Transient Cerebral Ischemia (TIA)

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Transient Cerebral Ischemia

MalaCards integrated aliases for Transient Cerebral Ischemia:

Name: Transient Cerebral Ischemia 12 54 15 71
Transient Ischemic Attack 12 53 54 6 42 17 71
Transient Ischemic Attacks 12 15
Tia - Transient Ischaemic Attack 12
Transient Cerebral Ischaemia 12
Ischemic Attack, Transient 43
Tia 12


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Disease Ontology 12 DOID:224
MeSH 43 D002546
NCIt 49 C50781
SNOMED-CT 67 38609002
ICD10 32 G45.9
UMLS 71 C0007787 C0917805

Summaries for Transient Cerebral Ischemia

MedlinePlus : 42 A transient ischemic attack (TIA) is a stroke that lasts only a few minutes. It happens when the blood supply to part of the brain is briefly blocked. Symptoms of a TIA are like other stroke symptoms, but do not last as long. They happen suddenly, and include Numbness or weakness, especially on one side of the body Confusion or trouble speaking or understanding speech Trouble seeing in one or both eyes Difficulty walking Dizziness Loss of balance or coordination Most symptoms of a TIA disappear within an hour, although they may last for up to 24 hours. Because you cannot tell if these symptoms are from a TIA or a stroke, you should go to the hospital right away. TIAs are often a warning sign for future strokes. Taking medicine, such as blood thinners, may reduce your risk of a stroke. Your doctor might also recommend surgery. You can also help lower your risk by having a healthy lifestyle. This includes not smoking, not drinking too much, eating a healthy diet, and exercising. It is also important to control other health problems, such as high blood pressure and cholesterol. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Transient Cerebral Ischemia, also known as transient ischemic attack, is related to ischemia and peripheral nervous system disease, and has symptoms including seizures, tremor and angina pectoris. An important gene associated with Transient Cerebral Ischemia is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways are Measles and Neuroscience. The drugs Aspirin and Irbesartan have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and kidney, and related phenotypes are homeostasis/metabolism and nervous system

Disease Ontology : 12 A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death.

NINDS : 53 A transient ischemic attack (TIA) is a transient stroke that lasts only a few minutes. It occurs when the blood supply to part of the brain is briefly interrupted. TIA symptoms, which usually occur suddenly, are similar to those of stroke but do not last as long. Most symptoms of a TIA disappear within an hour, although they may persist for up to 24 hours. Symptoms can include: numbness or weakness in the face, arm, or leg, especially on one side of the body; confusion or difficulty in talking or understanding speech; trouble seeing in one or both eyes; and difficulty with walking, dizziness, or loss of balance and coordination.

Wikipedia : 74 A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by loss of blood... more...

