MCID: TXC007
MIFTS: 28

Toxic Pneumonitis

Categories: Respiratory diseases

Aliases & Classifications for Toxic Pneumonitis

MalaCards integrated aliases for Toxic Pneumonitis:

Name: Toxic Pneumonitis 12 15 73
Acute Pulmonary Edema Due to Fumes and/or Vapors 73
Acute Chemical Fume Pulmonary Edema 12
Acute Chemical Pulmonary Edema 12

Classifications:



External Ids:

Disease Ontology 12 DOID:551
ICD9CM 35 506.9

Summaries for Toxic Pneumonitis

Disease Ontology : 12 A pneumonia that is an acute inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors. It is a sentinel health event (occupational) associated with exposure to ammonia (refrigeration, fertilizer, and oil refining industries), chlorine (alkali and bleach industries), nitrogen oxides (silo fillers, arc welders, and nitric acid industry), sulfur dioxide (paper, refrigeration, and oil refining industries), cadmium (processors and cadmium smelters), trimellitic anhydride (plastics and organic chemical synthesis), and vanadium pentoxide (boilermakers). The two types of pulmonary agents are central and peripheral. Central pulmonary agents, for example, ammonia, are water soluble irritants that injure the upper airways. Peripheral pulmonary agents, for example, phosgene, NOx, and PFIB, are slightly water soluble irritants that injure the alveolar-capillary membranes. Chlorine has both central and peripheral effects.

MalaCards based summary : Toxic Pneumonitis, also known as acute pulmonary edema due to fumes and/or vapors, is related to pulmonary disease, chronic obstructive and aspiration pneumonitis. An important gene associated with Toxic Pneumonitis is LBP (Lipopolysaccharide Binding Protein), and among its related pathways/superpathways are Tuberculosis and Bacterial infections in CF airways. The drugs Histamine and Ranitidine have been mentioned in the context of this disorder. Affiliated tissues include lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Toxic Pneumonitis

Graphical network of the top 20 diseases related to Toxic Pneumonitis:



Diseases related to Toxic Pneumonitis

Symptoms & Phenotypes for Toxic Pneumonitis

GenomeRNAi Phenotypes related to Toxic Pneumonitis according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.64 SCGB1A1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.64 SCGB1A1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.64 LBP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.64 LBP
5 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.64 SFTPB
6 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.64 SFTPB
7 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.64 LBP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.64 SCGB1A1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.64 SCGB1A1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.64 LBP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.64 LBP
12 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.64 SFTPB
13 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.64 SCGB1A1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.64 LBP
15 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.64 LBP
16 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.64 LBP
17 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 SCGB1A1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.64 LBP
19 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.64 LBP SCGB1A1 SFTPB

MGI Mouse Phenotypes related to Toxic Pneumonitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.35 ANO1 LBP SCGB1A1 SFTPB TLR4
2 respiratory system MP:0005388 8.92 ANO1 SCGB1A1 SFTPB TLR4

Drugs & Therapeutics for Toxic Pneumonitis

Drugs for Toxic Pneumonitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Not Applicable 51-45-6, 75614-87-8 774
2
Ranitidine Approved Not Applicable 66357-35-5, 66357-59-3 3001055
3
Citric Acid Approved, Nutraceutical, Vet_approved Not Applicable 77-92-9 311
4 Anti-Ulcer Agents Not Applicable
5 Citrate Not Applicable
6
Bismuth Not Applicable 7440-69-9 16682734 105143
7 Bismuth tripotassium dicitrate Not Applicable
8 Neurotransmitter Agents Not Applicable
9 Antacids Not Applicable
10 Ranitidine bismuth citrate Not Applicable
11 Histamine H2 Antagonists Not Applicable
12 Histamine Antagonists Not Applicable
13 Gastrointestinal Agents Not Applicable
14
Histamine Phosphate Not Applicable 51-74-1 65513

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Extending Acute Stroke Trials to the Aerial Inter-hospital Transfer Setting Completed NCT00585351 Not Applicable Ranitidine;Placebo
2 Feasibility of a Water-soluble Contrast Application Into Dysphagia Evaluation Completed NCT03598491
3 Syndrome and Aspiration Pneumonia in Intensive Care Completed NCT01881672
4 Role of Endotracheal Suction on the Occurrence of Meconium Aspiration Syndrome in Non-vigorous Meconium Stained Babies Completed NCT01758822 Not Applicable
5 Early Stop(Ruling) of the Antibiotic Treatment During Pneumopathies d' Inhalation Not yet recruiting NCT03763799 Not Applicable

Search NIH Clinical Center for Toxic Pneumonitis

Genetic Tests for Toxic Pneumonitis

Anatomical Context for Toxic Pneumonitis

MalaCards organs/tissues related to Toxic Pneumonitis:

41
Lung

Publications for Toxic Pneumonitis

Articles related to Toxic Pneumonitis:

# Title Authors Year
1
Moldy environments and toxic pneumonitis. ( 18842696 )
2008
2
Toxic pneumonitis caused by inhalation of hydrocarbon waterproofing spray in two dogs. ( 17605667 )
2007
3
Horse rug lung: toxic pneumonitis due to fluorocarbon inhalation. ( 15901890 )
2005
4
Acute toxic pneumonitis complicating chronic obstructive pulmonary disease (COPD) in a farmer. ( 15376219 )
2004
5
Pulmonary infiltrates in patients with haematologic malignancies: transbronchial lung biopsy increases the diagnostic yield with respect to neoplastic infiltrates and toxic pneumonitis. ( 15133629 )
2004
6
Toxic pneumonitis in an adolescent following exposure to Snow Storm tablets. ( 3170309 )
1988
7
Toxic pneumonitis from mixing household cleaners. ( 3940787 )
1986

Variations for Toxic Pneumonitis

Expression for Toxic Pneumonitis

Search GEO for disease gene expression data for Toxic Pneumonitis.

Pathways for Toxic Pneumonitis

GO Terms for Toxic Pneumonitis

Biological processes related to Toxic Pneumonitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.56 LBP TLR4
2 defense response to Gram-negative bacterium GO:0050829 9.55 LBP TLR4
3 regulation of inflammatory response GO:0050727 9.54 SCGB1A1 TLR4
4 positive regulation of interleukin-6 production GO:0032755 9.52 LBP TLR4
5 positive regulation of tumor necrosis factor production GO:0032760 9.51 LBP TLR4
6 negative regulation of tumor necrosis factor production GO:0032720 9.49 LBP TLR4
7 toll-like receptor signaling pathway GO:0002224 9.48 LBP TLR4
8 lipopolysaccharide-mediated signaling pathway GO:0031663 9.46 LBP TLR4
9 negative regulation of interferon-gamma production GO:0032689 9.43 SCGB1A1 TLR4
10 positive regulation of interleukin-8 production GO:0032757 9.4 LBP TLR4
11 positive regulation of chemokine production GO:0032722 9.37 LBP TLR4
12 response to lipopolysaccharide GO:0032496 9.33 LBP SCGB1A1 TLR4
13 positive regulation of macrophage activation GO:0043032 9.32 LBP TLR4
14 toll-like receptor 4 signaling pathway GO:0034142 9.26 LBP TLR4
15 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 8.96 LBP TLR4
16 cellular response to lipoteichoic acid GO:0071223 8.62 LBP TLR4

Molecular functions related to Toxic Pneumonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 LBP TLR4

Sources for Toxic Pneumonitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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