MCID: TXC011
MIFTS: 42

Toxocariasis

Categories: Cardiovascular diseases, Endocrine diseases, Eye diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases, Muscle diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Toxocariasis

MalaCards integrated aliases for Toxocariasis:

Name: Toxocariasis 12 77 54 60 56 45 15 17 74 3
Larva Migrans, Visceral 45 74
Infection by Toxascaris 12
Visceral Larva Migrans 12
Larva Migrans Visceral 56
Toxocara Infection 12

Characteristics:

Orphanet epidemiological data:

60
toxocariasis
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9790
NCIt 51 C34758
SNOMED-CT 69 87121004
ICD10 34 B83.0
MESH via Orphanet 46 D014120
ICD10 via Orphanet 35 B83.0
UMLS via Orphanet 75 C0040553
Orphanet 60 ORPHA3343

Summaries for Toxocariasis

NIH Rare Diseases : 54 Toxocariasis is a parasitic condition caused by the larvae of two species of Toxocara roundworms: Toxocara canis (from dogs) and Toxocara cati (from cats). Many people who are infected with Toxocara never develop any signs or symptoms of the condition. In those who do become sick, symptoms may present as: Ocular Toxocariasis - when the larvae infect the eye and cause vision loss, eye inflammation, and/or damage to the retina. Visceral Toxocariasis - when the larvae infect various organs of the body (i.e. the liver or the central nervous system) and cause fever, fatigue, coughing, wheezing, and/or abdominal pain. Toxocariasis is generally spread through dirt that has been contaminated with animal feces that contain infectious Toxocara eggs. Young children and owners of dogs and cats have a higher chance of becoming infected. Visceral toxocariasis is treated with antiparasitic medications. Treatment of ocular toxocariasis is more difficult and usually consists of measures to prevent progressive damage to the eye. 

MalaCards based summary : Toxocariasis, also known as larva migrans, visceral, is related to schistosomiasis and urticaria. An important gene associated with Toxocariasis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways is Synthesis of PC. The drugs Albendazole and Anthelmintics have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and retina.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves zoonotic infection of humans by the larvae of Toxocara canis or Toxocara cati. The larvae invade multiple tissues like liver, heart, lungs, brain, muscle and eyes causing various symptoms including fever, anorexia, weight loss, cough, wheezing, rashes, hepatosplenomegaly, hypereosinophilia and ophthalmologic lesions.

CDC : 3 Toxocariasis is the parasitic disease caused by the larvae of two species of Toxocara roundworms: Toxocara canis from dogs and, less commonly, Toxocara cati from cats. Toxocariasis is considered one of the Neglected Parasitic Infections, a group of five parasitic diseases that have been targeted by CDC for public health action.

Wikipedia : 77 Toxocariasis is an illness of humans caused by larvae (immature worms) of either the dog roundworm... more...

Related Diseases for Toxocariasis

Diseases related to Toxocariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 schistosomiasis 30.4 IGHE RNASE3
2 urticaria 30.3 IGHE RNASE3
3 hypereosinophilic syndrome 30.0 IGHE RNASE3
4 allergic asthma 29.8 IGHE RNASE3
5 baylisascariasis 11.4
6 gnathomiasis 11.4
7 retinal vasculitis 11.4
8 baylisascaris infection 11.4
9 cysticercosis 10.3
10 atopic keratoconjunctivitis 10.2 IGHE RNASE3
11 latex allergy 10.2 IGHE RNASE3
12 vernal conjunctivitis 10.2 IGHE RNASE3
13 respiratory allergy 10.2 IGHE RNASE3
14 toxoplasmosis 10.2
15 ige responsiveness, atopic 10.2 IGHE RNASE3
16 bronchiolitis 10.2 IGHE RNASE3
17 epilepsy 10.2
18 otitis media 10.2 IGHE RNASE3
19 proteasome-associated autoinflammatory syndrome 1 10.1 IGHE RNASE3
20 conjunctival disease 10.1 MRAP RNASE3
21 thrombophilia due to thrombin defect 10.1
22 alcohol-related neurodevelopmental disorder 10.1
23 thrombosis 10.1
24 viral meningitis 10.1
25 meningoencephalitis 10.1
26 japanese encephalitis 10.1
27 hemiplegia 10.1
28 capillariasis 10.1
29 rheumatic disease 10.1
30 cholecystitis 10.1
31 gastroenteritis 10.1
32 eosinophilic gastroenteritis 10.1
33 pulmonary eosinophilia 10.1
34 chronic eosinophilic pneumonia 10.1
35 encephalitis 10.1
36 eosinophilic enteropathy 10.1
37 encephalopathy 10.1
38 uveitis 10.1
39 asthma 10.1
40 neuroretinitis 10.1
41 strongyloidiasis 10.1
42 allergic hypersensitivity disease 10.1 IGHE RNASE3
43 parasitic protozoa infectious disease 10.0 FARSA TCN2
44 rhinitis 10.0 IGHE RNASE3
45 poliomyelitis 10.0
46 filariasis 10.0
47 dermatitis, atopic 10.0 IGHE RNASE3
48 choline deficiency disease 9.9 SLC44A1 SLC44A2
49 retinoblastoma 9.9
50 arthritis 9.9

