Tracheal Disease

Categories: Oral diseases, Respiratory diseases

Aliases & Classifications for Tracheal Disease

MalaCards integrated aliases for Tracheal Disease:

Name: Tracheal Disease 39 12 15
Tracheal Diseases 45 74
Tracheal Disorders 44


External Ids:

Disease Ontology 12 DOID:3225
MeSH 45 D014133
NCIt 51 C35079
SNOMED-CT 69 47125007
ICD10 34 S12.8
UMLS 74 C0040580

Summaries for Tracheal Disease

MedlinePlus : 44 Your trachea, or windpipe, is one part of your airway system. Airways are pipes that carry oxygen-rich air to your lungs. They also carry carbon dioxide, a waste gas, out of your lungs. When you inhale, air travels from your nose, through your larynx, and down your windpipe. The windpipe splits into two bronchi that enter your lungs. Problems with the trachea include narrowing, inflammation, and some inherited conditions. You may need a procedure called a tracheostomy to help you breathe if you have swallowing problems, or have conditions that affect coughing or block your airways. You might also need a tracheostomy if you are in critical care and need to be on a breathing machine. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Tracheal Disease, also known as tracheal diseases, is related to tracheomalacia and tracheitis, and has symptoms including snoring and coughing. An important gene associated with Tracheal Disease is TEF (TEF Transcription Factor, PAR BZIP Family Member), and among its related pathways/superpathways is O-glycosylation of TSR domain-containing proteins. The drugs Atracurium and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include lung, trachea and colon.

Wikipedia : 77 The trachea, colloquially called the windpipe, is a cartilaginous tube that connects the pharynx and... more...

Related Diseases for Tracheal Disease

Graphical network of the top 20 diseases related to Tracheal Disease:

Diseases related to Tracheal Disease

Symptoms & Phenotypes for Tracheal Disease

UMLS symptoms related to Tracheal Disease:

