TEC
MCID: TRN030
MIFTS: 37

Transient Erythroblastopenia of Childhood (TEC)

Categories: Blood diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Transient Erythroblastopenia of Childhood

MalaCards integrated aliases for Transient Erythroblastopenia of Childhood:

Name: Transient Erythroblastopenia of Childhood 58 77 54 60 13
Erythroblastopenia, Transient 58 54 56
Transient Acquired Pure Red Cell Aplasia 60 74
Tec 58 54
Familial Transient Erythroblastopenia of Childhood 54

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive


HPO:

33
transient erythroblastopenia of childhood:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 58 227050
ICD10 34 D60.1
MESH via Orphanet 46 C536980
ICD10 via Orphanet 35 D60.1
UMLS via Orphanet 75 C0238478
Orphanet 60 ORPHA98871
MedGen 43 C0238478
SNOMED-CT via HPO 70 258211005
UMLS 74 C0451688

Summaries for Transient Erythroblastopenia of Childhood

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 98871Disease definitionA rare, benign, red cell aplasia of young children or infants characterized by a normocytic normochromic anaemia with severe reticulocytopenia in otherwise normocellular bone marrow, and a complete spontaneous recovery within 1-2 months after diagnosis. Neutropenia and thrombocytosis may be associated findings at diagnosis, and a history of a preceding viral illness is frequent. No organomegaly is observed.Visit the Orphanet disease page for more resources.

MalaCards based summary : Transient Erythroblastopenia of Childhood, also known as erythroblastopenia, transient, is related to aplastic anemia and b cell deficiency. An important gene associated with Transient Erythroblastopenia of Childhood is TEC (Tec Protein Tyrosine Kinase), and among its related pathways/superpathways are Tyrosine Kinases / Adaptors and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include bone marrow, thyroid and neutrophil, and related phenotypes are transient erythroblastopenia and limbs/digits/tail

OMIM : 58 Transient erythroblastopenia of childhood is a pure red cell aplasia that occurs in a previously healthy child, most commonly between 6 months and 4 years of age. The course is characterized by a complete recovery, usually within 1 to 2 months after diagnosis. In most cases no therapy is necessary, although some children may need red cell transfusion (summary by Gustavsson et al., 2002). (227050)

Wikipedia : 77 Transient erythroblastopenia of childhood (TEC) is a slowly developing anemia of early childhood... more...

Related Diseases for Transient Erythroblastopenia of Childhood

Diseases related to Transient Erythroblastopenia of Childhood via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 aplastic anemia 29.3 EPO KITLG RPS19
2 b cell deficiency 11.6
3 cone-rod dystrophy and hearing loss 2 11.1
4 leishmaniasis 10.2
5 chondrosarcoma 10.1
6 chondrosarcoma, extraskeletal myxoid 10.1
7 extraosseous chondrosarcoma 10.1
8 myxoid chondrosarcoma 10.1
9 thyroiditis 10.1
10 visceral leishmaniasis 10.1
11 lymphomatous thyroiditis 10.1
12 hepatocellular carcinoma 10.1
13 candidiasis 10.1
14 breath-holding spells 10.0
15 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.0
16 hemolytic anemia 10.0
17 hepatitis 10.0
18 metabolic acidosis 10.0
19 congenital hypoplastic anemia 10.0
20 papilledema 10.0
21 agammaglobulinemia 10.0
22 transient hypogammaglobulinemia 10.0
23 bladder cancer 9.9
24 breast cancer 9.9
25 anemia, autoimmune hemolytic 9.9
26 myeloma, multiple 9.9
27 spondylocarpotarsal synostosis syndrome 9.9
28 asthma 9.9
29 endometrial cancer 9.9
30 lung cancer susceptibility 3 9.9
31 peripheral vascular disease 9.9
32 alcoholic hepatitis 9.9
33 neutropenia 9.9
34 vascular disease 9.9
35 acute pancreatitis 9.9
36 adenocarcinoma 9.9
37 pancreatitis 9.9
38 allergic asthma 9.9
39 bacterial meningitis 9.9
40 meningitis 9.9
41 acute respiratory distress syndrome 9.9
42 ewing's family of tumors 9.8 EPO KITLG
43 anemia of prematurity 9.8 EPO KITLG
44 polycythemia 9.7 EPO KITLG
45 polycythemia vera 9.7 EPO KITLG
46 deficiency anemia 9.7 EPO RPS19
47 bone marrow cancer 9.6 EPO KITLG
48 leukemia, chronic myeloid 9.5 EPO KITLG
49 diamond-blackfan anemia 9.5 EPO KITLG RPS19