Comorbidity relations with Toxocariasis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease

Graphical network of the top 20 diseases related to Toxocariasis:



Diseases related to Toxocariasis

Symptoms & Phenotypes for Toxocariasis

Drugs & Therapeutics for Toxocariasis

Drugs for Toxocariasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
2 Anthelmintics Phase 3
3 Anti-Infective Agents Phase 3
4 Antiparasitic Agents Phase 3
5 Antimitotic Agents Phase 3
6 Antiprotozoal Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Asymptomatic Toxocariasis With Albendazole in Children Unknown status NCT00755560 Phase 3 Albendazole;Placebo
2 A Study for the Ocular Toxocariasis Patients With the Pulmonary Toxocariasis, and Ocular Toxocariasis Cohort Recruiting NCT03814837

Search NIH Clinical Center for Toxocariasis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: toxocariasis

Genetic Tests for Toxocariasis

Anatomical Context for Toxocariasis

MalaCards organs/tissues related to Toxocariasis:

42
Eye, Brain, Retina, Testes, Skin, Spinal Cord, Bone Marrow

Publications for Toxocariasis

Articles related to Toxocariasis:

(show top 50) (show all 589)
# Title Authors Year
1
Matrix metalloproteinase-2 and matrix metalloproteinase-9 in mice with ocular toxocariasis. ( 30631927 )
2019
2
Human toxocariasis and neutering cats. ( 30765587 )
2019
3
Correction: Human toxocariasis and neutering cats. ( 30792332 )
2019
4
Case Report: Ocular Toxocariasis: A Report of Three Cases from the Mississippi Delta. ( 30860012 )
2019
5
Imaging of toxocariasis. ( 30861557 )
2019
6
The serodiagnostic potential of recombinant proteins TES-30 and TES-120 in an indirect ELISA in the diagnosis of toxocariasis in cattle, horses, and sheep. ( 30870519 )
2019
7
Prevalence of toxocariasis and its related risk factors in humans, dogs and cats in northeastern Iran: a population-based study. ( 30892638 )
2019
8
Toxocariasis: critical analysis of serology in patients attending a public referral center for ophthalmology in Brazil. ( 29071468 )
2018
9
Low incidence of helminth infections (schistosomiasis, strongyloidiasis, filariasis, toxocariasis) among Dutch long-term travelers: A prospective study, 2008-2011. ( 29847574 )
2018
10
Epidemiological, clinical and laboratory features of toxocariasis in school children from Aragua State, Venezuela. ( 29917157 )
2018
11
A Lateral Flow Rapid Test for Human Toxocariasis Developed Using Three<i>Toxocara canis</i>Recombinant Antigens. ( 29141740 )
2018
12
Toxocariasis of the eye. ( 29942786 )
2018
13
Diagnosis of ocular toxocariasis by detecting antibodies in the vitreous humor. ( 29402497 )
2018
14
Neglected parasitic infection: toxocariasis. ( 29540354 )
2018
15
Toxocariasis: a silent threat with a progressive public health impact. ( 29895324 )
2018
16
Endocrine immune interactions during chronic Toxocariasis caused by Toxocara canis in a murine model: New insights into the pathophysiology of an old infection. ( 29559144 )
2018
17
Updated evidence of the association between toxocariasis and epilepsy: Systematic review and meta-analysis. ( 30028858 )
2018
18
Myelitis and tenosynovitis attributed to toxocariasis. ( 30273660 )
2018
19
Toxocariasis in Carnivora from Argentinean Patagonia: Species molecular identification, hosts, and geographical distribution. ( 29988800 )
2018
20
Getting to the bottom of toxocariasis prevention. ( 30122621 )
2018
21
Prognosis for ocular toxocariasis according to granuloma location. ( 30161178 )
2018
22
Clinical course and treatment outcomes of toxocariasis-related eosinophilic disorder. ( 30212995 )
2018
23
Ocular toxocariasis in a pediatric patient undergoing a bone marrow transplantation. ( 30360919 )
2018
24
Clinical and laboratory characteristics of patients with toxocariasis encountered at a tertiary care centre in North India. ( 30429401 )
