MCID: TRC040
MIFTS: 48

Tracheoesophageal Fistula

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Tracheoesophageal Fistula

MalaCards integrated aliases for Tracheoesophageal Fistula:

Name: Tracheoesophageal Fistula 54 30 56 6
Tracheoesophageal Fistula with or Without Esophageal Atresia 54
Te Fistula 54
Tef 54

Classifications:



Summaries for Tracheoesophageal Fistula

NIH Rare Diseases : 54 Tracheoesophageal fistula (TEF) is a life-threatening condition in which there is an abnormal connection between the esophagus and trachea (windpipe). The esophagus and trachea run next to each other through the chest cavity. The esophagus carries food and saliva to the stomach, while the trachea carries air to the lungs. TEF can lead to severe and fatal lung complications. Saliva and gastric secretions can be aspirated into the lungs, and normal swallowing and digestion of food cannot occur. Most affected people are diagnosed immediately after birth or during infancy. Symptoms may include frothy bubbles of mucus in the mouth and nose; episodes of coughing and choking; and worsening symptoms during feeding. TEF may be isolated, or it may occur with other physical or developmental abnormalities (most commonly, esophageal atresia). In many cases the cause is unknown but it has been associated with some chromosome disorders. In some cases it may be acquired later in life after a cancer, infection, ruptured diverticula, or trauma. Treatment includes immediate surgical repair with survival rates of almost 100%.

MalaCards based summary : Tracheoesophageal Fistula, also known as tracheoesophageal fistula with or without esophageal atresia, is related to tracheoesophageal fistula with or without esophageal atresia and isolated tracheoesophageal fistula. An important gene associated with Tracheoesophageal Fistula is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Ectoderm Differentiation and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Iodine and threonine have been mentioned in the context of this disorder. Affiliated tissues include trachea, lung and kidney, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Wikipedia : 77 A tracheoesophageal fistula (TEF, or TOF; see spelling differences) is an abnormal connection (fistula)... more...

Related Diseases for Tracheoesophageal Fistula

Diseases related to Tracheoesophageal Fistula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 tracheoesophageal fistula with or without esophageal atresia 34.3 BRCA2 FANCC PALB2
2 isolated tracheoesophageal fistula 34.2 BRCA2 FANCC PALB2
3 vater/vacterl association 33.3 HOXD13 ZIC3
4 esophageal atresia 30.3 CHD7 GLI3 LPP MYCN NOG SHH
5 vacterl association 30.3 HOXD13 LPP SHH ZIC3
6 esophageal atresia/tracheoesophageal fistula 12.8
7 tracheoesophageal fistula symphalangism 12.3
8 martinez-frias syndrome 12.1
9 feingold syndrome 1 11.7
10 vacterl association with hydrocephalus 11.5
11 vacterl association, x-linked, with or without hydrocephalus 11.5
12 feingold syndrome 2 11.3
13 fanconi anemia, complementation group b 11.3
14 mitchell-riley syndrome 11.3
15 plasminogen deficiency, type i 11.1
16 gastrointestinal defects and immunodeficiency syndrome 11.1
17 orofaciodigital syndrome viii 11.1
18 tracheal disease 11.1
19 fusariosis 11.1
20 ametropic amblyopia 11.1
21 diaphragmatic eventration 11.1
22 diaphragm disease 11.1
23 intestinal atresia 11.1
24 rectal disease 11.1
25 eumycotic mycetoma 11.1
26 anterior scleritis 11.1
27 sclerosing keratitis 11.1
28 dermatomycosis 11.1
29 anus disease 11.1
30 esophageal disease 11.1
31 mediastinitis 11.1
32 dyskinesia of esophagus 11.1
33 deep keratitis 11.1
34 lung agenesis 10.5
35 lymphoma 10.5
36 tracheomalacia 10.4
37 pancreatic neuroendocrine tumor 10.4 BRCA2 PALB2
38 esophageal cancer 10.4
39 pancreatic cancer 3 10.4 DCTN5 PALB2
40 gastroesophageal reflux 10.3
41 diaphragmatic hernia, congenital 10.3
42 duodenal atresia 10.3
43 tracheal stenosis 10.3
44 lung cancer 10.3
45 hypertrophic pyloric stenosis 10.3
46 pyloric stenosis 10.3
47 pneumonia 10.3
48 tracheal agenesis 10.3
49 pancreas adenocarcinoma 10.3 BRCA2 PALB2 SHH
50 hereditary breast ovarian cancer syndrome 10.2 BRCA2 BRIP1 PALB2

