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MCID: TXC005
MIFTS: 62

Toxic Shock Syndrome

Categories: Infectious diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Toxic Shock Syndrome

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MalaCards integrated aliases for Toxic Shock Syndrome:

Name: Toxic Shock Syndrome 12 77 56 15 74
Staphylococcal Toxic Shock Syndrome 74
Shock, Septic 45
Septic Shock 17
Toxic Shock 12
Tss 12

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:14115
ICD9CM 36 040.82
MeSH 45 D012772
NCIt 51 C35498
SNOMED-CT 69 18504008
ICD10 34 A48.3 R57.2
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Summaries for Toxic Shock Syndrome

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Disease Ontology : 12 A commensal bacterial infectious disease that results in infection, has material basis in Streptococcus pyogenes or has material basis in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has symptom fever, has symptom rash, has symptom hypotension, has symptom multiorgan failure, has symptom desquamation, has symptom vomiting, has symptom diarrhea, has symptom headache, and has symptom nonfocal neurologic abnormalities.

MalaCards based summary : Toxic Shock Syndrome, also known as staphylococcal toxic shock syndrome, is related to staphylococcal toxic shock syndrome and streptococcal toxic-shock syndrome, and has symptoms including hypotension, fever and vomiting. An important gene associated with Toxic Shock Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Clindamycin and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and kidney, and related phenotypes are hematopoietic system and homeostasis/metabolism

CDC : 3 Educational Materials

Wikipedia : 77 Toxic shock syndrome (TSS) is a condition caused by bacterial toxins. Symptoms may include fever, rash,... more...

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Related Diseases for Toxic Shock Syndrome

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Diseases related to Toxic Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 667)
# Related Disease Score Top Affiliating Genes
1 staphylococcal toxic shock syndrome 34.2 CIITA HMGB1 IFNG IL1B TNF
2 streptococcal toxic-shock syndrome 33.4 C1S CXCL8 IL2 IL6 LTA MYOM2
3 fasciitis 31.2 CXCL8 IL6 TNF
4 burns 31.0 IL1B SERPINC1 TNF
5 acute respiratory distress syndrome 31.0 CXCL8 IL1B IL6 LTA TNF
6 kawasaki disease 30.8 IL10 IL6 TNF
7 pharyngitis 30.7 CXCL8 IL1B MYOM2
8 necrotizing fasciitis 30.6 CXCL8 IL2 IL6 LTA MYOM2
9 mastitis 30.6 CXCL8 IL6 TLR2
10 chikungunya 30.6 IL1B IL6 TNF
11 acute pyelonephritis 30.6 CXCL8 IL10 IL6
12 joint disorders 30.5 IL1B IL6 TNF
13 spotted fever 30.5 IFNG IL10 TNF
14 adult respiratory distress syndrome 30.5 CXCL8 IL10 IL6 TNF
15 shigellosis 30.5 CXCL8 IL10 LTA
16 vaginitis 30.4 CXCL8 IL1B IL6
17 leukomalacia 30.4 IL6 TNF
18 cytomegalovirus infection 30.3 CXCL8 IL1B IL6 TNF
19 purpura 30.3 IL6 SERPINC1 TNF
20 reactive arthritis 30.3 IFNG IL10 TNF
21 endomyocardial fibrosis 30.3 IL10 IL4 TNF
22 endometritis 30.3 IL1B IL6 TNF
23 dengue shock syndrome 30.2 IL1B IL6 TNF
24 adult-onset still's disease 30.2 IL1B IL6 TNF
25 sudden infant death syndrome 30.2 IL10 IL1B IL6 TNF
26 temporal arteritis 30.2 IFNG IL6 TNF
27 arteries, anomalies of 30.2 IL1B IL6 SERPINC1 TNF
28 bacterial pneumonia 30.2 CXCL8 IL6 TLR4
29 bullous impetigo 30.1 EDNRA IL6
30 scleritis 30.1 IFNG IL4 TNF
31 pulmonary disease, chronic obstructive 30.1 CXCL8 IL6 TLR2 TNF
32 acute pancreatitis 30.1 CXCL8 IL10 IL6
33 hepatitis a 30.1 IFNG IL10 TNF
34 plasmodium falciparum malaria 30.1 IFNG IL10 TNF
35 chronic graft versus host disease 30.1 IFNG IL10 TNF
36 rheumatic fever-related antigen 30.1 MYOM2 TLR2
37 herpes zoster 30.1 IFNG IL10 IL2
38 psoriatic arthritis 30.1 IL1B IL6 LTA TNF
39 severe acute respiratory syndrome 30.0 CXCL8 IFNG TNF
40 cystitis 30.0 CXCL8 IL6 TLR4 TNF
41 infective endocarditis 30.0 IL6 TLR2 TNF
42 churg-strauss syndrome 30.0 HMGB1 IL10 TNF
43 pulmonary fibrosis, idiopathic 30.0 CXCL8 IFNG IL1B TNF
44 pyelonephritis 29.9 CXCL8 IL10 IL1B IL6 TLR4 TNF
45 arthritis 29.9 CIITA CXCL8 IFNG IL10 IL1B IL6
46 haemophilus influenzae 29.9 CXCL8 IL1B TLR2 TNF
47 peritonitis 29.9 CXCL8 IL10 IL1B IL6 TLR2 TNF
48 bacterial sepsis 29.8 CXCL8 IL10 TLR4 TNF
49 noonan syndrome 1 29.8 CXCL8 IL1B IL2 IL6 TNF
50 prostatitis 29.8 CXCL8 IL10 IL1B IL2 IL6 TNF

