MCID: TXP001
MIFTS: 66

Toxoplasmosis

Categories: Blood diseases, Fetal diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Toxoplasmosis

MalaCards integrated aliases for Toxoplasmosis:

Name: Toxoplasmosis 12 77 56 44 3 45 15 17 74
Multisystemic Disseminated Toxoplasmosis 74
Disseminated Toxoplasmosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9965
ICD9CM 36 130 130.9
MeSH 45 D014123
NCIt 51 C3418
SNOMED-CT 69 9399000
ICD10 34 B58 B58.8 B58.9

Summaries for Toxoplasmosis

MedlinePlus : 44 Toxoplasmosis is a disease caused by the parasite Toxoplasma gondii. More than 60 million people in the U.S. have the parasite. Most of them don't get sick. But the parasite causes serious problems for some people. These include people with weak immune systems and babies whose mothers become infected for the first time during pregnancy. Problems can include damage to the brain, eyes, and other organs. You can get toxoplasmosis from Waste from an infected cat Eating contaminated meat that is raw or not well cooked Using utensils or cutting boards after they've had contact with contaminated raw meat Drinking infected water Receiving an infected organ transplant or blood transfusion Most people with toxoplasmosis don't need treatment. There are drugs to treat it for pregnant women and people with weak immune systems. Centers for Disease Control and Prevention

MalaCards based summary : Toxoplasmosis, also known as multisystemic disseminated toxoplasmosis, is related to congenital toxoplasmosis and ocular toxoplasmosis, and has symptoms including fever and pruritus. An important gene associated with Toxoplasmosis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs leucovorin and Pyrimethamine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A coccidiosis that has material basis in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

CDC : 3 Toxoplasmosis is considered one of the neglected parasitic infections of the United States, a group of five parasitic diseases that have been targeted by CDC for public health action. Image: Toxoplasma gondii in mouse ascitic fluid. Smear. (Credit: DPDx)

Wikipedia : 77 Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii. Infections with toxoplasmosis usually... more...

Related Diseases for Toxoplasmosis

Diseases in the Toxoplasmosis family:

Congenital Toxoplasmosis

Diseases related to Toxoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 594)
# Related Disease Score Top Affiliating Genes
1 congenital toxoplasmosis 34.2 CD40LG CD79A HLA-DQA1 HLA-DQB1 TLR9
2 ocular toxoplasmosis 34.2 CCR5 CD40LG CD79A TLR9
3 pneumocystosis 30.7 CD40LG DHFR TNF
4 uveitis 30.5 IFNG IL10 IL4 TNF
5 rubella 30.5 CD40LG HLA-DQB1 IL10 IL4 TNF
6 cryptosporidiosis 30.3 CD40LG CD79A DHFR
7 schistosomiasis 30.3 CD40LG IFNG IL10 IL4 TNF
8 acquired immunodeficiency syndrome 30.2 CCR5 IFNG IL10 IL1B IL6 TNF
9 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 30.2 CCR5 CD40LG IFNG IL10 IL4
10 congenital cytomegalovirus 30.2 IL1B TLR2 TNF
11 hematopoietic stem cell transplantation 30.2 IFNG IL10 IL6 TNF
12 lymphadenitis 30.1 IFNG IL10 IL1B TLR4 TNF
13 neuritis 30.0 IFNG IL1B IL4 TNF
14 scleritis 30.0 IFNG IL4 TNF
15 strongyloidiasis 30.0 CD79A IFNG TGFB1
16 cryptococcosis 29.9 IFNG IL4 TLR9
17 cytomegalovirus infection 29.9 IL1B IL6 TNF
18 cytomegalovirus retinitis 29.9 CCR5 HLA-DQB1 IFNG TNF
19 ige responsiveness, atopic 29.9 IFNG IL10 IL4
20 variola major 29.8 IFNG TLR4
21 tuberculous meningitis 29.8 TGFB1 TLR2 TNF
22 campylobacteriosis 29.8 IFNG IL1B TLR4
23 guillain-barre syndrome 29.8 CD79A HLA-DQA1 HLA-DQB1 TNF
24 myasthenia gravis 29.8 IFNG IL10 IL4 TNF
25 acute disseminated encephalomyelitis 29.7 HLA-DQA1 HLA-DQB1 IL10 IL1B
26 immunodeficiency with hyper-igm, type 1 29.7 CD40 CD40LG CD79A IL4
27 post-transplant lymphoproliferative disease 29.6 IL10 IL6 TNF
28 human immunodeficiency virus type 1 29.6 CCR5 CD40 IFNG IL10 IL6 TNF
29 myocarditis 29.5 CD40 CD40LG HLA-DQB1 IL6 TNF
30 human immunodeficiency virus infectious disease 29.5 CCR5 IFNG IL10 IL6 TLR9 TNF
31 posterior uveitis 29.5 IFNG IL6 TNF
32 parasitic helminthiasis infectious disease 29.5 IL10 IL4 TLR9 TNF
33 cysticercosis 29.5 IL1B IL6 TLR4
34 meningoencephalitis 29.5 CD40LG CD79A IL6 TLR9
35 allergic hypersensitivity disease 29.5 IFNG IL10 IL4 TLR9
36 sarcoidosis 1 29.4 IFNG IL1B TNF
37 viral hepatitis 29.4 HLA-DQA1 TLR2 TLR9 TNF
38 acute respiratory distress syndrome 29.4 IL1B IL6 TNF
39 leptospirosis 29.4 IFNG IL10 IL1B IL6 TLR2 TNF
40 chikungunya 29.4 IL1B IL6 TNF
41 adult respiratory distress syndrome 29.3 IL10 IL6 TNF
42 brucellosis 29.3 CD40LG IFNG IL10 IL4 IL6 TLR4
43 pericarditis 29.3 IFNG IL1B IL6 TNF
44 end stage renal failure 29.3 IL6 TGFB1 TNF
45 glomerulonephritis 29.3 CD40LG CD79A IL1B TGFB1 TLR9
46 juvenile rheumatoid arthritis 29.3 HLA-DQA1 IL1B IL6 TNF
47 extrinsic allergic alveolitis 29.3 IL10 IL1B IL6
48 arthritis 29.3 HLA-DQB1 IFNG IL10 IL1B IL6 TGFB1
49 peritonitis 29.3 IL10 IL1B IL6 TLR2 TNF
50 coccidiosis 29.3 IFNG IL10 IL4 RHD TLR9 TNF

