MCID: TXC011
MIFTS: 46

Toxocariasis

Categories: Cardiovascular diseases, Gastrointestinal diseases, Infectious diseases, Muscle diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Toxocariasis

MalaCards integrated aliases for Toxocariasis:

Name: Toxocariasis 12 73 20 58 54 3 15 17 70
Larva Migrans, Visceral 44 70
Visceral Larva Migrans 12 32
Toxocara Infection 12 3
Infection by Toxascaris 12
Larva Migrans Visceral 54

Characteristics:

Orphanet epidemiological data:

58
toxocariasis
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9790
MeSH 44 D007816
NCIt 50 C34758
SNOMED-CT 67 87121004
ICD10 32 B83.0
MESH via Orphanet 45 D014120
ICD10 via Orphanet 33 B83.0
UMLS via Orphanet 71 C0040553
Orphanet 58 ORPHA3343
UMLS 70 C0023049 C0040553

Summaries for Toxocariasis

GARD : 20 Toxocariasis is a parasitic condition caused by the larvae of two species of Toxocara roundworms: Toxocara canis (from dogs) and Toxocara cati (from cats). Many people who are infected with Toxocara never develop any signs or symptoms of the condition. In those who do become sick, symptoms may present as: Ocular Toxocariasis - when the larvae infect the eye and cause vision loss, eye inflammation, and/or damage to the retina. Visceral Toxocariasis - when the larvae infect various organs of the body (i.e. the liver or the central nervous system ) and cause fever, fatigue, coughing, wheezing, and/or abdominal pain. Toxocariasis is generally spread through dirt that has been contaminated with animal feces that contain infectious Toxocara eggs. Young children and owners of dogs and cats have a higher chance of becoming infected. Visceral toxocariasis is treated with antiparasitic medications. Treatment of ocular toxocariasis is more difficult and usually consists of measures to prevent progressive damage to the eye.

MalaCards based summary : Toxocariasis, also known as larva migrans, visceral, is related to toxoplasmosis and echinococcosis. An important gene associated with Toxocariasis is IGHE (Immunoglobulin Heavy Constant Epsilon), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Albendazole and Tubulin Modulators have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves zoonotic infection of humans by the larvae of Toxocara canis or Toxocara cati. The larvae invade multiple tissues like liver, heart, lungs, brain, muscle and eyes causing various symptoms including fever, anorexia, weight loss, cough, wheezing, rashes, hepatosplenomegaly, hypereosinophilia and ophthalmologic lesions.

CDC : 3 Toxocariasis is the parasitic disease caused by the larvae of two species of Toxocara roundworms: Toxocara canis from dogs and, less commonly, Toxocara cati from cats. Toxocariasis is considered one of the Neglected Parasitic Infections, a group of five parasitic diseases that have been targeted by CDC for public health action.

Wikipedia : 73 Toxocariasis is an illness of humans caused by larvae (immature worms) of either the dog roundworm... more...

