MCID: TRC025
MIFTS: 42

Tracheal Cancer

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Tracheal Cancer

MalaCards integrated aliases for Tracheal Cancer:

Name: Tracheal Cancer 38 12 15
Pancoast Tumor 12 15 73
Malignant Neoplasm of Trachea 12 73
Trachea Carcinoma 12 15
Pancoast Syndrome 44 73
Superior Pulmonary Sulcus Syndrome 12
Malignant Superior Sulcus Tumor 12
Malignant Tumor of Trachea 12
Pulmonary Sulcus Neoplasm 73
Malignant Tracheal Tumor 12
Carcinoma of the Trachea 12
Pulmonary Sulcus Tumor 12
Pancoast's Syndrome 12
Tracheal Neoplasms 73
Tracheal Carcinoma 73
Tracheal Neoplasm 12
Pancoast's Tumour 12
Pancoast's Tumor 12
Ca Trachea 12

Classifications:



Summaries for Tracheal Cancer

Disease Ontology : 12 A respiratory system cancer that is located in the trachea.

MalaCards based summary : Tracheal Cancer, also known as pancoast tumor, is related to trachea leiomyoma and lung oat cell carcinoma. An important gene associated with Tracheal Cancer is SMUG1 (Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1), and among its related pathways/superpathways is NF-kappaB Signaling. The drugs Nivolumab and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include trachea, bone and lung, and related phenotypes are Reduced mammosphere formation and mortality/aging

Related Diseases for Tracheal Cancer

Diseases related to Tracheal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 trachea leiomyoma 32.9 SMUG1 TOP2A
2 lung oat cell carcinoma 30.7 AVP ENO2
3 small cell cancer of the lung 29.8 AVP CEACAM5 ENO2 GRP
4 trachea carcinoma in situ 12.2
5 trachea sarcoma 11.2
6 trachea mucoepidermoid carcinoma 11.1
7 adenoid cystic carcinoma 10.5
8 mucoepidermoid carcinoma 10.3
9 extragonadal nonseminomatous germ cell tumor 10.3 AFP SMUG1
10 sternum cancer 10.3 AFP SMUG1
11 corpus luteum cyst 10.3 AFP SMUG1
12 bladder calculus 10.3 PGRMC1 SMUG1
13 extragonadal germ cell cancer 10.3 AFP SMUG1
14 rectum squamous cell carcinoma 10.3 SMUG1 TNFRSF1B
15 gallbladder small cell carcinoma 10.3 ENO2 SMUG1
16 choriocarcinoma of ovary 10.2 ENO2 SRY
17 tuberculous epididymitis 10.2 AFP AVP
18 malignant sertoli cell tumor 10.2 AFP ENO2
19 rheumatoid lung disease 10.2 SMUG1 TNFRSF1B
20 mediastinal cancer 10.2 AFP SMUG1
21 klatskin's tumor 10.2 PGRMC1 SMUG1
22 rectosigmoid junction neoplasm 10.2 CTSL SMUG1
23 central nervous system germ cell tumor 10.2 AFP AVP
24 secondary hypertrophic osteoarthropathy 10.2 AVP SMUG1
25 mandibular cancer 10.2 CTSL SMUG1
26 chondromalacia 10.2 SMUG1 TNFRSF1B
27 sphenoid sinusitis 10.2 AVP PGRMC1
28 granulomatous myositis 10.2 SMUG1 TNFRSF1B
29 mature teratoma 10.2 AFP SMUG1
30 bronchus cancer 10.2 AVP ENO2
31 supraglottis cancer 10.2 ENO2 PGRMC1
32 endometrial small cell carcinoma 10.2 AFP ENO2
33 oculomotor nerve paralysis 10.2 AFP AVP SMUG1
34 olfactory nerve neoplasm 10.2 AVP ENO2
35 third cranial nerve disease 10.2 AFP AVP SMUG1
36 urinary bladder small cell neuroendocrine carcinoma 10.2 ENO2 GRP
37 lung meningioma 10.2 ENO2 GRP
38 gallbladder squamous cell carcinoma 10.2 CEACAM5 SMUG1
39 malignant acrospiroma 10.2 CEACAM5 SMUG1
40 anal canal adenocarcinoma 10.2 SLC5A7 TNFRSF1B
41 malignant spiradenoma 10.2 CEACAM5 SMUG1
42 dysgerminoma 10.1 AFP ENO2 SRY
43 lung cancer 10.1
44 brain germinoma 10.1 AFP AVP SLC5A7
45 tolosa-hunt syndrome 10.1 CEACAM5 SMUG1
46 anus adenocarcinoma 10.1 CEACAM5 SLC5A7
47 bladder neck obstruction 10.1 AFP TNFRSF1B
48 mucinous cystadenofibroma 10.1 AFP CEACAM5
49 cervix endometriosis 10.1 CEACAM5 TOP2A
50 squamous cell carcinoma 10.1

