MCID: TRC097
MIFTS: 38

Tracheomalacia

Categories: Bone diseases, Fetal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Tracheomalacia

MalaCards integrated aliases for Tracheomalacia:

Name: Tracheomalacia 12 29 6 44 15 73
Congenital Tracheomalacia 12 53 59 44
Congenital Major Airway Collapse 53 59
Tracheomalacia, Congenital 53
Type 1 Tracheomalacia 53

Characteristics:

Orphanet epidemiological data:

59
congenital tracheomalacia
Age of onset: Infancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:0060313
ICD10 33 Q32.0
SNOMED-CT 68 95467005
Orphanet 59 ORPHA95430
MESH via Orphanet 45 C557675
UMLS via Orphanet 74 C0392109
ICD10 via Orphanet 34 Q32.0

Summaries for Tracheomalacia

NIH Rare Diseases : 53 Congenital tracheomalacia is when an infant is born with weak cartilage around the windpipe (trachea) that makes it difficult to keep the airway open. The trachea can collapse when breathing out. Symptoms vary from mild to severe and may include noisy breathing (stridor), shortness of breath, difficulty breathing, and bluish skin (cyanotic spells). Symptoms typically worsen during periods of activity. Tracheomalacia can occur on its own or along with other airway problems. It can also occur with congenital abnormalities that affect other parts of the body. Tracheomalacia often resolves on its own by the second year of life. Treatment of symptoms may include humidified air, chest physical therapy, or continuous positive airway pressure (CPAP) for respiratory distress. Severe tracheomalacia may need to be treated with surgery.

MalaCards based summary : Tracheomalacia, also known as congenital tracheomalacia, is related to tracheal stenosis and esophageal atresia/tracheoesophageal fistula. An important gene associated with Tracheomalacia is TEF (TEF, PAR BZIP Transcription Factor). Affiliated tissues include trachea, skin and bone.

Disease Ontology : 12 A tracheal disease characterized by flaccidity of the tracheal support cartilage.

Wikipedia : 76 Tracheomalacia is a condition where the cartilage that keeps the airway (trachea) open is soft such that... more...

Related Diseases for Tracheomalacia

Diseases related to Tracheomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 tracheal stenosis 30.2 SLC22A4 TEF
2 esophageal atresia/tracheoesophageal fistula 29.6 TBX4 TEF
3 bronchomalacia 11.4
4 xia-gibbs syndrome 11.0
5 kleefstra syndrome 11.0
6 2q37 deletion syndrome 11.0
7 tracheoesophageal fistula with or without esophageal atresia 10.5
8 esophageal atresia 10.5
9 chitayat syndrome 10.3
10 tracheoesophageal fistula 10.3
11 goiter 10.3
12 laryngomalacia 10.1
13 asthma 10.1
14 tracheobronchial stenosis, congenital 10.1
15 congenital tracheal stenosis 10.1
16 cystic fibrosis 10.0
17 achalasia 10.0
18 mounier-kuhn syndrome 10.0
19 tracheobronchomalacia 10.0
20 trachea leiomyoma 10.0 SLC22A4 TEF
21 gastroesophageal reflux 10.0
22 tracheobronchomegaly 10.0
23 pulmonary disease, chronic obstructive 10.0
24 bronchopulmonary dysplasia 10.0
25 sleep apnea 10.0
26 relapsing polychondritis 10.0
27 aortic aneurysm 10.0
28 amyotrophic lateral sclerosis 1 9.8
29 larsen syndrome 9.8
30 marfan syndrome 9.8
31 kniest dysplasia 9.8
32 pancreas, annular 9.8
33 pheochromocytoma 9.8
34 tetralogy of fallot 9.8
35 renal hypodysplasia/aplasia 1 9.8
36 vater/vacterl association 9.8
37 achalasia, familial esophageal 9.8
38 hallermann-streiff syndrome 9.8
39 aspergillosis 9.8
40 adult respiratory distress syndrome 9.8
41 multinodular goiter 9.8
42 scoliosis 9.8
43 respiratory failure 9.8
44 megaesophagus 9.8
45 endemic goiter 9.8
46 vacterl association 9.8
47 ventricular septal defect 9.8
48 lateral sclerosis 9.8
49 aspiration pneumonitis 9.8
50 adenoma 9.8