Related Diseases for Toxocariasis

Diseases related to Toxocariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 442)
# Related Disease Score Top Affiliating Genes
1 toxoplasmosis 30.6 IL5 IL4 IL10
2 echinococcosis 30.6 RNASE3 IL5 IL10
3 hypereosinophilic syndrome 30.6 RNASE3 IL5 IL4 IL13 IGHE FIP1L1
4 posterior uveitis 30.2 IL5 IL4 IL13
5 chorioretinitis 30.2 IL10 CRP
6 anisakiasis 30.2 TES RNASE3 IGHE
7 cytokine deficiency 30.1 IL5 IL13
8 sparganosis 30.1 TES CTSL
9 eosinophilic gastroenteritis 30.0 RNASE3 IL5 IL4
10 enterobiasis 30.0 TES IL4
11 cysticercosis 30.0 IL5 IL4 IL10 IGHE CTSL
12 contact dermatitis 29.9 IL5 IL4 IL10
13 eosinophilic pneumonia 29.9 RNASE3 IL5 IL4 IL13
14 idiopathic nephrotic syndrome 29.9 IL4 IGHE
15 volvulus of midgut 29.9 IL5 CRP
16 erythema nodosum 29.9 IL13 IL10 CRP
17 pemphigoid 29.8 IL5 IL4 IL13
18 clonorchiasis 29.8 IL10 IGHE CTSL
19 wells syndrome 29.8 RNASE3 IL5 CRP
20 cellulitis 29.8 RNASE3 IL5 CRP
21 filariasis 29.8 IL5 IL10 IGHE CRP
22 iridocyclitis 29.8 IL10 CRP
23 angioedema 29.8 IL5 IGHE CRP
24 strongyloidiasis 29.7 TES IL5 IL4 IL13 IGHE
25 aspergillosis 29.7 IL5 IL4 IL10
26 common cold 29.7 RNASE3 IL5 IL4 IL13 IL10
27 trichinosis 29.6 IL5 IL4 IL13 IL10
28 cough variant asthma 29.6 RNASE3 IL5 IL4 IGHE
29 rubella 29.6 IL5 IL4 IL10
30 eosinophilic meningitis 29.6 IL5 IL4 IL13 IL10 IGHE
31 purpura 29.6 IL4 IL10 CRP
32 peritonitis 29.6 IL4 IL10 CRP
33 radiculopathy 29.5 IL5 IL13 IL10
34 schistosomiasis 29.5 RNASE3 IL5 IL4 IL13 IL10 IGHE
35 leishmaniasis 29.5 IL5 IL4 IL13 IL10
36 scleritis 29.5 IL5 IL4 CRP
37 chronic urticaria 29.5 RNASE3 IL4 IL13 IGHE CRP
38 bullous pemphigoid 29.4 RNASE3 IL5 IL4 IL13 IGHE
39 rhinitis 29.4 RNASE3 IL5 IL4 IL13 IL10 IGHE
40 chronic rhinitis 29.4 RNASE3 IL5 IL4 IL13
41 chickenpox 29.4 IL4 IL10 CRP
42 esophagitis, eosinophilic, 1 29.4 RNASE3 IL5 IL4 IL13
43 pulmonary eosinophilia 29.4 RNASE3 IL5 IL4 IL13
44 interstitial lung disease 29.4 IL5 IL4 IL13 IL10 CRP
45 irritable bowel syndrome 29.4 IL4 IL10 CRP
46 gastroenteritis 29.3 RNASE3 IL5 IL4 IL10 CRP
47 allergic disease 29.3 RNASE3 IL5 IL4 IL13 IL10 IGHE
48 viral hepatitis 29.3 IL4 IL10 CRP
49 filarial elephantiasis 29.3 IL5 IL4 IL13 IL10
50 parasitic helminthiasis infectious disease 29.3 TES RNASE3 IL5 IL4 IL13 IL10

Comorbidity relations with Toxocariasis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease

Graphical network of the top 20 diseases related to Toxocariasis:



Diseases related to Toxocariasis

Symptoms & Phenotypes for Toxocariasis

Drugs & Therapeutics for Toxocariasis

Drugs for Toxocariasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
2 Tubulin Modulators Phase 3
3 Antiparasitic Agents Phase 3
4 Antimitotic Agents Phase 3
5 Anthelmintics Phase 3
6 Antiprotozoal Agents Phase 3
7 Anti-Infective Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Asymptomatic Toxocariasis With Albendazole in Children. A Prospective, Randomized, Placebo-controlled Clinical Trial Unknown status NCT00755560 Phase 3 Albendazole;Placebo
2 A Study for the Ocular Toxocariasis in the Patients Who Were Diagnosed With the Pulmonary Toxocariasis, and Ocular Toxocariasis Cohort: TOXOCARA Study Unknown status NCT03814837

Search NIH Clinical Center for Toxocariasis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Albendazole

Cochrane evidence based reviews: larva migrans, visceral

Genetic Tests for Toxocariasis

Anatomical Context for Toxocariasis

MalaCards organs/tissues related to Toxocariasis:

40
Eye, Retina, Brain, Spinal Cord, Bone Marrow, Colon, Spleen

Publications for Toxocariasis

Articles related to Toxocariasis:

(show top 50) (show all 1777)
# Title Authors PMID Year
1
Toxocariasis mimicking liver, lung, and spinal cord metastases from retinoblastoma. 54 61
19209093 2009
2
[Estimation of eosinophilia, immunoglobulin E and eosinophilic cationic protein concentration during the treatment of toxocariasis]. 54 61
19055065 2008
3
[A case of hepatic abscess caused by toxocara]. 61 54
17898557 2007
4
Eosinophil cationic protein, specific IgE and IgG4 in human toxocariasis. 61 54
17125552 2006
5
Eosinophil cationic protein as a possible marker of active human Toxocara infection. 54 61
11703226 2001
6
Human toxocariasis and pyogenic liver abscess: a possible association. 54 61
11232707 2001
7
Relationship between allergic manifestations and Toxocara seropositivity: a cross-sectional study among elementary school children. 61 54
9230232 1997
8
Experimental congenital toxocariasis: effect on foetal future immune response. 61 54
8918035 1996
9
Cerebral Toxocariasis as a Cause of Epilepsy: A Pediatric Case. 61
33472248 2021
10
A Rare Case of Congenitally Acquired Ocular Toxocariasis in A Five-Week-Old Infant. 61
33661077 2021
11
A new ELISA and western blot technique based on recombinant TES antigen and/or larval antigen for the detection of toxocariasis in humans. 61
33092663 2021
12
Detection of larvae of Toxocara cati and T. tanuki from the muscles of free-ranging layer farm chickens. 61
33740118 2021
13
Saccharomyces boulardii reduces the vertical transmission of Toxocara canis larvae in mice. 61
33650475 2021
14
Development of a low-cost copro-LAMP assay for simultaneous copro-detection of Toxocara canis and Toxocara cati. 61
33593468 2021
15
A prospective seroepidemiological study of toxocariasis during early childhood in coastal Ecuador: potential for congenital transmission and risk factors for infection. 61
33546758 2021
16
Unnoticed metallic foreign body in the camerular angle inducing chronic uveitis. 61
33567027 2021
17
The first two cases of neurotoxocariasis in Taiwan. 61
33593692 2021
18
Proteomic alterations in the plasma of Beagle dogs induced by Toxocara canis infection. 61
33212252 2021
19
The global prevalence of Toxocara spp. in pediatrics: a systematic review and meta-analysis. 61
33561339 2021
20
Hepatic Visceral Larva Migrans Causing Hepatic Artery Pseudo-Aneurysm. 61
33632956 2021
21
Toxocariasis in a Child with Autism Spectrum Disorder. 61
33401653 2021
22
The association between seropositivity to human toxocariasis and childhood asthma in northern Iran: a case-control study. 61
33528926 2021
23
Multimodality Image Analysis in a Cohort of Patients with Atypical Juvenile Ocular Toxocariasis. 61
33628474 2021
24
Ocular Toxocariasis in Parasitology Consultation in Quindío, Colombia: Description of Cases and Contact Studies. 61
33313750 2021
25
Identification and Immunological Characterization of Somatic Proteins from Adults of Toxocara cati by Proteomics Technique. 61
33786044 2021
26
Protective effect of the probiotic Lactobacillus acidophilus ATCC 4356 in BALB/c mice infected with Toxocara canis. 61
33533812 2021
27
Global profiling of lncRNAs-miRNAs-mRNAs reveals differential expression of coding genes and non-coding RNAs in the lung of beagle dogs at different stages of Toxocara canis infection. 61
32991917 2021
28
Proteomic analysis of soluble protein extract of adult Toxocara cati. 61
32911377 2020
29
Human toxocariasis, a silent helminthic disease revealed in Savannakhet, Lao PDR. 61
33392380 2020
30
Evidence for Asthma in the Lungs of Mice Inoculated with Different Doses of Toxocara canis. 61
32975177 2020
31
Clinical features of ocular toxocariasis: a comparison between ultra-wide-field and conventional camera imaging. 61
33273717 2020
32
Parasitic helminth infections of dogs, wolves, foxes, and golden jackals in Mazandaran Province, North of Iran. 61
33487982 2020
33
Toxocariasis Presenting with Hypereosinophilia and Lymphadenopathy: A Case Report. 61
33269576 2020
34
Clinical Features and Prognostic Factors in Northern Chinese Patients with Peripheral Granuloma Type of Ocular Toxocariasis: A Retrospective Cohort Study. 61
33185484 2020
35
AcanR3990 qPCR: a novel, highly sensitive, bioinformatically-informed assay to detect Angiostrongylus cantonensis infections. 61
33252651 2020
36
Humoral immune response of pigs infected with Toxocara cati. 61
32946882 2020
37
Pulmonary Exacerbation of Undiagnosed Toxocariasis in Intensively-Treated High-Risk Neuroblastoma Patients. 61
33028049 2020
38
Status of human toxocariasis, a neglected parasitic zoonosis in Iran: a systematic review from past to current. 61
32998656 2020
39
[Bilateral ocular toxocariasis: Case report from Madagascar]. 61
32653098 2020
40
Efficacy of a chlorocresol-based disinfectant product on Toxocara canis eggs. 61
32556502 2020
41
Quantification of Toxocara canis DNA by qPCR in mice inoculated with different infective doses. 61
32416257 2020
42
Visceral larva migrans due to Toxocara in elderly patient. 61
32146047 2020
43
Seropositivity and risk factors of Toxocara canis infection in adult asthmatic patients. 61
33612775 2020
44
A Systematic Review and Meta-analysis of Toxocariasis in Iran: Is it Time to Take it Seriously? 61
32319035 2020
45
Study of toxoplasmosis and toxocariasis in patients suffering from ophthalmic disorders using serological and molecular methods. 61
32424529 2020
46
Distribution of Toxocara cati larvae in experimentally infected BALB/c mice. 61
32950910 2020
47
Long-Term Clinical Results and Management following Vitrectomy in Undetected Retinoblastoma Eyes. 61
33005613 2020
48
Pediatric Ocular Toxocariasis in Costa Rica: 1998-2018 Experience. 61
32809906 2020
49
Ocular Toxocariasis: Beyond Typical Patterns through the New Imaging Technologies. 61
32835578 2020
50
Prevalence of Toxocariasis and Its Risk Factors in Patients with Eosinophilia in Korea. 61
32871635 2020

