MCID: TRN012
MIFTS: 40

Transient Global Amnesia

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Transient Global Amnesia

MalaCards integrated aliases for Transient Global Amnesia:

Name: Transient Global Amnesia 12 74 52 15 32
Amnesia, Transient Global 74 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:13027
ICD9CM 34 437.7
MeSH 43 D020236
NCIt 49 C85198
ICD10 32 G45.4
UMLS 71 C0338591

Summaries for Transient Global Amnesia

NIH Rare Diseases : 52 Transient global amnesia (TGA) is a condition characterized by sudden onset of memory loss and confusion. During an episode of TGA, a person is not able to make new memories. The person may be disoriented in regard to time and place, but can remember who they are and can recognize family members. TGA typically lasts for several hours, but can last up to ten hours. Since no memories are made during a TGA episode, the person will never remember what happened during this period, but all other memory is usually intact. Most people have only one episode of TGA during their lifetime. The underlying cause of TGA is unclear. There is no specific treatment for TGA as it usually resolves on its own.

MalaCards based summary : Transient Global Amnesia, also known as amnesia, transient global, is related to retrograde amnesia and amnestic disorder. An important gene associated with Transient Global Amnesia is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Nitric oxide stimulates guanylate cyclase and Erythrocytes take up carbon dioxide and release oxygen. The drugs Dalteparin and Argatroban have been mentioned in the context of this disorder. Affiliated tissues include heart, temporal lobe and pituitary, and related phenotypes are integument and vision/eye

Disease Ontology : 12 An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories.

Wikipedia : 74 Transient global amnesia (TGA) is a neurological disorder whose key defining characteristic is a... more...

Related Diseases for Transient Global Amnesia

Diseases related to Transient Global Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 retrograde amnesia 31.6 CA4 BDNF
2 amnestic disorder 31.5 LGI1 BDNF
3 anterograde amnesia 31.1 LGI1 BDNF
4 migraine with or without aura 1 30.7 TREX1 PDE5A NOTCH3 BDNF
5 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 29.6 TREX1 NOTCH3
6 cerebrovascular disease 10.7
7 transient cerebral ischemia 10.6
8 ischemia 10.5
9 meningioma, radiation-induced 10.4
10 meningioma, familial 10.4
11 spinal meningioma 10.4
12 secretory meningioma 10.4
13 lymphoplasmacyte-rich meningioma 10.4
14 head injury 10.4
15 headache 10.4
16 stroke, ischemic 10.4
17 epilepsy 10.4
18 atrial standstill 1 10.3
19 vascular disease 10.3
20 encephalitis 10.3
21 encephalopathy 10.3
22 thrombosis 10.3
23 broken heart syndrome 10.3
24 hypercholesterolemia, familial, 1 10.2
25 homocysteinemia 10.2
26 aphasia 10.2
27 hydrocephalus 10.2
28 dissociative amnesia 10.2
29 visual epilepsy 10.2
30 migraine without aura 10.2
31 patent foramen ovale 10.2
32 thrombocytopenia 10.2
33 impotence 10.2
34 temporal lobe epilepsy 10.2
35 dystonia 10.2
36 polycythemia 10.2
37 acute myocardial infarction 10.2
38 heparin-induced thrombocytopenia 10.2
39 seizure disorder 10.2
40 liver rhabdomyosarcoma 10.2 CA4 CA1
41 thrombophilia due to thrombin defect 10.1
42 yemenite deaf-blind hypopigmentation syndrome 10.1
43 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 10.1
44 myocardial infarction 10.1
45 migraine with aura 10.1
46 cortical blindness 10.1
47 arteriosclerosis 10.1
48 antiphospholipid syndrome 10.1
49 lipid metabolism disorder 10.1
50 aortic aneurysm 10.1

Comorbidity relations with Transient Global Amnesia via Phenotypic Disease Network (PDN):


Hypertension, Essential Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Transient Global Amnesia:



Diseases related to Transient Global Amnesia

Symptoms & Phenotypes for Transient Global Amnesia

MGI Mouse Phenotypes related to Transient Global Amnesia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.43 BDNF BLOC1S6 KLF6 LGI1 NOTCH3 TREX1
2 vision/eye MP:0005391 9.1 BDNF BLOC1S6 CA4 LGI1 NOTCH3 TREX1

