MCID: TRN012
MIFTS: 37

Transient Global Amnesia

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Transient Global Amnesia

MalaCards integrated aliases for Transient Global Amnesia:

Name: Transient Global Amnesia 12 77 54 15
Amnesia, Transient Global 77 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13027
ICD9CM 36 437.7
MeSH 45 D020236
NCIt 51 C85198
ICD10 34 G45.4
UMLS 74 C0338591

Summaries for Transient Global Amnesia

NIH Rare Diseases : 54 Transient global amnesia (TGA) is a condition characterized by sudden onset of memory loss and confusion. During an episode of TGA, a person is not able to make new memories. The person may be disoriented in regard to time and place, but can remember who they are and can recognize family members. TGA typically lasts for several hours, but can last up to ten hours. Since no memories are made during a TGA episode, the person will never remember what happened during this period, but all other memory is usually intact. Most people have only one episode of TGA during their lifetime. The underlying cause of TGA is unclear. There is no specific treatment for TGA as it usually resolves on its own.

MalaCards based summary : Transient Global Amnesia, also known as amnesia, transient global, is related to migraine with or without aura 1 and amnestic disorder. An important gene associated with Transient Global Amnesia is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are TGF-beta Signaling Pathway (WikiPathways) and Spinal Cord Injury. Affiliated tissues include temporal lobe, brain and cortex, and related phenotype is mortality/aging.

Disease Ontology : 12 An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories.

Wikipedia : 77 Transient global amnesia (TGA) is a neurological disorder whose key defining characteristic is a... more...

Related Diseases for Transient Global Amnesia

Diseases related to Transient Global Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 migraine with or without aura 1 29.5 FOS KANTR PDE5A
2 amnestic disorder 10.7
3 ischemia 10.5
4 epilepsy 10.3
5 transient cerebral ischemia 10.3
6 broken heart syndrome 10.3
7 psychosexual disorder 10.2 ALDH7A1 PDE5A
8 myocardial infarction 10.2
9 acute myocardial infarction 10.2
10 thrombocytopenia 10.2
11 thrombosis 10.2
12 retrograde amnesia 10.2
13 encephalitis 10.2
14 heparin-induced thrombocytopenia 10.2
15 vasculogenic impotence 10.2 ALDH7A1 PDE5A
16 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 10.1
17 arteriovenous fistula 10.1
18 hydrocephalus 10.1
19 aphasia 10.1
20 herpes simplex 10.1
21 encephalopathy 10.1
22 head injury 10.1
23 alveolar periostitis 10.0 KANTR MBL2
24 trigeminal nerve neoplasm 10.0 CRLF1 KANTR
25 neurilemmoma of the fifth cranial nerve 10.0 CRLF1 KANTR
26 glossopharyngeal neuralgia 10.0 CRLF1 KANTR
27 apnea, obstructive sleep 10.0
28 atrial standstill 1 10.0
29 cardiac arrhythmia 10.0
30 cardiac conduction defect 10.0
31 multiple sclerosis 10.0
32 sneddon syndrome 10.0
33 thrombophilia due to thrombin defect 10.0
34 stroke, ischemic 10.0
35 neuronal intranuclear inclusion disease 10.0
36 epilepsy, juvenile absence 1 10.0
37 hemorrhage, intracerebral 10.0
38 b-cell lymphomas 10.0
39 diabetes mellitus 10.0
40 nephrolithiasis 10.0
41 temporal lobe epilepsy 10.0
42 segmental dystonia 10.0
43 sleep apnea 10.0
44 lymphoma 10.0
45 juvenile absence epilepsy 10.0
46 heart disease 10.0
47 cortical blindness 10.0
48 dementia 10.0
49 patent foramen ovale 10.0
50 obstructive hydrocephalus 10.0

Comorbidity relations with Transient Global Amnesia via Phenotypic Disease Network (PDN):


