MCID: TXC011
MIFTS: 42

Toxocariasis

Categories: Cardiovascular diseases, Endocrine diseases, Eye diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases, Muscle diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Toxocariasis

MalaCards integrated aliases for Toxocariasis:

Name: Toxocariasis 12 77 54 60 56 3 45 15 17 74
Larva Migrans, Visceral 45 74
Infection by Toxascaris 12
Visceral Larva Migrans 12
Larva Migrans Visceral 56
Toxocara Infection 12

Characteristics:

Orphanet epidemiological data:

60
toxocariasis
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9790
NCIt 51 C34758
SNOMED-CT 69 87121004
ICD10 34 B83.0
MESH via Orphanet 46 D014120
ICD10 via Orphanet 35 B83.0
UMLS via Orphanet 75 C0040553
Orphanet 60 ORPHA3343

Summaries for Toxocariasis

NIH Rare Diseases : 54 Toxocariasis is a parasitic condition caused by the larvae of two species of Toxocara roundworms: Toxocara canis (from dogs) and Toxocara cati (from cats). Many people who are infected with Toxocara never develop any signs or symptoms of the condition. In those who do become sick, symptoms may present as: Ocular Toxocariasis - when the larvae infect the eye and cause vision loss, eye inflammation, and/or damage to the retina. Visceral Toxocariasis - when the larvae infect various organs of the body (i.e. the liver or the central nervous system) and cause fever, fatigue, coughing, wheezing, and/or abdominal pain. Toxocariasis is generally spread through dirt that has been contaminated with animal feces that contain infectious Toxocara eggs. Young children and owners of dogs and cats have a higher chance of becoming infected. Visceral toxocariasis is treated with antiparasitic medications. Treatment of ocular toxocariasis is more difficult and usually consists of measures to prevent progressive damage to the eye. 

MalaCards based summary : Toxocariasis, also known as larva migrans, visceral, is related to hypereosinophilic syndrome and schistosomiasis. An important gene associated with Toxocariasis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways is Synthesis of PC. The drugs Albendazole and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and retina.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves zoonotic infection of humans by the larvae of Toxocara canis or Toxocara cati. The larvae invade multiple tissues like liver, heart, lungs, brain, muscle and eyes causing various symptoms including fever, anorexia, weight loss, cough, wheezing, rashes, hepatosplenomegaly, hypereosinophilia and ophthalmologic lesions.

CDC : 3 Image: Various stages of Toxocara canis larva hatching. Credit: DPDx

Wikipedia : 77 Toxocariasis is an illness of humans caused by larvae (immature worms) of either the dog roundworm... more...

Related Diseases for Toxocariasis

Diseases related to Toxocariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 hypereosinophilic syndrome 30.7 IGHE RNASE3
2 schistosomiasis 30.4 IGHE RNASE3
3 urticaria 30.3 IGHE RNASE3
4 allergic asthma 29.9 IGHE RNASE3
5 baylisascariasis 11.4
6 gnathomiasis 11.4
7 retinal vasculitis 11.4
8 baylisascaris infection 11.4
9 eosinophilic granuloma 10.3
10 cysticercosis 10.3
11 ascaris lumbricoides infection 10.2
12 ascaridiasis 10.2
13 atopic keratoconjunctivitis 10.2 IGHE RNASE3
14 latex allergy 10.2 IGHE RNASE3
15 vernal conjunctivitis 10.2 IGHE RNASE3
16 respiratory allergy 10.2 IGHE RNASE3
17 toxoplasmosis 10.2
18 ige responsiveness, atopic 10.2 IGHE RNASE3
19 bronchiolitis 10.2 IGHE RNASE3
20 uveitis 10.2
21 epilepsy 10.2
22 otitis media 10.2 IGHE RNASE3
23 thrombophilia due to thrombin defect 10.1
24 alcohol-related neurodevelopmental disorder 10.1
25 thrombosis 10.1
26 viral meningitis 10.1
27 meningoencephalitis 10.1
28 japanese encephalitis 10.1
29 hemiplegia 10.1
30 capillariasis 10.1
31 rheumatic disease 10.1
32 cholecystitis 10.1
33 gastroenteritis 10.1
34 eosinophilic gastroenteritis 10.1
35 pulmonary eosinophilia 10.1
36 chronic eosinophilic pneumonia 10.1
37 encephalitis 10.1
38 eosinophilic enteropathy 10.1
39 encephalopathy 10.1
40 proteasome-associated autoinflammatory syndrome 1 10.1 IGHE RNASE3
41 conjunctival disease 10.1 MRAP RNASE3
42 asthma 10.1
43 neuroretinitis 10.1
44 strongyloidiasis 10.1
45 echinococcosis 10.1
46 allergic hypersensitivity disease 10.1 IGHE RNASE3
47 parasitic protozoa infectious disease 10.0 FARSA TCN2
48 rhinitis 10.0 IGHE RNASE3
49 poliomyelitis 10.0
50 filariasis 10.0

