MCID: TXC011
MIFTS: 41

Toxocariasis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Toxocariasis

MalaCards integrated aliases for Toxocariasis:

Name: Toxocariasis 12 76 53 59 55 3 15 73
Larva Migrans, Visceral 44 73
Infection by Toxascaris 12
Visceral Larva Migrans 12
Larva Migrans Visceral 55
Toxocara Infection 12

Characteristics:

Orphanet epidemiological data:

59
toxocariasis
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9790
ICD10 33 B83.0
MeSH 44 D007816
NCIt 50 C34758
SNOMED-CT 68 87121004
Orphanet 59 ORPHA3343
MESH via Orphanet 45 D014120
UMLS via Orphanet 74 C0040553
ICD10 via Orphanet 34 B83.0

Summaries for Toxocariasis

NIH Rare Diseases : 53 Toxocariasis is a parasitic condition caused by the larvae of two species of Toxocara roundworms: Toxocara canis (from dogs) and Toxocara cati (from cats). Many people who are infected with Toxocara never develop any signs or symptoms of the condition. In those who do become sick, symptoms may present as: Ocular Toxocariasis - when the larvae infect the eye and cause vision loss, eye inflammation, and/or damage to the retina. Visceral Toxocariasis - when the larvae infect various organs of the body (i.e. the liver or the central nervous system) and cause fever, fatigue, coughing, wheezing, and/or abdominal pain. Toxocariasis is generally spread through dirt that has been contaminated with animal feces that contain infectious Toxocara eggs. Young children and owners of dogs and cats have a higher chance of becoming infected. Visceral toxocariasis is treated with antiparasitic medications. Treatment of ocular toxocariasis is more difficult and usually consists of measures to prevent progressive damage to the eye. 

MalaCards based summary : Toxocariasis, also known as larva migrans, visceral, is related to neuroretinitis and ocular toxoplasmosis. An important gene associated with Toxocariasis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are IL4-mediated signaling events and Synthesis of PC. The drugs Albendazole and Anthelmintics have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and lung.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves zoonotic infection of humans by the larvae of Toxocara canis or Toxocara cati. The larvae invade multiple tissues like liver, heart, lungs, brain, muscle and eyes causing various symptoms including fever, anorexia, weight loss, cough, wheezing, rashes, hepatosplenomegaly, hypereosinophilia and ophthalmologic lesions.

CDC : 3 Toxocariasis is the parasitic disease caused by the larvae of two species of Toxocara roundworms: Toxocara canis from dogs and, less commonly, Toxocara cati from cats. Toxocariasis is considered one of the Neglected Parasitic Infections, a group of five parasitic diseases that have been targeted by CDC for public health action.

Wikipedia : 76 Toxocariasis is an illness of humans caused by larvae (immature worms) of either the dog roundworm... more...

Related Diseases for Toxocariasis

Diseases related to Toxocariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 neuroretinitis 30.2 CD40LG RNASE3
2 ocular toxoplasmosis 29.8 CD40LG IGHE
3 schistosomiasis 29.6 CD40LG IGHE RNASE3
4 allergic asthma 29.6 IGHE RNASE3
5 hypereosinophilic syndrome 29.5 IGHE RNASE3
6 gnathomiasis 11.2
7 retinal vasculitis 11.2
8 baylisascaris infection 11.2
9 atopic keratoconjunctivitis 10.5 IGHE RNASE3
10 latex allergy 10.4 IGHE RNASE3
11 gastrointestinal allergy 10.4 IGHE RNASE3
12 chronic interstitial cystitis 10.3 CD40LG RNASE3
13 episodic angioedema with eosinophilia 10.3 CD40LG IGHE
14 vasomotor rhinitis 10.3 CD40LG RNASE3
15 immunoglobulin g deficiency 10.3 CD40LG IGHE
16 ancylostomiasis 10.3 CD40LG RNASE3
17 henoch-schoenlein purpura 10.3 CD40LG RNASE3
18 ige responsiveness, atopic 10.3 IGHE RNASE3
19 immunodeficiency with hyper-igm, type 1 10.3 CD40LG IGHE
20 conjunctival disease 10.3 CD40LG RNASE3
21 choline deficiency disease 10.2 SLC44A1 SLC44A2
22 churg-strauss syndrome 10.2 CD40LG RNASE3
23 parasitic helminthiasis infectious disease 10.2 CD40LG RNASE3
24 upper respiratory tract disease 10.2 CD40LG RNASE3
25 allergic hypersensitivity disease 10.2 IGHE RNASE3
26 leukocyte disease 10.2 CD40LG RNASE3
27 bronchitis 10.1 CD40LG RNASE3
28 cerebritis 10.1
29 respiratory system disease 10.1 CD40LG RNASE3
30 cysticercosis 10.1
31 hepatitis 10.0
32 rhinitis 10.0 IGHE RNASE3
33 toxoplasmosis 10.0
34 epilepsy 9.9
35 retinitis 9.9
36 allergic rhinitis 9.9 IGHE RNASE3
37 asthma 9.9
38 strongyloidiasis 9.9
39 choroiditis 9.9
40 uveitis 9.9
41 urticaria 9.9
42 vernal conjunctivitis 9.9 CD40LG IGHE RNASE3
43 bronchiolitis 9.9 CD40LG IGHE RNASE3
44 otitis media 9.9 CD40LG IGHE RNASE3
45 aging 9.8
46 filariasis 9.8
47 fasciolopsiasis 9.8 CD40LG TCN2
48 retinoblastoma 9.7
49 arthritis 9.7
50 eosinophilic meningitis 9.7

