MCID: TRC037
MIFTS: 25

Tracheobronchomalacia

Categories: Rare diseases

Aliases & Classifications for Tracheobronchomalacia

MalaCards integrated aliases for Tracheobronchomalacia:

Name: Tracheobronchomalacia 54 74
Tbm 54

Classifications:



External Ids:

UMLS 74 C0340231

Summaries for Tracheobronchomalacia

NIH Rare Diseases : 54 Tracheobronchomalacia (TBM) is a rare condition that occurs when the walls of the airway (specifically the trachea and bronchi) are weak. This can cause the airway to become narrow or collapse. There are two forms of TBM. One typically develops during infancy or early childhood (primary TBM). The other is an acquired form usually seen in adults (acquired or secondary TBM). Some people with TBM may initially have no signs or symptoms. However, the condition typically is progressive (worsening over time) and most people will eventually develop shortness of breath, cough, sputum retention (inability to clear mucus from the respiratory tract), and/or wheezing or stridor with breathing. Most cases of primary TBM are caused by genetic conditions that weaken the walls of the airway, while the acquired form may occur due to trauma, chronic inflammation, and/or prolonged compression of the airways. The acquired form is often seen in adults with common respiratory conditions such as asthma, chronic bronchitis, and emphysema. In many cases, the cause is not known. Treatment may only be needed if signs and symptoms are present, of there is complete or near-complete collapse of the airway. Depending on severity, treatment options may include continuous positive airway pressure (CPAP), stenting, surgical correction (tracheobronchoplasty), and tracheostomy.

MalaCards based summary : Tracheobronchomalacia, also known as tbm, is related to bronchomalacia and tuberculous meningitis. The drugs Cocaine and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include trachea, brain and testes.

Wikipedia : 77 Tracheobronchomalacia or TBM is a condition characterized by flaccidity of the tracheal support... more...

Related Diseases for Tracheobronchomalacia

Graphical network of the top 20 diseases related to Tracheobronchomalacia:



Diseases related to Tracheobronchomalacia

Symptoms & Phenotypes for Tracheobronchomalacia

Drugs & Therapeutics for Tracheobronchomalacia

Drugs for Tracheobronchomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cocaine Approved, Illicit Not Applicable 50-36-2 446220 5760
2
Acetylcysteine Approved, Investigational Not Applicable 616-91-1 12035
3
Guaifenesin Approved, Investigational, Vet_approved Not Applicable 93-14-1 3516
4
Codeine Approved, Illicit Not Applicable 76-57-3 5284371
5 Anesthetics Not Applicable
6 N-monoacetylcystine Not Applicable
7 Chlorpheniramine, phenylpropanolamine drug combination Not Applicable
8 Expectorants Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study to Assess the Safety, Tolerability and Potential Efficacy of a Tracheal Replacement Consisting of a Tissue-engineered Tracheal Scaffold With Seeded Mesenchymal Cells Suspended NCT02949414 Phase 1
2 Efficacy and Safety Evaluation of HCPA-1 Silicone Stent in the Treatment of Central Airway Obstructions Unknown status NCT01389531 Not Applicable
3 Tracheobronchomalacia: Treatment Outcomes Completed NCT00550602
4 Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis Completed NCT00705848
5 Pressure Dependent Tracheal Obstruction in Copd Patients Completed NCT01679808
6 Symptomatic Treatment of Excessive Dynamic Airway Collapse Using Daytime Portable Continuous Positive Airway Pressure Completed NCT02763631 Not Applicable
7 Tracheal Mechanics During Bronchoscopy Completed NCT00536315
8 Correlation Between Trachebroncho Malacia/Hyperdynamic Airway Collapse And Obstructive Sleep Apnea Completed NCT02097212
9 Mapping Sound Propagation Through the Human Lung for Better Diagnosis Recruiting NCT03043898
10 Airway Stents for Excessive Dynamic Airway Collapse Enrolling by invitation NCT02982876 Not Applicable

Search NIH Clinical Center for Tracheobronchomalacia

Genetic Tests for Tracheobronchomalacia

Anatomical Context for Tracheobronchomalacia

MalaCards organs/tissues related to Tracheobronchomalacia:

42
Trachea, Brain, Testes, Lymph Node, Spinal Cord, Kidney, T Cells

Publications for Tracheobronchomalacia

Articles related to Tracheobronchomalacia:

