MCID: TXC007
MIFTS: 35

Toxic Pneumonitis

Categories: Respiratory diseases

Aliases & Classifications for Toxic Pneumonitis

MalaCards integrated aliases for Toxic Pneumonitis:

Name: Toxic Pneumonitis 12 15 72
Acute Pulmonary Edema Due to Fumes and/or Vapors 72
Acute Chemical Fume Pulmonary Edema 12
Acute Chemical Pulmonary Edema 12

Classifications:



External Ids:

Disease Ontology 12 DOID:551
ICD9CM 35 506.9
UMLS 72 C0041881 C0155895 C3714582

Summaries for Toxic Pneumonitis

Disease Ontology : 12 A pneumonia that is an acute inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors. It is a sentinel health event (occupational) associated with exposure to ammonia (refrigeration, fertilizer, and oil refining industries), chlorine (alkali and bleach industries), nitrogen oxides (silo fillers, arc welders, and nitric acid industry), sulfur dioxide (paper, refrigeration, and oil refining industries), cadmium (processors and cadmium smelters), trimellitic anhydride (plastics and organic chemical synthesis), and vanadium pentoxide (boilermakers). The two types of pulmonary agents are central and peripheral. Central pulmonary agents, for example, ammonia, are water soluble irritants that injure the upper airways. Peripheral pulmonary agents, for example, phosgene, NOx, and PFIB, are slightly water soluble irritants that injure the alveolar-capillary membranes. Chlorine has both central and peripheral effects.

MalaCards based summary : Toxic Pneumonitis, also known as acute pulmonary edema due to fumes and/or vapors, is related to pulmonary disease, chronic obstructive and aspiration pneumonitis. An important gene associated with Toxic Pneumonitis is LBP (Lipopolysaccharide Binding Protein), and among its related pathways/superpathways are Innate Immune System and HIV Life Cycle. Affiliated tissues include lung, heart and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Toxic Pneumonitis

Diseases related to Toxic Pneumonitis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 60, show less)
# Related Disease Score Top Affiliating Genes
1 pulmonary disease, chronic obstructive 29.6 TLR2 SFTPB SCGB1A1
2 aspiration pneumonitis 11.7
3 paraquat lung 10.6 SFTPB SCGB1A1
4 meconium aspiration syndrome 10.4 SFTPB SCGB1A1
5 urethritis 10.4 TLR6 TLR1
6 variola major 10.3 TLR4 TLR3
7 ariboflavinosis 10.2 TLR6 TLR4
8 prosthetic joint infection 10.1 TLR4 TLR2
9 trench fever 10.1 TLR4 TLR2
10 mucocutaneous leishmaniasis 10.1 TLR9 TLR3
11 fungal keratitis 10.1 TLR4 TLR2
12 acute cervicitis 10.1 TLR4 TLR2
13 mycobacterium abscessus 10.1 TLR2 TLR1
14 bacterial pneumonia 10.0 TLR9 TLR4 SFTPB
15 ocular toxoplasmosis 10.0 TLR9 TLR5 TLR1
16 bronchiolitis 10.0 TLR9 TLR4 TLR10
17 neurosyphilis 10.0 TLR6 TLR2 TLR1
18 superficial basal cell carcinoma 10.0 TLR9 TLR8 TLR7
19 lyme disease 9.9 TLR6 TLR2 TLR1
20 spondylarthropathy 9.9 TLR4 TLR2
21 crimean-congo hemorrhagic fever 9.9 TLR8 TLR10
22 neisseria meningitidis infection 9.9 TLR4 TLR2
23 gastric cardia carcinoma 9.9 TLR4 ANO1
24 ileitis 9.9 TLR5 TLR4 TLR2
25 filarial elephantiasis 9.8 TLR9 TLR2
26 legionellosis 9.8 TLR5 TLR4 TLR2
27 mesenteric lymphadenitis 9.8 TLR2 LBP
28 juvenile nasopharyngeal angiofibroma 9.8 TLR9 TLR7 TLR3
29 pneumothorax 9.8
30 substance abuse 9.8
31 interstitial lung disease 9.8
32 lung disease 9.8
33 mouth disease 9.8 TLR9 TLR4 TLR3
34 aspergillosis 9.7 TLR9 TLR4 TLR2
35 oral cavity cancer 9.7 TLR9 TLR6 TLR2
36 toxoplasmosis 9.7 TLR9 TLR4 TLR2
37 myositis fibrosa 9.7 TLR9 TLR4 TLR2
38 middle ear disease 9.7 TLR9 TLR4 TLR2
39 keratitis, hereditary 9.7 TLR9 TLR4 TLR2
40 q fever 9.7 TLR4 TLR2 TLR10 TLR1
41 primary bacterial infectious disease 9.7 TLR9 TLR4 TLR2
42 cutaneous leishmaniasis 9.7 TLR9 TLR4 TLR2
43 leishmaniasis 9.7 TLR9 TLR4 TLR2
44 visceral leishmaniasis 9.6 TLR9 TLR4 TLR2
45 penicilliosis 9.6 TLR6 TLR4 TLR2 TLR1
46 pelvic inflammatory disease 9.6 TLR6 TLR4 TLR2 TLR1
47 periodontitis 9.6 TLR9 TLR4 TLR2
48 viral infectious disease 9.5 TLR9 TLR8 TLR7 TLR3
49 suppurative otitis media 9.4 TLR9 TLR5 TLR4 TLR2
50 septic arthritis 9.4 TLR9 TLR5 TLR4 TLR2
51 mycobacterium tuberculosis 1 9.4 TLR9 TLR4 TLR2 TLR1
52 melioidosis 9.4 TLR5 TLR4 TLR2 TLR10 TLR1
53 myd88 deficiency 9.3 TLR6 TLR5 TLR4 TLR2 TLR1
54 pneumonia 9.2 TLR9 TLR5 TLR4 TLR2 SFTPB
55 invasive aspergillosis 9.2 TLR9 TLR6 TLR4 TLR2 TLR1
56 filariasis 9.2 TLR9 TLR6 TLR4 TLR2 TLR1
57 immune system disease 9.1 TLR9 TLR6 TLR5 TLR3 TLR10 TLR1
58 irak4 deficiency 9.1 TLR6 TLR5 TLR4 TLR2 TLR10 TLR1
59 systemic lupus erythematosus 8.8 TLR9 TLR7 TLR5 TLR4 TLR2
60 bacterial infectious disease 8.5 TLR9 TLR5 TLR4 TLR3 TLR2 TLR1

