MCID: TRC025
MIFTS: 33

Tracheal Cancer

Categories: Cancer diseases, Respiratory diseases
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Aliases & Classifications for Tracheal Cancer

MalaCards integrated aliases for Tracheal Cancer:

Name: Tracheal Cancer 11 14 36
Malignant Neoplasm of Trachea 71 31
Tracheal Carcinoma 16 71
Pulmonary Sulcus Neoplasm 71
Tracheal Neoplasms 71
Pancoast Syndrome 71
Pancoast Tumor 71

Classifications:



External Ids:

Disease Ontology 11 DOID:11920
ICD9CM 34 162.0
NCIt 49 C9346
SNOMED-CT 68 187855003
ICD10 31 C33
UMLS 71 C0030271 C0040582 C0153489 more

Summaries for Tracheal Cancer

Disease Ontology: 11 A respiratory system cancer that is located in the trachea.

MalaCards based summary: Tracheal Cancer, also known as malignant neoplasm of trachea, is related to trachea carcinoma and small cell carcinoma. An important gene associated with Tracheal Cancer is LPAR3 (Lysophosphatidic Acid Receptor 3). The drugs Cisplatin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include trachea, bone marrow and lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Tracheal Cancer

Diseases related to Tracheal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 trachea carcinoma 31.4 PLEKHH3 LPAR3 KRT5 ALPI
2 small cell carcinoma 29.7 SYP KRT5
3 trachea carcinoma in situ 11.3
4 adenoid cystic carcinoma 10.1
5 thymus basaloid carcinoma 10.1 SYP KRT5
6 cloacogenic carcinoma 10.1 SYP KRT5
7 rectum squamous cell carcinoma 10.1 SYP KRT5
8 middle ear adenoma 10.1 SYP KRT5
9 auditory system benign neoplasm 10.1 SYP KRT5
10 papillary squamous carcinoma 10.1 SYP KRT5
11 breast papillary carcinoma 10.1 SYP KRT5
12 vulva basal cell carcinoma 10.0 SYP KRT5
13 ureter small cell carcinoma 10.0 SYP KRT5
14 sensory organ benign neoplasm 10.0 SYP KRT5
15 sinonasal undifferentiated carcinoma 10.0 SYP KRT5
16 thymus large cell carcinoma 10.0 SYP KRT5
17 large cell carcinoma 10.0 SYP KRT5
18 nasal cavity olfactory neuroblastoma 10.0 SYP KRT5
19 cystic basal cell carcinoma 10.0 SYP KRT5
20 prostate signet ring cell adenocarcinoma 10.0 SYP KRT5
21 papillary adenoma 10.0 SYP KRT5
22 squamous cell carcinoma 10.0
23 central epithelioid sarcoma 10.0 SYP KRT5
24 vulvar proximal-type epithelioid sarcoma 10.0 SYP KRT5
25 lymphoepithelioma-like carcinoma 10.0 SYP KRT5
26 basaloid squamous cell carcinoma 10.0 SYP KRT5
27 anus basaloid carcinoma 10.0 SYP KRT5
28 laryngeal small cell carcinoma 10.0 SYP KRT5
29 esophageal neuroendocrine tumor 10.0 SYP KRT5
30 keratinizing squamous cell carcinoma 10.0 SYP KRT5
31 mediastinal cancer 10.0 SYP KRT5
32 cystic teratoma 10.0 SYP KRT5
33 endobronchial lipoma 10.0 SYP KRT5
34 paranasal sinus cancer 10.0 SYP KRT5
35 large cell neuroendocrine carcinoma 10.0 SYP KRT5
36 nasal cavity cancer 9.9 SYP KRT5
37 lung large cell carcinoma 9.9 SYP KRT5
38 malignant iris melanoma 9.9 TMEM14C ENTREP3
39 respiratory system benign neoplasm 9.9 SYP KRT5
40 sweat gland cancer 9.9 SYP KRT5
41 mixed cell type cancer 9.9 SYP KRT5
42 benign teratoma 9.8 SYP KRT5
43 thymic carcinoma 9.8 SYP KRT5
44 lung cancer 9.8
45 ceroid lipofuscinosis, neuronal, 5 9.8
46 pneumoconiosis 9.8
47 anthracosis 9.8
48 respiratory failure 9.8
49 trachea squamous cell carcinoma 9.8
50 hypothyroidism 9.8

Graphical network of the top 20 diseases related to Tracheal Cancer:



Diseases related to Tracheal Cancer

Symptoms & Phenotypes for Tracheal Cancer

GenomeRNAi Phenotypes related to Tracheal Cancer according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.32 LPAR3
2 Decreased viability GR00055-A-2 9.32 LPAR3
3 Decreased viability GR00249-S 9.32 LPAR3
4 Decreased viability GR00381-A-1 9.32 LPAR3 TMEM14C
5 Decreased viability GR00381-A-2 9.32 LPAR3 TMEM14C
6 Decreased viability GR00381-A-3 9.32 LPAR3
7 Decreased viability GR00386-A-1 9.32 TMEM14C
8 Decreased viability GR00402-S-2 9.32 TMEM14C

Drugs & Therapeutics for Tracheal Cancer

Drugs for Tracheal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 2767 5702198 441203
2
Etoposide Approved Phase 2 33419-42-0 36462
3
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
4
Vindesine Approved, Investigational Phase 2 59917-39-4, 53643-48-4 40839
5
Nivolumab Approved Phase 2 946414-94-4
6
Ipilimumab Approved Phase 2 477202-00-9
7 Tubulin Modulators Phase 2
8
Etoposide phosphate Phase 2 16760419
9 Antimitotic Agents Phase 2
10 Mitomycins Phase 2
11 Antibiotics, Antitubercular Phase 2
12 Anti-Bacterial Agents Phase 2
13 Alkylating Agents Phase 2
14 Antineoplastic Agents, Immunological Phase 2
15 Antibodies, Monoclonal Phase 2
16 Antibodies Phase 2
17 Immunoglobulins Phase 2
18 Immune Checkpoint Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Replacement of the Airways and/or the Pulmonary Vessels Using a Cryopreserved Arterial Allograft Completed NCT01331863 Phase 1, Phase 2
2 A Phase II Trial of Induction Chemoradiotherapy With Cisplatin/Etoposide Followed by Surgical Resection, Followed by Docetaxel, for Non-Small Cell Lung Cancer Involving the Superior Sulcus (Pancoast Tumors) Completed NCT00062439 Phase 2 cisplatin;docetaxel;etoposide
3 A Phase II Trial of Pre-operative Chemoradiotherapy Followed by Surgical Resection in Pancoast Tumors: Initial Report of Japan Clinical Oncology Group Trial (JCOG 9806) Completed NCT00128037 Phase 2 mitomycin C, vindesine, cisplatin and radiotherapy
4 DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Recruiting NCT02834013 Phase 2

Search NIH Clinical Center for Tracheal Cancer

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Tracheal Cancer cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Tracheal Cancer:
InBreath System, a nanofiber scaffold seeded with mononuclear cells for tracheal injuries
Embryonic/Adult Cultured Cells Related to Tracheal Cancer:
Bone marrow-derived mononuclear cells (family)

Genetic Tests for Tracheal Cancer

Anatomical Context for Tracheal Cancer

Organs/tissues related to Tracheal Cancer:

FMA: Trachea
MalaCards : Trachea, Bone Marrow, Lung, Bone, Thyroid, Brain

Publications for Tracheal Cancer

Articles related to Tracheal Cancer:

(show top 50) (show all 179)
# Title Authors PMID Year
1
Association between polycyclic aromatic hydrocarbons (PAH) dietary exposure and mortality risk in the E3N cohort. 62
35697224 2022
2
Clinical experience of transbronchoscopic laser ablation for central airway stenosis using a high-power diode laser-ten years' experience at a single institute. 62
35016516 2022
3
Clinical characteristics, surgical treatments, prognosis, and prognostic factors of primary tracheal cancer patients: 20-year data of the National Cancer Center, China. 62
35693280 2022
4
Do We Need TNM for Tracheal Cancers? Analysis of a Large Retrospective Series of Tracheal Tumors. 62
35406437 2022
5
Which ICD-9 codes were assigned for malignant mesothelioma in the mortality data in the United States before the ICD-10 was introduced? 62
34779537 2022
6
[Surgery of primary tracheal tumors]. 62
35920218 2022
7
Anesthetic Management of Upper Tracheal Cancer Resection and Reconstruction: A Case Report. 62
36046034 2022
8
Radiotherapy for Primary Tracheal Carcinoma: Experience at a Single Institution. 62
34372715 2021
9
Healing, surviving, or dying? - projecting the German future disease burden using a Markov illness-death model. 62
33430836 2021
10
National Utilization of Surgery and Outcomes for Primary Tracheal Cancer in the United States. 62
32335015 2020
11
Clinical features and prognosis of primary tracheal small cell carcinoma: a population-based analysis. 62
35117433 2020
12
Cancer incidence and mortality trends in young adults in Metropolitan Lima young adults, 1990-2012. 62
32346391 2020
13
Effects of adjuvant radiation therapy on survival for patients with resected primary tracheal carcinoma: an analysis of the National Cancer Database. 62
30977818 2019
14
Complete Tumor Response of Tracheal Squamous Cell Carcinoma After Treatment With Pembrolizumab. 62
30326234 2019
15
Competing risk analysis of primary tracheal carcinoma based on SEER database. 62
30774433 2019
16
Clinical Characteristics and Prognosis of Primary Tracheal Cancer: A Single Institution Experience. 62
30774830 2018
17
Primary Tracheal Carcinoma. 62
29659419 2018
18
Rare case of radiation-induced primary tracheal carcinoma. 62
29546552 2018
19
Management of Malignant Tracheoesophageal Fistula. 62
30054077 2018
20
Tracheal segmental resection for tracheal cancer: comparison of cervical collar incision with median sternotomy and posterolateral incision. 62
30093998 2018
21
Survival trends in patients with tracheal carcinoma from 1973 to 2011. 62
28927948 2017
22
Successful one-lung ventilation using a bronchial blocker tube for a large tracheal carcinoma resection. 62
28494897 2017
23
Invasive tracheal neoplasia in eight cats: descriptive cases and review of the current literature. 62
35145722 2017
24
Tracheal cancer - treatment results, prognostic factors and incidence of other neoplasms. 62
27904449 2016
25
Marital status is an independent prognostic factor for tracheal cancer patients: an analysis of the SEER database. 62
27780931 2016
26
Dose reconstruction technique using non-rigid registration to evaluate spatial correspondence between high-dose region and late radiation toxicity: a case of tracheobronchial stenosis after external beam radiotherapy combined with endotracheal brachytherapy for tracheal cancer. 62
27257421 2016
27
Diseases Neglected by the Media in Espírito Santo, Brazil in 2011-2012. 62
27115486 2016
28
Resected Tracheal Adenoid Cystic Carcinoma: Improvements in Outcome at a Single Institution. 62
26431923 2016
29
Malignant tracheal tumors: a review of current diagnostic and management strategies. 62
25978628 2015
30
Treatment of tracheal mucoepidermoid carcinoma by argon plasma coagulation during pregnancy. 62
26011218 2015
31
Sequential stenting for extensive malignant airway stenosis. 62
25273272 2015
32
Patient-specific carbon nanocomposite tracheal prosthesis. 62
25633892 2015
33
Intractable obstructive endobronchial granulation caused by surgical materials after sleeve resection for tracheal carcinoma. 62
25468088 2014
34
Treatment approaches to primary tracheal cancer. 62
24295662 2014
35
Pathology of tracheal tumors. 62
24295655 2014
36
Management and prognosis of primary tracheal cancer: a national analysis. 62
23868448 2014
37
Characterization of stem-like cells in mucoepidermoid tracheal paediatric tumor. 62
25229469 2014
38
Health impact of the exposure to fibres with fluoro-edenitic composition on the residents in Biancavilla (Sicily, Italy): mortality and hospitalization from current data. 62
24968910 2014
39
Diagnosis of laryngotracheal stenosis from routine pulmonary physiology using the expiratory disproportion index. 62
23686716 2013
40
Successful treatment of a tracheal squamous cell carcinoma with a combination of cryoablation and photodynamic therapy. 62
28920198 2013
41
Tracheal replacement for primary tracheal cancer. 62
23385784 2013
42
The left thoracotomy approach for excision of distal tracheal carcinoma in the presence of right-sided aorta. 62
23315182 2013
43
Photodynamic therapy (PDT) may provide effective palliation in the treatment of primary tracheal carcinoma: a small case series. 62
23003123 2012
44
The use of radiation therapy appears to improve outcome in patients with malignant primary tracheal tumors: a SEER-based analysis. 62
22365629 2012
45
Scots Pine (Pinus sylvestris L.) Growth Suppression and Adverse Effects on Human Health Due to Air Pollution in the Upper Silesian Industrial District (USID), Southern Poland. 62
22707804 2012
46
Bioartificial tracheobronchial transplantation. Interview with Paolo Macchiarini. 62
21999257 2011
47
Primary tracheal adenocystic carcinoma and tracheal tumors during pregnancy. 62
22066040 2011
48
Population based cancer registry analysis of primary tracheal carcinoma. 62
20087156 2011
49
Tracheal cancer treated with a short course of external and endoluminal radio-chemotherapy combined with cetuximab - a case report. 62
27853478 2010
50
A primary squamous cell carcinoma of the trachea: case report and review of the literature. 62
21253287 2010

Variations for Tracheal Cancer

Expression for Tracheal Cancer

Search GEO for disease gene expression data for Tracheal Cancer.

Pathways for Tracheal Cancer

GO Terms for Tracheal Cancer

Sources for Tracheal Cancer

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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