Graphical network of the top 20 diseases related to Transient Erythroblastopenia of Childhood:



Diseases related to Transient Erythroblastopenia of Childhood

Symptoms & Phenotypes for Transient Erythroblastopenia of Childhood

Human phenotypes related to Transient Erythroblastopenia of Childhood:

33
# Description HPO Frequency HPO Source Accession
1 transient erythroblastopenia 33 HP:0005510

Symptoms via clinical synopsis from OMIM:

58
Heme:
anemia
transient erythroblastopenia

Clinical features from OMIM:

227050

MGI Mouse Phenotypes related to Transient Erythroblastopenia of Childhood:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.8 EPO KITLG RPS19

Drugs & Therapeutics for Transient Erythroblastopenia of Childhood

Search Clinical Trials , NIH Clinical Center for Transient Erythroblastopenia of Childhood

Genetic Tests for Transient Erythroblastopenia of Childhood

Anatomical Context for Transient Erythroblastopenia of Childhood

MalaCards organs/tissues related to Transient Erythroblastopenia of Childhood:

42
Bone Marrow, Thyroid, Neutrophil, T Cells, Myeloid, B Cells

Publications for Transient Erythroblastopenia of Childhood

Articles related to Transient Erythroblastopenia of Childhood:

(show top 50) (show all 54)
# Title Authors Year
1
Transient Erythroblastopenia of Childhood: A Review for the Pediatric Emergency Medicine Physician. ( 30817707 )
2019
2
Deformation of erythroblasts in transient erythroblastopenia of childhood caused by HHV-6. ( 28092892 )
2016
3
Transient erythroblastopenia of childhood is an underdiagnosed and self-limiting disease. ( 24635829 )
2014
4
Concomitant transient erythroblastopenia of childhood with neonatal hepatitis. ( 22335327 )
2012
5
Ectopic atrial tachycardia in an infant with transient erythroblastopenia of childhood. ( 21730806 )
2011
6
Transient erythroblastopenia of childhood in siblings: case report and review of the literature. ( 17805047 )
2007
7
Classic transient erythroblastopenia of childhood with human parvovirus B19 genome detection in the blood and bone marrow. ( 15956889 )
2005
8
Transient erythroblastopenia of childhood: prospective study of 10 patients with special reference to viral infections. ( 11972099 )
2002
9
Familial transient erythroblastopenia of childhood is associated with the chromosome 19q13.2 region but not caused by mutations in coding sequences of the ribosomal protein S19 (RPS19) gene. ( 12358933 )
2002
10
Case of transient erythroblastopenia of childhood with transient hypogammaglobulinemia. ( 10804733 )
2000
11
Transient erythroblastopenia of childhood associated with transient neurologic deficit: report of a case and review of the literature. ( 9633983 )
1998
12
Bone marrow biopsy findings in childhood anemia: prevalence of transient erythroblastopenia of childhood. ( 9674545 )
1998
13
Breath-holding spells in a patient with transient erythroblastopenia of childhood. ( 9108866 )
1997
14
Transient erythroblastopenia of childhood (TEC) presenting as leukoerythroblastic anemia. ( 9149751 )
1997
15
Transient erythroblastopenia of childhood associated with human herpesvirus type 6, variant B. ( 9260752 )
1997
16
Glycosylated haemoglobin and transient erythroblastopenia of childhood. ( 8551925 )
1996
17
Polymerase chain reaction amplification of archival material for parvovirus B19 in children with transient erythroblastopenia of childhood. ( 9025846 )
1996
18
Transient erythroblastopenia of childhood presenting with shock and metabolic acidosis. ( 7845854 )
1994
19
Transient erythroblastopenia of childhood. Prospective study of fifty patients. ( 7978049 )
1994
20
Transient erythroblastopenia of childhood in infants < 6 months of age. ( 8037344 )
1994
21
Transient erythroblastopenia of childhood. Evidence for cell-mediated suppression of erythropoiesis. ( 8214360 )
1993
22
Transient erythroblastopenia of childhood in Sweden: incidence and findings at the time of diagnosis. ( 8338993 )
