MCID: TRN012
MIFTS: 38

Transient Global Amnesia

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Transient Global Amnesia

MalaCards integrated aliases for Transient Global Amnesia:

Name: Transient Global Amnesia 12 74 20 15 32
Amnesia, Transient Global 74 44 71

Classifications:



External Ids:

Disease Ontology 12 DOID:13027
ICD9CM 34 437.7
MeSH 44 D020236
NCIt 50 C85198
SNOMED-CT 67 366963000
ICD10 32 G45.4
UMLS 71 C0338591

Summaries for Transient Global Amnesia

GARD : 20 Transient global amnesia (TGA) is a condition characterized by sudden onset of memory loss and confusion. During an episode of TGA, a person is not able to make new memories. The person may be disoriented in regard to time and place, but can remember who they are and can recognize family members. TGA typically lasts for several hours, but can last up to ten hours. Since no memories are made during a TGA episode, the person will never remember what happened during this period, but all other memory is usually intact. Most people have only one episode of TGA during their lifetime. The underlying cause of TGA is unclear. There is no specific treatment for TGA as it usually resolves on its own.

MalaCards based summary : Transient Global Amnesia, also known as amnesia, transient global, is related to anterograde amnesia and retrograde amnesia. An important gene associated with Transient Global Amnesia is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Nitric oxide stimulates guanylate cyclase and Erythrocytes take up carbon dioxide and release oxygen. The drug Fluorodeoxyglucose F18 has been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and cortex.

Disease Ontology : 12 An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories.

Wikipedia : 74 Transient global amnesia (TGA) is a neurological disorder whose key defining characteristic is a... more...

Related Diseases for Transient Global Amnesia

Diseases related to Transient Global Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 anterograde amnesia 31.6 CA4 BDNF
2 retrograde amnesia 31.5 CA4 BDNF
3 amnestic disorder 11.5
4 migraine with or without aura 1 10.9
5 cerebrovascular disease 10.7
6 transient cerebral ischemia 10.6
7 head injury 10.5
8 meningioma, familial 10.4
9 spinal meningioma 10.4
10 secretory meningioma 10.4
11 lymphoplasmacyte-rich meningioma 10.4
12 atrial standstill 1 10.4
13 aortic dissection 10.4
14 epilepsy 10.4
15 broken heart syndrome 10.4
16 thrombosis 10.3
17 vascular disease 10.3
18 impotence 10.3
19 lipid metabolism disorder 10.3
20 ischemia 10.3
21 headache 10.3
22 hypercholesterolemia, familial, 1 10.2
23 stroke, ischemic 10.2
24 homocysteinemia 10.2
25 aphasia 10.2
26 mild cognitive impairment 10.2
27 hydrocephalus 10.2
28 dissociative amnesia 10.2
29 migraine without aura 10.2
30 thrombocytopenia 10.2
31 temporal lobe epilepsy 10.2
32 dystonia 10.2
33 polycythemia 10.2
34 acute myocardial infarction 10.2
35 encephalitis 10.2
36 heparin-induced thrombocytopenia 10.2
37 encephalopathy 10.2
38 sexual sadism 10.2 PDE5A BDNF
39 yemenite deaf-blind hypopigmentation syndrome 10.2
40 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 10.2
41 myocardial infarction 10.2
42 sleep apnea 10.2
43 migraine with aura 10.2
44 cortical blindness 10.2
45 patent foramen ovale 10.2
46 arteriosclerosis 10.2
47 antiphospholipid syndrome 10.2
48 aortic aneurysm 10.2
49 pituitary adenoma 10.2
50 systemic scleroderma 10.2

Comorbidity relations with Transient Global Amnesia via Phenotypic Disease Network (PDN):


Hypertension, Essential Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Transient Global Amnesia:



Diseases related to Transient Global Amnesia

Symptoms & Phenotypes for Transient Global Amnesia

Drugs & Therapeutics for Transient Global Amnesia

Drugs for Transient Global Amnesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fluorodeoxyglucose F18

