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TSS
MCID: TXC005
MIFTS: 61

Toxic Shock Syndrome (TSS)

Categories: Infectious diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Toxic Shock Syndrome

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MalaCards integrated aliases for Toxic Shock Syndrome:

Name: Toxic Shock Syndrome 12 76 55 15 73
Staphylococcal Toxic Shock Syndrome 73
Shock, Septic 44
Toxic Shock 12
Tss 12

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:14115
ICD10 33 A48.3 R57.2
ICD9CM 35 040.82
MeSH 44 D012772
NCIt 50 C35498
SNOMED-CT 68 18504008
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Summaries for Toxic Shock Syndrome

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Disease Ontology : 12 A commensal bacterial infectious disease that results in infection, has material basis in Streptococcus pyogenes or has material basis in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has symptom fever, has symptom rash, has symptom hypotension, has symptom multiorgan failure, has symptom desquamation, has symptom vomiting, has symptom diarrhea, has symptom headache, and has symptom nonfocal neurologic abnormalities.

MalaCards based summary : Toxic Shock Syndrome, also known as staphylococcal toxic shock syndrome, is related to staphylococcal toxic shock syndrome and streptococcal toxic-shock syndrome, and has symptoms including hypotension, fever and vomiting. An important gene associated with Toxic Shock Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Amoxicillin and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and monocytes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

CDC : 3 Educational Materials

Wikipedia : 76 Toxic shock syndrome (TSS) is a condition caused by bacterial toxins. Symptoms may include fever, rash,... more...

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Related Diseases for Toxic Shock Syndrome

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Diseases related to Toxic Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 464)
# Related Disease Score Top Affiliating Genes
1 staphylococcal toxic shock syndrome 34.2 CIITA HMGB1 IFNG IL1B TNF
2 streptococcal toxic-shock syndrome 33.5 C1S CXCL8 IL2 IL6 LTA MYOM2
3 fasciitis 31.0 CXCL8 IL6 TNF
4 burns 30.7 IL1B SERPINC1 TNF
5 necrotizing fasciitis 30.6 CXCL8 IL2 IL6 LTA MYOM2
6 pharyngitis 30.4 CXCL8 IL1B MYOM2
7 kawasaki disease 30.3 IL10 IL6 TNF
8 mastitis 30.3 CXCL8 IL6 TLR2
9 endomyocardial fibrosis 30.2 IL10 IL4 TNF
10 vaginitis 30.1 CXCL8 IL1B IL6
11 reactive arthritis 30.0 IFNG IL10 TNF
12 arthritis 30.0 CIITA CXCL8 IFNG IL10 IL1B IL6
13 purpura 30.0 IL6 SERPINC1 TNF
14 peritonitis 30.0 CXCL8 IL10 IL1B IL6 TLR2 TNF
15 arteries, anomalies of 30.0 IL1B IL6 SERPINC1 TNF
16 endometritis 29.9 IL1B IL6 TNF
17 sudden infant death syndrome 29.9 IL10 IL1B IL6 TNF
18 scleritis 29.9 IFNG IL4 TNF
19 rheumatic fever-related antigen 29.8 MYOM2 TLR2
20 pericarditis 29.8 IFNG IL1B IL6 TNF
21 herpes zoster 29.8 IFNG IL10 IL2
22 infective endocarditis 29.8 IL6 TLR2 TNF
23 severe acute respiratory syndrome 29.7 CXCL8 IFNG TNF
24 acute pancreatitis 29.7 CXCL8 IL10 IL6
25 cardiogenic shock 29.7 IL6 TNF
26 endocarditis 29.7 CXCL8 IL10 IL6 SERPINC1 TLR2 TNF
27 hemophagocytic lymphohistiocytosis 29.7 CXCL8 IFNG IL10 TNF
28 measles 29.7 IFNG IL2 IL4 IL6 TLR2
29 noonan syndrome 1 29.7 CXCL8 IL1B IL2 IL6 TNF
30 plasmodium vivax malaria 29.6 IFNG IL10 IL6 TNF
31 myeloma, multiple 29.6 CXCL8 IL2 IL6 MYOM2 TNF
32 rheumatic fever 29.6 IL10 IL2 IL6 MYOM2 TNF
33 viral infectious disease 29.5 CXCL8 IFNG IL10 IL1B IL2 IL4
34 osteomyelitis 29.5 CXCL8 IFNG IL10 IL1B IL6 TNF
35 septic arthritis 29.4 CXCL8 TLR2 TLR4
36 meningitis 29.4 CXCL8 IFNG IL10 IL1B IL6 TLR2
37 chorioamnionitis 29.4 CXCL8 IL1B IL6 TLR4 TNF
38 prosthetic joint infection 29.4 IL1B TLR2 TLR4
39 psoriasis 29.2 CXCL8 IFNG IL10 IL1B IL2 IL4
40 tonsillitis 29.2 CXCL8 IFNG IL1B IL2 IL4 IL6
41 pneumonia 29.2 CXCL8 IL10 IL1B IL6 TLR2 TLR4
42 trypanosomiasis 29.2 CXCL8 IFNG IL10 IL1B IL2 IL4
43 aspergillosis 28.9 IFNG IL10 IL4 TLR2 TLR4 TNF
44 dermatitis, atopic 28.9 CXCL8 IFNG IL10 IL2 IL4 TLR2
45 rheumatoid arthritis 28.5 CIITA CXCL8 HMGB1 IFNG IL10 IL1B
46 malaria 27.9 CXCL8 IFNG IL10 IL1B IL2 IL4
47 systemic lupus erythematosus 27.7 C1S CXCL8 HMGB1 IFNG IL10 IL1B
48 staphylococcal scarlet fever 11.6
49 clostridium sordellii infection 11.6
50 oral tuberculosis 10.3 IL2 TNF

