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MCID: TRC005
MIFTS: 39

Tracheal Stenosis

Categories: Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Tracheal Stenosis

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MalaCards integrated aliases for Tracheal Stenosis:

Name: Tracheal Stenosis 12 30 45 15 74
Stenosis of Trachea 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3227
MeSH 45 D014135
NCIt 51 C78646
SNOMED-CT 69 11296007
UMLS 74 C0040583
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Summaries for Tracheal Stenosis

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MalaCards based summary : Tracheal Stenosis, also known as stenosis of trachea, is related to tracheomalacia and pneumothorax. An important gene associated with Tracheal Stenosis is ADAMTSL2 (ADAMTS Like 2), and among its related pathways/superpathways are O-glycosylation of TSR domain-containing proteins and Elastic fibre formation. The drugs Prednisolone phosphate and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include trachea, thyroid and lymph node, and related phenotype is mortality/aging.

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Related Diseases for Tracheal Stenosis

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Diseases in the Tracheal Stenosis family:

Congenital Tracheal Stenosis

Diseases related to Tracheal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 tracheomalacia 30.5 SLC22A4 TEF
2 pneumothorax 29.6 FBN1 SLC22A4
3 idiopathic subglottic tracheal stenosis 12.4
4 congenital tracheal stenosis 12.4
5 anterior chamber cleavage disorder, cerebellar hypoplasia, hypothyroidism, and tracheal stenosis 12.2
6 tracheobronchial stenosis, congenital 11.7
7 geleophysic dysplasia 1 11.4
8 jung wolff back stahl syndrome 11.2
9 geleophysic dysplasia 2 11.2
10 geleophysic dysplasia 3 11.2
11 geleophysic dwarfism 11.2
12 heart disease 10.3
13 asthma 10.2
14 tracheoesophageal fistula 10.2
15 acromicric dysplasia 10.2 FBN1 LTBP3
16 lung agenesis 10.1
17 esophageal cancer 10.1
18 tracheoesophageal fistula with or without esophageal atresia 10.1
19 down syndrome 10.1
20 esophageal atresia 10.1
21 goiter 10.1
22 trachea leiomyoma 10.0 SLC22A4 TEF
23 tetralogy of fallot 10.0
24 tracheopathia osteoplastica 10.0
25 lung cancer 10.0
26 mucopolysaccharidosis, type ii 10.0
27 respiratory failure 10.0
28 thyroid cancer 10.0
29 relapsing polychondritis 10.0
30 mediastinitis 10.0
31 fibrosing mediastinitis 10.0
32 diaphragmatic eventration 10.0 FBN1 TEF
33 geleophysic dysplasia 10.0 ADAMTSL2 FBN1 LTBP3
34 burns 9.9
35 lymphoma 9.9
36 isolated ectopia lentis 9.9 ADAMTS10 ADAMTSL2 FBN1
37 weill-marchesani syndrome 9.9 ADAMTS10 ADAMTSL2 FBN1
38 peters-plus syndrome 9.8 ADAMTS10 ADAMTSL2
39 pfeiffer syndrome 9.8
40 systemic lupus erythematosus 9.8
41 pectus excavatum 9.8
42 rheumatoid arthritis 9.8
43 small cell cancer of the lung 9.8
44 autism 9.8
45 chondrodysplasia punctata syndrome 9.8
46 corpus callosum, agenesis of, with facial anomalies and robin sequence 9.8
47 mowat-wilson syndrome 9.8
48 myasthenia gravis 9.8
49 anorexia nervosa 9.8
50 patent ductus arteriosus 1 9.8

Graphical network of the top 20 diseases related to Tracheal Stenosis:



Diseases related to Tracheal Stenosis
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Symptoms & Phenotypes for Tracheal Stenosis

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MGI Mouse Phenotypes related to Tracheal Stenosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.17 ADAMTSL2 FBN1 LTBP3 PGRMC1 POC1A SLC22A4
Sources

