MCID: TRN047
MIFTS: 23

Transient Congenital Hypothyroidism

Categories: Endocrine diseases, Immune diseases, Metabolic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Transient Congenital Hypothyroidism

MalaCards integrated aliases for Transient Congenital Hypothyroidism:

Name: Transient Congenital Hypothyroidism 58

Classifications:

Orphanet: 58  
Rare endocrine diseases


External Ids:

Orphanet 58 ORPHA178045

Summaries for Transient Congenital Hypothyroidism

MalaCards based summary : Transient Congenital Hypothyroidism is related to congenital hypothyroidism and hypothyroidism. An important gene associated with Transient Congenital Hypothyroidism is DUOX2 (Dual Oxidase 2), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Amine-derived hormones. Affiliated tissues include thyroid, breast and testes, and related phenotype is hearing/vestibular/ear.

Related Diseases for Transient Congenital Hypothyroidism

Diseases in the Hypothyroidism family:

Congenital Hypothyroidism Central Congenital Hypothyroidism
Hypothyroidism Due to Iodide Transport Defect Rare Adult Hypothyroidism
Transient Congenital Hypothyroidism Rare Hypothyroidism
Primary Congenital Hypothyroidism Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Transient Congenital Hypothyroidism Due to Maternal Factor
Transient Congenital Hypothyroidism Due to Neonatal Factor Congenital Hypothyroidism Due to Transplacental Passage of Tsh-Binding Inhibitory Antibodies
Congenital Hypothyroidism Due to Developmental Anomaly

Diseases related to Transient Congenital Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 congenital hypothyroidism 29.9 TSHR TPO DUOX2
2 hypothyroidism 29.9 TSHR TPO DUOX2
3 permanent congenital hypothyroidism 29.8 TPO DUOX2
4 thyroiditis 29.7 TSHR TPO
5 hashimoto thyroiditis 29.3 TSHR TPO
6 familial thyroid dyshormonogenesis 29.3 TPO DUOX2
7 hyperthyroidism 29.1 TSHR TPO
8 goiter 29.1 TSHR TPO DUOX2
9 hypothyroidism, congenital, nongoitrous, 2 28.7 TSHR TPO DUOX2
10 genetic transient congenital hypothyroidism 12.4
11 transient congenital hypothyroidism due to maternal factor 12.4
12 transient congenital hypothyroidism due to neonatal factor 12.4
13 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 9.9 TSHR DUOX2
14 primary congenital hypothyroidism 9.8
15 athyreosis 9.8
16 hashimoto encephalopathy 9.8 TSHR TPO
17 iodine hypothyroidism 9.8 TSHR TPO
18 thyroid crisis 9.8 TSHR TPO
19 toxic diffuse goiter 9.8 TSHR TPO
20 subacute lymphocytic thyroiditis 9.7 TSHR TPO
21 endemic goiter 9.7 TSHR TPO
22 plummer's disease 9.7 TSHR TPO
23 nontoxic goiter 9.7 TSHR TPO
24 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.7 TSHR TPO
25 graves disease 1 9.7 TSHR TPO
26 myxedema 9.7 TSHR TPO
27 subacute thyroiditis 9.7 TSHR TPO
28 hyperthyroxinemia 9.7 TSHR TPO
29 exophthalmos 9.7 TSHR TPO
30 thyroid gland follicular carcinoma 9.7 TSHR TPO
31 nodular goiter 9.7 TSHR TPO
32 autoimmune disease of endocrine system 9.7 TSHR TPO
33 multinodular goiter 9.7 TSHR TPO
34 differentiated thyroid carcinoma 9.6 TSHR TPO
35 thyroid carcinoma 9.6 TSHR TPO
36 follicular adenoma 9.6 TSHR TPO
37 papillary carcinoma 9.6 TSHR TPO
38 pendred syndrome 9.5 TPO DUOX2
39 thyroid gland anaplastic carcinoma 9.5 TSHR TPO
40 graves' disease 9.4 TSHR TPO
41 thyroid gland disease 9.3 TSHR TPO DUOX2
42 thyroid gland cancer 9.2 TSHR TPO

Graphical network of the top 20 diseases related to Transient Congenital Hypothyroidism:



Diseases related to Transient Congenital Hypothyroidism

Symptoms & Phenotypes for Transient Congenital Hypothyroidism

MGI Mouse Phenotypes related to Transient Congenital Hypothyroidism:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 8.8 DUOX2 TPO TSHR

