MCID: TRC008
MIFTS: 53

Trachoma

Categories: Eye diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Trachoma

MalaCards integrated aliases for Trachoma:

Name: Trachoma 12 74 52 54 43 15 71 32
Trachoma, Initial Stage 71
Trachoma, Active Stage 71
Active Stage Trachoma 12
Trachoma Dubium 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11265
MeSH 43 D014141
UMLS 71 C0040592 C0153107 C0153108

Summaries for Trachoma

Disease Ontology : 12 A commensal bacterial infectious disease that results in infection located in eye, has material basis in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted by contact with eye discharge from the infected person and transmitted by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea.

MalaCards based summary : Trachoma, also known as trachoma, initial stage, is related to chlamydia and conjunctivitis. An important gene associated with Trachoma is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Trimethoprim and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 74 Trachoma is an infectious disease caused by bacterium Chlamydia trachomatis. The infection causes a... more...

Related Diseases for Trachoma

Diseases related to Trachoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 552)
# Related Disease Score Top Affiliating Genes
1 chlamydia 31.6 TNF MBL2 IL6 IL4 IL17A IL10
2 conjunctivitis 31.2 TNF IL6 IL4 IL10 FOXP3
3 chronic conjunctivitis 30.7 TNF IL6 IL4 IL10
4 keratoconjunctivitis 30.7 TNF IL6 IL4 IL17A
5 urethritis 30.6 TNF IL6 HSPD1
6 plague 30.6 TNF IL6 IL10
7 poliomyelitis 30.6 TNF IL4 IL10
8 keratitis, hereditary 30.5 VEGFA TNF IL6 IL17A IL10
9 filariasis 30.4 VEGFA TNF IL6 IL10
10 endophthalmitis 30.4 VEGFA TNF IL6
11 rosacea 30.4 VEGFA TNF IL6
12 dry eye syndrome 30.3 TNF IL6 EGF
13 erythema multiforme 30.3 TNF IL6 IL4
14 eye disease 30.3 VEGFA TNF IL6 IL4 IL17A IL10
15 dacryoadenitis 30.2 TGFB1 IL17A IL10 FOXP3
16 proteasome-associated autoinflammatory syndrome 1 30.2 TNF IL6 IL4 IL17A IL10
17 ocular cicatricial pemphigoid 30.2 TGFB1 IL4 CCN2
18 schistosomiasis 30.2 TNF TGFB1 IL4 IL17A IL10
19 retinal detachment 30.2 VEGFA TNF IL6 CCN2
20 leptospirosis 30.1 TNF IL6 IL4 IL10
21 conjunctival disease 30.1 TNF IL6 IL4 IL17A IL10
22 cholera 30.1 TNF IL6 IL4 EGF
23 allergic hypersensitivity disease 29.9 TNF IL4 IL17A IL10 FOXP3
24 allergic conjunctivitis 29.9 TNF IL4 IL10 FOXP3
25 chlamydia pneumonia 29.9 TNF IL6 IL10 HSPD1
26 q fever 29.8 TNF MBL2 IL6 IL4 IL10
27 urinary schistosomiasis 29.8 STH IL4 HP
28 corneal disease 29.7 VEGFA TNF IL6 IL10 EGF
29 bacterial infectious disease 29.7 TNF MBL2 IL6 IL17A IL10 HSPD1
30 diarrhea 29.6 TNF TGFB1 MPG IL6 IL10 FOXP3
31 filarial elephantiasis 29.6 STH MPG IL4 IL10
32 rhinitis 29.4 TNF IL6 IL4 IL17A IL10 FOXP3
33 dracunculiasis 29.3 STH MPG
34 dermatitis, atopic 29.3 TNF IL6 IL4 IL17A IL10 FOXP3
35 leprosy 3 29.3 TNF IL6 IL4 IL17A IL10 HSPD1
36 skin disease 29.3 TNF IL6 IL4 IL17A IL10 FOXP3
37 uveitis 29.3 TNF IL6 IL4 IL17A IL10 HSPD1
38 reactive arthritis 29.2 TNF IL6 IL17A IL10 HSPD1 HP
39 parasitic helminthiasis infectious disease 28.7 TNF STH IL6 IL4 IL17A IL10
40 malaria 26.5 VEGFA TNF TGFB1 MBL2 IL6 IL4
41 onchocerciasis 11.7
42 entropion 11.6
43 yemenite deaf-blind hypopigmentation syndrome 11.1
44 inclusion conjunctivitis 10.7
45 ornithosis 10.7
46 punctate inner choroidopathy 10.6 TNF IL10
47 external pathological resorption 10.6 TNF IL6
48 scorpion envenomation 10.6 TNF IL6
49 multifocal choroiditis 10.5 TNF IL10
50 lymphogranuloma venereum 10.5

