Transient Arthritis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Transient Arthritis

MalaCards integrated aliases for Transient Arthritis:

Name: Transient Arthritis ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Anatomical: Bone diseases Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the musculoskeletal system and connective tissue

Inflammatory polyarthropathies

Other specific arthropathies

Other specific arthropathies, not elsewhere classified

External Ids:

Disease Ontology ¹² DOID:2092

ICD10 ³³ M12.8

ICD9CM ³⁵ 716.4 716.40

NCIt ⁵⁰ C35761

SNOMED-CT ⁶⁸ 66191007

UMLS ⁷³ C0152083 C3887596

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Summaries for Transient Arthritis

MalaCards based summary : Transient Arthritis is related to arthritis and tenosynovitis. An important gene associated with Transient Arthritis is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Tuberculosis. Affiliated tissues include skin, bone and lung, and related phenotypes are Reduced mammosphere formation and cellular

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Related Diseases for Transient Arthritis

Diseases in the Arthritis family:

Transient Arthritis

Diseases related to Transient Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)

#	Related Disease	Score	Top Affiliating Genes
1	arthritis	29.8	ACAN IL1A IL6 TGFB1 TNFRSF1B
2	tenosynovitis	29.6	COMP MRAP TNFRSF1B
3	palindromic rheumatism	29.3	MRAP PRTN3 TNFRSF10A TNFRSF1B
4	rheumatoid arthritis	28.8	COMP IL1A IL6 PRTN3 TGFB1 TNFRSF1B
5	balanitis	10.2	MRAP PHB2
6	bone chondrosarcoma	10.2	ACAN COMP
7	geniculate herpes zoster	10.2	SERPINA1 TNFRSF10A
8	pyuria	10.2	ALB MRAP
9	enthesopathy	10.2	MRAP PHB2
10	tendinitis	10.2	COMP MRAP PHB2
11	cartilage disease	10.2	ACAN COMP TNFRSF10A
12	meningovascular neurosyphilis	10.2	ALB MBP
13	gastritis, familial giant hypertrophic	10.2	ALB SERPINA1
14	scleral disease	10.2	MRAP TNFRSF1B
15	pustulosis of palm and sole	10.2	MRAP TNFRSF1B
16	bursitis	10.2	MRAP PHB2
17	constrictive pericarditis	10.1	ALB SERPINA1
18	urethritis	10.1	MRAP PHB2
19	hepatic tuberculosis	10.1	ALB SERPINA1
20	diabetic foot ulcers	10.1	IL6 TGFB1
21	iritis	10.1	MRAP PHB2 TNFRSF1B
22	orbital plasma cell granuloma	10.1	MRAP TNFRSF1B
23	chondromalacia	10.1	COMP TNFRSF10A TNFRSF1B
24	dysentery	10.1	ALB IL1A PHB2
25	chronic graft versus host disease	10.1	ALB IL1A
26	leukoregulin	10.1	IL1A TGFB1
27	posterior scleritis	10.1	MRAP PRTN3 TNFRSF10A
28	keratoconjunctivitis sicca	10.1	ALB IL1A IL6
29	uveal disease	10.1	IL6 MRAP TNFRSF1B
30	rhinoscleroma	10.1	SERPINA1 TNFRSF1B
31	proteasome-associated autoinflammatory syndrome 1	10.1	ALB IL1A IL6
32	fournier gangrene	10.1	ALB F3
33	laryngitis	10.1	IL6 TGFB1
34	kidney hypertrophy	10.1	ALB TGFB1
35	meningoencephalitis	10.1	ALB IL6 MBP
36	aortic valve disease 1	10.1	ACAN MRAP TGFB1
37	carpal tunnel syndrome	10.0	ACAN IL6 TGFB1
38	primary bacterial infectious disease	10.0	ALB IL6 TNFRSF1B
39	gastrointestinal system disease	10.0	ALB IL6 SERPINA1
40	peripheral nervous system disease	10.0	ALB IL6 MBP
41	nervous system disease	10.0	ALB IL6 MBP
42	gingival disease	10.0	IL1A IL6 TGFB1
43	idiopathic neutropenia	10.0	IL1A IL6 TGFB1
44	anca-associated vasculitis	10.0	IL6 PRTN3 SERPINA1
45	gingival overgrowth	10.0	IL1A IL6 TGFB1
46	chronic orbital inflammation	10.0	MRAP PRTN3 TNFRSF1B
47	anterior scleritis	10.0	MRAP PRTN3 TNFRSF1B
48	granulomatous myositis	10.0	PRTN3 TNFRSF1B
49	iga glomerulonephritis	10.0	ALB IL6 TGFB1
50	end stage renal failure	10.0	ALB IL6 TGFB1