Graphical network of the top 20 diseases related to Tracheoesophageal Fistula:



Diseases related to Tracheoesophageal Fistula

Symptoms & Phenotypes for Tracheoesophageal Fistula

GenomeRNAi Phenotypes related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.1 BRCA2 BRIP1 FANCA FANCC PALB2 ZIC3

MGI Mouse Phenotypes related to Tracheoesophageal Fistula:

47 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.4 BRCA2 BRIP1 CHD7 FANCA FANCC GLI3
2 growth/size/body region MP:0005378 10.31 BRCA2 CHD7 DCTN5 FANCA GLI3 HOXD13
3 behavior/neurological MP:0005386 10.3 BRCA2 CHD7 DCTN5 MYCN PALB2 S100B
4 embryo MP:0005380 10.3 BRCA2 CHD7 FANCA GLI3 HOXD13 MYCN
5 endocrine/exocrine gland MP:0005379 10.25 BRCA2 BRIP1 CHD7 FANCA FANCC GLI3
6 homeostasis/metabolism MP:0005376 10.25 BRCA2 BRIP1 CHD7 FANCA GLI3 LPP
7 cardiovascular system MP:0005385 10.24 CHD7 DCTN5 FANCA GLI3 MYCN NOG
8 craniofacial MP:0005382 10.23 CHD7 DCTN5 FANCA GLI3 MYCN NOG
9 mortality/aging MP:0010768 10.23 BRCA2 CHD7 FANCA GLI3 HOXD13 LPP
10 digestive/alimentary MP:0005381 10.22 BRCA2 CHD7 GLI3 HOXD13 MYCN NOG
11 nervous system MP:0003631 10.18 BRCA2 BRIP1 CHD7 DCTN5 GLI3 MYCN
12 limbs/digits/tail MP:0005371 10.13 BRCA2 CHD7 GLI3 HOXD13 MYCN NOG
13 reproductive system MP:0005389 10.13 BRCA2 BRIP1 CHD7 FANCA FANCC GLI3
14 integument MP:0010771 10.1 BRCA2 GLI3 HOXD13 NOG PALB2 S100B
15 normal MP:0002873 10.02 BRCA2 GLI3 MYCN NOG S100B SHH
16 hearing/vestibular/ear MP:0005377 10 CHD7 GLI3 NOG SHH SOX2 ZIC3
17 skeleton MP:0005390 9.93 BRCA2 CHD7 DCTN5 FANCA FANCC GLI3
18 neoplasm MP:0002006 9.91 BRCA2 BRIP1 FANCA PALB2 SHH SOX2
19 respiratory system MP:0005388 9.8 CHD7 GLI3 MYCN NOG SHH SOX2
20 vision/eye MP:0005391 9.32 CHD7 DCTN5 FANCA GLI3 HOXD13 MYCN
21 taste/olfaction MP:0005394 9.26 GLI3 NOG SHH SOX2