1993
23
Age dependency of red blood cell deformability and density: studies in transient erythroblastopenia of childhood. ( 8435319 )
1993
24
Parvovirus B19 and transient erythroblastopenia of childhood. ( 8518188 )
1993
25
Transient erythroblastopenia of childhood presenting with echovirus 11 infection. ( 8518530 )
1993
26
Human parvovirus infection and transient erythroblastopenia of childhood. ( 1327065 )
1992
27
Transient erythroblastopenia of childhood with megakaryocytopenia associated with human parvovirus B19 infection. ( 1536802 )
1992
28
Immature lymphocytes in transient erythroblastopenia of childhood. ( 1907620 )
1991
29
Increase of CALLA-positive stimulated lymphoid cells in transient erythroblastopenia of childhood. ( 2140775 )
1990
30
Transient erythroblastopenia of childhood with CD10, TdT, and cytoplasmic mu lymphocyte positivity in bone marrow. ( 2146287 )
1990
31
Transient erythroblastopenia of childhood due to human parvovirus B19 infection. ( 2553096 )
1989
32
Transient erythroblastopenia of childhood. A review of 26 cases and reassessment of indications for bone marrow aspiration. ( 2718996 )
1989
33
Transient erythroblastopenia of childhood: implications for nurse practitioners. ( 2754596 )
1989
34
AMP deaminase as a cell-age marker in transient erythroblastopenia of childhood and its role in the adenylate economy of erythrocytes. ( 2804355 )
1989
35
Reduced neutrophil counts in children with transient erythroblastopenia of childhood. ( 2809908 )
1989
36
Seasonal clustering of transient erythroblastopenia of childhood. ( 2829620 )
1988
37
Transient erythroblastopenia of childhood. ( 18750483 )
1988
38
Transient neurological disorder associated with transient erythroblastopenia of childhood. ( 3592128 )
1987
39
Transient erythroblastopenia of childhood presenting with papilledema. ( 3698450 )
1986
40
Transient erythroblastopenia of childhood not associated with human parvovirus infection. ( 2869252 )
1986
41
Age-related red cell enzymes in children with transient erythroblastopenia of childhood and with hemolytic anemia. ( 2982125 )
1985
42
T-cell mediated inhibition of erythropoiesis in transient erythroblastopenia of childhood. ( 3871630 )
1985
43
Variable in vitro erythropoiesis in patients with transient erythroblastopenia of childhood. ( 4013369 )
1985
44
Transient erythroblastopenia of childhood. A review of 22 cases. ( 6593224 )
1984
45
Transient erythroblastopenia of childhood: varied pathogenesis. ( 6846328 )
1983
46
Nursing care study: transient erythroblastopenia of childhood. ( 6907956 )
1981
47
Fetal-like erythropoiesis during recovery from transient erythroblastopenia of childhood (TEC). ( 7254949 )
1981
48
Transient erythroblastopenia of childhood presenting with reticulocytosis and erythroid hyperplasia in the bone marrow. ( 7254979 )
1981
49
Transient erythroblastopenia of childhood. ( 7271473 )
1981
50
Transient erythroblastopenia of childhood. Review of 17 cases, including a pair of identical twins. ( 7293995 )
1981

Variations for Transient Erythroblastopenia of Childhood

Expression for Transient Erythroblastopenia of Childhood

Search GEO for disease gene expression data for Transient Erythroblastopenia of Childhood.

Pathways for Transient Erythroblastopenia of Childhood

GO Terms for Transient Erythroblastopenia of Childhood

Biological processes related to Transient Erythroblastopenia of Childhood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.16 KITLG TEC
2 erythrocyte differentiation GO:0030218 8.96 EPO RPS19
3 positive regulation of Ras protein signal transduction GO:0046579 8.62 EPO KITLG

Molecular functions related to Transient Erythroblastopenia of Childhood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.62 EPO KITLG

Sources for Transient Erythroblastopenia of Childhood

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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