Graphical network of the top 20 diseases related to Trachoma:



Diseases related to Trachoma

Symptoms & Phenotypes for Trachoma

MGI Mouse Phenotypes related to Trachoma:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.38 CCN2 FOXP3 HP HSPD1 IDO1 IL10
2 homeostasis/metabolism MP:0005376 10.37 CCN2 ENG FOXP3 HP IDO1 IL10
3 hematopoietic system MP:0005397 10.36 ENG FOXP3 HP IDO1 IL10 IL17A
4 cardiovascular system MP:0005385 10.32 CCN2 ENG FOXP3 HP IDO1 IL10
5 immune system MP:0005387 10.32 EGF FOXP3 HP IDO1 IL10 IL17A
6 growth/size/body region MP:0005378 10.3 CCN2 EGF ENG FOXP3 HSPD1 IL10
7 digestive/alimentary MP:0005381 10.29 CCN2 EGF ENG FOXP3 IL10 IL17A
8 endocrine/exocrine gland MP:0005379 10.28 CCN2 EGF FOXP3 IL10 IL17A IL4
9 craniofacial MP:0005382 10.21 CCN2 ENG FOXP3 IL10 IL17A IL4
10 integument MP:0010771 10.2 CCN2 EGF ENG FOXP3 IL10 IL17A
11 liver/biliary system MP:0005370 10.09 CCN2 FOXP3 HP IL10 IL4 IL6
12 muscle MP:0005369 10.01 ENG HSPD1 IDO1 IL10 IL6 TGFB1
13 renal/urinary system MP:0005367 9.97 FOXP3 HP IDO1 IL17A IL4 IL6
14 reproductive system MP:0005389 9.96 EGF FOXP3 HSPD1 IDO1 IL10 IL4
15 neoplasm MP:0002006 9.91 HP IL10 IL6 MPG TGFB1 TNF
16 respiratory system MP:0005388 9.9 CCN2 ENG FOXP3 IL10 IL17A IL4
17 skeleton MP:0005390 9.65 CCN2 IL10 IL17A IL4 IL6 LTB4R
18 vision/eye MP:0005391 9.28 CCN2 EGF FOXP3 IL10 IL4 IL6

Drugs & Therapeutics for Trachoma

Drugs for Trachoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
3
Sulfamethoxazole Approved Phase 4 723-46-6 5329
4
tannic acid Approved Phase 4 1401-55-4
5
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
6
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
7
Fluorometholone Approved, Investigational Phase 4 426-13-1 9878
8 Renal Agents Phase 4
9 Anti-Infective Agents, Urinary Phase 4
10 Antimalarials Phase 4
11 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
12 Anti-Bacterial Agents Phase 4
13 Pharmaceutical Solutions Phase 4
14 Ophthalmic Solutions Phase 4
15 Antitubercular Agents Phase 4
16 Antibiotics, Antitubercular Phase 4
17 Lubricant Eye Drops Phase 4
18 Hormone Antagonists Phase 4
19 Anti-Inflammatory Agents Phase 4
20 glucocorticoids Phase 4
21 Hormones Phase 4
22 Anti-Allergic Agents Phase 4
23
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 3 90-89-1 3052
24
Lumefantrine Approved Phase 3 82186-77-4 6437380
25
Artesunate Approved, Investigational Phase 3 88495-63-0 6917864 5464098
26
Artemether Approved Phase 3 71963-77-4 119380 68911
27 Artemether, Lumefantrine Drug Combination Phase 3
28 Antiviral Agents Phase 3
29
Iodine Approved, Investigational Phase 2 7553-56-2 807
30
Povidone Approved Phase 2 9003-39-8
31
Povidone-iodine Approved Phase 2 25655-41-8
32
Permethrin Approved, Investigational Phase 2 52645-53-1 40326
33 Micronutrients Phase 2
34 Trace Elements Phase 2
35 Plasma Substitutes Phase 2
36 Nutrients Phase 2
37 cadexomer iodine Phase 2
38 Blood Substitutes Phase 2
39 Anti-Infective Agents, Local Phase 2
40 Insect Repellents Phase 2
41 Protective Agents Phase 2
42 Vaccines Phase 1
43 Immunologic Factors Phase 1
44
Formaldehyde Approved, Vet_approved 50-00-0 712
45 Immunoglobulin A

