Tracheal Disease

Categories: Oral diseases, Respiratory diseases

Aliases & Classifications for Tracheal Disease

MalaCards integrated aliases for Tracheal Disease:

Name: Tracheal Disease 38 12 15
Tracheal Diseases 44 73
Tracheal Disorders 43


External Ids:

Disease Ontology 12 DOID:3225
ICD10 33 S12.8
MeSH 44 D014133
NCIt 50 C35079
SNOMED-CT 68 47125007
UMLS 73 C0040580

Summaries for Tracheal Disease

MedlinePlus : 43 Your trachea, or windpipe, is one part of your airway system. Airways are pipes that carry oxygen-rich air to your lungs. They also carry carbon dioxide, a waste gas, out of your lungs. When you inhale, air travels from your nose, through your larynx, and down your windpipe. The windpipe splits into two bronchi that enter your lungs. Problems with the trachea include narrowing, inflammation, and some inherited conditions. You may need a procedure called a tracheostomy to help you breathe if you have swallowing problems, or have conditions that affect coughing or block your airways. You might also need a tracheostomy if you are in critical care and need to be on a breathing machine. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Tracheal Disease, also known as tracheal diseases, is related to tracheomalacia and tracheitis, and has symptoms including snoring and coughing. An important gene associated with Tracheal Disease is TEF (TEF, PAR BZIP Transcription Factor), and among its related pathways/superpathways is O-glycosylation of TSR domain-containing proteins. The drugs Atracurium and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include lung, trachea and heart, and related phenotype is mortality/aging.

Wikipedia : 76 The trachea, colloquially called the windpipe, is a cartilaginous tube that connects the pharynx and... more...

Related Diseases for Tracheal Disease

Graphical network of the top 20 diseases related to Tracheal Disease:

Diseases related to Tracheal Disease

Symptoms & Phenotypes for Tracheal Disease

UMLS symptoms related to Tracheal Disease:

snoring, coughing

MGI Mouse Phenotypes related to Tracheal Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.23 ADAMTSL2 PGRMC1 POC1A SLC22A4 TBX4 TEF

