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MCID: TRC005
MIFTS: 38

Tracheal Stenosis

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Tracheal Stenosis

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MalaCards integrated aliases for Tracheal Stenosis:

Name: Tracheal Stenosis 12 29 15 71
Stenosis of Trachea 12

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3227
NCIt 49 C78646
SNOMED-CT 67 11296007
UMLS 71 C0040583
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Summaries for Tracheal Stenosis

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MalaCards based summary : Tracheal Stenosis, also known as stenosis of trachea, is related to geleophysic dysplasia 3 and geleophysic dysplasia 1. An important gene associated with Tracheal Stenosis is ADAMTSL2 (ADAMTS Like 2), and among its related pathways/superpathways are O-linked glycosylation and Diseases of glycosylation. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include trachea, lung and heart.

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Related Diseases for Tracheal Stenosis

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Diseases related to Tracheal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
# Related Disease Score Top Affiliating Genes
1 geleophysic dysplasia 3 32.4 TBRG1 LTBP3 ADAMTSL2
2 geleophysic dysplasia 1 32.4 TBRG1 LTBP3 FBN1 ADAMTSL2
3 geleophysic dysplasia 2 32.2 TBRG1 LTBP3 FBN1 ADAMTSL2
4 geleophysic dysplasia 31.3 TBRG1 LTBP3 FBN1 ADAMTSL4 ADAMTSL2 ADAMTS17
5 mediastinitis 30.8 TEF RHNO1
6 aspiration pneumonia 29.9 TEF SLC22A4
7 aortic aneurysm, familial thoracic 1 29.6 TGFB3 LTBP3 FBN1
8 tracheomalacia 29.6 TEF SLC22A4 RHNO1 OSR1 LRRC1 GALNS
9 aortic dissection 29.5 TGFB3 FBN1
10 tracheal disease 26.9 TEF TBRG1 SLC22A4 RHNO1 PRTN3 PLCL1
11 idiopathic subglottic tracheal stenosis 12.6
12 anterior chamber cleavage disorder, cerebellar hypoplasia, hypothyroidism, and tracheal stenosis 12.4
13 tracheobronchial stenosis, congenital 11.9
14 respiratory failure 10.6
15 tracheoesophageal fistula with or without esophageal atresia 10.5
16 thyroid carcinoma 10.4
17 tetralogy of fallot 10.4
18 esophageal atresia 10.4
19 goiter 10.4
20 esophageal cancer 10.3
21 heart septal defect 10.3
22 autosomal recessive cutis laxa type i 10.3 LTBP3 FBN1
23 aspiration pneumonitis 10.3 TEF SLC22A4
24 ventricular septal defect 10.3
25 relapsing polychondritis 10.3
26 sclerosing keratitis 10.3 TEF PRTN3
27 deep keratitis 10.3 TEF PRTN3
28 ethmoid sinusitis 10.3 RHNO1 PRTN3
29 orbital plasma cell granuloma 10.3 RHNO1 PRTN3
30 hernia, hiatus 10.3 TEF SLC22A4
31 gastroesophageal reflux 10.3
32 pulmonary hypoplasia, primary 10.3
33 chronic orbital inflammation 10.3 RHNO1 PRTN3
34 multiple cranial nerve palsy 10.2 RHNO1 PRTN3
35 cranial nerve palsy 10.2 RHNO1 PRTN3
36 glossopharyngeal nerve disease 10.2 RHNO1 PRTN3
37 cyanosis, transient neonatal 10.2
38 cardiac arrest 10.2
39 bronchitis 10.2
40 double outlet right ventricle 10.2
41 dysphagia 10.2
42 phacogenic glaucoma 10.2 LTBP3 FBN1
43 sphenoid sinusitis 10.2 RHNO1 LRRC1
44 primary congenital glaucoma 10.2 LTBP3 FBN1 ADAMTS10
45 down syndrome 10.2
46 tracheobronchomalacia 10.2
47 central retinal artery occlusion 10.2 RHNO1 PRTN3
48 mucopolysaccharidosis, type ii 10.2
49 patent ductus arteriosus 1 10.2
50 granulomatosis with polyangiitis 10.2