Variations for Toxocariasis

Expression for Toxocariasis

Search GEO for disease gene expression data for Toxocariasis.

Pathways for Toxocariasis

Pathways related to Toxocariasis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 SLC44A2 RNASE3 IL5 IL4 IL13 IL10
2
Show member pathways
12.62 RNASE3 IL5 IL4 IL13 IL10 CTSL
3
Show member pathways
12.41 IL5 IL4 IL13 IL10
4
Show member pathways
12.38 IL5 IL4 IL13 IGHE
5
Show member pathways
12.22 IL5 IL4 IL13 IL10
6
Show member pathways
12.07 IL5 IL4 IL13 IL10
7 11.82 IL5 IL4 IL10
8 11.79 IL4 IL13 IL10 IGHE
9 11.63 IL5 IL4 IL13
10 11.57 IL5 IL4 IL13 IL10
11 11.51 IL5 IL4 IL10
12 11.47 IL5 IL4 IL13
13 11.36 IL5 IL4 IL10 IGHE
14 11.34 IL4 IL13 IL10
15 11.14 IL5 IL4 IL13
16 11.12 IL5 IL4 IL13 IL10
17 10.72 IL5 IL4 IL13 IL10
18 10.58 IL5 IL4 IL13
19 10.34 IL5 IL4 IL13 IL10

GO Terms for Toxocariasis

Cellular components related to Toxocariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 TCN2 RNASE3 IL5 IL4 IL13 IL10
2 extracellular region GO:0005576 9.28 TCN2 RNASE3 IL5 IL4 IL13 IL10

Biological processes related to Toxocariasis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 9.7 IL4 IL13 IL10
2 positive regulation of B cell proliferation GO:0030890 9.58 IL5 IL4 IL13
3 cytokine-mediated signaling pathway GO:0019221 9.55 IL5 IL4 IL13 IL10 IGHE
4 positive regulation of macrophage activation GO:0043032 9.54 IL13 IL10
5 macrophage activation GO:0042116 9.51 IL4 IL13
6 positive regulation of MHC class II biosynthetic process GO:0045348 9.49 IL4 IL10
7 positive regulation of mast cell degranulation GO:0043306 9.48 IL4 IL13
8 choline transport GO:0015871 9.46 SLC44A2 SLC44A1
9 type 2 immune response GO:0042092 9.43 IL4 IL10
10 negative regulation of endothelial cell apoptotic process GO:2000352 9.43 IL4 IL13 IL10
11 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL4 IL13
12 regulation of isotype switching GO:0045191 9.32 IL4 IL10
13 positive regulation of immunoglobulin production GO:0002639 9.13 IL5 IL13 IL10
14 immune response GO:0006955 9.1 IL5 IL4 IL13 IL10 IGHE CTSL

Molecular functions related to Toxocariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 IL5 IL4 IL13 IL10
2 choline transmembrane transporter activity GO:0015220 8.62 SLC44A2 SLC44A1

Sources for Toxocariasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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