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MCID: TRC005
MIFTS: 40

Tracheal Stenosis

Categories: Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Tracheal Stenosis

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MalaCards integrated aliases for Tracheal Stenosis:

Name: Tracheal Stenosis 12 29 44 15 73
Stenosis of Trachea 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3227
MeSH 44 D014135
NCIt 50 C78646
SNOMED-CT 68 11296007
UMLS 73 C0040583
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Summaries for Tracheal Stenosis

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MalaCards based summary : Tracheal Stenosis, also known as stenosis of trachea, is related to tracheomalacia and pneumothorax. An important gene associated with Tracheal Stenosis is ADAMTSL2 (ADAMTS Like 2), and among its related pathways/superpathways are O-glycosylation of TSR domain-containing proteins and Elastic fibre formation. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include trachea, lung and heart, and related phenotype is mortality/aging.

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Related Diseases for Tracheal Stenosis

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Diseases in the Tracheal Stenosis family:

Congenital Tracheal Stenosis

Diseases related to Tracheal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 tracheomalacia 30.5 SLC22A4 TEF
2 pneumothorax 29.6 FBN1 SLC22A4
3 congenital tracheal stenosis 12.4
4 idiopathic subglottic tracheal stenosis 12.4
5 anterior chamber cleavage disorder, cerebellar hypoplasia, hypothyroidism, and tracheal stenosis 12.2
6 tracheobronchial stenosis, congenital 11.7
7 geleophysic dysplasia 1 11.4
8 geleophysic dysplasia 2 11.2
9 geleophysic dysplasia 3 11.2
10 geleophysic dwarfism 11.2
11 jung wolff back stahl syndrome 11.2
12 heart disease 10.3
13 asthma 10.2
14 tracheoesophageal fistula 10.2
15 lung agenesis 10.1
16 acromicric dysplasia 10.1 FBN1 LTBP3
17 esophageal cancer 10.1
18 tracheoesophageal fistula with or without esophageal atresia 10.1
19 esophageal atresia 10.1
20 goiter 10.1
21 trachea leiomyoma 10.1 SLC22A4 TEF
22 diaphragmatic eventration 10.0 FBN1 TEF
23 geleophysic dysplasia 10.0 ADAMTSL2 FBN1 LTBP3
24 tetralogy of fallot 10.0
25 tracheopathia osteoplastica 10.0
26 down syndrome 10.0
27 lung cancer 10.0
28 mucopolysaccharidosis, type ii 10.0
29 respiratory failure 10.0
30 relapsing polychondritis 10.0
31 isolated ectopia lentis 10.0 ADAMTS10 ADAMTSL2 FBN1
32 weill-marchesani syndrome 10.0 ADAMTS10 ADAMTSL2 FBN1
33 olfactory groove meningioma 9.9 PGRMC1 RHNO1
34 burns 9.9
35 lymphoma 9.9
36 thyroid cancer 9.9
37 mediastinitis 9.9
38 fibrosing mediastinitis 9.9
39 igg4-related disease 9.9
40 sphenoid sinusitis 9.9 PGRMC1 RHNO1
41 peters-plus syndrome 9.9 ADAMTS10 ADAMTSL2
42 anterior cranial fossa meningioma 9.9 PGRMC1 RHNO1
43 pfeiffer syndrome 9.8
44 systemic lupus erythematosus 9.8
45 pectus excavatum 9.8
46 rheumatoid arthritis 9.8
47 small cell cancer of the lung 9.8
48 autism 9.8
49 chondrodysplasia punctata syndrome 9.8
50 corpus callosum, agenesis of, with facial anomalies and robin sequence 9.8

Graphical network of the top 20 diseases related to Tracheal Stenosis:



Diseases related to Tracheal Stenosis
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Symptoms & Phenotypes for Tracheal Stenosis

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MGI Mouse Phenotypes related to Tracheal Stenosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.17 ADAMTSL2 FBN1 LTBP3 PGRMC1 POC1A SLC22A4
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Drugs & Therapeutics for Tracheal Stenosis