Graphical network of the top 20 diseases related to Tracheal Stenosis:



Diseases related to Tracheal Stenosis
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Symptoms & Phenotypes for Tracheal Stenosis

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Drugs & Therapeutics for Tracheal Stenosis

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Drugs for Tracheal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
6
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
7 Antineoplastic Agents, Hormonal Phase 4
8 Methylprednisolone Acetate Phase 4
9
Azithromycin Approved Phase 1, Phase 2 83905-01-5 447043 55185
10
Budesonide Approved Phase 1, Phase 2 51333-22-3 63006 5281004
11 Hormones Phase 1, Phase 2
12 Hormone Antagonists Phase 1, Phase 2
13 glucocorticoids Phase 1, Phase 2
14 Anti-Inflammatory Agents Phase 1, Phase 2
15 Anti-Bacterial Agents Phase 1, Phase 2
16 Respiratory System Agents Phase 1, Phase 2
17 Anti-Infective Agents Phase 1, Phase 2
18 Anti-Asthmatic Agents Phase 1, Phase 2
19 Bronchodilator Agents Phase 1, Phase 2
20
Levobupivacaine Approved, Investigational 27262-47-1 92253
21
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
22
Dexmedetomidine Approved, Vet_approved 113775-47-6 5311068 68602
23
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
24
Atracurium Approved, Experimental, Investigational 64228-79-1 47319
25 Adrenergic alpha-Agonists
26 Hypnotics and Sedatives
27 Adrenergic Agents
28 Analgesics, Non-Narcotic
29 Adrenergic Agonists
30 Analgesics
31 Neurotransmitter Agents
32 Ulipristal acetate 126784-99-4
33 Alkylating Agents
34 Antibiotics, Antitubercular
35 Mitomycins

