MCID: TXC021
MIFTS: 12

Toxicity or Absent Response to Clozapine

Categories: Rare diseases

Aliases & Classifications for Toxicity or Absent Response to Clozapine

MalaCards integrated aliases for Toxicity or Absent Response to Clozapine:

Name: Toxicity or Absent Response to Clozapine 60

Classifications:



External Ids:

Orphanet 60 ORPHA284121

Summaries for Toxicity or Absent Response to Clozapine

MalaCards based summary : Toxicity or Absent Response to Clozapine is related to tardive dyskinesia and anxiety. Among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Paroxetine Pathway, Pharmacokinetics. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Toxicity or Absent Response to Clozapine

Diseases related to Toxicity or Absent Response to Clozapine via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 tardive dyskinesia 9.7 COMT CYP1A2
2 anxiety 9.6 COMT CYP1A2
3 schizophrenia 9.5 COMT CYP1A2

Symptoms & Phenotypes for Toxicity or Absent Response to Clozapine

GenomeRNAi Phenotypes related to Toxicity or Absent Response to Clozapine according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.36 CYP1A2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.36 CYP1A2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.36 CYP1A2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.36 COMT CYP1A2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.36 COMT
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.36 CYP1A2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.36 COMT
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.36 COMT
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.36 COMT
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.36 COMT

Drugs & Therapeutics for Toxicity or Absent Response to Clozapine

Search Clinical Trials , NIH Clinical Center for Toxicity or Absent Response to Clozapine

Genetic Tests for Toxicity or Absent Response to Clozapine

Anatomical Context for Toxicity or Absent Response to Clozapine

Publications for Toxicity or Absent Response to Clozapine

Variations for Toxicity or Absent Response to Clozapine

Expression for Toxicity or Absent Response to Clozapine

Search GEO for disease gene expression data for Toxicity or Absent Response to Clozapine.

Pathways for Toxicity or Absent Response to Clozapine

Pathways related to Toxicity or Absent Response to Clozapine according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 COMT CYP1A2
2
Show member pathways
11.45 COMT CYP1A2
3
Show member pathways
11.08 COMT CYP1A2
4
Show member pathways
10.96 COMT CYP1A2
5
Show member pathways
10.69 COMT CYP1A2
6
Show member pathways
10.15 COMT CYP1A2

GO Terms for Toxicity or Absent Response to Clozapine

Cellular components related to Toxicity or Absent Response to Clozapine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 8.62 COMT CYP1A2

Biological processes related to Toxicity or Absent Response to Clozapine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.26 COMT CYP1A2
2 methylation GO:0032259 9.16 COMT CYP1A2
3 response to lipopolysaccharide GO:0032496 8.96 COMT CYP1A2
4 response to organic cyclic compound GO:0014070 8.62 COMT CYP1A2

Sources for Toxicity or Absent Response to Clozapine

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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