Drugs & Therapeutics for Transient Congenital Hypothyroidism

Search Clinical Trials , NIH Clinical Center for Transient Congenital Hypothyroidism

Genetic Tests for Transient Congenital Hypothyroidism

Anatomical Context for Transient Congenital Hypothyroidism

MalaCards organs/tissues related to Transient Congenital Hypothyroidism:

40
Thyroid, Breast, Testes

Publications for Transient Congenital Hypothyroidism

Articles related to Transient Congenital Hypothyroidism:

(show top 50) (show all 74)
# Title Authors PMID Year
1
EPIDEMIOLOGIC CHARACTERISTICS AND RISK FACTORS FOR CONGENITAL HYPOTHYROIDISM FROM 2009 TO 2018 IN XIAMEN, CHINA. 61
31968198 2020
2
Changes in nitric oxide synthase levels are associated with impaired cardiac function and tolerance to ischemia-reperfusion injury in male rats with transient congenital hypothyroidism. 61
31940052 2020
3
Audit of the Congenital Hypothyroidism Screening Program in 15 Provinces of Iran. 61
31356097 2019
4
Effects of mandatory salt iodization on breast milk, urinary iodine concentrations, and thyroid hormones: is iodine deficiency still a continuing problem? 61
30099723 2019
5
Interactive Effects of Exercise, Sex Hormones, and Transient Congenital Hypothyroidism on Long-Term Potentiation in Hippocampal Slices of Rat Offspring. 61
31031899 2019
6
Levothyroxine dosages less than 2.4 μg/kg/day at 1 year and 1.3 μg/kg/day at 3 years of age may predict transient congenital hypothyroidism. 61
31666765 2019
7
Levothyroxine Dosage as Predictor of Permanent and Transient Congenital Hypothyroidism: A Multicenter Retrospective Study in Japan. 61
31553976 2019
8
DUOX Defects and Their Roles in Congenital Hypothyroidism. 61
31172499 2019
9
Permanent vs Transient Congenital Hypothyroidism: Assessment of Predictive Variables. 61
30272179 2018
10
Newborn Screening Guidelines for Congenital Hypothyroidism in India: Recommendations of the Indian Society for Pediatric and Adolescent Endocrinology (ISPAE) - Part I: Screening and Confirmation of Diagnosis. 61
29380252 2018
11
A 7-year study on the prevalence of congenital hypothyroidism in northern Iran. 61
29881532 2018
12
Intelligence Quotient at the Age of Six years of Iranian Children with Congenital Hypothyroidism. 61
28952455 2018
13
Three-year follow-up of children with abnormal newborn screening results for congenital hypothyroidism. 61
28412200 2017
14
Maternal hypothyroidism: An overview of current experimental models. 61
28807719 2017
15
Transient hypothyroidism in the newborn: to treat or not to treat. 61
29184815 2017
16
Low Thyroid Hormone Levels Disrupt Thyrotrope Development. 61
28658938 2017
17
Predictors of transient congenital hypothyroidism in children with eutopic thyroid gland. 61
28690990 2017
18
[Transient congenital hypothyroidism due to biallelic defects of DUOX2 gene. Two clinical cases]. 61
28504502 2017
19
Transient Congenital Hypothyroidism Alters Gene Expression of Glucose Transporters and Impairs Glucose Sensing Apparatus in Young and Aged Offspring Rats. 61
29073628 2017
20
Permanent and Transient Congenital Hypothyroidism in Hamadan West Province of Iran. 61
28144251 2016
21
Can One Predict Resolution of Neonatal Hyperthyrotropinemia? 61
27189684 2016
22
Next-generation sequencing analysis of DUOX2 in 192 Chinese subclinical congenital hypothyroidism (SCH) and CH patients. 61
27108200 2016
23
Transient Congenital Hypothyroidism in Turkey: An Analysis on Frequency and Natural Course. 61
27086592 2016
24
Transient congenital hypothyroidism caused by compound heterozygous mutations affecting the NADPH-oxidase domain of DUOX2. 61
26565538 2016
25
Transient versus Permanent Congenital Hypothyroidism after the Age of 3 Years in Infants Detected on the First versus Second Newborn Screening Test in Oregon, USA. 61
27595483 2016
26
Mutation screening of DUOX2 in Chinese patients with congenital hypothyroidism. 61
26349762 2015
27
Hypothyroidism caused by the combination of two heterozygous mutations: one in the TSH receptor gene the other in the DUOX2 gene. 61
25928756 2015
28
Changes of antithroglobulin antibody in children with congenital hypothyroidism. 61
24904874 2013
29
