TEF
MCID: TRC040
MIFTS: 48

Tracheoesophageal Fistula (TEF)

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Tracheoesophageal Fistula

MalaCards integrated aliases for Tracheoesophageal Fistula:

Name: Tracheoesophageal Fistula 53 29 55 6
Tracheoesophageal Fistula with or Without Esophageal Atresia 53
Te Fistula 53
Tef 53

Classifications:



Summaries for Tracheoesophageal Fistula

NIH Rare Diseases : 53 Tracheoesophageal fistula (TEF) is a life-threatening condition in which there is an abnormal connection between the esophagus and trachea (windpipe). The esophagus and trachea run next to each other through the chest cavity. The esophagus carries food and saliva to the stomach, while the trachea carries air to the lungs. TEF can lead to severe and fatal lung complications. Saliva and gastric secretions can be aspirated into the lungs, and normal swallowing and digestion of food cannot occur. Most affected people are diagnosed immediately after birth or during infancy. Symptoms may include frothy bubbles of mucus in the mouth and nose; episodes of coughing and choking; and worsening symptoms during feeding. TEF may be isolated, or it may occur with other physical or developmental abnormalities (most commonly, esophageal atresia). In many cases the cause is unknown but it has been associated with some chromosome disorders. In some cases it may be acquired later in life after a cancer, infection, ruptured diverticula, or trauma. Treatment includes immediate surgical repair with survival rates of almost 100%.

MalaCards based summary : Tracheoesophageal Fistula, also known as tracheoesophageal fistula with or without esophageal atresia, is related to tracheoesophageal fistula with or without esophageal atresia and isolated tracheoesophageal fistula. An important gene associated with Tracheoesophageal Fistula is BRCA2 (BRCA2, DNA Repair Associated), and among its related pathways/superpathways are Ectoderm Differentiation and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drug threonine has been mentioned in the context of this disorder. Affiliated tissues include trachea, lung and heart, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Wikipedia : 76 A tracheoesophageal fistula (TEF, or TOF; see spelling differences) is an abnormal connection (fistula)... more...

Related Diseases for Tracheoesophageal Fistula

Diseases related to Tracheoesophageal Fistula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 tracheoesophageal fistula with or without esophageal atresia 34.1 BRCA2 FANCC PALB2
2 isolated tracheoesophageal fistula 34.0 BRCA2 FANCC PALB2
3 vater/vacterl association 33.0 HOXD13 ZIC3
4 esophageal atresia 30.7 CHD7 GLI3 LPP MYCN NOG SHH
5 vacterl association 30.0 HOXD13 LPP SHH ZIC3
6 esophageal atresia/tracheoesophageal fistula 12.8
7 tracheoesophageal fistula symphalangism 12.3
8 martinez-frias syndrome 12.0
9 feingold syndrome 1 11.6
10 vacterl association with hydrocephalus 11.4
11 vacterl association, x-linked, with or without hydrocephalus 11.4
12 feingold syndrome 2 11.3
13 fanconi anemia, complementation group b 11.3
14 mitchell-riley syndrome 11.3
15 plasminogen deficiency, type i 11.1
16 gastrointestinal defects and immunodeficiency syndrome 11.1
17 orofaciodigital syndrome viii 11.1
18 tracheal disease 11.1
19 fusariosis 11.1
20 ametropic amblyopia 11.1
21 diaphragmatic eventration 11.1
22 diaphragm disease 11.1
23 intestinal atresia 11.1
24 rectal disease 11.1
25 eumycotic mycetoma 11.1
26 trachea leiomyoma 11.1
27 anus disease 11.1
28 esophageal disease 11.1
29 mediastinitis 11.1
30 dyskinesia of esophagus 11.1
31 lung agenesis 10.4
32 lymphoma 10.4
33 tracheomalacia 10.4
34 gastroesophageal reflux 10.3
35 diaphragmatic hernia, congenital 10.3
36 duodenal atresia 10.3
37 tracheal stenosis 10.3
38 esophageal cancer 10.3
39 pancreatic neuroendocrine tumor 10.3 BRCA2 PALB2
40 lung cancer 10.2
41 hypertrophic pyloric stenosis 10.2
42 pyloric stenosis 10.2
43 tracheal agenesis 10.2
44 pancreatic cancer 3 10.2 DCTN5 PALB2
45 pneumonia 10.2
46 right aortic arch 10.2
47 hereditary breast ovarian cancer syndrome 10.2 BRCA2 BRIP1 PALB2
48 pancreas adenocarcinoma 10.2 BRCA2 PALB2 SHH
49 cerebellum cancer 10.1 SHH SYP
50 holoprosencephaly 4 10.1 GLI3 SHH