(show top 50) (show all 208)
# Title Authors Year
1
Prevailing practices in the treatment of tuberculous meningitis (TBM): a cross-sectional study. ( 31085623 )
2019
2
A case of tracheobronchomalacia due to relapsing polychondritis treated with Montgomery T-tube. ( 30886718 )
2019
3
Excessive Dynamic Airway Collapse or Tracheobronchomalacia: Does It Matter? ( 30054115 )
2019
4
First series of minimally invasive, robot-assisted tracheobronchoplasty with mesh for severe tracheobronchomalacia. ( 30669239 )
2019
5
An Adult Case of Pulmonary Artery Sling Accompanied by Tracheobronchomalacia. ( 30713315 )
2019
6
3D-printed, externally-implanted, bioresorbable airway splints for severe tracheobronchomalacia. ( 30794335 )
2019
7
Circulatory Collapse due to Hyperinflation in a Patient with Tracheobronchomalacia: A Case Report and Brief Review. ( 30838137 )
2019
8
Innovative management of severe tracheobronchomalacia using anterior and posterior tracheobronchopexy. ( 30908672 )
2019
9
Tracheobronchomalacia: Does one size fit all? ( 31077809 )
2019
10
Detection and Distinction of Mild Brain Injury Effects in a Ferret Model Using Diffusion Tensor MRI (DTI) and DTI-Driven Tensor-Based Morphometry (D-TBM). ( 30174584 )
2018
11
Utility of pyrosequencing for rapid detection of tubercular meningitis (TBM) and associated susceptibility directly from CSF specimens. ( 30029915 )
2018
12
Single-Center Experience of Tracheobronchoplasty for Tracheobronchomalacia: Perioperative Outcomes. ( 29684374 )
2018
13
Longitudinal Follow-up of Patients With Tracheobronchomalacia After Undergoing Tracheobronchoplasty: Computed Tomography Findings and Clinical Correlation. ( 29957676 )
2018
14
Patient-specific, 3-dimensionally engineered silicone Y-stents in tracheobronchomalacia: Clinical experience with a novel type of airway stent. ( 30104064 )
2018
15
Diagnosis, Classification, and Management of Pediatric Tracheobronchomalacia: A Review. ( 30589929 )
2018
16
Tracheobronchomalacia and Excessive Dynamic Airway Collapse: Medical and Surgical Treatment. ( 30641584 )
2018
17
Tracheobronchomalacia and Excessive Dynamic Airway Collapse. ( 29433717 )
2018
18
A novel endobronchial approach to massive hemoptysis complicating silicone Y-stent placement for tracheobronchomalacia: A case report. ( 29465600 )
2018
19
Post-intubation tracheobronchomalacia in a young adult: A rare case report. ( 29487785 )
2018
20
Aortopexy for the treatment of tracheobronchomalacia in 100 children: a 10-year single-centre experience. ( 29514258 )
2018
21
Tracheobronchomalacia and Expiratory Collapse of Central Airways. ( 29627050 )
2018
22
Suboptimal Exposure to Anti-TB Drugs in a TBM/HIV+ Population Is Not Related to Antiretroviral Therapy. ( 28160272 )
2018
23
Tracheobronchomalacia Is Associated with Increased Morbidity in Bronchopulmonary Dysplasia. ( 28622012 )
2017
24
Tracheobronchomalacia in Neonates: The "New Bronchopulmonary Dysplasia" Is Not Just about the Alveoli. ( 28862496 )
2017
25
A Case of Tracheobronchomalacia Mimicking Acute Pulmonary Embolism. ( 28924136 )
2017
26
Sudden Respiratory Failure due to Tracheobronchomalacia by Relapsing Polychondritis, Successfully Rescued by Multiple Metallic Stenting and Tracheostomy. ( 29021454 )
2017
27
A comparison of virtual bronchoscopy versus flexible bronchoscopy in the diagnosis of tracheobronchomalacia in children. ( 27641078 )
2017
28
Laser tracheobronchoplasty: a novel technique for the treatment of symptomatic tracheobronchomalacia. ( 27766409 )
2017
29
Tracheobronchomalacia as a Rare Cause of Chronic Dyspnea in Adults. ( 28068652 )
2017
30
Current concepts in severe adult tracheobronchomalacia: evaluation and treatment. ( 28203438 )
2017
31
Tracheobronchomalacia. ( 28549723 )
2017
32
Tracheobronchomalacia. ( 28551016 )
2017
33
Cine MRI of Tracheal Dynamics in Healthy Volunteers and Patients With Tracheobronchomalacia. ( 28796542 )
2017
34
Recurrent dyspnea and wheezing- pulmonary function test and dynamic computed tomography may unfold the diagnosis of tracheobronchomalacia. ( 29147472 )
2017
35
Direct tracheobronchopexy via left lateral thoracotomy for severe tracheobronchomalacia. ( 29224761 )
2017
36
Central Airway Obstruction: Benign Strictures, Tracheobronchomalacia, and Malignancy-related Obstruction. ( 26874192 )
2016
37
Treatment of severe tracheobronchomalacia: Ten-year experience. ( 26968054 )
2016
38
Trial of Portable Continuous Positive Airway Pressure for the Management of Tracheobronchomalacia. ( 26982389 )
2016
39
Awareness, Competencies, and Practice Patterns in Tracheobronchomalacia: A Survey of Pulmonologists. ( 27058715 )
2016
40
Surgical Treatment of Tracheobronchomalacia: A novel approach. ( 27237407 )
2016
41
Is silicone stent insertion a clinically useful option for tracheobronchomalacia? ( 27511508 )
2016
42
Tracheobronchomalacia diagnosed by tracheobronchography in ventilator-dependent infants. ( 27541367 )
2016
43
Tracheobronchomalacia/excessive dynamic airway collapse in patients with chronic obstructive pulmonary disease with persistent expiratory wheeze: A pilot study. ( 27578929 )
2016
44
Tracheobronchomalacia in obstructive airway diseases. ( 27578945 )
2016
45
New developments towards the management of severe cases of tracheobronchomalacia. ( 28149538 )
2016
46
Personalized interventions for tracheobronchomalacia. ( 28149539 )
2016
47
Tracheobronchomalacia treatment: how far have we come? ( 28149540 )
2016
48
Diagnostic accuracy of a uniform research case definition for TBM in children: a prospective study. ( 27287642 )
2016
49
Brain structural changes following adaptive cognitive training assessed by Tensor-Based Morphometry (TBM). ( 27477628 )
2016
50
Correlation of clinical, laboratory and drug susceptibility profiles in 176 patients with culture positive TBM in a tertiary neurocare centre. ( 27717649 )
2016

Variations for Tracheobronchomalacia

Expression for Tracheobronchomalacia

Search GEO for disease gene expression data for Tracheobronchomalacia.

Pathways for Tracheobronchomalacia

GO Terms for Tracheobronchomalacia

Sources for Tracheobronchomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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