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 Strategies for the Control of Blinding Trachoma: Effect of Fly Spray Completed NCT00347763 Phase 4
2 Cost-effectiveness of Three Alternative Azithromycin Treatment Strategies for Trachoma Control in Tanzania Completed NCT00347607 Phase 4
3 Trachoma Elimination With Repeated Mass Azithromycin Treatments Completed NCT00221364 Phase 4 Mass treatment with oral azithromycin to an entire village
4 Research to Programs for Trachoma Elimination: Antibiotic Trial Completed NCT00792922 Phase 4 Azithromycin;Azithromycin
5 Eliminating Trachoma With Repeat Mass Drug Treatment Completed NCT00322972 Phase 4 Mass treatment with oral azithromycin to an entire community
6 Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger Completed NCT00618449 Phase 4 Azithromcyin;Azithromycin
7 Determination of the Impact of Water and Health Education on Trachoma and Ocular C. Trachomatis in Niger Completed NCT00348478 Phase 4
8 Tripartite International Research for the Elimination of Trachoma Completed NCT01202331 Phase 4 mass treatment with oral azithromycin
9 Trial of Antibiotics to Reduce Recurrent Trichiasis (STAR) Completed NCT00347776 Phase 4 azithromycin;topical tetracycline
10 A Randomised Controlled Trial of Non-absorbable (Silk) Sutures Verses Absorbable (Vicryl) Sutures During the Surgical Treatment of Trachomatous Trichiasis Completed NCT00522860 Phase 4
11 Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso Completed NCT03187834 Phase 4 Azithromycin;Amoxicillin;Cotrimoxazole;Placebo
12 Community Health Azithromycin Trial in Burkina Faso Recruiting NCT03676764 Phase 4 Azithromycin;Placebos
13 Neonates and Azithromycin, an Innovation in the Treatment of Children in Burkina Faso Recruiting NCT03682653 Phase 4 Azithromycin;Placebo
14 Azithromycin to Prevent Post-discharge Morbidity and Mortality in Kenyan Children Recruiting NCT02414399 Phase 4 Azithromycin;Placebo
15 Gut and Azithromycin Mechanisms in Infants and Neonates Recruiting NCT03676751 Phase 4 Azithromycin;Placebo
16 Evaluating Impact of Azithromycin Mass Drug Administrations on All-cause Mortality and Antibiotic Resistance: Morbidity Study Enrolling by invitation NCT02048007 Phase 4 Azithromycin;Placebo
17 Kebele Elimination of Trachoma for Ocular Health Not yet recruiting NCT03335072 Phase 4 Azithromycin
18 Trachoma Elimination Study by Focused Antibiotic (TESFA): The Impact of an Enhanced Antibiotic Treatment Regimen on Trachoma in Amhara, Ethiopia Not yet recruiting NCT03523156 Phase 4 Azithromycin mass treatment;Azithromycin targeted treatment
19 Azithromycin Reduction to Reach Elimination of Trachoma Not yet recruiting NCT04185402 Phase 4 Azithromycin
20 Safety of the Co-administration of Azithromycin, Albendazole and Ivermectin Versus Standard Treatment Regimens During Mass Drug Administration (MDA) in Ethiopia: a Cluster-randomized Trial Not yet recruiting NCT03570814 Phase 4 Administration of Albendazole on Day 1;Administration of Ivermectin on Day 1;Administration of Azithromycin on Day 1;Administration of Azithromycin on Day 15
21 FLuorometholone as Adjunctive MEdical Therapy for TT Surgery (FLAME) Trial Not yet recruiting NCT04149210 Phase 4 Fluorometholone 0.1% Oph Susp;Artificial Tears
22 AZIVAL 2: A Double-blind Cluster-randomized Placebo-controlled Study on the Safety of Integrated Treatment of Trachoma and Lymphatic Filariasis in Children and Adults With Azithromycin, Ivermectin and Albendazole Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
23 Azithromycin in Control of Trachoma II Withdrawn NCT00286026 Phase 4 Azithromycin
24 Clinical Efficacy and Safety of 2 Dosing Regimens of T1225 Eye Drops 1.5% (Instilled Twice Daily for 2 or 3 Days) Versus Oral Azithromycin in Treatment of Trachoma Completed NCT00356720 Phase 3 Azithromycin
