MCID: TRC005
MIFTS: 38

Tracheal Stenosis

Categories: Respiratory diseases

Aliases & Classifications for Tracheal Stenosis

MalaCards integrated aliases for Tracheal Stenosis:

Name: Tracheal Stenosis 12 29 43 15 71
Stenosis of Trachea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3227
MeSH 43 D014135
NCIt 49 C78646
SNOMED-CT 67 11296007
UMLS 71 C0040583

Summaries for Tracheal Stenosis

MalaCards based summary : Tracheal Stenosis, also known as stenosis of trachea, is related to geleophysic dysplasia and patent ductus arteriosus 1. An important gene associated with Tracheal Stenosis is ADAMTSL2 (ADAMTS Like 2), and among its related pathways/superpathways are O-linked glycosylation and Diseases of glycosylation. The drugs Prednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include trachea, thyroid and heart.

Related Diseases for Tracheal Stenosis

Diseases related to Tracheal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 297)
# Related Disease Score Top Affiliating Genes
1 geleophysic dysplasia 32.6 LTBP3 FBN1 ADAMTSL2
2 patent ductus arteriosus 1 30.5 TEF SLC22A4 FBN1
3 tracheomalacia 30.1 TEF TBX4 SLC22A4 GALNS
4 aspiration pneumonia 29.8 TEF SLC22A4
5 tracheal disease 26.4 TEF TBX4 TBRG1 SLC22A4 RHNO1 PRTN3
6 idiopathic subglottic tracheal stenosis 12.6
7 anterior chamber cleavage disorder, cerebellar hypoplasia, hypothyroidism, and tracheal stenosis 12.4
8 tracheobronchial stenosis, congenital 11.9
9 geleophysic dysplasia 1 11.5
10 geleophysic dysplasia 2 11.4
11 geleophysic dysplasia 3 11.4
12 respiratory failure 10.5
13 tracheoesophageal fistula with or without esophageal atresia 10.5
14 thyroid carcinoma 10.4
15 tetralogy of fallot 10.4
16 esophageal atresia 10.4
17 acromicric dysplasia 10.4 LTBP3 FBN1
18 goiter 10.4
19 esophageal cancer 10.3
20 heart septal defect 10.3
21 aspiration pneumonitis 10.3 TEF SLC22A4
22 ventricular septal defect 10.3
23 relapsing polychondritis 10.3
24 gastroesophageal reflux 10.2
25 pulmonary hypoplasia, primary 10.2
26 heart disease 10.2
27 phacogenic glaucoma 10.2 LTBP3 FBN1
28 cyanosis, transient neonatal 10.2
29 cardiac arrest 10.2
30 bronchitis 10.2
31 dysphagia 10.2
32 sclerosing keratitis 10.2 TEF PRTN3
33 ethmoid sinusitis 10.2 RHNO1 PRTN3
34 anterior scleritis 10.2 TEF PRTN3
35 multiple cranial nerve palsy 10.2 RHNO1 PRTN3
36 down syndrome 10.2
37 double outlet right ventricle 10.2
38 mediastinitis 10.2
39 tracheobronchomalacia 10.2
40 cranial nerve palsy 10.2 RHNO1 PRTN3
41 deep keratitis 10.2 TEF PRTN3
42 camurati-engelmann disease 10.2 LTBP3 FBN1
43 diaphragmatic hernia, congenital 10.2 TEF SLC22A4 FBN1
44 tracheal calcification 10.2 SLC22A4 PRTN3
45 mucopolysaccharidosis, type ii 10.1
46 granulomatosis with polyangiitis 10.1
47 atrial heart septal defect 10.1
48 vasculitis 10.1
49 amyloidosis 10.1
50 chromosomal triplication 10.1

Graphical network of the top 20 diseases related to Tracheal Stenosis:



Diseases related to Tracheal Stenosis

Symptoms & Phenotypes for Tracheal Stenosis

Drugs & Therapeutics for Tracheal Stenosis

Drugs for Tracheal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
5 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
6
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
7 Gastrointestinal Agents Phase 4
8 Methylprednisolone Acetate Phase 4
9 Antiemetics Phase 4
10 Neuroprotective Agents Phase 4
11 Protective Agents Phase 4
12 Antineoplastic Agents, Hormonal Phase 4
13
Azithromycin Approved Phase 1, Phase 2 83905-01-5 55185 447043
14
Budesonide Approved Phase 1, Phase 2 51333-22-3 63006 5281004
15 Anti-Inflammatory Agents Phase 1, Phase 2
16 Hormone Antagonists Phase 1, Phase 2
17 Autonomic Agents Phase 1, Phase 2
18 glucocorticoids Phase 1, Phase 2
19 Hormones Phase 1, Phase 2
20 Anti-Asthmatic Agents Phase 1, Phase 2
21 Respiratory System Agents Phase 1, Phase 2
22 Bronchodilator Agents Phase 1, Phase 2
23
Levobupivacaine Approved, Investigational 27262-47-1 92253
24
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
25
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
26
Dexmedetomidine Approved, Vet_approved 113775-47-6 68602 5311068
27
Atracurium Approved, Experimental, Investigational 64228-79-1 47319
28
Acetylcholine Approved, Investigational Early Phase 1 51-84-3 187
29 Ulipristal acetate 126784-99-4
30 Central Nervous System Depressants
31 Neurotransmitter Agents
32 Adrenergic Agonists
33 Adrenergic alpha-2 Receptor Agonists
34 Analgesics, Non-Narcotic
35 Hypnotics and Sedatives
36 Analgesics
37 Adrenergic Agents
38 abobotulinumtoxinA Early Phase 1
39 Acetylcholine Release Inhibitors Early Phase 1
40 Neuromuscular Agents Early Phase 1
41 Cholinergic Agents Early Phase 1
42 Botulinum Toxins Early Phase 1
43 Botulinum Toxins, Type A Early Phase 1
44 Anti-Bacterial Agents
45 Alkylating Agents
46 Antibiotics, Antitubercular
47 Mitomycins

