MCID: TRC040
MIFTS: 47

Tracheoesophageal Fistula

Categories: Rare diseases

Aliases & Classifications for Tracheoesophageal Fistula

MalaCards integrated aliases for Tracheoesophageal Fistula:

Name: Tracheoesophageal Fistula 53 29 55 6
Tracheoesophageal Fistula with or Without Esophageal Atresia 53
Te Fistula 53
Tef 53

Classifications:



Summaries for Tracheoesophageal Fistula

NIH Rare Diseases : 53 Tracheoesophageal fistula (TEF) is a life-threatening condition in which there is an abnormal connection between the esophagus and trachea (windpipe). The esophagus and trachea run next to each other through the chest cavity. The esophagus carries food and saliva to the stomach, while the trachea carries air to the lungs. TEF can lead to severe and fatal lung complications. Saliva and gastric secretions can be aspirated into the lungs, and normal swallowing and digestion of food cannot occur. Most affected people are diagnosed immediately after birth or during infancy. Symptoms may include frothy bubbles of mucus in the mouth and nose; episodes of coughing and choking; and worsening symptoms during feeding. TEF may be isolated, or it may occur with other physical or developmental abnormalities (most commonly, esophageal atresia). In many cases the cause is unknown but it has been associated with some chromosome disorders. In some cases it may be acquired later in life after a cancer, infection, ruptured diverticula, or trauma. Treatment includes immediate surgical repair with survival rates of almost 100%.

MalaCards based summary : Tracheoesophageal Fistula, also known as tracheoesophageal fistula with or without esophageal atresia, is related to tracheoesophageal fistula with or without esophageal atresia and esophageal atresia. An important gene associated with Tracheoesophageal Fistula is BRCA2 (BRCA2, DNA Repair Associated), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Chks in Checkpoint Regulation. The drug threonine has been mentioned in the context of this disorder. Affiliated tissues include trachea, lung and heart, and related phenotypes are Decreased ionizing radiation sensitivity and Increased viability with MLN4924 (a NAE inhibitor)

Wikipedia : 76 A tracheoesophageal fistula (TEF, or TOF; see spelling differences) is an abnormal connection (fistula)... more...

Related Diseases for Tracheoesophageal Fistula

Diseases related to Tracheoesophageal Fistula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 tracheoesophageal fistula with or without esophageal atresia 34.5 BRCA2 FANCC PALB2
2 esophageal atresia 31.7 CHD7 GLI3 MYCN SOX2
3 fanconi anemia, complementation group b 29.1 FANCA FANCB FANCC FANCD2 FANCE FANCF
4 esophageal atresia/tracheoesophageal fistula 12.6
5 isolated tracheoesophageal fistula 12.3
6 tracheoesophageal fistula symphalangism 12.1
7 martinez-frias syndrome 11.9
8 vater/vacterl association 11.6
9 feingold syndrome 1 11.5
10 vacterl association with hydrocephalus 11.3
11 vacterl association, x-linked, with or without hydrocephalus 11.3
12 feingold syndrome 2 11.1
13 mitchell-riley syndrome 11.1
14 esophagitis 11.0
15 bap1 tumor predisposition syndrome 10.7 BRCA2 PALB2
16 tumor predisposition syndrome 10.4 BRCA2 PALB2
17 laryngitis 10.2
18 duodenitis 10.2
19 fanconi anemia, complementation group d2 10.2 BRCA2 FANCD2
20 lymphoma 10.2
21 tracheomalacia 10.2
22 tracheal stenosis 10.2
23 diaphragmatic hernia, congenital 10.2
24 lung agenesis 10.2
25 duodenal atresia 10.2
26 ampulla of vater adenocarcinoma 10.1 BRCA2 SOX2
27 esophageal cancer 10.1
28 cervicitis 10.1
29 brain cancer 10.1 BRCA2 GLI3 MYCN SOX2
30 lung cancer 10.1
31 tracheal agenesis 10.1
32 gastroesophageal reflux 10.1
33 right aortic arch 10.0
34 hypertrophic pyloric stenosis 10.0
35 pyloric stenosis 10.0
36 mediastinitis 10.0
37 respiratory failure 10.0
38 heart disease 10.0
39 thyroiditis 10.0
40 laryngeal cleft 10.0
41 anus, imperforate 10.0
42 dysphagia 10.0
43 maternal uniparental disomy of chromosome 16 9.9 FANCA SLX4
44 aspiration pneumonia 9.9
45 aspergillosis 9.9
46 dextrocardia 9.9
47 pneumonia 9.9
48 congenital tracheal stenosis 9.9
49 b-cell lymphomas 9.9
50 vacterl association 9.9