Graphical network of the top 20 diseases related to Toxoplasmosis:



Diseases related to Toxoplasmosis

Symptoms & Phenotypes for Toxoplasmosis

UMLS symptoms related to Toxoplasmosis:


fever, pruritus

GenomeRNAi Phenotypes related to Toxoplasmosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 CD40LG DHFR HLA-DQB1 IL10 IL1B MYD88
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 CD40LG DHFR HLA-DQB1 IL10 IL1B MYD88

MGI Mouse Phenotypes related to Toxoplasmosis:

47 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.55 ALOX12 CCR5 CD40 CD40LG CD79A DHFR
2 homeostasis/metabolism MP:0005376 10.51 ALOX12 CCR5 CD40 CD40LG CD79A DHFR
3 immune system MP:0005387 10.5 ALOX12 CCR5 CD40 CD40LG CD79A DHFR
4 cellular MP:0005384 10.46 CCR5 CD40LG CD79A DHFR HLA-DQB1 IFNG
5 cardiovascular system MP:0005385 10.4 CCR5 CD40LG DHFR HLA-DQB1 IFNG IL10
6 digestive/alimentary MP:0005381 10.35 CCR5 HLA-DQB1 IFNG IL10 IL4 IL6
7 endocrine/exocrine gland MP:0005379 10.35 CD40 CD40LG HLA-DQA1 HLA-DQB1 IFNG IL10
8 mortality/aging MP:0010768 10.35 CCR5 CD40LG DHFR HLA-DQB1 IFNG IL10
9 growth/size/body region MP:0005378 10.34 DHFR HLA-DQB1 IFNG IL10 IL1B IL4
10 integument MP:0010771 10.29 ALOX12 CD40LG DHFR IFNG IL10 IL1B
11 nervous system MP:0003631 10.28 CCR5 CD40 CD40LG CD79A HLA-DQB1 IFNG
12 liver/biliary system MP:0005370 10.27 CCR5 CD79A DHFR HLA-DQB1 IFNG IL10
13 neoplasm MP:0002006 10.17 CCR5 CD79A IFNG IL10 IL1B IL6
14 muscle MP:0005369 10.16 CCR5 DHFR HLA-DQB1 IFNG IL10 IL6
15 renal/urinary system MP:0005367 10.1 CD40 CD40LG CD79A HLA-DQB1 IFNG IL4
16 reproductive system MP:0005389 10 CCR5 CD40LG HLA-DQB1 IFNG IL10 IL4
17 no phenotypic analysis MP:0003012 9.85 CD79A IFNG IL10 IL4 MYD88 TNF
18 respiratory system MP:0005388 9.85 HLA-DQB1 IFNG IL10 IL4 IL6 MYD88
19 skeleton MP:0005390 9.73 CD40 CD40LG IFNG IL10 IL1B IL4
20 vision/eye MP:0005391 9.28 CCR5 IFNG IL10 IL4 IL6 MYD88