Graphical network of the top 20 diseases related to Transient Arthritis:

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Symptoms & Phenotypes for Transient Arthritis

GenomeRNAi Phenotypes related to Transient Arthritis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.1	ALB CLEC7A PHB2 PRTN3 TGFB1 TNFRSF1B

MGI Mouse Phenotypes related to Transient Arthritis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.96	ALB COMP F3 IL6 MBP PHB2
2	hematopoietic system	MP:0005397	9.81	CLEC7A F3 IL1A IL6 MBP PRTN3
3	immune system	MP:0005387	9.65	CLEC7A COMP F3 IL1A IL6 MBP
4	neoplasm	MP:0002006	9.17	ALB F3 IL1A IL6 TGFB1 TNFRSF10A

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Drugs & Therapeutics for Transient Arthritis

Search Clinical Trials , NIH Clinical Center for Transient Arthritis

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Genetic Tests for Transient Arthritis

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Anatomical Context for Transient Arthritis

MalaCards organs/tissues related to Transient Arthritis:

⁴¹

Skin, Bone, Lung, Brain, Kidney, Liver, Spinal Cord

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Publications for Transient Arthritis

Articles related to Transient Arthritis:

#	Title	Authors	Year
1	Activated partial thromboplastin time sensitivity to lupus anticoagulant in a patient with transient arthritis and lupus anticoagulant-hypoprothrombinemia syndrome. ( 25380995 )	Mauge L....Darnige L.	2014
2	Rapid release of high mobility group box protein-1 (HMGB-1) in transient arthritis. ( 20483058 )	de Grauw J.C....Konttinen Y.T.	2010
3	Induction of transient arthritis by the adoptive transfer of a collagen II specific Th1 clone to HLA-DR4 (B1*0401) transgenic mice. ( 12367557 )	Wang D....Bell D.A.	2002
4	Transient arthritis with positive tests for rheumatoid factor as presenting sign of shunt nephritis. ( 2015013 )		1991
5	Tenosynovitis and transient arthritis associated with Haemophilus influenzae type b bacteremia. ( 3261417 )	Mustafa M.M....McCracken G.H.	1988
6	Demonstration and characterization of a transient arthritis in rats following sensitization of synovial mast cells with antigen-specific IgE and parenteral challenge with specific antigen. ( 2457375 )		1988
7	Transient arthritis of the hip in children (a study of 74 cases). ( 6469611 )	Vidigal E.C.	1984
8	Transient arthritis after rubella vaccination. ( 5794817 )	Cooper L.Z....Krugman S.	1969
9	Acute transient arthritis of the adult hip. Its relation to rheumatoid arthritis and to &quot;palindromic rheumatism&quot;. ( 14462616 )	LASS R....Shephard E.	1962

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Genes for Transient Arthritis

Genes related to Transient Arthritis (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	15.7	DISEASES inferred ¹⁵
2	CLEC7A	C-Type Lectin Domain Containing 7A	Protein Coding	14.74	DISEASES inferred ¹⁵
3	COMP	Cartilage Oligomeric Matrix Protein	Protein Coding	14.38	DISEASES inferred ¹⁵
4	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	14.29	DISEASES inferred ¹⁵
5	PHB2	Prohibitin 2	Protein Coding	14.13	DISEASES inferred ¹⁵
6	ACAN	Aggrecan	Protein Coding	13.99	DISEASES inferred ¹⁵
7	IL6	Interleukin 6	Protein Coding	13.46	DISEASES inferred ¹⁵
8	IL1A	Interleukin 1 Alpha	Protein Coding	13.41	DISEASES inferred ¹⁵
9	ALB	Albumin	Protein Coding	13.4	DISEASES inferred ¹⁵
10	SERPINA1	Serpin Family A Member 1	Protein Coding	13.25	DISEASES inferred ¹⁵
11	MBP	Myelin Basic Protein	Protein Coding	13.24	DISEASES inferred ¹⁵
12	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	13.04	DISEASES inferred ¹⁵
13	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	13.01	DISEASES inferred ¹⁵
14	F3	Coagulation Factor III, Tissue Factor	Protein Coding	12.98	DISEASES inferred ¹⁵
15	ERVW-1	Endogenous Retrovirus Group W Member 1, Envelope	Protein Coding	3.93	DISEASES inferred ¹⁵
16	PRTN3	Proteinase 3	Protein Coding	3.44	DISEASES inferred ¹⁵