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients Completed NCT02855502 Phase 4 Prednisolone;Placebo
2 Impedance Cardiography: Clinical Evaluation of Endotracheal Cardiac Output Monitor (ECOM) Completed NCT00924482 Phase 2, Phase 3
3 Replacement of the Airways and/or the Pulmonary Vessels Using a Cryopreserved Arterial Allograft Unknown status NCT01331863 Phase 1, Phase 2
4 Treatment of Laryngotracheal Stenosis Using Autologous Olfactory-mucosa-derived Mesenchymal Stem Cells Completed NCT03130374 Phase 1, Phase 2
5 Incidence of Acute Laryngeal Injury Following Endotracheal Intubation Recruiting NCT03250975 Phase 1, Phase 2 Budesonide and Azithromycin
6 Phase I/IIa Clinical Trial of Stem Cell Based Tissue Engineered Partial Laryngeal Implants in 10 Adult Patients With End-stage Laryngeal Stenosis With 24 Months Follow-up. Withdrawn NCT01977911 Phase 1, Phase 2
7 A Phase I Open-label Study to Assess the Safety, Tolerability and Potential Efficacy of a Novel Tracheal Replacement Consisting of a Tissue-engineered Decellularised Tracheal Scaffold With Seeded Autologous Mesenchymal Cells in Subjects With Severe Tracheal Stenosis or Malacia Suspended NCT02949414 Phase 1
8 A Clinical Trial on Effectiveness and Safety of Inhaling Hydrogen-oxygen to Decreases Inspiratory Effort for the Patients With Tracheal Stenosis: A Randomized, Double-blind and Single-center Clinical Study Unknown status NCT02961387
9 Local Wound Infiltration Versus Bilateral Superficial Cervical Plexus Block With Levobupivacaine for Upper Tracheal Resection and Reconstruction Surgery Under General Anesthesia. Unknown status NCT02949661
10 Levobupivacaine Versus Levobupivacaine - Dexmedetomidine for Ultrasound Guided Bilateral Superficial Cervical Plexus Block for Upper Tracheal Resection and Reconstruction Surgery Under General Anesthesia Unknown status NCT03426527 Levobupivacaine;Levobupivacaine-Dexmedetomidine
11 Maximal Effort-dependent Respiratory Flow Rates: Reproducibility and Reference Values Unknown status NCT03197701
12 Modified Endotracheal Balloon Dilator to Improve Oxygenation During Airway Procedures in Children With Tracheal Stenosis Unknown status NCT03411928
13 Biodegradable Stents in the Management of Stenoses of the Large Airways Unknown status NCT02620319
14 A Comparison of CPAP Delivered by Helmet and O2 Therapy With a Venturi Mask as First Line Intervention in Early ALI/ARDS Unknown status NCT00342368
15 Modified Endotracheal Balloon Dilator to Improve Patient Oxygenation and Allow Ventilation During Airway Procedures Completed NCT02796326
16 Factors to Obstructive Granulation Tissue Formation After Ultraflex Stenting in Benign Tracheal Narrowing Completed NCT01006200
17 Relationship Between Tracheal and Left Pulmonary Artery Stenosis Index and Prognosis of Pulmonary Artery Sling With Tracheal Stenosis Completed NCT04383184
18 Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis Completed NCT00705848
19 Mechanical Ventilation in Patients With \Respiratory Failure: A Comparison of Face Mask and Non Invasive Ventilation Via a Helmet Device Completed NCT01680783
20 The Changes of Endotracheal Tube Cuff Pressures After Ear, Head and Neck Surgery-Related Positions: A Prospective Observational Study Completed NCT04037553
21 F.R.O.N.T. Formula for Pre-operative Airway Assessment and Documentation Completed NCT02313168
22 Reducing Intra-operative Pressure Variations in Paediatric Microcuff Endotracheal Tube Cuffs Completed NCT03240354
23 The Effects of High-flow Nasal Oxygen on Oxygenation During Rigid Bronchoscopy Under General Anesthesia in Pediatric Patients: A Prospective Observational Pilot Study Recruiting NCT03905733
24 Covered Metallic Segmented Airway Stent Modified With 3D Printing for Malignant Stricture Involving Carina and Bronchi Distal to Carina: A Multicenter Study Recruiting NCT03890575
25 Comprehensive Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients Recruiting NCT03455881
26 Treatment Alternatives in Adult Rare Disease; Assessment of Options in Idiopathic Subglottic Stenosis North American Airway Collaborative PR-02 Study (NoAAC PR-02 Study) Active, not recruiting NCT02481817
27 Electrical Stimulation of Laryngeal Muscles to Restore Glottal Opening in Patients With Bilateral Vocal Fold Paralysis Active, not recruiting NCT03085316
28 trūFreeze® Spray Cryotherapy Patient Registry Active, not recruiting NCT01802203
29 Functional Electrical Stimulation of the Bilaterally Paralyzed Human Larynx Not yet recruiting NCT04028674
30 A Review of Tracheal Dimensions in the Pediatric Population Using MRI Terminated NCT00277953
31 A Randomized Study of Mitomycin-C Application in the Endoscopic Surgical Treatment of Patients With Laryngotracheal Stenosis Terminated NCT01523275 Mitomycin -C
32 Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis Refractory to Endoscopic Treatment With Dilatation in Patients With Head and Neck Cancer Terminated NCT03540953 Endoscopic injection of Mitomycin C
33 Office-based Radial Expansion Balloon Dilation of the Esophagus and Trachea Withdrawn NCT00583960
34 Comparing Post-Operative Outcomes Between Gold Laser and Micro-Debriders for Functional Endoscopic Sinus Surgery (FESS) in Patients With Chronic Sinusitis Withdrawn NCT02900794

Search NIH Clinical Center for Tracheal Stenosis

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Genetic Tests for Tracheal Stenosis

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Genetic tests related to Tracheal Stenosis:

# Genetic test Affiliating Genes
1 Tracheal Stenosis 29
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Anatomical Context for Tracheal Stenosis

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MalaCards organs/tissues related to Tracheal Stenosis:

40
Trachea, Lung, Heart, Thyroid, Testes, Lymph Node, Spinal Cord
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Publications for Tracheal Stenosis

