MCID: TXC021
MIFTS: 12

Toxicity or Absent Response to Clozapine

Categories: Rare diseases

Aliases & Classifications for Toxicity or Absent Response to Clozapine

MalaCards integrated aliases for Toxicity or Absent Response to Clozapine:

Name: Toxicity or Absent Response to Clozapine 59

Classifications:



External Ids:

Orphanet 59 ORPHA284121

Summaries for Toxicity or Absent Response to Clozapine

Related Diseases for Toxicity or Absent Response to Clozapine

Diseases related to Toxicity or Absent Response to Clozapine via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 tardive dyskinesia 9.2 COMT CYP1A2
2 schizophrenia 9.0 COMT CYP1A2

Symptoms & Phenotypes for Toxicity or Absent Response to Clozapine

GenomeRNAi Phenotypes related to Toxicity or Absent Response to Clozapine according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.36 CYP1A2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.36 CYP1A2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.36 CYP1A2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.36 COMT CYP1A2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.36 COMT
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.36 CYP1A2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.36 COMT
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.36 COMT
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.36 COMT
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.36 COMT

Drugs & Therapeutics for Toxicity or Absent Response to Clozapine

Search Clinical Trials , NIH Clinical Center for Toxicity or Absent Response to Clozapine

Genetic Tests for Toxicity or Absent Response to Clozapine

Anatomical Context for Toxicity or Absent Response to Clozapine

Publications for Toxicity or Absent Response to Clozapine

Variations for Toxicity or Absent Response to Clozapine

Expression for Toxicity or Absent Response to Clozapine

Search GEO for disease gene expression data for Toxicity or Absent Response to Clozapine.

Pathways for Toxicity or Absent Response to Clozapine

Pathways related to Toxicity or Absent Response to Clozapine according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 COMT CYP1A2
2
Show member pathways
11.22 COMT CYP1A2
3
Show member pathways
11.07 COMT CYP1A2
4
Show member pathways
10.9 COMT CYP1A2
5
Show member pathways
10.69 COMT CYP1A2
6
Show member pathways
10.15 COMT CYP1A2

GO Terms for Toxicity or Absent Response to Clozapine

Cellular components related to Toxicity or Absent Response to Clozapine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 8.62 COMT CYP1A2

Biological processes related to Toxicity or Absent Response to Clozapine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.26 COMT CYP1A2
2 methylation GO:0032259 9.16 COMT CYP1A2
3 response to lipopolysaccharide GO:0032496 8.96 COMT CYP1A2
4 response to organic cyclic compound GO:0014070 8.62 COMT CYP1A2

Sources for Toxicity or Absent Response to Clozapine

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....