Drugs & Therapeutics for Transient Global Amnesia

Drugs for Transient Global Amnesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dalteparin Approved Phase 3 9005-49-6
2
Argatroban Approved, Investigational Phase 3 74863-84-6 152951
3
Thrombin Approved, Investigational Phase 3
4 Antithrombins Phase 3
5 Fibrinolytic Agents Phase 3
6 HIV Protease Inhibitors Phase 3
7
protease inhibitors Phase 3
8 Platelet Aggregation Inhibitors Phase 3
9 Serine Proteinase Inhibitors Phase 3
10 Anticoagulants Phase 3
11 Heparin, Low-Molecular-Weight Phase 3
12 Antithrombin III Phase 3
13 Dermatan Sulfate Phase 3
14
Serine Investigational, Nutraceutical Phase 3 56-45-1 5951

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-Label, Randomised, Active Controlled, Multi-Centre Phase 3 Study to Evaluate the Safety and Efficacy of Danaparoid vs Argatroban in Treatment of Subjects With Acute HIT (HITSOVA Study) Recruiting NCT03809481 Phase 3 Danaparoid Sodium;Argatroban
2 Reversible Cerebral Vasoconstriction Syndrome With Concomitant Transient Global Amnesia : a Serie of 3 Cases Report Completed NCT03739008
3 Transient Global Amnesia (TGA) Exploratory Study of the Default Mode Network in Resting State Functional MRI (fMRI) During the Acute Phase Completed NCT02010853
4 Perioperative Changes of Cognitive Function According to Jugular Vein Insufficiency in Robot-assisted Prostatectomy Completed NCT01905488
5 Neuropsycholgy and Neuroimaging in Transient Global Amnesia Terminated NCT02562560
6 Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia Terminated NCT02796287

Search NIH Clinical Center for Transient Global Amnesia

Cochrane evidence based reviews: amnesia, transient global

Genetic Tests for Transient Global Amnesia

Anatomical Context for Transient Global Amnesia

MalaCards organs/tissues related to Transient Global Amnesia:

40
Heart, Temporal Lobe, Pituitary, Brain, Cortex, Testes, Bone Marrow

Publications for Transient Global Amnesia

Articles related to Transient Global Amnesia:

(show top 50) (show all 912)
# Title Authors PMID Year
1
Transient global amnesia. 61 52
26646345 2015
2
Transient global amnesia. 61 52
25659242 2015
3
Concomitant reversible cerebral vasoconstriction syndrome and transient global amnesia. 61
31650256 2020
4
Time trends, frequency, characteristics and prognosis of short-duration transient global amnesia. 61
32012408 2020
5
What remains after transient global amnesia (TGA)? An ultra-high field 7 T magnetic resonance imaging study of the hippocampus. 61
31573112 2020
6
Transient global amnesia with bilateral hippocampal lesions: report of two cases. 61
31925753 2020
7
Serum cortisol levels in patients with a transient global amnesia. 61
31987629 2020
8
Interaction between the heart and the brain in transient global amnesia. 61
31506826 2019
9
A controlled Valsalva Maneuver causes neither Diffusion-Positive Hippocampal Lesions nor Clinical Symptoms after Transient Global Amnesia. 61
31846963 2019
10
Emergency department visits for transient global amnesia alone or in association with substance abuse. 61
31625306 2019
11
[A case of recurrent transient global amnesia showing different symptom duration and MRI findings]. 61
31474643 2019
12
Transient Global Amnesia in a 60-year-old female with Post-traumatic Stress Disorder. 61
31728239 2019
13
Gadolinium leakage in ocular structures: A novel MRI finding in transient global amnesia. 61
31330456 2019
14
Long-Term Risk of Stroke After Transient Global Amnesia in Two Prospective Cohorts. 61
31284848 2019
15
Transient hippocampal CA1 lesions in humans impair pattern separation performance. 61
30706576 2019
16
SREDA: A Rare but Confusing Benign EEG Variant. 61
31393275 2019
17
Myocardial injury in transient global amnesia: a case-control study. 61
30706590 2019
18
Recurrent transient global amnesia associated with internal jugular vein thrombosis. 61
31128457 2019
19
Impaired Smooth Pursuit During Transient Global Amnesia. 61
31286700 2019
20
Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled. 61
31303492 2019
21
Tissue Level Mechanical Properties and Extracellular Matrix Investigation of the Bovine Jugular Venous Valve Tissue. 61
31091689 2019
22
Sex Differences in Presentation and Outcome After an Acute Transient or Minor Neurologic Event. 61
31114842 2019
23
Abnormal EEG Power Spectra in Acute Transient Global Amnesia: A Quantitative EEG Study. 61
29877098 2019
24
Optimization of magnetic resonance imaging protocol for the diagnosis of transient global amnesia. 61
31210688 2019
25
Transient Global Amnesia in a Patient with Pituitary Adenoma: Causal or Chance Association? 61
31572159 2019
26
Transient global amnesia and transient cortical blindness secondary to contrast induced encephalopathy after renal artery angiography. 61
30929878 2019
27
Transient Global Amnesia Secondary to Atherosclerotic Stenosis of Accessory Posterior Cerebral Artery. 61
30709618 2019
28
Transient global amnesia associated with sildenafil use. Report of one case. 61
31344218 2019
29
The Risk of Takotsubo Cardiomyopathy in Acute Neurological Disease. 61
30094686 2019
30
Strong Association Between Migraine and Transient Global Amnesia: A National Inpatient Sample Analysis. 61
30305003 2019
31
Transient global amnesia: clinical features and prognostic factors suggesting recurrence. 61
30758436 2019
32
Transient global amnesia. Have you considered hyperhomocysteinemia? 61
31664355 2019
33
Enhanced cortisol secretion in acute transient global amnesia. 61
30193207 2019
34
Resting-state connectivity alterations during transient global amnesia. 61
31153000 2019
35
Transient global amnesia: an intriguing yet benign disturbance. 61
30758435 2019
36
Seasonal variations in the occurrence of transient global amnesia (TGA). 61
31162624 2019
37
Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report. 61
30678717 2019
38
Transient Global Amnesia as the Sole Presentation of an Acute Stroke in the Left Cingulate Gyrus. 61
30915247 2019
39
Transient Global Amnesia Linked to Impairment of Brain Venous Drainage: An Ultrasound Investigation. 61
30804883 2019
40
Vertebral artery loop in a case of recurrent transient global amnesia. 61
30504067 2019
41
The Long-Term Risk of Dementia after Transient Global Amnesia: A Population-Based Cohort Study in Taiwan. 61
31422402 2019
42
Prolonged allocentric navigation deficits indicate hippocampal damage in TGA. 61
30552301 2019
43
A Case of Posterior Reversible Encephalopathy Syndrome with Similar Symptoms as Transient Global Amnesia. 61
30906408 2018
44
Some thoughts about concomitant transient global amnesia and takotsubo syndrome. 61
30151690 2018
45
Juvenile absence epilepsy relapsing as recurrent absence status, mimicking transient global amnesia, in an elderly patient. 61
30530409 2018
46
Concomitant transient global amnesia and takotsubo cardiomyopathy following a stressful event. 61
30094523 2018
47
Temporary Memory Steal: Transient Global Amnesia Secondary to Nephrolithiasis. 61
30443620 2018
48
Transient epileptic and global amnesia: Real-life differential diagnosis. 61
30296664 2018
49
Transient global amnesia: Minor inconvenience or early warning sign? 61
30069134 2018
50
Dural Arteriovenous Fistula Causing Recurrent Transient Global Amnesia. 61
30245773 2018

Variations for Transient Global Amnesia

Expression for Transient Global Amnesia

Search GEO for disease gene expression data for Transient Global Amnesia.

Pathways for Transient Global Amnesia

Pathways related to Transient Global Amnesia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.78 PDE5A PDE11A
2
Show member pathways
10.5 CA4 CA1
3
Show member pathways
10.09 CA4 CA1

GO Terms for Transient Global Amnesia

Biological processes related to Transient Global Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bicarbonate transport GO:0015701 8.62 CA4 CA1

Molecular functions related to Transient Global Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 3',5'-cyclic-GMP phosphodiesterase activity GO:0047555 9.32 PDE5A PDE11A
2 cGMP binding GO:0030553 9.26 PDE5A PDE11A
3 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114 9.16 PDE5A PDE11A
4 carbonate dehydratase activity GO:0004089 8.96 CA4 CA1
5 cyclic-nucleotide phosphodiesterase activity GO:0004112 8.62 PDE5A PDE11A

Sources for Transient Global Amnesia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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