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Drugs for Tracheal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
6 Peripheral Nervous System Agents Phase 4,Not Applicable
7 Antineoplastic Agents, Hormonal Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9 Hormone Antagonists Phase 4
10 Hormones Phase 4
11 glucocorticoids Phase 4
12 Antiemetics Phase 4
13 Gastrointestinal Agents Phase 4
14 Prednisolone acetate Phase 4
15 Neuroprotective Agents Phase 4
16 Anti-Inflammatory Agents Phase 4
17 Autonomic Agents Phase 4
18 Protective Agents Phase 4
19 Methylprednisolone acetate Phase 4
20
Glucosamine Approved, Investigational Phase 1, Phase 2 3416-24-8 439213
21 Glucuronyl glucosamine glycan sulfate Phase 1, Phase 2
22 Hypolipidemic Agents Phase 1, Phase 2
23 Hypoglycemic Agents Phase 1, Phase 2
24 Antimetabolites Phase 1, Phase 2
25 Anticoagulants Phase 1, Phase 2
26 Fibrinolytic Agents Phase 1, Phase 2
27 Lipid Regulating Agents Phase 1, Phase 2
28
Levobupivacaine Approved, Investigational Not Applicable 27262-47-1 92253
29
Temazepam Approved, Investigational Not Applicable 846-50-4 5391
30
Atracurium Approved, Experimental, Investigational Not Applicable 64228-79-1 47319
31
Propofol Approved, Investigational, Vet_approved Not Applicable 2078-54-8 4943
32
Bupivacaine Approved, Investigational Not Applicable 2180-92-9, 38396-39-3 2474
33
Fentanyl Approved, Illicit, Investigational, Vet_approved Not Applicable 437-38-7 3345
34
Dexmedetomidine Approved, Vet_approved Not Applicable 113775-47-6 68602 5311068
35 Anesthetics Not Applicable
36 Antibiotics, Antitubercular Not Applicable
37 Anti-Bacterial Agents Not Applicable
38 Nucleic Acid Synthesis Inhibitors Not Applicable
39 Mitomycins Not Applicable
40 Alkylating Agents Not Applicable
41 Anesthetics, Local Not Applicable
42 Central Nervous System Depressants Not Applicable
43 Adrenergic Agents Not Applicable
44 Analgesics Not Applicable
45 Neurotransmitter Agents Not Applicable
46 Adrenergic alpha-Agonists Not Applicable
47 Adrenergic alpha-2 Receptor Agonists Not Applicable
48 Analgesics, Non-Narcotic Not Applicable
49 Adrenergic Agonists Not Applicable
50 Hypnotics and Sedatives Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients Completed NCT02855502 Phase 4 Prednisolone;Placebo
2 Airway and/or Pulmonary Vessels Transplantation Recruiting NCT01331863 Phase 1, Phase 2
3 Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells Active, not recruiting NCT03130374 Phase 1, Phase 2
4 Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants Withdrawn NCT01977911 Phase 1, Phase 2
5 A Study to Assess the Safety, Tolerability and Potential Efficacy of a Tracheal Replacement Consisting of a Tissue-engineered Tracheal Scaffold With Seeded Mesenchymal Cells Suspended NCT02949414 Phase 1
6 A Clinical Trial on Effectiveness and Safety of Hydrogen Generator to Treat Dyspnea for the Patients With Tracheal Stenosis: A Randomized, Double-blind and Single-center Clinical Study Unknown status NCT02961387 Not Applicable
7 Biodegradable Stents in the Management of Stenoses of the Large Airways Unknown status NCT02620319 Not Applicable
8 Study of Mitomycin-C Application in Laryngotracheal Stenosis Unknown status NCT01523275 Not Applicable Mitomycin -C
9 Local Wound Infiltration for Tracheal Reconstruction Unknown status NCT02949661 Not Applicable
10 Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis Completed NCT00705848
11 Modified Endotracheal Balloon Dilator to Improve Patient Oxygenation and Allow Ventilation During Airway Procedures Completed NCT02796326 Not Applicable
12 Estimation of Intrinsic Positive End-Expiratory Pressure (PEEP) in Acute Respiratory Distress Syndrome (ARDS) Completed NCT00446706
13 Factors to Obstructive Granulation Tissue Formation After Ultraflex Stenting in Benign Tracheal Narrowing Completed NCT01006200
14 Gold Laser Vs. Micro-Debriders for Functional Endoscopic Sinus Surgery Recruiting NCT02900794 Not Applicable
15 Brainstem Dysfunction Involvement in the Pathogenesis of Pierre Robin Sequence Recruiting NCT03423017 Not Applicable
16 Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients Recruiting NCT03455881
17 trūFreeze® Spray Cryotherapy Patient Registry Active, not recruiting NCT01802203
18 Endotracheal Dilator to Improve Oxygenation Not yet recruiting NCT03411928 Not Applicable
19 Dexmedetomidine for Bilateral Superficial Cervical Plexus Block for Reconstructive Tracheal Surgery Not yet recruiting NCT03426527 Not Applicable Levobupivacaine;Levobupivacaine-Dexmedetomidine
20 MRI Review of Tracheal Dimensions Terminated NCT00277953
21 Ventilator Associated Pneumonia and Late Complications of Percutaneous Tracheostomy Terminated NCT00184925 Not Applicable
22 Office-based Radial Expansion Balloon Dilation of the Esophagus and Trachea Withdrawn NCT00583960

