MCID: TRN012
MIFTS: 39

Transient Global Amnesia

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Transient Global Amnesia

MalaCards integrated aliases for Transient Global Amnesia:

Name: Transient Global Amnesia 12 76 53 15
Amnesia, Transient Global 76 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13027
ICD10 33 G45.4
ICD9CM 35 437.7
MeSH 44 D020236
NCIt 50 C85198
UMLS 73 C0338591

Summaries for Transient Global Amnesia

NIH Rare Diseases : 53 Transient global amnesia (TGA) is a condition characterized by sudden onset of memory loss and confusion. During an episode of TGA, a person is not able to make new memories. The person may be disoriented in regard to time and place, but can remember who they are and can recognize family members. TGA typically lasts for several hours, but can last up to ten hours. Since no memories are made during a TGA episode, the person will never remember what happened during this period, but all other memory is usually intact. Most people have only one episode of TGA during their lifetime. The underlying cause of TGA is unclear. There is no specific treatment for TGA as it usually resolves on its own.

MalaCards based summary : Transient Global Amnesia, also known as amnesia, transient global, is related to aphasia and migraine with or without aura 1. An important gene associated with Transient Global Amnesia is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are TGF-beta Signaling Pathway (WikiPathways) and Spinal Cord Injury. Affiliated tissues include temporal lobe, brain and heart, and related phenotype is hematopoietic system.

Disease Ontology : 12 An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories.

Wikipedia : 76 Transient global amnesia (TGA) is a neurological disorder whose key defining characteristic is a... more...

Related Diseases for Transient Global Amnesia

Diseases related to Transient Global Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 aphasia 30.1 BDNF PRNP PSEN1
2 migraine with or without aura 1 29.7 FOS KANTR PDE5A
3 amnestic disorder 10.7
4 ischemia 10.4
5 epilepsy 10.3
6 transient cerebral ischemia 10.3
7 myocardial infarction 10.2
8 acute myocardial infarction 10.2
9 thrombocytopenia 10.2
10 thrombosis 10.2
11 retrograde amnesia 10.2
12 encephalitis 10.2
13 heparin-induced thrombocytopenia 10.2
14 psychosexual disorder 10.2 ALDH7A1 PDE5A
15 vasculogenic impotence 10.1 ALDH7A1 PDE5A
16 prosopagnosia 10.1 EP300 PSEN1
17 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 10.1
18 arteriovenous fistula 10.1
19 hydrocephalus 10.1
20 herpes simplex 10.1
21 head injury 10.1
22 alveolar periostitis 10.1 KANTR MBL2
23 alexia 10.1 KANTR PSEN1
24 trigeminal nerve neoplasm 10.1 CRLF1 KANTR
25 neurilemmoma of the fifth cranial nerve 10.0 CRLF1 KANTR
26 glossopharyngeal neuralgia 10.0 CRLF1 KANTR
27 central nervous system disease 10.0 BDNF PRNP PSEN1
28 visual agnosia 10.0 KANTR PSEN1
29 apnea, obstructive sleep 9.9
30 cardiac arrhythmia 9.9
31 cardiac conduction defect 9.9
32 multiple sclerosis 9.9
33 sneddon syndrome 9.9
34 thrombophilia due to thrombin defect 9.9
35 stroke, ischemic 9.9
36 epilepsy, juvenile absence 1 9.9
37 b-cell lymphomas 9.9
38 diabetes mellitus 9.9
39 nephrolithiasis 9.9
40 temporal lobe epilepsy 9.9
41 segmental dystonia 9.9
42 sleep apnea 9.9
43 lymphoma 9.9
44 juvenile absence epilepsy 9.9
45 heart disease 9.9
46 cortical blindness 9.9
47 dementia 9.9
48 patent foramen ovale 9.9
49 obstructive hydrocephalus 9.9
50 antiphospholipid syndrome 9.9

Comorbidity relations with Transient Global Amnesia via Phenotypic Disease Network (PDN):


Hypertension, Essential Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Transient Global Amnesia:



