Aliases & Classifications for Toxic Shock Syndrome

MalaCards integrated aliases for Toxic Shock Syndrome:

Name: Toxic Shock Syndrome 12 76 55 15 73
Staphylococcal Toxic Shock Syndrome 73
Shock, Septic 44
Toxic Shock 12
Tss 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14115
ICD10 33 A48.3 R57.2
ICD9CM 35 040.82
MeSH 44 D012772
NCIt 50 C35498
SNOMED-CT 68 18504008

Summaries for Toxic Shock Syndrome

Disease Ontology : 12 A commensal bacterial infectious disease that results in infection, has material basis in Streptococcus pyogenes or has material basis in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has symptom fever, has symptom rash, has symptom hypotension, has symptom multiorgan failure, has symptom desquamation, has symptom vomiting, has symptom diarrhea, has symptom headache, and has symptom nonfocal neurologic abnormalities.

MalaCards based summary : Toxic Shock Syndrome, also known as staphylococcal toxic shock syndrome, is related to staphylococcal toxic shock syndrome and streptococcal toxic-shock syndrome, and has symptoms including fever, rash and hypotension. An important gene associated with Toxic Shock Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Rifampicin and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and colon, and related phenotypes are hematopoietic system and homeostasis/metabolism

CDC : 3 Get Ahead of Sepsis

Wikipedia : 76 Toxic shock syndrome (TSS) is a condition caused by bacterial toxins. Symptoms may include fever, rash,... more...

Related Diseases for Toxic Shock Syndrome

Diseases related to Toxic Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 414)
# Related Disease Score Top Affiliating Genes
1 staphylococcal toxic shock syndrome 33.9 CIITA HMGB1 IFNG IL1B TNF
2 streptococcal toxic-shock syndrome 32.4 C1S CXCL8 IL2 IL6 LTA MYOM2
3 fasciitis 31.5 CXCL8 IL6 TNF
4 burns 31.4 IL1B SERPINC1 TNF
5 vaginitis 31.3 CXCL8 IL1B IL6
6 pharyngitis 30.6 CXCL8 IL1B MYOM2
7 necrotizing fasciitis 30.5 CXCL8 IL2 IL6 LTA MYOM2
8 pericarditis 30.5 IL1B IL6 TNF
9 kawasaki disease 30.4 IL10 IL6 TNF
10 arteries, anomalies of 30.1 IL1B IL6 SERPINC1 TNF
11 mastitis 30.1 CXCL8 IL6 TLR2
12 herpes zoster 30.0 IFNG IL10 IL2
13 infective endocarditis 30.0 IL6 TLR2 TNF
14 sudden infant death syndrome 29.9 IL10 IL1B IL6 TNF
15 reactive arthritis 29.9 IFNG IL10 IL6 TNF
16 acute pancreatitis 29.8 CXCL8 IL10 IL6
17 hemophagocytic lymphohistiocytosis 29.7 CXCL8 IFNG IL10 TNF
18 rheumatic fever 29.5 IL2 MYOM2 TLR2 TNF
19 myeloma, multiple 29.5 CXCL8 IL2 IL6 MYOM2 TNF
20 peritonitis 29.3 CXCL8 IL10 IL1B IL6 TLR2 TNF
21 measles 29.0 IFNG IL2 IL4 IL6 TLR2
22 arthritis 28.8 CIITA CXCL8 IFNG IL10 IL1B IL6
23 endocarditis 28.7 CXCL8 IL10 IL6 SERPINC1 TLR2 TNF
24 chorioamnionitis 28.7 CXCL8 IL1B IL6 TLR4 TNF
25 meningitis 28.3 CXCL8 IFNG IL10 IL1B IL6 TLR2
26 tonsillitis 28.3 CXCL8 IFNG IL1B IL2 IL4 IL6
27 dermatitis, atopic 28.1 CXCL8 IFNG IL10 IL2 IL4 TLR2
28 psoriasis 27.8 CXCL8 IFNG IL10 IL1B IL2 IL4
29 aspergillosis 27.7 IFNG IL10 IL4 TLR2 TLR4
30 systemic lupus erythematosus 26.7 C1S HMGB1 IFNG IL10 IL2 IL4
31 pneumonia 26.6 CXCL8 IL10 IL1B IL6 TLR2 TLR4
32 rheumatoid arthritis 24.9 CIITA CXCL8 HMGB1 IFNG IL10 IL1B
33 clostridium sordellii infection 11.4
34 staphylococcal scarlet fever 11.4
35 oral tuberculosis 11.0 IL2 TNF
36 juvenile spondyloarthropathy 10.9 IL2 LTA
37 scorpion envenomation 10.9 IL6 TNF
38 systemic onset juvenile idiopathic arthritis 10.8 IL1B TNF
39 leukomalacia 10.8 IL6 TNF
40 punctate inner choroidopathy 10.8 IL10 TNF
41 laryngitis 10.8 IL1B IL6 TNF
42 null-cell leukemia 10.8 IL6 LTA TNF
43 acute vascular insufficiency of intestine 10.8 IL1B IL6 TNF
44 central nervous system vasculitis 10.8 IL1B IL6 TNF
45 stachybotrys chartarum 10.8 IL1B IL6 TNF
46 angioimmunoblastic lymphadenopathy with dysproteinemia 10.8 IL6 TNF
47 mycoplasmal pneumonia 10.8 IFNG IL4
48 endometritis 10.7 IL1B IL6 TNF
49 uremic pruritus 10.7 IL1B IL2 IL6
50 burning mouth syndrome 10.7 IL2 IL6 TNF