Graphical network of the top 20 diseases related to Tracheoesophageal Fistula:



Diseases related to Tracheoesophageal Fistula

Symptoms & Phenotypes for Tracheoesophageal Fistula

GenomeRNAi Phenotypes related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased ionizing radiation sensitivity GR00232-A-1 9.81 BRCA2 BRIP1 CHD7 FANCA FANCB FANCD2
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.77 BRCA2 BRIP1 ERCC4 FANCA FANCC FANCD2
3 Synthetic lethal with Ras GR00018-A-0 9.17 BRCA2 CHD7 FANCA FANCC FANCD2 GLI3

MGI Mouse Phenotypes related to Tracheoesophageal Fistula:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.41 PALB2 SLX4 SOX2 BRCA2 BRIP1 CHD7
2 growth/size/body region MP:0005378 10.33 BRCA2 CHD7 ERCC4 FANCA FANCB FANCD2
3 endocrine/exocrine gland MP:0005379 10.32 BRCA2 BRIP1 CHD7 FANCA FANCB FANCC
4 mortality/aging MP:0010768 10.24 FANCI FANCL GLI3 MID1 MYCN PALB2
5 homeostasis/metabolism MP:0005376 10.21 FANCL GLI3 MYCN SLX4 SOX2 BRCA2
6 embryo MP:0005380 10.19 BRCA2 CHD7 FANCA FANCL GLI3 MID1
7 reproductive system MP:0005389 10.03 SLX4 SOX2 BRCA2 BRIP1 CHD7 FANCA
8 nervous system MP:0003631 9.96 BRCA2 BRIP1 CHD7 FANCD2 GLI3 MID1
9 limbs/digits/tail MP:0005371 9.95 GLI3 MYCN PALB2 SLX4 BRCA2 CHD7
10 neoplasm MP:0002006 9.87 BRCA2 BRIP1 FANCA FANCD2 FANCF PALB2
11 skeleton MP:0005390 9.61 BRCA2 CHD7 FANCA FANCC FANCL GLI3
12 vision/eye MP:0005391 9.23 CHD7 FANCA FANCD2 FANCL GLI3 MYCN

Drugs & Therapeutics for Tracheoesophageal Fistula

Drugs for Tracheoesophageal Fistula (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 threonine Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Endoscopic Closure of Tracheoesophageal Fistulas With Occluder Device Terminated NCT01153061 Phase 4
2 Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood Gases Unknown status NCT01467245 Not Applicable
3 Trichloroacetic Acid for Endoscopic Tracho-esophageal Fistula Repair Unknown status NCT01287312 Not Applicable
4 Chewing in Children With Repaired Esophageal Atresia-tracheoesophageal Fistula Completed NCT03026491
5 Prospective Data Collection of Patients < 6 Months of Age Undergoing Thoracoscopic Surgery Completed NCT02033772
6 High-resolution Esophageal Manometry Completed NCT03415893
7 Ultrasound Guided Percutaneous Tracheostomy Compared to Bronchoscopy Guided Percutaneous Tracheostomy Completed NCT02084862 Not Applicable
8 National Register of Oesophageal Atresia Recruiting NCT02883725
9 Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients Recruiting NCT03455881
10 A Physiological Study to Determine the Enteral Threonine Requirements in Infants Aged 1 to 6 Months Enrolling by invitation NCT02364843 Not Applicable

Search NIH Clinical Center for Tracheoesophageal Fistula

Genetic Tests for Tracheoesophageal Fistula

Genetic tests related to Tracheoesophageal Fistula:

# Genetic test Affiliating Genes
1 Tracheoesophageal Fistula 29 BRCA2 BRIP1 CHD7 ERCC4 FANCA FANCB FANCC FANCD2 FANCE FANCF FANCG FANCI FANCL FANCM GLI3 MID1 MYCN PALB2 RAD51C SLX4 SOX2

Anatomical Context for Tracheoesophageal Fistula

MalaCards organs/tissues related to Tracheoesophageal Fistula:

41
Trachea, Lung, Heart, Thyroid, Colon, Bone, Lymph Node

Publications for Tracheoesophageal Fistula

Articles related to Tracheoesophageal Fistula:

(show top 50) (show all 709)
# Title Authors Year
1
Structural airway abnormalities contribute to dysphagia in children with esophageal atresia and tracheoesophageal fistula. ( 29429770 )
2018
2
Experience of diagnosis and treatment of 31 H-type tracheoesophageal fistula in a single clinical center. ( 29855692 )
2018
3
Pneumomediastinum following iatrogenic pharyngeal perforation during tracheoesophageal fistula repair. ( 29628860 )
2018
4
Repair of congenital esophageal atresia with tracheoesophageal fistula repair in Ontario over the last 20years: Volume and outcomes. ( 29519572 )
2018
5
A new method of tracheoesophageal fistula treatment: Using an atrial septal defect occluder device for closure-The first Turkish experience. ( 29730753 )
2018
6
Pneumothorax in a preterm during tracheoesophageal fistula repair: Challenges in diagnosis and management. ( 29416484 )
2018
7
Endoscopic closure of tracheoesophageal fistula for tuberculosis with an over-the-scope-clip. ( 29931992 )
2018
8
Tracheoesophageal fistula diagnosis during open tracheostomy. ( 29487265 )
2018
9
Pre- and post-operative visualization of neonatal esophageal atresia/tracheoesophageal fistula via magnetic resonance imaging. ( 29399473 )
2018
10
Endoscopic management of recurrent tracheoesophageal fistula induced by chronic use of nonsteroidal anti-inflammatory drugs: a case report and review of the literature. ( 29742066 )
2018
11
A hybrid endoscopic technique to close tracheoesophageal fistula. ( 29905178 )
2018
12
Basic Knowledge of Tracheoesophageal Fistula and Esophageal Atresia. ( 29373345 )
2018
13
Characteristics and outcomes of children with ductal-dependent congenital heart disease and esophageal atresia/tracheoesophageal fistula: A multi-institutional analysis. ( 29325785 )
2018
14
Neurodevelopmental outcomes of infants with esophageal atresia and tracheoesophageal fistula. ( 29429769 )
2018
15
Successful endoscopic closure of tracheoesophageal fistula using a Padlock ClipTM. ( 29442487 )
2018
16
Bevacizumab-induced tracheoesophageal fistula in a patient suffering from lung cancer with bulky subcarinal lymph node: a case report. ( 29581622 )
2018
17
Postoperative pain management for tracheoesophageal fistula repair using transverse, in-plane, ultrasound guided paravertebral technique in a 2a8^kg neonate. ( 29980000 )
2018
18
Oral feeding outcomes in infants with esophageal atresia and tracheoesophageal fistula. ( 29519575 )
2018
19
A Hem-o-Lok-Induced Tracheoesophageal Fistula Cured By Temporary Airway Stenting Modified With Three-Dimensional Printing. ( 29763597 )
2018
20
Trans-Tracheal Cyanoacrylate Glue Injection for the Management of Malignant Tracheoesophageal Fistula. ( 29941936 )
2018
21
Successful repair using thymus pedicle flap for tracheoesophageal fistula: a case report. ( 29796790 )
2018
22
Pharyngocutaneous and tracheoesophageal fistula closure using supraclavicular artery island flap. ( 29602967 )
2018
23
Successful treatment of tracheoesophageal fistula using a covered esophageal stent. ( 29761794 )
2018
24
Intentional tracheoesophageal fistula cannulation for gastric decompression in type C esophageal atresia. ( 29484765 )
