MCID: TRC014
MIFTS: 30

Trachea Adenoid Cystic Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Trachea Adenoid Cystic Carcinoma

MalaCards integrated aliases for Trachea Adenoid Cystic Carcinoma:

Name: Trachea Adenoid Cystic Carcinoma 12 15
Tracheal Adenoid Cystic Carcinoma 12 17
Adenoid Cystic Carcinoma of Trachea 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4875
NCIt 49 C6051
UMLS 71 C0345945

Summaries for Trachea Adenoid Cystic Carcinoma

MalaCards based summary : Trachea Adenoid Cystic Carcinoma, also known as tracheal adenoid cystic carcinoma, is related to adenoid cystic carcinoma and tracheal cancer, and has symptoms including pain An important gene associated with Trachea Adenoid Cystic Carcinoma is ACCS (1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive)), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. Affiliated tissues include trachea, thyroid and lung, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Related Diseases for Trachea Adenoid Cystic Carcinoma

Diseases related to Trachea Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 55, show less)
# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 30.5 MYB KIT ACCS
2 tracheal cancer 10.3
3 bronchitis 10.3
4 dysphagia 10.3
5 thyroid tumor 10.3
6 trachea leiomyoma 10.1
7 thyroid carcinoma 10.1
8 lung adenoid cystic carcinoma 10.1 KIT ACCS
9 asthma 10.1
10 squamous cell carcinoma 10.1
11 tracheal disease 10.1
12 tracheal stenosis 10.1
13 bronchiectasis 10.1
14 syncope 10.1
15 virus-associated trichodysplasia spinulosa 10.1
16 rare tumor 10.1
17 adenoid basal cell carcinoma 10.1 KIT ACCS
18 retroperitoneal sarcoma 10.1 KIT ACCS
19 cribriform carcinoma 10.1 KIT ACCS
20 cervical adenoid cystic carcinoma 10.1 MYB KIT
21 polymorphous low-grade adenocarcinoma 10.1 MYB KIT
22 tonsil cancer 10.0 KIT ACCS
23 oropharynx cancer 10.0 KIT ACCS
24 salivary gland disease 10.0 KIT ACCS
25 thymus clear cell carcinoma 9.9 NKX2-1 KIT
26 mediastinal cancer 9.9 NKX2-1 KIT
27 uterus leiomyosarcoma 9.9 NKX2-1 KIT
28 ovarian germ cell cancer 9.9 NKX2-1 KIT
29 perivascular epithelioid cell tumor 9.9 NKX2-1 KIT
30 pleomorphic carcinoma 9.9 NKX2-1 KIT
31 cystic teratoma 9.9 NKX2-1 KIT
32 teratoma 9.9 NKX2-1 KIT
33 precursor t-cell acute lymphoblastic leukemia 9.9 NOTCH3 MYB
34 large cell neuroendocrine carcinoma 9.9 NKX2-1 KIT
35 neuroendocrine carcinoma 9.9 NKX2-1 KIT
36 thymus cancer 9.9 NKX2-1 KIT
37 thymic carcinoma 9.9 NKX2-1 KIT
38 cavernous hemangioma 9.8 NKX2-1 KIT
39 mucinous adenocarcinoma 9.8 NKX2-1 KIT
40 adenosquamous carcinoma 9.8 NKX2-1 KIT
41 small cell carcinoma 9.8 NKX2-1 KIT
42 merkel cell carcinoma 9.8 NKX2-1 KIT
43 spondylocostal dysostosis 3, autosomal recessive 9.8 NOTCH3 JAG1
44 ossifying fibroma 9.8 NOTCH3 JAG1
45 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 9.7 NOTCH3 JAG1
46 large cell carcinoma 9.7 NKX2-1 KIT
47 alagille syndrome 1 9.7 NOTCH3 JAG1
48 oncocytoma 9.7 NKX2-1 KIT
49 adams-oliver syndrome 9.7 NOTCH3 JAG1
50 cutaneous adenocystic carcinoma 9.6 NKX2-1 KIT ACCS
51 small cell cancer of the lung 9.6 NKX2-1 KIT
52 salivary gland carcinoma 9.6 KIT ACCS
53 colorectal adenocarcinoma 9.5 NKX2-1 KIT
54 acute t cell leukemia 9.5 NOTCH3 JAG1
55 hemangioma 8.9 NOTCH3 NKX2-1 KIT JAG1