Graphical network of the top 20 diseases related to Tracheoesophageal Fistula:



Diseases related to Tracheoesophageal Fistula

Symptoms & Phenotypes for Tracheoesophageal Fistula

GenomeRNAi Phenotypes related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.1 BRCA2 BRIP1 FANCA FANCC PALB2 ZIC3

MGI Mouse Phenotypes related to Tracheoesophageal Fistula:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.4 BRCA2 BRIP1 CHD7 FANCA FANCC GLI3
2 growth/size/body region MP:0005378 10.31 BRCA2 CHD7 DCTN5 FANCA GLI3 HOXD13
3 behavior/neurological MP:0005386 10.3 BRCA2 CHD7 DCTN5 MYCN PALB2 S100B
4 embryo MP:0005380 10.3 BRCA2 CHD7 FANCA GLI3 HOXD13 MYCN
5 endocrine/exocrine gland MP:0005379 10.25 BRCA2 BRIP1 CHD7 FANCA FANCC GLI3
6 homeostasis/metabolism MP:0005376 10.25 BRCA2 BRIP1 CHD7 FANCA GLI3 LPP
7 cardiovascular system MP:0005385 10.24 CHD7 DCTN5 FANCA GLI3 MYCN NOG
8 craniofacial MP:0005382 10.23 CHD7 DCTN5 FANCA GLI3 MYCN NOG
9 mortality/aging MP:0010768 10.23 BRCA2 CHD7 FANCA GLI3 HOXD13 LPP
10 digestive/alimentary MP:0005381 10.22 BRCA2 CHD7 GLI3 HOXD13 MYCN NOG
11 nervous system MP:0003631 10.18 BRCA2 BRIP1 CHD7 DCTN5 GLI3 MYCN
12 limbs/digits/tail MP:0005371 10.13 BRCA2 CHD7 GLI3 HOXD13 MYCN NOG
13 reproductive system MP:0005389 10.13 BRCA2 BRIP1 CHD7 FANCA FANCC GLI3
14 integument MP:0010771 10.1 BRCA2 GLI3 HOXD13 NOG PALB2 S100B
15 normal MP:0002873 10.07 BRCA2 C9orf3 GLI3 MYCN NOG S100B
16 hearing/vestibular/ear MP:0005377 10 CHD7 GLI3 NOG SHH SOX2 ZIC3
17 skeleton MP:0005390 9.93 BRCA2 CHD7 DCTN5 FANCA FANCC GLI3
18 neoplasm MP:0002006 9.91 BRCA2 BRIP1 FANCA PALB2 SHH SOX2
19 respiratory system MP:0005388 9.8 CHD7 GLI3 MYCN NOG SHH SOX2
20 vision/eye MP:0005391 9.32 CHD7 DCTN5 FANCA GLI3 HOXD13 MYCN
21 taste/olfaction MP:0005394 9.26 GLI3 NOG SHH SOX2