Drugs & Therapeutics for Tracheal Stenosis

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Drugs for Tracheal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
6 Peripheral Nervous System Agents Phase 4,Not Applicable
7 Prednisolone acetate Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Hormones Phase 4
10 Autonomic Agents Phase 4
11 Antineoplastic Agents, Hormonal Phase 4
12 Hormone Antagonists Phase 4
13 Antiemetics Phase 4
14 Methylprednisolone Acetate Phase 4
15 Neuroprotective Agents Phase 4
16 Gastrointestinal Agents Phase 4
17 glucocorticoids Phase 4
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
19 Protective Agents Phase 4
20
Levobupivacaine Approved, Investigational Not Applicable 27262-47-1 92253
21
Temazepam Approved, Investigational Not Applicable 846-50-4 5391
22
Atracurium Approved, Experimental, Investigational Not Applicable 64228-79-1 47319
23
Dexmedetomidine Approved, Vet_approved Not Applicable 113775-47-6 68602 5311068
24
Fentanyl Approved, Illicit, Investigational, Vet_approved Not Applicable 437-38-7 3345
25
Propofol Approved, Investigational, Vet_approved Not Applicable 2078-54-8 4943
26 Ulipristal acetate Not Applicable 126784-99-4
27 Anesthetics Not Applicable
28 Mitomycins Not Applicable
29 Anti-Bacterial Agents Not Applicable
30 Nucleic Acid Synthesis Inhibitors Not Applicable
31 Alkylating Agents Not Applicable
32 Antibiotics, Antitubercular Not Applicable
33 Central Nervous System Depressants Not Applicable
34 Anesthetics, Local Not Applicable
35 Adrenergic alpha-2 Receptor Agonists Not Applicable
36 Neurotransmitter Agents Not Applicable
37 Adrenergic Agonists Not Applicable
38 Adrenergic alpha-Agonists Not Applicable
39 Adrenergic Agents Not Applicable
40 Analgesics Not Applicable
41 Analgesics, Non-Narcotic Not Applicable
42 Hypnotics and Sedatives Not Applicable
43 Calamus Not Applicable

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients Completed NCT02855502 Phase 4 Prednisolone;Placebo
2 Airway and/or Pulmonary Vessels Transplantation Recruiting NCT01331863 Phase 1, Phase 2
3 Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells Active, not recruiting NCT03130374 Phase 1, Phase 2
4 Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants Withdrawn NCT01977911 Phase 1, Phase 2
5 A Study to Assess the Safety, Tolerability and Potential Efficacy of a Tracheal Replacement Consisting of a Tissue-engineered Tracheal Scaffold With Seeded Mesenchymal Cells Suspended NCT02949414 Phase 1
6 A Clinical Trial on Effectiveness and Safety of Hydrogen Generator to Treat Dyspnea for the Patients With Tracheal Stenosis: A Randomized, Double-blind and Single-center Clinical Study Unknown status NCT02961387 Not Applicable
7 Biodegradable Stents in the Management of Stenoses of the Large Airways Unknown status NCT02620319 Not Applicable
8 Study of Mitomycin-C Application in Laryngotracheal Stenosis Unknown status NCT01523275 Not Applicable Mitomycin -C
9 Local Wound Infiltration for Tracheal Reconstruction Unknown status NCT02949661 Not Applicable
10 Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis Completed NCT00705848
11 Modified Endotracheal Balloon Dilator to Improve Patient Oxygenation and Allow Ventilation During Airway Procedures Completed NCT02796326 Not Applicable
12 Estimation of Intrinsic Positive End-Expiratory Pressure (PEEP) in Acute Respiratory Distress Syndrome (ARDS) Completed NCT00446706
13 Factors to Obstructive Granulation Tissue Formation After Ultraflex Stenting in Benign Tracheal Narrowing Completed NCT01006200
14 High-flow Nasal Oxygen During Rigid Bronchoscopy Under General Anesthesia: a Randomized Controlled Trial Recruiting NCT03892408 Not Applicable
15 Gold Laser Vs. Micro-Debriders for Functional Endoscopic Sinus Surgery Recruiting NCT02900794 Not Applicable
16 Brainstem Dysfunction Involvement in the Pathogenesis of Pierre Robin Sequence Recruiting NCT03423017 Not Applicable
17 Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients Recruiting NCT03455881
18 trūFreeze® Spray Cryotherapy Patient Registry Active, not recruiting NCT01802203
19 Retrievable Airway Stent Modified With 3D Printing for Benign Disease Involving Carina and Distal Bronchi Enrolling by invitation NCT03890523 Not Applicable
20 Airway Stent Modified With 3D Printing for Malignant Stricture Involving Carina and Distal Bronchi Enrolling by invitation NCT03890575 Not Applicable
21 Endotracheal Dilator to Improve Oxygenation Not yet recruiting NCT03411928 Not Applicable
22 Dexmedetomidine for Bilateral Superficial Cervical Plexus Block for Reconstructive Tracheal Surgery Not yet recruiting NCT03426527 Not Applicable Levobupivacaine;Levobupivacaine-Dexmedetomidine
23 MRI Review of Tracheal Dimensions Terminated NCT00277953
24 Ventilator Associated Pneumonia and Late Complications of Percutaneous Tracheostomy Terminated NCT00184925 Not Applicable
25 Office-based Radial Expansion Balloon Dilation of the Esophagus and Trachea Withdrawn NCT00583960

