MCID: TRC001
MIFTS: 30

Trachea Leiomyoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Trachea Leiomyoma

MalaCards integrated aliases for Trachea Leiomyoma:

Name: Trachea Leiomyoma 12 15
Tracheal Neoplasms 43 71
Leiomyoma of the Trachea 12
Tracheal Leiomyoma 71
Tracheal Neoplasm 17

Classifications:



External Ids:

Disease Ontology 12 DOID:248
MeSH 43 D014134
NCIt 49 C3419 C6049
UMLS 71 C0040582 C1336772

Summaries for Trachea Leiomyoma

Disease Ontology : 12 A respiratory system benign neoplasm that derives from smooth muscle cells and is located in the trachea.

MalaCards based summary : Trachea Leiomyoma, also known as tracheal neoplasms, is related to tracheal cancer and leiomyoma. An important gene associated with Trachea Leiomyoma is S100A10 (S100 Calcium Binding Protein A10), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and VEGF Pathway (Qiagen). The drugs Fluorouracil and Belinostat have been mentioned in the context of this disorder. Affiliated tissues include trachea, smooth muscle and lung, and related phenotype is integument.

Related Diseases for Trachea Leiomyoma

Diseases related to Trachea Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 19, show less)
# Related Disease Score Top Affiliating Genes
1 tracheal cancer 11.3
2 leiomyoma 10.5
3 47,xyy 10.0
4 papilloma 9.9
5 renal cell carcinoma, nonpapillary 9.8
6 hydrops, lactic acidosis, and sideroblastic anemia 9.8
7 adenoid cystic carcinoma 9.8
8 pulmonary edema 9.8
9 squamous cell papilloma 9.8
10 hemangioma 9.8
11 pleomorphic adenoma 9.8
12 adenoma 9.8
13 virus-associated trichodysplasia spinulosa 9.8
14 rare tumor 9.8
15 differentiated thyroid carcinoma 9.6 FN1 EGFR
16 gingival fibromatosis 9.5 FN1 EGFR
17 gliosarcoma 9.5 FN1 EGFR
18 suppression of tumorigenicity 12 9.4 FN1 EGFR
19 lung disease 9.2 FN1 EGFR

Graphical network of the top 20 diseases related to Trachea Leiomyoma:



Diseases related to Trachea Leiomyoma

Symptoms & Phenotypes for Trachea Leiomyoma

MGI Mouse Phenotypes related to Trachea Leiomyoma:

45 (showing 1, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 8.8 EGFR FN1 S100A10

Drugs & Therapeutics for Trachea Leiomyoma

Drugs for Trachea Leiomyoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 8, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 1 51-21-8 3385
2
Belinostat Approved, Investigational Phase 1 866323-14-0
3
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
4 Immunologic Factors Phase 1
5 Histone Deacetylase Inhibitors Phase 1
6 Antimetabolites Phase 1
7 Androgens Phase 1
8 Immunosuppressive Agents Phase 1

Interventional clinical trials:

(showing 2, show less)
# Name Status NCT ID Phase Drugs
1 Replacement of the Airways and/or the Pulmonary Vessels Using a Cryopreserved Arterial Allograft Unknown status NCT01331863 Phase 1, Phase 2
2 A Phase I Safety, Pharmacodynamic, Anti-Tumor Activity, and Pharmacokinetic Study of PXD101 Alone and in Combination With 5-Fluorouracil in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)

Search NIH Clinical Center for Trachea Leiomyoma

Cochrane evidence based reviews: tracheal neoplasms

Genetic Tests for Trachea Leiomyoma

Anatomical Context for Trachea Leiomyoma

The Foundational Model of Anatomy Ontology organs/tissues related to Trachea Leiomyoma:

19
Trachea

MalaCards organs/tissues related to Trachea Leiomyoma:

40
Trachea, Smooth Muscle, Lung, Thyroid

Publications for Trachea Leiomyoma

Articles related to Trachea Leiomyoma:

(showing 44, show less)
# Title Authors PMID Year
1
Programmed death ligand 1 and CD8+ immune cell infiltrates in resected primary tracheal malignant neoplasms. 61
30418532 2019
2
[Clinical application of high frequency jet ventilation in cryotherapy for tracheo-bronchial carcinoma via rigid bronchoscopy]. 61
29996287 2018
3
Tracheal cancer - treatment results, prognostic factors and incidence of other neoplasms. 61
27904449 2016
4
Tracheal resection and reconstruction for malignant disease. 61
26981265 2016
5
Autologous tracheal replacement for cancer. 61
26730758 2015
6
Anesthetic management for bronchoscopy and debulking of obstructing intratracheal tumor. 61
26543475 2015
7
Computed tomography correlation of airway disease with bronchoscopy--part II: tracheal neoplasms. 61
25088220 2014
8
Successful tracheal replacement in humans using autologous tissues: an 8-year experience. 61
23998399 2013
9
Autologous tracheal replacement: from research to clinical practice. 61
23993275 2013
10
The use of metallic expandable tracheal stents in the management of inoperable malignant tracheal obstruction. 61
21431955 2012
11
Tracheal stenosis and adenocarcinoma in an olive baboon (Papio cynocephalus anubis). 61
22330583 2011
12
[Experience with the treatment of juvenile respiratory papillomatosis in childhood]. 61
22433698 2011
13
[Diagnosis and surgery of primary tracheal neoplasms in children]. 61
19558846 2009
14
Tracheal spindle cell tumor in a child. 61
14703113 2003
15
Adenoid cystic carcinoma of the trachea and bronchus--a clinicopathologic study with DNA flow cytometric analysis and oncogene expression. 61
12297183 2002
16
Tracheal reconstruction with free composite cartilage graft: a case report. 61
12422086 2002
17
Contemporary role of modern brachytherapy techniques in the management of malignant thoracic tumors. 61
11291133 2001
18
[Pleomorphic adenoma: a case treated by laryngotracheal resection and reconstruction]. 61
10885156 2000
19
Treatment of primary tracheal carcinoma. The role of external and endoluminal radiotherapy. 61
10650832 2000
20
HDR-brachytherapy boost for residual tumour after external beam radiotherapy in patients with tracheal malignancies. 61
10580872 1999
21
Mucoepidermoid carcinoma of the trachea in a child. 61
9865444 1998
22
Tracheal neoplasms in children. 61
9749550 1998
23
Adenoid cystic carcinoma of the trachea. 61
9738744 1998
24
Tracheal chondrosarcoma: a case report. 61
9702546 1998
25
Management of Tracheal Neoplasms. 61
10388056 1997
26
Management of Tracheal Neoplasms. 61
10388015 1996
27
The trachea: pathologic conditions and trauma. 61
8504326 1993
28
Primary tracheal neoplasms: recognition, diagnosis and evaluation. 61
1595514 1992
29
[Malignant tracheal tumor--differential diagnosis in bronchial asthma]. 61
1665599 1991
30
Tracheal infiltration causing stridor: a rare presentation of stage I Hodgkin's disease. 61
2102190 1990
31
Kaposi's sarcoma of the trachea. 61
3199020 1988
32
[Endoscopic semeiotics of tracheal neoplasms]. 61
2850397 1988
33
Primary malignant tracheal neoplasms: case reports and literature radiotherapy review. 61
2429118 1986
34
One hundred neodymium-YAG laser ablations of obstructing tracheal neoplasms. 61
6486952 1984
35
Intratracheal neurofibroma. 61
6410518 1983
36
Primary tracheal neoplasms. 61
6086509 1983
37
Computed tomography of the trachea: normal and abnormal. 61
6979885 1982
38
[Primary carcinoma of the trachea (author's transl)]. 61
7382622 1980
39
Endotracheal irradiation of adenoid cystic carcinoma of the trachea. 61
208100 1978
40
[Benign tracheal neoplasms]. 61
5422699 1970
41
The management of malignant tracheal neoplasms. 61
4317429 1970
42
[Unusual benign tumors of the trachea. Leiomyoma, intratracheal struma]. 61
4297731 1966
43
Tracheal neoplasms presenting with mediastinal emphysema. 61
14025084 1962
44
[Trials of intubation in the therapy of inoperable tracheal neoplasms]. 61
14468157 1962

Variations for Trachea Leiomyoma

Expression for Trachea Leiomyoma

Search GEO for disease gene expression data for Trachea Leiomyoma.

Pathways for Trachea Leiomyoma

Pathways related to Trachea Leiomyoma according to GeneCards Suite gene sharing:

(showing 6, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.9 FN1 EGFR
2
Show member pathways
11.69 FN1 EGFR
3 11.57 FN1 EGFR
4
Show member pathways
11.41 FN1 EGFR
5 10.79 FN1 EGFR
6 10.41 FN1 EGFR

GO Terms for Trachea Leiomyoma

Cellular components related to Trachea Leiomyoma according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.96 FN1 EGFR
2 membrane raft GO:0045121 8.62 S100A10 EGFR

Biological processes related to Trachea Leiomyoma according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 wound healing GO:0042060 9.16 FN1 EGFR
2 positive regulation of fibroblast proliferation GO:0048146 8.96 FN1 EGFR
3 regulation of ERK1 and ERK2 cascade GO:0070372 8.62 FN1 EGFR

Molecular functions related to Trachea Leiomyoma according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 8.62 FN1 EGFR

Sources for Trachea Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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