Drugs & Therapeutics for Tracheoesophageal Fistula

Drugs for Tracheoesophageal Fistula (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 threonine Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Transanastomotic Tube for Proximal Esophageal Atresia With Distal Tracheoesophageal Fistula Repair Recruiting NCT03730454 Phase 4
2 Endoscopic Closure of Tracheoesophageal Fistulas With Occluder Device Terminated NCT01153061 Phase 4
3 Adipose Derived SVF for Aero-digestive Fistulae Not yet recruiting NCT03792360 Phase 1 SVF (Stromal Vascular Fraction)
4 Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood Gases Unknown status NCT01467245 Not Applicable
5 Trichloroacetic Acid for Endoscopic Tracho-esophageal Fistula Repair Unknown status NCT01287312 Not Applicable
6 Chewing in Children With Repaired Esophageal Atresia-tracheoesophageal Fistula Completed NCT03026491
7 Prospective Data Collection of Patients < 6 Months of Age Undergoing Thoracoscopic Surgery Completed NCT02033772
8 High-resolution Esophageal Manometry Completed NCT03415893
9 Ultrasound Guided Percutaneous Tracheostomy Compared to Bronchoscopy Guided Percutaneous Tracheostomy Completed NCT02084862 Not Applicable
10 National Register of Oesophageal Atresia Recruiting NCT02883725
11 Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients Recruiting NCT03455881
12 Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries Recruiting NCT03666767
13 A Physiological Study to Determine the Enteral Threonine Requirements in Infants Aged 1 to 6 Months Enrolling by invitation NCT02364843 Not Applicable

Search NIH Clinical Center for Tracheoesophageal Fistula

Genetic Tests for Tracheoesophageal Fistula

Genetic tests related to Tracheoesophageal Fistula:

# Genetic test Affiliating Genes
1 Tracheoesophageal Fistula 29

Anatomical Context for Tracheoesophageal Fistula

MalaCards organs/tissues related to Tracheoesophageal Fistula:

41
Trachea, Lung, Heart, Bone, Kidney, B Cells, Pancreas

Publications for Tracheoesophageal Fistula

Articles related to Tracheoesophageal Fistula:

(show top 50) (show all 1011)
# Title Authors Year
1
Structural airway abnormalities contribute to dysphagia in children with esophageal atresia and tracheoesophageal fistula. ( 29429770 )
2018
2
Experience of diagnosis and treatment of 31 H-type tracheoesophageal fistula in a single clinical center. ( 29855692 )
2018
3
Pneumomediastinum following iatrogenic pharyngeal perforation during tracheoesophageal fistula repair. ( 29628860 )
2018
4
Repair of congenital esophageal atresia with tracheoesophageal fistula repair in Ontario over the last 20years: Volume and outcomes. ( 29519572 )
2018
5
A new method of tracheoesophageal fistula treatment: Using an atrial septal defect occluder device for closure-The first Turkish experience. ( 29730753 )
2018
6
Pneumothorax in a preterm during tracheoesophageal fistula repair: Challenges in diagnosis and management. ( 29416484 )
2018
7
Endoscopic closure of tracheoesophageal fistula for tuberculosis with an over-the-scope-clip. ( 29931992 )
2018
8
Tracheoesophageal fistula diagnosis during open tracheostomy. ( 29487265 )
2018
9
Pre- and post-operative visualization of neonatal esophageal atresia/tracheoesophageal fistula via magnetic resonance imaging. ( 29399473 )
2018
10
Endoscopic management of recurrent tracheoesophageal fistula induced by chronic use of nonsteroidal anti-inflammatory drugs: a case report and review of the literature. ( 29742066 )
2018
11
A hybrid endoscopic technique to close tracheoesophageal fistula. ( 29905178 )
2018
12
Basic Knowledge of Tracheoesophageal Fistula and Esophageal Atresia. ( 29373345 )
2018
13
Characteristics and outcomes of children with ductal-dependent congenital heart disease and esophageal atresia/tracheoesophageal fistula: A multi-institutional analysis. ( 29325785 )
2018
14
Neurodevelopmental outcomes of infants with esophageal atresia and tracheoesophageal fistula. ( 29429769 )
2018
15
Successful endoscopic closure of tracheoesophageal fistula using a Padlock ClipTM. ( 29442487 )
2018
16
Bevacizumab-induced tracheoesophageal fistula in a patient suffering from lung cancer with bulky subcarinal lymph node: a case report. ( 29581622 )
2018
17
Postoperative pain management for tracheoesophageal fistula repair using transverse, in-plane, ultrasound guided paravertebral technique in a 2a8^kg neonate. ( 29980000 )
2018
18
Oral feeding outcomes in infants with esophageal atresia and tracheoesophageal fistula. ( 29519575 )
2018
19
A Hem-o-Lok-Induced Tracheoesophageal Fistula Cured By Temporary Airway Stenting Modified With Three-Dimensional Printing. ( 29763597 )
2018
20
Trans-Tracheal Cyanoacrylate Glue Injection for the Management of Malignant Tracheoesophageal Fistula. ( 29941936 )
2018
21
Successful repair using thymus pedicle flap for tracheoesophageal fistula: a case report. ( 29796790 )
2018
22
Pharyngocutaneous and tracheoesophageal fistula closure using supraclavicular artery island flap. ( 29602967 )
2018
23
Successful treatment of tracheoesophageal fistula using a covered esophageal stent. ( 29761794 )
2018
24
Intentional tracheoesophageal fistula cannulation for gastric decompression in type C esophageal atresia. ( 29484765 )
2018
25
Surgical management of tracheoesophageal fistula. ( 29707512 )
2018
26
Esophageal Atresia with Tracheoesophageal Fistula and Gastroesophageal Reflux in Children: Dental Considerations and Case Report. ( 29750630 )