Drugs & Therapeutics for Tracheoesophageal Fistula

Drugs for Tracheoesophageal Fistula (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Not Applicable 7553-56-2 807
2 threonine Not Applicable
3 cadexomer iodine Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Transanastomotic Tube for Proximal Esophageal Atresia With Distal Tracheoesophageal Fistula Repair Recruiting NCT03730454 Phase 4
2 Endoscopic Closure of Tracheoesophageal Fistulas With Occluder Device Terminated NCT01153061 Phase 4
3 Adipose Derived SVF for Aero-digestive Fistulae Not yet recruiting NCT03792360 Phase 1 SVF (Stromal Vascular Fraction)
4 Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood Gases Unknown status NCT01467245 Not Applicable
5 Trichloroacetic Acid for Endoscopic Tracho-esophageal Fistula Repair Unknown status NCT01287312 Not Applicable
6 Caregivers of Children With Repaired Esophageal Atresia-tracheoesophageal Fistula Completed NCT03889041
7 Chewing in Children With Repaired Esophageal Atresia-tracheoesophageal Fistula Completed NCT03026491
8 Prospective Data Collection of Patients < 6 Months of Age Undergoing Thoracoscopic Surgery Completed NCT02033772
9 High-resolution Esophageal Manometry Completed NCT03415893
10 Ultrasound Guided Percutaneous Tracheostomy Compared to Bronchoscopy Guided Percutaneous Tracheostomy Completed NCT02084862 Not Applicable
11 National Register of Oesophageal Atresia Recruiting NCT02883725
12 Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients Recruiting NCT03455881
13 Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries Recruiting NCT03666767
14 A Physiological Study to Determine the Enteral Threonine Requirements in Infants Aged 1 to 6 Months Enrolling by invitation NCT02364843 Not Applicable
15 A Metal Bare Stent With 125 Iodine (125I)Seeds for the Treatment of Malignant Central Airway Stenosis Not yet recruiting NCT03944408 Not Applicable

Search NIH Clinical Center for Tracheoesophageal Fistula

Genetic Tests for Tracheoesophageal Fistula

Genetic tests related to Tracheoesophageal Fistula:

# Genetic test Affiliating Genes
1 Tracheoesophageal Fistula 30

Anatomical Context for Tracheoesophageal Fistula

MalaCards organs/tissues related to Tracheoesophageal Fistula:

42
Trachea, Lung, Kidney, Pancreas, Colon, Thyroid, B Cells

Publications for Tracheoesophageal Fistula

Articles related to Tracheoesophageal Fistula:

(show top 50) (show all 1139)
# Title Authors Year
1
Surgical management of newborns with combined tracheoesophageal fistula, esophageal atresia, and duodenal obstruction. ( 30855354 )
2019
2
Relationships between hospital and surgeon operative volumes and outcomes of esophageal atresia/tracheoesophageal fistula repair. ( 30401496 )
2019
3
Treatment of two newborns with esophageal atresia and distal tracheoesophageal fistula complicated by gastric perforation: choosing the simple way. ( 30714508 )
2019
4
Postoperative noninvasive ventilation and complications in esophageal atresia-tracheoesophageal fistula. ( 30814037 )
2019
5
Outcomes of multi-gestational pregnancies affected by esophageal atresia - tracheoesophageal fistula. ( 31103274 )
2019
6
Tracheoesophageal Fistula in a Patient with Advanced Non-Small Cell Lung Cancer Who Received Chemoradiotherapy and Ramucirumab. ( 30579551 )
2019
7
Not all neonates with oesophageal atresia and tracheoesophageal fistula are a surgical emergency. ( 30518493 )
2019
8
Tracheoesophageal Fistula in a Patient With Advanced NSCLC Who Received Chemoradiotherapy and Ramucirumab. ( 30579552 )
2019
9
Outcomes of kidney transplants in pediatric patients with the vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, limb abnormalities association. ( 30597716 )
2019
10
Anaesthetic management of tracheoesophageal fistula with accidental ingestion of button battery cell. ( 30745617 )
2019
11
Broncho-endoscopic Repair of Tracheoesophageal Fistula. ( 30973758 )
2019
12
Diode laser treatment in a case of congenital tracheoesophageal fistula in a young dog. ( 31080257 )
2019
13
Structural airway abnormalities contribute to dysphagia in children with esophageal atresia and tracheoesophageal fistula. ( 29429770 )
2018
14
A chest tube may not be needed after surgical repair of esophageal atresia and tracheoesophageal fistula. ( 30051148 )
2018
15
Vocal cord paralysis appears to be an acquired lesion in children with repaired esophageal atresia/tracheoesophageal fistula. ( 30055738 )
2018
16
Esophageal Atresia and Tracheoesophageal Fistula. ( 30110585 )
2018
17
Vocal cord dysfunction following esophageal atresia and tracheoesophageal fistula (EA/TEF) repair. ( 30274710 )
2018
18
Prevalence and natural history of scoliosis and associated congenital vertebral anomalies in patients operated for esophageal atresia with or without tracheoesophageal fistula. ( 30301608 )
2018
19
Closer location of the tracheoesophageal fistula to the carina in newborns with esophageal atresia and VACTERL association. ( 30503021 )
2018
20
Developmental Status of Children Operated for Esophageal Atresia with or without Tracheoesophageal Fistula Along with Maternal Stress, Their Quality of life, and Coping Abilities at AIIMS, New Delhi. ( 30597492 )
2018
21
Challenging surgical dogma in the management of proximal esophageal atresia with distal tracheoesophageal fistula: Outcomes from the Midwest Pediatric Surgery Consortium. ( 28599967 )
2018
22
Learning curve for the thoracoscopic repair of esophageal atresia with tracheoesophageal fistula. ( 28718991 )
2018
23
Chewing Function in Children with Repaired Esophageal Atresia-Tracheoesophageal Fistula. ( 29212093 )
2018
24
Characteristics and outcomes of children with ductal-dependent congenital heart disease and esophageal atresia/tracheoesophageal fistula: A multi-institutional analysis. ( 29325785 )