Graphical network of the top 20 diseases related to Toxic Shock Syndrome:



Diseases related to Toxic Shock Syndrome
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Symptoms & Phenotypes for Toxic Shock Syndrome

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Symptoms:

12
  • • hypotension
  • • fever
  • • vomiting
  • • diarrhea
  • • headache
  • • desquamation
  • • rash
  • • multiorgan failure
  • • nonfocal neurologic abnormalities

UMLS symptoms related to Toxic Shock Syndrome:


shock without mention of trauma

GenomeRNAi Phenotypes related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CXCL8 IL10 IL1B IL2 LTA TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CXCL8 IL10 IL1B IL2 LTA TNF

MGI Mouse Phenotypes related to Toxic Shock Syndrome:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 CIITA IFNG IL10 IL1B IL2 IL4
2 homeostasis/metabolism MP:0005376 10.29 CIITA IFNG IL10 IL1B IL2 IL4
3 immune system MP:0005387 10.27 CIITA IFNG IL10 IL1B IL2 IL4
4 cardiovascular system MP:0005385 10.24 IFNG IL10 IL1B IL2 IL6 LTA
5 endocrine/exocrine gland MP:0005379 10.16 CIITA IFNG IL10 IL2 IL4 IL6
6 digestive/alimentary MP:0005381 10.13 IFNG IL10 IL2 IL4 IL6 TLR2
7 liver/biliary system MP:0005370 10.1 IFNG IL10 IL2 IL4 IL6 LTA
8 integument MP:0010771 10.03 IFNG IL10 IL1B IL4 IL6 TLR2
9 neoplasm MP:0002006 10.02 IFNG IL10 IL1B IL2 IL6 TLR2
10 nervous system MP:0003631 10.02 IFNG IL10 IL1B IL4 IL6 LTA
11 reproductive system MP:0005389 9.86 IFNG IL10 IL2 IL4 IL6 SERPINC1
12 respiratory system MP:0005388 9.81 IFNG IL10 IL2 IL4 IL6 LTA
13 skeleton MP:0005390 9.7 CIITA IFNG IL10 IL1B IL4 IL6
14 vision/eye MP:0005391 9.28 IFNG IL10 IL2 IL4 IL6 LTA
Sources