2018
25
Surgical management of tracheoesophageal fistula. ( 29707512 )
2018
26
Esophageal Atresia with Tracheoesophageal Fistula and Gastroesophageal Reflux in Children: Dental Considerations and Case Report. ( 29750630 )
2018
27
The utility of the oxygen reserve indexa8c in a neonate undergoing re-exploration of a tracheoesophageal fistula. ( 29643560 )
2018
28
Surgery for a large tracheoesophageal fistula using extracorporeal membrane oxygenation. ( 29221332 )
2017
29
Preliminary Study of Video-Based Pediatric Endoscopic Surgical Skill Assessment Using a Neonatal Esophageal Atresia/Tracheoesophageal Fistula Model. ( 27858521 )
2017
30
Review of surgical and anesthetic management for esophageal atresia with tracheoesophageal fistula, unilateral pulmonary agenesis and dextrocardia. ( 28417152 )
2017
31
Deep endoscopic submucosal dissection of a refractory tracheoesophageal fistula using clip-and-line traction: a successful closure. ( 28992634 )
2017
32
Using Bronchoscopy to Detect Acquired Tracheoesophageal Fistula in Mechanically Ventilated Patients. ( 29430408 )
2017
33
Successful Thoracic Duct Embolization for Treatment of anA Iatrogenic Left Chylothorax inA aA Neonate after Repair of a Tracheoesophageal Fistula and Esophageal Atresia. ( 28841955 )
2017
34
Intraoperative acidosis and hypercapnia during thoracoscopic repair of congenital diaphragmatic hernia and esophageal atresia/tracheoesophageal fistula. ( 28631351 )
2017
35
Oesophageal atresia with no distal tracheoesophageal fistula: Management and outcomes from a population-based cohort. ( 27894760 )
2017
36
Gastric Function in Children with Oesophageal Atresia and Tracheoesophageal Fistula. ( 28447027 )
2017
37
Surveillance in Patients With Esophageal Atresia/Tracheoesophageal Fistula. ( 28144844 )
2017
38
Chewing Function in Children with Repaired Esophageal Atresia-Tracheoesophageal Fistula. ( 29212093 )
2017
39
Magnetic Twin Stent for Short-Term Palliation of Acquired Nonmalignant Tracheoesophageal Fistula. ( 28838507 )
2017
40
Management of acquired nonmalignant tracheoesophageal fistula: Surgical pearls. ( 28916214 )
2017
41
Isolated tracheoesophageal fistula versus esophageal atresia - Early morbidity and short-term outcome. A single institution series. ( 28166998 )
2017
42
Ineffective Ventilation in A Neonate with A Large Pre-Carinal Tracheoesophageal Fistula and Bilateral Pneumonitis-Microcuff Endotracheal Tube to Our Rescue! ( 28083500 )
2017
43
Clinical Study of Congenital Esophageal Stenosis: Comparison according to Association of Esophageal Atresia and Tracheoesophageal Fistula. ( 28730131 )
2017
44
Unusual case of tracheoesophageal fistula caused by impacted denture. ( 28676178 )
2017
45
Changes in quality of life from infancy to school age after esophagoesophagostomy for tracheoesophageal fistula: thoracotomy versus thoracoscopy. ( 28831606 )
2017
46
Treatment of tracheoesophageal fistula after laryngectomy by a customized tracheal prosthesis. ( 29193191 )
2017
47
Tuberculous Tracheoesophageal Fistula: A Rare Entity. ( 28918864 )
2017
48
Simple Technique of Bridging Wide Gap in Esophageal Atresia with Tracheoesophageal Fistula - &amp;quot;Surgical Innovation&amp;quot;. ( 28694583 )
2017
49
Successful endoscopic closure of a refractory button-battery tracheoesophageal fistula in a 3-year child using endoscopic submucosal dissection of the surrounding mucosa. ( 28662536 )
2017
50
Learning curve for the thoracoscopic repair of esophageal atresia with tracheoesophageal fistula. ( 28718991 )
2017

