MCID: TXC011
MIFTS: 39

Toxocariasis

Categories: Cardiovascular diseases, Endocrine diseases, Eye diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases, Muscle diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Toxocariasis

MalaCards integrated aliases for Toxocariasis:

Name: Toxocariasis 12 76 53 59 55 3 44 15 73
Larva Migrans, Visceral 44 73
Infection by Toxascaris 12
Visceral Larva Migrans 12
Larva Migrans Visceral 55
Toxocara Infection 12

Characteristics:

Orphanet epidemiological data:

59
toxocariasis
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9790
ICD10 33 B83.0
NCIt 50 C34758
SNOMED-CT 68 87121004
Orphanet 59 ORPHA3343
MESH via Orphanet 45 D014120
UMLS via Orphanet 74 C0040553
ICD10 via Orphanet 34 B83.0

Summaries for Toxocariasis

NIH Rare Diseases : 53 Toxocariasis is a parasitic condition caused by the larvae of two species of Toxocara roundworms: Toxocara canis (from dogs) and Toxocara cati (from cats). Many people who are infected with Toxocara never develop any signs or symptoms of the condition. In those who do become sick, symptoms may present as: Ocular Toxocariasis - when the larvae infect the eye and cause vision loss, eye inflammation, and/or damage to the retina. Visceral Toxocariasis - when the larvae infect various organs of the body (i.e. the liver or the central nervous system) and cause fever, fatigue, coughing, wheezing, and/or abdominal pain. Toxocariasis is generally spread through dirt that has been contaminated with animal feces that contain infectious Toxocara eggs. Young children and owners of dogs and cats have a higher chance of becoming infected. Visceral toxocariasis is treated with antiparasitic medications. Treatment of ocular toxocariasis is more difficult and usually consists of measures to prevent progressive damage to the eye. 

MalaCards based summary : Toxocariasis, also known as larva migrans, visceral, is related to schistosomiasis and urticaria. An important gene associated with Toxocariasis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways is Synthesis of PC. The drugs Albendazole and Anthelmintics have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and lung.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves zoonotic infection of humans by the larvae of Toxocara canis or Toxocara cati. The larvae invade multiple tissues like liver, heart, lungs, brain, muscle and eyes causing various symptoms including fever, anorexia, weight loss, cough, wheezing, rashes, hepatosplenomegaly, hypereosinophilia and ophthalmologic lesions.

CDC : 3 Toxocariasis is the parasitic disease caused by the larvae of two species of Toxocara roundworms: Toxocara canis from dogs and, less commonly, Toxocara cati from cats. Toxocariasis is considered one of the Neglected Parasitic Infections, a group of five parasitic diseases that have been targeted by CDC for public health action.

Wikipedia : 76 Toxocariasis is an illness of humans caused by larvae (immature worms) of either the dog roundworm... more...

Related Diseases for Toxocariasis

Diseases related to Toxocariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 schistosomiasis 30.2 IGHE RNASE3
2 urticaria 30.2 IGHE RNASE3
3 allergic asthma 29.7 IGHE RNASE3
4 hypereosinophilic syndrome 29.7 IGHE RNASE3
5 baylisascariasis 11.4
6 gnathomiasis 11.4
7 retinal vasculitis 11.4
8 baylisascaris infection 11.4
9 eosinophilic granuloma 10.3
10 cysticercosis 10.2
11 toxoplasmosis 10.2
12 atopic keratoconjunctivitis 10.1 IGHE RNASE3
13 latex allergy 10.1 IGHE RNASE3
14 epilepsy 10.1
15 vernal conjunctivitis 10.1 IGHE RNASE3
16 thrombophilia due to thrombin defect 10.1
17 alcohol-related neurodevelopmental disorder 10.1
18 thrombosis 10.1
19 viral meningitis 10.1
20 capillariasis 10.1
21 gastroenteritis 10.1
22 eosinophilic gastroenteritis 10.1
23 pulmonary eosinophilia 10.1
24 chronic eosinophilic pneumonia 10.1
25 eosinophilic enteropathy 10.1
26 encephalopathy 10.1
27 respiratory allergy 10.1 IGHE RNASE3
28 ige responsiveness, atopic 10.1 IGHE RNASE3
29 bronchiolitis 10.1 IGHE RNASE3
30 otitis media 10.1 IGHE RNASE3
31 uveitis 10.1
32 conjunctival disease 10.1 MRAP RNASE3
33 proteasome-associated autoinflammatory syndrome 1 10.1 IGHE RNASE3
34 asthma 10.0
35 neuroretinitis 10.0
36 strongyloidiasis 10.0
37 allergic hypersensitivity disease 10.0 IGHE RNASE3
38 rhinitis 10.0 IGHE RNASE3
39 filariasis 10.0
40 parasitic protozoa infectious disease 10.0 FARSA TCN2
41 choline deficiency disease 10.0 SLC44A1 SLC44A2
42 allergic rhinitis 9.9 IGHE RNASE3
43 chorioretinitis 9.9 MRAP SLC44A2
44 retinoblastoma 9.9
45 ascaris lumbricoides infection 9.9
46 arthritis 9.9
47 eosinophilic meningitis 9.9
48 dirofilariasis 9.9
49 echinococcosis 9.9
50 ascaridiasis 9.9