Graphical network of the top 20 diseases related to Tracheomalacia:



Diseases related to Tracheomalacia

Symptoms & Phenotypes for Tracheomalacia

Drugs & Therapeutics for Tracheomalacia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study to Assess the Safety, Tolerability and Potential Efficacy of a Tracheal Replacement Consisting of a Tissue-engineered Tracheal Scaffold With Seeded Mesenchymal Cells Suspended NCT02949414 Phase 1
2 Tracheal Mechanics During Bronchoscopy Completed NCT00536315
3 Tracheobronchomalacia: Treatment Outcomes Completed NCT00550602
4 Airway Pressure and Lumen Changes During NIV With Flexible Bronchoscopy Completed NCT03666403 Not Applicable
5 In Infants With Laryngomalacia, Does Acid-Blocking Medication Improve Respiratory Symptoms? Withdrawn NCT02700087 Not Applicable ranitidine or famotidine;Placebo

Search NIH Clinical Center for Tracheomalacia

Cochrane evidence based reviews: tracheomalacia

Genetic Tests for Tracheomalacia

Genetic tests related to Tracheomalacia:

# Genetic test Affiliating Genes
1 Tracheomalacia 29

Anatomical Context for Tracheomalacia

MalaCards organs/tissues related to Tracheomalacia:

41
Trachea, Skin, Bone, Thyroid, Smooth Muscle, Pancreas

Publications for Tracheomalacia

Articles related to Tracheomalacia:

(show top 50) (show all 284)
# Title Authors Year
1
Helical multi-detector CT scan as a tool for diagnosing tracheomalacia in children. ( 30485735 )
2019
2
Successful Management of Acquired Tracheomalacia of Patients With Amyotrophic Lateral Sclerosis: A Report of Three Cases. ( 29765893 )
2018
3
Airway management during general anesthesia in an intellectually disabled patient with undiagnosed tracheomalacia. ( 29744388 )
2018
4
Achalasia with massive oesophageal dilation causing tracheomalacia and asthma symptoms. ( 29321968 )
2018
5
Serial fiber optic bronchoscopy (FOB) to predict the need of tracheostomy in tracheomalacia after thyroidectomy in long standing goiter. ( 29524827 )
2018
6
Pediatric tracheomalacia and the perioperative anesthetic management of thoracoscopic posterior tracheopexy. ( 29962064 )
2018
7
Thoracoscopic posterior tracheopexy during primary esophageal atresia repair: a new approach to prevent tracheomalacia complications. ( 29804792 )
2018
8
Descending Aortopexy and Posterior Tracheopexy for Severe Tracheomalacia and Left Mainstem Bronchomalacia. ( 29524603 )
2018
9
Tracheobronchoplasty for tracheomalacia. ( 29707504 )
2018
10
Bronchoscopic assessments and clinical outcomes in pediatric patients with tracheomalacia and bronchomalacia. ( 29124401 )
2018
11
Minimally Invasive Surgical Approach for Posterior Tracheopexy to Treat Severe Tracheomalacia: Lessons Learned from Initial Case Series. ( 29975595 )
2018
12
Can high flow nasal cannula be used in a pediatric patient with tracheomalacia? ( 29136346 )
2018
13
Huge thyroid adenoma with tracheomalacia. ( 30147923 )
2018
14
Laryngomalacia, Tracheomalacia and Bronchomalacia. ( 29622320 )
2018
15
Thoracoscopic posterior tracheopexy for tracheomalacia: A minimally invasive technique. ( 30316404 )
2018
16
Tracheomalacia with tracheal bronchus. ( 30348930 )
2018
17
Preclinical assessment of resorbable silk splints for the treatment of pediatric tracheomalacia. ( 30408198 )
2018
18
Clinical Characteristics and Associated Congenital Lesions with Tracheomalacia in Infants. ( 30426955 )
2018
19
Aortopexy for tracheomalacia via a suprasternal incision. ( 30518491 )
2018
20
Ultralow Dose Dynamic Expiratory Computed Tomography for Evaluation of Tracheomalacia. ( 30531547 )
2018
21
Computational modeling of airway instability and collapse in tracheomalacia. ( 28424075 )
2017
22
Aberrant right subclavian artery syndrome manifesting as focal tracheomalacia. ( 28474661 )
2017
23
Posterior Tracheopexy for Severe Tracheomalacia Associated with Esophageal Atresia (EA): Primary Treatment at the Time of Initial EA Repair versus Secondary Treatment. ( 29379786 )
2017
24
Posterior tracheopexy for severe tracheomalacia. ( 28385426 )
2017
25
Three-dimensional printing of external airway splints for tracheomalacia. ( 28449431 )
2017
26
Mediastinal Tracheostoma for Treatment of Tracheostenosis after Tracheostomy in a Patient with Mucopolysaccharidosis-Induced Tracheomalacia. ( 29158939 )
2017
27
Esophageal Atresia/Tracheoesophageal Fistula Repair Complicated by Tracheomalacia: A Case Report of Successful Management of Respiratory Distress Using Caudal Morphine. ( 28410264 )
2017
28
External airway splint to treat tracheomalacia following laryngotracheal reconstruction. ( 28167015 )
2017
29
Use of a biodegradable, oversized stent in a child with tracheomalacia secondary to vascular external compression. ( 28281415 )
2017
30
Bronchoscopy as a screening tool for symptomatic tracheomalacia in oesophageal atresia. ( 29217321 )
2017
31
Home high-flow nasal cannula as a treatment for severe tracheomalacia: A pediatric case report. ( 28504355 )
2017
32
Treatment of Severe Acquired Tracheomalacia With a Patient-Specific, 3D-Printed, Permanent Tracheal Splint. ( 28125750 )
2017
33
Paediatric tracheomalacia - A review of clinical features and comparison of diagnostic imaging techniques. ( 28583509 )
2017
34
All that wheezes is not asthma: adult tracheomalacia resulting from innominate artery compression. ( 27377076 )
2016
35
Tracheomalacia in a patient with tracheobronchial amyloidosis. ( 27478146 )
2016
36
Tracheomalacia and recurrent exacerbations of chronic obstructive pulmonary disease: a case report and review of the literature. ( 27987292 )
2016
37
Management of Life-Threatening Tracheal Stenosis and Tracheomalacia in Patients with Mucopolysaccharidoses. ( 27450368 )
2016
38
Tracheal suspension by using 3-dimensional printed personalized scaffold in a patient with tracheomalacia. ( 28066613 )
2016
39
Pediatric tracheomalacia. ( 27301602 )
2016
40
Tracheomalacia Due to Esophageal Achalasia. ( 27364977 )
2016
41
Recurrent spontaneous pneumomediastinum in a child with tracheomalacia. ( 27723958 )
2016
42
Posterior Mesh Tracheoplasty for Cervical Tracheomalacia: A Novel Trachea-Preserving Technique. ( 26694287 )
2016
43
Ex vivo tracheomalacia model with 3D-printed external tracheal splint. ( 27531619 )
2016
44
External bioresorbable airway rigidification to treat refractory localized tracheomalacia. ( 26971821 )
2016
45
Annular Pancreas, Severe Tracheomalacia and Bronchomalacia in a Preterm Boy with Vacterl Association. ( 29485824 )
2016
46
Nitinol stent insertion in tracheomalacia. ( 26944511 )
2016
47
Intraoperatively diagnosed tracheal tear during a parathyroidec- tomy with previously undiagnosed tracheomalacia: a case report. ( 29873990 )
2016
48
Transtracheal single-point stent fixation in posttracheotomy tracheomalacia under cone-beam computer tomography guidance by transmural suturing with the Berci needle - a perspective on a new tool to avoid stent migration of Dumon stents. ( 26045666 )
2015
49
Thoracoscopic aortopexy for tracheomalacia. ( 25231705 )
2015
50
Airway obstruction due to tracheomalacia caused by innominate artery compression and a kyphotic cervical spine. ( 25639407 )
2015

Variations for Tracheomalacia

Expression for Tracheomalacia

Search GEO for disease gene expression data for Tracheomalacia.

Pathways for Tracheomalacia

GO Terms for Tracheomalacia

Sources for Tracheomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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