Graphical network of the top 20 diseases related to Toxic Pneumonitis:



Diseases related to Toxic Pneumonitis

Symptoms & Phenotypes for Toxic Pneumonitis

MGI Mouse Phenotypes related to Toxic Pneumonitis:

46 (showing 7, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.11 LBP POLB TLR1 TLR2 TLR3 TLR4
2 homeostasis/metabolism MP:0005376 10.1 ANO1 LBP POLB SCGB1A1 SFTPB TLR2
3 immune system MP:0005387 10.03 LBP POLB SCGB1A1 TLR1 TLR2 TLR3
4 digestive/alimentary MP:0005381 9.88 ANO1 POLB TLR2 TLR4 TLR5 TLR9
5 mortality/aging MP:0010768 9.85 ANO1 POLB SCGB1A1 SFTPB TLR2 TLR3
6 renal/urinary system MP:0005367 9.56 ANO1 POLB SCGB1A1 TLR2 TLR4 TLR7
7 respiratory system MP:0005388 9.23 ANO1 POLB SCGB1A1 SFTPB TLR2 TLR3

Drugs & Therapeutics for Toxic Pneumonitis

Search Clinical Trials , NIH Clinical Center for Toxic Pneumonitis

Genetic Tests for Toxic Pneumonitis

Anatomical Context for Toxic Pneumonitis

MalaCards organs/tissues related to Toxic Pneumonitis:

41
Lung, Heart, Bone, Bone Marrow

Publications for Toxic Pneumonitis

Articles related to Toxic Pneumonitis:

(showing 37, show less)
# Title Authors PMID Year
1
[Harmful biological agents in municipal waste thermal treatment plants]. 38
30653196 2019
2
Assessment of Workers' Exposure to Grain Dust and Bioaerosols During the Loading of Vessels' Hold: An Example at a Port in the Province of Québec. 38
28637341 2017
3
Fire-eater's lung. 38
28009034 2016
4
Pantoea agglomerans: a mysterious bacterium of evil and good. Part II--Deleterious effects: Dust-borne endotoxins and allergens--focus on grain dust, other agricultural dusts and wood dust. 38
27007514 2016
5
Significance of new lung infiltrates in outpatients after lung and heart-lung transplantation. 38
24725092 2014
6
Exposures to thoracic particulate matter, endotoxin, and glucan during post-Hurricane Katrina restoration work, New Orleans 2005-2012. 38
24283332 2014
7
Fire eater's lung: retrospective analysis of 123 cases reported to a National Poison Center. 38
23796914 2014
8
Respiratory health effects associated with restoration work in post-Hurricane Katrina New Orleans. 38
23365586 2012
9
Biological agents as occupational hazards - selected issues. 38
22216801 2011
10
Endotoxin and cancer. 38
19750096 2009
11
Recent advances in understanding the biomolecular basis of chronic beryllium disease: a review. 38
19658317 2009
12
Moldy environments and toxic pneumonitis. 38
18842696 2008
13
Toxic pneumonitis caused by inhalation of hydrocarbon waterproofing spray in two dogs. 38
17605667 2007
14
Airways inflammation among workers in poultry houses. 38
16395591 2006
15
Microbial cell wall agents as an occupational hazard. 38
15992841 2005
16
Horse rug lung: toxic pneumonitis due to fluorocarbon inhalation. 38
15901890 2005
17
Clara cell protein and surfactant protein B in garbage collectors and in wastewater workers exposed to bioaerosols. 38
15772810 2005
18
Acute toxic pneumonitis complicating chronic obstructive pulmonary disease (COPD) in a farmer. 38
15376219 2004
19
Pulmonary infiltrates in patients with haematologic malignancies: transbronchial lung biopsy increases the diagnostic yield with respect to neoplastic infiltrates and toxic pneumonitis. 38
15133629 2004
20
Work-related symptoms and inflammation among sewage plant operatives. 38
15070030 2004
21
Region-related risk factors for respiratory symptoms in European and Californian farmers. 38
12608449 2003
22
Work related symptoms among sewage workers: a nationwide survey in Sweden. 38
12151615 2002
23
Electrophysiological and histopathological evaluation of respiratory tract, diaphragm, and phrenic nerve after dichlorvos inhalation in rats. 38
12122580 2002
24
Endotoxin in the environment--exposure and effects. 38
12230914 2002
25
Surfactant and surfactant inhibitors in meconium aspiration syndrome. 38
11148523 2001
26
[Investigations on airborne microorganisms in animal stables. 3: Relationship between inhalable endotoxin, inhalable dust and airborne bacteria in a hen house]. 38
10994253 2000
27
Fungal spores: hazardous to health? 38
10423389 1999
28
Herbicide (Roundup) pneumonitis. 38
9872216 1998
29
Many faces of pulmonary aspergillosis. 38
9762804 1998
30
[Toxic pneumonitis in a hockey player. Poisonous gases are produced by ice machines]. 38
8965558 1996
31
Nitrogen dioxide pneumonitis in ice hockey players. 38
8642238 1996
32
In vitro and in vivo sensitivity of a non-mouse-adapted influenza A (Beijing) virus infection to amantadine and ribavirin. 38
8529436 1995
33
[Alveolar opacities and busulfan pneumonia]. 38
8451493 1993
34
Bone marrow transplantation: clinical and radiologic aspects. 38
1887115 1991
35
[First aid for irritant gas inhalation in an industry]. 38
2595617 1989
36
Toxic pneumonitis in an adolescent following exposure to Snow Storm tablets. 38
3170309 1988
37
Toxic pneumonitis from mixing household cleaners. 38
3940787 1986

Variations for Toxic Pneumonitis

Expression for Toxic Pneumonitis

Search GEO for disease gene expression data for Toxic Pneumonitis.

Pathways for Toxic Pneumonitis

Pathways related to Toxic Pneumonitis according to GeneCards Suite gene sharing:

(showing 26, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
2
Show member pathways
13.57 TLR6 TLR5 TLR4 TLR3 TLR2 TLR10
3
Show member pathways
13.56 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
4
Show member pathways
13.39 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
5
Show member pathways
13.24 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
6
Show member pathways
13.15 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
7
Show member pathways
12.78 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
8 12.58 TLR9 TLR8 TLR7 TLR6 TLR3 TLR2
9
Show member pathways
12.36 TLR6 TLR4 TLR2 TLR1
10
Show member pathways
12.3 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
11
Show member pathways
12.3 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
12 12.29 TLR9 TLR6 TLR4 TLR2 TLR1 LBP
13
Show member pathways
12.23 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
14
Show member pathways
12.22 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
15
Show member pathways
12.11 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
16 12.07 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
17
Show member pathways
12.07 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
18 12 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
19 11.98 TLR6 TLR4 TLR2
20
Show member pathways
11.97 TLR6 TLR4 TLR2 TLR1
21
Show member pathways
11.9 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
22 11.69 TLR5 TLR4 LBP
23 11.52 TLR5 TLR4 TLR2
24 11.45 TLR9 TLR4 TLR2
25 11.03 TLR2 TLR1
26 11 TLR4 TLR3