Drugs & Therapeutics for Toxoplasmosis

Drugs for Toxoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 133)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
2
Pyrimethamine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-14-0 4993
3
Sulfadiazine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 68-35-9 5215
4
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
5
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
6
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
7
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
8
Nevirapine Approved Phase 4 129618-40-2 4463
9
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 1 155213-67-5 392622
10
Tenofovir Approved, Experimental, Investigational Phase 4 147127-20-6 464205
11
Spiramycin Approved Phase 4,Phase 3 24916-50-5
12
Levoleucovorin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68538-85-2
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
14
Calcium Approved, Nutraceutical Phase 4,Phase 2,Phase 1,Not Applicable 7440-70-2 271
15 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Vitamin B9 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Folate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Antimalarials Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24
protease inhibitors Phase 4,Phase 3,Phase 1
25 HIV Protease Inhibitors Phase 4,Phase 3,Phase 1
26 Hormones Phase 4,Phase 3,Phase 1,Phase 2
27 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Central Nervous System Depressants Phase 4
29 Neurotransmitter Agents Phase 4
30 Antimanic Agents Phase 4
31 Psychotropic Drugs Phase 4
32 Tranquilizing Agents Phase 4
33 Anticonvulsants Phase 4
34 GABA Agents Phase 4
35 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3
36 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
37 Antiviral Agents Phase 4,Phase 3,Phase 1
38 Atazanavir Sulfate Phase 4,Phase 3,Phase 1
39 Reverse Transcriptase Inhibitors Phase 4,Phase 3,Phase 1
40 Anti-HIV Agents Phase 4,Phase 3,Phase 1
41 Anti-Retroviral Agents Phase 4,Phase 3,Phase 1
42 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
43 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
44 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 1
45 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 1
46 Trace Elements Phase 4,Phase 3,Phase 1
47 Antidotes Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Bone Density Conservation Agents Phase 4,Phase 1
49 Nutrients Phase 4,Phase 3,Phase 1
50 Vitamins Phase 4,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Pilot Trial of Valproate as Adjunctive Treatment for Toxoplasma Gondii Infection in Early Course Schizophrenia Completed NCT02011750 Phase 4 Sodium Valproate treatment;Placebo
2 Treatment of Cerebral Toxoplasmosis in HIV/AIDS Completed NCT00367081 Phase 4 TMX-SMX (Bactrim(R));Pyrimethamine plus Sulfadiazine plus leucoverin
3 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
4 Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis Recruiting NCT00004317 Phase 4 Leucovorin calcium;Pyrimethamine;Spiramycin;Sulfadiazine
5 Assessment of Two Therapeutic Strategies in the Treatment of Children With Congenital Toxoplasmosis Unknown status NCT01202500 Phase 3
6 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3 pyrimethamine-sulfadiazine + prednisolone;Clindamycin+Dexamethasone
7 Prevention of Congenital Toxoplasmosis With Pyrimethamine + Sulfadiazine Versus Spiramycine During Pregnancy Completed NCT01189448 Phase 3 Pyrimethamine/Sulfadiazine;Spiramycine
8 Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis Completed NCT01449877 Phase 3 Trimethoprim-Sulfamethoxazole
9 Effect of Specific Anti-Toxoplasmatic Add-on Medication in Toxoplasma Gondii Seropositive Individuals With Schizophrenia or Major Depression Completed NCT00300404 Phase 3 daraprim;pyrimethamine;folinic acid
10 A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected Patients Completed NCT00000991 Phase 3 Pentamidine isethionate;Sulfamethoxazole-Trimethoprim;Dapsone;Zidovudine
11 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3 Clotrimazole;Fluconazole
12 A Randomized Study of Daily and Intermittent Prophylactic Regimens for the Prevention of Disseminated Mycobacterium Avium Complex (MAC) and Fungal Infections in HIV-Infected Patients Completed NCT00002122 Phase 3 Azithromycin;Rifabutin;Fluconazole
