MCID: TXP001
MIFTS: 65

Toxoplasmosis

Categories: Blood diseases, Fetal diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Toxoplasmosis

MalaCards integrated aliases for Toxoplasmosis:

Name: Toxoplasmosis 12 77 56 44 45 15 17 74 3
Multisystemic Disseminated Toxoplasmosis 74
Disseminated Toxoplasmosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9965
ICD9CM 36 130 130.9
MeSH 45 D014123
NCIt 51 C3418
SNOMED-CT 69 9399000
ICD10 34 B58 B58.8 B58.9

Summaries for Toxoplasmosis

MedlinePlus : 44 Toxoplasmosis is a disease caused by the parasite Toxoplasma gondii. More than 60 million people in the U.S. have the parasite. Most of them don't get sick. But the parasite causes serious problems for some people. These include people with weak immune systems and babies whose mothers become infected for the first time during pregnancy. Problems can include damage to the brain, eyes, and other organs. You can get toxoplasmosis from Waste from an infected cat Eating contaminated meat that is raw or not well cooked Using utensils or cutting boards after they've had contact with contaminated raw meat Drinking infected water Receiving an infected organ transplant or blood transfusion Most people with toxoplasmosis don't need treatment. There are drugs to treat it for pregnant women and people with weak immune systems. Centers for Disease Control and Prevention

MalaCards based summary : Toxoplasmosis, also known as multisystemic disseminated toxoplasmosis, is related to ocular toxoplasmosis and congenital toxoplasmosis, and has symptoms including fever and pruritus. An important gene associated with Toxoplasmosis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs leucovorin and Pyrimethamine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A coccidiosis that has material basis in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

CDC : 3 However, women newly infected with Toxoplasma during or shortly before pregnancy and anyone with a compromised immune system should be aware that toxoplasmosis can have severe consequences.

Wikipedia : 77 Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii. Infections with toxoplasmosis usually... more...

Related Diseases for Toxoplasmosis

Diseases in the Toxoplasmosis family:

Congenital Toxoplasmosis

Diseases related to Toxoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 564)
# Related Disease Score Top Affiliating Genes
1 ocular toxoplasmosis 34.1 CCR5 CD40LG CD79A TLR9
2 congenital toxoplasmosis 33.6 CD40LG CD79A HLA-DQA1 HLA-DQB1 NLRP1 TLR9
3 pneumocystosis 30.7 CD40LG DHFR TNF
4 uveitis 30.4 IFNG IL10 IL4 TNF
5 rubella 30.4 CD40LG HLA-DQB1 IL10 IL4 TNF
6 cryptosporidiosis 30.3 CD40LG CD79A DHFR
7 congenital cytomegalovirus 30.2 IL1B TLR2 TNF
8 schistosomiasis 30.1 CD40LG IFNG IL10 IL4 TNF
9 variola major 30.1 IFNG TLR4
10 acquired immunodeficiency syndrome 30.1 CCR5 IFNG IL10 IL1B IL6 TNF
11 lymphadenitis 30.1 IFNG IL10 IL1B TLR4 TNF
12 cytomegalovirus infection 30.0 IL1B IL6 TNF
13 ige responsiveness, atopic 30.0 IFNG IL10 IL4
14 cryptococcosis 30.0 IFNG IL4 TLR9
15 scleritis 30.0 IFNG IL4 TNF
16 hematopoietic stem cell transplantation 30.0 IFNG IL10 IL6 TNF
17 campylobacteriosis 29.9 IFNG IL1B TLR4
18 lupus erythematosus 29.8 CD40LG IL10 NLRP1 TNF
19 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 29.8 CCR5 CD40LG IFNG IL10 IL4
20 myasthenia gravis 29.8 IFNG IL10 IL4 TNF
21 cytomegalovirus retinitis 29.7 CCR5 HLA-DQB1 IFNG TNF
22 acute disseminated encephalomyelitis 29.7 HLA-DQA1 HLA-DQB1 IL10 IL1B
23 post-transplant lymphoproliferative disease 29.7 IL10 IL6 TNF
24 immunodeficiency with hyper-igm, type 1 29.6 CD40 CD40LG CD79A IL4
25 neuritis 29.6 IFNG IL1B IL4 TNF
26 cysticercosis 29.6 IL1B IL6 TLR4
27 allergic hypersensitivity disease 29.6 IFNG IL10 IL4 TLR9
28 human immunodeficiency virus type 1 29.5 CCR5 CD40 IFNG IL10 IL6 TNF
29 posterior uveitis 29.5 IFNG IL6 TNF
30 chikungunya 29.4 IL1B IL6 TNF
31 extrinsic allergic alveolitis 29.4 IL10 IL1B IL6
32 adult respiratory distress syndrome 29.4 IL10 IL6 TNF
33 acute respiratory distress syndrome 29.4 IL1B IL6 TNF
34 viral hepatitis 29.4 HLA-DQA1 TLR2 TLR9 TNF
35 guillain-barre syndrome 29.4 CD79A HLA-DQA1 HLA-DQB1 TNF
36 human immunodeficiency virus infectious disease 29.4 CCR5 IFNG IL10 IL6 TLR9 TNF
37 glomerulonephritis 29.4 CD40LG CD79A IL1B TLR9
38 myocarditis 29.4 CD40 CD40LG HLA-DQB1 IL6 TNF
39 leptospirosis 29.3 IFNG IL10 IL1B IL6 TLR2 TNF
40 aplastic anemia 29.3 IFNG IL4 IL6 TNF
41 meningoencephalitis 29.3 CD40LG CD79A IL6 TLR9
42 juvenile rheumatoid arthritis 29.2 HLA-DQA1 IL1B IL6 TNF
43 brucellosis 29.2 CD40LG IFNG IL10 IL4 IL6 TLR4
44 coccidiosis 29.2 IFNG IL10 IL4 RHD TLR9 TNF
45 peritonitis 29.2 IL10 IL1B IL6 TLR2 TNF
46 kawasaki disease 29.1 IL10 IL6 MYD88 TNF
47 typhoid fever 29.1 IFNG IL1B IL6 TLR4 TNF
48 diabetes mellitus 29.0 CCR5 HLA-DQA1 HLA-DQB1 IFNG IL1B IL6
49 graft-versus-host disease 29.0 HLA-DQB1 IFNG IL10 IL1B IL6 TNF
50 pericarditis 29.0 IFNG IL1B IL6 TNF