Search NIH Clinical Center for Tracheal Stenosis

Cochrane evidence based reviews: tracheal stenosis

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Genetic Tests for Tracheal Stenosis

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Genetic tests related to Tracheal Stenosis:

# Genetic test Affiliating Genes
1 Tracheal Stenosis 29
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Anatomical Context for Tracheal Stenosis

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MalaCards organs/tissues related to Tracheal Stenosis:

41
Trachea, Lung, Heart, Thyroid, T Cells, B Cells, Myeloid
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Publications for Tracheal Stenosis

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Articles related to Tracheal Stenosis:

(show top 50) (show all 918)
# Title Authors Year
1
Difficulty in tracheal extubation followed by tracheal collapse after balloon dilatation for tracheal stenosis therapy: A case report. ( 29851818 )
2018
2
Tracheal stenosis-resection and reconstruction. ( 29707510 )
2018
3
Cervical Tracheal Resection and Anastomosis for Postintubation Tracheal Stenosis. ( 29742573 )
2018
4
Endoscopic and Surgical Treatment of Benign Tracheal Stenosis: A Multidisciplinary Team Approach. ( 29877219 )
2018
5
Anesthetic Management for Concomitant Correction of Congenital Cardiac Defects and Long "O" Ring Tracheal Stenosis: A Role for Heliox?: Report of 2 Cases. ( 29611831 )
2018
6
Successful Use of Aortic Homograft for Residual Tracheal Stenosis Following Slide Tracheoplasty. ( 29518535 )
2018
7
Intubation in two patients with difficult airway management and tracheal stenosis after tracheostomy in thoracic surgery. ( 29429553 )
2018
8
Impact of 3D printing on the surgical management of tracheal stenosis associated to pulmonary sling: a case report. ( 29607202 )
2018
9
Ventilation strategy and anesthesia management in patients with severe tracheal stenosis undergoing urgent tracheal stenting. ( 29315465 )
2018
10
Erythromycin combined with corticosteroid reduced inflammation and modified trauma-induced tracheal stenosis in a rabbit model. ( 29781361 )
2018
11
Unexpected Exacerbation of Tracheal Stenosis in a Patient with Hunter Syndrome Undergoing Cardiac Surgery. ( 29862088 )
2018
12
High-flow nasal cannula oxygenation during interventional bronchoscopy in a patient with severe tracheal stenosis. ( 29428824 )
2018
13
Two Bronchogenic Cysts Causing Tracheal Stenosis in an Infant. ( 29099998 )
2018
14
Incidental Diagnosis of Congenital Tracheal Stenosis in Children With Congenital Heart Disease Presenting for Cardiac Surgery. ( 29753667 )
2018
15
A novel simple external fixation for securing silicone stent in patients with upper tracheal stenosis. ( 29707372 )
2018
16
Functional outcome after (laryngo)tracheal resection and reconstruction for acquired benign (laryngo)tracheal stenosis. ( 29707500 )
2018
17
Successful Treatment of Life-threatening Tracheal Stenosis Caused by Malignancy with a Self-expanding Hybrid Stent. ( 29093400 )
2018
18
Difficult intubation due to unknown congenital tracheal stenosis in the adult: a case report and literature review. ( 29607194 )
2018
19
Role of the impulse oscillometry in the evaluation of tracheal stenosis. ( 29627402 )
2018
20
Bronchial Mismatch as a Predictor of Respiratory Failure After Congenital Tracheal Stenosis Repair. ( 29397926 )
2018
21
Surgical management of children presenting with surgical-needed tracheal stenosis. ( 29605358 )
2018
22
Profilactic role of simvastatin and mitomycin C in tracheal stenosis after tracheal damage: Study in rats. ( 29447825 )
2018
23
Pitfalls in the management of congenital tracheal stenosis: is conservative management feasible? ( 30099581 )
2018
24
Congenital tracheal stenosis: what should we look at for successful tracheoplasty? ( 30159250 )
2018
25
Fluid dynamic assessment of tracheal flow in infants with congenital tracheal stenosis before and after surgery. ( 30421262 )
2018
26