13 PRINCE: Study of Atazanavir (ATV)/Ritonavir (RTV) Completed NCT01099579 Phase 3 Atazanavir powder;Ritonavir oral solution;Atazanavir capsules;Ritonavir capsules
14 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin
15 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
16 Primary Prophylaxis of Cerebral Toxoplasmosis in HIV-Infected Patients Completed NCT00000643 Phase 2 Pyrimethamine;Leucovorin calcium
17 Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis Completed NCT00000794 Phase 2 Sulfadiazine;Clarithromycin;Atovaquone;Pyrimethamine;Leucovorin calcium
18 A Open-Label Study Of CP-690,550 As Long-Term Therapy (48 Weeks) In Subjects With Crohn's Disease Completed NCT01470599 Phase 2 CP-690,550;CP-690,550
19 High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals Completed NCT00885703 Phase 1, Phase 2 Fluconazole;Amphotericin B
20 Expanded Cord Blood in Patients in Need of an Allogeneic Stem Cell Transplant Completed NCT02668315 Phase 1, Phase 2
21 UM171 Expanded Cord Blood In Patients With High-Risk Acute Leukemia/Myelodysplasia Not yet recruiting NCT03913026 Phase 2
22 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
23 Phase I Study of Pyrimethamine in Healthy Japanese and Caucasian Subjects Completed NCT03258762 Phase 1 Pyrimethamine;Calcium folinate
24 A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive Patients Completed NCT00000973 Phase 1 Pyrimethamine;Leucovorin calcium;Zidovudine
25 Antiretroviral Drug Interaction Study in Volunteers With HIV Completed NCT01479361 Phase 1 Atovaquone 750 mg twice daily;Atovaquone 1500 mg twice daily
26 A Study of Azithromycin Plus Pyrimethamine in the Treatment of a Brain Infection in Patients With AIDS Completed NCT00000966 Phase 1 Azithromycin;Pyrimethamine;Leucovorin calcium
27 A Phase I Study of Autologous, Activated CD8(+) Lymphocytes Expanded In Vitro and Infused With or Without Recombinant Interleukin-2 to Patients With AIDS or Severe ARC Completed NCT00000680 Phase 1 Zidovudine;Aldesleukin
28 A Phase I Study of Pyrimethamine in Patients With GM2 Gangliosidosis Withdrawn NCT00679744 Phase 1 Pyrimethamine
29 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Not Applicable Anti-toxoplasmosis treatment;Anti-inflammatory treatments
30 Immunoblotting and Goldmann-Witmer Coefficient for Ocular Toxoplasmosis Completed NCT03948750
31 Cerebral Toxoplasmosis and AIDS Completed NCT00803621
32 A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii Infection Completed NCT00000666 Not Applicable Pyrimethamine
33 A Pilot Study of 566C80 for the Salvage Treatment of Toxoplasmic Encephalitis in Patients Infected With the Human Immunodeficiency Virus (HIV) Who Have Failed or Are Intolerant of Pyrimethamine-Sulfadiazine Completed NCT00001994 Not Applicable Atovaquone
34 A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS Completed NCT00000674 Not Applicable Pyrimethamine;Leucovorin calcium;Clindamycin
35 Toxoplasmic Encephalitis in Patients With AIDS. Treatment and Prevention of Relapse Completed NCT00002064 Not Applicable Pyrimethamine;Clindamycin
36 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697
37 Drug Exposure Registry for GSK2248761, an Investigational NNRTI Completed NCT01458132 Not Applicable GSK2248761
38 Evaluation of Brain Lesions in HIV-infected Patients for Diagnosis of Primary Central Nervous System Lymphoma Completed NCT00226304
39 Expanded Noninvasive Genomic Medical Assessment: The Enigma Study Completed NCT02787486
40 Uveitis Gene-Expression Profiling Completed NCT00874471
41 HIV Cohort Study At Johns Hopkins University, University of North Carolina at Chapel Hill and Vanderbilt University Completed NCT01339416
42 Kaiser Permanente HIV Cohort Study Completed NCT01339403
43 New Diagnostic Approach for Congenital Toxoplasmosis Recruiting NCT03385499 Not Applicable
44 Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis Recruiting NCT02863588 Not Applicable
45 Lyon Cohort of Maternal and Congenital Toxoplasma Infections Recruiting NCT02936921
46 Apheresis of Patients With Immunodeficiency Recruiting NCT01212055
47 Genetics of Uveitis Recruiting NCT02357238
48 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
49 Latent Toxoplasmosis in Females With Borderline Personality Disorder Not yet recruiting NCT03932656 Psychopharmaceuticals
50 Surveillance of Zika-related Microcephaly in Sub-Saharan Africa and Asia Not yet recruiting NCT03922594