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients Completed NCT02855502 Phase 4 Prednisolone;Placebo
2 Impedance Cardiography: Clinical Evaluation of Endotracheal Cardiac Output Monitor (ECOM) Completed NCT00924482 Phase 2, Phase 3
3 Replacement of the Airways and/or the Pulmonary Vessels Using a Cryopreserved Arterial Allograft Unknown status NCT01331863 Phase 1, Phase 2
4 Treatment of Laryngotracheal Stenosis Using Autologous Olfactory-mucosa-derived Mesenchymal Stem Cells Completed NCT03130374 Phase 1, Phase 2
5 Incidence of Acute Laryngeal Injury Following Endotracheal Intubation Recruiting NCT03250975 Phase 1, Phase 2 Budesonide and Azithromycin
6 Phase I/IIa Clinical Trial of Stem Cell Based Tissue Engineered Partial Laryngeal Implants in 10 Adult Patients With End-stage Laryngeal Stenosis With 24 Months Follow-up. Withdrawn NCT01977911 Phase 1, Phase 2
7 A Phase I Open-label Study to Assess the Safety, Tolerability and Potential Efficacy of a Novel Tracheal Replacement Consisting of a Tissue-engineered Decellularised Tracheal Scaffold With Seeded Autologous Mesenchymal Cells in Subjects With Severe Tracheal Stenosis or Malacia Suspended NCT02949414 Phase 1
8 A Clinical Trial on Effectiveness and Safety of Inhaling Hydrogen-oxygen to Decreases Inspiratory Effort for the Patients With Tracheal Stenosis: A Randomized, Double-blind and Single-center Clinical Study Unknown status NCT02961387
9 Local Wound Infiltration Versus Bilateral Superficial Cervical Plexus Block With Levobupivacaine for Upper Tracheal Resection and Reconstruction Surgery Under General Anesthesia. Unknown status NCT02949661
10 Maximal Effort-dependent Respiratory Flow Rates: Reproducibility and Reference Values Unknown status NCT03197701
11 Biodegradable Stents in the Management of Stenoses of the Large Airways Unknown status NCT02620319
12 A Comparison of CPAP Delivered by Helmet and O2 Therapy With a Venturi Mask as First Line Intervention in Early ALI/ARDS Unknown status NCT00342368
13 Modified Endotracheal Balloon Dilator to Improve Patient Oxygenation and Allow Ventilation During Airway Procedures Completed NCT02796326
14 Factors to Obstructive Granulation Tissue Formation After Ultraflex Stenting in Benign Tracheal Narrowing Completed NCT01006200
15 Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis Completed NCT00705848
16 Mechanical Ventilation in Patients With \Respiratory Failure: A Comparison of Face Mask and Non Invasive Ventilation Via a Helmet Device Completed NCT01680783
17 F.R.O.N.T. Formula for Pre-operative Airway Assessment and Documentation Completed NCT02313168
18 The Changes of Endotracheal Tube Cuff Pressures After Ear, Head and Neck Surgery-Related Positions: A Prospective Observational Study Completed NCT04037553
19 The Effects of High-flow Nasal Oxygen on Oxygenation During Rigid Bronchoscopy Under General Anesthesia in Pediatric Patients: A Prospective Observational Pilot Study Recruiting NCT03905733
20 Comprehensive Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients Recruiting NCT03455881
21 Treatment Alternatives in Adult Rare Disease; Assessment of Options in Idiopathic Subglottic Stenosis North American Airway Collaborative PR-02 Study (NoAAC PR-02 Study) Active, not recruiting NCT02481817
22 trūFreeze® Spray Cryotherapy Patient Registry Active, not recruiting NCT01802203
23 Airway Stent Modified With 3D Printing for Malignant Stricture Involving Carina and Bronchi Distal to Carina: A Multicenter Study Enrolling by invitation NCT03890575
24 Retrievable Airway Stent Modified With 3D Printing for Benign Disease Involving Carina and Bronchi Distal to Carina: A Multicenter Study Enrolling by invitation NCT03890523
25 Electrical Stimulation of Laryngeal Muscles to Restore Glottal Opening in Patients With Bilateral Vocal Fold Paralysis Enrolling by invitation NCT03085316
26 Levobupivacaine Versus Levobupivacaine - Dexmedetomidine for Ultrasound Guided Bilateral Superficial Cervical Plexus Block for Upper Tracheal Resection and Reconstruction Surgery Under General Anesthesia Not yet recruiting NCT03426527 Levobupivacaine;Levobupivacaine-Dexmedetomidine
27 Modified Endotracheal Balloon Dilator to Improve Oxygenation During Airway Procedures in Children With Tracheal Stenosis Not yet recruiting NCT03411928
28 Comparison of Functional Electrical Stimulation to Repeated Botox Injections for the Treatment of the Bilaterally Paralyzed Human Larynx Not yet recruiting NCT04028674 Early Phase 1 Botulinum toxin type A
29 Reducing Intra-operative Pressure Variations in Paediatric Microcuff Endotracheal Tube Cuffs Not yet recruiting NCT03240354
30 A Review of Tracheal Dimensions in the Pediatric Population Using MRI Terminated NCT00277953
31 A Randomized Study of Mitomycin-C Application in the Endoscopic Surgical Treatment of Patients With Laryngotracheal Stenosis Terminated NCT01523275 Mitomycin -C
32 Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis Refractory to Endoscopic Treatment With Dilatation in Patients With Head and Neck Cancer Terminated NCT03540953 Endoscopic injection of Mitomycin C
33 Office-based Radial Expansion Balloon Dilation of the Esophagus and Trachea Withdrawn NCT00583960
34 Comparing Post-Operative Outcomes Between Gold Laser and Micro-Debriders for Functional Endoscopic Sinus Surgery (FESS) in Patients With Chronic Sinusitis Withdrawn NCT02900794