Life-threatening giant esophageal neurofibroma with severe tracheal stenosis: a case report. ( 30178113 )
2018
27
Tracheal A-frame Deformity: A Challenging Variant of Tracheal Stenosis. ( 29394162 )
2018
28
Anesthetic Management in Tracheal Dilatation for Severe Tracheal Stenosis. ( 29961932 )
2018
29
Holmium Laser for Endoscopic Treatment of Benign Tracheal Stenosis. ( 29983755 )
2018
30
Iatrogenic Tracheal Stenosis After Yasui Operation in a Neonate With Aortic Atresia and Type B Aortic Interruption. ( 30122613 )
2018
31
Risk Factors for Posttracheostomy Tracheal Stenosis. ( 30130451 )
2018
32
Use of dedicated optical tracheal dilator for postintubation tracheal stenosis: First report from India. ( 30168462 )
2018
33
Idiopathic cervical tracheal stenosis in an 11-year-old male. ( 30174014 )
2018
34
Breathing Hydrogen-Oxygen Mixture Decreases Inspiratory Effort in Patients with Tracheal Stenosis. ( 30227423 )
2018
35
Endobronchial Ultrasound for Benign Tracheal Stenosis. ( 30231264 )
2018
36
Health-related quality of life evaluation in patients with non-surgical benign tracheal stenosis. ( 30233850 )
2018
37
Metallic stent insertion and removal for post-tracheotomy and post-intubation tracheal stenosis. ( 30357596 )
2018
38
Resection and Reconstruction of the Trachea for the Treatment of Upper Tracheal Stenosis: Tracheal Versus Non-Tracheal Intubation. ( 30369384 )
2018
39
Jet ventilation in obese patients undergoing airway surgery for subglottic and tracheal stenosis. ( 29288493 )
2017
40
Membranous tracheal stenosis in a patient with anorexia nervosa and self-induced vomiting- challenges in securing the airway. ( 28377879 )
2017
41
Left pulmonary artery sling and congenital tracheal stenosis: to slide or not to slide? ( 29312682 )
2017
42
Partial cricotracheal resection for severe upper tracheal stenosis: Potential impacts on the outcome. ( 28363712 )
2017
43
Maintenance of balance between airway pressure and intracranial pressure in a patient with tracheal stenosis undergoing craniotomy: a case report. ( 28017177 )
2017
44
The Relationship between Body Mass, Tracheal Diameter, Endotracheal Tube Size, and Tracheal Stenosis. ( 27930416 )
2017
45
A canine model of tracheal stenosis induced by cuffed endotracheal intubation. ( 28349955 )
2017
46
Resection and anastomosis for benign tracheal stenosis: Single institution experience of 18 cases. ( 28869225 )
2017
47
An Adolescent with Dyspnea and Cough. A Case of Congenital Tracheal Stenosis. ( 28683205 )
2017
48
Item Selection and Content Validity of the Risk Factors of Post-Intubation Tracheal Stenosis Observation Questionnaire for ICU-Admitted Patients. ( 28638421 )
2017
49
Concentric photothermal coagulation with basket-integrated optical device for treatment of tracheal stenosis. ( 28731623 )
2017
50
Clinical implications of differentiating between types of post-tracheostomy tracheal stenosis. ( 29268510 )
2017
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Variations for Tracheal Stenosis

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Expression for Tracheal Stenosis

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Search GEO for disease gene expression data for Tracheal Stenosis.
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Pathways for Tracheal Stenosis

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Pathways related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
O-glycosylation of TSR domain-containing proteins 66
Show member pathways
 10.84 ADAMTS10 ADAMTSL2
2
Elastic fibre formation 66
Show member pathways
 10.49 FBN1 LTBP3
Sources

GO Terms for Tracheal Stenosis

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Cellular components related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microfibril GO:0001527 8.96 ADAMTS10 FBN1
2 extracellular matrix GO:0031012 8.92 ADAMTS10 ADAMTSL2 FBN1 LTBP3
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Sources for Tracheal Stenosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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