Aliases & Classifications for Tracheal Disease

MalaCards integrated aliases for Tracheal Disease:

Name: Tracheal Disease 38 12 15
Tracheal Diseases 44 73
Tracheal Disorders 43


External Ids:

Disease Ontology 12 DOID:3225
ICD10 33 S12.8
MeSH 44 D014133
NCIt 50 C35079
SNOMED-CT 68 47125007
UMLS 73 C0040580

Summaries for Tracheal Disease

MedlinePlus : 43 Your trachea, or windpipe, is one part of your airway system. Airways are pipes that carry oxygen-rich air to your lungs. They also carry carbon dioxide, a waste gas, out of your lungs. When you inhale, air travels from your nose, through your larynx, and down your windpipe. The windpipe splits into two bronchi that enter your lungs. Problems with the trachea include narrowing, inflammation, and some inherited conditions. You may need a procedure called a tracheostomy to help you breathe if you have swallowing problems, or have conditions that affect coughing or block your airways. You might also need a tracheostomy if you are in critical care and need to be on a breathing machine. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Tracheal Disease, also known as tracheal diseases, is related to tracheomalacia and tracheitis, and has symptoms including coughing and snoring. An important gene associated with Tracheal Disease is TEF (TEF, PAR BZIP Transcription Factor), and among its related pathways/superpathways is O-glycosylation of TSR domain-containing proteins. The drugs Lidocaine and Diazepam have been mentioned in the context of this disorder. Affiliated tissues include lung, trachea and heart, and related phenotype is mortality/aging.

Related Diseases for Tracheal Disease

Diseases related to Tracheal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 tracheomalacia 29.6 IYD SLC22A4 TBX4 TEF TUBB3
2 tracheitis 10.9
3 trachea leiomyoma 10.4 SLC22A4 TEF
4 olfactory groove meningioma 10.2 PGRMC1 RHNO1
5 esophageal atresia/tracheoesophageal fistula 10.2 TBX4 TEF
6 sphenoid sinusitis 10.1 PGRMC1 RHNO1
7 anterior cranial fossa meningioma 10.1 PGRMC1 RHNO1
8 weill-marchesani syndrome 10.0 ADAMTS10 ADAMTSL2
9 asthma 9.5
10 physical disorder 9.5 TGFB3 TUBB3
11 distal arthrogryposis 9.3 TGFB3 TUBB3
12 tracheal stenosis 6.3 ADAMTS10 ADAMTSL2 IYD PGRMC1 POC1A RHNO1

Graphical network of the top 20 diseases related to Tracheal Disease:

Diseases related to Tracheal Disease

Symptoms & Phenotypes for Tracheal Disease

UMLS symptoms related to Tracheal Disease:

coughing, snoring

MGI Mouse Phenotypes related to Tracheal Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.23 TEF TGFB3 TUBB3 ADAMTSL2 PGRMC1 POC1A