Search NIH Clinical Center for Tracheal Stenosis

Cochrane evidence based reviews: tracheal stenosis

Genetic Tests for Tracheal Stenosis

Genetic tests related to Tracheal Stenosis:

# Genetic test Affiliating Genes
1 Tracheal Stenosis 29

Anatomical Context for Tracheal Stenosis

MalaCards organs/tissues related to Tracheal Stenosis:

40
Trachea, Thyroid, Heart, Lung, T Cells, Myeloid, Spinal Cord

Publications for Tracheal Stenosis

Articles related to Tracheal Stenosis:

(show top 50) (show all 2770)
# Title Authors PMID Year
1
Slide tracheoplasty: Predictors of outcomes and literature review. 61
31862500 2020
2
Surgical repair of mechanical ventilation induced tracheoesophageal fistula. 61
31705278 2020
3
The role of 3D printing in pediatric airway obstruction: A systematic review. 61
32035351 2020
4
[Surgical treatment of acquired tracheal stenosis in pediatrics]. 61
31984715 2020
5
Preoperative Assessment of Airway Patency During General Anesthesia in a Patient With Severe Tracheal Stenosis: Effectiveness of Noninvasive Positive Pressure Ventilation. 61
31345712 2020
6
Challenging tracheal resection anastomosis: Case series. 61
32035696 2020
7
Delay between onset of indication and definitive surgery for tracheal trauma. 61
31981348 2020
8
Risk factors for decannulation failure after single-stage reconstruction of adult post-intubation tracheal stenosis: 10-year experience at a tertiary center. 61
32003273 2020
9
Coordinated approach to spinal and tracheal reconstruction in a patient with morquio syndrome. 61
31639621 2020
10
[Surgical treatment of extensive posttracheostomy tracheal stenosis using a new technique]. 61
31994504 2020
11
Tracheoplasty for Congenital Tracheal Stenosis with Bilateral Tracheal Bronchus. 61
31996506 2020
12
Clinical and structural aspects of tracheal stenosis and a novel embryological hypothesis of left pulmonary artery sling. 61
31975532 2020
13
Transnasal humidified rapid-insufflation ventilatory exchange can be utilized in tracheal stenosis caused by thyroid tumor. 61
31951920 2020
14
Combined Surgical and Endoscopic Approach for Ring-Sling Complex. 61
30743276 2020
15
Pediatric Tracheal Surgery: A 25-Year Review of Slide Tracheoplasty and Tracheal Resection. 61
31400322 2020
16
Spontaneous breathing anesthesia for cervical tracheal resection and reconstruction. 61
32030251 2019
17
Understanding the impact of slide tracheoplasty in congenital tracheal stenosis. 61
31993362 2019
18
Use of non-invasive ventilation in children with congenital tracheal stenosis. 61
31539787 2019
19
Surgical indication for congenital tracheal stenosis complicated by pulmonary artery sling. 61
32030266 2019
20
Open Airway Surgery in a Paraplegic: The Importance of an Adequate Cough. 61
31364384 2019
21
Impact of fundoplication for gastroesophageal reflux in the outcome of benign tracheal stenosis. 61
31587887 2019
22
Commentary: The role of gastroesophageal reflux in patients with acquired tracheal stenosis. 61
31604634 2019
23
Myhre syndrome: A first familial recurrence and broadening of the phenotypic spectrum. 61
31595668 2019
24
Tracheal Stenosis: Evaluation of an Institutional Protocol and Introduction of Novel Surgical Criteria and Scoring System. 61
31750097 2019
25
Quality of life can be good after slide tracheoplasty for long-segment tracheal stenosis. 61
31435669 2019
26
Transmural rupture and cartilage ring fracture in a tracheobronchial tuberculosis patient. 61
31719984 2019
27
Bioprinted trachea constructs with patient-matched design, mechanical and biological properties. 61
31671417 2019
28
Biodegradable electrospun patch containing cell adhesion or antimicrobial compounds for trachea repair in vivo. 61
31791031 2019
29
Combined Tracheal Resection and Coronary Artery Bypass With ECMO Support. 61
