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MCID: TRC005
MIFTS: 39

Tracheal Stenosis

Categories: Respiratory diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Tracheal Stenosis

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MalaCards integrated aliases for Tracheal Stenosis:

Name: Tracheal Stenosis 12 29 44 15 73
Stenosis of Trachea 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3227
MeSH 44 D014135
NCIt 50 C78646
SNOMED-CT 68 11296007
UMLS 73 C0040583
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Summaries for Tracheal Stenosis

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MalaCards based summary : Tracheal Stenosis, also known as stenosis of trachea, is related to tracheomalacia and congenital tracheal stenosis. An important gene associated with Tracheal Stenosis is ADAMTSL2 (ADAMTS Like 2), and among its related pathways/superpathways are O-glycosylation of TSR domain-containing proteins and Elastic fibre formation. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include trachea, heart and lung.

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Related Diseases for Tracheal Stenosis

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Diseases in the Tracheal Stenosis family:

Congenital Tracheal Stenosis

Diseases related to Tracheal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 tracheomalacia 29.8 IYD SLC22A4 TEF
2 congenital tracheal stenosis 12.2
3 idiopathic subglottic tracheal stenosis 12.2
4 anterior chamber cleavage disorder, cerebellar hypoplasia, hypothyroidism, and tracheal stenosis 12.0
5 tracheobronchial stenosis, congenital 11.5
6 geleophysic dysplasia 1 11.2
7 geleophysic dysplasia 2 11.1
8 geleophysic dysplasia 3 11.1
9 geleophysic dwarfism 11.1
10 jung wolff back stahl syndrome 11.1
11 geleophysic dysplasia 10.3 ADAMTSL2 FBN1
12 laryngitis 10.3
13 trachea leiomyoma 10.3 SLC22A4 TEF
14 esophagitis 10.2
15 diaphragmatic eventration 10.1 FBN1 TEF
16 heart disease 10.1
17 asthma 10.1
18 cervicitis 10.1
19 tracheoesophageal fistula 10.1
20 mediastinitis 10.1
21 olfactory groove meningioma 10.0 PGRMC1 RHNO1
22 lung agenesis 10.0
23 aneurysm 10.0
24 weill-marchesani syndrome 10.0 ADAMTS10 ADAMTSL2 FBN1
25 esophageal cancer 10.0
26 burns 10.0
27 thyroiditis 10.0
28 sphenoid sinusitis 10.0 PGRMC1 RHNO1
29 tetralogy of fallot 9.9
30 tracheoesophageal fistula with or without esophageal atresia 9.9
31 tracheopathia osteoplastica 9.9
32 down syndrome 9.9
33 lung cancer 9.9
34 mucopolysaccharidosis, type ii 9.9
35 esophageal atresia 9.9
36 respiratory failure 9.9
37 goiter 9.9
38 relapsing polychondritis 9.9
39 anterior cranial fossa meningioma 9.9 PGRMC1 RHNO1
40 wegener granulomatosis 9.8
41 laryngotracheitis 9.8
42 lymphoma 9.8
43 thyroid cancer 9.8
44 fibrosing mediastinitis 9.8
45 igg4-related disease 9.8
46 pfeiffer syndrome 9.7
47 systemic lupus erythematosus 9.7
48 pectus excavatum 9.7
49 rheumatoid arthritis 9.7
50 small cell cancer of the lung 9.7

Graphical network of the top 20 diseases related to Tracheal Stenosis:



Diseases related to Tracheal Stenosis
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Symptoms & Phenotypes for Tracheal Stenosis

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Drugs & Therapeutics for Tracheal Stenosis