Graphical network of the top 20 diseases related to Toxic Shock Syndrome:



Diseases related to Toxic Shock Syndrome

Symptoms & Phenotypes for Toxic Shock Syndrome

Symptoms:

12
  • fever
  • rash
  • hypotension
  • multiorgan failure
  • desquamation
  • vomiting
  • diarrhea
  • headache
  • nonfocal neurologic abnormalities

UMLS symptoms related to Toxic Shock Syndrome:


shock without mention of trauma

MGI Mouse Phenotypes related to Toxic Shock Syndrome:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 CIITA IFNG IL10 IL1B IL2 IL4
2 homeostasis/metabolism MP:0005376 10.29 CIITA IFNG IL10 IL1B IL2 IL4
3 immune system MP:0005387 10.27 LTA SERPINC1 TLR2 TLR4 TNF TREM1
4 cardiovascular system MP:0005385 10.24 IFNG IL10 IL1B IL2 IL6 LTA
5 endocrine/exocrine gland MP:0005379 10.16 CIITA IFNG IL10 IL2 IL4 IL6
6 digestive/alimentary MP:0005381 10.13 TNF IFNG IL10 IL2 IL4 IL6
7 liver/biliary system MP:0005370 10.1 IFNG IL10 IL2 IL4 IL6 LTA
8 integument MP:0010771 10.03 IFNG IL10 IL1B IL4 IL6 TLR2
9 neoplasm MP:0002006 10.02 IFNG IL10 IL1B IL2 IL6 TLR2
10 nervous system MP:0003631 10.02 IFNG IL10 IL1B IL4 IL6 LTA
11 reproductive system MP:0005389 9.86 IFNG IL10 IL2 IL4 IL6 SERPINC1
12 respiratory system MP:0005388 9.81 IFNG IL10 IL2 IL4 IL6 LTA
13 skeleton MP:0005390 9.7 CIITA IFNG IL10 IL1B IL4 IL6
14 vision/eye MP:0005391 9.28 IFNG IL10 IL2 IL4 IL6 LTA