Graphical network of the top 20 diseases related to Toxoplasmosis:



Diseases related to Toxoplasmosis

Symptoms & Phenotypes for Toxoplasmosis

UMLS symptoms related to Toxoplasmosis:


fever, pruritus

GenomeRNAi Phenotypes related to Toxoplasmosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 CD40LG DHFR HLA-DQB1 IL10 IL1B MYD88
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 CD40LG DHFR HLA-DQB1 IL10 IL1B MYD88

MGI Mouse Phenotypes related to Toxoplasmosis:

47 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.55 ALOX12 CCR5 CD40 CD40LG CD79A DHFR
2 homeostasis/metabolism MP:0005376 10.51 ALOX12 CCR5 CD40 CD40LG CD79A DHFR
3 immune system MP:0005387 10.5 ALOX12 CCR5 CD40 CD40LG CD79A DHFR
4 cellular MP:0005384 10.42 CCR5 CD40LG CD79A DHFR HLA-DQB1 IFNG
5 cardiovascular system MP:0005385 10.36 CCR5 CD40LG DHFR HLA-DQB1 IFNG IL10
6 mortality/aging MP:0010768 10.32 CCR5 CD40LG DHFR HLA-DQB1 IFNG IL10
7 digestive/alimentary MP:0005381 10.31 CCR5 HLA-DQB1 IFNG IL10 IL4 IL6
8 endocrine/exocrine gland MP:0005379 10.3 CD40 CD40LG HLA-DQA1 HLA-DQB1 IFNG IL10
9 integument MP:0010771 10.25 ALOX12 CD40LG DHFR IFNG IL10 IL1B
10 nervous system MP:0003631 10.25 CCR5 CD40 CD40LG CD79A HLA-DQB1 IFNG
11 liver/biliary system MP:0005370 10.24 CCR5 CD79A DHFR HLA-DQB1 IFNG IL10
12 neoplasm MP:0002006 10.13 CCR5 CD79A IFNG IL10 IL1B IL6
13 muscle MP:0005369 10.11 CCR5 DHFR HLA-DQB1 IFNG IL10 IL6
14 renal/urinary system MP:0005367 10.06 CD40 CD40LG CD79A HLA-DQB1 IFNG IL4
15 reproductive system MP:0005389 9.96 CCR5 CD40LG HLA-DQB1 IFNG IL10 IL4
16 no phenotypic analysis MP:0003012 9.85 CD79A IFNG IL10 IL4 MYD88 TNF
17 respiratory system MP:0005388 9.81 HLA-DQB1 IFNG IL10 IL4 IL6 MYD88
18 skeleton MP:0005390 9.7 CD40 CD40LG IFNG IL10 IL1B IL4
19 vision/eye MP:0005391 9.23 CCR5 IFNG IL10 IL4 IL6 MYD88

