methanol induced acute toxic optic neuropathy: an experimental study. 38
29862175 2018
13
Re-Treatment With Ethambutol After Toxic Optic Neuropathy. 38
27636749 2017
14
Docetaxel-Related Toxic Optic Neuropathy in Management of Prostate Adenocarcinoma. 38
27527400 2017
15
Short-term treatment with oral amiodarone resulting in bilateral optic neuropathy and permanent blindness. 38
28069784 2017
16
Occupational exposure to unburnt tobacco and potential risk of toxic optic neuropathy: A cross-sectional study among beedi rollers in selected rural areas of coastal Karnataka, India. 38
29149211 2017
17
Optical coherence tomography findings in methanol toxicity. 38
29021915 2017
18
Cobalt-Chromium Metallosis With Normal Electroretinogram. 38
27295601 2016
19
Methanol-induced toxic optic neuropathy with diffusion weighted MRI findings. 38
26820508 2016
20
Erythropoietin as an adjunctive treatment for methanol-induced toxic optic neuropathy. 38
27463192 2016
21
A case of retrobulbar optic neuritis caused by duloxetine. 38
26362493 2016
22
Incidence of toxic optic neuropathy with low-dose ethambutol. 38
26792482 2016
23
Ethambutol/Linezolid Toxic Optic Neuropathy. 38
26636399 2016
24
Determination of potential role of antioxidative status and circulating biochemical markers in the pathogenesis of ethambutol induced toxic optic neuropathy among diabetic and non-diabetic patients. 38
26587002 2015
25
Retinal Ganglion Cell Layer Analysis by Optical Coherence Tomography in Toxic and Nutritional Optic Neuropathy. 38
25724010 2015
26
Toxic optic neuropathies: an updated review. 38
25159832 2015
27
[Severe linezolid-induced toxic optic neuropathy]. 38
25637235 2015
28
Toxic optic neuropathy: an unusual cause. 38
25449946 2014
29
Linezolid-induced optic neuropathy. 38
24088636 2014
30
A rare case of toxic optic neuropathy secondary to consumption of neem oil. 38
24722271 2014
31
Toxic optic neuropathy in the setting of docetaxel chemotherapy: a case report. 38
24564293 2014
32
Optic Atrophy Secondary to Preseptal Cutaneous Anthrax: Case Report. 38
27928303 2014
33
[Bitemporal hemianopia as presenting sign of severe ethambutol toxicity]. 38
24094504 2013
34
Toxic optic neuropathies. 38
24100370 2013
35
Bilateral optic neuropathy and permanent loss of vision after treatment with amiodarone. 38
23921312 2013
36
Toxic optic neuropathy following ingestion of homeopathic medication Arnica-30. 38
22877081 2013
37
Ethambutol induced toxic optic neuropathy in HIV positive patients. 38
23991394 2013
38
Severe visual loss in a breast cancer patient on chemotherapy. 38
22354765 2012
39
What are the therapeutic effects of high-dose intravenous prednisolone in methanol-induced toxic optic neuropathy? 38
22304617 2012
40
How should the ophthalmologists treat the methanol-induced toxic optic neuropathy? 38
22864052 2012
41
Toxic optic neuropathy. 38
22446922 2012
42
Severe acute bilateral alcohol-induced toxic optic neuropathy--case report. 38
23373403 2012
43
Hooch blindness: a community study report on a few indoor patients of toxic optic neuropathy following consumption of adulterated alcohol in West Bengal. 38
22344014 2012
44
Methanol poisoning: two case studies of blindness in Indonesia. 38
22200859 2011
45
Prognosis of corneal wasp sting: case report and review of the literature. 38
21612321 2011
46
[Reversible optic neuropathy related to disulfiram]. 38
21507508 2011
47
Therapeutic effects of high-dose intravenous prednisolone in methanol-induced toxic optic neuropathy. 38
21663445 2011
48
Toxic optic neuropathy. 38
21350283 2011
49
Visual fields in neuro-ophthalmology. 38
21350279 2011
50
Outcomes of visual disturbances after methanol poisoning. 38
21370946 2011
51
Evaluation of retinal nerve fiber layer thickness measurements using optical coherence tomography in patients with tobacco-alcohol-induced toxic optic neuropathy. 38
20952853 2010
52
[Clinical case of the month. Bilateral optic neuropathy secondary to biphosphonate therapy]. 38
20857699 2010
53
Evaluation of retinal nerve fiber layer thickness measurements using optical coherence tomography in patients with tobacco-alcohol-induced toxic optic neuropathy. 38
20195038 2010
54
Optical coherence tomography findings in deferasirox-related maculopathy. 38
25390664 2010
55
Serial retinal nerve fiber layer changes in patients with toxic optic neuropathy associated with antituberculosis pharmacotherapy. 38
20028260 2009
56
Early stage ethambutol optic neuropathy: retinal nerve fiber layer and optical coherence tomography. 38
19396796 2009
57
Drug-induced optic neuropathies. 38