Drugs & Therapeutics for Toxic Shock Syndrome

Drugs for Toxic Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifampicin Approved Phase 4 13292-46-1 5458213 5381226
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
3
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
4
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
5 Rho(D) Immune Globulin Phase 4,Phase 2
6 gamma-Globulins Phase 4,Phase 2
7 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
8 Antibodies Phase 4,Phase 2
9 Immunoglobulins Phase 4,Phase 2
10 Immunoglobulins, Intravenous Phase 4,Phase 2
11 Anti-Bacterial Agents Phase 4,Phase 3
12 Anti-Infective Agents Phase 4,Phase 3
13 Clavulanic Acid Phase 4
14 Clindamycin palmitate Phase 4
15 Clindamycin phosphate Phase 4
16 Amoxicillin-Potassium Clavulanate Combination Phase 4
17 Antibiotics, Antitubercular Phase 4
18 beta-Lactamase Inhibitors Phase 4
19 proline Nutraceutical Phase 4
20 Vaccines Phase 2,Phase 1
21
Iron Approved Phase 1 7439-89-6 23925
22
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
23
Imidazole Experimental, Investigational Phase 1 288-32-4 795
24 Monophosphoryl lipid A Phase 1
25 Adjuvants, Immunologic Phase 1
26 Gastrointestinal Agents Phase 1
27 Antacids Phase 1
28 Anti-Ulcer Agents Phase 1
29 methicillin
30 Adrenergic Agents
31 Adrenergic Antagonists
32 Adrenergic beta-Antagonists
33 Neurotransmitter Agents

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Intravenous Immunoglobulins (IVIG) in Toxic Shock Syndromes in Children Not yet recruiting NCT02899702 Phase 4 PRIVIGEN (CSL Behring);Albumin
2 De-escalation of Empirical Antimicrobial Therapy Study in Severe Sepsis Completed NCT01626612 Phase 3
3 Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot Study Unknown status NCT02219165 Phase 2 Intravenous human immunoglobulin;Albumin
4 Clinical Trial of the BioMed rTSST‐1 Variant Vaccine in Healthy Adults Recruiting NCT02814708 Phase 2
5 Phase I STEBVax in Healthy Adults Completed NCT00974935 Phase 1 Aluminum hydroxide
6 Amendment of rTSST-1 Variant Vaccine Phase 1 Clinical Trial Completed NCT02971670 Phase 1
7 rTSST-1 Variant Vaccine Phase 1 First-in-man Trail Completed NCT02340338 Phase 1
8 Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy Adults Completed NCT01717950 Phase 1
9 Role of Beta-blockers in the Prevention on the Arisen of a Severe Sepsis (TESS) Completed NCT01606631
10 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
11 Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus Completed NCT01141101
12 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
13 Pediatric Immune Response to Infectious Shock Recruiting NCT02848144 Not Applicable
14 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128
15 Cups or Cash for Girls Trial to Reduce Sexual and Reproductive Harm and School Dropout Recruiting NCT03051789 Not Applicable

Search NIH Clinical Center for Toxic Shock Syndrome

Cochrane evidence based reviews: shock, septic

Genetic Tests for Toxic Shock Syndrome

Anatomical Context for Toxic Shock Syndrome

MalaCards organs/tissues related to Toxic Shock Syndrome:

41
T Cells, Skin, Colon, Monocytes, B Cells, Endothelial, Neutrophil

Publications for Toxic Shock Syndrome

Articles related to Toxic Shock Syndrome:

(show top 50) (show all 721)
# Title Authors Year
1
Contribution of toxic shock syndrome toxin-1 to systemic inflammation investigated by a mouse model of cervicovaginal infection with Staphylococcus aureus. ( 29980843 )
2018
2
The effect of vaginal microbial communities on colonization by Staphylococcus aureus with the gene for toxic shock syndrome toxin 1 (TSST-1): a case-control study. ( 29762733 )
2018
3
Clinical and Molecular Epidemiology of Staphylococcal Toxic Shock Syndrome in the United Kingdom. ( 29350159 )
2018
4
Draft Genome Sequence of Streptococcus suis Strain SsRC-1, a Human Isolate from a Fatal Case of Toxic Shock Syndrome. ( 29773639 )
2018
5
Polyspecific intravenous immunoglobulin in clindamycin-treated patients with streptococcal toxic shock syndrome: a systematic review and meta-analysis. ( 29788397 )
2018
6
The Evaluation and Management of Toxic Shock Syndrome in the Emergency Department: A Review of the Literature. ( 29366615 )
2018
7
Periocular Necrotizing Fasciitis with Toxic Shock Syndrome. ( 29928226 )
2018
8
RS3PE syndrome developing during the course of probable toxic shock syndrome: a case report. ( 29653519 )
2018
9
Epidemiology and Clinical Relevance of Toxic Shock Syndrome in US Children. ( 29601458 )
2018
10
Molecular characterization and antibiotic resistance of Streptococcus dysgalactiae subspecies equisimilis isolated from patients with streptococcal toxic shock syndrome. ( 29107650 )
2018
11
Frequency of enterotoxins, toxic shock syndrome toxin-1, and biofilm formation genes in Staphylococcus aureus isolates from cows with mastitis in the Northeast of Brazil. ( 29429115 )
2018
12
Fulminant streptococcal toxic shock syndrome. ( 29741523 )
2018
13
Innate immune responses following Kawasaki disease and toxic shock syndrome. ( 29447181 )
2018
14
Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes. ( 29254479 )
2017
15
Complete Genome Sequence and Comparative Genomics of a Streptococcus pyogenes emm3 Strain M3-b isolated from a Japanese Patient with Streptococcal Toxic Shock Syndrome. ( 28698738 )
2017
16
Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. ( 28580155 )
2017
17
Group A Streptococcal Peritonitis and Toxic Shock Syndrome in a Postmenopausal Woman. ( 28824068 )
2017
18
Macro- and Microvascular Parameters Following Toxic Shock Syndrome. ( 29112091 )
2017
19
Toxic shock syndrome, tampons and laboratory standard-setting. ( 28536130 )
2017
20
Rare presentation of necrotising fasciitis and streptococcal toxic shock syndrome by group A streptococcus. ( 28954758 )
2017
21
Post-partum streptococcal toxic shock syndrome associated with necrotizing fasciitis. ( 28725564 )
2017
22
Toxic shock syndrome in paediatric thermal injuries: A case series and systematic literature review. ( 28867411 )
2017
23
Case of toxic shock syndrome triggered by negative-pressure wound therapy. ( 28862320 )
2017
24
Toxic Shock Syndrome: Still a Timely Diagnosis. ( 29040243 )
2017
25
Erratum: Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. ( 28721224 )
2017
26
Infective Endocarditis Associated with Streptococcal Toxic Shock Syndrome due to <i>Streptococcus dysgalactiae</i> subsp. <i>equisimilis</i> Infection in a Hemodialysis Patient. ( 29457020 )