Drugs & Therapeutics for Toxoplasmosis

Drugs for Toxoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 128)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
2
Pyrimethamine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-14-0 4993
3
Sulfadiazine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 68-35-9 5215
4
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
5
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
6
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
7
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
8
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 1 155213-67-5 392622
9
Nevirapine Approved Phase 4 129618-40-2 4463
10
Levoleucovorin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68538-85-2
11
Spiramycin Approved Phase 4,Phase 3 24916-50-5
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
13
Calcium Approved, Nutraceutical Phase 4,Phase 2,Phase 1,Not Applicable 7440-70-2 271
14
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
15 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Vitamin B9 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Folate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Antimalarials Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 HIV Protease Inhibitors Phase 4,Phase 3,Phase 1
25
protease inhibitors Phase 4,Phase 3,Phase 1
26 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Hormones Phase 4,Phase 3,Phase 1,Phase 2
28 Antimanic Agents Phase 4
29 Central Nervous System Depressants Phase 4
30 Psychotropic Drugs Phase 4
31 Neurotransmitter Agents Phase 4
32 Anticonvulsants Phase 4
33 GABA Agents Phase 4
34 Tranquilizing Agents Phase 4
35 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3
36 Antiviral Agents Phase 4,Phase 3,Phase 1
37 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
38 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
39 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
40 Anti-Retroviral Agents Phase 4,Phase 3,Phase 1
41 Reverse Transcriptase Inhibitors Phase 4,Phase 3,Phase 1
42 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 1
43 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 1
44 Atazanavir Sulfate Phase 4,Phase 3,Phase 1
45 Anti-HIV Agents Phase 4,Phase 3,Phase 1
46 Micronutrients Phase 4,Phase 3,Phase 1
47 Calcium, Dietary Phase 4,Phase 2,Phase 1,Not Applicable
48 Vitamins Phase 4,Phase 3,Phase 1
49 Trace Elements Phase 4,Phase 3,Phase 1
50 Nutrients Phase 4,Phase 3,Phase 1