2018
27
The utility of the oxygen reserve indexa8c in a neonate undergoing re-exploration of a tracheoesophageal fistula. ( 29643560 )
2018
28
Vocal cord dysfunction following esophageal atresia and tracheoesophageal fistula (EA/TEF) repair. ( 30274710 )
2018
29
Prevalence and natural history of scoliosis and associated congenital vertebral anomalies in patients operated for esophageal atresia with or without tracheoesophageal fistula. ( 30301608 )
2018
30
Relationships between hospital and surgeon operative volumes and outcomes of esophageal atresia/tracheoesophageal fistula repair. ( 30401496 )
2018
31
Closer location of the tracheoesophageal fistula to the carina in newborns with esophageal atresia and VACTERL association. ( 30503021 )
2018
32
Challenging surgical dogma in the management of proximal esophageal atresia with distal tracheoesophageal fistula: Outcomes from the Midwest Pediatric Surgery Consortium. ( 28599967 )
2018
33
A chest tube may not be needed after surgical repair of esophageal atresia and tracheoesophageal fistula. ( 30051148 )
2018
34
Vocal cord paralysis appears to be an acquired lesion in children with repaired esophageal atresia/tracheoesophageal fistula. ( 30055738 )
2018
35
Esophageal Atresia and Tracheoesophageal Fistula. ( 30110585 )
2018
36
Successful endobronchial treatment of a non-healing tracheoesophageal fistula from a previous histoplasmosis capsulatum infection using decellularized porcine urinary bladder matrix†. ( 30151101 )
2018
37
Postoperative Stridor following Repair of Tracheoesophageal Fistula: A Case Report. ( 28334968 )
2018
38
Gastrointestinal: Tracheoesophageal fistula secondary to pressure necrosis from tracheostomy tube balloon cuff. ( 29469236 )
2018
39
Congenital H-type tracheoesophageal fistula in adults. ( 30026978 )
2018
40
Management of Malignant Tracheoesophageal Fistula. ( 30054077 )
2018
41
Successful endoscopic closure of chronic nonmalignant tracheoesophageal fistula by use of a novel circumfistular endoscopic submucosal dissection and ligation strategy. ( 30128403 )
2018
42
Chronic tracheoesophageal fistula successfully treated using Amplatzer septal occluder. ( 30199899 )
2018
43
Total Parenteral Nutrition Lipid Emulsion Pleural and Pericardial Effusions May Present Similar Chylothorax with Milky White Chest Tube Output after Tracheoesophageal Fistula Repair. ( 30269706 )
2018
44
Penetrating shrapnel injury to the chest presenting as a delayed tracheoesophageal fistula (TEF). A case report. ( 30310839 )
2018
45
Acquired tracheoesophageal fistula repair, due to prolonged mechanical ventilation, in patient with double incomplete aortic arch. ( 30375809 )
2018
46
Factors Associated with Recurrence of Tracheoesophageal Fistula. ( 30430797 )
2018
47
Total Parenteral Nutrition Lipid Emulsion Pleural and Pericardial Effusions May Present Similar Chylothorax with Milky White Chest Tube Output after Tracheoesophageal Fistula Repair. ( 30454497 )
2018
48
Using a Sternocleidomastoid Muscle Flap to Close an Iatrogenic Tracheoesophageal Fistula in a Patient With Advanced Laryngeal Cancer: A Case Report and Literature Review. ( 30516563 )
2018
49
Not all neonates with oesophageal atresia and tracheoesophageal fistula are a surgical emergency. ( 30518493 )
2018
50
Surgery for a large tracheoesophageal fistula using extracorporeal membrane oxygenation. ( 29221332 )
2017