Graphical network of the top 20 diseases related to Toxic Shock Syndrome:



Diseases related to Toxic Shock Syndrome
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Symptoms & Phenotypes for Toxic Shock Syndrome

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Symptoms:

12
  • • hypotension
  • • fever
  • • vomiting
  • • headache
  • • diarrhea
  • • desquamation
  • • rash
  • • multiorgan failure
  • • nonfocal neurologic abnormalities

UMLS symptoms related to Toxic Shock Syndrome:


shock without mention of trauma

MGI Mouse Phenotypes related to Toxic Shock Syndrome:

47 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.37 CIITA EDNRA IFNG IL10 IL1B IL2
2 homeostasis/metabolism MP:0005376 10.36 CIITA EDNRA IFNG IL10 IL1B IL2
3 immune system MP:0005387 10.34 CIITA EDNRA IFNG IL10 IL1B IL2
4 cardiovascular system MP:0005385 10.31 EDNRA IFNG IL10 IL1B IL2 IL6
5 growth/size/body region MP:0005378 10.28 EDNRA IFNG IL10 IL1B IL2 IL4
6 endocrine/exocrine gland MP:0005379 10.25 CIITA EDNRA IFNG IL10 IL2 IL4
7 digestive/alimentary MP:0005381 10.21 EDNRA IFNG IL10 IL2 IL4 IL6
8 mortality/aging MP:0010768 10.21 EDNRA IFNG IL10 IL1B IL2 IL4
9 liver/biliary system MP:0005370 10.16 IFNG IL10 IL2 IL4 IL6 LTA
10 integument MP:0010771 10.13 EDNRA IFNG IL10 IL1B IL4 IL6
11 nervous system MP:0003631 10.06 EDNRA IFNG IL10 IL1B IL4 IL6
12 neoplasm MP:0002006 10.02 IFNG IL10 IL1B IL2 IL6 TLR2
13 muscle MP:0005369 9.95 EDNRA IFNG IL10 IL6 TLR2 TLR4
14 respiratory system MP:0005388 9.85 EDNRA IFNG IL10 IL2 IL4 IL6
15 renal/urinary system MP:0005367 9.8 EDNRA IFNG IL4 IL6 SERPINC1 TLR2
16 skeleton MP:0005390 9.7 CIITA EDNRA IFNG IL10 IL1B IL4
17 vision/eye MP:0005391 9.32 EDNRA IFNG IL10 IL2 IL4 IL6
Sources

