MCID: TRC024
MIFTS: 38

Trachea Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Trachea Carcinoma

MalaCards integrated aliases for Trachea Carcinoma:

Name: Trachea Carcinoma 12 15
Pancoast Tumor 12 15 17
Superior Pulmonary Sulcus Syndrome 12
Malignant Superior Sulcus Tumor 12
Carcinoma of the Trachea 12
Pulmonary Sulcus Tumor 12
Pancoast's Syndrome 12
Pancoast's Tumour 12
Pancoast Syndrome 45
Pancoast's Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4876 DOID:8007
MeSH 45 D010178
SNOMED-CT 69 80367008

Summaries for Trachea Carcinoma

Disease Ontology : 12 A tracheal cancer that effects the airway that leads from the larynx to the bronchi.

MalaCards based summary : Trachea Carcinoma, also known as pancoast tumor, is related to lung oat cell carcinoma and small cell cancer of the lung. An important gene associated with Trachea Carcinoma is SMUG1 (Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1). The drugs Cisplatin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include trachea, bone and b cells, and related phenotypes are behavior/neurological and mortality/aging

Related Diseases for Trachea Carcinoma

Diseases in the Trachea Carcinoma family:

Trachea Carcinoma in Situ

Diseases related to Trachea Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 lung oat cell carcinoma 30.8 AVP ENO2
2 small cell cancer of the lung 29.6 AVP CEACAM5 ENO2 GRP
3 tracheal cancer 28.7 AFP AVP CEACAM5 EEF2 ENO2 GRP
4 trachea carcinoma in situ 12.2
5 trachea mucoepidermoid carcinoma 11.1
6 adenoid cystic carcinoma 10.6
7 extragonadal nonseminomatous germ cell tumor 10.4 AFP SMUG1
8 bladder calculus 10.4 PGRMC1 SMUG1
9 sternum cancer 10.4 AFP SMUG1
10 corpus luteum cyst 10.4 AFP SMUG1
11 extragonadal germ cell cancer 10.4 AFP SMUG1
12 klatskin's tumor 10.4 PGRMC1 SMUG1
13 mediastinal cancer 10.4 AFP SMUG1
14 mature teratoma 10.4 AFP SMUG1
15 mucoepidermoid carcinoma 10.3
16 secondary hypertrophic osteoarthropathy 10.3 AVP SMUG1
17 brain germinoma 10.3 AFP AVP
18 gallbladder small cell carcinoma 10.3 ENO2 SMUG1
19 tuberculous epididymitis 10.3 AFP AVP
20 rectum squamous cell carcinoma 10.3 SMUG1 TNFRSF1B
21 sphenoid sinusitis 10.3 AVP PGRMC1
22 central nervous system germ cell tumor 10.3 AFP AVP
23 malignant sertoli cell tumor 10.3 AFP ENO2
24 supraglottis cancer 10.3 ENO2 PGRMC1
25 superior mesenteric artery syndrome 10.3 AVP PGRMC1
26 chondromalacia 10.3 SMUG1 TNFRSF1B
27 granulomatous myositis 10.3 SMUG1 TNFRSF1B
28 endometrial small cell carcinoma 10.3 AFP ENO2
29 heart sarcoma 10.3 ENO2 SMUG1
30 gallbladder squamous cell carcinoma 10.3 CEACAM5 SMUG1
31 malignant acrospiroma 10.3 CEACAM5 SMUG1
32 plexopathy 10.3 AVP SMUG1
33 malignant spiradenoma 10.3 CEACAM5 SMUG1
34 peliosis hepatis 10.3 AFP SMUG1
35 tolosa-hunt syndrome 10.3 CEACAM5 SMUG1
36 trachea adenoid cystic carcinoma 10.3 MYB PGRMC1 SMUG1
37 mucinous cystadenofibroma 10.3 AFP CEACAM5
38 eccrine adenocarcinoma 10.3 CEACAM5 SMUG1
39 bronchus cancer 10.3 AVP ENO2
40 chronic gonococcal salpingitis 10.3 MCL1 TNFRSF1B
41 bladder neck obstruction 10.3 AFP TNFRSF1B
42 urachal adenocarcinoma 10.3 AFP CEACAM5
43 olfactory nerve neoplasm 10.2 AVP ENO2
44 prostate squamous cell carcinoma 10.2 CEACAM5 SMUG1
45 hematocele of tunica vaginalis testis 10.2 AFP CEACAM5
46 pancreatic cystadenocarcinoma 10.2 AFP CEACAM5
47 pericardium cancer 10.2 ENO2 SMUG1
48 descending colon cancer 10.2 CEACAM5 SMUG1
49 bile duct cystadenocarcinoma 10.2 AFP CEACAM5
50 liver sarcoma 10.2 AFP CEACAM5

