MCID: TXC007
MIFTS: 22

Toxic Pneumonitis

Categories: Respiratory diseases

Aliases & Classifications for Toxic Pneumonitis

MalaCards integrated aliases for Toxic Pneumonitis:

Name: Toxic Pneumonitis 12 15 70
Acute Pulmonary Edema Due to Fumes and/or Vapors 70
Acute Chemical Fume Pulmonary Edema 12
Acute Chemical Pulmonary Edema 12

Classifications:



External Ids:

Disease Ontology 12 DOID:551
ICD9CM 34 506.9
UMLS 70 C0041881 C0155895 C3714582

Summaries for Toxic Pneumonitis

Disease Ontology : 12 A pneumonia that is an acute inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors. It is a sentinel health event (occupational) associated with exposure to ammonia (refrigeration, fertilizer, and oil refining industries), chlorine (alkali and bleach industries), nitrogen oxides (silo fillers, arc welders, and nitric acid industry), sulfur dioxide (paper, refrigeration, and oil refining industries), cadmium (processors and cadmium smelters), trimellitic anhydride (plastics and organic chemical synthesis), and vanadium pentoxide (boilermakers). The two types of pulmonary agents are central and peripheral. Central pulmonary agents, for example, ammonia, are water soluble irritants that injure the upper airways. Peripheral pulmonary agents, for example, phosgene, NOx, and PFIB, are slightly water soluble irritants that injure the alveolar-capillary membranes. Chlorine has both central and peripheral effects.

MalaCards based summary : Toxic Pneumonitis, also known as acute pulmonary edema due to fumes and/or vapors, is related to pulmonary disease, chronic obstructive and aspiration pneumonitis. An important gene associated with Toxic Pneumonitis is LBP (Lipopolysaccharide Binding Protein). Affiliated tissues include lung and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Toxic Pneumonitis

Graphical network of the top 20 diseases related to Toxic Pneumonitis:



Diseases related to Toxic Pneumonitis

Symptoms & Phenotypes for Toxic Pneumonitis

GenomeRNAi Phenotypes related to Toxic Pneumonitis according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.6 SCGB1A1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.6 SCGB1A1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.6 LBP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.6 LBP
5 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.6 SCGB1A1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.6 SFTPB
7 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.6 SCGB1A1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-167 9.6 LBP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-20 9.6 SFTPB
10 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.6 SFTPB
11 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.6 SCGB1A1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.6 LBP
13 Increased shRNA abundance (Z-score > 2) GR00366-A-55 9.6 SFTPB
14 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.6 LBP
15 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.6 SCGB1A1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.6 SFTPB
17 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.6 SFTPB
18 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.6 SCGB1A1 SFTPB

Drugs & Therapeutics for Toxic Pneumonitis

Search Clinical Trials , NIH Clinical Center for Toxic Pneumonitis

Genetic Tests for Toxic Pneumonitis

Anatomical Context for Toxic Pneumonitis

MalaCards organs/tissues related to Toxic Pneumonitis:

40
Lung, Bone Marrow

Publications for Toxic Pneumonitis

Articles related to Toxic Pneumonitis:

(show all 38)
# Title Authors PMID Year
1
Choking agents and chlorine gas - History, pathophysiology, clinical effects and treatment. 61
31811912 2020
2
[Harmful biological agents in municipal waste thermal treatment plants]. 61
30653196 2019
3
Assessment of Workers' Exposure to Grain Dust and Bioaerosols During the Loading of Vessels' Hold: An Example at a Port in the Province of Québec. 61
28637341 2017
4
Pantoea agglomerans: a mysterious bacterium of evil and good. Part II--Deleterious effects: Dust-borne endotoxins and allergens--focus on grain dust, other agricultural dusts and wood dust. 61
27007514 2016
5
Fire-eater's lung. 61
28009034 2016
6
Significance of new lung infiltrates in outpatients after lung and heart-lung transplantation. 61
24725092 2014
7
Fire eater's lung: retrospective analysis of 123 cases reported to a National Poison Center. 61
23796914 2014
8
Exposures to thoracic particulate matter, endotoxin, and glucan during post-Hurricane Katrina restoration work, New Orleans 2005-2012. 61
24283332 2014
9
Respiratory health effects associated with restoration work in post-Hurricane Katrina New Orleans. 61
23365586 2012
10
Biological agents as occupational hazards - selected issues. 61
22216801 2011
11
Endotoxin and cancer. 61
19750096 2009
12
Recent advances in understanding the biomolecular basis of chronic beryllium disease: a review. 61
19658317 2009
13
Moldy environments and toxic pneumonitis. 61
18842696 2008
14
Toxic pneumonitis caused by inhalation of hydrocarbon waterproofing spray in two dogs. 61
17605667 2007
15
Airways inflammation among workers in poultry houses. 61
16395591 2006
16
Microbial cell wall agents as an occupational hazard. 61
15992841 2005
17
Horse rug lung: toxic pneumonitis due to fluorocarbon inhalation. 61
15901890 2005
18
Clara cell protein and surfactant protein B in garbage collectors and in wastewater workers exposed to bioaerosols. 61
15772810 2005
19
Acute toxic pneumonitis complicating chronic obstructive pulmonary disease (COPD) in a farmer. 61
15376219 2004
20
Pulmonary infiltrates in patients with haematologic malignancies: transbronchial lung biopsy increases the diagnostic yield with respect to neoplastic infiltrates and toxic pneumonitis. 61
15133629 2004
21
Work-related symptoms and inflammation among sewage plant operatives. 61
15070030 2004
22
Region-related risk factors for respiratory symptoms in European and Californian farmers. 61
12608449 2003
23
Work related symptoms among sewage workers: a nationwide survey in Sweden. 61
12151615 2002
24
Electrophysiological and histopathological evaluation of respiratory tract, diaphragm, and phrenic nerve after dichlorvos inhalation in rats. 61
12122580 2002
25
Endotoxin in the environment--exposure and effects. 61
12230914 2002
26
Surfactant and surfactant inhibitors in meconium aspiration syndrome. 61
11148523 2001
27
[Investigations on airborne microorganisms in animal stables. 3: Relationship between inhalable endotoxin, inhalable dust and airborne bacteria in a hen house]. 61
10994253 2000
28
Fungal spores: hazardous to health? 61
10423389 1999
29
Herbicide (Roundup) pneumonitis. 61
9872216 1998
30
Many faces of pulmonary aspergillosis. 61
9762804 1998
31
[Toxic pneumonitis in a hockey player. Poisonous gases are produced by ice machines]. 61
8965558 1996
32
Nitrogen dioxide pneumonitis in ice hockey players. 61
8642238 1996
33
In vitro and in vivo sensitivity of a non-mouse-adapted influenza A (Beijing) virus infection to amantadine and ribavirin. 61
8529436 1995
34
[Alveolar opacities and busulfan pneumonia]. 61
8451493 1993
35
Bone marrow transplantation: clinical and radiologic aspects. 61
1887115 1991
36
[First aid for irritant gas inhalation in an industry]. 61
2595617 1989
37
Toxic pneumonitis in an adolescent following exposure to Snow Storm tablets. 61
3170309 1988
38
Toxic pneumonitis from mixing household cleaners. 61
3940787 1986

Variations for Toxic Pneumonitis

Expression for Toxic Pneumonitis

Search GEO for disease gene expression data for Toxic Pneumonitis.

Pathways for Toxic Pneumonitis

GO Terms for Toxic Pneumonitis

Cellular components related to Toxic Pneumonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.46 SFTPB SCGB1A1 RNASE3 LBP
2 extracellular region GO:0005576 9.02 SFTPB SCGB1A1 RNASE3 LBP KLK9
3 secretory granule GO:0030141 8.96 SCGB1A1 KLK9

Biological processes related to Toxic Pneumonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.16 SCGB1A1 LBP
2 defense response to Gram-positive bacterium GO:0050830 8.96 RNASE3 LBP
3 defense response to Gram-negative bacterium GO:0050829 8.62 RNASE3 LBP

Molecular functions related to Toxic Pneumonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 RNASE3 LBP

Sources for Toxic Pneumonitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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