Comorbidity relations with Toxocariasis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease

Graphical network of the top 20 diseases related to Toxocariasis:



Diseases related to Toxocariasis

Symptoms & Phenotypes for Toxocariasis

Drugs & Therapeutics for Toxocariasis

Drugs for Toxocariasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
2 Anti-Infective Agents Phase 3
3 Antimitotic Agents Phase 3
4 Antiparasitic Agents Phase 3
5 Antiprotozoal Agents Phase 3
6 Anthelmintics Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Asymptomatic Toxocariasis With Albendazole in Children Unknown status NCT00755560 Phase 3 Albendazole;Placebo
2 A Study for the Ocular Toxocariasis Patients With the Pulmonary Toxocariasis, and Ocular Toxocariasis Cohort Recruiting NCT03814837

Search NIH Clinical Center for Toxocariasis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: toxocariasis

Genetic Tests for Toxocariasis

Anatomical Context for Toxocariasis

MalaCards organs/tissues related to Toxocariasis:

42
Eye, Brain, Retina, Testes, Skin, Spinal Cord, Bone Marrow

Publications for Toxocariasis

Articles related to Toxocariasis:

(show top 50) (show all 595)
# Title Authors Year
1
A serological survey of echinococcosis, toxocariasis and trichinellosis among rural inhabitants of Central Yakutia. ( 31046654 )
2019
2
Myelitis and tenosynovitis attributed to toxocariasis. ( 30273660 )
2019
3
Eosinophilic panniculitis associated with toxocariasis in a child. ( 31090841 )
2019
4
The serodiagnostic potential of recombinant proteins TES-30 and TES-120 in an indirect ELISA in the diagnosis of toxocariasis in cattle, horses, and sheep. ( 30870519 )
2019
5
Prevalence of toxocariasis and its related risk factors in humans, dogs and cats in northeastern Iran: a population-based study. ( 30892638 )
2019
6
Human toxocariasis seroprevalence among patients with uveitis in Alborz Province, Iran. ( 30922047 )
2019
7
Ocular toxocariasis: atypical clinical course. ( 30948413 )
2019
8
Toxocara vitulorum cuticle glycoproteins in the diagnosis of calves' toxocariasis. ( 31040572 )
2019
9
Matrix metalloproteinase-2 and matrix metalloproteinase-9 in mice with ocular toxocariasis. ( 30631927 )
2019
10
Human toxocariasis and neutering cats. ( 30765587 )
2019
11
Correction: Human toxocariasis and neutering cats. ( 30792332 )
2019
12
Case Report: Ocular Toxocariasis: A Report of Three Cases from the Mississippi Delta. ( 30860012 )
2019
13
Imaging of toxocariasis. ( 30861557 )
2019
14
Updated evidence of the association between toxocariasis and epilepsy: Systematic review and meta-analysis. ( 30028858 )
2018
15
Low incidence of helminth infections (schistosomiasis, strongyloidiasis, filariasis, toxocariasis) among Dutch long-term travelers: A prospective study, 2008-2011. ( 29847574 )
2018
16
Intravitreal Administration of Ranibizumab and Bevacizumab for Choroidal Neovascularization Secondary to Ocular Toxocariasis: A Case Report. ( 27775459 )
2018
17
Human toxocariasis. ( 28781085 )
2018
18
Role of ultrasound biomicroscopy in diagnosis of ocular toxocariasis. ( 28928264 )
2018
19
Toxocariasis: critical analysis of serology in patients attending a public referral center for ophthalmology in Brazil. ( 29071468 )
2018
20
A Lateral Flow Rapid Test for Human Toxocariasis Developed Using Three Toxocara canis Recombinant Antigens. ( 29141740 )
2018
21
Diagnosis of ocular toxocariasis by detecting antibodies in the vitreous humor. ( 29402497 )
2018
22
Neglected parasitic infection: toxocariasis. ( 29540354 )
2018
23
Endocrine immune interactions during chronic Toxocariasis caused by Toxocara canis in a murine model: New insights into the pathophysiology of an old infection. ( 29559144 )
2018
24
Toxocariasis: a silent threat with a progressive public health impact. ( 29895324 )