25 A Cluster Randomised Trial of the Safety of Co-Administration of IDA (Ivermectin, Diethylcarbamazine and Albendazole) & Azithromycin for Integrated Treatment of Neglected Tropical Diseases Completed NCT03676140 Phase 3 Albendazole on Day 1;Ivermectin on Day 1;Diethylcarbamazine on day 1;Azithromycin on Day 1;Azithromycin on Day 8
26 A Randomized Trial of Azithromycin + Artesunate v Artemether-lumefantrine in Uncomplicated Malaria in Tanzanian Children. Completed NCT00694694 Phase 3 azithromycin + artesunate;artemether-lumefantrine
27 Sanitation, Water, and Instruction in Face-washing for Trachoma I/II Recruiting NCT02754583 Phase 3 Azithromycin;Tetracycline;Albendazole
28 Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis and Death: a Phase III Double-blind Randomized Clinical Trial Recruiting NCT03199547 Phase 3 Azithromycin;Placebo Oral Tablet
29 Nepal Elimination of Trachoma Study Withdrawn NCT02176057 Phase 2, Phase 3 Azithromycin
30 A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers Completed NCT00386958 Phase 2 Povidone-Iodine
31 A Within-subject Laboratory and Field Trial to Test the Use of Commercially Available Insect Repellents Against Contact From Musca Sorbens, the Putative Vector of Trachoma Suspended NCT03813069 Phase 2
32 A Phase I, Double-blind, Parallel, Randomised and Placebo-controlled Trial Investigating the Safety and Immunogenicity of a Chlamydia Vaccine, CTH522, in Healthy Adults Not yet recruiting NCT03926728 Phase 1
33 Water Uptake for Health in Amhara Pilot Completed NCT02373657
34 A Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation: The ASANTE Trial Completed NCT01767506
35 A Pharmacovigilance Study on the Safety of Integrated Treatment of Trachoma and Lymphatic Filariasis in Children and Adults Living in the Sikasso Region of Mali Completed NCT01586169 triple co administration at once of the combination of Albendazole + ivermectin + azithromycin
36 Partnership for the Rapid Elimination of Trachoma (PRET) Clinical Trial of Evaluation of Modified Instrumentation for Surgery to Correct Trichiasis Completed NCT00886015
37 Identification of TT Cases by Community Treatment Assistants: An Assessment Completed NCT01783743
38 A Randomised Controlled Trial of Epilation Verses Immediate Surgery for the Management of Minor Trachomatous Trichiasis Completed NCT00522912
39 The Effect of Oral Azithromycin in the Treatment of Chlamydial Conjunctivitis Completed NCT01178762 Azithromycin
40 Fluorometholone 0.1% as Perioperative Adjunct Therapy for Lid-rotation Surgery in Trachomatous Entropion and Trichiasis, Dose-varying Study Completed NCT01949454 Fluorometholone 0.1% ophthalmic solution
41 The Effect of Long-Term HEAD START Training on Surgical Skill Levels Completed NCT03135080
42 Comparison of Ultrasonic Pachymetry With Orbscan in Corneal Haze Completed NCT00439114
43 The Effect of Hydrodynamic Parameters on Corneal Endothelial Cell Loss After Phacoemulsification Completed NCT00370955
44 Developing and Evaluating Trachoma Diagnosis Training Tools in Preparation for the Trachoma Elimination Endgame: Development of a Smartphone Application to Capture Quality Images of Everted Eye Lids and Assessment of Its Acceptability and Feasibility Recruiting NCT03997487
45 Developing and Evaluating Trachoma Diagnosis Training Tools in Preparation for the Trachoma Elimination Endgame: Investigating the Effectiveness, Acceptability and Feasibility of an App-based Versus Slide-based IGA Test for Trachoma Graders Recruiting NCT04002726
46 Histologic Evaluation Comparing Power Settings in Radiofrequency Ablation on Eyelash Follicles Not yet recruiting NCT03947723
47 Évaluation de l'Utilisation d'un Photoscreener Comme méthode de dépistage Des problèmes Ophtalmologiques pédiatriques en Haïti Withdrawn NCT02655432