Graphical network of the top 20 diseases related to Trachea Adenoid Cystic Carcinoma:



Diseases related to Trachea Adenoid Cystic Carcinoma

Symptoms & Phenotypes for Trachea Adenoid Cystic Carcinoma

UMLS symptoms related to Trachea Adenoid Cystic Carcinoma:


pain

MGI Mouse Phenotypes related to Trachea Adenoid Cystic Carcinoma:

45 (showing 4, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 JAG1 KIT MYB NKX2-1 NOTCH3
2 endocrine/exocrine gland MP:0005379 9.55 JAG1 KIT MYB NKX2-1 NOTCH3
3 no phenotypic analysis MP:0003012 9.26 JAG1 KIT MYB NKX2-1
4 normal MP:0002873 9.02 JAG1 KIT MYB NKX2-1 NOTCH3

Drugs & Therapeutics for Trachea Adenoid Cystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Trachea Adenoid Cystic Carcinoma

Genetic Tests for Trachea Adenoid Cystic Carcinoma

Anatomical Context for Trachea Adenoid Cystic Carcinoma

MalaCards organs/tissues related to Trachea Adenoid Cystic Carcinoma:

40
Trachea, Thyroid, Lung, Thymus, Salivary Gland, T Cells, Liver

Publications for Trachea Adenoid Cystic Carcinoma

Articles related to Trachea Adenoid Cystic Carcinoma:

(showing 46, show less)
# Title Authors PMID Year
1
Tracheal Adenoid Cystic Carcinoma Presented with Chronic Asthma Diagnosed by Bronchial Washing Cytology. 61
32015749 2020
2
Syncope due to tracheal adenoid cystic carcinoma. 61
31304017 2019
3
Impact of positive margins and radiation after tracheal adenoid cystic carcinoma resection on survival. 61
31589850 2019
4
Combined surgery and radiotherapy as curative treatment for tracheal adenoid cystic carcinoma: a case report. 61
30836992 2019
5
Central airway obstruction caused by adenoid cystic carcinoma in pregnancy: a case report and review of the literature. 61
29721318 2018
6
Liver resection for metastases of tracheal adenoid cystic carcinoma: Report of two cases. 61
29778031 2018
7
A 10-year clinical outcome of radiotherapy as an adjuvant or definitive treatment for primary tracheal adenoid cystic carcinoma. 61
29202770 2017
8
Use of Univent tube for intermittent lung isolation during thoracoscopic mediastinal tracheal resection and reconstruction: A case report. 61
29390285 2017
9
Case report of apatinib mesylate treatment in rare advanced tracheal adenoid cystic carcinoma. 61
28892250 2017
10
Percutaneous CT-fluoroscopic-guided radioisotope seed placement for the management of adenoid cystic carcinoma of the trachea. 61
28039009 2017
11
Advanced Tracheal Adenoid Cystic Carcinoma with Thyroid Invasion Mimicking Thyroid Cancer Treated with Definitive Radiation: Case Report and Review of the Literature. 61
28878654 2017
12
Reconstruction of human oncological tracheal defects with xenogenic acellular dermal matrix. 61
27117221 2017
13
Resected Tracheal Adenoid Cystic Carcinoma: Improvements in Outcome at a Single Institution. 61
26431923 2016
14
Video-assisted thoracoscopic surgery tracheal resection and carinal reconstruction for tracheal adenoid cystic carcinoma. 61
26904230 2016
15
Primary tracheal adenoid cystic carcinoma: adjuvant treatment outcome. 61
25412605 2015
16
Laryngeal preservation in managing advanced tracheal adenoid cystic carcinoma. 61
25878915 2015
17
Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report. 61
25120714 2014
18
Tracheal adenoid cystic carcinoma treated by repeated bronchoscopic argon plasma coagulation as a palliative therapy. 61
23575002 2014
19
A case of tracheal adenoid cystic carcinoma in a worker exposed to rubber fumes. 61
24472110 2013
20
[Tracheal adenoid cystic carcinoma treated by complete carinal reconstruction with the help of an ECMO: about a case]. 61
23597633 2013
21
[Tracheal adenoid cystic carcinoma followed by tracheal squamous cell carcinoma: a case report]. 61
23327876 2013
22
Definitive radiotherapy for unresected adenoid cystic carcinoma of the trachea. 61
22553266 2012
23
Prognostic value of pathologic characteristics and resection margins in tracheal adenoid cystic carcinoma. 61
20356756 2010
24
[Tracheal adenoid cystic carcinoma]. 61
21918708 2010
25
Adenoid cystic carcinoma of the trachea metastatic to the nasal cavity: a case report. 61
20013669 2009
26
Primary tracheal adenoid cystic carcinoma with malignant pleural effusion. 61
18310988 2008
27
A long-term survivor after aggressive treatment for tracheal adenoid cystic carcinoma: a case report. 61
17954991 2007
28
[Clinical analysis of 8 cases of tracheal adenoid cystic carcinoma]. 61
21118655 2007
29
Wide sleeve resection of lower trachea through anterior approach with omentopexy. 61
16432124 2006
30
[Tracheal adenoid cystic carcinoma presenting as a thyroid tumor]. 61
17124443 2006
31
Management of difficult airway in intratracheal tumor surgery. 61
15941480 2005
32
Tracheal adenoid cystic carcinoma masquerading asthma: a case report. 61
15494074 2004
33
[Surgery for primary adenoid cystic carcinoma of cervical trachea]. 61
15142459 2004
34
[Surgical treatment of primary tracheal adenoid cystic carcinoma: report of 11 cases]. 61
12921643 2003
35
[A case of tracheal adenoid cystic carcinoma in a young woman]. 61
11732292 2001
36
Primary adenoid cystic carcinoma of the trachea: a case report of a twelve year survivor. 61
7760533 1995
37
Tracheal adenoid cystic carcinoma. 61
1338781 1992
38
[Long-term prognosis of adenoid cystic carcinoma of the trachea]. 61
1661793 1991
39
[Malignant tracheal tumor--differential diagnosis in bronchial asthma]. 61
1665599 1991
40
[A case of primary tracheal adenoid cystic carcinoma performed curative surgical resection]. 61
2165115 1990
41
[Clinical analysis of 11 cases of primary tracheal adenoid cystic carcinoma and review of literature]. 61
2163826 1990
42
[A case of tracheal adenoid cystic carcinoma with symptoms of emphysema aggravated after tracheoplasty]. 61
2846716 1988
43
[A case of tracheal adenoid cystic carcinoma managed by resection of 8 tracheal rings and the lateral half of the right main bronchus and primary anastomosis]. 61
3031351 1987
44
Gingival metastasis from a tracheal adenoid cystic carcinoma. 61
6262470 1981
45
[Removal of tracheal adenoid cystic carcinoma under hypothermia]. 61
4336702 1971
46
[Case of tracheal adenoid-cystic carcinoma]. 61
5627795 1967

Variations for Trachea Adenoid Cystic Carcinoma

Cosmic variations for Trachea Adenoid Cystic Carcinoma:

9 (showing 1, show less)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM92936464 RBM10 upper aerodigestive tract,trachea,carcinoma,adenoid cystic carcinoma c.883C>T p.R295* 23:47179127-47179127 0

Expression for Trachea Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Trachea Adenoid Cystic Carcinoma.

Pathways for Trachea Adenoid Cystic Carcinoma

GO Terms for Trachea Adenoid Cystic Carcinoma

Biological processes related to Trachea Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(showing 9, show less)
# Name GO ID Score Top Affiliating Genes
1 hemopoiesis GO:0030097 9.46 KIT JAG1
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.46 NOTCH3 NKX2-1 MYB JAG1
3 forebrain development GO:0030900 9.43 NOTCH3 NKX2-1
4 negative regulation of neuron differentiation GO:0045665 9.4 NOTCH3 JAG1
5 negative regulation of cell differentiation GO:0045596 9.37 NOTCH3 JAG1
6 positive regulation of smooth muscle cell proliferation GO:0048661 9.32 NOTCH3 MYB
7 positive regulation of Notch signaling pathway GO:0045747 9.26 KIT JAG1
8 negative regulation of Notch signaling pathway GO:0045746 8.96 NOTCH3 JAG1
9 neuron fate commitment GO:0048663 8.62 NOTCH3 NKX2-1

Sources for Trachea Adenoid Cystic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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