MCID: TRC016
MIFTS: 25

Tracheal Calcification

Categories: Respiratory diseases

Aliases & Classifications for Tracheal Calcification

MalaCards integrated aliases for Tracheal Calcification:

Name: Tracheal Calcification 12 15
Calcification of Trachea 12 70

Classifications:



External Ids:

Disease Ontology 12 DOID:14224
NCIt 50 C35314
SNOMED-CT 67 81089005
UMLS 70 C0264324

Summaries for Tracheal Calcification

MalaCards based summary : Tracheal Calcification, also known as calcification of trachea, is related to conjunctival deposit and hepatocellular clear cell carcinoma. An important gene associated with Tracheal Calcification is ARSL (Arylsulfatase L), and among its related pathways/superpathways are Parathyroid hormone synthesis, secretion and action and Warfarin Pathway, Pharmacodynamics. Affiliated tissues include trachea, kidney and bone, and related phenotype is limbs/digits/tail.

Related Diseases for Tracheal Calcification

Diseases related to Tracheal Calcification via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 conjunctival deposit 10.2 KL FGF23
2 hepatocellular clear cell carcinoma 10.2 KL FGF23
3 familial tumoral calcinosis 10.2 KL FGF23
4 hyperlipoproteinemia, type v 10.2 KL FGF23
5 osteoglophonic dysplasia 10.2 KL FGF23
6 skin atrophy 10.2 KL FGF23
7 angioid streaks 10.1 MGP AHSG
8 chronic mountain sickness 10.0 NPPB EPO
9 hemangiopericytoma, malignant 10.0 MUC1 FGF23
10 diffuse alveolar hemorrhage 10.0 MUC1 CYP2C9
11 benign giant cell tumor 10.0 MUC1 FGF23
12 oncogenic osteomalacia 10.0 PTH FGF23
13 uremic neuropathy 9.9 PTH EPO
14 osteitis fibrosa 9.9 PTH FGF23
15 spondylosis 9.9 PTH KL
16 renal hypertension 9.9 NPPB EPO
17 periventricular leukomalacia 9.9 NPPB EPO
18 hypophosphatasia 9.9 PTH FGF23
19 nephrolithiasis/osteoporosis, hypophosphatemic, 1 9.8 PTH KL FGF23
20 hypervitaminosis d 9.8 PTH KL FGF23
21 chondrodysplasia punctata, autosomal dominant 9.8
22 chondrodysplasia punctata syndrome 9.8
23 dental abscess 9.8 PTH KL FGF23
24 hypophosphatemic rickets with hypercalciuria, hereditary 9.8 PTH KL FGF23
25 rickets 9.8 PTH KL FGF23
26 enthesopathy 9.8 PTH KL FGF23
27 metaphyseal chondrodysplasia, jansen type 9.8 PTH KL FGF23
28 arterial calcification of infancy 9.8 MGP KL FGF23 AHSG
29 hypophosphatemic rickets, autosomal dominant 9.8 PTH KL FGF23
30 autosomal recessive hypophosphatemic rickets 9.8 PTH KL FGF23
31 calcinosis 9.8 MGP KL FGF23 AHSG
32 tumoral calcinosis, hyperphosphatemic, familial, 1 9.8 PTH KL FGF23
33 hypophosphatemia 9.8 PTH KL FGF23
34 bone remodeling disease 9.8 PTH KL FGF23
35 hypophosphatemic rickets, x-linked dominant 9.8 PTH KL FGF23
36 polycystic kidney disease 9.8 KL FGF23 EPO AHSG
37 pulmonary artery disease 9.8 NPPB F10 CYP2C9
38 renal osteodystrophy 9.7 PTH MGP FGF23
39 nephrolithiasis 9.7 PTH FGF23 AHSG
40 autosomal dominant polycystic kidney disease 9.7 KL FGF23 AHSG
41 mammary paget's disease 9.7 PTH MUC1
42 parathyroid gland disease 9.7 PTH KL FGF23 EPO
43 secondary hyperparathyroidism 9.7 PTH KL FGF23 EPO
44 heart conduction disease 9.7 NPPB F10 CYP2C9
45 hyperparathyroidism 9.7 PTH KL FGF23 EPO
46 hyperphosphatemia 9.6 PTH MGP KL FGF23
47 primary hyperparathyroidism 9.6 PTH KL FGF23 AHSG
48 uremia 9.5 PTH MGP EPO AHSG
49 bone disease 9.4 PTH FGF23 EPO
50 phosphorus metabolism disease 9.4 PTH MGP KL FGF23 AHSG