Search NIH Clinical Center for Trachoma

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Sulfacetamide
Sulfacetamide Sodium
Sulfisoxazole Diolamine

Cochrane evidence based reviews: trachoma

Genetic Tests for Trachoma

Anatomical Context for Trachoma

The Foundational Model of Anatomy Ontology organs/tissues related to Trachoma:

19
Eye

MalaCards organs/tissues related to Trachoma:

40
Eye, Testes, T Cells, B Cells, Bone, Heart, Lung

Publications for Trachoma

Articles related to Trachoma:

(show top 50) (show all 3943)
# Title Authors PMID Year
1
Airflow limitation, asthma, and Chlamydia pneumoniae-specific heat shock protein 60. 54 61
19119705 2008
2
Multiple Chlamydiaceae species in trachoma: implications for disease pathogenesis and control. 54 61
18177205 2008
3
Chlamydia pneumoniae as a respiratory pathogen. 54 61
11861211 2002
4
Immune response to chlamydial 60-kilodalton heat shock protein in tears from Nepali trachoma patients. 54 61
11447178 2001
5
Persistent Chlamydia trachomatis infections resist apoptotic stimuli. 54 61
11254605 2001
6
Characterization of B-cell responses to Chlamydia trachomatis antigens in humans with trachoma. 54 61
9393782 1997
7
Ocular Chlamydia trachomatis infection, anti-Pgp3 antibodies and conjunctival scarring in Vanuatu and Tarawa, Kiribati before antibiotic treatment for trachoma. 61
32017971 2020
8
The rise or fall of neglected tropical diseases in East Asia Pacific. 61
31550453 2020
9
Milestones in the fight to eliminate trachoma. 61
32017172 2020
10
The immuno-pathogenesis of progressive scarring trachoma: results of a four-year longitudinal study in Tanzanian children. 61
31964744 2020
11
Trachoma: Time to Talk Eradication. 61
31864470 2020
12
Herbert Pits in Trachoma Infection. 61
31902408 2020
13
Prevalence of Trachoma in Pakistan: Results of 42 Population-Based Prevalence Surveys from the Global Trachoma Mapping Project. 61
31916887 2020
14
Trachoma, anti-Pgp3 serology and ocular Chlamydia trachomatis infection in Papua New Guinea. 61
31965155 2020
15
Anti-chlamydial activities of cell-permeable hydrophobic dipeptide-containing derivatives. 61
31230920 2019
16
One Size Does Not Fit All: Achieving Trachoma Control by 2030. 61
31595872 2019
17
Progress to Eliminate Trachoma as a Public Health Problem in Amhara National Regional State, Ethiopia: Results of 152 Population-Based Surveys. 61
31549612 2019
18
Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial. 61
31796025 2019
19
Posterior lamellar versus bilamellar tarsal rotation surgery for trachomatous trichiasis: Long-term outcomes from a randomised controlled trial. 61
31891136 2019
20
Chlamydia trachomatis serovars in urogenital and ocular samples collected 2014-2017 from Austrian patients. 61
31798000 2019
21
Coverage assessment survey following trachoma mass drug administration (MDA) in six districts of Oromia, Western Ethiopia, 2017. 61
31841516 2019
22
Progress toward Elimination of Trachoma as a Public Health Problem in Seven Localities in the Republic of Sudan: Results from Population-Based Surveys. 61
31595874 2019
23
Prevalence and associated factors of active trachoma among children in Ethiopia: a systematic review and meta-analysis. 61
31864307 2019
24
Evidence for contamination with C. trachomatis in the household environment of children with active Trachoma: A cross-sectional study in Kongwa, Tanzania. 61
31869324 2019
25
A Review of the Literature on the Global Epidemiology of Corneal Blindness. 61
31433359 2019
26