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Drugs for Tracheal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3 Antiemetics Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Antineoplastic Agents, Hormonal Phase 4
6 Autonomic Agents Phase 4
7 Gastrointestinal Agents Phase 4
8 glucocorticoids Phase 4
9 Hormone Antagonists Phase 4
10 Hormones Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
12 Methylprednisolone acetate Phase 4
13 Methylprednisolone Hemisuccinate Phase 4
14 Neuroprotective Agents Phase 4
15 Peripheral Nervous System Agents Phase 4,Not Applicable
16 Prednisolone acetate Phase 4
17 Prednisolone hemisuccinate Phase 4
18 Prednisolone phosphate Phase 4
19 Protective Agents Phase 4
20
Glucosamine Approved, Investigational, Nutraceutical Phase 1, Phase 2 3416-24-8 439213
21 Anticoagulants Phase 1, Phase 2
22 Antimetabolites Phase 1, Phase 2
23 Fibrinolytic Agents Phase 1, Phase 2
24 Glucuronyl glucosamine glycan sulfate Phase 1, Phase 2
25 Hypoglycemic Agents Phase 1, Phase 2
26 Hypolipidemic Agents Phase 1, Phase 2
27 Lipid Regulating Agents Phase 1, Phase 2
28
Menthol Approved Not Applicable 2216-51-5 16666
29
Temazepam Approved, Investigational Not Applicable 846-50-4 5391
30
Levobupivacaine Approved, Investigational Not Applicable 27262-47-1 92253
31
Atracurium Approved, Experimental, Investigational Not Applicable 64228-79-1 47319
32
Bupivacaine Approved, Investigational Not Applicable 2180-92-9, 38396-39-3 2474
33
Dexmedetomidine Approved, Vet_approved Not Applicable 113775-47-6 68602 5311068
34
Fentanyl Approved, Illicit, Investigational, Vet_approved Not Applicable 437-38-7 3345
35
Propofol Approved, Investigational, Vet_approved Not Applicable 2078-54-8 4943
36 Anesthetics Not Applicable
37 Alkylating Agents Not Applicable
38 Anti-Bacterial Agents Not Applicable
39 Antibiotics, Antitubercular Not Applicable
40 Mitomycins Not Applicable
41 Nucleic Acid Synthesis Inhibitors Not Applicable
42 Anesthetics, Local Not Applicable
43 Antipruritics Not Applicable
44 Dermatologic Agents Not Applicable
45 Central Nervous System Depressants Not Applicable
46 Adrenergic Agents Not Applicable
47 Adrenergic Agonists Not Applicable
48 Adrenergic alpha-2 Receptor Agonists Not Applicable
49 Adrenergic alpha-Agonists Not Applicable
50 Analgesics Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients Completed NCT02855502 Phase 4 Prednisolone;Placebo
2 Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells Recruiting NCT03130374 Phase 1, Phase 2
3 Airway and/or Pulmonary Vessels Transplantation Recruiting NCT01331863 Phase 1, Phase 2
4 Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants Withdrawn NCT01977911 Phase 1, Phase 2
5 A Study to Assess the Safety, Tolerability and Potential Efficacy of a Tracheal Replacement Consisting of a Tissue-engineered Tracheal Scaffold With Seeded Mesenchymal Cells Suspended NCT02949414 Phase 1
6 Biodegradable Stents in the Management of Stenoses of the Large Airways Unknown status NCT02620319 Not Applicable
7 Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis Completed NCT00705848
8 Modified Endotracheal Balloon Dilator to Improve Patient Oxygenation and Allow Ventilation During Airway Procedures Completed NCT02796326 Not Applicable
9 Estimation of Intrinsic Positive End-Expiratory Pressure (PEEP) in Acute Respiratory Distress Syndrome (ARDS) Completed NCT00446706
10 Factors to Obstructive Granulation Tissue Formation After Ultraflex Stenting in Benign Tracheal Narrowing Completed NCT01006200
11 A Clinical Trial on Effectiveness and Safety of Hydrogen Generator to Treat Dyspnea for the Patients With Tracheal Stenosis: A Randomized, Double-blind and Single-center Clinical Study Recruiting NCT02961387 Not Applicable
12 Study of Mitomycin-C Application in Laryngotracheal Stenosis Recruiting NCT01523275 Not Applicable Mitomycin -C
13 Gold Laser Vs. Micro-Debriders for Functional Endoscopic Sinus Surgery Recruiting NCT02900794 Not Applicable
14 Brainstem Dysfunction Involvement in the Pathogenesis of Pierre Robin Sequence Recruiting NCT03423017 Not Applicable
15 Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients Recruiting NCT03455881
16 trūFreeze® Spray Cryotherapy Patient Registry Active, not recruiting NCT01802203
17 Local Wound Infiltration for Tracheal Reconstruction Enrolling by invitation NCT02949661 Not Applicable
18 Endotracheal Dilator to Improve Oxygenation Not yet recruiting NCT03411928 Not Applicable
19 Dexmedetomidine for Bilateral Superficial Cervical Plexus Block for Reconstructive Tracheal Surgery Not yet recruiting NCT03426527 Not Applicable Levobupivacaine;Levobupivacaine-Dexmedetomidine
20 MRI Review of Tracheal Dimensions Terminated NCT00277953
21 Ventilator Associated Pneumonia and Late Complications of Percutaneous Tracheostomy Terminated NCT00184925 Not Applicable
22 Office-based Radial Expansion Balloon Dilation of the Esophagus and Trachea Withdrawn NCT00583960