Search NIH Clinical Center for Toxoplasmosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: toxoplasmosis

Genetic Tests for Toxoplasmosis

Anatomical Context for Toxoplasmosis

MalaCards organs/tissues related to Toxoplasmosis:

42
Eye, Testes, Brain, T Cells, Lymph Node, B Cells, Bone Marrow

Publications for Toxoplasmosis

Articles related to Toxoplasmosis:

(show top 50) (show all 3540)
# Title Authors Year
1
Latent toxoplasmosis aggravates anxiety- and depressive-like behaviour and suggest a role of gene-environment interactions in the behavioural response to the parasite. ( 30768994 )
2019
2
Seroprevalence of Toxoplasma gondii Infection Among Β-Thalassemia Major Pediatric Population: Implications for Transfusion Transmissible Toxoplasmosis. ( 29762364 )
2019
3
Seropositivities against brucellosis, coxiellosis, and toxoplasmosis and associated factors in pregnant women with adverse pregnancy outcomes: A cross-sectional study. ( 31071166 )
2019
4
Prevalence and Risk Factors of Brucellosis, Toxoplasmosis, and Neosporosis Among Yanbian Yellow Cattle in Jilin Province, China. ( 30328792 )
2019
5
Tissue and blood protozoa including toxoplasmosis, Chagas disease, leishmaniasis, Babesia, Acanthamoeba, Balamuthia, and Naegleria in solid organ transplant recipients- Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. ( 30900295 )
2019
6
Optical Coherence Tomography Angiography of Retinal-Choroidal Anastomosis in Toxoplasmosis Chorioretinitis. ( 30869760 )
2019
7
Detection of Toxoplasma gondii B1 gene in placenta does not prove congenital toxoplasmosis. ( 30103311 )
2019
8
Maternal and Congenital Toxoplasmosis: Diagnosis and Treatment Recommendations of a French Multidisciplinary Working Group. ( 30781652 )
2019
9
Congenital toxoplasmosis and proposal of a new classification for the likelihood of primary maternal infection: analysis of 375 cases in Southeast Italy. ( 30835583 )
2019
10
Congenital toxoplasmosis in the United States: clinical and serologic findings in infants born to mothers treated during pregnancy. ( 30838974 )
2019
11
Disseminated and Congenital Toxoplasmosis in a Mother and Child With Activated PI3-Kinase δ Syndrome Type 2 (APDS2): Case Report and a Literature Review of Toxoplasma Infections in Primary Immunodeficiencies. ( 30891027 )
2019
12
Congenital toxoplasmosis: the challenge of early diagnosis of a complex and neglected disease. ( 30994797 )
2019
13
Congenital toxoplasmosis among Iranian neonatal population: Two systematic reviews and meta-analyses. ( 31096746 )
2019
14
Concurrent cerebral toxoplasmosis and cytomegalovirus retinitis in a patient with human immunodeficiency virus. ( 30851795 )
2019
15
Toxoplasmosis and secondary Guillain-Barré associated with ruxolitinib as graft-versus-host disease treatment. ( 30207078 )
2019
16
Cerebral toxoplasmosis after allogeneic hematopoietic stem cell transplantation diagnosed by megagenomic analysis. ( 30741826 )
2019
17
Disseminated toxoplasmosis with atypical symptoms which developed with exacerbation of systemic lupus erythematosus. ( 30486727 )
2019
18
Focal Intramedullary Spinal Cord Lesion in HIV/AIDs: Toxoplasmosis vs. Lymphoma. ( 30981796 )
2019
19
Intraocular toxoplasmosis mimicking vitreous lymphoma. ( 30765498 )
2019
20
Serological prevalence of toxoplasmosis and neosporosis in dogs diagnosed with suspected meningoencephalitis in the UK. ( 30371939 )
2019
21
Cytokine Profile in Sweet's Syndrome under the Treatment of Pulmonary Toxoplasmosis Complicated with Myelodysplastic Syndrome. ( 30918190 )