Related Diseases for Transient Cerebral Ischemia

Diseases related to Transient Cerebral Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 485)
# Related Disease Score Top Affiliating Genes
1 ischemia 31.4 MAP2 HSPA4 HSPA1A CASP3
2 peripheral nervous system disease 30.7 IL1B CCL2 CASP3 ACHE
3 cytomegalovirus infection 30.5 IL1B CCL2 CASP3
4 agraphia 30.1 MAPT ACHE
5 carotid artery occlusion 30.1 MAP2 HSPA1A CASP3 APOH
6 encephalomalacia 30.0 MTHFR IL1B CASP3
7 binswanger's disease 30.0 NOTCH3 MAPT ACHE
8 spinal cord infarction 29.7 MTHFR APOH
9 retinal artery occlusion 29.5 MTHFR CCL2 APOH
10 homocysteinemia 29.5 MTHFR CCL2 APOH
11 vascular disease 29.5 MTHFR HSPA4 CCL2 CASP3 APOH
12 intracranial hypertension 29.4 MTHFR IL1B APOH
13 dementia 29.4 NOTCH3 MAPT MAP2 HSPA4 ACHE
14 placenta disease 29.4 MTHFR IL1B APOH
15 migraine with or without aura 1 29.1 NOTCH3 MTHFR IL1B DRD1 APOH
16 vascular dementia 29.1 NOTCH3 MTHFR MAPT IL1B GRIN2A CASP3
17 cerebrovascular disease 28.7 NOTCH3 MTHFR MAPT APOH ACHE
18 stroke, ischemic 27.9 NOTCH3 MTHFR MAPT MAP2 HSPA4 CASP3
19 mini stroke 11.9
20 paresthesia 11.7
21 pulmonary arteriovenous fistulas 11.7
22 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 11.7
23 essential thrombocythemia 11.7
24 moyamoya disease 1 11.7
25 carotid artery disease 11.7
26 sneddon syndrome 11.5
27 moyamoya disease 2 11.5
28 moyamoya disease 6 with or without achalasia 11.5
29 buerger disease 11.4
30 telangiectasia, hereditary hemorrhagic, type 4 11.4
31 moyamoya disease 5 11.4
32 aganglionosis, total intestinal 11.3
33 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 11.2
34 cerebral artery occlusion 10.8
35 palladium allergic contact dermatitis 10.5 IL1B CCL2
36 atrial fibrillation 10.5
37 congenital cytomegalovirus 10.4 IL1B CCL2
38 yellow fever 10.4 IL1B CCL2 CASP3
39 brain edema 10.4
40 pneumoconiosis 10.4 IL1B CCL2 CASP3
41 neuritis 10.3 MAPT IL1B CCL2
42 stachybotrys chartarum 10.3 IL1B CCL2
43 leishmaniasis 10.3 ODC1 IL1B HSPA4 CCL2
44 disease of mental health 10.3 MAPT GRIN2A DRD1 ACHE
45 vertebrobasilar insufficiency 10.3
46 thrombocytosis 10.3
47 sleep apnea 10.3
48 obsessive-compulsive disorder 10.3 SLC1A1 IL1B GRIN2A DRD1
49 ataxia and polyneuropathy, adult-onset 10.3
50 papilledema 10.3

Comorbidity relations with Transient Cerebral Ischemia via Phenotypic Disease Network (PDN): (show top 50) (show all 86)

Active Peptic Ulcer Disease Acute Cystitis
Acute Myocardial Infarction Alzheimer Disease
Anxiety Aortic Atherosclerosis
Aortic Valve Disease 1 Atrioventricular Block
Basilar Artery Insufficiency Benign Essential Hypertension
Bronchitis Bronchopneumonia
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Chronic Maxillary Sinusitis
Communicating Hydrocephalus Conjunctivitis
Conversion Disorder Cystitis
Decubitus Ulcer Deficiency Anemia
Diabetic Polyneuropathy Dysthymic Disorder
Encephalopathy Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Facial Paralysis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Gout
Heart Disease Hyperlipoproteinemia, Type Iv
Hypertension, Essential Hypertensive Encephalopathy
Hypoglycemia Hypoglycemic Coma
Hypothyroidism Inner Ear Disease
Intermediate Coronary Syndrome Intracranial Embolism
Intracranial Thrombosis Iron Deficiency Anemia
Kidney Disease Labyrinthitis
Left Bundle Branch Hemiblock Macular Degeneration, Age-Related, 1
Major Depressive Disorder Malignant Essential Hypertension

Graphical network of the top 20 diseases related to Transient Cerebral Ischemia:

Diseases related to Transient Cerebral Ischemia

Symptoms & Phenotypes for Transient Cerebral Ischemia

UMLS symptoms related to Transient Cerebral Ischemia:

seizures, tremor, angina pectoris, edema, chest pain, back pain, amaurosis fugax, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness, transient ischemic attacks, differing symptoms, transient ischemic attacks, stereotypic symptoms

MGI Mouse Phenotypes related to Transient Cerebral Ischemia:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.77 ACHE APOH BAD CASP3 DRD1 IL1B
2 nervous system MP:0003631 9.4 ACHE BAD CASP3 DRD1 GRIN2A HSPA4