Drugs & Therapeutics for Tracheal Disease

Drugs for Tracheal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 237)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 137-58-6 3676
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
Atracurium Approved, Experimental, Investigational Phase 4,Not Applicable 64228-79-1 47319
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Atropine Approved, Vet_approved Phase 4,Not Applicable 5908-99-6, 51-55-8 174174
Rocuronium Approved Phase 4,Phase 3,Not Applicable 119302-91-9, 143558-00-3 441290
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 2078-54-8 4943
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
Methylene blue Approved, Investigational Phase 4,Not Applicable 61-73-4
Isoflurane Approved, Vet_approved Phase 4,Phase 1 26675-46-7 3763
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3 113775-47-6 68602 5311068
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
Neostigmine Approved, Vet_approved Phase 4,Not Applicable 59-99-4 4456
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
19 Poractant alfa Approved Phase 4,Phase 3,Phase 2,Not Applicable 129069-19-8
Etomidate Approved Phase 4 33125-97-2 36339 667484
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
Caffeine Approved, Nutraceutical Phase 4 58-08-2 2519
Imidazole Experimental, Investigational Phase 4 288-32-4 795
25 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
26 Respiratory System Agents Phase 4,Phase 3,Phase 2,Not Applicable
27 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Adjuvants, Anesthesia Phase 4,Not Applicable
29 Cholinergic Agents Phase 4,Phase 3,Not Applicable
30 GABA Agents Phase 4,Not Applicable
31 Muscarinic Antagonists Phase 4
32 Cholinergic Antagonists Phase 4,Phase 3
33 GABA Modulators Phase 4,Not Applicable
34 Mydriatics Phase 4
35 Narcotics Phase 4,Not Applicable
36 Sodium Channel Blockers Phase 4,Phase 2,Not Applicable
37 Neuromuscular Agents Phase 4,Phase 3,Not Applicable
38 Neuromuscular Blocking Agents Phase 4,Phase 3,Not Applicable
39 Neuromuscular Nondepolarizing Agents Phase 4,Phase 3,Not Applicable
40 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Analgesics, Opioid Phase 4,Not Applicable
42 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Anesthetics, Dissociative Phase 4
44 Anesthetics, General Phase 4,Phase 1,Not Applicable
45 Anesthetics, Intravenous Phase 4,Phase 1,Not Applicable
46 Anesthetics, Local Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Tranquilizing Agents Phase 4,Not Applicable
48 Diuretics, Potassium Sparing Phase 4,Phase 2,Not Applicable
49 Parasympatholytics Phase 4
50 Anti-Anxiety Agents Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 322)
# Name Status NCT ID Phase Drugs
1 The Comparison of Different Administration Routes of Pediatric Premedication Unknown status NCT02313337 Phase 4 Anesthesia induction(midazolam,fentanyl,propofol,atracurium);Anesthesia maintenance(midazolam,fentanyl,propofol,atracurium)
2 Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients Completed NCT02855502 Phase 4 Prednisolone;Placebo
3 Effectiveness and Safety of the Levitan Scope for Laryngoscopy and Tracheal Intubation With a Simulated Difficult Airway Completed NCT01491984 Phase 4
4 Early Versus Routine Caffeine Administration in Extremely Preterm Neonates Completed NCT01783561 Phase 4 Caffeine
5 Comparing Hemodynamic Changes for Intubation With Shikani Intubating Stylet and Macintosh Laryngoscope Completed NCT01271543 Phase 4
6 Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain Completed NCT03241602 Phase 4 Intraperitoneal lidocaine
7 Remifentanil Versus Sufentanil for Intubation Condition Without Myorelaxant Completed NCT01910285 Phase 4 Remifentanyl - sufentanil placebo;Sufentanil - remifentanyl placebo
8 Blind Intubation Through The Self-Pressurised Disposable Air-Q Laryngeal Intubation Mask: An International Multicentre Trial Completed NCT01906060 Phase 4
9 Sedation Effect of Dexmedetomidine Versus Remifentanil to Fibreoptic Intubation Completed NCT01474213 Phase 4 dexmedetomidine group;remifentanil group
10 Prospective, Randomized Clinical Trial Evaluating the ETView Double-Lumen Tube Completed NCT01807676 Phase 4
11 Checklists and Upright Positioning in Endotracheal Intubation of Critically Ill Patients (Check-UP) Trial Completed NCT02497729 Phase 4
12 Sugammadex vs. Placebo to Prevent Residual Neuromuscular Block in the Post--‐Anesthesia Care Unit Recruiting NCT02822001 Phase 4 Sugammadex;Placebo
13 Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use Recruiting NCT03491059 Phase 4 C-11 labeled nicotine
14 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
15 Comparison of Two Induction Regimens Using Topical Lidocaine or Muscle Relaxant on Sore Throat and Hemodynamics Recruiting NCT03031808 Phase 4 Lidocaine spray (2%);Muscle Relaxant (Rocuronium)
16 Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial Recruiting NCT02643381 Phase 4 Etomidate;Ketamine
17 Comparison of Double Lumen Tube Placement Techniques Recruiting NCT02495259 Phase 4
