MCID: TRC018
MIFTS: 26

Tracheal Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Respiratory diseases

Aliases & Classifications for Tracheal Lymphoma

MalaCards integrated aliases for Tracheal Lymphoma:

Name: Tracheal Lymphoma 12 15 71
Lymphoma of the Trachea 12
Lymphoma of Trachea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12001
NCIt 49 C6248
UMLS 71 C1336773

Summaries for Tracheal Lymphoma

MalaCards based summary : Tracheal Lymphoma, also known as lymphoma of the trachea, is related to lymphosarcoma and nodal marginal zone lymphoma. An important gene associated with Tracheal Lymphoma is ACP2 (Acid Phosphatase 2, Lysosomal), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and B Cell Development Pathways. Affiliated tissues include trachea, b cells and t cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Tracheal Lymphoma

Diseases related to Tracheal Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 lymphosarcoma 29.7 TNFRSF8 BCL6
2 nodal marginal zone lymphoma 29.4 SPN MME IGHV4-38-2 CD5 BCL6
3 lymphoma, hodgkin, classic 29.3 TNFRSF8 PAX5 BCL6
4 lymphoma 28.6 TNFRSF8 PAX5 MME CXCL13 CD5 CCND2
5 mantle cell lymphoma 28.2 SPN SOX11 PAX5 MME CD5 CCND2
6 marginal zone b-cell lymphoma 28.1 TNFRSF8 SPN PAX5 MME IGHV4-38-2 CD5
7 b-cell lymphoma 28.0 TNFRSF8 PAX5 MME CXCL13 CD5 CCND2
8 lymphoma, mucosa-associated lymphoid type 27.2 TNFRSF8 SPN SDC1 PAX5 MME IGHV4-38-2
9 lymphoma, non-hodgkin, familial 26.5 TNFRSF8 SPN SDC1 PAX5 MME IGHV4-38-2
10 thyrotoxic exophthalmos 10.4 MME CD5
11 submandibular adenitis 10.3 TNFRSF8 PAX5
12 endocrine exophthalmos 10.3 MME CD5
13 malignant leydig cell tumor 10.3 SPN PAX5
14 sclerosing hepatic carcinoma 10.3 MME CD5
15 parapsoriasis 10.3 TNFRSF8 CD5
16 breast lipoma 10.3 TNFRSF8 PAX5
17 mediastinal malignant lymphoma 10.3 TNFRSF8 PAX5
18 mediastinal gray zone lymphoma 10.3 TNFRSF8 PAX5
19 lymphoepithelioma-like thymic carcinoma 10.2 TNFRSF8 CD5
20 lethal midline granuloma 10.2 TNFRSF8 SPN
21 mediastinal cancer 10.2 TNFRSF8 PAX5 CD5
22 central epithelioid sarcoma 10.1 TNFRSF8 MME
23 vulvar proximal-type epithelioid sarcoma 10.1 TNFRSF8 MME
24 alpha chain disease 10.1 SPN CD5
25 ureteral lymphoma 10.1 MME BCL6
26 nasal cavity lymphoma 10.1 IGHV4-38-2 CD5
27 heart lymphoma 10.1 MME BCL6
28 hodgkin's lymphoma, mixed cellularity 10.1 TNFRSF8 SPN PAX5
29 ovarian lymphoma 10.1 MME BCL6
30 leukemia, acute lymphoblastic 3 10.1 PAX5 MME CXCL13
31 retina lymphoma 10.1 IGHV4-38-2 CXCL13
32 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.0 TNFRSF8 BCL6
33 primary cutaneous b-cell lymphoma 10.0 PAX5 BCL6
34 plasmacytoma 10.0
35 mental retardation, autosomal dominant 33 10.0 PAX5 MME IGHV4-38-2
36 prostate lymphoma 10.0 MME CD5 BCL6
37 epiglottis neoplasm 10.0 MME CD5 BCL6
38 liver lymphoma 10.0 MME CD5 BCL6
39 colon lymphoma 10.0 MME CD5 BCL6
40 t-cell adult acute lymphocytic leukemia 10.0 TNFRSF8 CD5
41 intravascular large b-cell lymphoma 10.0 MME CD5 BCL6
42 hodgkin's lymphoma, lymphocytic depletion 10.0 TNFRSF8 PAX5 IGHV4-38-2
43 monoclonal paraproteinemia 10.0 SDC1 PAX5
44 richter's syndrome 10.0 SPN IGHV4-38-2 CD5
45 respiratory failure 9.9
46 nodular lymphocyte predominant hodgkin lymphoma 9.9 TNFRSF8 PAX5 BCL6
47 chromosome 13q14 deletion syndrome 9.9 IGHV4-38-2 CD5
48 autoimmune lymphoproliferative syndrome, type v 9.9 TNFRSF8 CD5 BCL6
49 paranasal sinus lymphoma 9.9 TNFRSF8 PAX5 BCL6
50 t-cell/histiocyte rich large b cell lymphoma 9.9 TNFRSF8 MME BCL6