Drugs & Therapeutics for Transient Cerebral Ischemia

Drugs for Transient Cerebral Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 322)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
Acenocoumarol Approved, Investigational Phase 4 152-72-7 9052 54676537
Sodium citrate Approved, Investigational Phase 4 68-04-2
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
Varenicline Approved, Investigational Phase 4 249296-44-4 5310966
Nicotine Approved Phase 4 54-11-5 942 89594
Bupropion Approved Phase 4 34911-55-2, 34841-39-9 444
Metformin Approved Phase 4 657-24-9 14219 4091
Amlodipine Approved Phase 4 88150-42-9 2162
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
Tranexamic Acid Approved Phase 4 1197-18-8 5526
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
Simvastatin Approved Phase 4 79902-63-9 54454
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
Losartan Approved Phase 4 114798-26-4 3961
Pravastatin Approved Phase 4 81093-37-0 54687
Atorvastatin Approved Phase 4 134523-00-5 60823
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
Ethanol Approved Phase 4 64-17-5 702
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
Candesartan Experimental Phase 4 139481-59-7 2541
Dabigatran Investigational Phase 4 211914-51-1
36 Platelet Aggregation Inhibitors Phase 4
37 Antirheumatic Agents Phase 4
38 Prasugrel hydrochloride Phase 4 389574-19-0
39 Vardenafil Dihydrochloride Phase 4
40 Sildenafil Citrate Phase 4 171599-83-0
41 Citrate Phase 4
42 Phosphodiesterase 5 Inhibitors Phase 4
43 Radiation-Protective Agents Phase 4
44 Vitamins Phase 4
45 Trace Elements Phase 4
46 Vitamin B Complex Phase 4
47 Vitamin B9 Phase 4
48 Nutrients Phase 4
49 Folate Phase 4
50 Micronutrients Phase 4

Interventional clinical trials:

(show top 50) (show all 478)
# Name Status NCT ID Phase Drugs
1 The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial Unknown status NCT00724724 Phase 4 Butylphthalide Soft Capsules;Aspirin
2 The Middle East Dual Anti-platelet Treatment in Acute Transient Ischemic Attack.10 vs 30 Days of Combination ASA and Clopidogrel Study Unknown status NCT02144831 Phase 4 anti-thrombotic treatment using Aspirin (ASA 75-325mg) and Clopidogrel (75mg)
3 A Prospective, Multicenter, Randomized, Open-label Trial to Evaluate Efficacy and Safety of 5mg Maintenance Dose of Prasugrel in Patients With Acute Coronary Syndrome Who Underwent Percutaneous Coronary Intervention With BiomatrixTM Stent Unknown status NCT02446730 Phase 4 Prasugel;Clopidogrel
4 The Impact of Intensive Rosuvastatin Therapy on Cerebral Hemodynamics in Patients With Atherosclerotic Intracranial Arterial Stenosis Evaluated by Computed Tomography Perfusion (CTP) Unknown status NCT02594800 Phase 4 Rosuvastatin
5 Rule Out Transcatheter Aortic Valve Thrombosis With Post Implantation Computed Tomography Unknown status NCT02826200 Phase 4 Acenocoumarol
6 A Prospective, Randomized, 3-arm Parallel Trial to Evaluate the Safety and Clinical Effectiveness of 2 Lower Dose Combined PDE5i's vs. Single Maximal Dose PDE5i Treatment Unknown status NCT00498680 Phase 4 Sildenafil, Vardenafil;Sildenafil;Vardenafil;Sildenafil & Vardenafil
7 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients (ALEVENT) Unknown status NCT01503671 Phase 4 Atorvastatin
8 Renoprotection by Combining Pentoxifylline and Angiotensin Blockade in Chronic Kidney Disease Unknown status NCT01377285 Phase 4 ARB;Pentoxifylline;Placebo (for Pentoxifylline)
9 Does Discontinuation of Aspirin Treatment Following Head Trauma Decrease the Incidence of Chronic Subdural Hematoma? Unknown status NCT01470040 Phase 4 discontinuation of aspirin therapy;continuation of aspirin therapy
10 CRYptogenic STroke And underLying AF Trial Completed NCT00924638 Phase 4
11 ESPRIT: European/Australasian Stroke Prevention in Reversible Ischaemia Trial Completed NCT00161070 Phase 4 anticoagulation;aspirin and dipyridamole;aspirin alone
12 A Double-Blind, Randomized, Placebo- Controlled Study Of Atorvastatin As Prevention Of Cerebrovascular Events In Patients With A Previous Transient Ischemic Attack (TIA) Or Stroke Completed NCT00147602 Phase 4 atorvastatin
13 Preventing Recurrent Vascular Events and Neurological Worsening Through Intensive Organized Case-Management (PREVENTION) Trial Completed NCT00931788 Phase 4 Antihypertensive agents and lipid lowering therapy
14 Efficacy and Cost-effectiveness of Cost-free Pharmacotherapy for Smoking Cessation for High-risk Smokers With Cerebrovascular Disease Completed NCT00962988 Phase 4 Cost-Free Pharmacotherapy Group
15 The Effect of Dipyridamole on the Pharmacokinetics of Metformin Completed NCT01613755 Phase 4 Metformin, dipyridamole;Metformin
16 A Trial of Telmisartan Prevention of Cardiovascular Disease Completed NCT01075698 Phase 4 Non-ARB (standard therapy);ARB (Telmisartan)
17 Combination of OLMesartan and Calcium Channel Blocker or Low Dose Diuretics in High Risk Elderly Hypertensive Patients Study (COLM-Study) Completed NCT00454662 Phase 4 olmesartan medoxomil / amlodipine or azelnidipine;olmesartan medoxomil / low dose thiazide type drug
18 The Ischemia Management With Accupril Post Bypass Graft Via Inhibition of the coNverting Enzyme (IMAGINE) Trial Completed NCT00269243 Phase 4 Quinapril
19 A Controlled Randomized Trial of Circumferential Pulmonary Vein Ablation Versus Antiarrhythmic Drug Therapy in Treating Paroxysmal Atrial Fibrillation. The Ablation for Paroxysmal Atrial Fibrillation (APAF2) Trial Completed NCT00340314 Phase 4 Antiarrhythmic Drug Therapy
20 Determining the Optimal Dose of Tranexamic Acid in Decreasing Blood Loss During Lower Extremity Total Joint Arthroplasty Completed NCT02584725 Phase 4 Tranexamic Acid
21 Post Marketing Surveillance Study for LDL Apheresis Using H.E.L.P. Therapy Completed NCT00916643 Phase 4
22 Efficacy of Different Perioperative Statin Regimens on the Protection Against Post Coronary Artery Bypass Grafting Major Adverse Cardio-cerebral Events Completed NCT02706860 Phase 4 Atorvastatin
23 Multiple Intervention and AUdit in Renal Diseases to Optimize Care: the MAURO Study. Completed NCT00566033 Phase 4
24 A Comparison of Isolating the Pulmonary Veins With the Cryoballoon Catheter Versus Radiofrequency Segmental Isolation:a Randomized Controlled Prospective Non-inferiority Trial Completed NCT00774566 Phase 4
25 Magnetic Resonance Characterization of Carotid Atherosclerotic Plaque in Vivo: Effect of High Density Lipoprotein Elevation on Plaque Morphology Completed NCT00307307 Phase 4 Niacin/simvastatin compared to simvastatin alone at 2 doses
26 Evaluation of Late Clinical Events After Drug-eluting Versus Bare-metal Stents in Patients at Risk: BAsel Stent Kosten Effektivitäts Trial - PROspective Validation Examination Part II (BASKET-PROVE II) Completed NCT01166685 Phase 4