Drugs & Therapeutics for Toxic Shock Syndrome

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Drugs for Toxic Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
3
Rifampicin Approved Phase 4 13292-46-1 5381226 5458213
4
Proline Approved, Nutraceutical Phase 4 147-85-3 145742
5
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
6 Antibodies Phase 4,Phase 2
7 Immunoglobulins Phase 4,Phase 2
8 Immunologic Factors Phase 4,Phase 2,Phase 1
9 Rho(D) Immune Globulin Phase 4,Phase 2
10 Immunoglobulins, Intravenous Phase 4,Phase 2
11 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
12 gamma-Globulins Phase 4,Phase 2
13 Anti-Bacterial Agents Phase 4,Phase 3
14 Anti-Infective Agents Phase 4,Phase 3
15 Clindamycin palmitate Phase 4
16 beta-Lactamase Inhibitors Phase 4
17 Amoxicillin-Potassium Clavulanate Combination Phase 4
18 Clindamycin phosphate Phase 4
19 Antibiotics, Antitubercular Phase 4
20 Clavulanic Acids Phase 4
21 Vaccines Phase 2,Phase 1
22
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
23
Iron Approved, Experimental Phase 1 7439-89-6, 15438-31-0 27284 23925
24
Imidazole Experimental, Investigational Phase 1 288-32-4 795
25 Gastrointestinal Agents Phase 1
26 Antacids Phase 1
27 Anti-Ulcer Agents Phase 1
28 Adjuvants, Immunologic Phase 1
29 Monophosphoryl lipid A Phase 1
30 Neurotransmitter Agents
31 Adrenergic Antagonists
32 Adrenergic Agents
33 Adrenergic beta-Antagonists
34 methicillin

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Intravenous Immunoglobulins (IVIG) in Toxic Shock Syndromes in Children Not yet recruiting NCT02899702 Phase 4 PRIVIGEN (CSL Behring);Albumin
2 De-escalation of Empirical Antimicrobial Therapy Study in Severe Sepsis Completed NCT01626612 Phase 3
3 Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot Study Unknown status NCT02219165 Phase 2 Intravenous human immunoglobulin;Albumin
4 Clinical Trial of the BioMed rTSST‐1 Variant Vaccine in Healthy Adults Recruiting NCT02814708 Phase 2
5 Phase I STEBVax in Healthy Adults Completed NCT00974935 Phase 1 Aluminum hydroxide
6 Amendment of rTSST-1 Variant Vaccine Phase 1 Clinical Trial Completed NCT02971670 Phase 1
7 rTSST-1 Variant Vaccine Phase 1 First-in-man Trail Completed NCT02340338 Phase 1
8 Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy Adults Completed NCT01717950 Phase 1
9 Role of Beta-blockers in the Prevention on the Arisen of a Severe Sepsis (TESS) Completed NCT01606631
10 Pediatric Immune Response to Infectious Shock Completed NCT02848144 Not Applicable
11 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
12 Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus Completed NCT01141101
13 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
14 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128
15 Cups or Cash for Girls Trial to Reduce Sexual and Reproductive Harm and School Dropout Recruiting NCT03051789 Not Applicable

Search NIH Clinical Center for Toxic Shock Syndrome

Cochrane evidence based reviews: shock, septic

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Genetic Tests for Toxic Shock Syndrome

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Anatomical Context for Toxic Shock Syndrome

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MalaCards organs/tissues related to Toxic Shock Syndrome:

42
T Cells, Skin, Kidney, Monocytes, Eye, B Cells, Colon
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Publications for Toxic Shock Syndrome

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Articles related to Toxic Shock Syndrome:

(show top 50) (show all 1630)
# Title Authors Year
1
Group A Streptococcus pleuropneumonia associated with toxic shock syndrome in a 64-year-old woman. ( 31068344 )
2019
2
Streptococcal toxic shock syndrome caused by β-hemolytic streptococci: Clinical features and cytokine and chemokine analyses of 15 cases. ( 30744988 )
2019
3
Streptococcal Toxic Shock Syndrome After Insertion of a Levonorgestrel Intrauterine Device. ( 30981616 )
2019
4
Myocardial calcification secondary to toxic shock syndrome: a comparative review of 17 cases. ( 30635313 )
2019
5
Fasciitis and Streptococcal Toxic-shock Syndrome: The Importance of Early Diagnosis and Surgical Management. ( 30740378 )
2018
6
Periocular Necrotizing Fasciitis with Toxic Shock Syndrome. ( 29928226 )
2018
7
Successful Treatment of Streptococcal Toxic Shock Syndrome with Both Diffuse Peritonitis and Necrotizing Fasciitis. ( 30510834 )
2018
8
Innate immune responses following Kawasaki disease and toxic shock syndrome. ( 29447181 )
2018
9
Frequency of enterotoxins, toxic shock syndrome toxin-1, and biofilm formation genes in Staphylococcus aureus isolates from cows with mastitis in the Northeast of Brazil. ( 29429115 )
2018
10
Uncommon cause of pelvic inflammatory disease leading to toxic shock syndrome. ( 30249728 )
2018
11
Clinical and Molecular Epidemiology of Staphylococcal Toxic Shock Syndrome in the United Kingdom. ( 29350159 )
2018
12
Streptococcal toxic shock syndrome with primary group A streptococcus peritonitis in a healthy female. ( 30356961 )
2018
13
A 2-year-old boy with circulatory failure owing to streptococcal toxic shock syndrome: case report. ( 28426384 )
2018
14
Molecular characterization and antibiotic resistance of Streptococcus dysgalactiae subspecies equisimilis isolated from patients with streptococcal toxic shock syndrome. ( 29107650 )
2018
15
Fulminant streptococcal toxic shock syndrome. ( 29741523 )
2018
16
Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis. ( 29788397 )
2018
17
Streptococcal toxic shock syndrome - a life-threatening condition caused by various streptococcal species. ( 30126285 )
2018
18
Successful treatment of out-of-hospital cardiopulmonary arrest due to streptococcal toxic shock syndrome - effectiveness of extracorporeal membrane oxygenation and the rapid antigen group A streptococcus test: a case report. ( 30170621 )
2018
19
Streptococcal toxic shock syndrome in the intensive care unit. ( 30225523 )
2018
20
Streptococcal toxic shock syndrome in a returning traveller. ( 30369302 )
2018
21
Toxic shock syndrome in paediatric thermal injuries: A case series and systematic literature review. ( 28867411 )
2018
22
Toxic shock syndrome: A dermatological emergency. ( 28960233 )
2018
23
Macro- and Microvascular Parameters After Toxic Shock Syndrome. ( 29112091 )
2018
24
The Evaluation and Management of Toxic Shock Syndrome in the Emergency Department: A Review of the Literature. ( 29366615 )
2018
25
Epidemiology and Clinical Relevance of Toxic Shock Syndrome in US Children. ( 29601458 )
2018
26
RS3PE syndrome developing during the course of probable toxic shock syndrome: a case report. ( 29653519 )
2018
27