Drugs & Therapeutics for Tracheal Disease

Drugs for Tracheal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 249)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Atracurium Approved, Experimental, Investigational Phase 4,Not Applicable 64228-79-1 47319
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 2078-54-8 4943
Atropine Approved, Vet_approved Phase 4,Not Applicable 51-55-8, 5908-99-6 174174
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Isoflurane Approved, Vet_approved Phase 4,Phase 1 26675-46-7 3763
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
Rocuronium Approved Phase 4,Phase 3,Not Applicable 119302-91-9, 143558-00-3 441290
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 137-58-6 3676
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Caffeine Approved Phase 4 58-08-2 2519
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2 113775-47-6 68602 5311068
Neostigmine Approved, Vet_approved Phase 4,Not Applicable 59-99-4 4456
21 Poractant alfa Approved Phase 4,Phase 3,Phase 2,Not Applicable 129069-19-8
Chlorhexidine Approved, Vet_approved Phase 4,Not Applicable 55-56-1 2713 9552079
Methylene blue Approved, Investigational Phase 4,Not Applicable 61-73-4
Nicotine Approved Phase 4,Not Applicable 54-11-5 942 89594
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
Etomidate Approved Phase 4 33125-97-2 667484 36339
Benzydamine Approved Phase 4 100-46-9, 642-72-8 7504
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
Imidazole Experimental, Investigational Phase 4 288-32-4 795
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
31 Mydriatics Phase 4
32 Parasympatholytics Phase 4
33 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Analgesics, Opioid Phase 4,Not Applicable
36 Excitatory Amino Acid Antagonists Phase 4
37 Neuromuscular Agents Phase 4,Phase 3,Not Applicable
38 Anti-Arrhythmia Agents Phase 4,Phase 2,Not Applicable
39 Cholinergic Agents Phase 4,Phase 3,Not Applicable
40 Cholinergic Antagonists Phase 4,Phase 3
41 Anti-Asthmatic Agents Phase 4
42 Autonomic Agents Phase 4,Not Applicable
43 Psychotropic Drugs Phase 4,Not Applicable
44 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Anesthetics, Dissociative Phase 4
47 Anesthetics, Intravenous Phase 4,Phase 1,Not Applicable
48 Narcotics Phase 4,Not Applicable
49 Anti-Anxiety Agents Phase 4,Not Applicable
50 Neuromuscular Blocking Agents Phase 4,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 346)
# Name Status NCT ID Phase Drugs
1 The Comparison of Different Administration Routes of Pediatric Premedication Unknown status NCT02313337 Phase 4 Anesthesia induction(midazolam,fentanyl,propofol,atracurium);Anesthesia maintenance(midazolam,fentanyl,propofol,atracurium)
2 Comparison of Postoperative Delirium in Patients Anaesthetised With Isoflurane and Desflurane During Spinal Surgery Unknown status NCT02925611 Phase 4 Isoflurane;Desflurane
3 Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients Completed NCT02855502 Phase 4 Prednisolone;Placebo
4 Effectiveness and Safety of the Levitan Scope for Laryngoscopy and Tracheal Intubation With a Simulated Difficult Airway Completed NCT01491984 Phase 4
5 Early Versus Routine Caffeine Administration in Extremely Preterm Neonates Completed NCT01783561 Phase 4 Caffeine
6 Comparing Hemodynamic Changes for Intubation With Shikani Intubating Stylet and Macintosh Laryngoscope Completed NCT01271543 Phase 4
7 Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain Completed NCT03241602 Phase 4 Intraperitoneal lidocaine
8 Remifentanil Versus Sufentanil for Intubation Condition Without Myorelaxant Completed NCT01910285 Phase 4 Remifentanyl - sufentanil placebo;Sufentanil - remifentanyl placebo
9 Blind Intubation Through The Self-Pressurised Disposable Air-Q Laryngeal Intubation Mask: An International Multicentre Trial Completed NCT01906060 Phase 4
10 Sedation Effect of Dexmedetomidine Versus Remifentanil to Fibreoptic Intubation Completed NCT01474213 Phase 4 dexmedetomidine group;remifentanil group
11 Prospective, Randomized Clinical Trial Evaluating the ETView Double-Lumen Tube Completed NCT01807676 Phase 4
12 Checklists and Upright Positioning in Endotracheal Intubation of Critically Ill Patients (Check-UP) Trial Completed NCT02497729 Phase 4
13 Sugammadex vs. Placebo to Prevent Residual Neuromuscular Block in the Post--‐Anesthesia Care Unit Recruiting NCT02822001 Phase 4 Sugammadex;Placebo
14 Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use Recruiting NCT03491059 Phase 4 C-11 labeled nicotine
15 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
16 Comparison of Two Induction Regimens Using Topical Lidocaine or Muscle Relaxant on Sore Throat and Hemodynamics Recruiting NCT03031808 Phase 4 Lidocaine spray (2%);Muscle Relaxant (Rocuronium)
17 Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial Recruiting NCT02643381 Phase 4 Etomidate;Ketamine
18 Transanastomotic Tube for Proximal Esophageal Atresia With Distal Tracheoesophageal Fistula Repair Recruiting NCT03730454 Phase 4
19 Exogenous Surfactant in Very Preterm Neonates in Prevention of Bronchopulmonary Dysplasia Active, not recruiting NCT01039285 Phase 4 Curosurf
20 Effects of Two Packing Type in Maxillofacial Surgery Active, not recruiting NCT03574246 Phase 4 chlorhexidine gluconate %0,12 benzydamine hydrochloride %0,15
21 Lidocaine to Prevent Cough and Hemodynamic Changes in Tracheal Extubation Not yet recruiting NCT03731429 Phase 4 Lidocaine;Saline Solution
22 Does Depth of Neuromuscular Blockade (NMB) Affect Surgical Conditions in Obese Patients Undergoing Robotic Surgery Not yet recruiting NCT03591289 Phase 4 NMB with rocuronium bromide
23 Premedication for Less Invasive Surfactant Administration Not yet recruiting NCT03735563 Phase 4 Ketamine;Fentanyl
24 Remifentanil Plus Ketamine for Dynamic Flexible Bronchoscopy Not yet recruiting NCT03613792 Phase 4 Remifentanil;Fentanyl;Midazolam;Ketamine
25 Evaluation of Above the Cuff Suctioning During General Anesthesia Terminated NCT01386879 Phase 4 methylene blue
26 Role of a Silicone Prosthesis to Prevent Airway Obstruction Recurrence in Lung Cancers Terminated NCT01064050 Phase 4
27 Endoscopic Closure of Tracheoesophageal Fistulas With Occluder Device Terminated NCT01153061 Phase 4
28 Ambu Aura-i Laryngeal Mask Versus Air-Q Intubating Laryngeal Airway for Tracheal Intubation in Adults Unknown status NCT02226211 Phase 3
29 A Study to Determine the Dose Requirements of Rocuronium Bromide (Zemuron®) in Pediatric and Adolescent Subjects (21048)(COMPLETED)(P05797) Completed NCT00124735 Phase 3 Rocuronium bolus maintenance;rocuronium continuous infusion maintenance
30 A Study to Compare Different Intubating Doses of Zemuron in Pediatric and Adolescent Subjects Under General Anesthesia Completed NCT00124722 Phase 3 Rocuronium bromide (Zemuron);Rocuronium bromide (Zemuron);Rocuronium bromide (Zemuron)
31 Comparative Study of Rocuronium With Vecuronium (Study 71101)(COMPLETED) Completed NCT00970762 Phase 3 Rocuronium 0.6 mg/kg intubating dose;Rocuronium 0.9 mg/kg intubating dose;Rocuronium 0.1 mg/kg maintenance dose;Rocuronium 0.15 mg/kg maintenance dose;Rocuronium 0.2 mg/kg maintenance;Vecuronium 0.1 mg/kg intubating dose;Vecuronium 0.025 mg/kg maintenance dose
32 Effect Study of Modified Transoesophageal Echocardiography on Cerebral Embolization After Cardiothoracic Surgery Completed NCT01310608 Phase 3
33 Tolerance and Efficacy of Rituximab in Sjogren's Disease Completed NCT00740948 Phase 2, Phase 3 Rituximab (mabthera) Injection;Placebo: NaCl 0.9% or Glucose 5%
34 Study of DA-9501 In Pediatric Subjects In The Intensive Care Unit Completed NCT02757625 Phase 3 Dexmedetomidine hydrochloride
35 A Comparison of Bupivacaine and Ketorolac for Postoperative Analgesia After Iliac Crest Bone Harvesting Completed NCT00405262 Phase 3 Ketorolac;Bupivacaine;ketorolac + bupivacaine
36 PRINCE: Study of Atazanavir (ATV)/Ritonavir (RTV) Completed NCT01099579 Phase 3 Atazanavir powder;Ritonavir oral solution;Atazanavir capsules;Ritonavir capsules
37 Dexmedetomidine to Lessen Intensive Care Unit (ICU) Agitation Completed NCT01151865 Phase 2, Phase 3 Dexmedetomidine;Saline placebo
38 Curative Effect and Quality of Life Between Uniportal and Open Sleeve Lobectomy for Central Type Lung Cancer Recruiting NCT03523468 Phase 3
39 A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030) Recruiting NCT03449147 Phase 3 Gefapixant 45 mg BID;Gefapixant 15 mg BID;Placebo
40 Phase 3 Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-027) Recruiting NCT03449134 Phase 3 Gefapixant 45 mg BID;Gefapixant 15 mg BID;Placebo
41 A Study in Preterm Neonates With RDS to Compare CUROSURF® Administration Through LISA and Conventional Administration Not yet recruiting NCT02772081 Phase 3 Curosurf through conventional administration (endotracheal tube)
42 Efficacy and Safety of Goat Lung Surfactant for the Treatment of Respiratory Distress Syndrome in Preterm Neonates Not yet recruiting NCT02774044 Phase 2, Phase 3 Cadisurf;Survanta
43 The Gravity-VAP (Ventilator-Associated Pneumonia) Trial Terminated NCT01138540 Phase 3
44 Calfactant for Direct Acute Respiratory Distress Syndrome Terminated NCT00682500 Phase 3 Calfactant;Room Air (placebo)
45 Percutaneous Endoscopic Tracheal Plug/Unplug for CDH Unknown status NCT00768703 Phase 1, Phase 2
46 Early FETO for Severe Congenital Diaphragmatic Hernia Unknown status NCT01731509 Phase 2
47 A Trail of a Novel Tracheal Radioactive Stent for the Malignant Airway Obstruction Unknown status NCT02565927 Phase 2 Iodine-125 seeds
48 Fetal Tracheal Occlusion in Severe Diaphragmatic Hernia: a Randomized Trial Unknown status NCT01302977 Phase 2
49 Coated Endotracheal Tube and Mucus Shaver to Prevent Hospital-Acquired Infections Completed NCT00341354 Phase 2
50 Comparison of the Macintosh, King Vision®, Glidescope® and AirTraq® Laryngoscopes in Routine Airway Management Completed NCT01914523 Phase 1, Phase 2

