MCID: TRC026
MIFTS: 38

Tracheal Disease

Categories: Fetal diseases, Oral diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Tracheal Disease

MalaCards integrated aliases for Tracheal Disease:

Name: Tracheal Disease 12 15 37
Tracheal Diseases 43 71
Tracheal Disorders 42
Tracheal Anomaly 58

Classifications:

Orphanet: 58  
Developmental anomalies during embryogenesis


External Ids:

Disease Ontology 12 DOID:3225
MeSH 43 D014133
NCIt 49 C35079
SNOMED-CT 67 47125007
ICD10 32 S12.8
Orphanet 58 ORPHA156252
UMLS 71 C0040580

Summaries for Tracheal Disease

MedlinePlus : 42 Your trachea, or windpipe, is one part of your airway system. Airways are pipes that carry oxygen-rich air to your lungs. They also carry carbon dioxide, a waste gas, out of your lungs. When you inhale, air travels from your nose, through your larynx, and down your windpipe. The windpipe splits into two bronchi that enter your lungs. Problems with the trachea include narrowing, inflammation, and some inherited conditions. You may need a procedure called a tracheostomy to help you breathe if you have swallowing problems, or have conditions that affect coughing or block your airways. You might also need a tracheostomy if you are in critical care and need to be on a breathing machine. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Tracheal Disease, also known as tracheal diseases, is related to tracheitis and tracheomalacia, and has symptoms including snoring and coughing. An important gene associated with Tracheal Disease is TEF (TEF Transcription Factor, PAR BZIP Family Member). The drugs Ketorolac and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include lung, trachea and heart, and related phenotype is homeostasis/metabolism.

Wikipedia : 74 The trachea, colloquially called the windpipe, is a cartilaginous tube that connects the larynx to the... more...

Related Diseases for Tracheal Disease

Diseases related to Tracheal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)
# Related Disease Score Top Affiliating Genes
1 tracheitis 31.6 SLC22A4 POLI CRP BACE1
2 tracheomalacia 30.1 ZBED1 TEF TBX4 SLC22A4 RHNO1 LRRC1
3 exophthalmos 29.9 RHNO1 PRTN3 CRP
4 tracheal stenosis 28.6 TEF TBRG1 SLC22A4 RHNO1 PRTN3 LRRC1
5 genetic tracheal anomaly 12.3
6 cardiac-urogenital syndrome 11.4
7 vacterl association 11.3
8 sclerosing keratitis 10.5 TEF PRTN3
9 pectus carinatum 10.5 FBN1 COL2A1
10 deep keratitis 10.5 TEF PRTN3
11 geleophysic dysplasia 3 10.5 TBRG1 ADAMTSL2
12 ectopia lentis 1, isolated, autosomal dominant 10.5 FBN1 ADAMTS10
13 retinal lattice degeneration 10.4 FBN1 COL2A1
14 ectopia lentis 2, isolated, autosomal recessive 10.4 FBN1 ADAMTS10
15 acute maxillary sinusitis 10.4 RHNO1 CRP
16 vagus nerve disease 10.4 ATP4A ATP12A
17 hemangioma of intra-abdominal structure 10.4 ATP4A ATP12A
18 acquired gastric outlet stenosis 10.4 ATP4A ATP12A
19 displacement of cardia through esophageal hiatus 10.4 ATP4A ATP12A
20 angiodysplasia of intestine 10.4 ATP4A ATP12A
21 benzylpenicillin allergy 10.4 ATP4A ATP12A
22 granulomatous gastritis 10.4 ATP4A ATP12A
23 cavernous sinus thrombosis 10.4 RHNO1 CRP
24 bacterial esophagitis 10.4 ATP4A ATP12A
25 cascade stomach 10.4 ATP4A ATP12A
26 gastrojejunal ulcer 10.4 ATP4A ATP12A
27 laryngeal tuberculosis 10.4 ATP4A ATP12A
28 fungal esophagitis 10.4 ATP4A ATP12A
29 dieulafoy lesion 10.4 ATP4A ATP12A
30 esophagus melanoma 10.4 ATP4A ATP12A
31 cervix erosion 10.4 ATP4A ATP12A
32 gastric gastrinoma 10.4 ATP4A ATP12A
33 subdural empyema 10.4 RHNO1 CRP
34 chronic laryngitis 10.4 ATP4A ATP12A
35 cefuroxime allergy 10.4 ATP4A ATP12A
36 polyposis, skin pigmentation, alopecia, and fingernail changes 10.4 ATP4A ATP12A
37 chronic intestinal vascular insufficiency 10.4 ATP4A ATP12A
38 intracranial sinus thrombosis 10.4 RHNO1 CRP
39 rumination disorder 10.4 ATP4A ATP12A
40 blind loop syndrome 10.4 ATP4A ATP12A
41 larsen syndrome 10.4 TBX4 GALNS COL2A1
42 acute laryngitis 10.4 ATP4A ATP12A
43 gastroduodenitis 10.4 ATP4A ATP12A
44 duodenal gastrinoma 10.4 ATP4A ATP12A
45 orbital cellulitis 10.4 RHNO1 CRP
46 geleophysic dysplasia 1 10.4 TBRG1 FBN1 ADAMTSL2
47 acute orbital inflammation 10.4 RHNO1 CRP
48 geleophysic dysplasia 2 10.4 TBRG1 FBN1 ADAMTSL2
49 internal hemorrhoid 10.4 ATP4A ATP12A
50 pancreatic gastrinoma 10.4 ATP4A ATP12A