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Reversible Cerebral Vasoconstriction Syndrome With Concomitant Transient Global Amnesia : a Serie of 3 Cases Report Completed NCT03739008
2 Transient Global Amnesia (TGA) Exploratory Study of the Default Mode Network in Resting State Functional MRI (fMRI) During the Acute Phase Completed NCT02010853
3 Coordination of Rare Diseases at Sanford Recruiting NCT01793168
4 Assessment of Emotional Memory During Transient Global Amnesia Not yet recruiting NCT04548037
5 Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia Terminated NCT02796287
6 Neuropsycholgy and Neuroimaging in Transient Global Amnesia Terminated NCT02562560

Search NIH Clinical Center for Transient Global Amnesia

Cochrane evidence based reviews: amnesia, transient global

Genetic Tests for Transient Global Amnesia

Anatomical Context for Transient Global Amnesia

MalaCards organs/tissues related to Transient Global Amnesia:

40
Brain, Temporal Lobe, Cortex, Pituitary, Bone Marrow, Prefrontal Cortex, Thalamus

Publications for Transient Global Amnesia

Articles related to Transient Global Amnesia:

(show top 50) (show all 950)
# Title Authors PMID Year
1
Transient global amnesia. 20 61
26646345 2015
2
Transient global amnesia. 61 20
25659242 2015
3
Conventional cardiovascular risk factors in Transient Global Amnesia: Systematic review and proposition of a novel hypothesis. 61
33539928 2021
4
Retrosplenial stroke mimicking transient global amnesia. 61
33431103 2021
5
Migraine in transient global amnesia: a meta-analysis of observational studies. 61
33388926 2021
6
[A case of transient global amnesia associated with painless myocardial infarction]. 61
33504749 2021
7
Prevalence of Mimics and Severe Comorbidity in Patients with Clinically Suspected Transient Global Amnesia. 61
33412553 2021
8
A case of transient global amnesia with hippocampal infarction due to infective endocarditis. 61
33485796 2021
9
An image is not always worth a thousand words: an image mimic of transient global amnesia. 61
33462633 2021
10
Transient global amnesia and focal diffusion weighted imaging lesions in mesiotemporal region: A ten-year experience. 61
33592368 2021
11
The long-term prognosis of Transient Global Amnesia: a systematic review. 61
33550779 2021
12
Effective connectivity alteration according to recurrence in transient global amnesia. 61
33486582 2021
13
Transient global amnesia with bilateral hippocampal lesions: report of two cases. 61
31925753 2020
14
Journal Club: Diffusion-weighted MRI in Transient Global Amnesia and its Diagnostic Implications. 61
33310875 2020
15
A multicenter study of transient global amnesia for the better detection of magnetic resonance imaging abnormalities. 61
32558010 2020
16
Transient Global Amnesia: A Diffusion and Perfusion MRI study. 61
32598567 2020
17
Testicular dislocation: An atypical case and review of the literature. 61
33102103 2020
18
Shedding light on the clinical recognition process of transient global amnesia. 61
32484252 2020
19
Risk factors predicting recurrence of transient global amnesia. 61
33033897 2020
20
The long-term risk of epilepsy after transient global amnesia: A population-based cohort study. 61
32683198 2020
21
Power Spectral Differences between Transient Epileptic and Global Amnesia: An eLORETA Quantitative EEG Study. 61
32899970 2020
22
Highlighting the classical MRI findings in transient global amnesia. 61
33029375 2020
23
The distribution of the transient global amnesia in the province of Ferrara, Italy, a clue to the pathogenesis? 61
32889591 2020
24
Transient global amnesia following carotid artery stenting: A case report. 61
32528605 2020
25
Potentially Reversible and Recognizable Acute Encephalopathic Syndromes: Disease Categorization and MRI Appearances. 61
32616580 2020
26
