MCID: TRC002
MIFTS: 30

Trachea Carcinoma in Situ

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Trachea Carcinoma in Situ

MalaCards integrated aliases for Trachea Carcinoma in Situ:

Name: Trachea Carcinoma in Situ 12 15
Carcinoma in Situ of Trachea 12 71
Tracheal Carcinoma in Situ 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8802
ICD9CM 34 231.1
NCIt 49 C3639
SNOMED-CT 67 92772005
ICD10 32 D02.1
UMLS 71 C0154070

Summaries for Trachea Carcinoma in Situ

Disease Ontology : 12 An in situ carcinoma that is located in the trachea.

MalaCards based summary : Trachea Carcinoma in Situ, also known as carcinoma in situ of trachea, is related to squamous cell papilloma and epithelial-myoepithelial carcinoma, and has symptoms including dyspnea, hemoptysis and coughing. An important gene associated with Trachea Carcinoma in Situ is HHEX (Hematopoietically Expressed Homeobox), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Endometrial cancer. Affiliated tissues include trachea, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Trachea Carcinoma in Situ

Diseases in the Trachea Carcinoma family:

Trachea Carcinoma in Situ

Diseases related to Trachea Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 squamous cell papilloma 10.1 KRT14 HRAS
2 epithelial-myoepithelial carcinoma 10.0 KRT14 HRAS
3 myoepithelial carcinoma 10.0 KRT14 HRAS
4 skin papilloma 10.0 KRT14 HRAS
5 ameloblastic carcinoma 10.0 KRT14 CDKN2A
6 spitz nevus 10.0 HRAS CDKN2A
7 adult malignant schwannoma 10.0 HRAS CDKN2A
8 skin benign neoplasm 10.0 KRT14 HRAS
9 ischemic fasciitis 10.0 KRT14 CDKN2A
10 borst-jadassohn intraepidermal carcinoma 10.0 KRT14 CDKN2A
11 nodular malignant melanoma 10.0 HRAS CDKN2A
12 vulvar disease 10.0 HRAS CDKN2A
13 spindle cell carcinoma 10.0 KRT14 HRAS
14 basaloid squamous cell carcinoma 10.0 KRT14 CDKN2A
15 plexiform neurofibroma 10.0 HRAS CDKN2A
16 tonsil cancer 9.9 KRT14 CDKN2A
17 actinic keratosis 9.9 HRAS CDKN2A
18 papillary adenoma 9.9 KRAS HRAS
19 signet ring basal cell carcinoma 9.9 KRAS HRAS
20 nasal cavity adenocarcinoma 9.9 KRAS HRAS
21 serous cystadenocarcinoma 9.9 KRAS HRAS
22 carcinosarcoma 9.9 KRAS HRAS
23 ampulla of vater neoplasm 9.9 KRAS HRAS
24 periampullary adenoma 9.9 KRAS HRAS
25 acneiform dermatitis 9.9 KRAS HRAS
26 myh-associated polyposis 9.9 KRAS HRAS
27 appendix adenocarcinoma 9.9 KRAS HRAS
28 mucinous lung adenocarcinoma 9.9 KRAS HRAS
29 wolffian duct adenocarcinoma 9.9 KRAS HRAS
30 pancreatic intraductal papillary-mucinous neoplasm 9.9 KRAS HRAS
31 ascending colon cancer 9.9 KRAS HRAS
32 biliary tract benign neoplasm 9.9 KRAS HRAS
33 schimmelpenning-feuerstein-mims syndrome 9.9 KRAS HRAS
34 ovarian mucinous neoplasm 9.8 KRAS HRAS
35 tumor of exocrine pancreas 9.8 KRAS HRAS
36 pancreatic acinar cell adenocarcinoma 9.8 KRAS HRAS
37 pulmonic stenosis 9.8 KRAS HRAS
38 appendix disease 9.8 KRAS HRAS
39 small intestine adenocarcinoma 9.8 KRAS HRAS
40 in situ pulmonary adenocarcinoma 9.8 KRAS HRAS
41 core binding factor acute myeloid leukemia 9.8 KRAS HRAS
42 paronychia 9.8 KRAS HRAS
43 appendix cancer 9.8 KRAS HRAS
44 duodenum adenocarcinoma 9.8 KRAS HRAS
45 bile duct cysts 9.8 KRAS HRAS
46 endometrioid ovary carcinoma 9.8 KRAS HRAS
47 rectosigmoid cancer 9.8 KRAS HRAS
48 nasal cavity cancer 9.8 KRAS HRAS
49 female reproductive endometrioid cancer 9.8 KRAS HRAS
50 uterine body mixed cancer 9.8 KRAS HRAS

Graphical network of the top 20 diseases related to Trachea Carcinoma in Situ:



Diseases related to Trachea Carcinoma in Situ

Symptoms & Phenotypes for Trachea Carcinoma in Situ

UMLS symptoms related to Trachea Carcinoma in Situ:


dyspnea, hemoptysis, coughing, hoarseness

GenomeRNAi Phenotypes related to Trachea Carcinoma in Situ according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.53 HRAS KRAS
2 Decreased viability GR00106-A-0 9.53 KRAS
3 Decreased viability GR00221-A-1 9.53 CDKN2A HRAS KRAS
4 Decreased viability GR00221-A-2 9.53 HRAS KRAS
5 Decreased viability GR00221-A-3 9.53 CDKN2A HRAS
6 Decreased viability GR00221-A-4 9.53 CDKN2A
7 Decreased viability GR00301-A 9.53 KRAS
8 Decreased viability GR00381-A-1 9.53 KRAS
9 Decreased viability GR00402-S-2 9.53 CDKN2A HRAS KRAS

MGI Mouse Phenotypes related to Trachea Carcinoma in Situ:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.67 HHEX HRAS KRAS KRT14
2 endocrine/exocrine gland MP:0005379 9.65 CDKN2A HHEX HRAS KRAS KRT14
3 digestive/alimentary MP:0005381 9.62 CDKN2A HRAS KRAS KRT14
4 neoplasm MP:0002006 9.46 CDKN2A HRAS KRAS KRT14
5 pigmentation MP:0001186 9.13 CDKN2A KRAS KRT14
6 respiratory system MP:0005388 9.02 CDKN2A HHEX HRAS KRAS KRT14

Drugs & Therapeutics for Trachea Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Trachea Carcinoma in Situ

Genetic Tests for Trachea Carcinoma in Situ

Anatomical Context for Trachea Carcinoma in Situ

The Foundational Model of Anatomy Ontology organs/tissues related to Trachea Carcinoma in Situ:

19
Trachea

MalaCards organs/tissues related to Trachea Carcinoma in Situ:

40
Trachea

Publications for Trachea Carcinoma in Situ

Variations for Trachea Carcinoma in Situ

Expression for Trachea Carcinoma in Situ

Search GEO for disease gene expression data for Trachea Carcinoma in Situ.

Pathways for Trachea Carcinoma in Situ

Pathways related to Trachea Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.6 KRAS HRAS CDKN2A
2
Show member pathways
12.57 KRAS HRAS CDKN2A
3 12.55 KRAS HRAS CDKN2A
4
Show member pathways
12.52 KRAS HRAS CDKN2A
5
Show member pathways
12.46 KRAS HRAS CDKN2A
6
Show member pathways
12.37 KRT14 KRAS HRAS
7
Show member pathways
12.36 KRAS HRAS CDKN2A
8 12.23 KRAS HRAS CDKN2A
9 11.95 KRAS HRAS CDKN2A
10 11.85 KRAS HRAS CDKN2A
11 11.64 KRAS HRAS CDKN2A
12 11.61 KRAS HRAS
13
Show member pathways
11.57 KRAS HRAS
14 11.48 KRAS HRAS
15
Show member pathways
11.45 KRAS HRAS
16 11.44 KRAS HRAS
17 11.43 KRAS HRAS
18 11.39 KRAS HRAS
19 11.39 KRAS HRAS CDKN2A
20 11.36 KRAS HRAS
21 11.27 KRAS HRAS
22 11.21 KRAS HRAS
23 11.18 KRAS HRAS CDKN2A
24 11.15 KRAS HRAS
25 11.07 KRAS HRAS
26 11.01 KRAS HRAS
27 11 KRAS HRAS
28
Show member pathways
10.97 KRAS HRAS
29
Show member pathways
10.91 KRAS HRAS
30 10.84 KRAS HRAS
31 10.8 KRAS HRAS
32 10.71 KRAS HRAS
33 10.66 KRAS HRAS CDKN2A
34 10.44 KRAS HRAS

GO Terms for Trachea Carcinoma in Situ

Biological processes related to Trachea Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.58 KRAS HRAS CDKN2A
2 regulation of protein stability GO:0031647 9.46 KRAS CDKN2A
3 positive regulation of MAP kinase activity GO:0043406 9.43 KRAS HRAS
4 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.37 HHEX CDKN2A
5 cellular senescence GO:0090398 9.32 HRAS CDKN2A
6 regulation of long-term neuronal synaptic plasticity GO:0048169 9.26 KRAS HRAS
7 positive regulation of cellular senescence GO:2000774 9.16 KRAS CDKN2A
8 response to isolation stress GO:0035900 8.96 KRAS HRAS
9 Ras protein signal transduction GO:0007265 8.8 KRAS HRAS CDKN2A

Molecular functions related to Trachea Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GDP binding GO:0019003 8.62 KRAS HRAS

Sources for Trachea Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....