Prevalence of Permanent Congenital Hypothyroidism in Children in Yazd, Central Iran. 61
26060662 2013
30
Prevalence of transient congenital hypothyroidism in central part of Iran. 61
24379847 2013
31
Intelligence quotient in children with congenital hypothyroidism: The effect of diagnostic and treatment variables. 61
24174944 2013
32
Intrauterine diagnosis and treatment of fetal goitrous hypothyroidism. 61
23002999 2013
33
Permanent and transient congenital hypothyroidism in Fayoum, Egypt: a descriptive retrospective study. 61
23840807 2013
34
Transient neonatal hypothyroidism in a boy with unbalanced translocation t(8;16). 61
23295299 2012
35
Prevalence of permanent and transient congenital hypothyroidism in Babol City -Iran. 61
22926374 2012
36
Permanent and transient congenital hypothyroidism in preterm infants. 61
22107264 2012
37
High prevalence of congenital hypothyroidism in Isfahan: Do familial components have a role? 61
23326768 2012
38
Transient congenital hypothyroidism. 61
21966647 2011
39
Transient congenital hypothyroidism due to thyroid-stimulating hormone receptor blocking antibodies: a case series. 61
21606073 2011
40
Compound heterozygosity for a novel hemizygous missense mutation and a partial deletion affecting the catalytic core of the H2O2-generating enzyme DUOX2 associated with transient congenital hypothyroidism. 61
20187165 2010
41
Permanent and transient congenital hypothyroidism in Isfahan-Iran. 61
19349525 2009
42
Transient congenital hypothyroidism caused by biallelic mutations of the dual oxidase 2 gene in Japanese patients detected by a neonatal screening program. 61
18765513 2008
43
Detection of circulating autoantibodies against thyroid hormones in an infant with permanent congenital hypothyroidism and her twin with transient congenital hypothyroidism: possible contribution of thyroid hormone autoantibodies to neonatal and infant hypothyroidism. 61
19209623 2008
44
[Transient neonatal hypothyroidism due to amiodarone administration during pregnancy--two cases report and review of literature]. 61
18345406 2008
45
Transient congenital hypothyroidism in an iodine-replete area is not related to parental consanguinity, mode of delivery, goitrogens, iodine exposure, or thyrotropin receptor autoantibodies. 61
18296902 2008
46
[Observation time for drug administration and withdrawal in the treatment of children with congenital hypothyroidism]. 61
17924470 2007
47
Transient neonatal hypothyroidism is associated with elevated serum anti-thyroglobulin antibody levels in newborns and their mothers. 61
17307555 2007
48
Risk factors for congenital hypothyroidism: results of a population case-control study (1997-2003). 61
16322381 2005
49
Treatment and follow-up of children with transient congenital hypothyroidism. 61
16358380 2005
50
Potent thyrotrophin receptor-blocking antibodies: a cause of transient congenital hypothyroidism and delayed thyroid development. 61
15012609 2004

Variations for Transient Congenital Hypothyroidism

Expression for Transient Congenital Hypothyroidism

Search GEO for disease gene expression data for Transient Congenital Hypothyroidism.

Pathways for Transient Congenital Hypothyroidism

Pathways related to Transient Congenital Hypothyroidism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.1 TSHR TPO DUOX2
2
Show member pathways
10.56 TPO DUOX2
3 9.4 TSHR TPO

GO Terms for Transient Congenital Hypothyroidism

Cellular components related to Transient Congenital Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.8 TSHR TPO DUOX2

Biological processes related to Transient Congenital Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 9.32 TPO DUOX2
2 cellular oxidant detoxification GO:0098869 9.26 TPO DUOX2
3 hydrogen peroxide catabolic process GO:0042744 9.16 TPO DUOX2
4 thyroid hormone generation GO:0006590 8.96 TPO DUOX2
5 hormone biosynthetic process GO:0042446 8.62 TPO DUOX2

Molecular functions related to Transient Congenital Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.96 TPO DUOX2
2 peroxidase activity GO:0004601 8.62 TPO DUOX2

Sources for Transient Congenital Hypothyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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