Comorbidity relations with Toxocariasis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease

Graphical network of the top 20 diseases related to Toxocariasis:



Diseases related to Toxocariasis

Symptoms & Phenotypes for Toxocariasis

Drugs & Therapeutics for Toxocariasis

Drugs for Toxocariasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
2 Anthelmintics Phase 3
3 Anti-Infective Agents Phase 3
4 Antiparasitic Agents Phase 3
5 Antiprotozoal Agents Phase 3
6 Antimitotic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Asymptomatic Toxocariasis With Albendazole in Children Unknown status NCT00755560 Phase 3 Albendazole;Placebo

Search NIH Clinical Center for Toxocariasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: larva migrans, visceral

Genetic Tests for Toxocariasis

Anatomical Context for Toxocariasis

MalaCards organs/tissues related to Toxocariasis:

41
Eye, Liver, Lung, Retina, Brain, Heart, Testes

Publications for Toxocariasis

Articles related to Toxocariasis:

(show top 50) (show all 547)
# Title Authors Year
1
Toxocariasis: critical analysis of serology in patients attending a public referral center for ophthalmology in Brazil. ( 29071468 )
2018
2
Low incidence of helminth infections (schistosomiasis, strongyloidiasis, filariasis, toxocariasis) among Dutch long-term travelers: A prospective study, 2008-2011. ( 29847574 )
2018
3
Epidemiological, clinical and laboratory features of toxocariasis in school children from Aragua State, Venezuela. ( 29917157 )
2018
4
A Lateral Flow Rapid Test for Human Toxocariasis Developed Using Three<i>Toxocara canis</i>Recombinant Antigens. ( 29141740 )
2018
5
Toxocariasis of the eye. ( 29942786 )
2018
6
Diagnosis of ocular toxocariasis by detecting antibodies in the vitreous humor. ( 29402497 )
2018
7
Neglected parasitic infection: toxocariasis. ( 29540354 )
2018
8
Toxocariasis: a silent threat with a progressive public health impact. ( 29895324 )
2018
9
Endocrine immune interactions during chronic Toxocariasis caused by Toxocara canis in a murine model: New insights into the pathophysiology of an old infection. ( 29559144 )
2018
10
Clinical usefulness of Western blotting and ELISA avidity for the diagnosis of human toxocariasis. ( 27809350 )
2017
11
Seroprevalence of Toxocariasis In Children With Urticaria: A Population-Based Study. ( 28077610 )
2017
12
Toxocariasis in Africa: A One Health perspective. ( 29128441 )
2017
13
Prevalence of Toxocara antibodies among patients clinically suspected to have ocular toxocariasis: A retrospective descriptive study in Sri Lanka. ( 28438141 )
2017
14
Evaluation of the prevalence and clinical impact of toxocariasis in patients with eosinophilia of unknown origin. ( 28352060 )
2017
15
Assessment of U.S. Pediatrician Knowledge of Toxocariasis. ( 28820703 )
2017
16
Frequency of Toxocariasis among Patients Clinically Suspected to Have Visceral Toxocariasis: A Retrospective Descriptive Study in Sri Lanka. ( 29362672 )
2017
17
Toxocariasis in humans in Africa - A systematic review. ( 29037977 )
2017
18
Global toxocariasis research trends from 1932 to 2015: a bibliometric analysis. ( 28231792 )
2017
19
Experimental toxocariasis in BALB/c mice: relationship between parasite inoculum and the IgG immune response. ( 28443979 )
2017
20
Role of ultrasound biomicroscopy in diagnosis of ocular toxocariasis. ( 28928264 )
2017
21
Enhanced expressions of neurodegeneration-associated factors, UPS impairment, and excess AI^ accumulation in the hippocampus of mice with persistent cerebral toxocariasis. ( 29273062 )
2017
22
Trend of toxocariasis in Iran: a review on human and animal dimensions. ( 29387094 )
2017
23
The 33.1 kDa Excretory/secretory Protein Produced by Toxocara canis Larvae Serves as a Potential Common Biomarker for Serodiagnosis of Toxocariasis in Paratenic Animals and Human. ( 28761463 )
2017
24