Graphical network of the top 20 diseases related to Trachea Carcinoma:



Diseases related to Trachea Carcinoma

Symptoms & Phenotypes for Trachea Carcinoma

MGI Mouse Phenotypes related to Trachea Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 AFP AVP B4GALT5 ENO2 GRP PGRMC1
2 mortality/aging MP:0010768 9.32 AFP AVP B4GALT5 EEF2 MCL1 MYB

Drugs & Therapeutics for Trachea Carcinoma

Drugs for Trachea Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 441203 84093 2767
2
Etoposide Approved Phase 2 33419-42-0 36462
3
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
4
Vindesine Approved, Investigational Phase 2 59917-39-4, 53643-48-4 40839
5
Cobalt Approved, Experimental Phase 2 7440-48-4 104729
6
nivolumab Approved Phase 2 946414-94-4
7
Ipilimumab Approved Phase 2 477202-00-9
8 Etoposide phosphate Phase 2
9 Topoisomerase Inhibitors Phase 2
10 Antimitotic Agents Phase 2
11 Antineoplastic Agents, Phytogenic Phase 2
12 Alkylating Agents Phase 2
13 Antibiotics, Antitubercular Phase 2
14 Nucleic Acid Synthesis Inhibitors Phase 2
15 Mitomycins Phase 2
16 Anti-Bacterial Agents Phase 2
17 Antibodies, Monoclonal Phase 2
18 Antineoplastic Agents, Immunological Phase 2
19 Immunoglobulins Phase 2
20 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 S0220: Chemoradiotherapy Followed By Surgery and Docetaxel in Treating Patients With Pancoast Tumors Completed NCT00062439 Phase 2 cisplatin;docetaxel;etoposide
2 Trial of Pre-operative Chemoradiotherapy Followed by Surgical Resection in Pancoast Tumors (JCOG 9806) Completed NCT00128037 Phase 2 mitomycin C, vindesine, cisplatin and radiotherapy
3 Combined Modality Treatment for Resectable Non-Small Cell Superior Sulcus Tumors Completed NCT00984997 Phase 2 Cisplatin;Etoposide
4 SWOG-9416: Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Stage III Non-small Cell Lung Cancer Completed NCT00002642 Phase 2 cisplatin;etoposide
5 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2

Search NIH Clinical Center for Trachea Carcinoma

Cochrane evidence based reviews: pancoast syndrome

Genetic Tests for Trachea Carcinoma

Anatomical Context for Trachea Carcinoma

MalaCards organs/tissues related to Trachea Carcinoma:

42
Trachea, Bone, B Cells

Publications for Trachea Carcinoma

Articles related to Trachea Carcinoma:

(show top 50) (show all 71)
# Title Authors Year
1
Robotic Hybrid Approach for an Anterior Pancoast Tumor in a Severely Obese Patient. ( 29654726 )
2018
2
Primary Lung Signet Ring Cell Carcinoma Presenting as a Cavitary Pancoast Tumor in a 32-Year-Old Man. ( 29800025 )
2018
3
A rare presentation of myxofibrosarcoma as a Pancoast tumor: a case report. ( 28264709 )
2017
4
Pancoast tumor approach through oesophagus. ( 28913160 )
2017
5
Less Invasive Approach to Pancoast Tumor in a Partitioned Incision. ( 28484150 )
2017
6
Ultrasonographic Imaging of a Pancoast Tumor Presenting with Breakthrough Pain and Not Visualized by Plane Radiograph. ( 28025378 )
2016
7
Ultrasonographic Imaging of a Pancoast Tumor Presenting with Breakthrough Pain and Not Visualized by Plane Radiograph. ( 27257289 )
2016
8
Pancoast Tumor of the Lung. ( 27150220 )
2016
9
Video-assisted pulmonary lobectomy combined with transmanubrial approach for anterior Pancoast tumor resection: case report. ( 27079507 )
2016
10
An unusual cause of acute headache: subarachnoid free air secondary to spontaneous bronchopleurodurosubarachnoid fistula from a Pancoast tumor. ( 27594957 )
2016
11
Combined treatment modalities in Pancoast tumor: results of a monocentric retrospective study. ( 26730751 )
2015
12
Expert's comment concerning "Chest wall reconstruction after en bloc Pancoast tumor resection with the use of MatrixRib and SILC Fixation systems: technical note" (Marcin Czyz, Emmanuel Addae-Boateng, Bronek M. Boszczyk) : Update in Pancoast Tobias en bloc resections. ( 26315146 )
2015
13
Case Report: En Bloc Resection of Pancoast Tumor with Adjuvant Aortic Endograft and Chemoradiation. ( 26306134 )
2015
14
Painful Metastasis in the Lunate Bone as the First Symptom of a Pancoast Tumor; a Case Report and Review of the Literature. ( 26578844 )
2015
15
A Case of Pancoast Tumor with Unusual Presentation. ( 27917240 )
2015
16
VATS lobectomy combined with limited Shaw-Paulson thoracotomy for posterolateral Pancoast tumor. ( 26429643 )
2015
17
The "cut-in patch-out" technique for Pancoast tumor resections results in postoperative pain reduction: a case control study. ( 25265907 )
2014
18
Pancoast tumor: the role of magnetic resonance imaging. ( 23607032 )
2013
19
Delayed paraplegia due to "surgiceloma" following thoracotomy for a Pancoast tumor. ( 23591929 )
2013
20
Prolongation of life by adoptive cell therapy with cascade primed immune cells in four patients with non-small cell lung cancer stages IIIB and IV and a pancoast tumor: a case series. ( 24330627 )
2013
21
Pancoast tumor: a modern perspective on an old problem. ( 23702478 )
2013
22
Squamous cell carcinoma on the remaining sequel of tuberculosis, presented as pancoast tumor 8 years later. ( 25191429 )
2012
23
Hepatoid pancoast tumor. A case report and review of the literature. ( 22677427 )
2012
24
Images in emergency medicine. Adult female with malignant pain. Horner's syndrome as a result of a Pancoast tumor. ( 21353907 )
2011
25
Pulmonary echinococcosis mimicking Pancoast tumor. ( 19660333 )
2010
26
Diffuse large B-cell lymphoma presenting as pancoast tumor. ( 20385989 )
2010
27
Paravertebral cervical nerve block in a patient suffering from a Pancoast tumor. ( 21134120 )
2010
28
Bone single photon emission computed tomography (SPECT) in a patient with Pancoast tumor: a case report. ( 21120438 )
2010
29
Tension pneumocephalus complicating Pancoast tumor resection. ( 19254944 )
2009
30
Malignant triton tumor of the brachial plexus invading the left thoracic inlet: a rare differential diagnosis of pancoast tumor. ( 19096322 )
2009
31
Hydatid disease of the ribs mimicking pancoast tumor: report of two cases. ( 18027344 )
2007
32
Pulmonary leiomyosarcoma presenting as a pancoast tumor. ( 17673374 )
2007
33
Anterior approach for Pancoast tumor resection. ( 24415052 )
2007
34
Pancoast tumor resection with preservation of brachial plexus and hand function. ( 17613206 )
2007
35
Multimodality therapy for Pancoast tumor. ( 16955087 )
2006
36
Delay by patients and doctors in treatment of Pancoast tumor. ( 16865645 )
2006
37
Management of a superior sulcus (pancoast) tumor. ( 16370449 )
2005
38
Reflex sympathetic dystrophy and pancoast tumor. ( 15365437 )
2004
39
Elimination of Pancoast tumor by carboplatin, paclitaxel, and concurrent radiation. ( 15609647 )
2004
40
Cervicobrachialgia and pancoast tumor: value of standard anteroposterior cervical radiographs in early diagnosis. ( 15553951 )
2004
41
Tuberculosis presenting as Pancoast tumor. ( 14602329 )
2003
42
Clinical images: Wegener's granulomatosis presenting as Pancoast tumor. ( 10693892 )
2000
43
Pain-relieving posterior rod fixation with segmental sublaminar wiring for Pancoast tumor invading the vertebrae. ( 10721947 )
1999
44
Superior sulcus (Pancoast) tumor: experience with 105 patients. ( 9692463 )
1998
45
Complete excision of the lower trunk and C8 and T1 nerve roots in a patient with Pancoast tumor with a resulting fully functional hand. ( 9238751 )
1997
46
Subarachnoid-pleural fistula after resection of a pancoast tumor with hyponatremia. ( 7677501 )
1995
47
Combined radiosurgical treatment of Pancoast tumor. ( 8279890 )
1994
48
Pancoast tumor as a cause of reflex sympathetic dystrophy. ( 8229248 )
1993
49
Surgical treatment of Pancoast tumor. ( 8320251 )
1993
50
Primary hemangiopericytoma presenting as a Pancoast tumor. ( 8431033 )
1993

Variations for Trachea Carcinoma

Expression for Trachea Carcinoma

Search GEO for disease gene expression data for Trachea Carcinoma.

Pathways for Trachea Carcinoma

GO Terms for Trachea Carcinoma

Biological processes related to Trachea Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of anoikis GO:2000811 8.62 CEACAM5 MCL1

Molecular functions related to Trachea Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.62 AVP GRP

Sources for Trachea Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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