2017
27
Vaccine against toxic shock syndrome in a first-in-man clinical trial. ( 27918218 )
2017
28
Toxic shock syndrome due to community-acquired methicillin-resistant Staphylococcus aureus infection: Two case reports and a literature review in Japan. ( 28491813 )
2017
29
HLA-DR polymorphisms influence in vivo responses to staphylococcal toxic shock syndrome toxin-1 in a transgenic mouse model. ( 27863161 )
2017
30
Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid. ( 28299216 )
2017
31
Prevalence, comorbidities and mortality of toxic shock syndrome in United States children and adults. ( 28892185 )
2017
32
Septic miscarriage with toxic shock syndrome and disseminated intravascular coagulation (DIC): The role of surgery, recombinant activated factor VII and intravenous immunoglobulin (IVIG). ( 29308782 )
2017
33
Streptococcal toxic-shock syndrome due to Streptococcus dysgalactiae subspecies equisimilis in breast cancer-related lymphedema: a case report. ( 28705211 )
2017
34
Inverse relationship between toxic shock syndrome toxin-1 antibodies and interferon-I^ and interleukin-6 in peripheral blood mononuclear cells from patients with pediatric tonsillitis caused by Staphylococcus aureus. ( 28483238 )
2017
35
A 2-year-old boy with circulatory failure owing to streptococcal toxic shock syndrome: case report. ( 28426384 )
2017
36
Toxic shock syndrome - the seven Rs of management and treatment. ( 28646955 )
2017
37
Toxic shock syndrome: A dermatological emergency. ( 28960233 )
2017
38
The Superantigen Toxic Shock Syndrome Toxin-1 Alters Human Aortic Endothelial Cell Function. ( 29229737 )
2017
39
Toxic Shock Syndrome within 24 H of an Office Hysteroscopy. ( 28706411 )
2017
40
Streptococcal toxic shock syndrome occurring in the third trimester of pregnancy: A case report. ( 28762570 )
2017
41
Group B Streptococcal Toxic Shock Syndrome and covR/S Mutations Revisited. ( 27983484 )
2017
42
Two Catastrophes in One Patient: Drug Reaction with Eosinophilia and Systemic Symptoms and Toxic Shock Syndrome. ( 28721327 )
2017
43
Use of Hemadsorption in a Case of Pediatric Toxic Shock Syndrome. ( 28791185 )
2017
44
Toxic Shock Syndrome ( 29083727 )
2017
45
Streptococcal Toxic Shock Syndrome Caused by Group G Streptococcus, United Kingdom. ( 27983491 )
2017
46
Toxic shock syndrome caused by suture abscess with methicillin-resistant Staphylococcus aureus (MRSA) with late onset after Caesarean section. ( 28791216 )
2017
47
Pleural empyema and streptococcal toxic shock syndrome due to Streptococcus pyogenes in a healthy Spanish traveler in Japan. ( 28725562 )
2017
48
The Management of Staphylococcal Toxic Shock Syndrome. A Case Report. ( 29967843 )
2016
49
Relevance of spontaneous fabT mutations to a streptococcal toxic shock syndrome to non-streptococcal toxic shock syndrome transition in the novel-type Streptococcus pyogenes isolates that lost a salRK. ( 26861052 )
2016
50
Veno-arterial extracorporeal membrane oxygenation for Streptococcus pyogenes toxic shock syndrome in pregnancy. ( 26758056 )
2016