snoring, coughing

Drugs & Therapeutics for Tracheal Disease

Drugs for Tracheal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 250)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Atracurium Approved, Experimental, Investigational Phase 4,Not Applicable 64228-79-1 47319
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 2078-54-8 4943
Atropine Approved, Vet_approved Phase 4,Not Applicable 5908-99-6, 51-55-8 174174
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Isoflurane Approved, Vet_approved Phase 4,Phase 1 26675-46-7 3763
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
Rocuronium Approved Phase 4,Phase 3,Not Applicable 119302-91-9, 143558-00-3 441290
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 137-58-6 3676
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Chlorhexidine Approved, Vet_approved Phase 4,Not Applicable 55-56-1 2713 9552079
Benzydamine Approved Phase 4 642-72-8, 100-46-9 7504
Sodium Citrate Approved, Investigational Phase 4 68-04-2
Caffeine Approved Phase 4 58-08-2 2519
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2 113775-47-6 5311068 68602
Neostigmine Approved, Vet_approved Phase 4,Not Applicable 59-99-4 4456
24 Poractant alfa Approved Phase 4,Phase 3,Phase 2,Not Applicable 129069-19-8
Methylene blue Approved, Investigational Phase 4,Not Applicable 61-73-4
Nicotine Approved Phase 4,Not Applicable 54-11-5 89594 942
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
Etomidate Approved Phase 4 33125-97-2 667484 36339
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
Imidazole Experimental, Investigational Phase 4 288-32-4 795
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
33 Mydriatics Phase 4
34 Parasympatholytics Phase 4
35 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Analgesics, Opioid Phase 4,Not Applicable
38 Excitatory Amino Acid Antagonists Phase 4
39 Neuromuscular Agents Phase 4,Phase 3,Not Applicable
40 Anti-Arrhythmia Agents Phase 4,Phase 2,Not Applicable
41 Cholinergic Agents Phase 4,Phase 3,Not Applicable
42 Cholinergic Antagonists Phase 4,Phase 3,Not Applicable
43 Anti-Asthmatic Agents Phase 4
44 Autonomic Agents Phase 4,Not Applicable
45 Psychotropic Drugs Phase 4,Not Applicable
46 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Anesthetics, Dissociative Phase 4
49 Anesthetics, Intravenous Phase 4,Phase 1,Not Applicable
50 Narcotics Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 376)
# Name Status NCT ID Phase Drugs
1 The Comparison of Different Administration Routes of Pediatric Premedication Unknown status NCT02313337 Phase 4 Anesthesia induction(midazolam,fentanyl,propofol,atracurium);Anesthesia maintenance(midazolam,fentanyl,propofol,atracurium)
2 Comparison of Postoperative Delirium in Patients Anaesthetised With Isoflurane and Desflurane During Spinal Surgery Unknown status NCT02925611 Phase 4 Isoflurane;Desflurane
3 Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients Completed NCT02855502 Phase 4 Prednisolone;Placebo
4 Effects of Two Packing Type in Maxillofacial Surgery Completed NCT03574246 Phase 4 chlorhexidine gluconate %0,12 benzydamine hydrochloride %0,15
5 Effectiveness and Safety of the Levitan Scope for Laryngoscopy and Tracheal Intubation With a Simulated Difficult Airway Completed NCT01491984 Phase 4
6 Early Versus Routine Caffeine Administration in Extremely Preterm Neonates Completed NCT01783561 Phase 4 Caffeine
7 Comparing Hemodynamic Changes for Intubation With Shikani Intubating Stylet and Macintosh Laryngoscope Completed NCT01271543 Phase 4
8 Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain Completed NCT03241602 Phase 4 Intraperitoneal lidocaine
9 Remifentanil Versus Sufentanil for Intubation Condition Without Myorelaxant Completed NCT01910285 Phase 4 Remifentanyl - sufentanil placebo;Sufentanil - remifentanyl placebo
10 Blind Intubation Through The Self-Pressurised Disposable Air-Q Laryngeal Intubation Mask: An International Multicentre Trial Completed NCT01906060 Phase 4
11 Sedation Effect of Dexmedetomidine Versus Remifentanil to Fibreoptic Intubation Completed NCT01474213 Phase 4 dexmedetomidine group;remifentanil group
12 Prospective, Randomized Clinical Trial Evaluating the ETView Double-Lumen Tube Completed NCT01807676 Phase 4
13 Checklists and Upright Positioning in Endotracheal Intubation of Critically Ill Patients (Check-UP) Trial Completed NCT02497729 Phase 4
14 Sugammadex vs. Placebo to Prevent Residual Neuromuscular Block in the Post--‐Anesthesia Care Unit Recruiting NCT02822001 Phase 4 Sugammadex;Placebo
15 Lidocaine to Prevent Cough and Hemodynamic Changes in Tracheal Extubation Recruiting NCT03731429 Phase 4 Lidocaine;Saline Solution
16 Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use Recruiting NCT03491059 Phase 4 C-11 labeled nicotine
17 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
18 Comparison of Two Induction Regimens Using Topical Lidocaine or Muscle Relaxant on Sore Throat and Hemodynamics Recruiting NCT03031808 Phase 4 Lidocaine spray (2%);Muscle Relaxant (Rocuronium)
19 Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial Recruiting NCT02643381 Phase 4 Etomidate;Ketamine
20 Transanastomotic Tube for Proximal Esophageal Atresia With Distal Tracheoesophageal Fistula Repair Recruiting NCT03730454 Phase 4
21 Exogenous Surfactant in Very Preterm Neonates in Prevention of Bronchopulmonary Dysplasia Active, not recruiting NCT01039285 Phase 4 Curosurf
22 Does Depth of Neuromuscular Blockade (NMB) Affect Surgical Conditions in Obese Patients Undergoing Robotic Surgery Not yet recruiting NCT03591289 Phase 4 NMB with rocuronium bromide
23 Avoiding Neuromuscular Blockers to Reduce Complications Not yet recruiting NCT03962725 Phase 4 Neuromuscular Blocking Agents;Anesthetic Adjuncts
24 Premedication for Less Invasive Surfactant Administration Not yet recruiting NCT03735563 Phase 4 Ketamine;Fentanyl
25 Remifentanil Plus Ketamine for Dynamic Flexible Bronchoscopy Not yet recruiting NCT03613792 Phase 4 Remifentanil;Fentanyl;Midazolam;Ketamine
26 Evaluation of Above the Cuff Suctioning During General Anesthesia Terminated NCT01386879 Phase 4 methylene blue
27 Role of a Silicone Prosthesis to Prevent Airway Obstruction Recurrence in Lung Cancers Terminated NCT01064050 Phase 4
28 Endoscopic Closure of Tracheoesophageal Fistulas With Occluder Device Terminated NCT01153061 Phase 4
29 Ambu Aura-i Laryngeal Mask Versus Air-Q Intubating Laryngeal Airway for Tracheal Intubation in Adults Unknown status NCT02226211 Phase 3
30 Efficacy and Safety of Goat Lung Surfactant for the Treatment of Respiratory Distress Syndrome in Preterm Neonates Unknown status NCT02774044 Phase 2, Phase 3 Cadisurf;Survanta
31 A Study to Determine the Dose Requirements of Rocuronium Bromide (Zemuron®) in Pediatric and Adolescent Subjects (21048)(COMPLETED)(P05797) Completed NCT00124735 Phase 3 Rocuronium bolus maintenance;rocuronium continuous infusion maintenance
32 A Study to Compare Different Intubating Doses of Zemuron in Pediatric and Adolescent Subjects Under General Anesthesia Completed NCT00124722 Phase 3 Rocuronium bromide (Zemuron);Rocuronium bromide (Zemuron);Rocuronium bromide (Zemuron)
33 Comparative Study of Rocuronium With Vecuronium (Study 71101)(COMPLETED) Completed NCT00970762 Phase 3 Rocuronium 0.6 mg/kg intubating dose;Rocuronium 0.9 mg/kg intubating dose;Rocuronium 0.1 mg/kg maintenance dose;Rocuronium 0.15 mg/kg maintenance dose;Rocuronium 0.2 mg/kg maintenance;Vecuronium 0.1 mg/kg intubating dose;Vecuronium 0.025 mg/kg maintenance dose
34 Effect Study of Modified Transoesophageal Echocardiography on Cerebral Embolization After Cardiothoracic Surgery Completed NCT01310608 Phase 3
35 Tolerance and Efficacy of Rituximab in Sjogren's Disease Completed NCT00740948 Phase 2, Phase 3 Rituximab (mabthera) Injection;Placebo: NaCl 0.9% or Glucose 5%
36 Study of DA-9501 In Pediatric Subjects In The Intensive Care Unit Completed NCT02757625 Phase 3 Dexmedetomidine hydrochloride
37 A Comparison of Bupivacaine and Ketorolac for Postoperative Analgesia After Iliac Crest Bone Harvesting Completed NCT00405262 Phase 3 Ketorolac;Bupivacaine;ketorolac + bupivacaine
38 PRINCE: Study of Atazanavir (ATV)/Ritonavir (RTV) Completed NCT01099579 Phase 3 Atazanavir powder;Ritonavir oral solution;Atazanavir capsules;Ritonavir capsules
39 Surfactant Positive Airway Pressure and Pulse Oximetry Trial Completed NCT00233324 Phase 3 Surfactant;Supplemental oxygen with target saturation of 85 to 89%;Supplemental oxygen with target saturation of 91 to 95%
40 Dexmedetomidine to Lessen Intensive Care Unit (ICU) Agitation Completed NCT01151865 Phase 2, Phase 3 Dexmedetomidine;Saline placebo
41 Curative Effect and Quality of Life Between Uniportal and Open Sleeve Lobectomy for Central Type Lung Cancer Recruiting NCT03523468 Phase 3
42 A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030) Recruiting NCT03449147 Phase 3 Gefapixant 45 mg BID;Gefapixant 15 mg BID;Placebo
43 Phase 3 Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-027) Recruiting NCT03449134 Phase 3 Gefapixant 45 mg BID;Gefapixant 15 mg BID;Placebo
44 A Study in Preterm Neonates With RDS to Compare CUROSURF® Administration Through LISA and Conventional Administration Suspended NCT02772081 Phase 3 Curosurf through conventional administration (endotracheal tube)
45 The Gravity-VAP (Ventilator-Associated Pneumonia) Trial Terminated NCT01138540 Phase 3
46 Calfactant for Direct Acute Respiratory Distress Syndrome Terminated NCT00682500 Phase 3 Calfactant;Room Air (placebo)
47 Early FETO for Severe Congenital Diaphragmatic Hernia Unknown status NCT01731509 Phase 2
48 A Trail of a Novel Tracheal Radioactive Stent for the Malignant Airway Obstruction Unknown status NCT02565927 Phase 2 Iodine-125 seeds
49 Fetal Tracheal Occlusion in Severe Diaphragmatic Hernia: a Randomized Trial Unknown status NCT01302977 Phase 2
50 Coated Endotracheal Tube and Mucus Shaver to Prevent Hospital-Acquired Infections Completed NCT00341354 Phase 2