Variations for Tracheoesophageal Fistula

ClinVar genetic disease variations for Tracheoesophageal Fistula:

6 (show all 26)
# Gene Variation Type Significance SNP ID Assembly Location
1 BRIP1 NM_032043.2(BRIP1): c.2392C> T (p.Arg798Ter) single nucleotide variant Conflicting interpretations of pathogenicity rs137852986 GRCh37 Chromosome 17, 59793412: 59793412
2 BRIP1 NM_032043.2(BRIP1): c.2392C> T (p.Arg798Ter) single nucleotide variant Conflicting interpretations of pathogenicity rs137852986 GRCh38 Chromosome 17, 61716051: 61716051
3 FANCC NM_000136.2(FANCC): c.1642C> T (p.Arg548Ter) single nucleotide variant Pathogenic/Likely pathogenic rs104886457 GRCh37 Chromosome 9, 97864024: 97864024
4 FANCC NM_000136.2(FANCC): c.1642C> T (p.Arg548Ter) single nucleotide variant Pathogenic/Likely pathogenic rs104886457 GRCh38 Chromosome 9, 95101742: 95101742
5 BRCA2 NM_000059.3(BRCA2): c.5682C> G (p.Tyr1894Ter) single nucleotide variant Pathogenic rs41293497 GRCh37 Chromosome 13, 32914174: 32914174
6 BRCA2 NM_000059.3(BRCA2): c.5682C> G (p.Tyr1894Ter) single nucleotide variant Pathogenic rs41293497 GRCh38 Chromosome 13, 32340037: 32340037
7 BRCA2 NM_000059.3(BRCA2): c.7480C> T (p.Arg2494Ter) single nucleotide variant Pathogenic rs80358972 GRCh37 Chromosome 13, 32930609: 32930609
8 BRCA2 NM_000059.3(BRCA2): c.7480C> T (p.Arg2494Ter) single nucleotide variant Pathogenic rs80358972 GRCh38 Chromosome 13, 32356472: 32356472
9 BRCA2 NM_000059.3(BRCA2): c.9117G> A (p.Pro3039=) single nucleotide variant Pathogenic rs28897756 GRCh37 Chromosome 13, 32954050: 32954050
10 BRCA2 NM_000059.3(BRCA2): c.9117G> A (p.Pro3039=) single nucleotide variant Pathogenic rs28897756 GRCh38 Chromosome 13, 32379913: 32379913
11 BRCA2 NM_000059.3(BRCA2): c.145G> T (p.Glu49Ter) single nucleotide variant Pathogenic rs80358435 GRCh37 Chromosome 13, 32893291: 32893291
12 BRCA2 NM_000059.3(BRCA2): c.145G> T (p.Glu49Ter) single nucleotide variant Pathogenic rs80358435 GRCh38 Chromosome 13, 32319154: 32319154
13 BRCA2 NM_000059.3(BRCA2): c.5857G> T (p.Glu1953Ter) single nucleotide variant Pathogenic rs80358814 GRCh37 Chromosome 13, 32914349: 32914349
14 BRCA2 NM_000059.3(BRCA2): c.5857G> T (p.Glu1953Ter) single nucleotide variant Pathogenic rs80358814 GRCh38 Chromosome 13, 32340212: 32340212
15 BRCA2 NM_000059.3(BRCA2): c.7051G> A (p.Ala2351Thr) single nucleotide variant Uncertain significance rs80358930 GRCh37 Chromosome 13, 32929041: 32929041
16 BRCA2 NM_000059.3(BRCA2): c.7051G> A (p.Ala2351Thr) single nucleotide variant Uncertain significance rs80358930 GRCh38 Chromosome 13, 32354904: 32354904
17 BRCA2 NM_000059.3(BRCA2): c.7625C> T (p.Thr2542Met) single nucleotide variant Uncertain significance rs80358989 GRCh37 Chromosome 13, 32931886: 32931886
18 BRCA2 NM_000059.3(BRCA2): c.7625C> T (p.Thr2542Met) single nucleotide variant Uncertain significance rs80358989 GRCh38 Chromosome 13, 32357749: 32357749
19 PALB2 NM_024675.3(PALB2): c.11C> T (p.Pro4Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs45619737 GRCh38 Chromosome 16, 23641147: 23641147
20 PALB2 NM_024675.3(PALB2): c.11C> T (p.Pro4Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs45619737 GRCh37 Chromosome 16, 23652468: 23652468
21 PALB2 NM_024675.3(PALB2): c.2773G> C (p.Val925Leu) single nucleotide variant Uncertain significance rs180177125 GRCh38 Chromosome 16, 23624070: 23624070
22 PALB2 NM_024675.3(PALB2): c.2773G> C (p.Val925Leu) single nucleotide variant Uncertain significance rs180177125 GRCh37 Chromosome 16, 23635391: 23635391
23 PALB2 NM_024675.3(PALB2): c.1240C> T (p.Arg414Ter) single nucleotide variant Pathogenic rs180177100 GRCh38 Chromosome 16, 23635306: 23635306
24 PALB2 NM_024675.3(PALB2): c.1240C> T (p.Arg414Ter) single nucleotide variant Pathogenic rs180177100 GRCh37 Chromosome 16, 23646627: 23646627
25 PALB2 NM_024675.3(PALB2): c.3549C> A (p.Tyr1183Ter) single nucleotide variant Pathogenic rs118203998 GRCh38 Chromosome 16, 23603471: 23603471
26 PALB2 NM_024675.3(PALB2): c.3549C> A (p.Tyr1183Ter) single nucleotide variant Pathogenic rs118203998 GRCh37 Chromosome 16, 23614792: 23614792

Expression for Tracheoesophageal Fistula

Search GEO for disease gene expression data for Tracheoesophageal Fistula.

Pathways for Tracheoesophageal Fistula

GO Terms for Tracheoesophageal Fistula

Cellular components related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.77 BRCA2 BRIP1 CHD7 FANCA FANCC GLI3
2 nucleoplasm GO:0005654 9.32 BRCA2 BRIP1 CHD7 DCTN5 FANCA FANCC
3 Fanconi anaemia nuclear complex GO:0043240 9.16 FANCA FANCC