Diseases related to Transient Global Amnesia

Symptoms & Phenotypes for Transient Global Amnesia

MGI Mouse Phenotypes related to Transient Global Amnesia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.28 CRLF1 EP300 FOS KLF6 MBL2 PRNP

Drugs & Therapeutics for Transient Global Amnesia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Reversible Cerebral Vasoconstriction Syndrome With Concomitant Transient Global Amnesia Completed NCT03739008
2 Transient Global Amnesia (TGA). Exploratory Study of the Default Mode Network During the Acute Phase Completed NCT02010853 Not Applicable
3 Perioperative Changes of Cognitive Function According to Jugular Vein Insufficiency in Robot-assisted Prostatectomy Completed NCT01905488
4 Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia Recruiting NCT02796287 Not Applicable
5 Neuropsycholgy and Neuroimaging in Transient Global Amnesia Terminated NCT02562560 Not Applicable

Search NIH Clinical Center for Transient Global Amnesia

Cochrane evidence based reviews: amnesia, transient global

Genetic Tests for Transient Global Amnesia

Anatomical Context for Transient Global Amnesia

MalaCards organs/tissues related to Transient Global Amnesia:

41
Temporal Lobe, Brain, Heart, Cortex, Testes, Pituitary, B Cells

Publications for Transient Global Amnesia

Articles related to Transient Global Amnesia:

(show top 50) (show all 616)
# Title Authors Year
1
Enhanced cortisol secretion in acute transient global amnesia. ( 30193207 )
2019
2
Tako-tsubo cardiomyopathy with transient global amnesia and cerebellar embolic stroke triggered by existential fear. ( 29720346 )
2018
3
Transient global amnesia presenting in primary care: A case report. ( 29927811 )
2018
4
Subarachnoid hemorrhage after transient global amnesia caused by cerebral venous congestion: case report. ( 29625555 )
2018
5
Teaching NeuroImages: Convexal subarachnoid hemorrhage accompanied by transient global amnesia. ( 29784726 )
2018
6
Serial Diffusion-Weighted Imaging in Transient Global Amnesia? ( 29456367 )
2018
7
Abnormal EEG Power Spectra in Acute Transient Global Amnesia: A Quantitative EEG Study. ( 29877098 )
2018
8
Transient global amnesia: Diffusion MRI findings. ( 29692518 )
2018
9
Relationship between Cytotoxicity in the Hippocampus and an Abnormal High Intensity Area on the Diffusion-weighted Images of Three Patients with Transient Global Amnesia. ( 29709925 )
2018
10
Dural Arteriovenous Fistula Causing Recurrent Transient Global Amnesia. ( 30245773 )
2018
11
Juvenile absence epilepsy relapsing as recurrent absence status, mimicking transient global amnesia, in an elderly patient. ( 30530409 )
2018
12
Temporary Memory Steal: Transient Global Amnesia Secondary to Nephrolithiasis. ( 30443620 )
2018
13
Transient global amnesia: Minor inconvenience or early warning sign? ( 30069134 )
2018
14
Concomitant transient global amnesia and takotsubo cardiomyopathy following a stressful event. ( 30094523 )
2018
15
Clinics in diagnostic imaging (188). Transient global amnesia (TGA). ( 30109353 )
2018
16
Some thoughts about concomitant transient global amnesia and takotsubo syndrome. ( 30151690 )
2018
17
Medical Procedure-Related Transient Global Amnesia. ( 30205365 )
2018
18
Strong Association Between Migraine and Transient Global Amnesia: A National Inpatient Sample Analysis. ( 30305003 )
2018
19
Risk factors of transient global amnesia: Three case reports. ( 30313071 )
2018
20
Vertebral artery loop in a case of recurrent transient global amnesia. ( 30504067 )
2018
21
A case of recurrent transient global amnesia: don't forget the hippocampal punctuate diffusion restriction. ( 29977579 )
2018
22
Long-term sequelae of hippocampal lesions in patients with transient global amnesia: A multiparametric MRI study. ( 28884957 )
2017
23
Comprehensive Ultrasound Assessment of the Craniocervical Circulation in Transient Global Amnesia. ( 28850691 )
2017
24
"Once again she forgets everything!": a patient with four episodes of transient global amnesia within less than 5A years. ( 28942504 )
2017
25
A case of thalamo-mesencephalon infarct presenting as transient global amnesia: do we overlook the diagnosis? ( 28083760 )
2017
26
A Case of Transient Global Amnesia with Small Left Putamen Infarction. ( 27863873 )
2017
27
Decreased Metabolism in the Posterior Medial Network with Concomitantly Increased Metabolism in the Anterior Temporal Network During Transient Global Amnesia. ( 29038979 )
2017
28
Transient global amnesia following a whole-body cryotherapy session. ( 29030365 )
2017
29
Cortical morphology in patients with transient global amnesia. ( 29299390 )
2017
30
Incidental Hippocampal Hyperintensity on Diffusion-weighted MRI: Individual Susceptibility to Transient Global Amnesia. ( 28644249 )
2017
31
Transient global amnesia: The cerebral Takotsubo? ( 28431611 )
2017
32
Repetitive Questioning and Writing in a Patient with Transient Global Amnesia. ( 29057635 )
2017
33
Transient Global Amnesia ( 28723030 )
2017
34
Seasonal Variation in the Incidence of Transient Global Amnesia in South Korea. ( 28831787 )
2017
35
Prevalence of obstructive sleep apnea syndrome in a population of patients with transient global amnesia. ( 28366339 )
2017
36
Transient Global Amnesia: Commentary on Trip Gabriel's First-Person Account. ( 28323680 )
2017
37
Transient global amnesia in immediate postoperative period: A diagnostic dilemma. ( 28235512 )
2017
38
Vascular Risk Factors and Internal Jugular Venous Flow in Transient Global Amnesia: A Study of 165 Japanese Patients. ( 28669658 )
2017
39
Transient global amnesia. ( 28936081 )
2017
40
Simultaneous transient global amnesia and right MCA stroke after Valsalva manoeuvre. ( 28433970 )
2017
41
Transient global amnesia: current perspectives. ( 29123402 )
2017
42
Transient global amnesia: clinical and imaging features. ( 29024985 )
2017
43
The Day That Went Missing: A First-Person Account of Transient Global Amnesia. ( 28323679 )
2017
44
Long-Term Outcome in Patients With Transient Global Amnesia: A Population-Based Study. ( 28185658 )
2017
45
Reversible Cerebral Vasoconstriction Syndrome Presenting with Transient Global Amnesia. ( 28626186 )
2017
46
Isolated punctuate hippocampal infarction and transient global amnesia are indistinguishable by means of MRI. ( 28112030 )
2017
47
Takotsubo cardiomyopathy and transient global amnesia: a shared aetiology. ( 28710234 )
2017
48
Posterior hippocampal stroke presenting with transient global amnesia. ( 28004602 )
2016
49
Transient Global Amnesia Deteriorates the Network Efficiency of the Theta Band. ( 27741293 )
2016
50
Transient global amnesia: emergency department evaluation and management [digest]. ( 28745847 )
2016

Variations for Transient Global Amnesia

Expression for Transient Global Amnesia

Search GEO for disease gene expression data for Transient Global Amnesia.

Pathways for Transient Global Amnesia

Pathways related to Transient Global Amnesia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 EP300 FOS KLF6
2 11 BDNF FOS PRB1 SELP

GO Terms for Transient Global Amnesia

Biological processes related to Transient Global Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.5 BDNF CRLF1 PSEN1
2 response to oxidative stress GO:0006979 9.33 MBL2 PRNP PSEN1
3 calcium-mediated signaling using intracellular calcium source GO:0035584 9.26 PRNP SELP
4 neuron projection maintenance GO:1990535 8.96 PRNP PSEN1
5 modulation of age-related behavioral decline GO:0090647 8.62 PRNP PSEN1

Sources for Transient Global Amnesia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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