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Variations for Transient Arthritis

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Expression for Transient Arthritis

Search GEO for disease gene expression data for Transient Arthritis.

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Pathways for Transient Arthritis

Pathways related to Transient Arthritis according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	13.09	ALB F3 PRTN3 SERPINA1 TGFB1 TNFRSF10A
2	Tuberculosis ³⁷	12.01	CLEC7A IL1A IL6 TGFB1
3	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.78	IL1A IL6 TGFB1 TNFRSF10A TNFRSF1B
4	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.75	ALB IL6 SERPINA1 TGFB1
5	Senescence and Autophagy in Cancer ¹	11.73	IL1A IL6 TGFB1
6	Rheumatoid arthritis ³⁷	11.64	IL1A IL6 TGFB1
7	Interleukin-4 and 13 signaling ⁶⁶	11.51	IL1A IL6 TGFB1 TNFRSF1B
8	Lung fibrosis ¹	11.47	IL6 SERPINA1 TGFB1
9	ECM proteoglycans ⁶⁶	11.41	ACAN COMP TGFB1
10	Interleukin-10 signaling ⁶⁶	11.3	IL1A IL6 TNFRSF1B
11	Malaria ³⁷	11.27	COMP IL6 TGFB1
12	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.25	F3 IL1A IL6 TGFB1
13	Spinal Cord Injury ¹	11.1	ACAN IL1A IL6 MBP TGFB1
14	Cytokines and Inflammatory Response ¹	10.9	IL1A IL6 TGFB1

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GO Terms for Transient Arthritis

Cellular components related to Transient Arthritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.76	ALB COMP F3 IL1A IL6 PRTN3
2	cell surface	GO:0009986	9.72	F3 MBP PHB2 TGFB1 TNFRSF10A
3	extracellular region	GO:0005576	9.65	ACAN ALB COMP F3 IL1A IL6
4	platelet alpha granule lumen	GO:0031093	9.43	ALB SERPINA1 TGFB1
5	collagen-containing extracellular matrix	GO:0062023	9.1	ACAN COMP F3 PRTN3 SERPINA1 TGFB1

Biological processes related to Transient Arthritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	platelet degranulation	GO:0002576	9.65	ALB SERPINA1 TGFB1
2	negative regulation of protein localization to plasma membrane	GO:1903077	9.46	MRAP TGFB1
3	negative regulation of phagocytosis	GO:0050765	9.43	PRTN3 TGFB1
4	connective tissue replacement involved in inflammatory response wound healing	GO:0002248	9.4	IL1A TGFB1
5	mammary gland branching involved in thelarche	GO:0060744	9.37	PHB2 TGFB1
6	inflammatory response	GO:0006954	9.35	CLEC7A IL1A IL6 TGFB1 TNFRSF1B
7	extrinsic apoptotic signaling pathway	GO:0097191	9.33	TGFB1 TNFRSF10A TNFRSF1B
8	positive regulation of exit from mitosis	GO:0031536	9.32	PHB2 TGFB1
9	regulation of branching involved in mammary gland duct morphogenesis	GO:0060762	9.26	PHB2 TGFB1
10	cytokine-mediated signaling pathway	GO:0019221	9.1	F3 IL1A IL6 PRTN3 TGFB1 TNFRSF1B

Molecular functions related to Transient Arthritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.83	ACAN ALB CLEC7A COMP F3 IL1A
2	protease binding	GO:0002020	9.02	COMP F3 MBP SERPINA1 TNFRSF10A

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