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 Pilot Trial of Valproate as Adjunctive Treatment for Toxoplasma Gondii Infection in Early Course Schizophrenia Completed NCT02011750 Phase 4 Sodium Valproate treatment;Placebo
2 Treatment of Cerebral Toxoplasmosis in HIV/AIDS Completed NCT00367081 Phase 4 TMX-SMX (Bactrim(R));Pyrimethamine plus Sulfadiazine plus leucoverin
3 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
4 Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis Recruiting NCT00004317 Phase 4 Leucovorin calcium;Pyrimethamine;Spiramycin;Sulfadiazine
5 Assessment of Two Therapeutic Strategies in the Treatment of Children With Congenital Toxoplasmosis Unknown status NCT01202500 Phase 3
6 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3 pyrimethamine-sulfadiazine + prednisolone;Clindamycin+Dexamethasone
7 Prevention of Congenital Toxoplasmosis With Pyrimethamine + Sulfadiazine Versus Spiramycine During Pregnancy Completed NCT01189448 Phase 3 Pyrimethamine/Sulfadiazine;Spiramycine
8 Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis Completed NCT01449877 Phase 3 Trimethoprim-Sulfamethoxazole
9 Effect of Specific Anti-Toxoplasmatic Add-on Medication in Toxoplasma Gondii Seropositive Individuals With Schizophrenia or Major Depression Completed NCT00300404 Phase 3 daraprim;pyrimethamine;folinic acid
10 A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected Patients Completed NCT00000991 Phase 3 Pentamidine isethionate;Sulfamethoxazole-Trimethoprim;Dapsone;Zidovudine
11 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3 Clotrimazole;Fluconazole
12 A Randomized Study of Daily and Intermittent Prophylactic Regimens for the Prevention of Disseminated Mycobacterium Avium Complex (MAC) and Fungal Infections in HIV-Infected Patients Completed NCT00002122 Phase 3 Azithromycin;Rifabutin;Fluconazole
13 PRINCE: Study of Atazanavir (ATV)/Ritonavir (RTV) Completed NCT01099579 Phase 3 Atazanavir powder;Ritonavir oral solution;Atazanavir capsules;Ritonavir capsules
14 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin
15 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
16 Primary Prophylaxis of Cerebral Toxoplasmosis in HIV-Infected Patients Completed NCT00000643 Phase 2 Pyrimethamine;Leucovorin calcium
17 Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis Completed NCT00000794 Phase 2 Sulfadiazine;Clarithromycin;Atovaquone;Pyrimethamine;Leucovorin calcium
18 A Open-Label Study Of CP-690,550 As Long-Term Therapy (48 Weeks) In Subjects With Crohn's Disease Completed NCT01470599 Phase 2 CP-690,550;CP-690,550
19 High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals Completed NCT00885703 Phase 1, Phase 2 Fluconazole;Amphotericin B
20 Expanded Cord Blood in Patients in Need of an Allogeneic Stem Cell Transplant Completed NCT02668315 Phase 1, Phase 2
21 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
22 Phase I Study of Pyrimethamine in Healthy Japanese and Caucasian Subjects Completed NCT03258762 Phase 1 Pyrimethamine;Calcium folinate
23 A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive Patients Completed NCT00000973 Phase 1 Pyrimethamine;Leucovorin calcium;Zidovudine
24 Antiretroviral Drug Interaction Study in Volunteers With HIV Completed NCT01479361 Phase 1 Atovaquone 750 mg twice daily;Atovaquone 1500 mg twice daily
25 A Study of Azithromycin Plus Pyrimethamine in the Treatment of a Brain Infection in Patients With AIDS Completed NCT00000966 Phase 1 Azithromycin;Pyrimethamine;Leucovorin calcium
26 A Phase I Study of Autologous, Activated CD8(+) Lymphocytes Expanded In Vitro and Infused With or Without Recombinant Interleukin-2 to Patients With AIDS or Severe ARC Completed NCT00000680 Phase 1 Zidovudine;Aldesleukin
27 A Phase I Study of Pyrimethamine in Patients With GM2 Gangliosidosis Withdrawn NCT00679744 Phase 1 Pyrimethamine
28 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Not Applicable Anti-toxoplasmosis treatment;Anti-inflammatory treatments
29 Cerebral Toxoplasmosis and AIDS Completed NCT00803621
30 A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii Infection Completed NCT00000666 Not Applicable Pyrimethamine
31 A Pilot Study of 566C80 for the Salvage Treatment of Toxoplasmic Encephalitis in Patients Infected With the Human Immunodeficiency Virus (HIV) Who Have Failed or Are Intolerant of Pyrimethamine-Sulfadiazine Completed NCT00001994 Not Applicable Atovaquone
32 A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS Completed NCT00000674 Not Applicable Pyrimethamine;Leucovorin calcium;Clindamycin
33 Toxoplasmic Encephalitis in Patients With AIDS. Treatment and Prevention of Relapse Completed NCT00002064 Not Applicable Pyrimethamine;Clindamycin
34 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697
35 Drug Exposure Registry for GSK2248761, an Investigational NNRTI Completed NCT01458132 Not Applicable GSK2248761
36 Evaluation of Brain Lesions in HIV-infected Patients for Diagnosis of Primary Central Nervous System Lymphoma Completed NCT00226304
37 Expanded Noninvasive Genomic Medical Assessment: The Enigma Study Completed NCT02787486
38 HIV Cohort Study At Johns Hopkins University, University of North Carolina at Chapel Hill and Vanderbilt University Completed NCT01339416
39 Uveitis Gene-Expression Profiling Completed NCT00874471
40 Kaiser Permanente HIV Cohort Study Completed NCT01339403
41 New Diagnostic Approach for Congenital Toxoplasmosis Recruiting NCT03385499 Not Applicable
42 Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis Recruiting NCT02863588 Not Applicable
43 Lyon Cohort of Maternal and Congenital Toxoplasma Infections Recruiting NCT02936921
44 Apheresis of Patients With Immunodeficiency Recruiting NCT01212055
45 Genetics of Uveitis Recruiting NCT02357238
46 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
47 Clinical Studies of Kikuchi's Disease Withdrawn NCT00172445 Not Applicable

Search NIH Clinical Center for Toxoplasmosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: toxoplasmosis

Genetic Tests for Toxoplasmosis

Anatomical Context for Toxoplasmosis

MalaCards organs/tissues related to Toxoplasmosis:

42
Testes, Brain, Eye, Bone, Lymph Node, Bone Marrow, T Cells

Publications for Toxoplasmosis

Articles related to Toxoplasmosis:

(show top 50) (show all 3507)
# Title Authors Year
1
Latent toxoplasmosis aggravates anxiety- and depressive-like behaviour and suggest a role of gene-environment interactions in the behavioural response to the parasite. ( 30768994 )
2019
2
Tissue and Blood Protozoa including Toxoplasmosis, Chagas disease, Leishmaniasis, Babesia, Acanthamoeba, Balamuthia, & Naegleria in Solid Organ Transplant Recipients - Guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation. ( 30900295 )
2019
3
Optical Coherence Tomography Angiography of Retinal-Choroidal Anastomosis in Toxoplasmosis Chorioretinitis. ( 30869760 )
2019
4
Maternal and Congenital Toxoplasmosis: Diagnosis and Treatment Recommendations of a French Multidisciplinary Working Group. ( 30781652 )
2019
5
Congenital toxoplasmosis and proposal of a new classification for the likelihood of primary maternal infection: analysis of 375 cases in Southeast Italy. ( 30835583 )
2019
6
Congenital toxoplasmosis in the United States: clinical and serologic findings in infants born to mothers treated during pregnancy. ( 30838974 )
2019
7
Disseminated and Congenital Toxoplasmosis in a Mother and Child With Activated PI3-Kinase δ Syndrome Type 2 (APDS2): Case Report and a Literature Review of Toxoplasma Infections in Primary Immunodeficiencies. ( 30891027 )
2019
8
Concurrent cerebral toxoplasmosis and cytomegalovirus retinitis in a patient with human immunodeficiency virus. ( 30851795 )
2019
9
Toxoplasmosis and secondary Guillain-Barré associated with ruxolitinib as graft-versus-host disease treatment. ( 30207078 )
2019
10
Cerebral toxoplasmosis after allogeneic hematopoietic stem cell transplantation diagnosed by megagenomic analysis. ( 30741826 )
2019
11
Intraocular toxoplasmosis mimicking vitreous lymphoma. ( 30765498 )
2019
12
Sero-molecular detection, multi-locus genotyping, and clinical manifestations of ocular toxoplasmosis in patients in northwest Iran. ( 30624725 )
2019
13
Effectiveness of Treatments for Ocular Toxoplasmosis. ( 30806556 )
2019
14
Type I ROP16 regulates retinal inflammatory responses during ocular toxoplasmosis. ( 30901349 )
2019
15
Immune Mediator Profile in Aqueous Humor Differs in Patients with Primary Acquired Ocular Toxoplasmosis and Recurrent Acute Ocular Toxoplasmosis. ( 30906227 )
2019
16
Congenital human toxoplasmosis caused by non-clonal Toxoplasma gondii genotypes in Argentina. ( 30304711 )
2019
17
Outbreak of toxoplasmosis in four squirrel monkeys (Saimiri sciureus) in Japan. ( 30347233 )
2019
18
Serological diagnosis of Toxoplasmosis disease using a fluorescent immunosensor with chitosan-ZnO-nanoparticles. ( 30393087 )
2019
19
Interpretation of very low avidity indices acquired with the Liaison XL Toxo IgG avidity assay in dating toxoplasmosis infection. ( 30411219 )
2019
20
Consumers' preferences for freezing of meat to prevent toxoplasmosis- A stated preference approach. ( 30448472 )
2019
21
Role of Toxoplasma IgA as Part of a Reference Panel for the Diagnosis of Acute Toxoplasmosis during Pregnancy. ( 30463899 )
2019
22
Toxoplasmosis, but not borreliosis, is associated with psychiatric disorders and symptoms - false negative findings? ( 30612843 )
2019
23
Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. ( 30624926 )
2019
24