Search NIH Clinical Center for Tracheal Disease

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Tracheal Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Tracheal Disease:
InBreath System, a nanofiber scaffold seeded with mononuclear cells for tracheal injuries
Embryonic/Adult Cultured Cells Related to Tracheal Disease:
Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: tracheal diseases

Genetic Tests for Tracheal Disease

Anatomical Context for Tracheal Disease

MalaCards organs/tissues related to Tracheal Disease:

Lung, Trachea, Heart, Bone

Publications for Tracheal Disease

Articles related to Tracheal Disease:

# Title Authors Year
Two cases of tracheal disease misdiagnosed as difficult-to-treat asthma. ( 23431310 )
Preliminary study for a newly designed silicone stent and delivery system for canine obstructive tracheal disease. ( 22673748 )
CT of diffuse tracheal diseases. ( 21343471 )
Multidetector-row Computed Tomography of Diffuse Tracheal Disease: Pictorial Review. ( 23168465 )
Development of tracheal surgery: a historical review. Part 2: Treatment of tracheal diseases. ( 12645751 )
Surgical treatment for tracheal diseases. A report of 72 cases. ( 2997344 )
Management of obstructive tracheal disease in children. ( 6481586 )
Structural considerations in tracheal disease. ( 517829 )

Variations for Tracheal Disease

Expression for Tracheal Disease

Search GEO for disease gene expression data for Tracheal Disease.

Pathways for Tracheal Disease

Pathways related to Tracheal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways

GO Terms for Tracheal Disease

Biological processes related to Tracheal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 8.62 ADAMTSL2 TGFB3

Sources for Tracheal Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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