MCID: TRN047
MIFTS: 24

Transient Congenital Hypothyroidism

Categories: Endocrine diseases, Immune diseases, Metabolic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Transient Congenital Hypothyroidism

MalaCards integrated aliases for Transient Congenital Hypothyroidism:

Name: Transient Congenital Hypothyroidism 59

Classifications:

Orphanet: 59  
Rare endocrine diseases


External Ids:

Orphanet 59 ORPHA178045

Summaries for Transient Congenital Hypothyroidism

MalaCards based summary : Transient Congenital Hypothyroidism is related to goiter and thyroiditis. An important gene associated with Transient Congenital Hypothyroidism is DUOX2 (Dual Oxidase 2), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Amine-derived hormones. Affiliated tissues include thyroid, testes and breast, and related phenotypes are endocrine/exocrine gland and hearing/vestibular/ear

Related Diseases for Transient Congenital Hypothyroidism

Diseases in the Hypothyroidism family:

Congenital Hypothyroidism Central Congenital Hypothyroidism
Hypothyroidism Due to Iodide Transport Defect Rare Adult Hypothyroidism
Transient Congenital Hypothyroidism Rare Hypothyroidism
Primary Congenital Hypothyroidism Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Transient Congenital Hypothyroidism Due to Maternal Factor
Transient Congenital Hypothyroidism Due to Neonatal Factor Congenital Hypothyroidism Due to Transplacental Passage of Tsh-Binding Inhibitory Antibodies
Congenital Hypothyroidism Due to Developmental Anomaly

Diseases related to Transient Congenital Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 goiter 29.8 TSHR TPO
2 thyroiditis 29.8 TSHR TPO
3 congenital hypothyroidism 29.7 TSHR TPO DUOX2
4 hypothyroidism 29.7 TSHR TPO DUOX2
5 familial thyroid dyshormonogenesis 29.3 TPO DUOX2
6 hyperthyroidism 29.0 TSHR TPO
7 hashimoto thyroiditis 28.9 TSHR TPO
8 genetic transient congenital hypothyroidism 12.4
9 transient congenital hypothyroidism due to maternal factor 12.4
10 transient congenital hypothyroidism due to neonatal factor 12.4
11 permanent congenital hypothyroidism 10.1
12 hypothyroidism, congenital, nongoitrous, 2 9.8
13 primary congenital hypothyroidism 9.8
14 athyreosis 9.8
15 hashimoto encephalopathy 9.8 TSHR TPO
16 endemic goiter 9.8 TSHR TPO
17 nontoxic goiter 9.8 TSHR TPO
18 graves disease 1 9.8 TSHR TPO
19 subacute thyroiditis 9.8 TSHR TPO
20 hyperthyroxinemia 9.8 TSHR TPO
21 toxic diffuse goiter 9.7 TSHR TPO
22 myxedema 9.7 TSHR TPO
23 nodular goiter 9.7 TSHR TPO
24 autoimmune disease of endocrine system 9.7 TSHR TPO
25 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.7 TSHR TPO
26 multinodular goiter 9.7 TSHR TPO
27 thyroid gland disease 9.7 TSHR TPO
28 follicular adenoma 9.6 TSHR TPO
29 papillary carcinoma 9.6 TSHR TPO
30 differentiated thyroid carcinoma 9.5 TSHR TPO
31 pendred syndrome 9.5 TPO DUOX2
32 thyroid cancer, nonmedullary, 2 9.5 TSHR TPO
33 graves' disease 9.4 TSHR TPO

Graphical network of the top 20 diseases related to Transient Congenital Hypothyroidism:



Diseases related to Transient Congenital Hypothyroidism

Symptoms & Phenotypes for Transient Congenital Hypothyroidism

MGI Mouse Phenotypes related to Transient Congenital Hypothyroidism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.33 DUOX2 TPO TSHR
2 hearing/vestibular/ear MP:0005377 9.13 DUOX2 TPO TSHR
3 skeleton MP:0005390 8.8 DUOX2 TPO TSHR