Graphical network of the top 20 diseases related to Tracheal Calcification:



Diseases related to Tracheal Calcification

Symptoms & Phenotypes for Tracheal Calcification

MGI Mouse Phenotypes related to Tracheal Calcification:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.02 AHSG EPO FGF23 KL PTH

Drugs & Therapeutics for Tracheal Calcification

Search Clinical Trials , NIH Clinical Center for Tracheal Calcification

Genetic Tests for Tracheal Calcification

Anatomical Context for Tracheal Calcification

MalaCards organs/tissues related to Tracheal Calcification:

40
Trachea, Kidney, Bone, Heart, Skin

Publications for Tracheal Calcification

Articles related to Tracheal Calcification:

(show all 13)
# Title Authors PMID Year
1
Does the computed tomographic appearance of the lung differ between young and old dogs? 61
28758345 2017
2
Sarcoidosis Presenting with Tracheobronchial Calcification and Nodularity: An Unusual Case Presentation with Treatment Response Assessment by 18F-FDG-PET/CT. 61
28680208 2017
3
Chondrodysplasia punctata presenting with tracheal obstruction. 61
28109478 2017
4
Diagnostic accuracy and added value of dual-energy subtraction radiography compared to standard conventional radiography using computed tomography as standard of reference. 61
28301584 2017
5
Partial Reversal of Tissue Calcification and Extension of Life Span following Ammonium Nitrate Treatment of Klotho-Deficient Mice. 61
26881935 2016
6
Senile Calcification of the Trachea, Aortic Arch, and Mitral Annulus: An Incidental Finding on Chest X-Ray. 61
26985213 2015
7
Tracheal calcification. 61
18663210 2008
8
[A case of the metastatic calcification of trachea, bronchus, and lung]. 61
17929478 2007
9
[Thoracic imaging in the elderly]. 61
9441175 1997
10
Tracheobronchial calcification: an observation in three children after mitral valve replacement and warfarin sodium therapy. 61
2389031 1990
11
Calcification of the intrathoracic trachea demonstrated by computed tomography. 61
2306585 1990
12
[Autosomal dominant chondrodysplasia punctata with laryngo-tracheal calcification. Presentation of 2 cases]. 61
3842991 1985
13
Lethal chondrodysplasia punctata. 61
737958 1978

Variations for Tracheal Calcification

Expression for Tracheal Calcification

Search GEO for disease gene expression data for Tracheal Calcification.

Pathways for Tracheal Calcification

Pathways related to Tracheal Calcification according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.82 PTH KL FGF23
2 10.33 MGP F10
3 10.1 PTH FGF23

GO Terms for Tracheal Calcification

Cellular components related to Tracheal Calcification according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 PTH NPPB MUC1 KL FGF23 F10
2 endoplasmic reticulum lumen GO:0005788 9.46 FGF23 F10 ARSL AHSG
3 Golgi lumen GO:0005796 9.43 MUC1 FGF23 F10
4 extracellular region GO:0005576 9.32 PTH NPPB MUC1 MGP KL FGF23

Biological processes related to Tracheal Calcification according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.54 PTH ARSL AHSG
2 acute-phase response GO:0006953 9.46 EPO AHSG
3 positive regulation of bone mineralization GO:0030501 9.43 PTH KL
4 calcium ion homeostasis GO:0055074 9.4 PTH KL
5 negative regulation of bone mineralization GO:0030502 9.32 FGF23 AHSG
6 phosphate ion homeostasis GO:0055062 9.26 PTH FGF23
7 positive regulation of protein kinase B signaling GO:0051897 9.26 KL FGF23 F10 EREG
8 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.16 KL FGF23
9 regulation of bone mineralization GO:0030500 8.8 MGP FGF23 AHSG

Molecular functions related to Tracheal Calcification according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor receptor binding GO:0005104 8.96 KL FGF23
2 hormone activity GO:0005179 8.92 PTH NPPB KL EPO

Sources for Tracheal Calcification

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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