2019
22
Relationship between toxoplasmosis and obsessive compulsive disorder: A systematic review and meta-analysis. ( 30969961 )
2019
23
Seroprevalence and Manifestations of Ocular Toxoplasmosis in Patients with Schizophrenia. ( 29283732 )
2019
24
Sero-molecular detection, multi-locus genotyping, and clinical manifestations of ocular toxoplasmosis in patients in northwest Iran. ( 30624725 )
2019
25
Effectiveness of Treatments for Ocular Toxoplasmosis. ( 30806556 )
2019
26
Type I ROP16 regulates retinal inflammatory responses during ocular toxoplasmosis. ( 30901349 )
2019
27
Immune Mediator Profile in Aqueous Humor Differs in Patients with Primary Acquired Ocular Toxoplasmosis and Recurrent Acute Ocular Toxoplasmosis. ( 30906227 )
2019
28
Ocular toxoplasmosis related macular traction: A case report and review of the literature. ( 30930669 )
2019
29
Optic nerve involvement in ocular toxoplasmosis: 12 year data from a tertiary referral center in Turkey. ( 30970124 )
2019
30
Evaluation of RE and B1 Genes as Targets for Detection of Toxoplasma gondii by Nested PCR in Blood Samples of Patients with Ocular Toxoplasmosis. ( 31020496 )
2019
31
Monitoring of visual field over 6 months after active ocular toxoplasmosis. ( 31037491 )
2019
32
Ultrasonographic characteristics of active ocular toxoplasmosis. ( 31038555 )
2019
33
When biology supports clinical diagnosis: review of techniques to diagnose ocular toxoplasmosis. ( 31088793 )
2019
34
Parasitic Infections of the Stem Cell Transplant Recipient and the Hematologic Malignancy Patient, Including Toxoplasmosis and Strongyloidiasis. ( 31005139 )
2019
35
Pediatric Amazonian Toxoplasmosis Caused by Atypical Strains in French Guiana, 2002-2017. ( 29957729 )
2019
36
Mortality Due to Toxoplasmosis in Suburban Eastern Fox Squirrels ( Sciurus niger) in Michigan, USA. ( 30096029 )
2019
37
Screening of toxoplasmosis in cancer patients: a concern. ( 30270766 )
2019
38
Congenital human toxoplasmosis caused by non-clonal Toxoplasma gondii genotypes in Argentina. ( 30304711 )
2019
39
Outbreak of toxoplasmosis in four squirrel monkeys (Saimiri sciureus) in Japan. ( 30347233 )
2019
40
Serological diagnosis of Toxoplasmosis disease using a fluorescent immunosensor with chitosan-ZnO-nanoparticles. ( 30393087 )
2019
41
Interpretation of very low avidity indices acquired with the Liaison XL Toxo IgG avidity assay in dating toxoplasmosis infection. ( 30411219 )
2019
42
Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis. ( 30423128 )
2019
43
Molecular diagnosis of toxoplasmosis at the onset of symptomatic primary infection: A straightforward alternative to serological examinations. ( 30529368 )
2019
44
Toxoplasmosis, but not borreliosis, is associated with psychiatric disorders and symptoms - false negative findings? ( 30612843 )
2019
45
Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. ( 30624926 )
2019
46
Toxoplasmosis: The Heart of the Diagnosis. ( 30631794 )
2019
47
High burden and low awareness of toxoplasmosis in the United States. ( 30638425 )
2019
48
Disruption of P2X7 Signaling Increases Susceptibility to Cerebral Toxoplasmosis. ( 30653952 )
2019
49
Vaccination with recombinant adenoviruses expressing Toxoplasma gondii MIC3, ROP9, and SAG2 provide protective immunity against acute toxoplasmosis in mice. ( 30670302 )
2019
50
Erratum: Prevalence and risk factors of toxoplasmosis among adults in a small Brazilian city. ( 30698199 )
2019