Gender-related factors affecting health seeking for neglected tropical diseases: findings from a qualitative study in Ethiopia. 61
31830026 2019
27
Impact of mass drug administration of azithromycin for trachoma elimination on prevalence and azithromycin resistance of genital Mycoplasma genitalium infection. 61
30981999 2019
28
Household Survey of Trachoma among Children Living in Pernambuco, Brazil. 61
31775360 2019
29
Smartphone photography as a possible method of post-validation trachoma surveillance in resource-limited settings. 61
31329890 2019
30
Evaluation for learning and improvement at the right time: an example from the field. 61
31760754 2019
31
Whole-genome sequencing of ocular Chlamydia trachomatis isolates from Gadarif State, Sudan. 61
31685017 2019
32
The global burden of trichiasis in 2016. 61
31765415 2019
33
Perceptions and practices of community members relating to trachoma in Africa: a qualitative systematic review protocol. 61
31290788 2019
34
Associations between Water, Sanitation and Hygiene (WASH) and trachoma clustering at aggregate spatial scales, Amhara, Ethiopia. 61
31727155 2019
35
Chlamydiae from Down Under: The Curious Cases of Chlamydial Infections in Australia. 61
31766703 2019
36
Status of vaccine research and development of vaccines for Chlamydia trachomatis infection. 61
28111145 2019
37
Chlamydia trachomatis: when the virulence-associated genome backbone imports a prevalence-associated major antigen signature. 61
31697227 2019
38
Pgp3 seroprevalence and associations with active trachoma and ocular Chlamydia trachomatis infection in Malawi: cross-sectional surveys in six evaluation units. 61
31658258 2019
39
Impact of a single round of mass drug administration with azithromycin on active trachoma and ocular Chlamydia trachomatis prevalence and circulating strains in The Gambia and Senegal. 61
31640755 2019
40
Unimproved water sources and open defecation are associated with active trachoma in children in internally displaced persons camps in the Darfur States of Sudan. 61
31612959 2019
41
Antimicrobial Resistance Following Azithromycin Mass Drug Administration: Potential Surveillance Strategies to Assess Public Health Impact. 61
31633161 2019
42
Pre-operative trichiatic eyelash pattern predicts post-operative trachomatous trichiasis. 61
31589610 2019
43
Selecting behaviour change priorities for trachoma 'F' and 'E' interventions: A formative research study in Oromia, Ethiopia. 61
31596851 2019
44
Integrating Face Washing into a School-Based, Handwashing Behavior Change Program to Prevent Trachoma in Turkana, Kenya. 61
31392952 2019
45
Prevalence of active trachoma and associated factors among children aged 1 to 9 years in rural communities of Lemo district, southern Ethiopia: community based cross sectional study. 61
31651236 2019
46
Adults visual impairment and blindness - An overview of prevalence and causes in Saudi Arabia. 61
31920448 2019
47
Whatever happened to China's neglected tropical diseases? 61
31578156 2019
48
Neglected tropical diseases in the People's Republic of China: progress towards elimination. 61
31578147 2019
49
Estimating the intracluster correlation coefficient for trachomatous inflammation-follicular in population-based trachoma prevalence surveys: results from a meta-regression of 261 standardised pre-intervention surveys in Ethiopia, Mozambique, and Nigeria. 61
31509177 2019
50
BioStruct-Africa: empowering Africa-based scientists through structural biology knowledge transfer and mentoring - recent advances and future perspectives. 61
31490179 2019