Drugs & Therapeutics for Toxic Shock Syndrome

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Drugs for Toxic Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
3
Rifampicin Approved Phase 4 13292-46-1 5458213 5381226
4
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
5 Immunologic Factors Phase 4,Phase 2,Phase 1
6 Rho(D) Immune Globulin Phase 4,Phase 2
7 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
8 gamma-Globulins Phase 4,Phase 2
9 Antibodies Phase 4,Phase 2
10 Immunoglobulins Phase 4,Phase 2
11 Immunoglobulins, Intravenous Phase 4,Phase 2
12 Anti-Bacterial Agents Phase 4,Phase 3
13 Anti-Infective Agents Phase 4,Phase 3
14 Clavulanic Acids Phase 4
15 Antibiotics, Antitubercular Phase 4
16 proline Phase 4
17 beta-Lactamase Inhibitors Phase 4
18 Clindamycin phosphate Phase 4
19 Clindamycin palmitate Phase 4
20 Amoxicillin-Potassium Clavulanate Combination Phase 4
21 Vaccines Phase 2,Phase 1
22
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
23
Iron Approved Phase 1 7439-89-6 23925
24
Imidazole Experimental, Investigational Phase 1 288-32-4 795
25 Anti-Ulcer Agents Phase 1
26 Antacids Phase 1
27 Adjuvants, Immunologic Phase 1
28 Gastrointestinal Agents Phase 1
29 Monophosphoryl lipid A Phase 1
30 Adrenergic Antagonists
31 Neurotransmitter Agents
32 Adrenergic beta-Antagonists
33 Adrenergic Agents
34 methicillin

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Intravenous Immunoglobulins (IVIG) in Toxic Shock Syndromes in Children Not yet recruiting NCT02899702 Phase 4 PRIVIGEN (CSL Behring);Albumin
2 De-escalation of Empirical Antimicrobial Therapy Study in Severe Sepsis Completed NCT01626612 Phase 3
3 Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot Study Unknown status NCT02219165 Phase 2 Intravenous human immunoglobulin;Albumin
4 Clinical Trial of the BioMed rTSST‐1 Variant Vaccine in Healthy Adults Recruiting NCT02814708 Phase 2
5 Phase I STEBVax in Healthy Adults Completed NCT00974935 Phase 1 Aluminum hydroxide
6 Amendment of rTSST-1 Variant Vaccine Phase 1 Clinical Trial Completed NCT02971670 Phase 1
7 rTSST-1 Variant Vaccine Phase 1 First-in-man Trail Completed NCT02340338 Phase 1
8 Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy Adults Completed NCT01717950 Phase 1
9 Role of Beta-blockers in the Prevention on the Arisen of a Severe Sepsis (TESS) Completed NCT01606631
10 Pediatric Immune Response to Infectious Shock Completed NCT02848144 Not Applicable
11 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
12 Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus Completed NCT01141101
13 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
14 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128
15 Cups or Cash for Girls Trial to Reduce Sexual and Reproductive Harm and School Dropout Recruiting NCT03051789 Not Applicable

Search NIH Clinical Center for Toxic Shock Syndrome

Cochrane evidence based reviews: shock, septic

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Genetic Tests for Toxic Shock Syndrome

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Anatomical Context for Toxic Shock Syndrome

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MalaCards organs/tissues related to Toxic Shock Syndrome:

41
T Cells, Skin, Monocytes, Heart, Colon, Bone, Eye
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Publications for Toxic Shock Syndrome

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Articles related to Toxic Shock Syndrome:

(show top 50) (show all 1045)
# Title Authors Year
1
Contribution of toxic shock syndrome toxin-1 to systemic inflammation investigated by a mouse model of cervicovaginal infection with Staphylococcus aureus. ( 29980843 )
2018
2
The effect of vaginal microbial communities on colonization by Staphylococcus aureus with the gene for toxic shock syndrome toxin 1 (TSST-1): a case-control study. ( 29762733 )
2018
3
Clinical and Molecular Epidemiology of Staphylococcal Toxic Shock Syndrome in the United Kingdom. ( 29350159 )
2018
4
Draft Genome Sequence of Streptococcus suis Strain SsRC-1, a Human Isolate from a Fatal Case of Toxic Shock Syndrome. ( 29773639 )
2018
5
Polyspecific intravenous immunoglobulin in clindamycin-treated patients with streptococcal toxic shock syndrome: a systematic review and meta-analysis. ( 29788397 )
2018
6
The Evaluation and Management of Toxic Shock Syndrome in the Emergency Department: A Review of the Literature. ( 29366615 )
2018
7
Periocular Necrotizing Fasciitis with Toxic Shock Syndrome. ( 29928226 )
2018
8
RS3PE syndrome developing during the course of probable toxic shock syndrome: a case report. ( 29653519 )
2018
9
Epidemiology and Clinical Relevance of Toxic Shock Syndrome in US Children. ( 29601458 )
2018
10
Molecular characterization and antibiotic resistance of Streptococcus dysgalactiae subspecies equisimilis isolated from patients with streptococcal toxic shock syndrome. ( 29107650 )
2018
11
Frequency of enterotoxins, toxic shock syndrome toxin-1, and biofilm formation genes in Staphylococcus aureus isolates from cows with mastitis in the Northeast of Brazil. ( 29429115 )
2018
12
Fulminant streptococcal toxic shock syndrome. ( 29741523 )
2018
13
Innate immune responses following Kawasaki disease and toxic shock syndrome. ( 29447181 )
2018
14
Successful Treatment of Streptococcal Toxic Shock Syndrome with Both Diffuse Peritonitis and Necrotizing Fasciitis. ( 30510834 )
2018
15
Uncommon cause of pelvic inflammatory disease leading to toxic shock syndrome. ( 30249728 )
2018
16
Streptococcal toxic shock syndrome with primary group A streptococcus peritonitis in a healthy female. ( 30356961 )
2018
17
Streptococcal toxic shock syndrome - a life-threatening condition caused by various streptococcal species. ( 30126285 )
2018
18
Successful treatment of out-of-hospital cardiopulmonary arrest due to streptococcal toxic shock syndrome - effectiveness of extracorporeal membrane oxygenation and the rapid antigen group A streptococcus test: a case report. ( 30170621 )
2018
19
Streptococcal toxic shock syndrome in the intensive care unit. ( 30225523 )
2018
20
Streptococcal toxic shock syndrome in a returning traveller. ( 30369302 )
2018
21
Epidemiology of toxic shock syndrome toxin-1 harboring Staphylococcus aureus obtained from clinical samples in Iran: A Systematic Review and Meta-analysis. ( 30062367 )
2018
22
Survival from Clostridium toxic shock syndrome: Case report and review of the literature. ( 30081323 )
2018
23
Clinical Manifestations and Bacterial Genomic Analysis of Group A Streptococcus Strains That Cause Pediatric Toxic Shock Syndrome. ( 30085250 )
2018
24
The use of etanercept for treatment of toxic epidermal necrolysis when toxic shock syndrome is in the differential. ( 30175438 )
2018