2018
25
Basic Knowledge of Tracheoesophageal Fistula and Esophageal Atresia. ( 29373345 )
2018
26
Pre- and post-operative visualization of neonatal esophageal atresia/tracheoesophageal fistula via magnetic resonance imaging. ( 29399473 )
2018
27
Neurodevelopmental outcomes of infants with esophageal atresia and tracheoesophageal fistula. ( 29429769 )
2018
28
Intentional tracheoesophageal fistula cannulation for gastric decompression in type C esophageal atresia. ( 29484765 )
2018
29
Repair of congenital esophageal atresia with tracheoesophageal fistula repair in Ontario over the last 20years: Volume and outcomes. ( 29519572 )
2018
30
Oral feeding outcomes in infants with esophageal atresia and tracheoesophageal fistula. ( 29519575 )
2018
31
Esophageal Atresia with Tracheoesophageal Fistula and Gastroesophageal Reflux in Children: Dental Considerations and Case Report. ( 29750630 )
2018
32
Esophageal Atresia with or without Tracheoesophageal Fistula (EA/TEF): Association of Different EA/TEF Subtypes with Specific Co-occurring Congenital Anomalies and Implications for Diagnostic Workup. ( 28061520 )
2018
33
Successful endobronchial treatment of a non-healing tracheoesophageal fistula from a previous histoplasmosis capsulatum infection using decellularized porcine urinary bladder matrix†. ( 30151101 )
2018
34
Pneumothorax in a preterm during tracheoesophageal fistula repair: Challenges in diagnosis and management. ( 29416484 )
2018
35
Penetrating shrapnel injury to the chest presenting as a delayed tracheoesophageal fistula (TEF). A case report. ( 30310839 )
2018
36
Acquired tracheoesophageal fistula repair, due to prolonged mechanical ventilation, in patient with double incomplete aortic arch. ( 30375809 )
2018
37
Factors Associated with Recurrence of Tracheoesophageal Fistula. ( 30430797 )
2018
38
Using a Sternocleidomastoid Muscle Flap to Close an Iatrogenic Tracheoesophageal Fistula in a Patient With Advanced Laryngeal Cancer: A Case Report and Literature Review. ( 30516563 )
2018
39
H-type tracheoesophageal fistula diagnosed on video fluoroscopy swallowing study. ( 30567184 )
2018
40
Congenital high airway obstruction with tracheoesophageal fistula: A case report. ( 30572501 )
2018
41
Endoscopically assisted transstomal primary repair of an acquired tracheoesophageal fistula. ( 30575042 )
2018
42
Neural monitoring during H-type tracheoesophageal fistula division: A way to decrease recurrent laryngeal nerve injury? ( 30594308 )
2018
43
Prolonged Intubation Induced Tracheoesophageal Fistula in Suspected Meningococcal Sepsis with ARDS: A Case Report. ( 31065149 )
2018
44
Postoperative Stridor following Repair of Tracheoesophageal Fistula: A Case Report. ( 28334968 )
2018
45
Tuberculous Tracheoesophageal Fistula: A Rare Entity. ( 28918864 )
2018
46
Treatment of tracheoesophageal fistula after laryngectomy by a customized tracheal prosthesis. ( 29193191 )
2018
47
Successful endoscopic closure of tracheoesophageal fistula using a Padlock ClipTM. ( 29442487 )
2018
48
Gastrointestinal: Tracheoesophageal fistula secondary to pressure necrosis from tracheostomy tube balloon cuff. ( 29469236 )
2018
49
Tracheoesophageal fistula diagnosis during open tracheostomy. ( 29487265 )
2018
50
Bevacizumab-induced tracheoesophageal fistula in a patient suffering from lung cancer with bulky subcarinal lymph node: a case report. ( 29581622 )
2018