Toxoplasmosis: The Heart of the Diagnosis. ( 30631794 )
2019
25
High burden and low awareness of toxoplasmosis in the United States. ( 30638425 )
2019
26
Disruption of P2X7 Signaling Increases Susceptibility to Cerebral Toxoplasmosis. ( 30653952 )
2019
27
Vaccination with recombinant adenoviruses expressing Toxoplasma gondii MIC3, ROP9, and SAG2 provide protective immunity against acute toxoplasmosis in mice. ( 30670302 )
2019
28
Erratum: Prevalence and risk factors of toxoplasmosis among adults in a small Brazilian city. ( 30698199 )
2019
29
Comparison of splenocyte microRNA expression profiles of pigs during acute and chronic toxoplasmosis. ( 30700253 )
2019
30
Outbreak of toxoplasmosis in a flock of domestic chickens (Gallus gallus domesticus) and guinea fowl (Numida meleagris). ( 30725180 )
2019
31
Toxoplasma gondii infection and toxoplasmosis in North Africa: a review. ( 30767889 )
2019
32
Liver transplant, toxoplasmosis and kidney stones: connecting the dots. ( 30772835 )
2019
33
Knowledge and Attitude Regarding Toxoplasmosis among Jazan University Female Students. ( 30787854 )
2019
34
Analysis of Anti-toxoplasma Immunoglobulin G and Immunoglobulin M Antibody Levels after Intervention with Curcuma Longa Extract on Early Pregnant Mice with Acute Toxoplasmosis. ( 30814832 )
2019
35
Usefulness of paired samples for the Serodiagnosis of toxoplasmosis infection in a tertiary teaching Hospital in Malaysia. ( 30819141 )
2019
36
Mortality Patterns of Toxoplasmosis and Its Comorbidities in Tanzania: A 10-Year Retrospective Hospital-Based Survey. ( 30838195 )
2019
37
Maternal Immune Response During Pregnancy and Vertical Transmission in Human Toxoplasmosis. ( 30846989 )
2019
38
Clinical Toxoplasmosis in Dogs and Cats: An Update. ( 30863754 )
2019
39
A Patient With Toxoplasmosis as a Cause of Submental Lymphadenopathy. ( 30865129 )
2019
40
Advances and Challenges in Understanding Cerebral Toxoplasmosis. ( 30873157 )
2019
41
Serological study on toxoplasmosis in the Haliti-Paresí community of the Utiariti indigenous territory, Campo Novo do Parecis, Mato Grosso, Brazil. ( 30886914 )
2019
42
Central nervous system toxoplasmosis in an immunocompetent individual. ( 30887680 )
2019
43
In vitro and in vivo evaluation of kojic acid against Toxoplasma gondii in experimental models of acute toxoplasmosis. ( 30904693 )
2019
44
The Molecular Characterization and Immunity Identification of Rhoptry Protein 22 of Toxoplasma gondii as a DNA Vaccine Candidate Against Toxoplasmosis. ( 29858559 )
2019
45
Live-attenuated Pru:I9cdpk2 strain of Toxoplasma gondii protects against acute, chronic and congenital toxoplasmosis. ( 29669003 )
2018
46
A novel chemiluminescent immunoassay based on original acridinium ester labels as better solution for diagnosis of human toxoplasmosis than conventional ELISA test. ( 29398460 )
2018
47
Toxoplasmosis submandibular lymphadenitis: Report of an unusual case with a brief review. ( 29731568 )
2018
48
Disseminated toxoplasmosis in a patient with advanced acquired immunodeficiency syndrome. ( 29588907 )
2018
49
Ocular toxoplasmosis: adverse reactions to treatment in a Brazilian cohort. ( 29788193 )
2018
50
Pediatric Amazonian Toxoplasmosis Caused by Atypical Strains in French Guiana, 2002-2017. ( 29957729 )
2018