Search NIH Clinical Center for Tracheal Stenosis

Cochrane evidence based reviews: tracheal stenosis

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Genetic Tests for Tracheal Stenosis

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Genetic tests related to Tracheal Stenosis:

# Genetic test Affiliating Genes
1 Tracheal Stenosis 29
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Anatomical Context for Tracheal Stenosis

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MalaCards organs/tissues related to Tracheal Stenosis:

41
Trachea, Heart, Lung, Thyroid, B Cells, Cortex, T Cells
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Publications for Tracheal Stenosis

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Articles related to Tracheal Stenosis:

(show top 50) (show all 661)
# Title Authors Year
1
Difficulty in tracheal extubation followed by tracheal collapse after balloon dilatation for tracheal stenosis therapy: A case report. ( 29851818 )
2018
2
Tracheal stenosis-resection and reconstruction. ( 29707510 )
2018
3
Cervical Tracheal Resection and Anastomosis for Postintubation Tracheal Stenosis. ( 29742573 )
2018
4
Endoscopic and Surgical Treatment of Benign Tracheal Stenosis: A Multidisciplinary Team Approach. ( 29877219 )
2018
5
Anesthetic Management for Concomitant Correction of Congenital Cardiac Defects and Long "O" Ring Tracheal Stenosis: A Role for Heliox?: Report of 2 Cases. ( 29611831 )
2018
6
Successful Use of Aortic Homograft for Residual Tracheal Stenosis Following Slide Tracheoplasty. ( 29518535 )
2018
7
Intubation in two patients with difficult airway management and tracheal stenosis after tracheostomy in thoracic surgery. ( 29429553 )
2018
8
Impact of 3D printing on the surgical management of tracheal stenosis associated to pulmonary sling: a case report. ( 29607202 )
2018
9
Ventilation strategy and anesthesia management in patients with severe tracheal stenosis undergoing urgent tracheal stenting. ( 29315465 )
2018
10
Erythromycin combined with corticosteroid reduced inflammation and modified trauma-induced tracheal stenosis in a rabbit model. ( 29781361 )
2018
11
Unexpected Exacerbation of Tracheal Stenosis in a Patient with Hunter Syndrome Undergoing Cardiac Surgery. ( 29862088 )
2018
12
High-flow nasal cannula oxygenation during interventional bronchoscopy in a patient with severe tracheal stenosis. ( 29428824 )
2018
13
Two Bronchogenic Cysts Causing Tracheal Stenosis in an Infant. ( 29099998 )
2018
14
Incidental Diagnosis of Congenital Tracheal Stenosis in Children With Congenital Heart Disease Presenting for Cardiac Surgery. ( 29753667 )
2018
15
A novel simple external fixation for securing silicone stent in patients with upper tracheal stenosis. ( 29707372 )
2018
16
Functional outcome after (laryngo)tracheal resection and reconstruction for acquired benign (laryngo)tracheal stenosis. ( 29707500 )
2018
17
Successful Treatment of Life-threatening Tracheal Stenosis Caused by Malignancy with a Self-expanding Hybrid Stent. ( 29093400 )
2018
18
Difficult intubation due to unknown congenital tracheal stenosis in the adult: a case report and literature review. ( 29607194 )
2018
19
Role of the impulse oscillometry in the evaluation of tracheal stenosis. ( 29627402 )
2018
20
Bronchial Mismatch as a Predictor of Respiratory Failure After Congenital Tracheal Stenosis Repair. ( 29397926 )
2018
21
Surgical management of children presenting with surgical-needed tracheal stenosis. ( 29605358 )
2018
22
Profilactic role of simvastatin and mitomycin C in tracheal stenosis after tracheal damage: Study in rats. ( 29447825 )
2018
23
Anesthetic Management in Tracheal Dilatation for Severe Tracheal Stenosis. ( 29961932 )
2018
24
Tracheal A-frame Deformity: A Challenging Variant of Tracheal Stenosis. ( 29394162 )
2018
25
Jet ventilation in obese patients undergoing airway surgery for subglottic and tracheal stenosis. ( 29288493 )
2017
26
Membranous tracheal stenosis in a patient with anorexia nervosa and self-induced vomiting- challenges in securing the airway. ( 28377879 )
2017
27
Left pulmonary artery sling and congenital tracheal stenosis: to slide or not to slide? ( 29312682 )
2017
28