25
Carriage of the Toxic Shock Syndrome Toxin Gene by Contemporary Community-Associated Staphylococcus aureus Isolates. ( 30285124 )
2018
26
Postpartum Methicillin-Resistant Staphylococcus aureus Toxic Shock Syndrome Caused by a Perineal Infection. ( 30363971 )
2018
27
Streptococcus pyogenes bacteremia and toxic shock syndrome related to Strongyloides stercoralis hyperinfection: a case report. ( 30463627 )
2018
28
Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes. ( 29254479 )
2017
29
Complete Genome Sequence and Comparative Genomics of a Streptococcus pyogenes emm3 Strain M3-b isolated from a Japanese Patient with Streptococcal Toxic Shock Syndrome. ( 28698738 )
2017
30
Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. ( 28580155 )
2017
31
Group A Streptococcal Peritonitis and Toxic Shock Syndrome in a Postmenopausal Woman. ( 28824068 )
2017
32
Macro- and Microvascular Parameters Following Toxic Shock Syndrome. ( 29112091 )
2017
33
Toxic shock syndrome, tampons and laboratory standard-setting. ( 28536130 )
2017
34
Rare presentation of necrotising fasciitis and streptococcal toxic shock syndrome by group A streptococcus. ( 28954758 )
2017
35
Post-partum streptococcal toxic shock syndrome associated with necrotizing fasciitis. ( 28725564 )
2017
36
Toxic shock syndrome in paediatric thermal injuries: A case series and systematic literature review. ( 28867411 )
2017
37
Case of toxic shock syndrome triggered by negative-pressure wound therapy. ( 28862320 )
2017
38
Toxic Shock Syndrome: Still a Timely Diagnosis. ( 29040243 )
2017
39
Erratum: Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. ( 28721224 )
2017
40
Infective Endocarditis Associated with Streptococcal Toxic Shock Syndrome due to <i>Streptococcus dysgalactiae</i> subsp. <i>equisimilis</i> Infection in a Hemodialysis Patient. ( 29457020 )
2017
41
Vaccine against toxic shock syndrome in a first-in-man clinical trial. ( 27918218 )
2017
42
Toxic shock syndrome due to community-acquired methicillin-resistant Staphylococcus aureus infection: Two case reports and a literature review in Japan. ( 28491813 )
2017
43
HLA-DR polymorphisms influence in vivo responses to staphylococcal toxic shock syndrome toxin-1 in a transgenic mouse model. ( 27863161 )
2017
44
Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid. ( 28299216 )
2017
45
Prevalence, comorbidities and mortality of toxic shock syndrome in United States children and adults. ( 28892185 )
2017
46
Septic miscarriage with toxic shock syndrome and disseminated intravascular coagulation (DIC): The role of surgery, recombinant activated factor VII and intravenous immunoglobulin (IVIG). ( 29308782 )
2017
47
Streptococcal toxic-shock syndrome due to Streptococcus dysgalactiae subspecies equisimilis in breast cancer-related lymphedema: a case report. ( 28705211 )
2017
48
Inverse relationship between toxic shock syndrome toxin-1 antibodies and interferon-I^ and interleukin-6 in peripheral blood mononuclear cells from patients with pediatric tonsillitis caused by Staphylococcus aureus. ( 28483238 )
2017
49
A 2-year-old boy with circulatory failure owing to streptococcal toxic shock syndrome: case report. ( 28426384 )
2017
50
Toxic shock syndrome - the seven Rs of management and treatment. ( 28646955 )
2017
Sources