Variations for Toxic Shock Syndrome

ClinVar genetic disease variations for Toxic Shock Syndrome:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TNF TNF, -308G-A single nucleotide variant risk factor

Expression for Toxic Shock Syndrome

Search GEO for disease gene expression data for Toxic Shock Syndrome.

Pathways for Toxic Shock Syndrome

Pathways related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.11 C1S CIITA CXCL8 HMGB1 IFNG IL10
2
Show member pathways
13.76 CXCL8 IFNG IL10 IL1B IL2 IL4
3
Show member pathways
13.61 CXCL8 IFNG IL10 IL1B IL2 IL4
4
Show member pathways
13.53 CXCL8 IL10 IL1B IL2 IL4 IL6
5
Show member pathways
13.48 CIITA CXCL8 IFNG IL10 IL1B IL2
6
Show member pathways
13.39 CXCL8 IL10 IL1B IL2 IL4 IL6
7
Show member pathways
13.13 CXCL8 IFNG IL10 IL1B IL2 IL6
8
Show member pathways
13.05 IL2 IL4 IL6 TLR2 TLR4 TNF
9
Show member pathways
13.01 CIITA CXCL8 IFNG IL10 IL1B IL2
10
Show member pathways
12.95 HMGB1 IFNG IL1B IL2 IL4 TLR2
11
Show member pathways
12.93 IL2 IL4 IL6 LTA TNF
12
Show member pathways
12.9 CXCL8 HMGB1 IFNG IL1B IL6 TLR4
13 12.88 CXCL8 IFNG IL2 IL4 IL6
14
Show member pathways
12.85 IL1B IL2 IL6 LTA TLR2 TLR4
15
Show member pathways
12.74 CXCL8 IFNG IL10 IL1B IL2 IL4
16
Show member pathways
12.72 IFNG IL10 IL1B IL2 IL6 TNF
17 12.72 CIITA IFNG IL10 IL1B IL2 IL4
18
Show member pathways
12.69 CIITA CXCL8 IFNG IL1B IL2 IL4
19
Show member pathways
12.66 CXCL8 IL6 TLR2 TLR4 TNF
20
Show member pathways
12.64 IL1B LTA TLR2 TLR4 TNF
21
Show member pathways
12.61 IFNG IL10 IL1B IL2 IL4 IL6
22
Show member pathways
12.54 IFNG IL2 IL4 TNF
23
Show member pathways
12.51 CXCL8 IFNG IL1B IL4 IL6 TLR2
24
Show member pathways
12.49 IFNG IL1B IL2 IL4 IL6 TNF
25
Show member pathways
12.48 IFNG IL10 IL1B IL2 IL4 IL6
26 12.47 IL2 IL6 LTA TNF
27
Show member pathways
12.44 CXCL8 IFNG IL1B IL6 TLR4 TNF
28
Show member pathways
12.41 CIITA IFNG IL10 IL1B IL4 TLR2
29
Show member pathways
12.4 CXCL8 IL6 TLR2 TLR4 TNF
30 12.38 CIITA IFNG IL10 IL1B IL6 TLR2
31
Show member pathways
12.36 CXCL8 IL1B IL6 TLR2 TNF
32
Show member pathways
12.35 IL10 IL1B IL2 IL6 TNF
33
Show member pathways
12.35 HMGB1 IFNG IL1B TLR4 TNF
34 12.32 IFNG IL6 TLR2 TLR4 TNF
35 12.32 CXCL8 IL10 IL1B IL6 TNF
36
Show member pathways
12.3 CXCL8 IFNG IL1B IL4 IL6 TLR2
37
Show member pathways
12.25 IFNG IL10 IL1B IL2 IL6 LTA
38
Show member pathways
12.24 CXCL8 IFNG IL10 IL1B IL2 IL4
39 12.19 IFNG IL10 IL2 IL4 IL6 TNF
40 12.18 CXCL8 IL10 IL1B IL4 IL6 TNF
41
Show member pathways
12.13 IL1B IL2 TLR2 TLR4
42
Show member pathways
12.09 IFNG IL1B IL2 IL4
43 12.07 IL1B IL6 LTA TNF
44 12.06 CXCL8 IFNG IL1B IL6
45 12.06 CXCL8 IL1B LTA TLR4 TNF
46 12.05 CXCL8 IFNG IL1B IL2 IL4 IL6
47 12.03 CXCL8 IL1B IL6 TNF
48 12.02 IL1B IL4 IL6 TNF
49 12.01 CXCL8 IFNG IL1B IL6 TLR4
50 12.01 CXCL8 IFNG IL1B IL6 TLR2 TLR4

GO Terms for Toxic Shock Syndrome

Cellular components related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 C1S CXCL8 HMGB1 IFNG IL10 IL1B
2 cell surface GO:0009986 9.55 CIITA HMGB1 TLR2 TLR4 TNF
3 extracellular space GO:0005615 9.4 C1S CXCL8 HMGB1 IFNG IL10 IL1B