Search NIH Clinical Center for Tracheal Stenosis

Cochrane evidence based reviews: tracheal stenosis

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Genetic Tests for Tracheal Stenosis

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Genetic tests related to Tracheal Stenosis:

# Genetic test Affiliating Genes
1 Tracheal Stenosis 30
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Anatomical Context for Tracheal Stenosis

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MalaCards organs/tissues related to Tracheal Stenosis:

42
Trachea, Thyroid, Lymph Node, Spinal Cord, T Cells, Myeloid, Cortex
Sources

Publications for Tracheal Stenosis

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Articles related to Tracheal Stenosis:

(show top 50) (show all 927)
# Title Authors Year
1
Excessive tracheal length in patients with congenital tracheal stenosis. ( 30849334 )
2019
2
Tracheal Stenosis Due to IgG4-Related Fibrosing Mediastinitis. ( 30797571 )
2019
3
Postintubation tracheal stenosis: Surgical management. ( 30666033 )
2019
4
Micro-CT of tracheal stenosis in trisomy 21. ( 30712021 )
2019
5
Tracheal stenosis due to endotracheal tube cuff hyperinflation: a preventable complication. ( 30863738 )
2019
6
Difficulty in tracheal extubation followed by tracheal collapse after balloon dilatation for tracheal stenosis therapy: A case report. ( 29851818 )
2018
7
Tracheal stenosis-resection and reconstruction. ( 29707510 )
2018
8
Cervical Tracheal Resection and Anastomosis for Postintubation Tracheal Stenosis. ( 29742573 )
2018
9
Endoscopic and Surgical Treatment of Benign Tracheal Stenosis: A Multidisciplinary Team Approach. ( 29877219 )
2018
10
Anesthetic Management for Concomitant Correction of Congenital Cardiac Defects and Long "O" Ring Tracheal Stenosis: A Role for Heliox?: Report of 2 Cases. ( 29611831 )
2018
11
Successful Use of Aortic Homograft for Residual Tracheal Stenosis Following Slide Tracheoplasty. ( 29518535 )
2018
12
Intubation in two patients with difficult airway management and tracheal stenosis after tracheostomy in thoracic surgery. ( 29429553 )
2018
13
Impact of 3D printing on the surgical management of tracheal stenosis associated to pulmonary sling: a case report. ( 29607202 )
2018
14
Ventilation strategy and anesthesia management in patients with severe tracheal stenosis undergoing urgent tracheal stenting. ( 29315465 )
2018
15
Erythromycin combined with corticosteroid reduced inflammation and modified trauma-induced tracheal stenosis in a rabbit model. ( 29781361 )
2018
16
Unexpected Exacerbation of Tracheal Stenosis in a Patient with Hunter Syndrome Undergoing Cardiac Surgery. ( 29862088 )
2018
17
High-flow nasal cannula oxygenation during interventional bronchoscopy in a patient with severe tracheal stenosis. ( 29428824 )
2018
18
Two Bronchogenic Cysts Causing Tracheal Stenosis in an Infant. ( 29099998 )
2018
19
Incidental Diagnosis of Congenital Tracheal Stenosis in Children With Congenital Heart Disease Presenting for Cardiac Surgery. ( 29753667 )
2018
20
A novel simple external fixation for securing silicone stent in patients with upper tracheal stenosis. ( 29707372 )
2018
21
Functional outcome after (laryngo)tracheal resection and reconstruction for acquired benign (laryngo)tracheal stenosis. ( 29707500 )
2018
22
Successful Treatment of Life-threatening Tracheal Stenosis Caused by Malignancy with a Self-expanding Hybrid Stent. ( 29093400 )
2018
23
Difficult intubation due to unknown congenital tracheal stenosis in the adult: a case report and literature review. ( 29607194 )
2018
24
Role of the impulse oscillometry in the evaluation of tracheal stenosis. ( 29627402 )
2018
25
Bronchial Mismatch as a Predictor of Respiratory Failure After Congenital Tracheal Stenosis Repair. ( 29397926 )
2018
26