Variations for Tracheoesophageal Fistula

ClinVar genetic disease variations for Tracheoesophageal Fistula:

6
(show all 18)
# Gene Variation Type Significance SNP ID Assembly Location
1 FANCC NM_000136.2(FANCC): c.1642C> T (p.Arg548Ter) single nucleotide variant Pathogenic/Likely pathogenic rs104886457 GRCh37 Chromosome 9, 97864024: 97864024
2 FANCC NM_000136.2(FANCC): c.1642C> T (p.Arg548Ter) single nucleotide variant Pathogenic/Likely pathogenic rs104886457 GRCh38 Chromosome 9, 95101742: 95101742
3 BRCA2 NM_000059.3(BRCA2): c.5682C> G (p.Tyr1894Ter) single nucleotide variant Pathogenic rs41293497 GRCh37 Chromosome 13, 32914174: 32914174
4 BRCA2 NM_000059.3(BRCA2): c.5682C> G (p.Tyr1894Ter) single nucleotide variant Pathogenic rs41293497 GRCh38 Chromosome 13, 32340037: 32340037
5 BRCA2 NM_000059.3(BRCA2): c.7480C> T (p.Arg2494Ter) single nucleotide variant Pathogenic rs80358972 GRCh37 Chromosome 13, 32930609: 32930609
6 BRCA2 NM_000059.3(BRCA2): c.7480C> T (p.Arg2494Ter) single nucleotide variant Pathogenic rs80358972 GRCh38 Chromosome 13, 32356472: 32356472
7 BRCA2 NM_000059.3(BRCA2): c.9117G> A (p.Pro3039=) single nucleotide variant Pathogenic rs28897756 GRCh37 Chromosome 13, 32954050: 32954050
8 BRCA2 NM_000059.3(BRCA2): c.9117G> A (p.Pro3039=) single nucleotide variant Pathogenic rs28897756 GRCh38 Chromosome 13, 32379913: 32379913
9 BRCA2 NM_000059.3(BRCA2): c.145G> T (p.Glu49Ter) single nucleotide variant Pathogenic rs80358435 GRCh37 Chromosome 13, 32893291: 32893291
10 BRCA2 NM_000059.3(BRCA2): c.145G> T (p.Glu49Ter) single nucleotide variant Pathogenic rs80358435 GRCh38 Chromosome 13, 32319154: 32319154
11 BRCA2 NM_000059.3(BRCA2): c.5857G> T (p.Glu1953Ter) single nucleotide variant Pathogenic rs80358814 GRCh37 Chromosome 13, 32914349: 32914349
12 BRCA2 NM_000059.3(BRCA2): c.5857G> T (p.Glu1953Ter) single nucleotide variant Pathogenic rs80358814 GRCh38 Chromosome 13, 32340212: 32340212
13 PALB2 NM_024675.3(PALB2): c.1240C> T (p.Arg414Ter) single nucleotide variant Pathogenic rs180177100 GRCh38 Chromosome 16, 23635306: 23635306
14 PALB2 NM_024675.3(PALB2): c.1240C> T (p.Arg414Ter) single nucleotide variant Pathogenic rs180177100 GRCh37 Chromosome 16, 23646627: 23646627
15 PALB2 NM_024675.3(PALB2): c.3549C> A (p.Tyr1183Ter) single nucleotide variant Pathogenic rs118203998 GRCh38 Chromosome 16, 23603471: 23603471
16 PALB2 NM_024675.3(PALB2): c.3549C> A (p.Tyr1183Ter) single nucleotide variant Pathogenic rs118203998 GRCh37 Chromosome 16, 23614792: 23614792
17 46;XY;t(15;17)(q24;q21.3)dn Translocation Pathogenic
18 46;XY;t(6;8)(q13;q13)dn Translocation Pathogenic

Expression for Tracheoesophageal Fistula

Search GEO for disease gene expression data for Tracheoesophageal Fistula.