Variations for Toxoplasmosis

Expression for Toxoplasmosis

Search GEO for disease gene expression data for Toxoplasmosis.

Pathways for Toxoplasmosis

Pathways related to Toxoplasmosis according to GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.11 CCR5 CD40 CD40LG CD79A HLA-DQA1 HLA-DQB1
2
Show member pathways
13.77 CCR5 CD40 CD40LG IFNG IL10 IL1B
3
Show member pathways
13.57 CCR5 CD40 CD40LG IL10 IL1B IL4
4
Show member pathways
13.54 CD40 CD40LG CD79A HLA-DQA1 HLA-DQB1 MYD88
5
Show member pathways
13.51 CCR5 CD40 CD40LG HLA-DQA1 HLA-DQB1 IFNG
6
Show member pathways
13.4 CCR5 CD40 CD40LG IL10 IL1B IL4
7
Show member pathways
13.33 CD40 CD79A HLA-DQA1 HLA-DQB1 IFNG IL1B
8
Show member pathways
13.31 CD40 IFNG IL10 IL1B IL6 MYD88
9
Show member pathways
13.06 CCR5 IL1B IL6 MYD88 TLR2 TLR4
10
Show member pathways
13.04 CD40 CD40LG HLA-DQA1 HLA-DQB1 IFNG IL10
11
Show member pathways
12.88 CD40 CD40LG IL1B IL6 MYD88 TLR2
12
Show member pathways
12.86 IFNG IL1B IL6 MYD88 TLR4 TNF
13
Show member pathways
12.8 CD40 CD40LG IL1B MYD88 TLR2 TLR4
14
Show member pathways
12.79 CCR5 CD40 CD40LG IFNG IL1B TNF
15
Show member pathways
12.79 CD40 CD40LG CD79A HLA-DQA1 HLA-DQB1 IFNG
16
Show member pathways
12.69 HLA-DQA1 HLA-DQB1 IFNG IL10 IL1B IL4
17
Show member pathways
12.68 IFNG IL10 IL1B IL6 TNF
18
Show member pathways
12.65 HLA-DQA1 HLA-DQB1 IFNG IL1B IL4 IL6
19
Show member pathways
12.62 CCR5 CD40LG IFNG IL10 IL1B IL4
20
Show member pathways
12.51 DHFR IFNG IL1B IL4 IL6 TNF
21
Show member pathways
12.51 IFNG IL1B IL4 IL6 TLR2 TNF
22 12.51 CD40LG CD79A IFNG IL10 IL1B IL4
23
Show member pathways
12.5 CCR5 IFNG IL10 IL4 IL6
24
Show member pathways
12.48 IFNG IL1B IL6 MYD88 TLR4 TNF
25 12.47 CD40 HLA-DQA1 HLA-DQB1 IL6 TNF
26
Show member pathways
12.45 CD40 CD40LG HLA-DQA1 HLA-DQB1
27
Show member pathways
12.45 IL6 MYD88 TLR2 TLR4 TLR9 TNF
28
Show member pathways
12.4 IFNG IL10 IL1B IL4 IL6 TNF
29
Show member pathways
12.39 IL10 IL1B IL6 MYD88 TLR9 TNF
30 12.37 IFNG IL6 TLR2 TLR4 TLR9 TNF
31
Show member pathways
12.36 IL1B IL6 MYD88 TLR2 TNF
32
Show member pathways
12.32 CCR5 IL1B MYD88 TLR2 TLR4 TLR9
33
Show member pathways
12.3 IFNG IL1B TLR4 TNF
34
Show member pathways
12.27 IFNG IL1B IL4 IL6 MYD88 TLR2
35 12.26 IL10 IL1B IL6 TNF
36
Show member pathways
12.24 CCR5 CD40 CD40LG HLA-DQA1 HLA-DQB1 IFNG
37 12.23 HLA-DQA1 HLA-DQB1 TLR2 TLR4
38 12.22 IFNG IL1B IL4 IL6 TLR4 TNF
39 12.21 CD40 CD40LG HLA-DQA1 HLA-DQB1
40
Show member pathways
12.21 IFNG IL10 IL1B IL6 TLR2 TLR4
41 12.2 CD79A IFNG IL10 IL4 IL6 TNF
42
Show member pathways
12.18 CD40 IFNG IL1B IL4 IL6 TLR2
43
Show member pathways
12.16 IFNG IL10 IL1B IL4 IL6
44 12.16 IL10 IL1B IL4 IL6 TNF
45
Show member pathways
12.13 IL1B TLR2 TLR4 TLR9
46 12.12 HLA-DQA1 HLA-DQB1 IL1B IL4 IL6 TNF
47 12.11 CD40 CD40LG IL1B MYD88 TLR4 TNF
48
Show member pathways
12.08 CCR5 IFNG IL1B IL4
49 12.06 IFNG IL10 IL1B IL6 TLR2 TLR4
50 12.03 IFNG IL1B IL6 MYD88 TLR4

GO Terms for Toxoplasmosis

Cellular components related to Toxoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.97 CD40 CD40LG IFNG IL10 IL1B IL4
2 extracellular region GO:0005576 9.97 CD40 CD40LG IFNG IL10 IL1B IL4
3 integral component of plasma membrane GO:0005887 9.76 CCR5 CD40 CD40LG HLA-DQA1 RHD TLR2
4 cell surface GO:0009986 9.73 CCR5 CD40 CD40LG TLR2 TLR4 TNF
5 endosome membrane GO:0010008 9.35 HLA-DQA1 HLA-DQB1 MYD88 TLR4 TLR9
6 external side of plasma membrane GO:0009897 9.1 CCR5 CD40 CD40LG CD79A TLR4 TNF