Impact of Currently Marketed Tampons and Menstrual Cups on Staphylococcus aureus Growth and Toxic Shock Syndrome Toxin 1 Production In Vitro. ( 29678918 )
2018
28
The effect of vaginal microbial communities on colonization by Staphylococcus aureus with the gene for toxic shock syndrome toxin 1 (TSST-1): a case-control study. ( 29762733 )
2018
29
Draft Genome Sequence of Streptococcus suis Strain SsRC-1, a Human Isolate from a Fatal Case of Toxic Shock Syndrome. ( 29773639 )
2018
30
Contribution of toxic shock syndrome toxin-1 to systemic inflammation investigated by a mouse model of cervicovaginal infection with Staphylococcus aureus. ( 29980843 )
2018
31
Epidemiology of toxic shock syndrome toxin-1 harboring Staphylococcus aureus obtained from clinical samples in Iran: A Systematic Review and Meta-analysis. ( 30062367 )
2018
32
Survival from Clostridium toxic shock syndrome: Case report and review of the literature. ( 30081323 )
2018
33
Clinical Manifestations and Bacterial Genomic Analysis of Group A Streptococcus Strains That Cause Pediatric Toxic Shock Syndrome. ( 30085250 )
2018
34
The use of etanercept for treatment of toxic epidermal necrolysis when toxic shock syndrome is in the differential. ( 30175438 )
2018
35
Carriage of the Toxic Shock Syndrome Toxin Gene by Contemporary Community-Associated Staphylococcus aureus Isolates. ( 30285124 )
2018
36
Postpartum Methicillin-Resistant Staphylococcus aureus Toxic Shock Syndrome Caused by a Perineal Infection. ( 30363971 )
2018
37
Streptococcus pyogenes bacteremia and toxic shock syndrome related to Strongyloides stercoralis hyperinfection: a case report. ( 30463627 )
2018
38
Toxic shock syndrome: the great masquerader. ( 30567096 )
2018
39
Septic miscarriage with toxic shock syndrome and disseminated intravascular coagulation (DIC): The role of surgery, recombinant activated factor VII and intravenous immunoglobulin (IVIG). ( 29308782 )
2017
40
Two Catastrophes in One Patient: Drug Reaction with Eosinophilia and Systemic Symptoms and Toxic Shock Syndrome. ( 28721327 )
2017
41
Infective Endocarditis Associated with Streptococcal Toxic Shock Syndrome due to Streptococcus dysgalactiae subsp. equisimilis Infection in a Hemodialysis Patient. ( 29457020 )
2017
42
Post-partum streptococcal toxic shock syndrome associated with necrotizing fasciitis. ( 28725564 )
2017
43
Rare presentation of necrotising fasciitis and streptococcal toxic shock syndrome by group A streptococcus. ( 28954758 )
2017
44
Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid. ( 28299216 )
2017
45
Streptococcal toxic-shock syndrome due to Streptococcus dysgalactiae subspecies equisimilis in breast cancer-related lymphedema: a case report. ( 28705211 )
2017
46
Erratum: Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. ( 28721224 )
2017
47
Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. ( 28580155 )
2017
48
HLA-DR polymorphisms influence in vivo responses to staphylococcal toxic shock syndrome toxin-1 in a transgenic mouse model. ( 27863161 )
2017
49
Pleural empyema and streptococcal toxic shock syndrome due to Streptococcus pyogenes in a healthy Spanish traveler in Japan. ( 28725562 )
2017
50
Group A Streptococcal Peritonitis and Toxic Shock Syndrome in a Postmenopausal Woman. ( 28824068 )
2017
Sources