Variations for Toxic Shock Syndrome

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ClinVar genetic disease variations for Toxic Shock Syndrome:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TNF TNF, -308G-A single nucleotide variant risk factor
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Expression for Toxic Shock Syndrome

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Search GEO for disease gene expression data for Toxic Shock Syndrome.
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Pathways for Toxic Shock Syndrome

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Pathways related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.12 C1S CIITA CXCL8 HMGB1 IFNG IL10
2
PEDF Induced Signaling 64
Show member pathways
 13.77 CXCL8 IFNG IL10 IL1B IL2 IL4
3
TGF-Beta Pathway 64
Show member pathways
 13.63 CXCL8 IFNG IL10 IL1B IL2 IL4
4
Akt Signaling 64
Show member pathways
 13.53 CXCL8 IL10 IL1B IL2 IL4 IL6
5
Cytokine Signaling in Immune system 66
Show member pathways
 13.48 CIITA CXCL8 IFNG IL10 IL1B IL2
6
PAK Pathway 64
Show member pathways
 13.4 CXCL8 IL10 IL1B IL2 IL4 IL6
7
IL-2 Pathway 64
Show member pathways
 13.34 HMGB1 IFNG IL1B IL2 IL4 TLR2
8
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13.16 CXCL8 IFNG IL10 IL1B IL2 IL6
9
Human cytomegalovirus infection 37
Show member pathways
 13.12 CXCL8 IL1B IL6 TLR2 TLR4 TNF
10
PI3K-Akt signaling pathway 37
Show member pathways
 13.07 IL2 IL4 IL6 TLR2 TLR4 TNF
11
Allograft rejection 1 37
Show member pathways
 13.02 CIITA CXCL8 IFNG IL10 IL1B IL2
12
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.91 CXCL8 HMGB1 IFNG IL1B IL6 TLR4
13
Pathways in cancer 37
12.88 CXCL8 IFNG IL2 IL4 IL6
14
NF-KappaB Family Pathway 64
Show member pathways
 12.86 IL1B IL2 IL6 LTA TLR2 TLR4
15
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 65
Show member pathways
 12.84 IL2 IL4 IL6 LTA TNF
16
Influenza A 37
Show member pathways
 12.8 CIITA CXCL8 IFNG IL1B IL2 IL4
17
Th17 cell differentiation 37
Show member pathways
 12.76 IFNG IL10 IL1B IL2 IL4 IL6
18
NF-kappaB Signaling 4
12.74 CIITA IFNG IL10 IL1B IL2 IL4
19
Immune response IL-23 signaling pathway 22
Show member pathways
 12.72 IFNG IL10 IL1B IL2 IL6 TNF
20
Immune response NFAT in immune response 22
Show member pathways
 12.71 IFNG IL10 IL2 IL4 TNF
21
TRAF Pathway 64
Show member pathways
 12.69 IL1B LTA TLR2 TLR4 TNF
22
T cell receptor signaling pathway 37
Show member pathways
 12.61 IFNG IL10 IL1B IL2 IL4 IL6
23
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.55 IFNG IL2 IL4 TNF
24
IL-17 Family Signaling Pathways 65
Show member pathways
 12.52 CXCL8 IFNG IL1B IL4 IL6 TLR2
25
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.51 IFNG IL10 IL2 IL4 IL6
26
Selenium Micronutrient Network 1
Show member pathways
 12.5 IFNG IL1B IL2 IL4 IL6 TNF
27
Human T-cell leukemia virus 1 infection 37
12.47 IL2 IL6 LTA TNF
28
Toll Comparative Pathway 64
Show member pathways
 12.47 CXCL8 IFNG IL1B IL6 TLR4 TNF
29
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.42 CXCL8 IFNG IL10 IL1B IL2 IL4
30
Toxoplasmosis 37
Show member pathways
 12.42 CIITA IFNG IL10 IL1B IL4 TLR2
31
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.4 CXCL8 IL6 TLR2 TLR4 TNF
32
Tuberculosis 37
12.38 CIITA IFNG IL10 IL1B IL6 TLR2
33
IL-1 Family Signaling Pathways 65
Show member pathways
 12.37 CXCL8 IL1B IL6 TLR2 TNF
34
C-type lectin receptor signaling pathway 37
Show member pathways
 12.36 IL10 IL1B IL2 IL6 TNF
35
Necroptosis 37
Show member pathways
 12.36 HMGB1 IFNG IL1B TLR4 TNF
36
Colorectal Cancer Metastasis 64
12.33 IFNG IL6 TLR2 TLR4 TNF
37
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.33 CXCL8 IL10 IL1B IL6 TNF
38
Bacterial infections in CF airways 22
Show member pathways
 12.31 CXCL8 IFNG IL1B IL4 IL6 TLR2
39
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 12.27 CXCL8 IL1B TLR2 TLR4 TREM1
40
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.24 CXCL8 IFNG IL10 IL1B IL2 IL4
41
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
12.2 IFNG IL10 IL2 IL4 IL6 TNF
42
Interleukin-4 and 13 signaling 66
12.18 CXCL8 IL10 IL1B IL4 IL6 TNF
43
MAPK Pathway 72
Show member pathways
 12.14 IL1B IL2 TLR2 TLR4
44
IL12-mediated signaling events 1
Show member pathways
 12.1 IFNG IL1B IL2 IL4
45
Spinal Cord Injury 1
12.09 CXCL8 IFNG IL1B IL2 IL4 IL6
46
TNF signaling pathway 37
12.08 IL1B IL6 LTA TNF
47
NF-kappa B signaling pathway 37
12.07 CXCL8 IL1B LTA TLR4 TNF
48
Senescence and Autophagy in Cancer 1
12.06 CXCL8 IFNG IL1B IL6
49
AGE-RAGE signaling pathway in diabetic complications 37
12.03 CXCL8 IL1B IL6 TNF
50
Hematopoietic cell lineage 37
12.02 IL1B IL4 IL6 TNF
Sources

GO Terms for Toxic Shock Syndrome

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Cellular components related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 C1S CXCL8 HMGB1 IFNG IL10 IL1B
2 cell surface GO:0009986 9.55 CIITA HMGB1 TLR2 TLR4 TNF
3 extracellular region GO:0005576 9.44 C1S CXCL8 HMGB1 IFNG IL10 IL1B