18174968 2007
58
Absence of bilateral vision loss from amiodarone: a randomized trial. 38
17452162 2007
59
Ciprofloxacin-induced toxic optic neuropathy. 38
17300586 2007
60
Optic neuropathy related to hydrogen peroxide inhalation. 38
17272972 2007
61
Visual field changes in methotrexate therapy. Case report and review of the literature. 38
17190135 2006
62
Ethambutol-associated optic neuropathy. 38
16710500 2006
63
Linezolid-associated toxic optic neuropathy. 38
16505322 2006
64
Linezolid induced toxic optic neuropathy. 38
16299156 2005
65
Corneal honeybee sting. 38
16116512 2005
66
Optical coherence tomography can measure axonal loss in patients with ethambutol-induced optic neuropathy. 38
15565293 2005
67
[Toxic optic neuropathy due to cisplatin therapy: a case report]. 38
15785991 2005
68
Optic neuropathy associated with linezolid treatment. 38
15756127 2005
69
Optic neuropathies caused by toxins and adverse drug reactions. 38
15337202 2004
70
Linezolid-associated toxic optic neuropathy: a report of 2 cases. 38
14583875 2003
71
Toxic optic neuropathy. 38
12914684 2003
72
Bilateral anterior toxic optic neuropathy and the use of infliximab. 38
12637403 2003
73
Chiasmopathy? 38
10667439 2000
74
Toxic optic neuropathy after concomitant use of melatonin, zoloft, and a high-protein diet. 38
10608673 1999
75
Pattern visual evoked cortical potentials in patients with toxic optic neuropathy caused by toluene abuse. 38
10580669 1999
76
[Toxic optic neuropathy caused by methanol poisoning]. 38
10911425 1998
77
Carbon monoxide poisoning causes optic neuropathy. 38
10070515 1998
78
[Optic nerve damage caused by administration of ethambutol]. 38
9531761 1997
79
[Severe toxic optic neuropathies caused by isoniazid. Apropos of 3 cases]. 38
7759756 1995
80
[Optic neuropathy caused by alcoholism and smoking: a diagnostic pitfall of Leber's optic neuropathy]. 38
7597375 1994
81
Toxic optic neuropathy associated with ethambutol: implications for current therapy. 38
8071504 1994
82
Ophthalmologic features of thallium poisoning. 38
8116754 1994
83
Visual functions and trace element metabolism in tobacco-toxic optic neuropathy. 38
1303871 1992
84
[Bilateral optic neuropathy with papilledema]. 38
1583843 1992
85
Corticosteroid-induced toxic optic neuropathy. 38
1951609 1991
86
[The therapeutic approach in optic neuropathy due to methyl alcohol]. 38
1811735 1991
87
A review of the clinical applications of the pattern electroretinogram. 38
2695880 1989
88
[Arteriosclerotic ischemic optic neuropathy. Current findings in the diagnosis and etiopathogenesis of the disease]. 38
2527390 1989
89
Bilateral optic neuropathy associated with amiodarone therapy. 38
2972746 1988
90
Serial pattern evoked potential recording in a case of toxic optic neuropathy due to ethambutol. 38
2449333 1988
91
Use of contrast sensitivity measurement in the detection of subclinical ethambutol toxic optic neuropathy. 38
3828274 1987
92
Recurrent acute toxic optic neuropathy secondary to 5-FU. 38
6704988 1984
93
Chlorpropamide-induced optic neuropathy. 38
7059267 1982
94
Toxic optic neuropathy caused by benoxaprofen. 38
6789963 1981
95
Unilateral optic neuropathy following vincristine chemotherapy. 38
287774 1979
96
Serum cobalamin and folate in the optic neuropathy associated with tobacco smoking. 38
647462 1978
97
Toxic optic neuropathy and its experimental production. 38
1071911 1976
98
Biochemical observations in toxic optic neuropathy. 38
5283437 1970

Variations for Toxic Optic Neuropathy

Expression for Toxic Optic Neuropathy

Search GEO for disease gene expression data for Toxic Optic Neuropathy.

Pathways for Toxic Optic Neuropathy

GO Terms for Toxic Optic Neuropathy

Cellular components related to Toxic Optic Neuropathy according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.1 WAS SERPINB1 IL1B IL18BP EHD4 CAT

Biological processes related to Toxic Optic Neuropathy according to GeneCards Suite gene sharing:

(showing 8, show less)
# Name GO ID Score Top Affiliating Genes
1 cellular response to growth factor stimulus GO:0071363 9.43 EHD4 CAT
2 positive regulation of cell division GO:0051781 9.4 IL1B CAT
3 aerobic respiration GO:0009060 9.37 MT-ND4 CAT
4 response to hypoxia GO:0001666 9.32 MT-ND4 CAT
5 positive regulation of interleukin-6 secretion GO:2000778 9.26 MBP IL1B
6 response to ethanol GO:0045471 9.16 MT-ND4 CAT
7 response to ozone GO:0010193 8.65 CAT
8 response to L-ascorbic acid GO:0033591 8.32 CAT

Sources for Toxic Optic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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