GO Terms for Toxic Pneumonitis

Cellular components related to Toxic Pneumonitis according to GeneCards Suite gene sharing:

(showing 10, show less)
# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 TLR6 TLR4 TLR3 TLR2 TLR10 TLR1
2 cytoplasmic vesicle GO:0031410 9.8 TLR9 TLR7 TLR6 TLR2 TLR1
3 phagocytic vesicle membrane GO:0030670 9.43 TLR6 TLR2 TLR1
4 endosome membrane GO:0010008 9.35 TLR9 TLR8 TLR7 TLR4 TLR3
5 early phagosome GO:0032009 9.32 TLR9 TLR7
6 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.16 TLR2 TLR1
7 endolysosome membrane GO:0036020 8.92 TLR9 TLR8 TLR7 TLR3
8 membrane GO:0016020 10.26 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
9 plasma membrane GO:0005886 10.16 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
10 integral component of membrane GO:0016021 10.11 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4

Biological processes related to Toxic Pneumonitis according to GeneCards Suite gene sharing:

(showing 76, show less)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of tumor necrosis factor production GO:0032760 9.98 TLR9 TLR4 TLR3 TLR2 LBP
2 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.97 TLR9 TLR7 TLR4 TLR3 TLR2
3 cellular response to lipopolysaccharide GO:0071222 9.92 TLR5 TLR4 LBP
4 positive regulation of interferon-beta production GO:0032728 9.92 TLR9 TLR4 TLR3 TLR2
5 positive regulation of interleukin-12 production GO:0032735 9.92 TLR9 TLR4 TLR3 TLR2
6 cellular response to interferon-gamma GO:0071346 9.91 TLR4 TLR3 TLR2
7 microglial cell activation GO:0001774 9.91 TLR8 TLR7 TLR6 TLR3 TLR2
8 defense response to Gram-negative bacterium GO:0050829 9.9 TLR9 TLR4 LBP
9 positive regulation of JNK cascade GO:0046330 9.9 TLR9 TLR4 TLR3
10 I-kappaB phosphorylation GO:0007252 9.89 TLR9 TLR7 TLR4 TLR3 TLR2
11 positive regulation of interferon-beta biosynthetic process GO:0045359 9.88 TLR9 TLR8 TLR7 TLR4 TLR3
12 positive regulation of chemokine production GO:0032722 9.88 TLR9 TLR7 TLR4 TLR3 TLR2 LBP
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.87 TLR6 TLR5 TLR4
14 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.87 TLR9 TLR8 TLR7 TLR3
15 positive regulation of interleukin-8 production GO:0032757 9.87 TLR9 TLR7 TLR5 TLR4 TLR3 TLR2
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.86 TLR4 TLR2 LBP
17 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.86 TLR9 TLR8 TLR7 TLR4
18 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.84 TLR6 TLR4 TLR3
19 positive regulation of interleukin-10 production GO:0032733 9.84 TLR9 TLR4 TLR2
20 positive regulation of toll-like receptor signaling pathway GO:0034123 9.84 TLR9 TLR5 TLR3 TLR2
21 positive regulation of macrophage activation GO:0043032 9.83 TLR6 TLR4 LBP
22 toll-like receptor 9 signaling pathway GO:0034162 9.83 TLR9 TLR8 TLR7
23 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.83 TLR9 TLR4 TLR2
24 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.83 TLR9 TLR8 TLR7 TLR3
25 cell activation GO:0001775 9.82 TLR6 TLR2 TLR1
26 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.82 TLR4 TLR1 LBP
27 cellular response to lipoteichoic acid GO:0071223 9.81 TLR4 TLR2 LBP
28 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.81 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
29 regulation of cytokine secretion GO:0050707 9.8 TLR9 TLR8 TLR6 TLR5 TLR2 TLR10
30 positive regulation of interleukin-1 beta secretion GO:0050718 9.75 TLR8 TLR4
31 negative regulation of interleukin-6 production GO:0032715 9.75 TLR9 TLR4
32 negative regulation of interferon-gamma production GO:0032689 9.75 TLR4 SCGB1A1
33 negative regulation of osteoclast differentiation GO:0045671 9.75 TLR4 TLR3
34 necroptotic process GO:0070266 9.74 TLR4 TLR3
35 activation of NF-kappaB-inducing kinase activity GO:0007250 9.74 TLR6 TLR3
36 toll-like receptor 4 signaling pathway GO:0034142 9.74 TLR4 LBP
37 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.74 TLR6 TLR4
