MCID: TRC002
MIFTS: 30

Trachea Carcinoma in Situ

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Trachea Carcinoma in Situ

MalaCards integrated aliases for Trachea Carcinoma in Situ:

Name: Trachea Carcinoma in Situ 12 15
Carcinoma in Situ of Trachea 12 71
Tracheal Carcinoma in Situ 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8802
ICD9CM 34 231.1
NCIt 49 C3639
SNOMED-CT 67 92772005
ICD10 32 D02.1
UMLS 71 C0154070

Summaries for Trachea Carcinoma in Situ

Disease Ontology : 12 An in situ carcinoma that is located in the trachea.

MalaCards based summary : Trachea Carcinoma in Situ, also known as carcinoma in situ of trachea, is related to epithelial-myoepithelial carcinoma and myoepithelial carcinoma, and has symptoms including dyspnea, hemoptysis and coughing. An important gene associated with Trachea Carcinoma in Situ is HHEX (Hematopoietically Expressed Homeobox), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Endometrial cancer. Affiliated tissues include trachea, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Trachea Carcinoma in Situ

Diseases in the Trachea Carcinoma family:

Trachea Carcinoma in Situ

Diseases related to Trachea Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 epithelial-myoepithelial carcinoma 10.0 KRT14 HRAS
2 myoepithelial carcinoma 10.0 KRT14 HRAS
3 prostate squamous cell carcinoma 10.0 HRAS CDKN2A
4 ameloblastic carcinoma 10.0 KRT14 CDKN2A
5 spitz nevus 10.0 HRAS CDKN2A
6 adult malignant schwannoma 10.0 HRAS CDKN2A
7 spitzoid melanoma 10.0 HRAS CDKN2A
8 spindle cell carcinoma 10.0 KRT14 HRAS
9 malignant spindle cell melanoma 10.0 HRAS CDKN2A
10 borst-jadassohn intraepidermal carcinoma 10.0 KRT14 CDKN2A
11 vulvar disease 10.0 HRAS CDKN2A
12 nodular malignant melanoma 10.0 HRAS CDKN2A
13 acral lentiginous melanoma 10.0 HRAS CDKN2A
14 basaloid squamous cell carcinoma 10.0 KRT14 CDKN2A
15 skin benign neoplasm 10.0 KRT14 HRAS
16 tonsil cancer 9.9 KRT14 CDKN2A
17 vulva cancer 9.9 HRAS CDKN2A
18 melanoma in congenital melanocytic nevus 9.9 HRAS CDKN2A
19 actinic keratosis 9.9 HRAS CDKN2A
20 signet ring basal cell carcinoma 9.9 KRAS HRAS
21 cobblestone retinal degeneration 9.9 KRAS HRAS
22 nasal cavity adenocarcinoma 9.9 KRAS HRAS
23 ampulla of vater neoplasm 9.9 KRAS HRAS
24 villous adenoma 9.9 KRAS HRAS
25 descending colon cancer 9.9 KRAS HRAS
26 periampullary adenoma 9.9 KRAS HRAS
27 adenosquamous lung carcinoma 9.9 KRAS HRAS
28 acneiform dermatitis 9.9 KRAS HRAS
29 transverse colon cancer 9.9 KRAS HRAS
30 appendiceal neoplasm 9.9 KRAS HRAS
31 gallbladder benign neoplasm 9.9 KRAS HRAS
32 myh-associated polyposis 9.9 KRAS HRAS
33 appendix adenocarcinoma 9.9 KRAS HRAS
34 mucinous lung adenocarcinoma 9.9 KRAS HRAS
35 wolffian duct adenocarcinoma 9.9 KRAS HRAS
36 ascending colon cancer 9.9 KRAS HRAS
37 biliary tract benign neoplasm 9.8 KRAS HRAS
38 pancreatic acinar cell adenocarcinoma 9.8 KRAS HRAS
39 endosalpingiosis 9.8 KRAS HRAS
40 core binding factor acute myeloid leukemia 9.8 KRAS HRAS
41 lung carcinoma in situ 9.8 KRAS HRAS
42 appendix disease 9.8 KRAS HRAS
43 paronychia 9.8 KRAS HRAS
44 duodenum adenocarcinoma 9.8 KRAS HRAS
45 pulmonary adenocarcinoma in situ 9.8 KRAS HRAS
46 bile duct cysts 9.8 KRAS HRAS
47 papillary adenoma 9.8 KRAS HRAS
48 appendix cancer 9.8 KRAS HRAS
49 large intestine adenocarcinoma 9.8 KRAS HRAS
50 oculoectodermal syndrome 9.8 KRAS HRAS

Graphical network of the top 20 diseases related to Trachea Carcinoma in Situ:



Diseases related to Trachea Carcinoma in Situ

Symptoms & Phenotypes for Trachea Carcinoma in Situ

UMLS symptoms related to Trachea Carcinoma in Situ:


dyspnea, hemoptysis, coughing, hoarseness

GenomeRNAi Phenotypes related to Trachea Carcinoma in Situ according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.53 HRAS KRAS
2 Decreased viability GR00055-A-2 9.53 HRAS KRAS
3 Decreased viability GR00055-A-3 9.53 KRAS
4 Decreased viability GR00106-A-0 9.53 KRAS
5 Decreased viability GR00221-A-1 9.53 CDKN2A HRAS KRAS
6 Decreased viability GR00221-A-2 9.53 HRAS KRAS
7 Decreased viability GR00221-A-3 9.53 CDKN2A HRAS
8 Decreased viability GR00221-A-4 9.53 CDKN2A
9 Decreased viability GR00301-A 9.53 KRAS
10 Decreased viability GR00381-A-1 9.53 KRAS

MGI Mouse Phenotypes related to Trachea Carcinoma in Situ:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.67 HHEX HRAS KRAS KRT14
2 endocrine/exocrine gland MP:0005379 9.65 CDKN2A HHEX HRAS KRAS KRT14
3 digestive/alimentary MP:0005381 9.62 CDKN2A HRAS KRAS KRT14
4 neoplasm MP:0002006 9.46 CDKN2A HRAS KRAS KRT14
5 pigmentation MP:0001186 9.13 CDKN2A KRAS KRT14
6 respiratory system MP:0005388 9.02 CDKN2A HHEX HRAS KRAS KRT14

Drugs & Therapeutics for Trachea Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Trachea Carcinoma in Situ

Genetic Tests for Trachea Carcinoma in Situ

Anatomical Context for Trachea Carcinoma in Situ

The Foundational Model of Anatomy Ontology organs/tissues related to Trachea Carcinoma in Situ:

19
Trachea

MalaCards organs/tissues related to Trachea Carcinoma in Situ:

40
Trachea

Publications for Trachea Carcinoma in Situ

Variations for Trachea Carcinoma in Situ

Expression for Trachea Carcinoma in Situ

Search GEO for disease gene expression data for Trachea Carcinoma in Situ.

Pathways for Trachea Carcinoma in Situ

Pathways related to Trachea Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 KRAS HRAS CDKN2A
2
Show member pathways
12.58 KRAS HRAS CDKN2A
3 12.55 KRAS HRAS CDKN2A
4
Show member pathways
12.47 KRAS HRAS CDKN2A
5
Show member pathways
12.4 KRAS HRAS CDKN2A
6
Show member pathways
12.37 KRAS HRAS CDKN2A
7
Show member pathways
12.36 KRT14 KRAS HRAS
8 12.23 KRAS HRAS CDKN2A
9 11.92 KRAS HRAS CDKN2A
10
Show member pathways
11.87 KRAS HRAS
11 11.85 KRAS HRAS CDKN2A
12 11.63 KRAS HRAS CDKN2A
13 11.61 KRAS HRAS
14
Show member pathways
11.58 KRAS HRAS
15 11.49 KRAS HRAS
16 11.47 KRAS HRAS
17
Show member pathways
11.45 KRAS HRAS
18 11.43 KRAS HRAS
19 11.4 KRAS HRAS
20 11.39 KRAS HRAS CDKN2A
21 11.37 KRAS HRAS
22 11.27 KRAS HRAS
23 11.21 KRAS HRAS
24 11.18 KRAS HRAS CDKN2A
25 11.15 KRAS HRAS
26 11.07 KRAS HRAS
27 11.01 KRAS HRAS
28 11 KRAS HRAS
29
Show member pathways
10.97 KRAS HRAS
30
Show member pathways
10.91 KRAS HRAS
31 10.84 KRAS HRAS
32 10.8 KRAS HRAS
33 10.73 KRAS HRAS
34 10.66 KRAS HRAS CDKN2A
35 10.44 KRAS HRAS

GO Terms for Trachea Carcinoma in Situ

Biological processes related to Trachea Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.61 KRAS HRAS CDKN2A
2 liver development GO:0001889 9.48 KRAS HRAS
3 regulation of protein stability GO:0031647 9.46 KRAS CDKN2A
4 positive regulation of MAP kinase activity GO:0043406 9.4 KRAS HRAS
5 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.37 HHEX CDKN2A
6 cellular senescence GO:0090398 9.32 HRAS CDKN2A
7 regulation of long-term neuronal synaptic plasticity GO:0048169 9.26 KRAS HRAS
8 positive regulation of cellular senescence GO:2000774 9.16 KRAS CDKN2A
9 response to isolation stress GO:0035900 8.96 KRAS HRAS
10 Ras protein signal transduction GO:0007265 8.8 KRAS HRAS CDKN2A

Molecular functions related to Trachea Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GDP binding GO:0019003 8.62 KRAS HRAS

Sources for Trachea Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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