MCID: TRN016
MIFTS: 37

Transient Hypogammaglobulinemia

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Transient Hypogammaglobulinemia

MalaCards integrated aliases for Transient Hypogammaglobulinemia:

Name: Transient Hypogammaglobulinemia 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:625
NCIt 51 C27319
UMLS 74 C0859960

Summaries for Transient Hypogammaglobulinemia

MalaCards based summary : Transient Hypogammaglobulinemia is related to transient hypogammaglobulinemia of infancy and microcephaly with chemotactic defect and transient hypogammaglobulinemia. An important gene associated with Transient Hypogammaglobulinemia is CD19 (CD19 Molecule), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include b cells and t cells, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Transient Hypogammaglobulinemia

Diseases in the Transient Hypogammaglobulinemia family:

Congenital Hypogammaglobulinemia Transient Hypogammaglobulinemia of Infancy

Diseases related to Transient Hypogammaglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 transient hypogammaglobulinemia of infancy 32.8 CD19 IL10 LTA TGFBR1 TGFBR2
2 microcephaly with chemotactic defect and transient hypogammaglobulinemia 12.3
3 say barber miller syndrome 11.3
4 encephalitozoonosis 10.2 CD19 TNF
5 posterior scleritis 10.2 CD19 TNF
6 diffuse infiltrative lymphocytosis syndrome 10.2 CD19 TNF
7 streptococcal toxic-shock syndrome 10.1 LTA TNF
8 null-cell leukemia 10.1 LTA TNF
9 listeria meningitis 10.1 LTA TNF
10 sympathetic ophthalmia 10.1 LTA TNF
11 shigellosis 10.1 IL10 LTA
12 spondylarthropathy 10.1 LTA TNF
13 punctate inner choroidopathy 10.1 IL10 TNF
14 tropical endomyocardial fibrosis 10.1 IL10 TNF
15 endomyocardial fibrosis 10.1 IL10 TNF
16 multifocal choroiditis 10.1 IL10 TNF
17 choroiditis 10.1 IL10 TNF
18 tungiasis 10.1 IL10 TNF
19 dermatitis, atopic 10.1
20 immunoglobulin alpha deficiency 10.1
21 dermatitis 10.1
22 cow milk allergy 10.1 IL10 TNF
23 acute respiratory distress syndrome 10.1 LTA TNF
24 trichuriasis 10.1 IL10 TNF
25 mucocutaneous leishmaniasis 10.1 IL10 TNF
26 cutaneous leishmaniasis 10.1 IL10 TNF
27 chronic graft versus host disease 10.1 IL10 TNF
28 clonorchiasis 10.1 IL10 TNF
29 trachoma 10.1 IL10 TNF
30 autoimmune gastritis 10.1 IL10 TNF
31 autoimmune disease of eyes, ear, nose and throat 10.1 IL10 TNF
32 intermediate uveitis 10.1 IL10 TNF
33 orofacial granulomatosis 10.1 IL10 TNF
34 transverse myelitis 10.1 IL10 TNF
35 primary systemic mycosis 10.1 IL10 TNF
36 mycoplasma pneumoniae pneumonia 10.1 IL10 TNF
37 optic neuritis 10.1 LTA TNF
38 multidrug-resistant tuberculosis 10.1 IL10 TNF
39 poliomyelitis 10.1 IL10 TNF
40 eales disease 10.1 IL10 TNF
41 hemorrhagic fever 10.1 IL10 TNF
42 immune deficiency disease 10.1 CD19 IL10
43 spotted fever 10.1 IL10 TNF
44 coccidiosis 10.1 IL10 TNF
45 hematopoietic stem cell transplantation 10.1 IL10 TNF
46 aseptic meningitis 10.1 IL10 TNF
47 scrub typhus 10.1 IL10 TNF
48 panuveitis 10.1 IL10 TNF
49 plasmodium vivax malaria 10.1 IL10 TNF
50 bacterial sepsis 10.1 IL10 TNF

Graphical network of the top 20 diseases related to Transient Hypogammaglobulinemia:



Diseases related to Transient Hypogammaglobulinemia

Symptoms & Phenotypes for Transient Hypogammaglobulinemia

MGI Mouse Phenotypes related to Transient Hypogammaglobulinemia:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10 CD19 IL10 LTA TGFBR1 TGFBR2 TNF
2 growth/size/body region MP:0005378 9.95 CD19 IL10 LTA TGFBR1 TGFBR2 TNF
3 hematopoietic system MP:0005397 9.93 CD19 IL10 LTA TGFBR1 TGFBR2 TNF
4 digestive/alimentary MP:0005381 9.91 CD19 IL10 TGFBR1 TGFBR2 TNF
5 homeostasis/metabolism MP:0005376 9.91 CD19 IL10 LTA TGFBR1 TGFBR2 TNF
6 endocrine/exocrine gland MP:0005379 9.89 IL10 LTA TGFBR1 TGFBR2 TNF
7 immune system MP:0005387 9.88 CD19 IL10 LTA TGFBR1 TGFBR2 TNF
8 mortality/aging MP:0010768 9.8 CD19 IL10 LTA TGFBR1 TGFBR2 TNF
9 liver/biliary system MP:0005370 9.77 CD19 IL10 LTA TGFBR2 TNF
10 neoplasm MP:0002006 9.65 CD19 IL10 TGFBR1 TGFBR2 TNF
11 nervous system MP:0003631 9.63 CD19 IL10 LTA TGFBR1 TGFBR2 TNF
12 respiratory system MP:0005388 9.35 IL10 LTA TGFBR1 TGFBR2 TNF
13 skeleton MP:0005390 9.02 IL10 LTA TGFBR1 TGFBR2 TNF