Variations for Tracheoesophageal Fistula

ClinVar genetic disease variations for Tracheoesophageal Fistula:

6 (show all 28)
# Gene Variation Type Significance SNP ID Assembly Location
1 BRIP1 NM_032043.2(BRIP1): c.2392C> T (p.Arg798Ter) single nucleotide variant Conflicting interpretations of pathogenicity rs137852986 GRCh37 Chromosome 17, 59793412: 59793412
2 BRIP1 NM_032043.2(BRIP1): c.2392C> T (p.Arg798Ter) single nucleotide variant Conflicting interpretations of pathogenicity rs137852986 GRCh38 Chromosome 17, 61716051: 61716051
3 FANCC NM_000136.2(FANCC): c.1642C> T (p.Arg548Ter) single nucleotide variant Pathogenic/Likely pathogenic rs104886457 GRCh37 Chromosome 9, 97864024: 97864024
4 FANCC NM_000136.2(FANCC): c.1642C> T (p.Arg548Ter) single nucleotide variant Pathogenic/Likely pathogenic rs104886457 GRCh38 Chromosome 9, 95101742: 95101742
5 BRCA2 NM_000059.3(BRCA2): c.5682C> G (p.Tyr1894Ter) single nucleotide variant Pathogenic rs41293497 GRCh37 Chromosome 13, 32914174: 32914174
6 BRCA2 NM_000059.3(BRCA2): c.5682C> G (p.Tyr1894Ter) single nucleotide variant Pathogenic rs41293497 GRCh38 Chromosome 13, 32340037: 32340037
7 BRCA2 NM_000059.3(BRCA2): c.7480C> T (p.Arg2494Ter) single nucleotide variant Pathogenic rs80358972 GRCh37 Chromosome 13, 32930609: 32930609
8 BRCA2 NM_000059.3(BRCA2): c.7480C> T (p.Arg2494Ter) single nucleotide variant Pathogenic rs80358972 GRCh38 Chromosome 13, 32356472: 32356472
9 BRCA2 NM_000059.3(BRCA2): c.9117G> A (p.Pro3039=) single nucleotide variant Pathogenic rs28897756 GRCh37 Chromosome 13, 32954050: 32954050
10 BRCA2 NM_000059.3(BRCA2): c.9117G> A (p.Pro3039=) single nucleotide variant Pathogenic rs28897756 GRCh38 Chromosome 13, 32379913: 32379913
11 BRCA2 NM_000059.3(BRCA2): c.145G> T (p.Glu49Ter) single nucleotide variant Pathogenic rs80358435 GRCh37 Chromosome 13, 32893291: 32893291
12 BRCA2 NM_000059.3(BRCA2): c.145G> T (p.Glu49Ter) single nucleotide variant Pathogenic rs80358435 GRCh38 Chromosome 13, 32319154: 32319154
13 BRCA2 NM_000059.3(BRCA2): c.5857G> T (p.Glu1953Ter) single nucleotide variant Pathogenic rs80358814 GRCh37 Chromosome 13, 32914349: 32914349
14 BRCA2 NM_000059.3(BRCA2): c.5857G> T (p.Glu1953Ter) single nucleotide variant Pathogenic rs80358814 GRCh38 Chromosome 13, 32340212: 32340212
15 BRCA2 NM_000059.3(BRCA2): c.7051G> A (p.Ala2351Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs80358930 GRCh37 Chromosome 13, 32929041: 32929041
16 BRCA2 NM_000059.3(BRCA2): c.7051G> A (p.Ala2351Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs80358930 GRCh38 Chromosome 13, 32354904: 32354904
17 BRCA2 NM_000059.3(BRCA2): c.7625C> T (p.Thr2542Met) single nucleotide variant Conflicting interpretations of pathogenicity rs80358989 GRCh37 Chromosome 13, 32931886: 32931886
18 BRCA2 NM_000059.3(BRCA2): c.7625C> T (p.Thr2542Met) single nucleotide variant Conflicting interpretations of pathogenicity rs80358989 GRCh38 Chromosome 13, 32357749: 32357749
19 PALB2 NM_024675.3(PALB2): c.11C> T (p.Pro4Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs45619737 GRCh38 Chromosome 16, 23641147: 23641147
20 PALB2 NM_024675.3(PALB2): c.11C> T (p.Pro4Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs45619737 GRCh37 Chromosome 16, 23652468: 23652468
21 PALB2 NM_024675.3(PALB2): c.2773G> C (p.Val925Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs180177125 GRCh38 Chromosome 16, 23624070: 23624070
22 PALB2 NM_024675.3(PALB2): c.2773G> C (p.Val925Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs180177125 GRCh37 Chromosome 16, 23635391: 23635391
23 PALB2 NM_024675.3(PALB2): c.1240C> T (p.Arg414Ter) single nucleotide variant Pathogenic rs180177100 GRCh38 Chromosome 16, 23635306: 23635306
24 PALB2 NM_024675.3(PALB2): c.1240C> T (p.Arg414Ter) single nucleotide variant Pathogenic rs180177100 GRCh37 Chromosome 16, 23646627: 23646627
25 PALB2 NM_024675.3(PALB2): c.3549C> A (p.Tyr1183Ter) single nucleotide variant Pathogenic rs118203998 GRCh38 Chromosome 16, 23603471: 23603471
26 PALB2 NM_024675.3(PALB2): c.3549C> A (p.Tyr1183Ter) single nucleotide variant Pathogenic rs118203998 GRCh37 Chromosome 16, 23614792: 23614792
27 46;XY;t(15;17)(q24;q21.3)dn Translocation Pathogenic
28 46;XY;t(6;8)(q13;q13)dn Translocation Pathogenic

Expression for Tracheoesophageal Fistula

Search GEO for disease gene expression data for Tracheoesophageal Fistula.

Pathways for Tracheoesophageal Fistula

GO Terms for Tracheoesophageal Fistula

Cellular components related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.77 BRCA2 BRIP1 CHD7 FANCA FANCC GLI3
2 nucleoplasm GO:0005654 9.32 BRCA2 BRIP1 CHD7 DCTN5 FANCA FANCC
3 Fanconi anaemia nuclear complex GO:0043240 9.16 FANCA FANCC