Variations for Trachoma

Expression for Trachoma

Search GEO for disease gene expression data for Trachoma.

Pathways for Trachoma

Pathways related to Trachoma according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 VEGFA TNF TGFB1 MBL2 IL6 IL4
2
Show member pathways
13.83 VEGFA TNF TGFB1 IL6 IL4 IL17A
3
Show member pathways
13.55 VEGFA TNF TGFB1 IL6 IL4 IL17A
4
Show member pathways
13.42 TNF TGFB1 IL6 IL4 IL17A IL10
5
Show member pathways
13.36 VEGFA TNF TGFB1 IL6 IL4 IL17A
6
Show member pathways
13.31 TNF TGFB1 IL6 IL4 IL17A IL10
7
Show member pathways
13.13 TNF TGFB1 MBL2 IL6 IL10 EGF
8 12.84 VEGFA TGFB1 IL6 IL4 EGF
9
Show member pathways
12.72 VEGFA TNF TGFB1 IL6 IL4 IL17A
10
Show member pathways
12.71 TNF TGFB1 IL6 EGF CCN2
11 12.59 TNF IL4 IL17A IL10 IDO1 FOXP3
12
Show member pathways
12.58 TNF TGFB1 IL6 IL4 IL17A IL10
13
Show member pathways
12.56 TNF TGFB1 IL6 IL4 IL17A IL10
14
Show member pathways
12.35 IL6 IL4 IL10 EGF
15
Show member pathways
12.34 TNF IL6 IL4 IL17A
16
Show member pathways
12.33 TNF IL6 IL4 HBB
17
Show member pathways
12.27 TNF TGFB1 IL4 IL10
18 12.27 TNF TGFB1 IL6 IL10 HSPD1
19 12.25 TGFB1 FOXP3 ENG CCN2
20 12.23 VEGFA TNF TGFB1 IL6 EGF
21 12.21 VEGFA TNF IL6 IL10 HSPD1
22
Show member pathways
12.21 TNF TGFB1 IL6 IL4 IL17A IL10
23
Show member pathways
12.11 TGFB1 IL6 IL10 EGF
24 12.09 VEGFA TGFB1 IL6 EGF
25
Show member pathways
12.07 TNF TGFB1 IL6 IL17A IL10
26
Show member pathways
12.06 TNF IL6 IL4 HSPD1
27 12.02 TNF TGFB1 LTB4R IL6 IL4
28 12 TNF IL6 IL4 IL10 ENG
29 11.96 TNF TGFB1 IL6 IL10
30 11.94 VEGFA TNF TGFB1 IL6
31
Show member pathways
11.9 TGFB1 IL6 IL17A FOXP3
32 11.88 VEGFA TNF TGFB1 IL6 IL17A
33 11.83 TNF IL4 IL17A IL10
34 11.79 TNF TGFB1 IL6 IL10
35 11.77 TNF IL6 IL10
36
Show member pathways
11.77 TNF IL4 FOXP3
37
Show member pathways
11.67 VEGFA TNF IL6
38 11.66 TNF TGFB1 ENG EGF
39 11.62 TNF IL6 HSPD1
40 11.58 TNF IL6 IL4 IL10
41 11.57 VEGFA TGFB1 IL6
42 11.56 VEGFA TGFB1 IL6 EGF
43 11.55 TNF IL6 HP CCN2
44 11.52 IL4 IL10 FOXP3
45 11.51 TGFB1 IL10 HSPD1
46 11.5 TNF TGFB1 IL6 IL10 HBB
47 11.48 TNF TGFB1 IL6 IL4 IL17A IL10
48 11.38 TNF IL6 IL10
49 11.33 TNF IL6 IL4 IL17A
50 11.33 TNF IL6 IL10 IDO1 HBB

GO Terms for Trachoma

Cellular components related to Trachoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 VEGFA TNF TGFB1 MBL2 IL6 IL4
2 extracellular matrix GO:0031012 9.67 VEGFA TGFB1 MBL2 CCN2
3 cell surface GO:0009986 9.63 VEGFA TNF TGFB1 MBL2 HSPD1 ENG
4 extracellular space GO:0005615 9.47 VEGFA TNF TGFB1 MBL2 IL6 IL4
5 platelet alpha granule lumen GO:0031093 9.43 VEGFA TGFB1 EGF
6 haptoglobin-hemoglobin complex GO:0031838 9.32 HP HBB