Biological processes related to Toxoplasmosis according to GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.99 CD40 IFNG IL4 IL6
2 regulation of inflammatory response GO:0050727 9.99 MYD88 NLRP1 TLR4 TNF
3 positive regulation of T cell proliferation GO:0042102 9.97 CD40LG IL1B IL4 IL6
4 positive regulation of tumor necrosis factor production GO:0032760 9.96 MYD88 TLR2 TLR4 TLR9
5 positive regulation of JNK cascade GO:0046330 9.96 IL1B MYD88 TLR4 TLR9 TNF
6 defense response to Gram-negative bacterium GO:0050829 9.95 IL6 TLR4 TLR9
7 interferon-gamma-mediated signaling pathway GO:0060333 9.94 HLA-DQA1 HLA-DQB1 IFNG
8 tumor necrosis factor-mediated signaling pathway GO:0033209 9.94 CD40 CD40LG TNF
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.94 IFNG IL1B TLR4 TNF
10 regulation of insulin secretion GO:0050796 9.93 IFNG IL1B TNF
11 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.93 TLR4 TLR9 TNF
12 humoral immune response GO:0006959 9.92 IFNG IL6 TNF
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.92 IL6 MYD88 TNF
14 positive regulation of B cell proliferation GO:0030890 9.92 CD40 IL4 TLR4 TLR9
15 positive regulation of interferon-gamma production GO:0032729 9.91 IL1B TLR4 TNF
16 toll-like receptor signaling pathway GO:0002224 9.91 MYD88 TLR2 TLR4 TLR9
17 protein kinase B signaling GO:0043491 9.9 CD40 IL1B TNF
18 B cell proliferation GO:0042100 9.9 CD40 CD40LG CD79A IL10
19 B cell activation GO:0042113 9.89 CD40 CD79A IL4
20 positive regulation of interferon-beta production GO:0032728 9.89 TLR2 TLR4 TLR9
21 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.89 MYD88 TLR2 TLR4 TLR9
22 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.89 IL1B TLR2 TLR4 TLR9 TNF
23 negative regulation of neurogenesis GO:0050768 9.88 IL1B IL6 TNF
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.88 IL1B MYD88 TLR2 TLR4 TNF
25 positive regulation of glial cell proliferation GO:0060252 9.87 IL1B IL6 TNF
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.87 IFNG IL1B TNF
27 negative regulation of interleukin-6 production GO:0032715 9.87 IL10 TLR4 TLR9 TNF
28 response to glucocorticoid GO:0051384 9.86 IL10 IL6 TNF
29 negative regulation of growth of symbiont in host GO:0044130 9.86 IL10 MYD88 TNF
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.85 IL10 IL1B TNF
31 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.85 TLR2 TLR4 TLR9
32 positive regulation of interleukin-8 production GO:0032757 9.85 IL1B MYD88 TLR2 TLR4 TLR9 TNF
33 regulation of cytokine secretion GO:0050707 9.84 TLR2 TLR4 TLR9
34 I-kappaB phosphorylation GO:0007252 9.84 TLR2 TLR4 TLR9
35 positive regulation of interleukin-10 production GO:0032733 9.84 CD40LG TLR2 TLR4 TLR9
36 response to molecule of bacterial origin GO:0002237 9.83 IL10 TLR2 TLR9
37 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.83 TLR4 TLR9 TNF
38 positive regulation of chemokine biosynthetic process GO:0045080 9.81 IL1B MYD88 TNF
39 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 CD40 CD40LG IL1B IL6 MYD88 TLR2
40 positive regulation of chemokine production GO:0032722 9.8 IL6 TLR2 TLR4 TLR9 TNF
41 positive regulation of interleukin-12 production GO:0032735 9.8 CD40 CD40LG IFNG TLR2 TLR4 TLR9
42 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL6 MYD88 TLR2 TLR4 TLR9
43 positive regulation of MHC class II biosynthetic process GO:0045348 9.79 IL10 IL4 TLR4
44 positive regulation of neuroinflammatory response GO:0150078 9.78 IL1B IL6 TNF
45 negative regulation of interleukin-17 production GO:0032700 9.77 IFNG TLR4
46 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.77 IL1B TLR9
47 immune response GO:0006955 9.77 CCR5 CD40LG HLA-DQA1 HLA-DQB1 IFNG IL10
48 cellular response to lipoteichoic acid GO:0071223 9.76 TLR2 TLR4
49 positive regulation of isotype switching to IgG isotypes GO:0048304 9.76 CD40 IL4
50 negative regulation of lipid storage GO:0010888 9.76 IL6 TNF

Molecular functions related to Toxoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.37 HLA-DQA1 HLA-DQB1
2 signaling pattern recognition receptor activity GO:0008329 9.32 TLR2 TLR9
3 Toll-like receptor binding GO:0035325 9.26 MYD88 TLR2
4 cytokine activity GO:0005125 9.17 CD40LG IFNG IL10 IL1B IL4 IL6
5 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
6 interleukin-1 receptor binding GO:0005149 9.13 IL1B MYD88 TLR9

Sources for Toxoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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