18 Comparison of Postoperative Delirium in Patients Anaesthetised With Isoflurane and Desflurane During Spinal Surgery Recruiting NCT02925611 Phase 4 Isoflurane;Desflurane
19 Exogenous Surfactant in Very Preterm Neonates in Prevention of Bronchopulmonary Dysplasia Active, not recruiting NCT01039285 Phase 4 Curosurf
20 Effects of Two Packing Type in Maxillofacial Surgery Active, not recruiting NCT03574246 Phase 4 chlorhexidine gluconate %0,12 benzydamine hydrochloride %0,15
21 Evaluation of Above the Cuff Suctioning During General Anesthesia Terminated NCT01386879 Phase 4 methylene blue
22 Role of a Silicone Prosthesis to Prevent Airway Obstruction Recurrence in Lung Cancers Terminated NCT01064050 Phase 4
23 Endoscopic Closure of Tracheoesophageal Fistulas With Occluder Device Terminated NCT01153061 Phase 4
24 Ambu Aura-i Laryngeal Mask Versus Air-Q Intubating Laryngeal Airway for Tracheal Intubation in Adults Unknown status NCT02226211 Phase 3
25 A Study to Determine the Dose Requirements of Rocuronium Bromide (Zemuron®) in Pediatric and Adolescent Subjects (21048)(COMPLETED)(P05797) Completed NCT00124735 Phase 3 Rocuronium bolus maintenance;rocuronium continuous infusion maintenance
26 A Study to Compare Different Intubating Doses of Zemuron in Pediatric and Adolescent Subjects Under General Anesthesia Completed NCT00124722 Phase 3 Rocuronium bromide (Zemuron);Rocuronium bromide (Zemuron);Rocuronium bromide (Zemuron)
27 Comparative Study of Rocuronium With Vecuronium (Study 71101)(COMPLETED) Completed NCT00970762 Phase 3 Rocuronium 0.6 mg/kg intubating dose;Rocuronium 0.9 mg/kg intubating dose;Rocuronium 0.1 mg/kg maintenance dose;Rocuronium 0.15 mg/kg maintenance dose;Rocuronium 0.2 mg/kg maintenance;Vecuronium 0.1 mg/kg intubating dose;Vecuronium 0.025 mg/kg maintenance dose
28 Effect Study of Modified Transoesophageal Echocardiography on Cerebral Embolization After Cardiothoracic Surgery Completed NCT01310608 Phase 3
29 Tolerance and Efficacy of Rituximab in Sjogren's Disease Completed NCT00740948 Phase 2, Phase 3 Rituximab (mabthera) Injection;Placebo: NaCl 0.9% or Glucose 5%
30 A Comparison of Bupivacaine and Ketorolac for Postoperative Analgesia After Iliac Crest Bone Harvesting Completed NCT00405262 Phase 3 Ketorolac;Bupivacaine;ketorolac + bupivacaine
31 PRINCE: Study of Atazanavir (ATV)/Ritonavir (RTV) Completed NCT01099579 Phase 3 Atazanavir powder;Ritonavir oral solution;Atazanavir capsules;Ritonavir capsules
32 Dexmedetomidine to Lessen Intensive Care Unit (ICU) Agitation Completed NCT01151865 Phase 2, Phase 3 Dexmedetomidine;Saline placebo
33 Curative Effect and Quality of Life Between Uniportal and Open Sleeve Lobectomy for Central Type Lung Cancer Recruiting NCT03523468 Phase 3
34 A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030) Recruiting NCT03449147 Phase 3 Gefapixant 45 mg BID;Gefapixant 15 mg BID;Placebo
35 Phase 3 Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-027) Recruiting NCT03449134 Phase 3 Gefapixant 45 mg BID;Gefapixant 15 mg BID;Placebo
36 A Study in Preterm Neonates With RDS to Compare CUROSURF® Administration Through LISA and Conventional Administration Not yet recruiting NCT02772081 Phase 3 Curosurf through conventional administration (endotracheal tube)
37 Efficacy and Safety of Goat Lung Surfactant for the Treatment of Respiratory Distress Syndrome in Preterm Neonates Not yet recruiting NCT02774044 Phase 2, Phase 3 Cadisurf;Survanta
38 The Gravity-VAP (Ventilator-Associated Pneumonia) Trial Terminated NCT01138540 Phase 3
39 Calfactant for Direct Acute Respiratory Distress Syndrome Terminated NCT00682500 Phase 3 Calfactant;Room Air (placebo)
40 Early FETO for Severe Congenital Diaphragmatic Hernia Unknown status NCT01731509 Phase 2
41 A Trail of a Novel Tracheal Radioactive Stent for the Malignant Airway Obstruction Unknown status NCT02565927 Phase 2 Iodine-125 seeds
42 Fetal Tracheal Occlusion in Severe Diaphragmatic Hernia: a Randomized Trial Unknown status NCT01302977 Phase 2
43 Coated Endotracheal Tube and Mucus Shaver to Prevent Hospital-Acquired Infections Completed NCT00341354 Phase 2
44 Comparison of the Macintosh, King Vision®, Glidescope® and AirTraq® Laryngoscopes in Routine Airway Management Completed NCT01914523 Phase 1, Phase 2
45 An Efficacy Study of GSK2269557 Added to Standard Care in Subjects With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease Completed NCT02294734 Phase 2 GSK2269557;Placebo
46 Study of Gefapixant (MK-7264) in Adult Japanese Participants With Unexplained or Refractory Chronic Cough (MK-7264-033) Completed NCT03482713 Phase 2 Gefapixant 45 mg;Placebo
47 Treatment of Acute Tracheitis and Laryngitis With Essential Oils of Aromatic Plants Completed NCT00611390 Phase 1, Phase 2
48 Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular Goiter Completed NCT00454220 Phase 2 MRrhTSH;MRrhTSH
49 Cytomegalovirus Control in Critical Care Completed NCT01503918 Phase 2 Valaciclovir/Aciclovir;Valganciclovir/Ganciclovir
50 Airway and/or Pulmonary Vessels Transplantation Recruiting NCT01331863 Phase 1, Phase 2