Comorbidity relations with Toxocariasis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease

Graphical network of the top 20 diseases related to Toxocariasis:



Diseases related to Toxocariasis

Symptoms & Phenotypes for Toxocariasis

Drugs & Therapeutics for Toxocariasis

Drugs for Toxocariasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
2 Anthelmintics Phase 3
3 Antiprotozoal Agents Phase 3
4 Anti-Infective Agents Phase 3
5 Antiparasitic Agents Phase 3
6 Antimitotic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Asymptomatic Toxocariasis With Albendazole in Children Unknown status NCT00755560 Phase 3 Albendazole;Placebo
2 A Study for the Ocular Toxocariasis Patients With the Pulmonary Toxocariasis, and Ocular Toxocariasis Cohort Recruiting NCT03814837

Search NIH Clinical Center for Toxocariasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: toxocariasis

Genetic Tests for Toxocariasis

Anatomical Context for Toxocariasis

MalaCards organs/tissues related to Toxocariasis:

41
Eye, Liver, Lung, Brain, Retina, Heart, Testes

Publications for Toxocariasis

Articles related to Toxocariasis:

(show top 50) (show all 574)
# Title Authors Year
1
Toxocariasis: critical analysis of serology in patients attending a public referral center for ophthalmology in Brazil. ( 29071468 )
2018
2
Low incidence of helminth infections (schistosomiasis, strongyloidiasis, filariasis, toxocariasis) among Dutch long-term travelers: A prospective study, 2008-2011. ( 29847574 )
2018
3
Epidemiological, clinical and laboratory features of toxocariasis in school children from Aragua State, Venezuela. ( 29917157 )
2018
4
A Lateral Flow Rapid Test for Human Toxocariasis Developed Using Three<i>Toxocara canis</i>Recombinant Antigens. ( 29141740 )
2018
5
Toxocariasis of the eye. ( 29942786 )
2018
6
Diagnosis of ocular toxocariasis by detecting antibodies in the vitreous humor. ( 29402497 )
2018
7
Neglected parasitic infection: toxocariasis. ( 29540354 )
2018
8
Updated evidence of the association between toxocariasis and epilepsy: Systematic review and meta-analysis. ( 30028858 )
2018
9
Myelitis and tenosynovitis attributed to toxocariasis. ( 30273660 )
2018
10
Human toxocariasis. ( 28781085 )
2018
11
Endocrine immune interactions during chronic Toxocariasis caused by Toxocara canis in a murine model: New insights into the pathophysiology of an old infection. ( 29559144 )
2018
12
Toxocariasis: a silent threat with a progressive public health impact. ( 29895324 )
2018
13
Toxocariasis in Carnivora from Argentinean Patagonia: Species molecular identification, hosts, and geographical distribution. ( 29988800 )
2018
14
Getting to the bottom of toxocariasis prevention. ( 30122621 )
2018
15
Prognosis for ocular toxocariasis according to granuloma location. ( 30161178 )
2018
16
Clinical course and treatment outcomes of toxocariasis-related eosinophilic disorder. ( 30212995 )
2018
17
Ocular toxocariasis in a pediatric patient undergoing a bone marrow transplantation. ( 30360919 )
2018
18
Clinical and laboratory characteristics of patients with toxocariasis encountered at a tertiary care centre in North India. ( 30429401 )
2018
19
Correction: Prognosis for ocular toxocariasis according to granuloma location. ( 30440045 )
2018
20
New insight into the diagnostic cut-off value of serum anti-Toxocara IgG for ocular toxocariasis in uveitis patients. ( 30457059 )
2018
21
Clinical usefulness of Western blotting and ELISA avidity for the diagnosis of human toxocariasis. ( 27809350 )
2017
22
Seroprevalence of Toxocariasis In Children With Urticaria: A Population-Based Study. ( 28077610 )
2017
23
Toxocariasis in Africa: A One Health perspective. ( 29128441 )
2017
24
Prevalence of Toxocara antibodies among patients clinically suspected to have ocular toxocariasis: A retrospective descriptive study in Sri Lanka. ( 28438141 )
2017
25