Drugs & Therapeutics for Transient Congenital Hypothyroidism

Search Clinical Trials , NIH Clinical Center for Transient Congenital Hypothyroidism

Genetic Tests for Transient Congenital Hypothyroidism

Anatomical Context for Transient Congenital Hypothyroidism

MalaCards organs/tissues related to Transient Congenital Hypothyroidism:

41
Thyroid, Testes, Breast

Publications for Transient Congenital Hypothyroidism

Articles related to Transient Congenital Hypothyroidism:

(show top 50) (show all 70)
# Title Authors PMID Year
1
Audit of the Congenital Hypothyroidism Screening Program in 15 Provinces of Iran. 38
31356097 2019
2
Effects of mandatory salt iodization on breast milk, urinary iodine concentrations, and thyroid hormones: is iodine deficiency still a continuing problem? 38
30099723 2019
3
Interactive Effects of Exercise, Sex Hormones, and Transient Congenital Hypothyroidism on Long-Term Potentiation in Hippocampal Slices of Rat Offspring. 38
31031899 2019
4
DUOX Defects and Their Roles in Congenital Hypothyroidism. 38
31172499 2019
5
Permanent vs Transient Congenital Hypothyroidism: Assessment of Predictive Variables. 38
30272179 2018
6
Newborn Screening Guidelines for Congenital Hypothyroidism in India: Recommendations of the Indian Society for Pediatric and Adolescent Endocrinology (ISPAE) - Part I: Screening and Confirmation of Diagnosis. 38
29380252 2018
7
A 7-year study on the prevalence of congenital hypothyroidism in northern Iran. 38
29881532 2018
8
Intelligence Quotient at the Age of Six years of Iranian Children with Congenital Hypothyroidism. 38
28952455 2018
9
Maternal hypothyroidism: An overview of current experimental models. 38
28807719 2017
10
Three-year follow-up of children with abnormal newborn screening results for congenital hypothyroidism. 38
28412200 2017
11
Transient hypothyroidism in the newborn: to treat or not to treat. 38
29184815 2017
12
Low Thyroid Hormone Levels Disrupt Thyrotrope Development. 38
28658938 2017
13
[Transient congenital hypothyroidism due to biallelic defects of DUOX2 gene. Two clinical cases]. 38
28504502 2017
14
Predictors of transient congenital hypothyroidism in children with eutopic thyroid gland. 38
28690990 2017
15
Transient Congenital Hypothyroidism Alters Gene Expression of Glucose Transporters and Impairs Glucose Sensing Apparatus in Young and Aged Offspring Rats. 38
29073628 2017
16
Permanent and Transient Congenital Hypothyroidism in Hamadan West Province of Iran. 38
28144251 2016
17
Next-generation sequencing analysis of DUOX2 in 192 Chinese subclinical congenital hypothyroidism (SCH) and CH patients. 38
27108200 2016
18
Can One Predict Resolution of Neonatal Hyperthyrotropinemia? 38
27189684 2016
19
Transient Congenital Hypothyroidism in Turkey: An Analysis on Frequency and Natural Course. 38
27086592 2016
20
Transient congenital hypothyroidism caused by compound heterozygous mutations affecting the NADPH-oxidase domain of DUOX2. 38
26565538 2016
21
Transient versus Permanent Congenital Hypothyroidism after the Age of 3 Years in Infants Detected on the First versus Second Newborn Screening Test in Oregon, USA. 38
27595483 2016
22
Mutation screening of DUOX2 in Chinese patients with congenital hypothyroidism. 38
26349762 2015
23
Hypothyroidism caused by the combination of two heterozygous mutations: one in the TSH receptor gene the other in the DUOX2 gene. 38
25928756 2015
24
Changes of antithroglobulin antibody in children with congenital hypothyroidism. 38
24904874 2013
25
Prevalence of Permanent Congenital Hypothyroidism in Children in Yazd, Central Iran. 38
26060662 2013
26
Prevalence of transient congenital hypothyroidism in central part of Iran. 38
24379847 2013
27
Intelligence quotient in children with congenital hypothyroidism: The effect of diagnostic and treatment variables. 38
24174944 2013
28
Intrauterine diagnosis and treatment of fetal goitrous hypothyroidism. 38
23002999 2013
29
Permanent and transient congenital hypothyroidism in Fayoum, Egypt: a descriptive retrospective study. 38