Partial cricotracheal resection for severe upper tracheal stenosis: Potential impacts on the outcome. ( 28363712 )
2017
29
Maintenance of balance between airway pressure and intracranial pressure in a patient with tracheal stenosis undergoing craniotomy: a case report. ( 28017177 )
2017
30
The Relationship between Body Mass, Tracheal Diameter, Endotracheal Tube Size, and Tracheal Stenosis. ( 27930416 )
2017
31
A canine model of tracheal stenosis induced by cuffed endotracheal intubation. ( 28349955 )
2017
32
Resection and anastomosis for benign tracheal stenosis: Single institution experience of 18 cases. ( 28869225 )
2017
33
An Adolescent with Dyspnea and Cough. A Case of Congenital Tracheal Stenosis. ( 28683205 )
2017
34
Item Selection and Content Validity of the Risk Factors of Post-Intubation Tracheal Stenosis Observation Questionnaire for ICU-Admitted Patients. ( 28638421 )
2017
35
Concentric photothermal coagulation with basket-integrated optical device for treatment of tracheal stenosis. ( 28731623 )
2017
36
Clinical implications of differentiating between types of post-tracheostomy tracheal stenosis. ( 29268510 )
2017
37
The role of adjunctive procedures in reducing postoperative tracheobronchial obstruction in single lung patients with congenital tracheal stenosis undergoing slide tracheoplasty. ( 28185629 )
2017
38
Bedside ultrasonography to guide intubation for a patient with an unexpected cervical tracheal stenosis: a case report. ( 28220484 )
2017
39
The "Hitch Stitch": An Effective Method of Preventing Migration in High Tracheal Stenosis. ( 27988514 )
2017
40
Significant Amelioration of Tracheal Stenosis following Lenvatinib in a Patient Who Has Anaplastic Thyroid Carcinoma with Bronchomediastinal Infiltration: A Case Report. ( 28413394 )
2017
41
Surgical treatment of postintubation tracheal stenosis: A retrospective 22-patient series from a single center. ( 28412038 )
2017
42
A rare cause of noninvasive ventilation failure: tracheal stenosis. ( 29631533 )
2017
43
Changes in Tracheostomy- and Intubation-Related Tracheal Stenosis: Implications for Surgery. ( 28619544 )
2017
44
Topical mitomycin C application for the control of recurrent tracheal stenosis even after tracheal surgery. ( 29297460 )
2017
45
To do or not to do? The management dilemma of congenital tracheal stenosis in the setting of the ring-sling complex. ( 29312686 )
2017
46
Management of congenital tracheal stenosis in the neonatal period. ( 28801794 )
2017
47
Operative or non-operative treatment of congenital tracheal stenosis: is there something new? ( 29312681 )
2017
48
Comparison between traditional and small-diameter tube-assisted bronchoscopic balloon dilatation in the treatment of benign tracheal stenosis. ( 28296266 )
2017
49
An Overview of Tracheal Stenosis Research Trends and Hot Topics. ( 29048922 )
2017
50
A new technique for treatment of tracheal stenosis. ( 28374983 )
2017
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Variations for Tracheal Stenosis

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Expression for Tracheal Stenosis

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Search GEO for disease gene expression data for Tracheal Stenosis.
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Pathways for Tracheal Stenosis

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Pathways related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
O-glycosylation of TSR domain-containing proteins 66
Show member pathways
 10.84 ADAMTS10 ADAMTSL2
2
Elastic fibre formation 66
Show member pathways
 10.49 FBN1 TGFB3
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GO Terms for Tracheal Stenosis

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Cellular components related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.13 ADAMTS10 FBN1 TGFB3
2 microfibril GO:0001527 8.62 ADAMTS10 FBN1

Biological processes related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 8.62 ADAMTSL2 TGFB3

Molecular functions related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.32 ADAMTS10 ADAMTSL2 FBN1 IYD PGRMC1 POC1A
Sources

Sources for Tracheal Stenosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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