MCID: TRN012
MIFTS: 39

Transient Global Amnesia

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Transient Global Amnesia

MalaCards integrated aliases for Transient Global Amnesia:

Name: Transient Global Amnesia 12 74 52 15 32
Amnesia, Transient Global 74 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:13027
ICD9CM 34 437.7
MeSH 43 D020236
NCIt 49 C85198
SNOMED-CT 67 230736007
ICD10 32 G45.4
UMLS 71 C0338591

Summaries for Transient Global Amnesia

NIH Rare Diseases : 52 Transient global amnesia (TGA) is a condition characterized by sudden onset of memory loss and confusion. During an episode of TGA, a person is not able to make new memories. The person may be disoriented in regard to time and place, but can remember who they are and can recognize family members. TGA typically lasts for several hours, but can last up to ten hours. Since no memories are made during a TGA episode, the person will never remember what happened during this period, but all other memory is usually intact. Most people have only one episode of TGA during their lifetime. The underlying cause of TGA is unclear. There is no specific treatment for TGA as it usually resolves on its own.

MalaCards based summary : Transient Global Amnesia, also known as amnesia, transient global, is related to amnestic disorder and retrograde amnesia. An important gene associated with Transient Global Amnesia is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Nitric oxide stimulates guanylate cyclase and O2/CO2 exchange in erythrocytes. The drugs Thrombin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and heart.

Disease Ontology : 12 An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories.

Wikipedia : 74 Transient global amnesia (TGA) is a neurological disorder whose key defining characteristic is a... more...

Related Diseases for Transient Global Amnesia

Diseases related to Transient Global Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 amnestic disorder 31.9 LGI1 BDNF
2 retrograde amnesia 31.7 CA4 BDNF
3 anterograde amnesia 31.1 LGI1 CA4 BDNF
4 encephalomalacia 29.9 LGI1 BDNF
5 migraine with or without aura 1 10.9
6 cerebrovascular disease 10.7
7 transient cerebral ischemia 10.6
8 ischemia 10.5
9 head injury 10.4
10 meningioma, radiation-induced 10.4
11 meningioma, familial 10.4
12 spinal meningioma 10.4
13 secretory meningioma 10.4
14 lymphoplasmacyte-rich meningioma 10.4
15 headache 10.4
16 atrial standstill 1 10.4
17 stroke, ischemic 10.4
18 aortic dissection 10.4
19 vascular disease 10.3
20 epilepsy 10.3
21 broken heart syndrome 10.3
22 encephalopathy 10.3
23 thrombosis 10.3
24 impotence 10.3
25 encephalitis 10.3
26 hypercholesterolemia, familial, 1 10.2
27 homocysteinemia 10.2
28 aphasia 10.2
29 hydrocephalus 10.2
30 dissociative amnesia 10.2
31 visual epilepsy 10.2
32 migraine without aura 10.2
33 patent foramen ovale 10.2
34 thrombocytopenia 10.2
35 temporal lobe epilepsy 10.2
36 dystonia 10.2
37 polycythemia 10.2
38 acute myocardial infarction 10.2
39 heparin-induced thrombocytopenia 10.2
40 seizure disorder 10.2
41 liver rhabdomyosarcoma 10.2 CA4 CA1
42 osteopetrosis, autosomal recessive 3 10.2 CA4 CA1
43 occlusion precerebral artery 10.2 CA4 BDNF
44 thrombophilia due to thrombin defect 10.1
45 yemenite deaf-blind hypopigmentation syndrome 10.1
46 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 10.1
47 myocardial infarction 10.1
48 migraine with aura 10.1
49 cortical blindness 10.1
50 arteriosclerosis 10.1

Comorbidity relations with Transient Global Amnesia via Phenotypic Disease Network (PDN):


Hypertension, Essential Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Transient Global Amnesia:



Diseases related to Transient Global Amnesia

Symptoms & Phenotypes for Transient Global Amnesia

Drugs & Therapeutics for Transient Global Amnesia

Drugs for Transient Global Amnesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 3
2
Dalteparin Approved Phase 3 9005-49-6
3
Argatroban Approved, Investigational Phase 3 74863-84-6 152951
4 Antithrombins Phase 3
5 Fibrinolytic Agents Phase 3
6 Antithrombin III Phase 3
7 Serine Proteinase Inhibitors Phase 3
8
protease inhibitors Phase 3
9 Heparin, Low-Molecular-Weight Phase 3
10 Platelet Aggregation Inhibitors Phase 3
11 HIV Protease Inhibitors Phase 3
12 Anticoagulants Phase 3
13
Serine Investigational, Nutraceutical Phase 3 56-45-1 5951

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-Label, Randomised, Active Controlled, Multi-Centre Phase 3 Study to Evaluate the Safety and Efficacy of Danaparoid vs Argatroban in Treatment of Subjects With Acute HIT (HITSOVA Study) Active, not recruiting NCT03809481 Phase 3 Danaparoid Sodium;Argatroban
2 Reversible Cerebral Vasoconstriction Syndrome With Concomitant Transient Global Amnesia : a Serie of 3 Cases Report Completed NCT03739008
3 Transient Global Amnesia (TGA) Exploratory Study of the Default Mode Network in Resting State Functional MRI (fMRI) During the Acute Phase Completed NCT02010853
4 Perioperative Changes of Cognitive Function According to Jugular Vein Insufficiency in Robot-assisted Prostatectomy Completed NCT01905488
5 Neuropsycholgy and Neuroimaging in Transient Global Amnesia Terminated NCT02562560
6 Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia Terminated NCT02796287

Search NIH Clinical Center for Transient Global Amnesia

Cochrane evidence based reviews: amnesia, transient global

Genetic Tests for Transient Global Amnesia

Anatomical Context for Transient Global Amnesia

MalaCards organs/tissues related to Transient Global Amnesia:

40
Brain, Temporal Lobe, Heart, Cortex, Testes, Pituitary, Bone Marrow

Publications for Transient Global Amnesia

Articles related to Transient Global Amnesia:

(show top 50) (show all 926)
# Title Authors PMID Year
1
Transient global amnesia. 52 61
26646345 2015
2
Transient global amnesia. 52 61
25659242 2015
3
Transient global amnesia following carotid artery stenting: A case report. 61
32528605 2020
4
Recurrent transient global amnesia after intracavernous Caverject injection in erectile dysfunction after robotic prostatectomy. 61
32280597 2020
5
A multicenter study of transient global amnesia for the better detection of magnetic resonance imaging abnormalities. 61
32558010 2020
6
Shedding light on the clinical recognition process of transient global amnesia. 61
32484252 2020
7
Diffusion-weighted MRI in transient global amnesia and its diagnostic implications. 61
32532848 2020
8
Acute amnestic syndromes. 61
32203745 2020
9
Any Recent Stressors?-A Memoir of Transient Global Amnesia. 61
32478803 2020
10
Serum cortisol levels in patients with a transient global amnesia. 61
31987629 2020
11
For how long is memory lost in transient global amnesia? 61
32096297 2020
12
Structural Connectivity and Cortical Thickness Alterations in Transient Global Amnesia. 61
32381542 2020
13
SREDA: A Rare but Confusing Benign EEG Variant. 61
31393275 2020
14
Time trends, frequency, characteristics and prognosis of short-duration transient global amnesia. 61
32012408 2020
15
Long-term risk of depression after transient global amnesia: A population-based study. 61
32333492 2020
16
Transient global amnesia following transoesophageal echocardiography. 61
32350056 2020
17
Factors determining recurrence in transient global amnesia. 61
32143587 2020
18
Positive Magnetic Resonance Imaging Evidence of Transient Global Amnesia Following the Use of Sildenafil. 61
32106140 2020
19
What remains after transient global amnesia (TGA)? An ultra-high field 7 T magnetic resonance imaging study of the hippocampus. 61
31573112 2020
20
Concomitant reversible cerebral vasoconstriction syndrome and transient global amnesia. 61
31650256 2020
21
Transient global amnesia with bilateral hippocampal lesions: report of two cases. 61
31925753 2020
22
Interaction between the heart and the brain in transient global amnesia. 61
31506826 2019
23
Emergency department visits for transient global amnesia alone or in association with substance abuse. 61
31625306 2019
24
[A case of recurrent transient global amnesia showing different symptom duration and MRI findings]. 61
31474643 2019
25
Long-Term Risk of Stroke After Transient Global Amnesia in Two Prospective Cohorts. 61
31284848 2019
26
Gadolinium leakage in ocular structures: A novel MRI finding in transient global amnesia. 61
31330456 2019
27
Transient Global Amnesia in a 60-year-old female with Post-traumatic Stress Disorder. 61
31728239 2019
28
Transient hippocampal CA1 lesions in humans impair pattern separation performance. 61
30706576 2019
29
Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled. 61
31303492 2019
30
Myocardial injury in transient global amnesia: a case-control study. 61
30706590 2019
31
Recurrent transient global amnesia associated with internal jugular vein thrombosis. 61
31128457 2019
32
Impaired Smooth Pursuit During Transient Global Amnesia. 61
31286700 2019
33
Transient global amnesia and transient cortical blindness secondary to contrast induced encephalopathy after renal artery angiography. 61
30929878 2019
34
Tissue Level Mechanical Properties and Extracellular Matrix Investigation of the Bovine Jugular Venous Valve Tissue. 61
31091689 2019
35
Sex Differences in Presentation and Outcome After an Acute Transient or Minor Neurologic Event. 61
31114842 2019
36
Transient Global Amnesia in a Patient with Pituitary Adenoma: Causal or Chance Association? 61
31572159 2019
37
Optimization of magnetic resonance imaging protocol for the diagnosis of transient global amnesia. 61
31210688 2019
38
Abnormal EEG Power Spectra in Acute Transient Global Amnesia: A Quantitative EEG Study. 61
29877098 2019
39
Transient Global Amnesia Secondary to Atherosclerotic Stenosis of Accessory Posterior Cerebral Artery. 61
30709618 2019
40
Transient global amnesia associated with sildenafil use. Report of one case. 61
31344218 2019
41
The Risk of Takotsubo Cardiomyopathy in Acute Neurological Disease. 61
30094686 2019
42
An Atypical Case of Takotsubo Cardiomyopathy and Transient Global Amnesia. 61
32159080 2019
43
Strong Association Between Migraine and Transient Global Amnesia: A National Inpatient Sample Analysis. 61
30305003 2019
44
Transient global amnesia: clinical features and prognostic factors suggesting recurrence. 61
30758436 2019
45
Transient global amnesia. Have you considered hyperhomocysteinemia? 61
31664355 2019
46
Resting-state connectivity alterations during transient global amnesia. 61
31153000 2019
47
Seasonal variations in the occurrence of transient global amnesia (TGA). 61
31162624 2019
48
Transient global amnesia: an intriguing yet benign disturbance. 61
30758435 2019
49
Enhanced cortisol secretion in acute transient global amnesia. 61
30193207 2019
50
Vertebral artery loop in a case of recurrent transient global amnesia. 61
30504067 2019

Variations for Transient Global Amnesia

Expression for Transient Global Amnesia

Search GEO for disease gene expression data for Transient Global Amnesia.

Pathways for Transient Global Amnesia

Pathways related to Transient Global Amnesia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.78 PDE5A PDE11A
2
Show member pathways
10.5 CA4 CA1
3
Show member pathways
10.09 CA4 CA1

GO Terms for Transient Global Amnesia

Biological processes related to Transient Global Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bicarbonate transport GO:0015701 8.96 CA4 CA1
2 one-carbon metabolic process GO:0006730 8.62 CA4 CA1

Molecular functions related to Transient Global Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.25 RPA1 PPM1E PDE5A PDE11A PCLO METTL18
2 metal ion binding GO:0046872 9.61 RPA1 PPM1E PDE5A PDE11A PCLO KLF6
3 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114 9.4 PDE5A PDE11A
4 hydro-lyase activity GO:0016836 9.37 CA4 CA1
5 3',5'-cyclic-GMP phosphodiesterase activity GO:0047555 9.32 PDE5A PDE11A
6 cGMP binding GO:0030553 9.26 PDE5A PDE11A
7 carbonate dehydratase activity GO:0004089 9.16 CA4 CA1
8 cyclic-nucleotide phosphodiesterase activity GO:0004112 8.62 PDE5A PDE11A

Sources for Transient Global Amnesia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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