Surgical management of children presenting with surgical-needed tracheal stenosis. ( 29605358 )
2018
27
Profilactic role of simvastatin and mitomycin C in tracheal stenosis after tracheal damage: Study in rats. ( 29447825 )
2018
28
Anesthetic Management in Tracheal Dilatation for Severe Tracheal Stenosis. ( 29961932 )
2018
29
Tracheal A-frame Deformity: A Challenging Variant of Tracheal Stenosis. ( 29394162 )
2018
30
Pitfalls in the management of congenital tracheal stenosis: is conservative management feasible? ( 30099581 )
2018
31
Congenital tracheal stenosis: what should we look at for successful tracheoplasty? ( 30159250 )
2018
32
Fluid dynamic assessment of tracheal flow in infants with congenital tracheal stenosis before and after surgery. ( 30421262 )
2018
33
Life-threatening giant esophageal neurofibroma with severe tracheal stenosis: a case report. ( 30178113 )
2018
34
Holmium Laser for Endoscopic Treatment of Benign Tracheal Stenosis. ( 29983755 )
2018
35
Iatrogenic Tracheal Stenosis After Yasui Operation in a Neonate With Aortic Atresia and Type B Aortic Interruption. ( 30122613 )
2018
36
Risk Factors for Posttracheostomy Tracheal Stenosis. ( 30130451 )
2018
37
Use of dedicated optical tracheal dilator for postintubation tracheal stenosis: First report from India. ( 30168462 )
2018
38
Idiopathic cervical tracheal stenosis in an 11-year-old male. ( 30174014 )
2018
39
Breathing Hydrogen-Oxygen Mixture Decreases Inspiratory Effort in Patients with Tracheal Stenosis. ( 30227423 )
2018
40
Endobronchial Ultrasound for Benign Tracheal Stenosis. ( 30231264 )
2018
41
Health-related quality of life evaluation in patients with non-surgical benign tracheal stenosis. ( 30233850 )
2018
42
Metallic stent insertion and removal for post-tracheotomy and post-intubation tracheal stenosis. ( 30357596 )
2018
43
Resection and Reconstruction of the Trachea for the Treatment of Upper Tracheal Stenosis: Tracheal Versus Non-Tracheal Intubation. ( 30369384 )
2018
44
Nationwide estimations of tracheal stenosis due to tracheostomies. ( 30569511 )
2018
45
Prevention of tracheal stenosis with pirfenidone after tracheotomy: An experimental study. ( 30585325 )
2018
46
Mitomycin C in the endoscopic treatment of tracheal stenosis: a prospective cohort study. ( 30726324 )
2018
47
Jet ventilation in obese patients undergoing airway surgery for subglottic and tracheal stenosis. ( 29288493 )
2017
48
Membranous tracheal stenosis in a patient with anorexia nervosa and self-induced vomiting- challenges in securing the airway. ( 28377879 )
2017
49
Left pulmonary artery sling and congenital tracheal stenosis: to slide or not to slide? ( 29312682 )
2017
50
Partial cricotracheal resection for severe upper tracheal stenosis: Potential impacts on the outcome. ( 28363712 )
2017
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Variations for Tracheal Stenosis

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Expression for Tracheal Stenosis

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Search GEO for disease gene expression data for Tracheal Stenosis.
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Pathways for Tracheal Stenosis

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Pathways related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
O-glycosylation of TSR domain-containing proteins 67
Show member pathways
 10.84 ADAMTS10 ADAMTSL2
2
Elastic fibre formation 67
Show member pathways
 10.49 FBN1 LTBP3
Sources

GO Terms for Tracheal Stenosis

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Cellular components related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microfibril GO:0001527 8.96 ADAMTS10 FBN1
2 extracellular matrix GO:0031012 8.62 ADAMTSL2 FBN1
Sources

Sources for Tracheal Stenosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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