Search NIH Clinical Center for Tracheal Disease

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Tracheal Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Tracheal Disease:
InBreath System, a nanofiber scaffold seeded with mononuclear cells for tracheal injuries
Embryonic/Adult Cultured Cells Related to Tracheal Disease:
Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: tracheal diseases

Genetic Tests for Tracheal Disease

Anatomical Context for Tracheal Disease

MalaCards organs/tissues related to Tracheal Disease:

Lung, Trachea, Heart, Bone, Colon, Thyroid, Liver

Publications for Tracheal Disease

Articles related to Tracheal Disease:

# Title Authors Year
Two cases of tracheal disease misdiagnosed as difficult-to-treat asthma. ( 23431310 )
Preliminary study for a newly designed silicone stent and delivery system for canine obstructive tracheal disease. ( 22673748 )
Multidetector-row Computed Tomography of Diffuse Tracheal Disease: Pictorial Review. ( 23168465 )
Management of obstructive tracheal disease in children. ( 6481586 )
Structural considerations in tracheal disease. ( 517829 )

Variations for Tracheal Disease

Expression for Tracheal Disease

Search GEO for disease gene expression data for Tracheal Disease.

Pathways for Tracheal Disease

Pathways related to Tracheal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways

GO Terms for Tracheal Disease

Cellular components related to Tracheal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 8.8 PGRMC1 TGFB3 TUBB3

Biological processes related to Tracheal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 8.62 ADAMTSL2 TGFB3

Sources for Tracheal Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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