Graphical network of the top 20 diseases related to Tracheal Cancer:



Diseases related to Tracheal Cancer

Symptoms & Phenotypes for Tracheal Cancer

GenomeRNAi Phenotypes related to Tracheal Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 AFP CTSL EEF2 NR4A1 SRY TNFRSF1B

MGI Mouse Phenotypes related to Tracheal Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.36 AFP AVP CREB3L2 EEF2 MYB NR4A1

Drugs & Therapeutics for Tracheal Cancer

Drugs for Tracheal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 2 946414-94-4
2 Immunoglobulins Phase 2
3 Antibodies, Monoclonal Phase 2
4 Antibodies Phase 2
5 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2

Search NIH Clinical Center for Tracheal Cancer

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Tracheal Cancer cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Tracheal Cancer:
InBreath System, a nanofiber scaffold seeded with mononuclear cells for tracheal injuries
Embryonic/Adult Cultured Cells Related to Tracheal Cancer:
Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: pancoast syndrome

Genetic Tests for Tracheal Cancer

Anatomical Context for Tracheal Cancer

MalaCards organs/tissues related to Tracheal Cancer:

41
Trachea, Bone, Lung, Liver, Ovary, Cervix, Testis

The Foundational Model of Anatomy Ontology organs/tissues related to Tracheal Cancer:

19
The Trachea

Publications for Tracheal Cancer

Articles related to Tracheal Cancer:

(show all 17)
# Title Authors Year
1
Tracheal segmental resection for tracheal cancer: comparison of cervical collar incision with median sternotomy and posterolateral incision. ( 30093998 )
2018
2
Robotic Hybrid Approach for an Anterior Pancoast Tumor in a Severely Obese Patient. ( 29654726 )
2018
3
Primary Lung Signet Ring Cell Carcinoma Presenting as a Cavitary Pancoast Tumor in a 32-Year-Old Man. ( 29800025 )
2018
4
Marital status is an independent prognostic factor for tracheal cancer patients: an analysis of the SEER database. ( 27780931 )
2016
5
Dose reconstruction technique using non-rigid registration to evaluate spatial correspondence between high-dose region and late radiation toxicity: a case of tracheobronchial stenosis after external beam radiotherapy combined with endotracheal brachytherapy for tracheal cancer. ( 27257421 )
2016
6
Tracheal cancer - treatment results, prognostic factors and incidence of other neoplasms. ( 27904449 )
2016
7
Extracorporeal Lung Support as a Bridge to Airway Stenting and Radiotherapy for Airway-Obstructing Pancoast Tumor. ( 27343540 )
2016
8
Management and prognosis of primary tracheal cancer: A national analysis. ( 23868448 )
2014
9
Treatment approaches to primary tracheal cancer. ( 24295662 )
2014
10
Tracheal replacement for primary tracheal cancer. ( 23385784 )
2013
11
Hepatoid pancoast tumor. A case report and review of the literature. ( 22677427 )
2012
12
Tracheal cancer: Role of radiation therapy. ( 24376936 )
2010
13
Tracheal cancer treated with a short course of external and endoluminal radio-chemotherapy combined with cetuximab - a case report. ( 27853478 )
2010
14
Incidence and treatment of tracheal cancer: a nationwide study in the Netherlands. ( 17139460 )
2007
15
Clinicopathological investigation of 20 cases of primary tracheal cancer. ( 12493495 )
2003
16
Tracheal cancer in Denmark: a nationwide study. ( 11251276 )
2001
17
A case report of primary tracheal cancer from leprosy autopsy series with a review of the literature. ( 6520059 )
1984

Variations for Tracheal Cancer

Expression for Tracheal Cancer

Search GEO for disease gene expression data for Tracheal Cancer.

Pathways for Tracheal Cancer

Pathways related to Tracheal Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 CEACAM5 MYB NR4A1 TNFRSF1B

GO Terms for Tracheal Cancer

Cellular components related to Tracheal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 8.92 ENO2 PGRMC1 SLC5A7 TNFRSF1B

Biological processes related to Tracheal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.02 CREB3L2 MYB NELFCD NR4A1 SRY

Molecular functions related to Tracheal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 8.92 CREB3L2 MYB NR4A1 SRY

Sources for Tracheal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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