Variations for Toxic Shock Syndrome

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ClinVar genetic disease variations for Toxic Shock Syndrome:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TNF TNF, -308G-A single nucleotide variant risk factor
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Expression for Toxic Shock Syndrome

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Search GEO for disease gene expression data for Toxic Shock Syndrome.
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Pathways for Toxic Shock Syndrome

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Pathways related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 14.12 C1S CIITA CXCL8 HMGB1 IFNG IL10
2
PEDF Induced Signaling 65
Show member pathways
 13.79 CXCL8 EDNRA IFNG IL10 IL1B IL2
3
TGF-Beta Pathway 65
Show member pathways
 13.63 CXCL8 IFNG IL10 IL1B IL2 IL4
4
Akt Signaling 65
Show member pathways
 13.54 CXCL8 IL10 IL1B IL2 IL4 IL6
5
Cytokine Signaling in Immune system 67
Show member pathways
 13.48 CIITA CXCL8 IFNG IL10 IL1B IL2
6
PAK Pathway 65
Show member pathways
 13.4 CXCL8 IL10 IL1B IL2 IL4 IL6
7
IL-2 Pathway 65
Show member pathways
 13.34 HMGB1 IFNG IL1B IL2 IL4 TLR2
8
Toll-like Receptor Signaling Pathway 1 38
Show member pathways
 13.24 CXCL8 IFNG IL10 IL1B IL2 IL6
9
PI3K-Akt signaling pathway 38
Show member pathways
 13.06 IL2 IL4 IL6 TLR2 TLR4 TNF
10
Human cytomegalovirus infection 38
Show member pathways
 13.03 CXCL8 IL1B IL6 TLR2 TLR4 TNF
11
Allograft rejection 38 1
Show member pathways
 13.02 CIITA CXCL8 IFNG IL10 IL1B IL2
12
Pathways in cancer 38
12.94 CXCL8 EDNRA IFNG IL2 IL4 IL6
13
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.91 CXCL8 HMGB1 IFNG IL1B IL6 TLR4
14
NF-KappaB Family Pathway 65
Show member pathways
 12.86 IL1B IL2 IL6 LTA TLR2 TLR4
15
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 66
Show member pathways
 12.84 IL2 IL4 IL6 LTA TNF
16
Th17 cell differentiation 38
Show member pathways
 12.75 IFNG IL10 IL1B IL2 IL4 IL6
17
T cell receptor signaling pathway 38
Show member pathways
 12.74 IFNG IL10 IL1B IL2 IL4 IL6
18
NF-kappaB Signaling 4
12.74 CIITA IFNG IL10 IL1B IL2 IL4
19
Immune response IL-23 signaling pathway 23
Show member pathways
 12.73 IFNG IL10 IL1B IL2 IL6 TNF
20
Immune response NFAT in immune response 23
Show member pathways
 12.71 IFNG IL10 IL2 IL4 TNF
21
TRAF Pathway 65
Show member pathways
 12.69 IL1B LTA TLR2 TLR4 TNF
22
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.55 IFNG IL2 IL4 TNF
23
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.51 IFNG IL10 IL2 IL4 IL6
24
IL-17 Family Signaling Pathways 66
Show member pathways
 12.51 CXCL8 IFNG IL1B IL4 IL6 TLR2
25
Selenium Micronutrient Network 1
Show member pathways
 12.5 IFNG IL1B IL2 IL4 IL6 TNF
26
Toll Comparative Pathway 65
Show member pathways
 12.47 CXCL8 IFNG IL1B IL6 TLR4 TNF
27
Human T-cell leukemia virus 1 infection 38
12.41 IL2 IL6 LTA TNF
28
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.41 CXCL8 IFNG IL10 IL1B IL2 IL4
29
Toxoplasmosis 38
Show member pathways
 12.41 CIITA IFNG IL10 IL1B IL4 TLR2
30
Diseases associated with the TLR signaling cascade 67
Show member pathways
 12.4 CXCL8 IL6 TLR2 TLR4 TNF
31
IL-1 Family Signaling Pathways 66
Show member pathways
 12.37 CXCL8 IL1B IL6 TLR2 TNF
32
Tuberculosis 38
12.37 CIITA IFNG IL10 IL1B IL6 TLR2
33
C-type lectin receptor signaling pathway 38
Show member pathways
 12.36 IL10 IL1B IL2 IL6 TNF
34
Necroptosis 38
Show member pathways
 12.36 HMGB1 IFNG IL1B TLR4 TNF
35
Colorectal Cancer Metastasis 65
12.33 IFNG IL6 TLR2 TLR4 TNF
36
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.32 CXCL8 IL10 IL1B IL6 TNF
37
Bacterial infections in CF airways 23
Show member pathways
 12.3 CXCL8 IFNG IL1B IL4 IL6 TLR2
38
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.27 CXCL8 IL1B TLR2 TLR4 TREM1
39
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.24 CXCL8 IFNG IL10 IL1B IL2 IL4
40
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
12.19 IFNG IL10 IL2 IL4 IL6 TNF
41
Interleukin-4 and 13 signaling 67
12.18 CXCL8 IL10 IL1B IL4 IL6 TNF
42
MAPK Pathway 73
Show member pathways
 12.14 IL1B IL2 TLR2 TLR4
43
IL12-mediated signaling events 1
Show member pathways
 12.1 IFNG IL1B IL2 IL4
44
TNF signaling pathway 38
12.08 IL1B IL6 LTA TNF
45
NF-kappa B signaling pathway 38
12.08 CXCL8 IL1B LTA TLR4 TNF
46
Senescence and Autophagy in Cancer 1
12.06 CXCL8 IFNG IL1B IL6
47
Spinal Cord Injury 1
12.05 CXCL8 IFNG IL1B IL2 IL4 IL6
48
AGE-RAGE signaling pathway in diabetic complications 38
12.03 CXCL8 IL1B IL6 TNF
49
Hematopoietic cell lineage 38
12.02 IL1B IL4 IL6 TNF
50
Salmonella infection (KEGG) 38
12.01 CXCL8 IFNG IL1B IL6 TLR4
Sources

GO Terms for Toxic Shock Syndrome

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Cellular components related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 C1S CXCL8 HMGB1 IFNG IL10 IL1B
2 extracellular region GO:0005576 9.44 C1S CXCL8 HMGB1 IFNG IL10 IL1B