Pathways for Tracheoesophageal Fistula

Pathways related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 BRCA2 BRIP1 ERCC4 FANCA FANCB FANCC
2
Show member pathways
12.53 BRCA2 ERCC4 FANCA FANCC FANCD2 FANCE
3 12.35 BRCA2 BRIP1 ERCC4 FANCA FANCB FANCD2
4
Show member pathways
12.14 BRCA2 BRIP1 ERCC4 PALB2 RAD51C SLX4
5
Show member pathways
12.01 BRCA2 BRIP1 PALB2 RAD51C SLX4
6
Show member pathways
11.78 BRCA2 FANCA FANCC FANCD2 FANCE FANCF
7 11.47 BRCA2 BRIP1 ERCC4 FANCA FANCB FANCC
8 11.16 FANCA FANCC FANCD2 FANCE FANCF FANCG

GO Terms for Tracheoesophageal Fistula

Cellular components related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.91 BRCA2 BRIP1 CHD7 ERCC4 FANCA FANCB
2 nuclear chromosome, telomeric region GO:0000784 9.54 BRCA2 ERCC4 SLX4
3 Holliday junction resolvase complex GO:0048476 9.32 RAD51C SLX4
4 ERCC4-ERCC1 complex GO:0070522 9.26 ERCC4 SLX4
5 Fanconi anaemia nuclear complex GO:0043240 9.17 FANCA FANCB FANCC FANCE FANCF FANCG
6 nucleus GO:0005634 10.13 BRCA2 BRIP1 CHD7 ERCC4 FANCA FANCB

Biological processes related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.85 BRCA2 FANCA FANCL GLI3
2 DNA repair GO:0006281 9.83 BRCA2 BRIP1 ERCC4 FANCA FANCB FANCC
3 DNA recombination GO:0006310 9.78 BRCA2 PALB2 RAD51C SLX4
4 double-strand break repair via homologous recombination GO:0000724 9.72 BRCA2 ERCC4 PALB2 RAD51C SLX4
5 nucleotide-excision repair GO:0006289 9.71 BRCA2 ERCC4 FANCC SLX4
6 DNA synthesis involved in DNA repair GO:0000731 9.67 BRCA2 BRIP1 PALB2 RAD51C
7 neuronal stem cell population maintenance GO:0097150 9.63 FANCC FANCD2 SOX2
8 gamete generation GO:0007276 9.61 FANCC FANCD2 FANCL
9 female gonad development GO:0008585 9.59 BRCA2 FANCA
10 male meiosis I GO:0007141 9.58 BRCA2 RAD51C
11 brain morphogenesis GO:0048854 9.58 FANCC FANCD2
12 regulation of regulatory T cell differentiation GO:0045589 9.57 FANCA FANCD2
13 resolution of meiotic recombination intermediates GO:0000712 9.56 ERCC4 SLX4
14 strand displacement GO:0000732 9.56 BRCA2 BRIP1 PALB2 RAD51C
15 inner cell mass cell proliferation GO:0001833 9.54 BRCA2 PALB2
16 telomere maintenance via recombination GO:0000722 9.52 BRCA2 RAD51C
17 negative regulation of telomere maintenance via telomere lengthening GO:1904357 9.51 ERCC4 SLX4
18 regulation of CD40 signaling pathway GO:2000348 9.49 FANCA FANCD2
19 interstrand cross-link repair GO:0036297 9.36 ERCC4 FANCA FANCB FANCC FANCD2 FANCE
20 cellular response to DNA damage stimulus GO:0006974 10.03 BRCA2 BRIP1 ERCC4 FANCA FANCB FANCC

Molecular functions related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.85 BRCA2 BRIP1 CHD7 ERCC4 FANCI GLI3
2 protein binding GO:0005515 9.62 BRCA2 BRIP1 CHD7 ERCC4 FANCA FANCB
3 single-stranded DNA binding GO:0003697 9.5 BRCA2 ERCC4 RAD51C
4 DNA polymerase binding GO:0070182 9.37 FANCD2 FANCI
5 crossover junction endodeoxyribonuclease activity GO:0008821 9.26 RAD51C SLX4
6 endodeoxyribonuclease activity GO:0004520 9.13 ERCC4 RAD51C SLX4

Sources for Tracheoesophageal Fistula

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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