Variations for Toxoplasmosis

Expression for Toxoplasmosis

Search GEO for disease gene expression data for Toxoplasmosis.

Pathways for Toxoplasmosis

Pathways related to Toxoplasmosis according to GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.15 CCR5 CD40 CD40LG CD79A HLA-DQA1 HLA-DQB1
2
Show member pathways
13.8 CCR5 CD40 CD40LG IFNG IL10 IL1B
3
Show member pathways
13.56 CCR5 CD40 CD40LG IL10 IL1B IL4
4
Show member pathways
13.54 CD40 CD40LG CD79A HLA-DQA1 HLA-DQB1 MYD88
5
Show member pathways
13.5 CCR5 CD40 CD40LG HLA-DQA1 HLA-DQB1 IFNG
6
Show member pathways
13.44 CCR5 CD40 CD40LG IL10 IL1B IL4
7
Show member pathways
13.37 CD40 CD79A HLA-DQA1 HLA-DQB1 IFNG IL1B
8
Show member pathways
13.26 CD40 IFNG IL10 IL1B IL6 MYD88
9
Show member pathways
13.11 CCR5 IL1B IL6 MYD88 TGFB1 TLR2
10
Show member pathways
13.05 CD40 CD40LG HLA-DQA1 HLA-DQB1 IFNG IL10
11
Show member pathways
12.88 IFNG IL1B IL6 MYD88 TLR4 TNF
12
Show member pathways
12.88 CD40 CD40LG IL1B IL6 MYD88 TGFB1
13
Show member pathways
12.83 CD40 CD40LG CD79A HLA-DQA1 HLA-DQB1 IFNG
14
Show member pathways
12.81 CD40 CD40LG IL1B MYD88 TLR2 TLR4
15
Show member pathways
12.8 CCR5 CD40 CD40LG IFNG IL1B TNF
16
Show member pathways
12.74 CCR5 CD40LG IFNG IL10 IL1B IL4
17 12.72 CD40LG CD79A IFNG IL10 IL1B IL4
18
Show member pathways
12.68 IFNG IL10 IL1B IL6 TNF
19
Show member pathways
12.68 HLA-DQA1 HLA-DQB1 IFNG IL10 IL1B IL4
20 12.53 CD40 HLA-DQA1 HLA-DQB1 IL6 TGFB1 TNF
21
Show member pathways
12.51 CCR5 IFNG IL10 IL4 IL6
22
Show member pathways
12.51 DHFR IFNG IL1B IL4 IL6 TNF
23
Show member pathways
12.51 IFNG IL1B IL4 IL6 TLR2 TNF
24
Show member pathways
12.48 IFNG IL1B IL6 MYD88 TLR4 TNF
25
Show member pathways
12.45 CD40 CD40LG HLA-DQA1 HLA-DQB1
26
Show member pathways
12.45 IL6 MYD88 TLR2 TLR4 TLR9 TNF
27
Show member pathways
12.44 IFNG IL10 IL1B IL4 IL6 TGFB1
28
Show member pathways
12.4 IL10 IL1B IL6 MYD88 TLR9 TNF
29 12.4 IFNG IL6 TGFB1 TLR2 TLR4 TLR9
30 12.37 TGFB1 TLR2 TLR4 TNF
31
Show member pathways
12.37 IL1B IL6 MYD88 TLR2 TNF
32
Show member pathways
12.37 CCR5 CD40 CD40LG HLA-DQA1 HLA-DQB1 IFNG
33
Show member pathways
12.35 IFNG IL1B IL4 IL6 MYD88 TLR2
34
Show member pathways
12.33 CCR5 IL1B MYD88 TLR2 TLR4 TLR9
35
Show member pathways
12.3 IFNG IL1B TLR4 TNF
36 12.27 IL10 IL1B IL6 TNF
37 12.24 HLA-DQA1 HLA-DQB1 TLR2 TLR4
38 12.23 IFNG IL1B IL4 IL6 TGFB1 TLR4
39
Show member pathways
12.23 CD40 IFNG IL1B IL4 IL6 TLR2
40 12.22 CD40 CD40LG HLA-DQA1 HLA-DQB1
41
Show member pathways
12.22 IFNG IL10 IL1B IL4 IL6 TGFB1
42 12.21 CD79A IFNG IL10 IL4 IL6 TNF
43 12.2 IL10 IL1B IL4 IL6 TGFB1 TNF
44 12.16 IFNG IL1B TGFB1 TNF
45
Show member pathways
12.14 IL1B TLR2 TLR4 TLR9
46
Show member pathways
12.14 IFNG IL10 IL1B IL6 TGFB1 TLR2
47 12.13 CD40 CD40LG IL1B MYD88 TLR4 TNF
48 12.12 HLA-DQA1 HLA-DQB1 IL1B IL4 IL6 TNF
49
Show member pathways
12.09 CCR5 IFNG IL1B IL4
50 12.08 IFNG IL10 IL1B IL6 TGFB1 TLR2

GO Terms for Toxoplasmosis

Cellular components related to Toxoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.97 CCR5 CD40 CD40LG HLA-DQA1 RHD TLR2
2 extracellular space GO:0005615 9.97 CD40 CD40LG IFNG IL10 IL1B IL4
3 extracellular region GO:0005576 9.96 CD40 CD40LG IFNG IL10 IL1B IL4
4 endosome membrane GO:0010008 9.55 HLA-DQA1 HLA-DQB1 MYD88 TLR4 TLR9
5 cell surface GO:0009986 9.5 CCR5 CD40 CD40LG TGFB1 TLR2 TLR4
6 external side of plasma membrane GO:0009897 9.1 CCR5 CD40 CD40LG CD79A TLR4 TNF