Biological processes related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.99 HMGB1 IFNG IL1B IL2 TNF
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.98 IL1B IL6 TLR2 TLR4 TNF
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.97 IL10 IL1B IL6 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.97 CXCL8 IL10 IL6 TLR4 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.95 IL6 LTA TLR2 TNF
6 positive regulation of JNK cascade GO:0046330 9.93 HMGB1 IL1B TLR4 TNF
7 response to glucocorticoid GO:0051384 9.92 HMGB1 IL10 IL6 TNF
8 positive regulation of T cell proliferation GO:0042102 9.91 IL1B IL2 IL4 IL6
9 inflammatory response GO:0006954 9.91 CIITA CXCL8 HMGB1 IL10 IL1B IL6
10 positive regulation of inflammatory response GO:0050729 9.9 IL2 TLR2 TLR4
11 regulation of insulin secretion GO:0050796 9.89 IFNG IL1B TNF
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 IFNG IL2 IL6
13 positive regulation of tumor necrosis factor production GO:0032760 9.87 HMGB1 TLR2 TLR4
14 toll-like receptor signaling pathway GO:0002224 9.87 HMGB1 TLR2 TLR4
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.87 IFNG IL1B TLR4 TNF
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.86 IL1B TLR2 TLR4 TNF
17 positive regulation of B cell proliferation GO:0030890 9.85 IL2 IL4 TLR4
18 positive regulation of interleukin-8 production GO:0032757 9.85 IL1B TLR2 TLR4 TNF
19 humoral immune response GO:0006959 9.85 IFNG IL6 LTA TNF TREM1
20 negative regulation of interleukin-6 production GO:0032715 9.83 IL10 TLR4 TNF
21 negative regulation of interferon-gamma production GO:0032689 9.83 HMGB1 IL10 TLR4
22 positive regulation of interferon-beta production GO:0032728 9.83 HMGB1 TLR2 TLR4
23 positive regulation of interleukin-12 production GO:0032735 9.83 HMGB1 IFNG TLR2 TLR4
24 positive regulation of interleukin-10 production GO:0032733 9.82 HMGB1 TLR2 TLR4
25 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.81 IFNG IL1B TNF
26 negative regulation of growth of symbiont in host GO:0044130 9.8 IL10 LTA TNF
27 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 HMGB1 IL1B TLR2 TLR4 TNF
28 response to molecule of bacterial origin GO:0002237 9.79 CXCL8 IL10 TLR2
29 positive regulation of chemokine production GO:0032722 9.78 IL6 TLR2 TLR4 TNF
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.77 IL10 IL1B TNF
31 positive regulation of interferon-gamma production GO:0032729 9.77 IL1B IL2 LTA TLR4 TNF
32 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.74 TLR2 TLR4
33 negative regulation of collagen biosynthetic process GO:0032966 9.74 CIITA IL6
34 inflammatory response to antigenic stimulus GO:0002437 9.74 HMGB1 IL1B
35 positive regulation of interferon-alpha production GO:0032727 9.74 HMGB1 TLR4
36 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.74 HMGB1 IL1B
37 positive regulation of immunoglobulin secretion GO:0051024 9.73 IL2 IL6
38 I-kappaB phosphorylation GO:0007252 9.73 TLR2 TLR4
39 regulation of cytokine secretion GO:0050707 9.73 TLR2 TLR4
40 cellular response to lipoteichoic acid GO:0071223 9.73 TLR2 TLR4
41 negative regulation of interleukin-17 production GO:0032700 9.73 IFNG TLR4
42 negative regulation of lipid storage GO:0010888 9.72 IL6 TNF
43 positive regulation of isotype switching to IgG isotypes GO:0048304 9.72 IL2 IL4
44 positive regulation of chemokine biosynthetic process GO:0045080 9.71 IL1B TNF
45 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.71 TLR4 TNF
46 endothelial cell apoptotic process GO:0072577 9.71 IL10 TNF
47 regulation of establishment of endothelial barrier GO:1903140 9.71 IL1B TNF
48 negative regulation of cytokine secretion involved in immune response GO:0002740 9.7 IL10 TNF
49 type 2 immune response GO:0042092 9.7 IL10 IL4
50 positive regulation of fever generation GO:0031622 9.7 IL1B TNF

Molecular functions related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 IL10 IL2 IL4 IL6
2 cytokine activity GO:0005125 9.32 CXCL8 HMGB1 IFNG IL10 IL1B IL2
3 lipopolysaccharide receptor activity GO:0001875 9.26 TLR2 TLR4
4 lipopolysaccharide binding GO:0001530 9.13 HMGB1 TLR2 TLR4
5 protein binding GO:0005515 10.22 C1S CIITA CXCL8 HMGB1 IFNG IL10

Sources for Toxic Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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