TBM
MCID: TRC037
MIFTS: 23

Tracheobronchomalacia (TBM)

Categories: Rare diseases

Aliases & Classifications for Tracheobronchomalacia

MalaCards integrated aliases for Tracheobronchomalacia:

Name: Tracheobronchomalacia 52 71
Tbm 52

Classifications:



External Ids:

UMLS 71 C0340231

Summaries for Tracheobronchomalacia

NIH Rare Diseases : 52 Tracheobronchomalacia (TBM) is a rare condition that occurs when the walls of the airway (specifically the trachea and bronchi ) are weak. This can cause the airway to become narrow or collapse. There are two forms of TBM. One typically develops during infancy or early childhood (primary TBM). The other is an acquired form usually seen in adults (acquired or secondary TBM). Some people with TBM may initially have no signs or symptoms. However, the condition typically is progressive (worsening over time) and most people will eventually develop shortness of breath, cough, sputum retention (inability to clear mucus from the respiratory tract), and/or wheezing or stridor with breathing. Most cases of primary TBM are caused by genetic conditions that weaken the walls of the airway, while the acquired form may occur due to trauma, chronic inflammation, and/or prolonged compression of the airways. The acquired form is often seen in adults with common respiratory conditions such as asthma, chronic bronchitis, and emphysema. In many cases, the cause is not known. Treatment may only be needed if signs and symptoms are present, of there is complete or near-complete collapse of the airway. Depending on severity, treatment options may include continuous positive airway pressure (CPAP) , stenting , surgical correction (tracheobronchoplasty), and tracheostomy .

MalaCards based summary : Tracheobronchomalacia, also known as tbm, is related to bronchomalacia and tuberculous meningitis. The drugs Acetylcysteine and Guaifenesin have been mentioned in the context of this disorder. Affiliated tissues include trachea, lung and heart.

Wikipedia : 74 Tracheobronchomalacia or TBM is a condition characterized by flaccidity of the tracheal support... more...

Related Diseases for Tracheobronchomalacia

Diseases related to Tracheobronchomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 bronchomalacia 12.2
2 tuberculous meningitis 11.6
3 atelosteogenesis, type i 11.2
4 tracheomalacia 10.7
5 meningitis 10.5
6 respiratory failure 10.4
7 lung disease 10.4
8 interstitial nephritis 10.4
9 pulmonary disease, chronic obstructive 10.3
10 esophageal atresia 10.3
11 bronchopulmonary dysplasia 10.3
12 gastroesophageal reflux 10.3
13 bronchitis 10.3
14 syncope 10.3
15 hydrocephalus 10.2
16 tracheoesophageal fistula with or without esophageal atresia 10.2
17 ventricular septal defect 10.2
18 relapsing polychondritis 10.2
19 bronchiolitis 10.2
20 tracheal stenosis 10.2
21 pulmonary embolism 10.2
22 47,xyy 10.2
23 mounier-kuhn syndrome 10.2
24 alzheimer disease 10.1
25 systemic lupus erythematosus 10.1
26 otitis media 10.1
27 mycobacterium tuberculosis 1 10.1
28 membranous nephropathy 10.1
29 cysticercosis 10.1
30 viral meningitis 10.1
31 chronic meningitis 10.1
32 fanconi syndrome 10.1
33 nephrotic syndrome 10.1
34 guillain-barre syndrome 10.1
35 glomerulonephritis 10.1
36 skin carcinoma 10.1
37 bacterial meningitis 10.1
38 brain injury 10.1
39 autoimmune disease 10.1
40 campomelic dysplasia 10.1
41 laryngomalacia 10.1
42 tracheobronchomegaly 10.1
43 sleep apnea 10.1
44 scoliosis 10.1
45 heart septal defect 10.1
46 bronchiolitis obliterans 10.1
47 amyloidosis 10.1
48 pulmonary emphysema 10.1
49 chromosomal triplication 10.1
50 laryngeal cleft 10.1

Graphical network of the top 20 diseases related to Tracheobronchomalacia:



Diseases related to Tracheobronchomalacia

Symptoms & Phenotypes for Tracheobronchomalacia

Drugs & Therapeutics for Tracheobronchomalacia

Drugs for Tracheobronchomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational 616-91-1 12035
2
Guaifenesin Approved, Investigational, Vet_approved 93-14-1 3516
3
Codeine Approved, Illicit 76-57-3 5284371
4
Cocaine Approved, Illicit 50-36-2 5760 446220
5 N-monoacetylcystine
6 Anesthetics
7 Chlorpheniramine, phenylpropanolamine drug combination
8 Expectorants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Efficacy and Safety of the HCPA-1 Silicone Stent in the Treatment of Central Airway Obstructions Unknown status NCT01389531
2 Tracheobronchomalacia: Treatment Outcomes Completed NCT00550602
3 Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis Completed NCT00705848
4 Pressure Dependent Tracheal Obstruction in Copd Patients Completed NCT01679808
5 Tracheal Mechanics During Bronchoscopy Completed NCT00536315
6 Correlation Between Trachebroncho Malacia/Hyperdynamic Airway Collapse And Obstructive Sleep Apnea Completed NCT02097212
7 Symptomatic Treatment of Excessive Dynamic Airway Collapse Using Daytime Portable Continuous Positive Airway Pressure Completed NCT02763631
8 Airway Stents for Excessive Dynamic Airway Collapse: A Randomized Controlled Trial Enrolling by invitation NCT02982876
9 PEEP Mask for TBM-Induced Cough Not yet recruiting NCT04169282

Search NIH Clinical Center for Tracheobronchomalacia

Genetic Tests for Tracheobronchomalacia

Anatomical Context for Tracheobronchomalacia

MalaCards organs/tissues related to Tracheobronchomalacia:

40
Trachea, Lung, Heart, Thyroid, Testes, Thymus, Liver

Publications for Tracheobronchomalacia

Articles related to Tracheobronchomalacia:

(show top 50) (show all 401)
# Title Authors PMID Year
1
Tracheomalacia/Tracheobronchomalacia and hyperdynamic airway collapse. 61 52
23337062 2013
2
Innovative management of severe tracheobronchomalacia using anterior and posterior tracheobronchopexy. 61
30908672 2020
3
Thoracoscopic aortopexy for symptomatic tracheobronchomalacia. 61
31826817 2020
4
Dynamic Tracheobronchial Compression in Steep Trendelenburg Position With Pneumoperitoneum for Robotic-Assisted Cystectomy: A Case Report. 61
31789827 2020
5
Tracheal opening manoeuvre (PEEP-20) in a patient with bronchopulmonary dysplasia and severe tracheobronchomalacia with neurally adjusted ventilatory assist (NAVA). 61
31969395 2020
6
Relapsing polychondritis with large airway involvement. 61
31741739 2020
7
Association between Inhaled Corticosteroids and Tracheobronchomalacia. 61
31978429 2020
8
Bronchoscopy for Chronic Unexplained Cough: Use of Biopsies and Cultures Increase Diagnostic Yield. 61
31651543 2020
9
Clinical features and outcome in 25 dogs with respiratory-associated pulmonary hypertension treated with sildenafil. 61
31816127 2020
10
Pediatric Airway Stent Designed to Facilitate Mucus Transport and Atraumatic Removal. 61
30990171 2020
11
Three-dimensional printed trachea helps to design tailored treatment for tracheobronchomalacia. 61
31834287 2019
12
In vitro degradation and biocompatibility evaluation of typical biodegradable metals (Mg/Zn/Fe) for the application of tracheobronchial stenosis. 61
31667439 2019
13
Subglottic stenosis and endobronchial disease in granulomatosis with polyangiitis. 61
31199488 2019
14
The use of expandable metallic airway stent in a baby with tracheomalacia: A case report. 61
31607740 2019
15
Pediatric tracheocutaneous fistula closure following tracheostomy decannulation. 61
31299421 2019
16
Airway spasm or collapse? An alternate mechanism of action for an important side effect of Sildenafil warrants consideration in patients with tracheobronchomalacia. 61
31279571 2019
17
Expiratory Central Airway Collapse in Adults: Anesthetic Implications (Part 1). 61
30279064 2019
18
ERS statement on tracheomalacia and bronchomalacia in children. 61
31320455 2019
19
3D-printed, externally-implanted, bioresorbable airway splints for severe tracheobronchomalacia. 61
30794335 2019
20
Great vessel anomalies and their impact on the surgical treatment of tracheobronchomalacia. 61
31422856 2019
21
Single-Lumen Endotracheal Tube and Bronchial Blocker for Airway Management During Tracheobronchoplasty for Tracheobronchomalacia: A Case Report. 61
31385817 2019
22
Longitudinal Follow-up of Patients With Tracheobronchomalacia After Undergoing Tracheobronchoplasty: Computed Tomography Findings and Clinical Correlation. 61
29957676 2019
23
Biodegradable airway stents: Novel treatment of airway obstruction in children. 61
31199878 2019
24
Flexible Fiberoptic Bronchoscopy Directed Interventions in Neonatal Intensive Care Unit. 61
31333210 2019
25
An Adult Case of Pulmonary Artery Sling Accompanied by Tracheobronchomalacia. 61
30713315 2019
26
Surgical Approach for Hypoplastic Mirror Circumflex Aortic Arch. 61
30359593 2019
27
Technique, pitfalls, quality, radiation dose and findings of dynamic 4-dimensional computed tomography for airway imaging in infants and children. 61
30683962 2019
28
Diagnosis, Classification, and Management of Pediatric Tracheobronchomalacia: A Review. 61
30589929 2019
29
Bronchoscopy in neonates with severe bronchopulmonary dysplasia in the NICU. 61
30518799 2019
30
Excessive Dynamic Airway Collapse or Tracheobronchomalacia: Does It Matter? 61
30054115 2019
31
First series of minimally invasive, robot-assisted tracheobronchoplasty with mesh for severe tracheobronchomalacia. 61
30669239 2019
32
Circulatory Collapse due to Hyperinflation in a Patient with Tracheobronchomalacia: A Case Report and Brief Review. 61
30838137 2019
33
Four-Dimensional Thoracic CT in Free-Breathing Children. 61
30627021 2019
34
The utility of 3D-printed airway stents to improve treatment strategies for central airway obstructions. 61
30207189 2019
35
Tracheobronchomalacia: Does One Size Fit All? 61
31077809 2019
36
Tracheomalacia and Tracheobronchomalacia in Pediatrics: An Overview of Evaluation, Medical Management, and Surgical Treatment. 61
31921725 2019
37
A case of tracheobronchomalacia due to relapsing polychondritis treated with Montgomery T-tube. 61
30886718 2019
38
Descending Aortopexy and Posterior Tracheopexy for Severe Tracheomalacia and Left Mainstem Bronchomalacia. 61
29524603 2019
39
Tracheobronchomalacia and Excessive Dynamic Airway Collapse: Medical and Surgical Treatment. 61
30641584 2018
40
Benign Central Airway Obstruction. 61
30641591 2018
41
Patient-specific, 3-dimensionally engineered silicone Y-stents in tracheobronchomalacia: Clinical experience with a novel type of airway stent. 61
30104064 2018
42
An atypical phenotype of a patient with infantile spinal muscular atrophy with respiratory distress type 1 (SMARD 1). 61
29653221 2018
43
Aortopexy for the treatment of tracheobronchomalacia in 100 children: a 10-year single-centre experience. 61
29514258 2018
44
Computed tomographic and radiographic bronchial collapse may be a normal characteristic of forced expiration in dogs. 61
29786925 2018
45
Single-Center Experience of Tracheobronchoplasty for Tracheobronchomalacia: Perioperative Outcomes. 61
29684374 2018
46
New insights in the diagnosis of chronic refractory cough. 61
30053955 2018
47
Difficulty in tracheal extubation followed by tracheal collapse after balloon dilatation for tracheal stenosis therapy: A case report. 61
29851818 2018
48
A novel association of campomelic dysplasia and hydrocephalus with an unbalanced chromosomal translocation upstream of SOX9. 61
29695406 2018
49
Flexible bronchoscopy in pulmonary diseases in children with congenital cardiovascular abnormalities. 61
29904428 2018
50
Tracheobronchial stenting for airway malacia. 61
29174374 2018

Variations for Tracheobronchomalacia

Expression for Tracheobronchomalacia

Search GEO for disease gene expression data for Tracheobronchomalacia.

Pathways for Tracheobronchomalacia

GO Terms for Tracheobronchomalacia

Sources for Tracheobronchomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....