Search NIH Clinical Center for Tracheal Disease

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Tracheal Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Tracheal Disease:
InBreath System, a nanofiber scaffold seeded with mononuclear cells for tracheal injuries
Embryonic/Adult Cultured Cells Related to Tracheal Disease:
Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: tracheal diseases

Genetic Tests for Tracheal Disease

Anatomical Context for Tracheal Disease

MalaCards organs/tissues related to Tracheal Disease:

Lung, Trachea, Colon, Thyroid, Lymph Node, Skin, Testes

Publications for Tracheal Disease

Articles related to Tracheal Disease:

# Title Authors Year
Two cases of tracheal disease misdiagnosed as difficult-to-treat asthma. ( 23431310 )
Preliminary study for a newly designed silicone stent and delivery system for canine obstructive tracheal disease. ( 22673748 )
CT of diffuse tracheal diseases. ( 21343471 )
Multidetector-row Computed Tomography of Diffuse Tracheal Disease: Pictorial Review. ( 23168465 )
Development of tracheal surgery: a historical review. Part 2: Treatment of tracheal diseases. ( 12645751 )
Surgical treatment for tracheal diseases. A report of 72 cases. ( 2997344 )
Management of obstructive tracheal disease in children. ( 6481586 )
Structural considerations in tracheal disease. ( 517829 )

Variations for Tracheal Disease

Expression for Tracheal Disease

Search GEO for disease gene expression data for Tracheal Disease.

Pathways for Tracheal Disease

Pathways related to Tracheal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways

GO Terms for Tracheal Disease

Biological processes related to Tracheal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 8.62 ADAMTSL2 TGFB3

Sources for Tracheal Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
33 HPO
34 ICD10
35 ICD10 via Orphanet
39 LifeMap
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
56 Novoseek
59 OMIM via Orphanet
63 PubMed
71 SNOMED-CT via Orphanet
73 Tocris
75 UMLS via Orphanet
Loading form....