Drugs & Therapeutics for Transient Hypogammaglobulinemia

Search Clinical Trials , NIH Clinical Center for Transient Hypogammaglobulinemia

Genetic Tests for Transient Hypogammaglobulinemia

Anatomical Context for Transient Hypogammaglobulinemia

MalaCards organs/tissues related to Transient Hypogammaglobulinemia:

42
B Cells, T Cells

Publications for Transient Hypogammaglobulinemia

Articles related to Transient Hypogammaglobulinemia:

(show all 48)
# Title Authors Year
1
B lymphocyte subsets and outcomes in patients with an initial diagnosis of transient hypogammaglobulinemia of infancy. ( 30152873 )
2018
2
Transient hypogammaglobulinemia and severe atopic dermatitis: Open-label treatment with immunoglobulin in a case series. ( 27470901 )
2016
3
Transient hypogammaglobulinemia of infancy: predictive factors for late recovery. ( 27735798 )
2015
4
FcI^ receptor polymorphisms in patients with transient hypogammaglobulinemia of infancy presenting with mild and severe infections. ( 26708396 )
2015
5
Severe atopic dermatitis associated with transient hypogammaglobulinemia of infancy. ( 25600656 )
2015
6
Decreased IgM, IgA, and IgG response to pneumococcal vaccine in children with transient hypogammaglobulinemia of infancy. ( 26233927 )
2015
7
Does intravenous immunoglobulin therapy prolong immunodeficiency in transient hypogammaglobulinemia of infancy? ( 24198926 )
2013
8
The elevated number of circulating regulatory T cells in patients with transient hypogammaglobulinemia of infancy is not associated with any abnormalities in the genes encoding the TGF-I^ receptors. ( 23899993 )
2013
9
B-cell subsets in patients with transient hypogammaglobulinemia of infancy, partial IgA deficiency, and selective IgM deficiency. ( 23654075 )
2013
10
Reduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancy. ( 22820757 )
2013
11
Severe atopic dermatitis and transient hypogammaglobulinemia in children. ( 21854413 )
2012
12
The efficacy of Pelargonium sidoides in the treatment of upper respiratory tract infections in children with transient hypogammaglobulinemia of infancy. ( 22809962 )
2012
13
BCGitis in a Patient with Transient Hypogammaglobulinemia of Infancy. ( 23253103 )
2012
14
The number of circulating CD4+ CD25high Foxp3+ T lymphocytes is transiently elevated in the early childhood of transient hypogammaglobulinemia of infancy patients. ( 21531630 )
2011
15
New laboratory findings in Turkish patients with transient hypogammaglobulinemia of infancy. ( 21131704 )
2010
16
Transient hypogammaglobulinemia of infancy: intravenous immunoglobulin as first line therapy. ( 20378022 )
2010
17
Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: 'similarities and differences'. ( 20609138 )
2010
18
Massive empyema associated with transient hypogammaglobulinemia of infancy and IgA deficiency. ( 19399287 )
2009
19
A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: results from the Italian Primary Immunodeficiency Network. ( 18547478 )
2008
20
Atopic dermatitis and transient hypogammaglobulinemia of infancy improved simultaneously. ( 17532847 )
2007
21
Transient hypogammaglobulinemia after antiepileptic drug hypersensitivity. ( 17509469 )
2007
22
Impaired specific antibody response and increased B-cell population in transient hypogammaglobulinemia of infancy. ( 17165264 )
2006
23
Transient hypogammaglobulinemia of infancy presenting as Staphylococcus aureus sepsis with deep neck infection. ( 15843860 )
2005
24
Immunoglobulin G2 deficiency with transient hypogammaglobulinemia and chronic respiratory disease in a 6-month-old Holstein heifer. ( 15460327 )
2004
25
Transient hypogammaglobulinemia of infancy and early childhood: outcome of 30 cases. ( 15214739 )
2004
26
Polio vaccine virus-associated meningoencephalitis in an infant with transient hypogammaglobulinemia. ( 11525363 )
2001
27
Case of transient erythroblastopenia of childhood with transient hypogammaglobulinemia. ( 10804733 )
2000
28
Transient hypogammaglobulinemia of infancy: clinical and immunologic features of 40 new cases. ( 11192522 )
2000
29
Transient hypogammaglobulinemia in a Simmental heifer. ( 9503361 )
1998
30
Cytokine production in transient hypogammaglobulinemia and isolated IgA deficiency. ( 9338552 )
1997
31
X-linked agammaglobulinemia presenting as transient hypogammaglobulinemia of infancy. ( 7722175 )
1995
32
"Bronchitis" obliterans and prolonged transient hypogammaglobulinemia in a child. ( 8134161 )
1993
33
Absent specific viral antibodies in patients with transient hypogammaglobulinemia of infancy. ( 2303650 )
1990
34
Transient hypogammaglobulinemia of infancy. ( 2264470 )
1990
35
Two relapses of group B streptococcal sepsis and transient hypogammaglobulinemia. ( 2682506 )
1989
36
Transient hypogammaglobulinemia of infancy: Five new cases, review of the literature and redefinition. ( 2596283 )
1989
37
Transient hypogammaglobulinemia of infancy: need to reconsider name and definition. ( 3794886 )
1987
38
Streptococcal sepsis presenting as acute abdomen in a child with transient hypogammaglobulinemia of infancy. ( 3540263 )
1986
39
Transient hypogammaglobulinemia of infancy with severe bacterial infections and persistent IgA deficiency. ( 2427477 )
1986
40
Is transient hypogammaglobulinemia of infancy a manifestation of zinc deficiency? ( 6233190 )
1984
41
Transient hypogammaglobulinemia in the adult. Functional assessment of T and B lymphocytes. ( 6603517 )
1983
42
Transient hypogammaglobulinemia of infancy. ( 6977720 )
1982
43
Anhidrotic ectodermal dysplasia with transient hypogammaglobulinemia. ( 7307559 )
1981
44
Deficiency of T helper cells in transient hypogammaglobulinemia of infancy. ( 6270560 )
1981
45
Transient hypogammaglobulinemia, elevated immunoglobulin E levels, and food allergy. ( 89129 )
1979
46
Transient hypogammaglobulinemia of infancy: review of the literature, clinical and immunologic features of 11 new cases, and long-term follow-up. ( 632973 )
1978
47
Transient hypogammaglobulinemia of infancy. ( 75969 )
1978
48
Transient hypogammaglobulinemia of infancy. ( 908979 )
1977