Graphical network of the top 20 diseases related to Tracheal Disease:



Diseases related to Tracheal Disease

Symptoms & Phenotypes for Tracheal Disease

UMLS symptoms related to Tracheal Disease:


snoring, coughing

MGI Mouse Phenotypes related to Tracheal Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.44 ADAMTSL2 ANO1 ATP12A ATP4A BACE1 COL2A1

Drugs & Therapeutics for Tracheal Disease

Drugs for Tracheal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketorolac Approved 66635-83-4, 74103-06-3 3826
2
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
3
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
4 Mitogens
5 Anesthetics
6 Gastrointestinal Agents
7 Hormones
8 Antineoplastic Agents, Hormonal
9 Analgesics, Non-Narcotic
10 Antiemetics
11 Hormone Antagonists
12 Analgesics
13 Cyclooxygenase Inhibitors
14 glucocorticoids
15 BB 1101
16 Antirheumatic Agents
17 Anti-Inflammatory Agents
18 Anti-Inflammatory Agents, Non-Steroidal

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Replacement of the Airways and/or the Pulmonary Vessels Using a Cryopreserved Arterial Allograft Unknown status NCT01331863 Phase 1, Phase 2
2 Clinical Trial Evaluation of Stem-cell Based Bioartificial Airway Transplantation for Patients With Benign and Malignant Laryngo-tracheal Diseases Unknown status NCT01997437
3 Factors to Obstructive Granulation Tissue Formation After Ultraflex Stenting in Benign Tracheal Narrowing Completed NCT01006200
4 Simplification and Implementation of Awake Fibreoptic Orotracheal Intubation Completed NCT03343496
5 Study of Bacterial Colonization of the Respiratory Tract in Long-term Tracheostomized Patients With Neurological or Neuromuscular Disease Completed NCT02400086
6 The Effect of Prophylactic Ketorolac on Sore Throat After Thyroid Surgery Completed NCT02039427 Ketorolac;Placebo
7 Tracheobronchial Bioengineering Using Aortic Matrices Recruiting NCT04263129
8 Force of Endotracheal Tube Extubation; Esophagus vs. Trachea; an Exploratory Crossover Clinical Trial Terminated NCT03480425
9 Outcomes of Using LNMES on Tracheostomized Children Withdrawn NCT03227627

Search NIH Clinical Center for Tracheal Disease

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Tracheal Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Tracheal Disease:
InBreath System, a nanofiber scaffold seeded with mononuclear cells for tracheal injuries
Embryonic/Adult Cultured Cells Related to Tracheal Disease:
Bone marrow-derived mononuclear cells (family)

Cochrane evidence based reviews: tracheal diseases

Genetic Tests for Tracheal Disease

Anatomical Context for Tracheal Disease

MalaCards organs/tissues related to Tracheal Disease:

40
Lung, Trachea, Heart, Bone, Colon, Thyroid, Uterus

Publications for Tracheal Disease

Articles related to Tracheal Disease:

(show top 50) (show all 88)
# Title Authors PMID Year
1
Successful rescue using tracheal intubation cannula for severe central airway stenosis after tracheotomy: A CARE compliant case report. 42
32481279 2020
2
Tracheoesophageal fistula associated with bevacizumab after thoracic radiotherapy in non-small cell lung cancer: A case report. 42
32332657 2020
3
Necrotizing tracheobronchitis causing airway obstruction complicated by pandemic 2009 H1N1 influenza: A case report. 42
31895828 2020
4
[Prognostic Risk Factors for Patients Receiving Airway Stent Placement]. 61
32517450 2020
5
Radiographic tracheal lumen to vertebral ratios in the normal American Miniature Horse. 61
31596505 2020
6
Reactivity Study of a Biodegradable Polydioxanone Tracheal Stent in a Rabbit Model. 61
32229053 2020
7
Correction to: Development of an efficient perfusion-based protocol for whole-organ decellularization of the ovine uterus as a human-sized model and in vivo application of the bioscaffolds. 61
31522369 2019
8
Low recurrence of lung adenoid cystic carcinoma with radiotherapy and resection. 61
31067606 2019
9
Idiopathic Subglottic Tracheal Stenosis in Identical Twin Sisters. 61
31384592 2019
10
Tracheobronchopathia osteochondroplastica: a rare tracheal lesion in a free-ranging grizzly bear. 61
31006353 2019
11
Correction to: Development of an efficient perfusion-based protocol for whole-organ decellularization of the ovine uterus as a human-sized model and in vivo application of the bioscaffolds. 61
31165388 2019
12
Neonatal Tracheal and Intracardiac Repair in a High-Risk Premature Infant Requiring Preoperative ECMO Transport. 61
28825386 2019
13
Polydimethylsiloxane/nano calcium phosphate composite tracheal stents: Mechanical and physiological properties. 61
29732669 2019
14
A 3-dimensional bioprinted tracheal segment implant pilot study: Rabbit tracheal resection with graft implantation. 61
30579077 2019
15
The use of extracorporeal membrane oxygenation in the anticipated difficult airway: a case report and systematic review. 61
29497994 2018
16
Distal Tracheal Resection and Reconstruction: State of the Art and Lessons Learned. 61
29627054 2018
17
Complex Tracheocarinal Reconstructions Using Extrathoracic Muscle Flaps as Airway Substitutes. 61
29427616 2018
18
Tracheal surgery in children: outcome of a 12-year survey. 61
29244167 2018
19
Imaging of the trachea. 61
29707497 2018
20
Recurrent respiratory papillomatosis with lung involvement. 61
30406011 2018
21
Tracheobroncopathia osteochondroplastica: Three case reports with literature review. 61
28406134 2017
22
Thoracoscopic tracheal resection and reconstruction using two ports approach. 61
29078582 2017
23
Biomechanical and biochemical characterization of porcine tracheal cartilage. 61
26825682 2016
24
Effect of cell seeding on neotissue formation in a tissue engineered trachea. 61
26552897 2016
25
Surgical treatment of air way disease. 61
26904257 2016
26
Laryngeal preservation in managing advanced tracheal adenoid cystic carcinoma. 61
25878915 2015
27
Tracheal bioengineering: the next steps. Proceeds of an International Society of Cell Therapy Pulmonary Cellular Therapy Signature Series Workshop, Paris, France, April 22, 2014. 61
25457172 2014
28
Online learning in thoracic surgical training: promising results of multi-institutional pilot study. 61
25085560 2014
29
Pediatric cardiothoracic surgery in patients with unilateral pulmonary agenesis or aplasia. 61
24507772 2014
30
Indications and interventional options for non-resectable tracheal stenosis. 61
24624290 2014
31
Tissue engineering in the trachea. 61
24293389 2014
32
Adenoid cystic carcinoma in the bronchus behaves more aggressively than its tracheal counterpart. 61
24094522 2013
33
Two cases of tracheal disease misdiagnosed as difficult-to-treat asthma. 61
23431310 2013
34
Preliminary study for a newly designed silicone stent and delivery system for canine obstructive tracheal disease. 61
22673748 2012
35
[Tracheal diseases]. 61
21809234 2011
36
FSI analysis of a human trachea before and after prosthesis implantation. 61
21823742 2011
37
CT of diffuse tracheal diseases. 61
21343471 2011
38
Tracheal torsion assessed by a computer-generated 3-dimensional image analysis predicts tracheal self-expandable metallic stent fracture. 61
20579664 2010
39
A tissue-engineered trachea derived from a framed collagen scaffold, gingival fibroblasts and adipose-derived stem cells. 61
20347137 2010
40
Factors leading to obstructive granulation tissue formation after ultraflex stenting in benign tracheal narrowing. 61
20333573 2010
41
Upper airway. 4: Sarcoidosis of the upper respiratory tract (SURT). 61
20147594 2010
42
[Antimicrobial and antimycotic therapy in the surgery of iatrogenic esophageal and tracheal diseases]. 61
20336037 2010
43
Tracheal amyloidosis-an unusual cause of stridor. 61
19444779 2009
44
[Summary of 2008 national conference on laryngological and tracheal diseases]. 61
19558878 2009
45
Multidetector-row Computed Tomography of Diffuse Tracheal Disease: Pictorial Review. 61
23168465 2009
46
Tracheobronchopathia osteochondroplastica: presentation of ten cases and review of the literature. 61
18463923 2008
47
Self-expanding nitinol stents for the treatment of tracheal collapse in dogs: 12 cases (2001-2004). 61
18275390 2008
48
Tracheocele; a case of rare clinical entity. 61
18932034 2008
49
Wegener's granulomatosis: current trends in diagnosis and management. 61
17483685 2007
50
Clinical trial of photodynamic therapy with meso-tetra (hydroxyphenyl) chlorin for respiratory papillomatosis. 61
15723939 2005

Variations for Tracheal Disease

Expression for Tracheal Disease

Search GEO for disease gene expression data for Tracheal Disease.

Pathways for Tracheal Disease

GO Terms for Tracheal Disease

Cellular components related to Tracheal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.26 FBN1 COL2A1 ADAMTSL2 ADAMTS10
2 microfibril GO:0001527 8.62 FBN1 ADAMTS10

Biological processes related to Tracheal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular sodium ion homeostasis GO:0006883 9.32 ATP4A ATP12A
2 sodium ion export across plasma membrane GO:0036376 9.26 ATP4A ATP12A
3 cellular potassium ion homeostasis GO:0030007 9.16 ATP4A ATP12A
4 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.96 ATP4A ATP12A
5 extracellular matrix organization GO:0030198 8.92 FBN1 COL2A1 ADAMTSL2 ADAMTS10

Molecular functions related to Tracheal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Tracheal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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