Biological processes related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.99 BRCA2 GLI3 MYCN SHH SOX2 ZIC3
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 CHD7 GLI3 HOXD13 MYCN NOG SHH
3 DNA repair GO:0006281 9.96 BRCA2 BRIP1 FANCA FANCC PALB2
4 negative regulation of gene expression GO:0010629 9.95 BRIP1 MYCN NOG SHH
5 in utero embryonic development GO:0001701 9.91 CHD7 GLI3 NOG PALB2
6 regulation of cell proliferation GO:0042127 9.88 FANCA GLI3 HOXD13 SHH
7 lung development GO:0030324 9.83 GLI3 SHH ZIC3
8 forebrain development GO:0030900 9.81 GLI3 SHH SOX2
9 camera-type eye development GO:0043010 9.8 CHD7 GLI3 SHH
10 roof of mouth development GO:0060021 9.79 CHD7 GLI3 SHH
11 negative regulation of cell differentiation GO:0045596 9.79 GLI3 NOG SHH
12 negative regulation of canonical Wnt signaling pathway GO:0090090 9.78 GLI3 NOG SHH SOX2
13 embryonic limb morphogenesis GO:0030326 9.77 GLI3 HOXD13 SHH
14 inner ear development GO:0048839 9.77 GLI3 SHH SOX2
15 somatic stem cell population maintenance GO:0035019 9.76 NOG SOX2 ZIC3
16 anterior/posterior pattern specification GO:0009952 9.73 GLI3 HOXD13 SHH ZIC3
17 nucleotide-excision repair GO:0006289 9.72 BRCA2 BRIP1 FANCC
18 female gonad development GO:0008585 9.7 BRCA2 FANCA
19 limb morphogenesis GO:0035108 9.7 GLI3 HOXD13
20 dorsal/ventral pattern formation GO:0009953 9.7 GLI3 NOG SHH
21 neuronal stem cell population maintenance GO:0097150 9.69 FANCC SOX2
22 positive regulation of neuroblast proliferation GO:0002052 9.69 GLI3 SHH
23 aorta development GO:0035904 9.69 CHD7 DCTN5
24 lung morphogenesis GO:0060425 9.68 NOG SHH
25 spinal cord motor neuron differentiation GO:0021522 9.68 GLI3 SHH
26 regulation of neuronal synaptic plasticity GO:0048168 9.68 S100B SYP
27 male genitalia development GO:0030539 9.68 HOXD13 SHH
28 embryonic digestive tract morphogenesis GO:0048557 9.67 GLI3 SHH
29 embryonic morphogenesis GO:0048598 9.67 GLI3 SHH
30 somite development GO:0061053 9.67 NOG SHH
31 inner cell mass cell proliferation GO:0001833 9.65 BRCA2 PALB2
32 negative thymic T cell selection GO:0045060 9.65 GLI3 SHH
33 positive regulation of alpha-beta T cell differentiation GO:0046638 9.64 GLI3 SHH
34 artery development GO:0060840 9.63 GLI3 SHH
35 embryonic organ development GO:0048568 9.63 GLI3 PALB2 SHH
36 anatomical structure formation involved in morphogenesis GO:0048646 9.58 GLI3 NOG SHH
37 spinal cord dorsal/ventral patterning GO:0021513 9.57 GLI3 SHH
38 embryonic digit morphogenesis GO:0042733 9.56 GLI3 HOXD13 NOG SHH
39 hindgut morphogenesis GO:0007442 9.54 GLI3 SHH
40 prostate gland development GO:0030850 9.5 GLI3 HOXD13 SHH
41 negative regulation of alpha-beta T cell differentiation GO:0046639 9.49 GLI3 SHH
42 limb development GO:0060173 9.46 CHD7 GLI3 NOG SHH
43 central nervous system development GO:0007417 9.35 CHD7 GLI3 NOG S100B SHH
44 pattern specification process GO:0007389 9.02 GLI3 HOXD13 NOG SHH ZIC3
45 transcription by RNA polymerase II GO:0006366 10.06 GLI3 HOXD13 MYCN SOX2 ZIC3
46 cellular response to DNA damage stimulus GO:0006974 10.03 BRCA2 BRIP1 FANCA FANCC PALB2

Molecular functions related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.61 BRCA2 BRIP1 CHD7 GLI3 HOXD13 MYCN
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.55 CHD7 GLI3 HOXD13 MYCN ZIC3
3 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.02 GLI3 HOXD13 MYCN SOX2 ZIC3
4 protein binding GO:0005515 10.13 BRCA2 BRIP1 CHD7 DCTN5 FANCA FANCC

Sources for Tracheoesophageal Fistula

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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