Biological processes related to Toxoplasmosis according to GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of JNK cascade GO:0046330 9.98 IL1B MYD88 TLR4 TLR9 TNF
2 positive regulation of T cell proliferation GO:0042102 9.97 CD40LG IL1B IL4 IL6
3 cellular response to mechanical stimulus GO:0071260 9.97 CD40 IL1B MYD88 TGFB1 TLR4
4 immune response GO:0006955 9.97 CCR5 CD40LG HLA-DQA1 HLA-DQB1 IFNG IL10
5 defense response to Gram-negative bacterium GO:0050829 9.96 IL6 TLR4 TLR9
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.96 IL6 TGFB1 TNF
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 TGFB1 TLR4 TNF
8 positive regulation of tumor necrosis factor production GO:0032760 9.96 MYD88 TLR2 TLR4 TLR9
9 cellular response to organic cyclic compound GO:0071407 9.95 IL1B TGFB1 TNF
10 interferon-gamma-mediated signaling pathway GO:0060333 9.95 HLA-DQA1 HLA-DQB1 IFNG
11 regulation of inflammatory response GO:0050727 9.95 MYD88 TLR4 TNF
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.95 IFNG IL1B TLR4 TNF
13 tumor necrosis factor-mediated signaling pathway GO:0033209 9.94 CD40 CD40LG TNF
14 regulation of insulin secretion GO:0050796 9.94 IFNG IL1B TNF
15 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.94 TLR4 TLR9 TNF
16 positive regulation of MAP kinase activity GO:0043406 9.94 CD40 TGFB1 TNF
17 positive regulation of B cell proliferation GO:0030890 9.94 CD40 IL4 TLR4 TLR9
18 humoral immune response GO:0006959 9.93 IFNG IL6 TNF
19 positive regulation of smooth muscle cell proliferation GO:0048661 9.93 IL6 MYD88 TNF
20 negative regulation of fat cell differentiation GO:0045599 9.93 IL6 TGFB1 TNF
21 protein kinase B signaling GO:0043491 9.93 CD40 IL1B TGFB1 TNF
22 extrinsic apoptotic signaling pathway GO:0097191 9.92 IFNG TGFB1 TNF
23 positive regulation of interferon-gamma production GO:0032729 9.92 IL1B TLR4 TNF
24 toll-like receptor signaling pathway GO:0002224 9.92 MYD88 TLR2 TLR4 TLR9
25 B cell proliferation GO:0042100 9.91 CD40 CD40LG CD79A IL10
26 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.91 MYD88 TLR2 TLR4 TLR9
27 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 IL1B TLR2 TLR4 TLR9 TNF
28 negative regulation of mitotic cell cycle GO:0045930 9.9 IL10 TGFB1 TNF
29 B cell activation GO:0042113 9.9 CD40 CD79A IL4
30 positive regulation of interferon-beta production GO:0032728 9.9 TLR2 TLR4 TLR9
31 negative regulation of neurogenesis GO:0050768 9.89 IL1B IL6 TNF
32 positive regulation of protein complex assembly GO:0031334 9.89 IFNG TGFB1 TNF
33 negative regulation of interleukin-6 production GO:0032715 9.89 IL10 TLR4 TLR9 TNF
34 positive regulation of glial cell proliferation GO:0060252 9.88 IL1B IL6 TNF
35 lipopolysaccharide-mediated signaling pathway GO:0031663 9.88 IL1B MYD88 TGFB1 TLR2 TLR4 TNF
36 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.87 IFNG IL1B TNF
37 response to glucocorticoid GO:0051384 9.87 IL10 IL6 TNF
38 negative regulation of growth of symbiont in host GO:0044130 9.86 IL10 MYD88 TNF
39 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.86 IL10 IL1B TNF
40 positive regulation of interleukin-10 production GO:0032733 9.86 CD40LG TLR2 TLR4 TLR9
41 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.85 TLR2 TLR4 TLR9
42 regulation of cytokine secretion GO:0050707 9.85 TLR2 TLR4 TLR9
43 positive regulation of chemokine production GO:0032722 9.85 IL6 TLR2 TLR4 TLR9 TNF
44 positive regulation of interleukin-8 production GO:0032757 9.85 IL1B MYD88 TLR2 TLR4 TLR9 TNF
45 I-kappaB phosphorylation GO:0007252 9.84 TLR2 TLR4 TLR9
46 negative regulation of interleukin-17 production GO:0032700 9.84 IFNG TGFB1 TLR4
47 response to molecule of bacterial origin GO:0002237 9.83 IL10 TLR2 TLR9
48 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.83 TLR4 TLR9 TNF
49 positive regulation of chemokine biosynthetic process GO:0045080 9.82 IL1B MYD88 TNF
50 positive regulation of MHC class II biosynthetic process GO:0045348 9.81 IL10 IL4 TLR4

Molecular functions related to Toxoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 IL10 IL4 IL6 TGFB1
2 MHC class II receptor activity GO:0032395 9.4 HLA-DQA1 HLA-DQB1
3 signaling pattern recognition receptor activity GO:0008329 9.37 TLR2 TLR9
4 Toll-like receptor binding GO:0035325 9.32 MYD88 TLR2
5 cytokine activity GO:0005125 9.23 CD40LG IFNG IL10 IL1B IL4 IL6
6 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
7 interleukin-1 receptor binding GO:0005149 9.13 IL1B MYD88 TLR9

Sources for Toxoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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