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Articles related to Tracheal Stenosis:

(show top 50) (show all 2806)
# Title Authors PMID Year
1
Diagnosis and management of complete tracheal rings with concurrent tracheoesophageal fistula. 61
32179205 2020
2
Surgical Closure of Tracheoesophageal Puncture Without a Flap Interposition. 61
32513063 2020
3
Staging of Surgical Procedures in Comorbid Congenital Tracheal Stenosis and Congenital Cardiovascular Disease. 61
32119856 2020
4
Dilation of tracheal stenosis below tracheostomy tube with Dolphin percutaneous tracheostomy kit : Tracheal stenosis treated with Dolphin PDT. 61
32048145 2020
5
Transnasal humidified rapid-insufflation ventilatory exchange can be utilized in tracheal stenosis caused by thyroid tumor. 61
31951920 2020
6
Postintubation Tracheal Stenosis Evaluated by Endobronchial Optical Coherence Tomography: A Canine Model Study. 61
32485723 2020
7
Late presentation of Long Segment Tracheal Stenosis with Complete Tracheal Rings. 61
32502477 2020
8
Tracheoplasty for Patients with Pulmonary Artery Sling and Tracheal Stenosis: A Meta-Analysis. 61
32494877 2020
9
Bioinformatics analysis and verification of gene targets for benign tracheal stenosis. 61
32309912 2020
10
Anti-fibrosis activity of quercetin attenuates rabbit tracheal stenosis via the TGF-β/AKT/mTOR signaling pathway. 61
32179074 2020
11
Emergency tracheotomy and subsequent tracheal resection and anastomosis in a blue crane (Anthropoides paradiseus). 61
32412868 2020
12
Perioperative outcomes after tracheoplasty: A NSQIP analysis 2014-2016. 61
31498450 2020
13
Improving Endotracheal Cuff Inflation Pressures: An Evidence-Based Project in a Military Medical Center. 61
32442097 2020
14
Prolonged endotracheal intubation: a feasible option for tracheomalacia after retrosternal goitre surgery. 61
32527127 2020
15
Tracheal Reconstruction Surgery Supported by Extracorporeal Membrane Oxygenation for Patients with Traumatic Post-tracheotomy Tracheal Stenosis. 61
32475889 2020
16
Classification of tracheal stenosis in children based on computational aerodynamics. 61
32224051 2020
17
The suction-assisted endoscopic suture technique: A simple method for endotracheal suturing. 61
31373680 2020
18
Risk factors for decannulation failure after single-stage reconstruction of adult post-intubation tracheal stenosis: 10-year experience at a tertiary center. 61
32003273 2020
19
From Tracheal Stenosis to Tracheostomy Displacement: A Case Report on a Seemingly Never-Ending Difficult Airway. 61
32224697 2020
20
Difficult intubation and anesthetic management in an adult patient with undiagnosed congenital tracheal stenosis: a case report. 61
32321342 2020
21
Idiopathic Subglottic Tracheal Stenosis Misdiagnosed As Vocal Cord Dysfunction and Successfully Treated with Laser and Controlled Radial Expansion Balloon Dilation. 61
32431981 2020
22
Fabrication and biological activity of polycaprolactone/phlorotannin endotracheal tube to prevent tracheal stenosis: An in vitro and in vivo study. 61
31392823 2020
23
Spontaneous bag mask ventilation for establishing cardiopulmonary bypass via mid-sternotomy in patients with severe tracheal stenosis: A series of three patients. 61
32275048 2020
24
Postoperative respiratory complications and disposition in patients with type 1 laryngeal clefts undergoing injection or repair - A single institution experience. 61
31901483 2020
25
Congenital tracheal stenosis & associated cardiac anomalies: operative management & techniques. 61
32274199 2020
26
Clinical and structural aspects of tracheal stenosis and a novel embryological hypothesis of left pulmonary artery sling. 61
31975532 2020
27
Postintubation tracheal stenosis. 61
32164999 2020
28
Cryotherapy ablation in Immunoglobulin G4-Related Disease of the Trachea. 61
32135154 2020
29
A promising treatment of tracheal stenosis in critically ill patients. 61
32152954 2020
30
Benign Tracheal Stenosis: 7 Years of Follow-up Tracheal Stenting. 61
31006499 2020
31
Tracheal Bridge for Reconstruction of the Upper Airway in Double Tracheal Stenosis. 61
31557483 2020
32
The prefabricated supraclavicular artery flap in high-risk tracheal stenosis patients. 61
31112334 2020
33
Evaluation of Cilia Function in Rat Trachea Reconstructed Using Collagen Sponge Scaffold Seeded with Adipose Tissue-Derived Stem Cells. 61
30809962 2020
34
Slide tracheoplasty: Predictors of outcomes and literature review. 61
31862500 2020
35
Treatment strategy for severe airway stenosis due to a thoracic aortic aneurysm. 61
32114045 2020
36
The role of 3D printing in pediatric airway obstruction: A systematic review. 61
32035351 2020
37
Surgical repair of mechanical ventilation induced tracheoesophageal fistula. 61
31705278 2020
38
[Effect of partial cricotracheal resection and extended cricotracheal resection for severe laryngotracheal stenosis]. 61
32074745 2020
39
Morphologic Analysis of Congenital Heart Disease With Anomalous Tracheobronchial Arborization. 61
32114043 2020
40
[Surgical treatment of acquired tracheal stenosis in pediatrics]. 61
31984715 2020
41
Postintubation tracheal stenosis 35 years after neonatal resuscitation. 61
32487473 2020
42
Challenging tracheal resection anastomosis: Case series. 61
32035696 2020
43
Biodegradable electrospun patch containing cell adhesion or antimicrobial compounds for trachea repair in vivo. 61
31791031 2020
44
Preoperative Assessment of Airway Patency During General Anesthesia in a Patient With Severe Tracheal Stenosis: Effectiveness of Noninvasive Positive Pressure Ventilation. 61
31345712 2020
45
Delay between onset of indication and definitive surgery for tracheal trauma. 61
31981348 2020
46
Outcome of congenital tracheal stenosis in children over two decades in a national cardiothoracic surgical unit. 61
31744583 2020
47
Computational Evaluation of Surgical Design for Multisegmental Complex Congenital Tracheal Stenosis. 61
32382545 2020
48
Tracheoplasty for Congenital Tracheal Stenosis with Bilateral Tracheal Bronchus. 61
31996506 2020
49
[Etiology, diagnosis and treatment of cicatricial tracheal stenosis]. 61
32352669 2020
50
[Circular resection of the thoracic trachea for MALT lymphoma in an 81-year-old patient]. 61
32500697 2020
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Variations for Tracheal Stenosis