Association between intermediate uveitis and toxocariasis in the Korean population. ( 28151857 )
2017
25
Ultrasound biomicroscopic imaging in paediatric ocular toxocariasis. ( 28302681 )
2017
26
Immunoglobulin M antibodies are not specific for serodiagnosis of human toxocariasis. ( 28543101 )
2017
27
Toxocariasis of the central nervous system: With report of two cases. ( 28157623 )
2017
28
Abdominal Mass Secondary to Human Toxocariasis. ( 28164001 )
2017
29
Evaluation of the transcription of interleukin-12 in the intestinal mucosa of mice subjected to experimental toxocariasis and supplemented with Saccharomyces boulardii. ( 28606326 )
2017
30
Human toxocariasis. ( 28781085 )
2017
31
Invasive toxocariasis with hepatic lesions. ( 27692829 )
2016
32
Intravitreal Administration of Ranibizumab and Bevacizumab for Choroidal Neovascularization Secondary to Ocular Toxocariasis: A Case Report. ( 27775459 )
2016
33
A Systematic Review of Toxocariasis: A Neglected but High-Prevalence Disease in Brazil. ( 26834201 )
2016
34
Production and evaluation of the recombinant antigen TES-30 of Toxocara canis for the immunodiagnosis of toxocariasis. ( 27622437 )
2016
35
Ocular toxocariasis presenting as bilateral scleritis with suspect retinal granuloma in the nerve fiber layer: a case report. ( 27538451 )
2016
36
Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis in blood samples diagnosed in Medic Medical Center Laboratory, Ho Chi Minh City, Vietnam in 2012. ( 27595647 )
2016
37
Evaluation of a di-O-methylated glycan as a potential antigenic target for the serodiagnosis of human toxocariasis. ( 26896376 )
2016
38
Eosinophilic Myocarditis due to Toxocariasis: Not a Rare Cause. ( 27123346 )
2016
39
Risk and other factors associated with toxoplasmosis and toxocariasis in pregnant women from southern Brazil. ( 27411883 )
2016
40
Clinical Characteristics of Pediatric Patients with Ocular Toxocariasis in China. ( 26760978 )
2016
41
Seroepidemiological Study of Toxocariasis in the Owners of Domestic Cats and Dogs in Mashhad, Northeastern Iran. ( 28096863 )
2016
42
[Ocular toxocariasis in a boy with idiopathic nephrotic syndrome - a case report]. ( 27760094 )
2016
43
Chronic polyarthritis as isolated manifestation of toxocariasis. ( 27267534 )
2016
44
Toxocariasis and childhood asthma: a case-control study. ( 27104477 )
2016
45
Diagnostic Value of the Serum Anti-Toxocara IgG Titer for Ocular Toxocariasis in Patients with Uveitis at a Tertiary Hospital in Korea. ( 27478352 )
2016
46
Human Toxocariasis: Prevalence and Factors Associated with Biosafety in Research Laboratories. ( 27698276 )
2016
47
Evaluation of the Goldmann-Witmer coefficient in the immunological diagnosis of ocular toxocariasis. ( 26899678 )
2016
48
Ocular Toxocariasis: Clinical Features and Long-Term Visual Outcomes in Adult Patients. ( 27066722 )
2016
49
Epidemiology of Toxocariasis in England and Wales. ( 26895794 )
2016
50
Staphylococcus aureus Endocarditis as a Complication of Toxocariasis-Associated Endomyocarditis With Fibrosis: A Case Report. ( 27800525 )
2016

Variations for Toxocariasis

Expression for Toxocariasis

Search GEO for disease gene expression data for Toxocariasis.

Pathways for Toxocariasis

Pathways related to Toxocariasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.76 CD40LG IGHE
2 10.07 SLC44A1 SLC44A2

GO Terms for Toxocariasis

Biological processes related to Toxocariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylcholine biosynthetic process GO:0006656 8.96 SLC44A1 SLC44A2
2 choline transport GO:0015871 8.62 SLC44A1 SLC44A2

Molecular functions related to Toxocariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 choline transmembrane transporter activity GO:0015220 8.62 SLC44A1 SLC44A2

Sources for Toxocariasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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