Biological processes related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.97 IL10 IL1B IL6 TNF
2 defense response to Gram-positive bacterium GO:0050830 9.96 IL6 LTA TLR2 TNF
3 positive regulation of JNK cascade GO:0046330 9.96 HMGB1 IL1B TLR4 TNF
4 positive regulation of inflammatory response GO:0050729 9.95 IL2 TLR2 TLR4 TNF
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.94 IFNG IL2 IL4 IL6
6 cellular response to interferon-gamma GO:0071346 9.92 CIITA TLR2 TLR4
7 positive regulation of T cell proliferation GO:0042102 9.92 IL1B IL2 IL4 IL6
8 response to glucocorticoid GO:0051384 9.91 HMGB1 IL10 IL1B IL6 TNF
9 regulation of insulin secretion GO:0050796 9.9 IFNG IL1B TNF
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.9 IFNG IL1B TLR4 TNF
11 positive regulation of tumor necrosis factor production GO:0032760 9.89 HMGB1 TLR2 TLR4
12 lipopolysaccharide-mediated signaling pathway GO:0031663 9.88 IL1B TLR2 TLR4 TNF
13 positive regulation of B cell proliferation GO:0030890 9.87 IL2 IL4 TLR4
14 toll-like receptor signaling pathway GO:0002224 9.87 HMGB1 TLR2 TLR4
15 positive regulation of interleukin-8 production GO:0032757 9.87 IL1B TLR2 TLR4 TNF
16 negative regulation of interferon-gamma production GO:0032689 9.86 HMGB1 IL10 TLR4
17 negative regulation of interleukin-6 production GO:0032715 9.86 IL10 TLR4 TNF
18 positive regulation of interleukin-12 production GO:0032735 9.86 HMGB1 IFNG TLR2 TLR4
19 positive regulation of interferon-beta production GO:0032728 9.85 HMGB1 TLR2 TLR4
20 negative regulation of neurogenesis GO:0050768 9.84 IL1B IL6 TNF
21 positive regulation of interleukin-10 production GO:0032733 9.84 HMGB1 TLR2 TLR4
22 positive regulation of chemokine production GO:0032722 9.84 IL6 TLR2 TLR4 TNF
23 humoral immune response GO:0006959 9.83 IFNG IL6 LTA TNF TREM1
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.82 IFNG IL1B TNF
25 negative regulation of growth of symbiont in host GO:0044130 9.81 IL10 LTA TNF
26 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.81 IL10 IL1B TNF
27 inflammatory response GO:0006954 9.81 CIITA CXCL8 HMGB1 IL10 IL1B IL6
28 positive regulation of glial cell proliferation GO:0060252 9.8 IL1B IL6 LTA TNF
29 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 HMGB1 IL1B TLR2 TLR4 TNF
30 response to molecule of bacterial origin GO:0002237 9.79 CXCL8 IL10 TLR2
31 positive regulation of neuroinflammatory response GO:0150078 9.77 IL1B IL6 TNF
32 positive regulation of interferon-gamma production GO:0032729 9.77 IL1B IL2 LTA TLR4 TNF
33 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.75 TLR2 TLR4
34 positive regulation of interferon-alpha production GO:0032727 9.74 HMGB1 TLR4
35 regulation of cytokine secretion GO:0050707 9.74 TLR2 TLR4
36 I-kappaB phosphorylation GO:0007252 9.74 TLR2 TLR4
37 negative regulation of interleukin-17 production GO:0032700 9.74 IFNG TLR4
38 positive regulation of immunoglobulin secretion GO:0051024 9.74 IL2 IL6
39 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.74 HMGB1 IL1B
40 cellular response to lipoteichoic acid GO:0071223 9.74 TLR2 TLR4
41 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.73 TLR4 TNF
42 positive regulation of isotype switching to IgG isotypes GO:0048304 9.73 IL2 IL4
43 negative regulation of lipid storage GO:0010888 9.73 IL6 TNF
44 endothelial cell apoptotic process GO:0072577 9.73 IL10 TNF
45 positive regulation of interleukin-6 production GO:0032755 9.73 HMGB1 IL1B IL6 TLR2 TLR4 TNF
46 positive regulation of chemokine biosynthetic process GO:0045080 9.72 IL1B TNF
47 regulation of establishment of endothelial barrier GO:1903140 9.72 IL1B TNF
48 negative regulation of cytokine secretion involved in immune response GO:0002740 9.72 IL10 TNF
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.72 IFNG IL1B TNF
50 positive regulation of fever generation GO:0031622 9.71 IL1B TNF

Molecular functions related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 IL10 IL2 IL4 IL6
2 cytokine activity GO:0005125 9.32 CXCL8 HMGB1 IFNG IL10 IL1B IL2
3 lipopolysaccharide receptor activity GO:0001875 9.26 TLR2 TLR4
4 lipopolysaccharide binding GO:0001530 9.13 HMGB1 TLR2 TLR4
5 protein binding GO:0005515 10.2 C1S CIITA CXCL8 HMGB1 IFNG IL10
Sources

Sources for Toxic Shock Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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