MCID: TRC024
MIFTS: 32

Trachea Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Trachea Carcinoma

MalaCards integrated aliases for Trachea Carcinoma:

Name: Trachea Carcinoma 12 15
Pancoast Tumor 12 15 17
Superior Pulmonary Sulcus Syndrome 12
Malignant Superior Sulcus Tumour 12
Malignant Superior Sulcus Tumor 12
Carcinoma of the Trachea 12
Pulmonary Sulcus Tumour 12
Pulmonary Sulcus Tumor 12
Pancoast's Syndrome 12
Pancoast's Tumour 12
Pancoast Syndrome 44
Pancoast's Tumor 12
Pancoast Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4876 DOID:8007
MeSH 44 D010178
UMLS 70 C0030271 C0549471 C0848879 more

Summaries for Trachea Carcinoma

MalaCards based summary : Trachea Carcinoma, also known as pancoast tumor, is related to adenoid cystic carcinoma and lymphoepithelioma-like carcinoma. An important gene associated with Trachea Carcinoma is KRT7 (Keratin 7). The drugs Cisplatin and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include trachea, lung and breast, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Trachea Carcinoma

Diseases in the Trachea Carcinoma family:

Trachea Carcinoma in Situ

Diseases related to Trachea Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 31.5 KRT7 KRT5 KIT
2 lymphoepithelioma-like carcinoma 30.5 KRT7 CD274
3 papillary squamous carcinoma 30.3 KRT7 KRT5
4 tracheal cancer 30.2 LPAR3 KRT5 ALPI
5 keratinizing squamous cell carcinoma 30.2 KRT7 KRT5 CNDP2
6 spindle cell sarcoma 30.0 KRT7 KIT
7 lung leiomyosarcoma 30.0 KRT7 KRT5 KIT
8 pleomorphic carcinoma 30.0 KRT7 KIT CD274
9 large cell carcinoma 30.0 KRT7 KRT5 KIT
10 trachea adenoid cystic carcinoma 29.9 LPAR3 KRT5 KIT ALPI
11 malignant peripheral nerve sheath tumor 29.9 KRT7 KIT CD274
12 basal cell carcinoma 29.7 KRT7 KRT5 KIT CD274
13 adenosquamous carcinoma 29.7 KRT7 KRT5 KIT CD274
14 trachea carcinoma in situ 11.2
15 trachea mucoepidermoid carcinoma 11.0
16 mucoepidermoid carcinoma 10.5
17 squamous cell carcinoma 10.4
18 ureter squamous cell carcinoma 10.3 KRT7 KRT5
19 inverted transitional papilloma 10.3 KRT7 KRT5
20 ceruminoma 10.3 KRT7 KRT5
21 ureter adenocarcinoma 10.3 KRT7 KRT5
22 subareolar duct papillomatosis 10.3 KRT7 KRT5
23 malignant acrospiroma 10.3 KRT7 KRT5
24 nipple benign neoplasm 10.3 KRT7 KRT5
25 auditory system benign neoplasm 10.3 KRT7 KRT5
26 microinvasive cervical squamous cell carcinoma 10.3 KRT7 KRT5
27 trachea leiomyoma 10.3
28 cutaneous mucoepidermoid carcinoma 10.3 KRT7 KRT5
29 external ear carcinoma 10.3 KRT7 KRT5
30 benign breast adenomyoepithelioma 10.3 KRT7 KRT5
31 eccrine adenocarcinoma 10.3 KRT7 KRT5
32 lung clear cell carcinoma 10.3 KRT7 KRT5
33 vulvar apocrine adenocarcinoma 10.3 KRT7 KRT5
34 apocrine adenocarcinoma 10.3 KRT7 KRT5
35 necrotizing sialometaplasia 10.3 KRT7 KRT5
36 sensory organ benign neoplasm 10.3 KRT7 KRT5
37 malignant syringoma 10.3 KRT7 KRT5
38 gastric squamous cell carcinoma 10.3 KRT7 KRT5
39 bile duct mucoepidermoid carcinoma 10.3 KRT7 KRT5
40 squamous cell bile duct carcinoma 10.3 KRT7 KRT5
41 middle ear adenocarcinoma 10.3 KRT7 KRT5
42 breast metaplastic carcinoma 10.3 KRT7 KRT5
43 large cell acanthoma 10.3 KRT7 KRT5
44 cervical adenoid cystic carcinoma 10.3 KRT7 KIT
45 breast mucinous carcinoma 10.3 KRT7 KRT5
46 pericardium cancer 10.3 KRT7 KRT5
47 balloon cell malignant melanoma 10.3 KRT7 KRT5
48 clear cell hidradenoma 10.3 KRT7 KRT5
49 hidradenoma 10.3 KRT7 KRT5
50 eccrine sweat gland cancer 10.3 KRT7 KRT5