Evaluation of the prevalence and clinical impact of toxocariasis in patients with eosinophilia of unknown origin. ( 28352060 )
2017
26
Assessment of U.S. Pediatrician Knowledge of Toxocariasis. ( 28820703 )
2017
27
Frequency of Toxocariasis among Patients Clinically Suspected to Have Visceral Toxocariasis: A Retrospective Descriptive Study in Sri Lanka. ( 29362672 )
2017
28
Toxocariasis in humans in Africa - A systematic review. ( 29037977 )
2017
29
Global toxocariasis research trends from 1932 to 2015: a bibliometric analysis. ( 28231792 )
2017
30
Experimental toxocariasis in BALB/c mice: relationship between parasite inoculum and the IgG immune response. ( 28443979 )
2017
31
Role of ultrasound biomicroscopy in diagnosis of ocular toxocariasis. ( 28928264 )
2017
32
Enhanced expressions of neurodegeneration-associated factors, UPS impairment, and excess AI^ accumulation in the hippocampus of mice with persistent cerebral toxocariasis. ( 29273062 )
2017
33
Trend of toxocariasis in Iran: a review on human and animal dimensions. ( 29387094 )
2017
34
The 33.1 kDa Excretory/secretory Protein Produced by Toxocara canis Larvae Serves as a Potential Common Biomarker for Serodiagnosis of Toxocariasis in Paratenic Animals and Human. ( 28761463 )
2017
35
Association between intermediate uveitis and toxocariasis in the Korean population. ( 28151857 )
2017
36
Ultrasound biomicroscopic imaging in paediatric ocular toxocariasis. ( 28302681 )
2017
37
Immunoglobulin M antibodies are not specific for serodiagnosis of human toxocariasis. ( 28543101 )
2017
38
Toxocariasis of the central nervous system: With report of two cases. ( 28157623 )
2017
39
Abdominal Mass Secondary to Human Toxocariasis. ( 28164001 )
2017
40
Evaluation of the transcription of interleukin-12 in the intestinal mucosa of mice subjected to experimental toxocariasis and supplemented with Saccharomyces boulardii. ( 28606326 )
2017
41
Hepatic Visceral Larva Migrans Causing Hepatic Venous Thrombosis and Prolonged Fever. ( 29120339 )
2017
42
Invasive toxocariasis with hepatic lesions. ( 27692829 )
2016
43
Intravitreal Administration of Ranibizumab and Bevacizumab for Choroidal Neovascularization Secondary to Ocular Toxocariasis: A Case Report. ( 27775459 )
2016
44
A Systematic Review of Toxocariasis: A Neglected but High-Prevalence Disease in Brazil. ( 26834201 )
2016
45
Production and evaluation of the recombinant antigen TES-30 of Toxocara canis for the immunodiagnosis of toxocariasis. ( 27622437 )
2016
46
Ocular toxocariasis presenting as bilateral scleritis with suspect retinal granuloma in the nerve fiber layer: a case report. ( 27538451 )
2016
47
Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis in blood samples diagnosed in Medic Medical Center Laboratory, Ho Chi Minh City, Vietnam in 2012. ( 27595647 )
2016
48
Evaluation of a di-O-methylated glycan as a potential antigenic target for the serodiagnosis of human toxocariasis. ( 26896376 )
2016
49
Eosinophilic Myocarditis due to Toxocariasis: Not a Rare Cause. ( 27123346 )
2016
50
Risk and other factors associated with toxoplasmosis and toxocariasis in pregnant women from southern Brazil. ( 27411883 )
2016

Variations for Toxocariasis

Expression for Toxocariasis

Search GEO for disease gene expression data for Toxocariasis.

Pathways for Toxocariasis

Pathways related to Toxocariasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.07 SLC44A1 SLC44A2

GO Terms for Toxocariasis

Biological processes related to Toxocariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylcholine biosynthetic process GO:0006656 8.96 SLC44A1 SLC44A2
2 choline transport GO:0015871 8.62 SLC44A1 SLC44A2

Molecular functions related to Toxocariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 choline transmembrane transporter activity GO:0015220 8.62 SLC44A1 SLC44A2

Sources for Toxocariasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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