2018
25
Correction: Prognosis for ocular toxocariasis according to granuloma location. ( 30440045 )
2018
26
New insight into the diagnostic cut-off value of serum anti-Toxocara IgG for ocular toxocariasis in uveitis patients. ( 30457059 )
2018
27
Risk factors and prevalence of toxocariasis in pregnant women and diabetic patients compared to healthy adults in Ilam province, western Iran. ( 30564078 )
2018
28
Clinical usefulness of Western blotting and ELISA avidity for the diagnosis of human toxocariasis. ( 27809350 )
2017
29
Seroprevalence of Toxocariasis In Children With Urticaria: A Population-Based Study. ( 28077610 )
2017
30
Toxocariasis in Africa: A One Health perspective. ( 29128441 )
2017
31
Prevalence of Toxocara antibodies among patients clinically suspected to have ocular toxocariasis: A retrospective descriptive study in Sri Lanka. ( 28438141 )
2017
32
Evaluation of the prevalence and clinical impact of toxocariasis in patients with eosinophilia of unknown origin. ( 28352060 )
2017
33
Assessment of U.S. Pediatrician Knowledge of Toxocariasis. ( 28820703 )
2017
34
Frequency of Toxocariasis among Patients Clinically Suspected to Have Visceral Toxocariasis: A Retrospective Descriptive Study in Sri Lanka. ( 29362672 )
2017
35
Toxocariasis in humans in Africa - A systematic review. ( 29037977 )
2017
36
Global toxocariasis research trends from 1932 to 2015: a bibliometric analysis. ( 28231792 )
2017
37
Experimental toxocariasis in BALB/c mice: relationship between parasite inoculum and the IgG immune response. ( 28443979 )
2017
38
Role of ultrasound biomicroscopy in diagnosis of ocular toxocariasis. ( 28928264 )
2017
39
Enhanced expressions of neurodegeneration-associated factors, UPS impairment, and excess AI^ accumulation in the hippocampus of mice with persistent cerebral toxocariasis. ( 29273062 )
2017
40
Trend of toxocariasis in Iran: a review on human and animal dimensions. ( 29387094 )
2017
41
The 33.1 kDa Excretory/secretory Protein Produced by Toxocara canis Larvae Serves as a Potential Common Biomarker for Serodiagnosis of Toxocariasis in Paratenic Animals and Human. ( 28761463 )
2017
42
Association between intermediate uveitis and toxocariasis in the Korean population. ( 28151857 )
2017
43
Ultrasound biomicroscopic imaging in paediatric ocular toxocariasis. ( 28302681 )
2017
44
Immunoglobulin M antibodies are not specific for serodiagnosis of human toxocariasis. ( 28543101 )
2017
45
Toxocariasis of the central nervous system: With report of two cases. ( 28157623 )
2017
46
Abdominal Mass Secondary to Human Toxocariasis. ( 28164001 )
2017
47
Evaluation of the transcription of interleukin-12 in the intestinal mucosa of mice subjected to experimental toxocariasis and supplemented with Saccharomyces boulardii. ( 28606326 )
2017
48
Human toxocariasis. ( 28781085 )
2017
49
Hepatic Visceral Larva Migrans Causing Hepatic Venous Thrombosis and Prolonged Fever. ( 29120339 )
2017
50
Invasive toxocariasis with hepatic lesions. ( 27692829 )
2016

Variations for Toxocariasis

Expression for Toxocariasis

Search GEO for disease gene expression data for Toxocariasis.

Pathways for Toxocariasis

Pathways related to Toxocariasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.07 SLC44A1 SLC44A2

GO Terms for Toxocariasis

Biological processes related to Toxocariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylcholine biosynthetic process GO:0006656 8.96 SLC44A1 SLC44A2
2 choline transport GO:0015871 8.62 SLC44A1 SLC44A2

Molecular functions related to Toxocariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 choline transmembrane transporter activity GO:0015220 8.62 SLC44A1 SLC44A2

Sources for Toxocariasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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