Graphical network of the top 20 diseases related to Trachea Carcinoma:



Diseases related to Trachea Carcinoma

Symptoms & Phenotypes for Trachea Carcinoma

GenomeRNAi Phenotypes related to Trachea Carcinoma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.77 CNDP2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-113 9.77 CNDP2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-12 9.77 CD274
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.77 CD274
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.77 CNDP2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-140 9.77 CNDP2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-149 9.77 LPAR3
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.77 KRT5
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.77 CD274
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-176 9.77 CNDP2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.77 KRT5
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.77 CD274
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.77 CD274
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.77 CNDP2 CD274 LPAR3
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.77 CNDP2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-32 9.77 CD274
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-64 9.77 LPAR3
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.77 KRT5 KRT7

Drugs & Therapeutics for Trachea Carcinoma

Drugs for Trachea Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
2
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
3
Etoposide Approved Phase 2 33419-42-0 36462
4
Vindesine Approved, Investigational Phase 2 53643-48-4, 59917-39-4 40839
5
Cobalt Approved, Experimental Phase 2 7440-48-4 104729
6 Tubulin Modulators Phase 2
7 Etoposide phosphate Phase 2
8 Antimitotic Agents Phase 2
9 Antibiotics, Antitubercular Phase 2
10 Mitomycins Phase 2
11 Alkylating Agents Phase 2
12 Anti-Bacterial Agents Phase 2
13 Trace Elements Phase 2
14 Nutrients Phase 2
15 Micronutrients Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Trial of Induction Chemoradiotherapy With Cisplatin/Etoposide Followed by Surgical Resection, Followed by Docetaxel, for Non-Small Cell Lung Cancer Involving the Superior Sulcus (Pancoast Tumors) Completed NCT00062439 Phase 2 cisplatin;docetaxel;etoposide
2 A Phase II Trial of Pre-operative Chemoradiotherapy Followed by Surgical Resection in Pancoast Tumors: Initial Report of Japan Clinical Oncology Group Trial (JCOG 9806) Completed NCT00128037 Phase 2 mitomycin C, vindesine, cisplatin and radiotherapy
3 Induction Chemoradiotherapy Followed by Surgical Resection for Non-small Cell Lung Cancer Involving the Superior Sulcus (Pancoast Tumors): A Phase II Trial Completed NCT00002642 Phase 2 cisplatin;etoposide

Search NIH Clinical Center for Trachea Carcinoma

Cochrane evidence based reviews: pancoast syndrome

Genetic Tests for Trachea Carcinoma

Anatomical Context for Trachea Carcinoma

MalaCards organs/tissues related to Trachea Carcinoma:

40
Trachea, Lung, Breast, Colon, Thymus, Liver, Heart

Publications for Trachea Carcinoma

Articles related to Trachea Carcinoma:

(show top 50) (show all 186)
# Title Authors PMID Year
1
Pathologic complete response after neoadjuvant tislelizumab and chemotherapy for Pancoast tumor: A case report. 61
33656285 2021
2
Pancoast Tumor as the Initial Presentation of a Metastatic Colon Adenocarcinoma. 61
33747663 2021
3
Primary pulmonary angiosarcoma presenting as Pancoast tumor. 61
33435693 2021
4
Estimated direct costs of non-small cell lung cancer by stage at diagnosis and disease management phase: A whole-disease model. 61
33219738 2021
5
Primary plasma cell leukemia mimicking a Pancoast tumor. 61
32833248 2020
6
Unilateral autoimmune inner ear disease in a patient with lung cancer treated with nivolumab. 61
32995031 2020
7
Pancoast Tumor: The Overlooked Etiology of Shoulder Pain in Smokers. 61
32913177 2020
8
[Do we inspecting the patient face who has shoulder pain?] 61
32297960 2020
9
Harlequin sign in Pancoast tumor. 61
31732238 2020
10
T1 Erector Spinae Plane Block Catheter As a Novel Treatment Modality for Pancoast Tumor Pain. 61
31857924 2019
11
Superior sulcus tumor disguised as cervical radiculopathy with metastasis to brachial plexus. 61
31656428 2019
12
[Surgical Treatment for Apical Invading Lung Cancer]. 61
31582706 2019
13
The new 8th TNM staging system of lung cancer and its potential imaging interpretation pitfalls and limitations with CT image demonstrations. 61
31295144 2019
14
An in-silico quality assurance study of contouring target volumes in thoracic tumors within a cooperative group setting. 61
30775563 2019
15
Esophageal ultrasound with ultrasound bronchoscope (EUS-B) guided left adrenal biopsy: Case report with review of literature. 61
30603608 2019
16
Huge maxillary metastasis of an aggressive Pancoast tumor -A case report. 61
31559001 2019
17
Robotic Hybrid Approach for an Anterior Pancoast Tumor in a Severely Obese Patient. 61
29654726 2018
18
A novel muscle-sparing high thoracotomy for upper thoracic spine resection and reconstruction. 61
29218482 2018
19
Primary Lung Signet Ring Cell Carcinoma Presenting as a Cavitary Pancoast Tumor in a 32-Year-Old Man. 61
29800025 2018
20
Less Invasive Approach to Pancoast Tumor in a Partitioned Incision. 61
28484150 2017
21
Surgical Treatment of Superior Sulcus Tumors: A 15-Year Single-center Experience. 61
28684003 2017
22
A rare presentation of myxofibrosarcoma as a Pancoast tumor: a case report. 61
28264709 2017
23
Pancoast tumor approach through oesophagus. 61
28913160 2017
24
Diagnosing and treating pancoast tumors. 61
27786592 2016
25
Ultrasonographic Imaging of a Pancoast Tumor Presenting with Breakthrough Pain and Not Visualized by Plane Radiograph. 61
28025378 2016
26
VATS lobectomy combined with limited Shaw-Paulson thoracotomy for posterolateral Pancoast tumor. 61
26429643 2016
27
An unusual cause of acute headache: subarachnoid free air secondary to spontaneous bronchopleurodurosubarachnoid fistula from a Pancoast tumor. 61
27594957 2016
28
Extracorporeal Lung Support as a Bridge to Airway Stenting and Radiotherapy for Airway-Obstructing Pancoast Tumor. 61
27343540 2016
29
Resection of the First Rib With Preservation of the T1 Nerve Root in Pancoast Tumors of the Lung. 61
27556670 2016
30
Hybrid video-assisted and limited open (VALO) resection of superior sulcus tumors. 61
26198898 2016
31
Pancoast Tumor of the Lung. 61
27150220 2016
32
Video-assisted pulmonary lobectomy combined with transmanubrial approach for anterior Pancoast tumor resection: case report. 61
27079507 2016
33
Painful Metastasis in the Lunate Bone as the First Symptom of a Pancoast Tumor; a Case Report and Review of the Literature. 61
26578844 2015
34
Combined treatment modalities in Pancoast tumor: results of a monocentric retrospective study. 61
26730751 2015
35
A Case of Pancoast Tumor with Unusual Presentation. 61
27917240 2015
36
Use of FDG PET/CT in Patients with Pancoast Tumors: Does It Add Any Contribution to Patient Management? 61
26367245 2015
37
Expert's comment concerning "Chest wall reconstruction after en bloc Pancoast tumor resection with the use of MatrixRib and SILC Fixation systems: technical note" (Marcin Czyz, Emmanuel Addae-Boateng, Bronek M. Boszczyk): Update in Pancoast Tobias en bloc resections. 61
26315146 2015
38
Intraoperative Neurophysiological Monitoring (IONM) for Cordotomy Procedures. 61
26630809 2015
39
[Outcome of surgical treatment for Pancoast lung carcinoma in Iceland]. 61
26158627 2015
40
Case Report: En Bloc Resection of Pancoast Tumor with Adjuvant Aortic Endograft and Chemoradiation. 61
26306134 2015
41
The "cut-in patch-out" technique for Pancoast tumor resections results in postoperative pain reduction: a case control study. 61
25265907 2014
42
Therapeutic modalities for Pancoast tumors. 61
24672693 2014
43
Pulmonary Mycobacterium kansasii Infection Mimicking Malignancy on the (18)F-FDG PET Scan in a Patient Receiving Etanercept: A Case Report and Literature Review. 61
25389506 2014
44
[Pancoast tumor. A clinical case]. 61
25036449 2014
45
Prolongation of life by adoptive cell therapy with cascade primed immune cells in four patients with non-small cell lung cancer stages IIIB and IV and a pancoast tumor: a case series. 61
24330627 2013
46
Hyponatremia associated with unilateral hand weakness and numbness: a case report. 61
24404545 2013
47
Superior sulcus (Pancoast) tumors: current evidence on diagnosis and radical treatment. 61
24102007 2013
48
[Surgical treatment for Pancoast tumor]. 61
23898706 2013
49
Delayed paraplegia due to "surgiceloma" following thoracotomy for a Pancoast tumor. 61
23591929 2013
50
Pancoast syndrome: A rare presentation of non-Hodgkin's lymphoma. 61
24049257 2013

Variations for Trachea Carcinoma

Expression for Trachea Carcinoma

Search GEO for disease gene expression data for Trachea Carcinoma.

Pathways for Trachea Carcinoma

GO Terms for Trachea Carcinoma

Sources for Trachea Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....