2018
25
Epidemiological, clinical and laboratory features of toxocariasis in school children from Aragua State, Venezuela. ( 29917157 )
2018
26
Toxocariasis of the eye. ( 29942786 )
2018
27
Toxocariasis in Carnivora from Argentinean Patagonia: Species molecular identification, hosts, and geographical distribution. ( 29988800 )
2018
28
Getting to the bottom of toxocariasis prevention. ( 30122621 )
2018
29
Prognosis for ocular toxocariasis according to granuloma location. ( 30161178 )
2018
30
Clinical course and treatment outcomes of toxocariasis-related eosinophilic disorder. ( 30212995 )
2018
31
Ocular toxocariasis in a pediatric patient undergoing a bone marrow transplantation. ( 30360919 )
2018
32
Clinical and laboratory characteristics of patients with toxocariasis encountered at a tertiary care centre in North India. ( 30429401 )
2018
33
Correction: Prognosis for ocular toxocariasis according to granuloma location. ( 30440045 )
2018
34
New insight into the diagnostic cut-off value of serum anti-Toxocara IgG for ocular toxocariasis in uveitis patients. ( 30457059 )
2018
35
Risk factors and prevalence of toxocariasis in pregnant women and diabetic patients compared to healthy adults in Ilam province, western Iran. ( 30564078 )
2018
36
Association between intermediate uveitis and toxocariasis in the Korean population. ( 28151857 )
2017
37
Hepatic Visceral Larva Migrans Causing Hepatic Venous Thrombosis and Prolonged Fever. ( 29120339 )
2017
38
Risk and other factors associated with toxoplasmosis and toxocariasis in pregnant women from southern Brazil. ( 27411883 )
2017
39
Invasive toxocariasis with hepatic lesions. ( 27692829 )
2017
40
Clinical usefulness of Western blotting and ELISA avidity for the diagnosis of human toxocariasis. ( 27809350 )
2017
41
Seroprevalence of Toxocariasis in Children with Urticaria: A Population-based Study. ( 28077610 )
2017
42
Toxocariasis of the central nervous system: With report of two cases. ( 28157623 )
2017
43
Abdominal Mass Secondary to Human Toxocariasis. ( 28164001 )
2017
44
Global toxocariasis research trends from 1932 to 2015: a bibliometric analysis. ( 28231792 )
2017
45
Ultrasound biomicroscopic imaging in paediatric ocular toxocariasis. ( 28302681 )
2017
46
Evaluation of the prevalence and clinical impact of toxocariasis in patients with eosinophilia of unknown origin. ( 28352060 )
2017
47
Prevalence of Toxocara antibodies among patients clinically suspected to have ocular toxocariasis: A retrospective descriptive study in Sri Lanka. ( 28438141 )
2017
48
Experimental toxocariasis in BALB/c mice: relationship between parasite inoculum and the IgG immune response. ( 28443979 )
2017
49
Immunoglobulin M antibodies are not specific for serodiagnosis of human toxocariasis. ( 28543101 )
2017
50
Evaluation of the transcription of interleukin-12 in the intestinal mucosa of mice subjected to experimental toxocariasis and supplemented with Saccharomyces boulardii. ( 28606326 )
2017

Variations for Toxocariasis

Expression for Toxocariasis

Search GEO for disease gene expression data for Toxocariasis.

Pathways for Toxocariasis

Pathways related to Toxocariasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.07 SLC44A1 SLC44A2

GO Terms for Toxocariasis

Biological processes related to Toxocariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylcholine biosynthetic process GO:0006656 8.96 SLC44A1 SLC44A2
2 choline transport GO:0015871 8.62 SLC44A1 SLC44A2

Molecular functions related to Toxocariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 choline transmembrane transporter activity GO:0015220 8.62 SLC44A1 SLC44A2

Sources for Toxocariasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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