Graphical network of the top 20 diseases related to Tracheal Lymphoma:



Diseases related to Tracheal Lymphoma

Symptoms & Phenotypes for Tracheal Lymphoma

MGI Mouse Phenotypes related to Tracheal Lymphoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 ACP2 BCL6 CCND2 CD5 CXCL13 MCOLN1
2 immune system MP:0005387 9.77 ACP2 BCL6 CCND2 CD5 CXCL13 GFER
3 integument MP:0010771 9.17 ACP2 BCL6 CD5 MCOLN1 MME SDC1

Drugs & Therapeutics for Tracheal Lymphoma

Search Clinical Trials , NIH Clinical Center for Tracheal Lymphoma

Genetic Tests for Tracheal Lymphoma

Anatomical Context for Tracheal Lymphoma

MalaCards organs/tissues related to Tracheal Lymphoma:

40
Trachea, B Cells, T Cells, Breast, Eye, Bone, Retina

Publications for Tracheal Lymphoma

Articles related to Tracheal Lymphoma:

(show all 12)
# Title Authors PMID Year
1
Successful treatment of tracheal lymphoma in a Siamese cat. 61
29204289 2017
2
Primary tracheal malignant lymphoma detected during a regular checkup in an asbestos dust-exposed smoker. 61
24942797 2014
3
Primary anaplastic large cell lymphoma of trachea with subcutaneous emphysema and progressive dyspnea. 61
22198193 2011
4
What is your diagnosis? Tracheal lymphoma. 61
20433391 2010
5
Primary tracheal lymphoma causing respiratory failure. 61
18670314 2008
6
Primary tracheal lymphoma: case report and literature review. 61
16298827 2005
7
Laser therapy for an obstructing primary tracheal lymphoma in a patient with AIDS. 61
15785798 2005
8
Primary high-grade non-Hodgkin lymphoma of the trachea in an adolescent. 61
12775538 2003
9
Primary lymphoplasmacytoid lymphoma of the trachea with immunoglobulin G paraprotein. 61
10632932 1999
10
Malignant lymphoma presenting as tracheal tumor: a case report. 61
8935233 1996
11
Sjögren's syndrome: severe upper airways obstruction due to primary malignant tracheal lymphoma developing during successful treatment of lymphocytic interstitial pneumonitis. 61
3625640 1987
12
[Tracheal lymphoma]. 61
5660616 1968

Variations for Tracheal Lymphoma

Expression for Tracheal Lymphoma

Search GEO for disease gene expression data for Tracheal Lymphoma.

Pathways for Tracheal Lymphoma

Pathways related to Tracheal Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.32 SPN SDC1 MME CD5
2 10.89 TNFRSF8 SPN SDC1 PAX5 MME CD5

GO Terms for Tracheal Lymphoma

Biological processes related to Tracheal Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 8.96 TNFRSF8 SPN
2 germinal center formation GO:0002467 8.62 CXCL13 BCL6

Molecular functions related to Tracheal Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 8.8 TNFRSF8 SPN CD5

Sources for Tracheal Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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