Factors Associated With Risk of Recurrent Transient Global Amnesia. 61
32865551 2020
27
Long-term risk of depression after transient global amnesia: A population-based study. 61
32333492 2020
28
Diffusion-weighted MRI in transient global amnesia and its diagnostic implications. 61
32532848 2020
29
Diagnosing Transient Global Amnesia Requires Exclusion of Alternative Differentials. 61
32695983 2020
30
Recurrent transient global amnesia after intracavernous Caverject injection in erectile dysfunction after robotic prostatectomy. 61
32280597 2020
31
Any Recent Stressors?-A Memoir of Transient Global Amnesia. 61
32478803 2020
32
Acute amnestic syndromes. 61
32203745 2020
33
Structural Connectivity and Cortical Thickness Alterations in Transient Global Amnesia. 61
32381542 2020
34
For how long is memory lost in transient global amnesia? 61
32096297 2020
35
Time trends, frequency, characteristics and prognosis of short-duration transient global amnesia. 61
32012408 2020
36
Serum cortisol levels in patients with a transient global amnesia. 61
31987629 2020
37
Transient Global Amnesia - Risk Factors and Putative Background. 61
32643675 2020
38
SREDA: A Rare but Confusing Benign EEG Variant. 61
31393275 2020
39
Transient global amnesia following transoesophageal echocardiography. 61
32350056 2020
40
Positive Magnetic Resonance Imaging Evidence of Transient Global Amnesia Following the Use of Sildenafil. 61
32106140 2020
41
Factors determining recurrence in transient global amnesia. 61
32143587 2020
42
What remains after transient global amnesia (TGA)? An ultra-high field 7 T magnetic resonance imaging study of the hippocampus. 61
31573112 2020
43
Concomitant reversible cerebral vasoconstriction syndrome and transient global amnesia. 61
31650256 2020
44
Increased incidence of transient global amnesia during the Covid-19 crisis? 61
32954213 2020
45
Post-concussion Vulnerability to Transient Global Amnesia. 61
33262736 2020
46
Transient Global Amnesia: An Electrophysiological Disorder Based on Cortical Spreading Depression-Transient Global Amnesia Model. 61
33363460 2020
47
Transient Global Amnesia in a Patient Presenting with Hypertensive Emergency; a Case Report. 61
33134962 2020
48
Atypical Neuromyelitis Optica Spectrum Disorder With Diffuse Cerebral Abnormalities: A Case Report. 61
33281464 2020
49
Interaction between the heart and the brain in transient global amnesia. 61
31506826 2019
50
Emergency department visits for transient global amnesia alone or in association with substance abuse. 61
31625306 2019

Variations for Transient Global Amnesia

Expression for Transient Global Amnesia

Search GEO for disease gene expression data for Transient Global Amnesia.

Pathways for Transient Global Amnesia

Pathways related to Transient Global Amnesia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.78 PDE5A PDE11A
2
Show member pathways
10.5 CA4 CA1
3
Show member pathways
10.09 CA4 CA1

GO Terms for Transient Global Amnesia

Biological processes related to Transient Global Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of synapse assembly GO:0051965 9.16 EPHB3 BDNF
2 bicarbonate transport GO:0015701 8.96 CA4 CA1
3 one-carbon metabolic process GO:0006730 8.62 CA4 CA1

Molecular functions related to Transient Global Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphoric diester hydrolase activity GO:0008081 9.37 PDE5A PDE11A
2 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114 9.32 PDE5A PDE11A
3 hydro-lyase activity GO:0016836 9.26 CA4 CA1
4 cGMP binding GO:0030553 9.16 PDE5A PDE11A
5 carbonate dehydratase activity GO:0004089 8.96 CA4 CA1
6 3',5'-cyclic-GMP phosphodiesterase activity GO:0047555 8.62 PDE5A PDE11A

Sources for Transient Global Amnesia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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