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Expression for Tracheal Stenosis

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Search GEO for disease gene expression data for Tracheal Stenosis.
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Pathways for Tracheal Stenosis

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Pathways related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
O-linked glycosylation 65
Show member pathways
 11.72 ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10
2
Diseases of glycosylation 65
Show member pathways
 11.42 ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10
3
Elastic fibre formation 65
Show member pathways
 11.3 TGFB3 LTBP3 FBN1
4
O-glycosylation of TSR domain-containing proteins 65
Show member pathways
 10.81 ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10
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GO Terms for Tracheal Stenosis

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Cellular components related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 TGFB3 PRTN3 LTBP3 GALNS FBN1 ADAMTSL4
2 extracellular matrix GO:0031012 9.35 FBN1 ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10
3 microfibril GO:0001527 9.26 FBN1 ADAMTS10
4 collagen-containing extracellular matrix GO:0062023 9.1 TGFB3 PRTN3 LTBP3 FBN1 ADAMTSL4 ADAMTS10

Biological processes related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.35 PRTN3 ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10
2 extracellular matrix organization GO:0030198 9.02 FBN1 ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10

Molecular functions related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.35 PRTN3 ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10
2 transforming growth factor beta binding GO:0050431 9.16 TGFB3 LTBP3
3 metalloendopeptidase activity GO:0004222 8.92 ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10
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Sources for Tracheal Stenosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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