31108047 2019
30
The role of interventional bronchoscopy in the management of post-intubation tracheal stenosis: A 20-year experience. 61
31901372 2019
31
Postoperative respiratory complications and disposition in patients with type 1 laryngeal clefts undergoing injection or repair - A single institution experience. 61
31901483 2019
32
Oxygen reserve index (ORi™) contributes to prediction of hypoxemia and patient safety during tracheal stent insertion using rigid bronchoscopy: a case report. 61
30519896 2019
33
Outcome of congenital tracheal stenosis in children over two decades in a national cardiothoracic surgical unit. 61
31744583 2019
34
Subglottic tracheal stenosis associated with Ehlers-Danlos Syndrome, Hypermobilty Type. 61
31476586 2019
35
Tracheal resection and reconstruction for post-tracheostomy tracheal stenosis treated with T-tube stenting for 10 years. 61
31734860 2019
36
Novel Suture Technique for Slide Tracheoplasty for the Treatment of Long-Segment Tracheal Stenosis. 61
31778789 2019
37
Postintubation Tracheal Stenosis: Management and Results 1993 to 2017. 61
31299233 2019
38
Complete Tracheal Ring Deformity. A Translational Genomics Approach to Pathogenesis. 61
31215789 2019
39
Complications and Outcomes of Acute Respiratory Distress Syndrome. 61
31449145 2019
40
Non-operative management of congenital tracheal stenosis: criteria by computed tomography. 61
31410561 2019
41
Acquired Non-malignant Cervical Trachea-Esophageal Fistula: A Case Series. 61
31741974 2019
42
Asymptomatic congenital tracheal stenosis. 61
31388427 2019
43
[Congenital tracheal stenosis: from clinic to treatment.] 61
31580021 2019
44
Spanish multicentre study on morbidity and pathogenicity of tracheal bronchus in children. 61
31328420 2019
45
Surgical treatment of pulmonary artery sling and tracheal stenosis with or without tracheoplasty: A protocol for a systematic review and meta-analysis. 61
31577770 2019
46
Tracheostomy: Experience at Tertiary Hospital. 61
31742024 2019
47
Tracheal Stenosis Due to IgG4-Related Fibrosing Mediastinitis. 61
30797571 2019
48
Airway Management and Bronchoscopic Treatment of Subglottic and Tracheal Stenosis Using Holmium Laser with Balloon Dilatation. 61
31742002 2019
49
CPAP after endoscopic procedures as add-on therapy for the treatment of tracheal stenosis: a case series. 61
31663300 2019
50
Corrosive injury of the trachea in children. 61
31624626 2019

Variations for Tracheal Stenosis

Expression for Tracheal Stenosis

Search GEO for disease gene expression data for Tracheal Stenosis.

Pathways for Tracheal Stenosis

Pathways related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.72 ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10
2
Show member pathways
11.42 ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10
3
Show member pathways
11.3 TGFB3 LTBP3 FBN1
4
Show member pathways
10.81 ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10

GO Terms for Tracheal Stenosis

Cellular components related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 TGFB3 PRTN3 LTBP3 GALNS FBN1 ADAMTSL4
2 microfibril GO:0001527 9.16 FBN1 ADAMTS10
3 collagen-containing extracellular matrix GO:0062023 9.1 TGFB3 PRTN3 LTBP3 FBN1 ADAMTSL4 ADAMTS10

Biological processes related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.02 PRTN3 ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10

Molecular functions related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.02 PRTN3 ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10
2 transforming growth factor beta binding GO:0050431 8.96 TGFB3 LTBP3

Sources for Tracheal Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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