27 Efficacy of Two Different Doses of Atorvastatin for Prevention of Periprocedural Ischemic Brain Damage in Chinese Patients Undergoing Carotid Artery Stenting (CAS) Recruiting NCT03079115 Phase 4 High-dose Atorvastatin;Conventional-dose Atorvastatin
28 Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD Recruiting NCT03417388 Phase 4 High dose potent statin;ACE-I (lisinopril) or ARB (losartan);Aspirin
29 European Society of Hypertension and Chinese Hypertension League Stroke in Hypertension Optimal Treatment Trial Recruiting NCT01563731 Phase 4 all approved antihypertensive drugs; all approved statins
30 Beta-blockeRs tO patieNts With CHronIc Obstructive puLmonary diseasE Recruiting NCT03566667 Phase 4 Metoprolol;Standard care
31 Influenza Vaccination After Myocardial Infarction (IAMI Trial): A Multicenter, Prospective, Randomized Controlled Clinical Trial Based on the Swedish Angiography and Angioplasty Registry (SCAAR) Platform Recruiting NCT02831608 Phase 4
32 Use of Rosuvastatin to Achieve Lipid Targets in African American Subjects With Cerebrovascular Disease Terminated NCT01975194 Phase 4 Rosuvastatin
33 Optimization of Pre-surgical Testing With an Intensive Multifactorial Intervention to MinimiZe Cardiovascular Events in Orthopedic Surgery Terminated NCT01837069 Phase 4 Metoprolol;Lisinopril;Atorvastatin
34 Accelerated Atherosclerosis in High Risk Population Groups: An Assessment by Magnetic Resonance Imaging Terminated NCT02114697 Phase 4 Statin therapy
35 Dabigatran-related Effect on Progression of Atrial Fibrosis in Patients With Atrial Fibrillation Terminated NCT01546883 Phase 4 Dabigatran etexilate (Pradaxa)
36 Thalidomide for the Treatment of Malnutrition Inflammation Syndrome in Peritoneal Dialysis Patients: A Randomized Control Trial Withdrawn NCT00390247 Phase 4 thalidomide
37 A Prospective, Multicenter, Randomized Controlled Trial to Evaluate the Safety and Efficacy of the STARFlex® Septal Closure System Versus Best Medical Therapy in Patients With a Stroke and/or Transient Ischemic Attack Due to Presumed Paradoxical Embolism Through a Patent Foramen Ovale Unknown status NCT00201461 Phase 2, Phase 3 Best medical therapy
38 A Randomized, Open-label, Active-Controlled and Blinded-Endpoint Trial Comparing the Antiplatelet Effects of Ticagrelor Plus Aspirin Versus Clopidogrel Plus Aspirin in Chinese Patients With High-risk Transient Ischemic Attack or Minor Stroke. Unknown status NCT02506140 Phase 2, Phase 3 Ticagrelor and Acetylsalicylic acid;Clopidogrel and Acetylsalicylic acid
39 Treatment of Edoxaban Versus Aspirin for Non-disabling Cerebrovascular Events: Rationale, Objectives, and Design Unknown status NCT02221102 Phase 2, Phase 3 Aspirin;edoxaban;placebo
40 Randomized,Double-blind Trial Comparing the Effects of a Rivaroxaban Regimen During the First 30 Days,Versus Aspirin for the Acute Treatment of TIA or Minor Stroke Unknown status NCT01923818 Phase 2, Phase 3 rivaroxaban;Aspirin;placebo
41 A Prospective, Multicentre, Randomized, Open Label, Blinded Endpoint, Phase 3 Trial to Assess the Safety and Efficacy of Prophylactic TicagrelOr With Acetylsalicylic Acid Versus CLopidogrel With Acetylsalicylic Acid in the Development of Cerebrovascular EMbolic Events During Transcatheter Aortic Valve Implantation (TAVI) OperationS - the PTOLEMAIOS Study. Unknown status NCT02989558 Phase 3 Ticagrelor plus ASA;Clopidogrel plus ASA
42 SAINT (Stroke - Acute Ischemic - NXY Treatment) A Double Blind, Randomized, Placebo Controlled, Parallel Group, Multicenter, Phase IIb/III Study to Assess the Efficacy and Safety of Intravenous NXY-059 in Acute Ischemic Stroke Completed NCT00061022 Phase 3 NXY-059
43 Comprehensive Cardiac Rehabilitation Programming For Patients Following Transient Ischemic Attack Completed NCT00536562 Phase 3
44 Diagnosis and Treatment of Sleep Apnea in Cerebrovascular Disease Completed NCT00984308 Phase 2, Phase 3
45 Carotid Artery Revascularization Using the Boston Scientific EPI Filter Wire EZ™ and the EndoTex™ NexStent™ Completed NCT00600327 Phase 3
46 Prevention of New Vascular Events in Patients With Brain Infarction or Peripheral Embolism and Thoracic Aortic Plaques ≥ 4 mm in Thickness in the Aortic Arch or Descending Aortic Upstream to the Embolized Artery Completed NCT00235248 Phase 3 Warfarin;Clopidogrel-aspirin
47 Apixaban for Early Prevention of Recurrent Embolic Stroke and Hemorrhagic Transformation Completed NCT02283294 Phase 3 Apixaban;Warfarin
48 Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis Completed NCT00190398 Phase 3
49 Fast Assessment of Stroke and Transient Ischemic Attack to Prevent Early Recurrence (FASTER) Completed NCT00109382 Phase 2, Phase 3 Aspirin;Clopidogrel;Simvastatin
50 Randomized,Double-blind Trial Comparing the Effects of a 3-month Clopidogrel Regimen,Combined With ASA During the First 21days,Versus ASA Alone for the Acute Treatment of TIA or Minor Stroke Completed NCT00979589 Phase 3 Clopidogrel;Placebo of clopidogrel and Asprin