Biological processes related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.98 IL10 IL1B IL6 TNF
2 defense response to Gram-positive bacterium GO:0050830 9.96 IL6 LTA TLR2 TNF
3 positive regulation of JNK cascade GO:0046330 9.96 HMGB1 IL1B TLR4 TNF
4 positive regulation of inflammatory response GO:0050729 9.95 IL2 TLR2 TLR4 TNF
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.94 IFNG IL2 IL4 IL6
6 positive regulation of protein phosphorylation GO:0001934 9.93 IFNG IL1B IL2 TNF
7 cellular response to interferon-gamma GO:0071346 9.92 CIITA TLR2 TLR4
8 positive regulation of T cell proliferation GO:0042102 9.92 IL1B IL2 IL4 IL6
9 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 HMGB1 TLR4 TNF
10 regulation of insulin secretion GO:0050796 9.9 IFNG IL1B TNF
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.9 IFNG IL1B TLR4 TNF
12 positive regulation of tumor necrosis factor production GO:0032760 9.89 HMGB1 TLR2 TLR4
13 response to hypoxia GO:0001666 9.89 EDNRA LTA TLR2
14 positive regulation of cytosolic calcium ion concentration GO:0007204 9.89 EDNRA HMGB1 IL2
15 lipopolysaccharide-mediated signaling pathway GO:0031663 9.89 IL1B TLR2 TLR4 TNF
16 positive regulation of B cell proliferation GO:0030890 9.87 IL2 IL4 TLR4
17 toll-like receptor signaling pathway GO:0002224 9.87 HMGB1 TLR2 TLR4
18 positive regulation of interleukin-8 production GO:0032757 9.87 IL1B TLR2 TLR4 TNF
19 negative regulation of interferon-gamma production GO:0032689 9.86 HMGB1 IL10 TLR4
20 negative regulation of interleukin-6 production GO:0032715 9.86 IL10 TLR4 TNF
21 positive regulation of interleukin-12 production GO:0032735 9.86 HMGB1 IFNG TLR2 TLR4
22 negative regulation of neurogenesis GO:0050768 9.84 IL1B IL6 TNF
23 positive regulation of interleukin-10 production GO:0032733 9.84 HMGB1 TLR2 TLR4
24 positive regulation of chemokine production GO:0032722 9.83 IL6 TLR2 TLR4 TNF
25 humoral immune response GO:0006959 9.83 IFNG IL6 LTA TNF TREM1
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.82 IFNG IL1B TNF
27 negative regulation of growth of symbiont in host GO:0044130 9.81 IL10 LTA TNF
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.81 IL10 IL1B TNF
29 inflammatory response GO:0006954 9.81 CIITA CXCL8 HMGB1 IL10 IL1B IL6
30 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 HMGB1 IL1B TLR2 TLR4 TNF
31 response to molecule of bacterial origin GO:0002237 9.79 CXCL8 IL10 TLR2
32 positive regulation of interferon-gamma production GO:0032729 9.77 IL1B IL2 LTA TLR4 TNF
33 positive regulation of neuroinflammatory response GO:0150078 9.76 IL1B IL6 TNF
34 positive regulation of glial cell proliferation GO:0060252 9.76 IL1B IL6 LTA TNF
35 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.75 TLR2 TLR4
36 regulation of cytokine secretion GO:0050707 9.75 TLR2 TLR4
37 I-kappaB phosphorylation GO:0007252 9.74 TLR2 TLR4
38 negative regulation of interleukin-17 production GO:0032700 9.74 IFNG TLR4
39 positive regulation of immunoglobulin secretion GO:0051024 9.74 IL2 IL6
40 cellular response to lipoteichoic acid GO:0071223 9.74 TLR2 TLR4
41 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.73 TLR4 TNF
42 positive regulation of isotype switching to IgG isotypes GO:0048304 9.73 IL2 IL4
43 negative regulation of lipid storage GO:0010888 9.73 IL6 TNF
44 endothelial cell apoptotic process GO:0072577 9.73 IL10 TNF
45 positive regulation of chemokine biosynthetic process GO:0045080 9.73 IL1B TNF
46 positive regulation of interleukin-6 production GO:0032755 9.73 HMGB1 IL1B IL6 TLR2 TLR4 TNF
47 regulation of establishment of endothelial barrier GO:1903140 9.72 IL1B TNF
48 negative regulation of cytokine secretion involved in immune response GO:0002740 9.72 IL10 TNF
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.72 IFNG IL1B TNF
50 positive regulation of fever generation GO:0031622 9.71 IL1B TNF

Molecular functions related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 IL10 IL2 IL4 IL6
2 cytokine activity GO:0005125 9.32 CXCL8 HMGB1 IFNG IL10 IL1B IL2
3 lipopolysaccharide receptor activity GO:0001875 9.26 TLR2 TLR4
4 lipopolysaccharide binding GO:0001530 9.13 HMGB1 TLR2 TLR4
5 protein binding GO:0005515 10.22 C1S CIITA CXCL8 EDNRA HMGB1 IFNG
Sources

Sources for Toxic Shock Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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