Hypertension, Essential Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Transient Global Amnesia:



Diseases related to Transient Global Amnesia

Symptoms & Phenotypes for Transient Global Amnesia

MGI Mouse Phenotypes related to Transient Global Amnesia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.32 BDNF CRLF1 EP300 FOS GLA KLF6

Drugs & Therapeutics for Transient Global Amnesia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Reversible Cerebral Vasoconstriction Syndrome With Concomitant Transient Global Amnesia Completed NCT03739008
2 Transient Global Amnesia (TGA). Exploratory Study of the Default Mode Network During the Acute Phase Completed NCT02010853 Not Applicable
3 Perioperative Changes of Cognitive Function According to Jugular Vein Insufficiency in Robot-assisted Prostatectomy Completed NCT01905488
4 Neuropsycholgy and Neuroimaging in Transient Global Amnesia Terminated NCT02562560 Not Applicable
5 Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia Terminated NCT02796287 Not Applicable

Search NIH Clinical Center for Transient Global Amnesia

Cochrane evidence based reviews: amnesia, transient global

Genetic Tests for Transient Global Amnesia

Anatomical Context for Transient Global Amnesia

MalaCards organs/tissues related to Transient Global Amnesia:

42
Temporal Lobe, Brain, Cortex, Testes, Pituitary, B Cells, Prefrontal Cortex

Publications for Transient Global Amnesia

Articles related to Transient Global Amnesia:

(show top 50) (show all 627)
# Title Authors Year
1
Enhanced cortisol secretion in acute transient global amnesia. ( 30193207 )
2019
2
Strong Association Between Migraine and Transient Global Amnesia: A National Inpatient Sample Analysis. ( 30305003 )
2019
3
Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report. ( 30678717 )
2019
4
Myocardial injury in Transient Global Amnesia: a case-control study. ( 30706590 )
2019
5
Transient Global Amnesia Secondary to Atherosclerotic Stenosis of Accessory Posterior Cerebral Artery. ( 30709618 )
2019
6
Transient global amnesia: an intriguing yet benign disturbance. ( 30758435 )
2019
7
Transient global amnesia: clinical features and prognostic factors suggesting recurrence. ( 30758436 )
2019
8
Transient Global Amnesia Linked to Impairment of Brain Venous Drainage: An Ultrasound Investigation. ( 30804883 )
2019
9
Transient Global Amnesia as the Sole Presentation of an Acute Stroke in the Left Cingulate Gyrus. ( 30915247 )
2019
10
Tako-tsubo cardiomyopathy with transient global amnesia and cerebellar embolic stroke triggered by existential fear. ( 29720346 )
2018
11
Transient global amnesia presenting in primary care: A case report. ( 29927811 )
2018
12
Subarachnoid hemorrhage after transient global amnesia caused by cerebral venous congestion: case report. ( 29625555 )
2018
13
Teaching NeuroImages: Convexal subarachnoid hemorrhage accompanied by transient global amnesia. ( 29784726 )
2018
14
Serial Diffusion-Weighted Imaging in Transient Global Amnesia? ( 29456367 )
2018
15
Abnormal EEG Power Spectra in Acute Transient Global Amnesia: A Quantitative EEG Study. ( 29877098 )
2018
16
Transient global amnesia: Diffusion MRI findings. ( 29692518 )
2018
17
Relationship between Cytotoxicity in the Hippocampus and an Abnormal High Intensity Area on the Diffusion-weighted Images of Three Patients with Transient Global Amnesia. ( 29709925 )
2018
18
A case of recurrent transient global amnesia: don't forget the hippocampal punctuate diffusion restriction. ( 29977579 )
2018
19
Dural Arteriovenous Fistula Causing Recurrent Transient Global Amnesia. ( 30245773 )
2018
20
A Case of Posterior Reversible Encephalopathy Syndrome with Similar Symptoms as Transient Global Amnesia. ( 30906408 )
2018
21
Juvenile absence epilepsy relapsing as recurrent absence status, mimicking transient global amnesia, in an elderly patient. ( 30530409 )
2018
22
Temporary Memory Steal: Transient Global Amnesia Secondary to Nephrolithiasis. ( 30443620 )
2018
23
Transient global amnesia: Minor inconvenience or early warning sign? ( 30069134 )
2018
24
Concomitant transient global amnesia and takotsubo cardiomyopathy following a stressful event. ( 30094523 )
2018
25
Clinics in diagnostic imaging (188). Transient global amnesia (TGA). ( 30109353 )
2018
26
Some thoughts about concomitant transient global amnesia and takotsubo syndrome. ( 30151690 )
2018
27
Medical Procedure-Related Transient Global Amnesia. ( 30205365 )
2018
28
Risk factors of transient global amnesia: Three case reports. ( 30313071 )
2018
29
Vertebral artery loop in a case of recurrent transient global amnesia. ( 30504067 )
2018
30
Long-term sequelae of hippocampal lesions in patients with transient global amnesia: A multiparametric MRI study. ( 28884957 )
2017
31
Comprehensive Ultrasound Assessment of the Craniocervical Circulation in Transient Global Amnesia. ( 28850691 )
2017
32
"Once again she forgets everything!": a patient with four episodes of transient global amnesia within less than 5A years. ( 28942504 )
2017
33
A case of thalamo-mesencephalon infarct presenting as transient global amnesia: do we overlook the diagnosis? ( 28083760 )
2017
34
A Case of Transient Global Amnesia with Small Left Putamen Infarction. ( 27863873 )
2017
35
Decreased Metabolism in the Posterior Medial Network with Concomitantly Increased Metabolism in the Anterior Temporal Network During Transient Global Amnesia. ( 29038979 )
2017
36
Transient global amnesia following a whole-body cryotherapy session. ( 29030365 )
2017
37
Cortical morphology in patients with transient global amnesia. ( 29299390 )
2017
38
Incidental Hippocampal Hyperintensity on Diffusion-weighted MRI: Individual Susceptibility to Transient Global Amnesia. ( 28644249 )
2017
39
Transient global amnesia: The cerebral Takotsubo? ( 28431611 )
2017
40
Repetitive Questioning and Writing in a Patient with Transient Global Amnesia. ( 29057635 )
2017
41
Transient Global Amnesia ( 28723030 )
2017
42
Seasonal Variation in the Incidence of Transient Global Amnesia in South Korea. ( 28831787 )
2017
43
Prevalence of obstructive sleep apnea syndrome in a population of patients with transient global amnesia. ( 28366339 )
2017
44
Transient Global Amnesia: Commentary on Trip Gabriel's First-Person Account. ( 28323680 )
2017
45
Transient global amnesia in immediate postoperative period: A diagnostic dilemma. ( 28235512 )
2017
46
Vascular Risk Factors and Internal Jugular Venous Flow in Transient Global Amnesia: A Study of 165 Japanese Patients. ( 28669658 )
2017
47
Transient global amnesia. ( 28936081 )
2017
48
Simultaneous transient global amnesia and right MCA stroke after Valsalva manoeuvre. ( 28433970 )
2017
49
Transient global amnesia: current perspectives. ( 29123402 )
2017
50
Transient global amnesia: clinical and imaging features. ( 29024985 )
2017

Variations for Transient Global Amnesia

Expression for Transient Global Amnesia

Search GEO for disease gene expression data for Transient Global Amnesia.

Pathways for Transient Global Amnesia

Pathways related to Transient Global Amnesia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 EP300 FOS KLF6
2 11 BDNF FOS PRB1 SELP

GO Terms for Transient Global Amnesia

Biological processes related to Transient Global Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium-mediated signaling using intracellular calcium source GO:0035584 8.62 PRNP SELP

Sources for Transient Global Amnesia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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