Search NIH Clinical Center for Transient Cerebral Ischemia

Cochrane evidence based reviews: ischemic attack, transient

Genetic Tests for Transient Cerebral Ischemia

Anatomical Context for Transient Cerebral Ischemia

MalaCards organs/tissues related to Transient Cerebral Ischemia:

Brain, Heart, Kidney, Testes, Eye, Endothelial, Spinal Cord

Publications for Transient Cerebral Ischemia

Articles related to Transient Cerebral Ischemia:

(show top 50) (show all 9247)
# Title Authors PMID Year
Predictors of prolonged hospital stay in a Comprehensive Stroke Unit. 61 42
31618390 2019
Impaired heart rate recovery as a predictor for poor health-related quality in patients with transient ischemic attack. 61 42
31441885 2019
Effects of CHADS2 score, echocardiographic and haematologic parameters on stroke severity and prognosis in patients with stroke due to nonvalvular atrial fibrillation. 42
31517456 2019
Ischemia-related changes in naive and mutant forms of ubiquitin and neuroprotective effects of ubiquitin in the hippocampus following experimental transient ischemic damage. 54 61
19666022 2009
Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention? 54 61
18410505 2008
Postischemic alterations of BDNF, NGF, HSP 70 and ubiquitin immunoreactivity in the gerbil hippocampus: pharmacological approach. 54 61
16810563 2007
Transient cerebral ischemia induces delayed proapoptotic Bad translocation to mitochondria in CA1 sector of hippocampus. 54 61
15710244 2005
Anticardiolipin antibodies and risk of ischemic stroke and transient ischemic attack: the Framingham cohort and offspring study. 54 61
14764933 2004
Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia. 54 61
14580322 2003
Differential expression of HSC73 and HSP72 mRNA and proteins between young and adult gerbils after transient cerebral ischemia: relation to neuronal vulnerability. 54 61
10908039 2000
Leukocyte activation: relation to cardiovascular mortality after cerebrovascular ischemia. 54 61
10686447 2000
Immunoelectron microscopic study of c-Fos, c-Jun and heat shock protein after transient cerebral ischemia in gerbils. 54 61
9930891 1999
Increasing levels of leukocyte-derived inflammatory mediators in plasma and cAMP in platelets during follow-up after acute cerebral ischemia. 54 61
9774747 1998
677C to T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and plasma homocyst(e)ine levels in patients with TIA or minor stroke. 54 61
9562260 1998
Leukocyte activation detected by increased plasma levels of inflammatory mediators in patients with ischemic cerebrovascular diseases. 54 61
8841320 1996
Disturbances of calcium homeostasis within the endoplasmic reticulum may contribute to the development of ischemic-cell damage. 54 61
8910877 1996
Induction of c-fos and c-jun gene products and heat shock protein after brief and prolonged cerebral ischemia in gerbils. 54 61
7660411 1995
Blockade of ornithine decarboxylase enzyme protects against ischemic brain damage. 54 61
7929646 1994
Coexpression of c-fos and hsp70 mRNAs in gerbil brain after ischemia: induction threshold, distribution and time course evaluated by in situ hybridization. 54 61
7854054 1994
An immunohistochemical study of parvalbumin containing interneurons in the gerbil hippocampus after cerebral ischemia. 54 61
7838065 1994
Delayed damage of striatal interneurons after cerebral ischemia in the gerbil. 54 61
7970228 1994
Hemostatic markers in acute transient ischemic attacks. 54 61
8303732 1994
[Induction of HSP70 and neuronal damage following transient cerebral ischemia in rats]. 54 61
8239864 1993
Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia. 54 61
8417138 1993
Autoradiographic analysis of dopamine D1 receptors in the gerbil brain following transient cerebral ischemia. 54 61