23840807 2013
30
Transient neonatal hypothyroidism in a boy with unbalanced translocation t(8;16). 38
23295299 2012
31
Prevalence of permanent and transient congenital hypothyroidism in Babol City -Iran. 38
22926374 2012
32
Permanent and transient congenital hypothyroidism in preterm infants. 38
22107264 2012
33
High prevalence of congenital hypothyroidism in Isfahan: Do familial components have a role? 38
23326768 2012
34
Transient congenital hypothyroidism due to thyroid-stimulating hormone receptor blocking antibodies: a case series. 38
21606073 2011
35
Transient congenital hypothyroidism. 38
21966647 2011
36
Compound heterozygosity for a novel hemizygous missense mutation and a partial deletion affecting the catalytic core of the H2O2-generating enzyme DUOX2 associated with transient congenital hypothyroidism. 38
20187165 2010
37
Permanent and transient congenital hypothyroidism in Isfahan-Iran. 38
19349525 2009
38
Transient congenital hypothyroidism caused by biallelic mutations of the dual oxidase 2 gene in Japanese patients detected by a neonatal screening program. 38
18765513 2008
39
Detection of circulating autoantibodies against thyroid hormones in an infant with permanent congenital hypothyroidism and her twin with transient congenital hypothyroidism: possible contribution of thyroid hormone autoantibodies to neonatal and infant hypothyroidism. 38
19209623 2008
40
[Transient neonatal hypothyroidism due to amiodarone administration during pregnancy--two cases report and review of literature]. 38
18345406 2008
41
Transient congenital hypothyroidism in an iodine-replete area is not related to parental consanguinity, mode of delivery, goitrogens, iodine exposure, or thyrotropin receptor autoantibodies. 38
18296902 2008
42
[Observation time for drug administration and withdrawal in the treatment of children with congenital hypothyroidism]. 38
17924470 2007
43
Transient neonatal hypothyroidism is associated with elevated serum anti-thyroglobulin antibody levels in newborns and their mothers. 38
17307555 2007
44
Risk factors for congenital hypothyroidism: results of a population case-control study (1997-2003). 38
16322381 2005
45
Treatment and follow-up of children with transient congenital hypothyroidism. 38
16358380 2005
46
Potent thyrotrophin receptor-blocking antibodies: a cause of transient congenital hypothyroidism and delayed thyroid development. 38
15012609 2004
47
Transient congenital hypothyroidism due to maternal autoimmune thyroid disease. 38
17003010 2003
48
Hyperthyrotropinemia during iodide administration in normal children and in children born with neonatal transient hypothyroidism. 38
12574190 2003
49
Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism. 38
12110737 2002
50
Relation of basic and clinical research on foetal and neonatal thyroid pathology to neonatal thyroid screening. 38
10626569 1999

Variations for Transient Congenital Hypothyroidism

Expression for Transient Congenital Hypothyroidism

Search GEO for disease gene expression data for Transient Congenital Hypothyroidism.

Pathways for Transient Congenital Hypothyroidism

Pathways related to Transient Congenital Hypothyroidism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.9 TSHR TPO DUOX2
2
Show member pathways
10.76 TPO DUOX2
3 9.4 TSHR TPO

GO Terms for Transient Congenital Hypothyroidism

Biological processes related to Transient Congenital Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 9.32 TPO DUOX2
2 cellular oxidant detoxification GO:0098869 9.26 TPO DUOX2
3 hydrogen peroxide catabolic process GO:0042744 9.16 TPO DUOX2
4 thyroid hormone generation GO:0006590 8.96 TPO DUOX2
5 hormone biosynthetic process GO:0042446 8.62 TPO DUOX2

Molecular functions related to Transient Congenital Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.96 TPO DUOX2
2 peroxidase activity GO:0004601 8.62 TPO DUOX2

Sources for Transient Congenital Hypothyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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