Biological processes related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.99 BRCA2 GLI3 MYCN SHH SOX2 ZIC3
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 CHD7 GLI3 HOXD13 MYCN NOG SHH
3 DNA repair GO:0006281 9.96 BRCA2 BRIP1 FANCA FANCC PALB2
4 negative regulation of gene expression GO:0010629 9.95 BRIP1 MYCN NOG SHH
5 in utero embryonic development GO:0001701 9.91 CHD7 GLI3 NOG PALB2
6 regulation of cell proliferation GO:0042127 9.88 FANCA GLI3 HOXD13 SHH
7 lung development GO:0030324 9.83 GLI3 SHH ZIC3
8 forebrain development GO:0030900 9.81 GLI3 SHH SOX2
9 camera-type eye development GO:0043010 9.8 CHD7 GLI3 SHH
10 roof of mouth development GO:0060021 9.79 CHD7 GLI3 SHH
11 negative regulation of cell differentiation GO:0045596 9.79 GLI3 NOG SHH
12 negative regulation of canonical Wnt signaling pathway GO:0090090 9.78 GLI3 NOG SHH SOX2
13 embryonic limb morphogenesis GO:0030326 9.77 GLI3 HOXD13 SHH
14 inner ear development GO:0048839 9.77 GLI3 SHH SOX2
15 somatic stem cell population maintenance GO:0035019 9.76 NOG SOX2 ZIC3
16 anterior/posterior pattern specification GO:0009952 9.73 GLI3 HOXD13 SHH ZIC3
17 nucleotide-excision repair GO:0006289 9.72 BRCA2 BRIP1 FANCC
18 female gonad development GO:0008585 9.7 BRCA2 FANCA
19 limb morphogenesis GO:0035108 9.7 GLI3 HOXD13
20 dorsal/ventral pattern formation GO:0009953 9.7 GLI3 NOG SHH
21 neuronal stem cell population maintenance GO:0097150 9.69 FANCC SOX2
22 positive regulation of neuroblast proliferation GO:0002052 9.69 GLI3 SHH
23 aorta development GO:0035904 9.69 CHD7 DCTN5
24 lung morphogenesis GO:0060425 9.68 NOG SHH
25 spinal cord motor neuron differentiation GO:0021522 9.68 GLI3 SHH
26 regulation of neuronal synaptic plasticity GO:0048168 9.68 S100B SYP
27 male genitalia development GO:0030539 9.68 HOXD13 SHH
28 embryonic digestive tract morphogenesis GO:0048557 9.67 GLI3 SHH
29 embryonic morphogenesis GO:0048598 9.67 GLI3 SHH
30 somite development GO:0061053 9.67 NOG SHH
31 inner cell mass cell proliferation GO:0001833 9.65 BRCA2 PALB2
32 negative thymic T cell selection GO:0045060 9.65 GLI3 SHH
33 positive regulation of alpha-beta T cell differentiation GO:0046638 9.64 GLI3 SHH
34 artery development GO:0060840 9.63 GLI3 SHH
35 embryonic organ development GO:0048568 9.63 GLI3 PALB2 SHH
36 anatomical structure formation involved in morphogenesis GO:0048646 9.58 GLI3 NOG SHH
37 spinal cord dorsal/ventral patterning GO:0021513 9.57 GLI3 SHH
38 embryonic digit morphogenesis GO:0042733 9.56 GLI3 HOXD13 NOG SHH
39 hindgut morphogenesis GO:0007442 9.54 GLI3 SHH
40 prostate gland development GO:0030850 9.5 GLI3 HOXD13 SHH
41 negative regulation of alpha-beta T cell differentiation GO:0046639 9.49 GLI3 SHH
42 limb development GO:0060173 9.46 CHD7 GLI3 NOG SHH
43 transcription by RNA polymerase II GO:0006366 9.36 HOXD13
44 central nervous system development GO:0007417 9.35 CHD7 GLI3 NOG S100B SHH
45 pattern specification process GO:0007389 9.02 GLI3 HOXD13 NOG SHH ZIC3
46 cellular response to DNA damage stimulus GO:0006974 10.03 BRCA2 BRIP1 FANCA FANCC PALB2

Molecular functions related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.35 CHD7 GLI3 HOXD13 MYCN ZIC3
2 DNA binding GO:0003677 9.28 BRCA2 BRIP1 CHD7 GLI3 HOXD13 MYCN
3 protein binding GO:0005515 10.03 BRCA2 BRIP1 CHD7 DCTN5 FANCA FANCC

Sources for Tracheoesophageal Fistula

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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