38 positive regulation of interleukin-8 secretion GO:2000484 9.74 TLR2 TLR1
39 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.74 TLR6 TLR4
40 response to molecule of bacterial origin GO:0002237 9.73 TLR9 TLR2
41 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.73 TLR4 TLR3
42 macrophage activation GO:0042116 9.73 TLR4 TLR1
43 interleukin-1 beta secretion GO:0050702 9.73 TLR6 TLR4
44 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.72 TLR6 TLR4
45 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.72 TLR6 TLR4
46 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.72 TLR6 TLR1
47 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.72 TLR4 TLR3
48 tumor necrosis factor production GO:0032640 9.72 TLR9 TLR2
49 positive regulation of interleukin-18 production GO:0032741 9.71 TLR9 TLR2
50 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.71 TLR6 TLR2
51 cellular response to diacyl bacterial lipopeptide GO:0071726 9.7 TLR6 TLR2
52 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.7 TLR2 TLR1
53 positive regulation of oxidative stress-induced neuron death GO:1903223 9.69 TLR6 TLR4
54 nitric oxide metabolic process GO:0046209 9.69 TLR6 TLR2
55 cellular response to triacyl bacterial lipopeptide GO:0071727 9.69 TLR2 TLR1
56 response to bacterial lipoprotein GO:0032493 9.68 TLR6 TLR2
57 regulation of dendritic cell cytokine production GO:0002730 9.68 TLR4 TLR3
58 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.68 TLR4 TLR2
59 detection of triacyl bacterial lipopeptide GO:0042495 9.67 TLR2 TLR1
60 detection of diacyl bacterial lipopeptide GO:0042496 9.67 TLR6 TLR2
61 toll-like receptor signaling pathway GO:0002224 9.65 TLR9 TLR8 TLR7 TLR6 TLR4 TLR3
62 inflammatory response GO:0006954 9.36 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
63 signal transduction GO:0007165 10.35 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
64 immune response GO:0006955 10.19 TLR9 TLR8 TLR7 TLR6 TLR4 TLR2
65 immune system process GO:0002376 10.17 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
66 positive regulation of gene expression GO:0010628 10.11 TLR9 TLR6 TLR4 TLR3 TLR2
67 innate immune response GO:0045087 10.11 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
68 defense response to bacterium GO:0042742 10.1 TLR9 TLR6 TLR5 TLR4 TLR3 LBP
69 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.03 TLR9 TLR6 TLR4 TLR3 TLR2
70 positive regulation of inflammatory response GO:0050729 10.02 TLR9 TLR7 TLR4 TLR3 TLR2 TLR10
71 defense response to virus GO:0051607 10.01 TLR9 TLR8 TLR7 TLR3
72 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.01 TLR9 TLR6 TLR4 TLR3
73 cellular response to mechanical stimulus GO:0071260 10.01 TLR8 TLR7 TLR5 TLR4 TLR3
74 response to lipopolysaccharide GO:0032496 10 TLR4 TLR2 SCGB1A1 LBP
75 I-kappaB kinase/NF-kappaB signaling GO:0007249 10 TLR9 TLR8 TLR7 TLR4 TLR3
76 positive regulation of interleukin-6 production GO:0032755 10 TLR9 TLR8 TLR7 TLR4 TLR3 TLR2

Molecular functions related to Toxic Pneumonitis according to GeneCards Suite gene sharing:

(showing 11, show less)
# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.95 TLR6 TLR4 TLR3 TLR2 TLR10 TLR1
2 signaling receptor activity GO:0038023 9.73 TLR8 TLR6 TLR4 TLR3 TLR2 TLR1
3 double-stranded RNA binding GO:0003725 9.61 TLR8 TLR7 TLR3
4 lipopolysaccharide binding GO:0001530 9.5 TLR4 TLR2 LBP
5 interleukin-1 receptor binding GO:0005149 9.49 TLR9 TLR5
6 siRNA binding GO:0035197 9.46 TLR9 TLR7
7 signaling pattern recognition receptor activity GO:0008329 9.46 TLR9 TLR8 TLR7 TLR2
8 lipopolysaccharide receptor activity GO:0001875 9.4 TLR4 TLR2
9 Toll-like receptor 2 binding GO:0035663 9.37 TLR6 TLR1
10 transmembrane signaling receptor activity GO:0004888 9.28 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
11 lipopeptide binding GO:0071723 9.26 TLR6 TLR2 TLR1 LBP

Sources for Toxic Pneumonitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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