1487117 1992
Calcium/calmodulin dependent protein kinase II mRNA in the gerbil brain after cerebral ischemia. 54 61
1331917 1992
Activity of ornithine decarboxylase and S-adenosylmethionine decarboxylase in transient cerebral ischemia: relationship to the duration of vascular occlusion. 54 61
1499693 1992
Hyperglycemia suppresses c-fos mRNA expression following transient cerebral ischemia in gerbils. 54 61
1727138 1992
Postischemic alteration of muscarinic acetylcholine and adenosine A1 binding sites in gerbil brain. Protective effects of a novel vinca alkaloid derivative, vinconate, and pentobarbital using an autoradiographic study. 54 61
1529167 1992
Mild hypothermia ameliorates ubiquitin synthesis and prevents delayed neuronal death in the gerbil hippocampus. 54 61
1660190 1991
Postischemic alteration of muscarinic acetylcholine, adenosine A1 and calcium antagonist binding sites in selectively vulnerable areas: an autoradiographic study of gerbil brain. 54 61
1666408 1991
An immunohistochemical study of MAP2 and clathrin in gerbil hippocampus after cerebral ischemia. 54 61
1722131 1991
Contrast-Enhanced Ultrasound to Assess Carotid Intraplaque Neovascularization. 61
31791553 2020
Feasibility of Atrial Fibrillation Screening With Mobile Health Technologies at Pharmacies. 61
31578088 2020
Early neutrophil-to-lymphocyte ratio is a prognostic marker in acute minor stroke or transient ischemic attack. 61
32036555 2020
A case of growing dural sinus malformation with associated developmental venous anomaly presenting like transient ischemic attack progressing into stroke. 61
32008131 2020
Safety and effectiveness of reduced-dose apixaban in Japanese patients with nonvalvular atrial fibrillation in clinical practice: A sub-analysis of the STANDARD study. 61
31421933 2020
Impact of a Pharmacist-Driven Poststroke Transitions of Care Clinic on 30 and 90-Day Hospital Readmission Rates. 61
32033902 2020
Meta-Analysis Comparing Results of Transcatheter Versus Surgical Aortic-Valve Replacement in Patients With Severe Aortic Stenosis. 61
31780077 2020
Major cardiovascular and bleeding events with long-term use of aspirin in patients with prior cardiovascular diseases: 1-year follow-up results from the Management of Aspirin-induced Gastrointestinal Complications (MAGIC) study. 61
31446462 2020
Impact of the type of electroanatomic mapping system on the incidence of cerebral embolism after radiofrequency catheter ablation of left atrial tachycardias. 61
31518721 2020
Characterization of Carotid Atherosclerotic Plaques Using 3-Dimensional MERGE Magnetic Resonance Imaging and Correlation With Stroke Risk Factors. 61
31902332 2020
Long-term results of polytetrafluoroethylene versus saphenous vein repair of degenerative carotid artery aneurysm. 61
32035773 2020
Higher Long-Term Mortality with Carotid Artery Stenting in Asymptomatic Male Compared to Female Patients in the Southeastern Vascular Study Group. 61
32027990 2020
A case of right internal carotid agenesis with associated transcavernous anastomosis revealed by transient ischemic attack. 61
31535194 2020
Prevalence of Microembolic Signals in Embolic Stroke of Undetermined Source and Other Subtypes of Ischemic Stroke. 61
31771457 2020
Burden of Premature Atrial Complexes and Risk of Recurrent Stroke and Death in Patients with Mild to Moderate Ischemic Stroke. 61
31839547 2020
Factors Associated With 90-Day Readmission After Stroke or Transient Ischemic Attack: Linked Data From the Australian Stroke Clinical Registry. 61
31822248 2020
Epidemiology and clinical characteristics of atrial fibrillation in patients with inherited heart diseases. 61
31930598 2020
Sleep for Stroke Management and Recovery Trial (Sleep SMART): Rationale and methods. 61
32019428 2020