Biological processes related to Trachoma according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 10.04 TNF TGFB1 IL6 IDO1 HSPD1
2 immune response GO:0006955 10.03 TNF LTB4R IL6 IL4 IL17A IL10
3 positive regulation of transcription, DNA-templated GO:0045893 10.02 TNF TGFB1 IL6 IL4 IL10 FOXP3
4 positive regulation of transcription by RNA polymerase II GO:0045944 10.02 VEGFA TNF TGFB1 IL6 IL4 IL17A
5 defense response to bacterium GO:0042742 9.99 TNF MBL2 IL10 HP
6 angiogenesis GO:0001525 9.99 VEGFA ENG EGF CCN2
7 positive regulation of protein kinase B signaling GO:0051897 9.96 TNF TGFB1 ENG EGF
8 response to glucocorticoid GO:0051384 9.85 TNF IL6 IL10
9 vasculogenesis GO:0001570 9.85 VEGFA TGFB1 ENG
10 positive regulation of protein phosphorylation GO:0001934 9.85 VEGFA TNF TGFB1 ENG CCN2
11 positive regulation of interleukin-6 production GO:0032755 9.84 TNF IL6 HSPD1
12 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.84 VEGFA TGFB1 IL6 EGF
13 positive regulation of cell death GO:0010942 9.83 HP HBB CCN2
14 negative regulation of fat cell differentiation GO:0045599 9.83 TNF TGFB1 IL6
15 response to organic substance GO:0010033 9.83 TNF TGFB1 IL10 HP
16 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.81 VEGFA TNF TGFB1 IL6
17 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.8 VEGFA TNF IL6 IL4
18 negative regulation of gene expression GO:0010629 9.8 VEGFA TNF TGFB1 FOXP3 ENG CCN2
19 positive regulation of protein complex assembly GO:0031334 9.79 VEGFA TNF TGFB1
20 negative regulation of mitotic cell cycle GO:0045930 9.78 TNF TGFB1 IL10
21 acute-phase response GO:0006953 9.77 MBL2 IL6 HP
22 negative regulation of interleukin-6 production GO:0032715 9.77 TNF IL10 FOXP3
23 positive regulation of JAK-STAT cascade GO:0046427 9.74 TNF IL6 IL10
24 positive regulation of MAP kinase activity GO:0043406 9.73 VEGFA TNF TGFB1 EGF
25 positive regulation of collagen biosynthetic process GO:0032967 9.72 TGFB1 ENG CCN2
26 T cell activation GO:0042110 9.71 TGFB1 IL4 HSPD1 FOXP3
27 positive regulation of neuroinflammatory response GO:0150078 9.7 TNF IL6
28 negative regulation of activated T cell proliferation GO:0046007 9.7 IDO1 FOXP3
29 positive regulation of regulatory T cell differentiation GO:0045591 9.7 TGFB1 FOXP3
30 inflammatory response GO:0006954 9.7 TNF TGFB1 LTB4R IL6 IL17A IL10
31 positive regulation of vascular permeability GO:0043117 9.69 VEGFA TGFB1
32 positive regulation of MHC class II biosynthetic process GO:0045348 9.68 IL4 IL10
33 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.68 IL4 IL10
34 negative regulation of lipid storage GO:0010888 9.68 TNF IL6
35 endothelial cell apoptotic process GO:0072577 9.67 TNF IL10
36 negative regulation of cytokine secretion involved in immune response GO:0002740 9.66 TNF IL10
37 positive regulation of mononuclear cell migration GO:0071677 9.64 TNF TGFB1
38 connective tissue development GO:0061448 9.64 TGFB1 CCN2
39 type 2 immune response GO:0042092 9.63 IL4 IL10
40 positive regulation of T cell tolerance induction GO:0002666 9.63 IDO1 FOXP3
41 extracellular matrix constituent secretion GO:0070278 9.62 ENG CCN2
42 regulation of isotype switching GO:0045191 9.62 IL4 IL10
43 receptor biosynthetic process GO:0032800 9.58 TNF IL10
44 tolerance induction to self antigen GO:0002513 9.58 TGFB1 FOXP3
45 negative regulation of T cell proliferation GO:0042130 9.56 TGFB1 IL10 IDO1 FOXP3
46 cytokine-mediated signaling pathway GO:0019221 9.5 VEGFA TNF TGFB1 IL6 IL4 IL17A
47 positive regulation of gene expression GO:0010628 9.28 VEGFA TNF TGFB1 IL6 IL4 FOXP3

Molecular functions related to Trachoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.25 VEGFA TNF TGFB1 STH MPG MBL2
2 cytokine activity GO:0005125 9.5 VEGFA TNF TGFB1 IL6 IL4 IL17A
3 type I transforming growth factor beta receptor binding GO:0034713 9.37 TGFB1 ENG
4 type II transforming growth factor beta receptor binding GO:0005114 9.26 TGFB1 ENG
5 growth factor activity GO:0008083 9.17 VEGFA TGFB1 IL6 IL4 IL10 EGF
6 hemoglobin binding GO:0030492 9.16 HP HBB

Sources for Trachoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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