MCID: TRC002
MIFTS: 30

Trachea Carcinoma in Situ

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Trachea Carcinoma in Situ

MalaCards integrated aliases for Trachea Carcinoma in Situ:

Name: Trachea Carcinoma in Situ 12 15
Carcinoma in Situ of Trachea 12 71
Tracheal Carcinoma in Situ 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8802
ICD9CM 34 231.1
NCIt 50 C3639
SNOMED-CT 67 92772005
ICD10 32 D02.1
UMLS 71 C0154070

Summaries for Trachea Carcinoma in Situ

Disease Ontology : 12 An in situ carcinoma that is located in the trachea.

MalaCards based summary : Trachea Carcinoma in Situ, also known as carcinoma in situ of trachea, is related to epithelial-myoepithelial carcinoma and myoepithelial carcinoma, and has symptoms including dyspnea, hemoptysis and coughing. An important gene associated with Trachea Carcinoma in Situ is KRT14 (Keratin 14), and among its related pathways/superpathways are G-Beta Gamma Signaling and Human cytomegalovirus infection. Affiliated tissues include trachea, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Trachea Carcinoma in Situ

Diseases in the Trachea Carcinoma family:

Trachea Carcinoma in Situ

Diseases related to Trachea Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 epithelial-myoepithelial carcinoma 10.1 KRT14 HRAS
2 myoepithelial carcinoma 10.1 KRT14 HRAS
3 ameloblastic carcinoma 10.0 KRT14 CDKN2A
4 spitz nevus 10.0 HRAS CDKN2A
5 adult malignant schwannoma 10.0 HRAS CDKN2A
6 spitzoid melanoma 10.0 HRAS CDKN2A
7 ischemic fasciitis 10.0 KRT14 CDKN2A
8 malignant spindle cell melanoma 10.0 HRAS CDKN2A
9 nasal cavity cancer 10.0 HRAS CDKN2A
10 prostate squamous cell carcinoma 10.0 HRAS CDKN2A
11 skin benign neoplasm 10.0 KRT14 HRAS
12 borst-jadassohn intraepidermal carcinoma 10.0 KRT14 CDKN2A
13 vulvar disease 10.0 HRAS CDKN2A
14 nodular malignant melanoma 10.0 HRAS CDKN2A
15 acral lentiginous melanoma 10.0 HRAS CDKN2A
16 basaloid squamous cell carcinoma 10.0 KRT14 CDKN2A
17 lip and oral cavity cancer 10.0 HRAS CDKN2A
18 tonsil cancer 10.0 KRT14 CDKN2A
19 vulva cancer 10.0 HRAS CDKN2A
20 melanoma in congenital melanocytic nevus 10.0 HRAS CDKN2A
21 skin squamous cell carcinoma 10.0 HRAS CDKN2A
22 actinic keratosis 10.0 HRAS CDKN2A
23 papillary adenoma 9.9 KRAS HRAS
24 hepatic flexure cancer 9.9 KRAS HRAS
25 signet ring basal cell carcinoma 9.9 KRAS HRAS
26 cobblestone retinal degeneration 9.9 KRAS HRAS
27 immature teratoma of ovary 9.9 KRAS HRAS
28 descending colon cancer 9.9 KRAS HRAS
29 ampulla of vater neoplasm 9.9 KRAS HRAS
30 transverse colon cancer 9.9 KRAS HRAS
31 periampullary adenoma 9.9 KRAS HRAS
32 acneiform dermatitis 9.9 KRAS HRAS
33 appendiceal neoplasm 9.9 KRAS HRAS
34 gallbladder benign neoplasm 9.9 KRAS HRAS
35 adenosquamous lung carcinoma 9.9 KRAS HRAS
36 appendix adenocarcinoma 9.9 KRAS HRAS
37 mucinous lung adenocarcinoma 9.9 KRAS HRAS
38 wolffian duct adenocarcinoma 9.9 KRAS HRAS
39 myh-associated polyposis 9.9 KRAS HRAS
40 noonan syndrome-like disorder with loose anagen hair 1 9.9 KRAS HRAS
41 noonan syndrome-like disorder with loose anagen hair 9.9 KRAS HRAS
42 ascending colon cancer 9.9 KRAS HRAS
43 biliary tract benign neoplasm 9.9 KRAS HRAS
44 ovarian mucinous neoplasm 9.9 KRAS HRAS
45 pancreatic acinar cell adenocarcinoma 9.9 KRAS HRAS
46 paronychia 9.9 KRAS HRAS
47 appendix disease 9.9 KRAS HRAS
48 bile duct cysts 9.9 KRAS HRAS
49 lung carcinoma in situ 9.9 KRAS HRAS
50 suppression of tumorigenicity 12 9.9 HRAS CDKN2A

Graphical network of the top 20 diseases related to Trachea Carcinoma in Situ:



Diseases related to Trachea Carcinoma in Situ

Symptoms & Phenotypes for Trachea Carcinoma in Situ

UMLS symptoms related to Trachea Carcinoma in Situ:


dyspnea, hemoptysis, coughing, hoarseness

GenomeRNAi Phenotypes related to Trachea Carcinoma in Situ according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.53 HRAS KRAS
2 Decreased viability GR00055-A-2 9.53 HRAS KRAS
3 Decreased viability GR00055-A-3 9.53 KRAS
4 Decreased viability GR00106-A-0 9.53 KRAS
5 Decreased viability GR00221-A-1 9.53 CDKN2A HRAS KRAS
6 Decreased viability GR00221-A-2 9.53 HRAS KRAS
7 Decreased viability GR00221-A-3 9.53 CDKN2A HRAS
8 Decreased viability GR00221-A-4 9.53 CDKN2A
9 Decreased viability GR00301-A 9.53 KRAS
10 Decreased viability GR00381-A-1 9.53 KRAS

MGI Mouse Phenotypes related to Trachea Carcinoma in Situ:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.67 CDKN2A HRAS KRAS KRT14
2 endocrine/exocrine gland MP:0005379 9.62 CDKN2A HRAS KRAS KRT14
3 integument MP:0010771 9.56 CDKN2A HRAS KRAS KRT14
4 neoplasm MP:0002006 9.46 CDKN2A HRAS KRAS KRT14
5 pigmentation MP:0001186 9.13 CDKN2A KRAS KRT14
6 respiratory system MP:0005388 8.92 CDKN2A HRAS KRAS KRT14

Drugs & Therapeutics for Trachea Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Trachea Carcinoma in Situ

Genetic Tests for Trachea Carcinoma in Situ

Anatomical Context for Trachea Carcinoma in Situ

The Foundational Model of Anatomy Ontology organs/tissues related to Trachea Carcinoma in Situ:

19
Trachea

MalaCards organs/tissues related to Trachea Carcinoma in Situ:

40
Trachea

Publications for Trachea Carcinoma in Situ

Variations for Trachea Carcinoma in Situ

Expression for Trachea Carcinoma in Situ

Search GEO for disease gene expression data for Trachea Carcinoma in Situ.

Pathways for Trachea Carcinoma in Situ

Pathways related to Trachea Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 KRAS HRAS CDKN2A
2
Show member pathways
12.64 KRAS HRAS CDKN2A
3
Show member pathways
12.6 KRAS HRAS CDKN2A
4
Show member pathways
12.56 KRAS HRAS CDKN2A
5 12.53 KRAS HRAS CDKN2A
6
Show member pathways
12.45 KRAS HRAS CDKN2A
7
Show member pathways
12.39 KRAS HRAS CDKN2A
8
Show member pathways
12.36 KRAS HRAS CDKN2A
9
Show member pathways
12.35 KRT14 KRAS HRAS
10 12.18 KRAS HRAS CDKN2A
11 11.92 KRAS HRAS CDKN2A
12 11.85 KRAS HRAS CDKN2A
13 11.76 KRAS HRAS
14 11.75 KRAS HRAS
15
Show member pathways
11.73 KRAS HRAS
16
Show member pathways
11.72 KRAS HRAS
17 11.71 HRAS CDKN2A
18 11.68 KRAS HRAS
19
Show member pathways
11.64 KRAS HRAS
20
Show member pathways
11.63 KRAS HRAS
21 11.63 KRAS HRAS CDKN2A
22 11.61 KRAS HRAS
23
Show member pathways
11.58 KRAS HRAS
24 11.52 KRAS HRAS
25 11.5 KRAS HRAS
26 11.48 KRAS HRAS
27
Show member pathways
11.45 KRAS HRAS
28 11.44 KRAS HRAS
29 11.4 KRAS HRAS
30 11.39 KRAS HRAS CDKN2A
31 11.37 KRAS HRAS
32 11.29 KRAS HRAS
33 11.23 KRAS HRAS
34 11.18 KRAS HRAS CDKN2A
35 11.15 KRAS HRAS
36 11.08 KRAS HRAS
37 11.02 KRAS HRAS
38 11.01 KRAS HRAS
39
Show member pathways
10.99 KRAS HRAS
40
Show member pathways
10.91 KRAS HRAS
41 10.84 KRAS HRAS
42 10.8 KRAS HRAS
43 10.73 KRAS HRAS
44 10.66 KRAS HRAS CDKN2A
45 10.44 KRAS HRAS

GO Terms for Trachea Carcinoma in Situ

Biological processes related to Trachea Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.54 KRAS HRAS CDKN2A
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.48 KRAS HRAS
3 regulation of protein stability GO:0031647 9.46 KRAS CDKN2A
4 liver development GO:0001889 9.43 KRAS HRAS
5 positive regulation of MAP kinase activity GO:0043406 9.4 KRAS HRAS
6 cellular senescence GO:0090398 9.32 HRAS CDKN2A
7 positive regulation of cellular senescence GO:2000774 9.26 KRAS CDKN2A
8 regulation of long-term neuronal synaptic plasticity GO:0048169 9.16 KRAS HRAS
9 response to isolation stress GO:0035900 8.96 KRAS HRAS
10 Ras protein signal transduction GO:0007265 8.8 KRAS HRAS CDKN2A

Molecular functions related to Trachea Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GDP binding GO:0019003 8.62 KRAS HRAS

Sources for Trachea Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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