Variations for Transient Cerebral Ischemia

ClinVar genetic disease variations for Transient Cerebral Ischemia:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 NOTCH3 NM_000435.3(NOTCH3):c.457C>T (p.Arg153Cys)SNV Pathogenic 208501 rs797045014 19:15302993-15302993 19:15192182-15192182
2 NOTCH3 NM_000435.3(NOTCH3):c.1450T>G (p.Cys484Gly)SNV Likely pathogenic 523370 rs1555728965 19:15299088-15299088 19:15188277-15188277

Expression for Transient Cerebral Ischemia

Search GEO for disease gene expression data for Transient Cerebral Ischemia.

Pathways for Transient Cerebral Ischemia

Pathways related to Transient Cerebral Ischemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
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5 11.65 IL1B CCL2 CASP3
7 11.42 PTK2B MAPT CASP3
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10 11.3 IL1B HSPA1A CASP3

GO Terms for Transient Cerebral Ischemia

Cellular components related to Transient Cerebral Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.97 PTK2B ODC1 NOTCH3 MTHFR MAPT MAP2
2 cell body GO:0044297 9.5 PTK2B MAPT MAP2
3 nuclear periphery GO:0034399 9.37 MAPT MAP2
4 NMDA selective glutamate receptor complex GO:0017146 9.26 PTK2B GRIN2A
5 main axon GO:0044304 8.96 MAPT MAP2
6 dendritic spine GO:0043197 8.92 PTK2B MAPT GRIN2A DRD1

Biological processes related to Transient Cerebral Ischemia according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.92 IL1B CCL2 CASP3 BAD
2 memory GO:0007613 9.77 MAPT GRIN2A DRD1
3 response to wounding GO:0009611 9.73 GRIN2A CASP3 ACHE
4 response to glucose GO:0009749 9.71 PTK2B CASP3 BAD
5 cellular response to organic cyclic compound GO:0071407 9.7 IL1B CCL2 CASP3
6 response to hydrogen peroxide GO:0042542 9.69 PTK2B CASP3 BAD
7 regulation of synaptic plasticity GO:0048167 9.65 PTK2B MAPT GRIN2A
8 long-term synaptic potentiation GO:0060291 9.63 PTK2B GRIN2A DRD1
9 dopamine metabolic process GO:0042417 9.62 GRIN2A DRD1
10 activation of cysteine-type endopeptidase activity GO:0097202 9.61 GRIN2A BAD
11 central nervous system neuron development GO:0021954 9.61 MAPT MAP2
12 positive regulation of neuron death GO:1901216 9.61 MAPT KMO BAD
13 NAD biosynthetic process GO:0009435 9.6 KYNU KMO
14 regulation of calcium-mediated signaling GO:0050848 9.58 PTK2B MAPT
15 regulation of microtubule polymerization GO:0031113 9.58 MAPT MAP2
16 cellular response to organic substance GO:0071310 9.58 MAP2 IL1B CASP3
17 pyridine nucleotide biosynthetic process GO:0019363 9.57 KYNU KMO
18 tryptophan catabolic process GO:0006569 9.55 KYNU KMO
19 response to amino acid GO:0043200 9.54 MTHFR CASP3 BAD
20 'de novo' NAD biosynthetic process from tryptophan GO:0034354 9.49 KYNU KMO
21 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.33 IL1B CASP3 BAD
22 anthranilate metabolic process GO:0043420 9.32 KYNU KMO
23 quinolinate biosynthetic process GO:0019805 9.26 KYNU KMO
24 positive regulation of synaptic transmission, glutamatergic GO:0051968 9.13 PTK2B DRD1 CCL2
25 response to drug GO:0042493 9.1 PTK2B MTHFR GRIN2A DRD1 CASP3 BAD

Molecular functions related to Transient Cerebral Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NMDA glutamate receptor activity GO:0004972 8.62 PTK2B GRIN2A

Sources for Transient Cerebral Ischemia

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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