MCID: TRC115
MIFTS: 31

Tracheopathia Osteoplastica

Categories: Bone diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Tracheopathia Osteoplastica

MalaCards integrated aliases for Tracheopathia Osteoplastica:

Name: Tracheopathia Osteoplastica 57 20 58 70
Tracheobronchopathia Osteochondroplastica 57 20 58 54
Tracheobronchopathia Osteoplastica 20 70
Cartilaginous or Bony Projections into the Tracheobronchial Lumen 20

Characteristics:

Orphanet epidemiological data:

58
tracheobronchopathia osteochondroplastica
Age of onset: Adult,Childhood,Elderly; Age of death: normal life expectancy;

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant


HPO:

31
tracheopathia osteoplastica:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 58  
Rare respiratory diseases


External Ids:

OMIM® 57 189961
ICD10 via Orphanet 33 J98.0
UMLS via Orphanet 71 C0520538 C3887588
Orphanet 58 ORPHA3348
MedGen 41 C3887588
UMLS 70 C0520538 C3887588

Summaries for Tracheopathia Osteoplastica

GARD : 20 Tracheobronchopathia osteoplastica (TO) is a rare condition of the large airways. It is characterized by the presence of multiple growths (nodules) made of bone and cartilage tissue, in the submucosa of the tracheobronchial wall. The nodules protrude into the spaces inside the trachea and bronchi, which can lead to airway obstruction. Affected people may have persisting or recurrent respiratory symptoms, and/or recurrent infections. The cause of TO is not currently known. There is no specific treatment to prevent the formation of nodules. Laser therapy or removal of the nodules may be needed in some cases.

MalaCards based summary : Tracheopathia Osteoplastica, also known as tracheobronchopathia osteochondroplastica, is related to silicosis and multinodular goiter. An important gene associated with Tracheopathia Osteoplastica is TPO (Thyroid Peroxidase). Affiliated tissues include trachea, lung and heart, and related phenotypes are productive cough and tracheal calcification

More information from OMIM: 189961

Related Diseases for Tracheopathia Osteoplastica

Diseases related to Tracheopathia Osteoplastica via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 silicosis 10.4
2 multinodular goiter 10.3
3 respiratory failure 10.3
4 adult respiratory distress syndrome 10.3
5 goiter 10.3
6 amyloidosis 10.3
7 sarcoidosis 1 10.3
8 mycobacterium tuberculosis 1 10.3
9 middle lobe syndrome 10.3
10 tracheal disease 10.3
11 laryngitis 10.3
12 rhinitis 10.3
13 atrophic rhinitis 10.3
14 deficiency anemia 10.1
15 dermatomyositis 10.1
16 iron deficiency anemia 10.1
17 iron metabolism disease 10.1
18 tracheal stenosis 10.1
19 intermediate coronary syndrome 10.1
20 bronchiectasis 10.1
21 rare tumor 10.1
22 hair whorl 10.1
23 immunoglobulin alpha deficiency 10.1
24 nodular goiter 10.1
25 laryngeal tuberculosis 10.1
26 calcinosis 10.1
27 exostosis 10.1
28 skin carcinoma 10.1
29 mucoepidermoid carcinoma 10.1
30 pneumonia 10.1
31 bronchitis 10.1
32 lung lymphoma 10.1
33 end stage renal disease 10.1
34 acute laryngitis 10.1
35 pulmonary emphysema 10.1
36 al amyloidosis 10.1
37 amyloidosis aa 10.1
38 thymoma, familial 10.1
39 thymoma 10.1

Graphical network of the top 20 diseases related to Tracheopathia Osteoplastica:



Diseases related to Tracheopathia Osteoplastica

Symptoms & Phenotypes for Tracheopathia Osteoplastica

Human phenotypes related to Tracheopathia Osteoplastica:

58 31 (show all 26)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 productive cough 58 31 hallmark (90%) Very frequent (99-80%) HP:0031245
2 tracheal calcification 58 31 hallmark (90%) Very frequent (99-80%) HP:0002787
3 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
4 calcification of cartilage 58 31 frequent (33%) Frequent (79-30%) HP:0100593
5 tracheal stenosis 58 31 frequent (33%) Frequent (79-30%) HP:0002777
6 upper airway obstruction 58 31 frequent (33%) Frequent (79-30%) HP:0002781
7 exertional dyspnea 58 31 frequent (33%) Frequent (79-30%) HP:0002875
8 bronchitis 58 31 frequent (33%) Frequent (79-30%) HP:0012387
9 abnormal bronchus morphology 58 31 frequent (33%) Frequent (79-30%) HP:0025426
10 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
11 hoarse voice 58 31 occasional (7.5%) Occasional (29-5%) HP:0001609
12 chest pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0100749
13 recurrent pneumonia 58 31 occasional (7.5%) Occasional (29-5%) HP:0006532
14 stridor 58 31 occasional (7.5%) Occasional (29-5%) HP:0010307
15 esophagitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100633
16 wheezing 58 31 occasional (7.5%) Occasional (29-5%) HP:0030828
17 chest tightness 58 31 occasional (7.5%) Occasional (29-5%) HP:0031352
18 respiratory insufficiency 58 31 very rare (1%) Very rare (<4-1%) HP:0002093
19 atelectasis 58 31 very rare (1%) Very rare (<4-1%) HP:0100750
20 recurrent respiratory infections 58 Frequent (79-30%)
21 abnormality of the skeletal system 31 HP:0000924
22 dyspnea 31 HP:0002094
23 cough 31 HP:0012735
24 abnormal tracheobronchial morphology 58 Frequent (79-30%)
25 pneumonia 58 Frequent (79-30%)
26 abnormal sputum 58 Frequent (79-30%)

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Resp:
dyspnea
hemoptysis
recurrent pneumonia
wheezing
coughing
more
Radiology:
beaded calcification of tracheobronchial cartilages by ct

Clinical features from OMIM®:

189961 (Updated 05-Apr-2021)

Drugs & Therapeutics for Tracheopathia Osteoplastica

Search Clinical Trials , NIH Clinical Center for Tracheopathia Osteoplastica

Genetic Tests for Tracheopathia Osteoplastica

Anatomical Context for Tracheopathia Osteoplastica

MalaCards organs/tissues related to Tracheopathia Osteoplastica:

40
Trachea, Lung, Heart, Liver, Skin

Publications for Tracheopathia Osteoplastica

Articles related to Tracheopathia Osteoplastica:

(show top 50) (show all 251)
# Title Authors PMID Year
1
Tracheopathia osteoplastica: familial occurrence. 61 57
2509829 1989
2
Tracheopathia osteoplastica misdiagnosed as asthma. 54 61
17530521 2007
3
Tracheobronchopathia osteochondroplastica. 54 61
16088609 2002
4
Surgical Management in Tracheobronchopathia Osteochondroplastica: A Case Study. 61
33001442 2021
5
Multi-nodule of large airway: tracheobronchopathia osteochondroplastica. 61
33183038 2021
6
Intubation Technique in a Patient with Tracheobronchopathia Osteochondroplastica. 61
33460424 2021
7
Tracheobronchopathia Osteochondroplastica: Five Cases Report and Literature Review. 61
32339049 2020
8
Study and reflection on anesthesia for tracheobronchopathia osteochondroplastica. 61
33233977 2020
9
Tracheobronchopathia Osteochondroplastica: A Case Report. 61
33124932 2020
10
Clinical course of tracheobronchopathia osteochondroplastica. 61
33209390 2020
11
Tracheobronchopathia osteochondroplastica: rare but not to be forgotten. 61
32607244 2020
12
Rare Manifestation of Idiopathic Tracheobronchopathia Osteochondroplastica: Misdiagnosed and Untreated Entity? 61
32864236 2020
13
Bronchoscopic Surgery for a Solitary Tracheal Tumor of Tracheobronchopathia Osteochondroplastica. 61
31606516 2020
14
Tracheobronchopathia osteochondroplastica. 61
31014555 2020
15
Difficult intubation in an asymptomatic patient with tracheobronchopathia osteochondroplastica. 61
32025306 2020
16
Tracheobronchopathia osteochondroplastica: A case report and literature review. 61
32386050 2020
17
Tracheobronchopathia Osteochondroplastica-Clinical, Radiological, and Endoscopic Correlation: Case Series and Literature Review. 61
32406259 2020
18
Clinical Characteristics of Six Cases of Tracheobronchopathia Osteochondroplastica. 61
32612728 2020
19
Tracheobronchopathia Osteochondroplastica: Two Different Facets of a Rare Entity. 61
33194870 2020
20
Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA). 61
32695571 2020
21
Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA). 61
32995262 2020
22
Bronchoscopy for Chronic Unexplained Cough: Use of Biopsies and Cultures Increase Diagnostic Yield. 61
31651543 2020
23
[Open Heart Surgery Using an Endotracheal Tube Introducer in a Patient with Tracheobronchopathia Osteochondroplastica;Report of a Case]. 61
31879388 2019
24
Tracheobronchopathia osteochondroplastica : a rare cause of hemoptysis. 61
32173834 2019
25
Costoclavicular block for shoulder surgery in a patient with tracheobronchopathia osteochondroplastica and COPD. 61
30584975 2019
26
Tracheobronchopathia osteochondroplastica: a rare tracheal lesion in a free-ranging grizzly bear. 61
31006353 2019
27
Tracheobronchopathia Osteochondroplastica. 61
31171132 2019
28
[Tracheobronchopathia osteochondroplastica: a clinicopathological analysis of 18 cases]. 61
30955267 2019
29
Tracheobronchopathia Osteochondroplastica: End Stage of Tracheo-Bronchial Amyloidosis? 61
32411269 2019
30
Clinical Characteristics of Tracheobronchopathia Osteochondroplastica. 61
30181364 2019
31
Tracheobronchopathia Osteochondroplastica: A Case Report Illustrating the Importance of Multilevel Workup Clinical, Endoscopic and Histological Assessment in Diagnosis of an Uncommon Disease. 61
30655500 2019
32
Coexistence of Tracheobronchopathia Osteochondroplastica and Sarcoidosis: Accidental Finding or Something More? 61
30562285 2019
33
[Clinicpathologic studies of cases with tracheobronchopathia osteochondroplastica]. 61
30423610 2018
34
Does Adenovirus and Coxsackie B Virus Infection Play a Role in Tracheobronchopathia Osteochondroplastica (TO). 61
30549982 2018
35
Tracheobronchopathia Osteochondroplastica. 61
29519749 2018
36
Tracheobronchopathia Osteochondroplastica. A Chance Finding. 61
29122335 2018
37
Tracheobronchopathia Osteochondroplastica: A Cause of Difficult Tracheal Intubation. 61
29093416 2018
38
Tracheobronchopathia Osteochondroplastica as a Single Mass in Lingular Bronchus. 61
29362199 2018
39
[The progress of tracheobronchopathia osteochondroplastica]. 61
29320836 2017
40
Tracheobronchopathia osteochondroplastica following laryngeal tuberculosis. 61
28869241 2017
41
Tracheobronchopathia osteochondroplastica in recurrent retrosternal goiter. Surgical management. 61
28904244 2017
42
Tracheobronchopathia osteochondroplastica: awareness is the key for diagnosis and management. 61
28784888 2017
43
Multinodule abnormalities of the tracheobronchus: bronchoscopy findings and clinical diagnosis. 61
26260022 2017
44
Coincident Tuberculosis and Tracheobronchopathia Osteochondroplastica in a Patient. 61
28073584 2017
45
Large airways nodularity secondary to tracheobronchopathia osteochondroplastica. 61
27682329 2017
46
Tracheobronchopathia osteochondroplastica. 61
28538784 2017
47
Nephroquiz 9: Tracheobronchopathia Osteochondroplastica Presenting With Dyspnea in a Patient With End-stage Renal Disease. 61
28174357 2017
48
Tracheobronchopathia osteochondroplastica - a 61-year-old female with middle lobe syndrome. 61
28667658 2017
49
Autofluorescence imaging bronchoscopy as a novel approach to the management of tracheobronchopathia osteochondroplastica: a case report. 61
27867586 2016
50
[Silicosis with tracheobronchopathia osteochondroplastica: one case report]. 61
27866552 2016

Variations for Tracheopathia Osteoplastica

Expression for Tracheopathia Osteoplastica

Search GEO for disease gene expression data for Tracheopathia Osteoplastica.

Pathways for Tracheopathia Osteoplastica

GO Terms for Tracheopathia Osteoplastica

Sources for Tracheopathia Osteoplastica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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