Variations for Transient Hypogammaglobulinemia

Expression for Transient Hypogammaglobulinemia

Search GEO for disease gene expression data for Transient Hypogammaglobulinemia.

Pathways for Transient Hypogammaglobulinemia

Pathways related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.55 IL10 LTA TGFBR1 TGFBR2 TNF
2
Show member pathways
13.37 IL10 LTA TGFBR1 TGFBR2 TNF
3
Show member pathways
13.21 IL10 LTA TGFBR1 TGFBR2 TNF
4
Show member pathways
12.94 IL10 LTA TGFBR1 TGFBR2 TNF
5
Show member pathways
12.89 IL10 TGFBR1 TGFBR2 TNF
6 12.33 CD19 IL10 TNF
7
Show member pathways
12.21 IL10 TGFBR1 TGFBR2 TNF
8 11.94 TGFBR1 TGFBR2 TNF
9
Show member pathways
11.85 IL10 TGFBR1 TGFBR2
10
Show member pathways
11.85 IL10 TGFBR1 TGFBR2
11
Show member pathways
11.83 IL10 LTA TGFBR1 TNF
12 11.81 TGFBR1 TGFBR2 TNF
13 11.8 LTA TGFBR1 TGFBR2 TNF
14 11.75 CD19 IL10 TNF
15 11.67 TGFBR1 TGFBR2 TNF
16 11.59 TGFBR1 TGFBR2 TNF
17 11.51 IL10 LTA TNF
18 11.48 IL10 LTA
19 11.45 CD19 IL10 TNF
20 11.41 LTA TNF
21 11.4 CD19 IL10
22 11.38 TGFBR1 TGFBR2
23
Show member pathways
11.36 LTA TNF
24 11.35 TGFBR1 TGFBR2
25 11.34 IL10 TNF
26 11.34 IL10 TNF
27 11.3 TGFBR1 TNF
28 11.21 IL10 TNF
29 11.2 TGFBR1 TGFBR2 TNF
30 11.18 IL10 TNF
31
Show member pathways
11.14 IL10 LTA TGFBR1 TGFBR2 TNF
32 11.1 TGFBR1 TGFBR2
33 11.08 IL10 TNF
34
Show member pathways
11.04 TGFBR1 TGFBR2
35 11.02 TGFBR1 TGFBR2
36 11.01 IL10 LTA
37 10.99 TGFBR1 TGFBR2
38 10.96 IL10 LTA TNF
39 10.91 TGFBR1 TGFBR2
40 10.79 IL10 TGFBR1 TGFBR2

GO Terms for Transient Hypogammaglobulinemia

Cellular components related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 CD19 TGFBR2 TNF
2 membrane raft GO:0045121 8.8 TGFBR1 TGFBR2 TNF

Biological processes related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.84 IL10 LTA TNF
2 positive regulation of apoptotic process GO:0043065 9.81 LTA TGFBR1 TNF
3 response to drug GO:0042493 9.79 IL10 LTA TGFBR2
4 regulation of gene expression GO:0010468 9.72 IL10 TGFBR1 TGFBR2
5 positive regulation of protein kinase B signaling GO:0051897 9.69 CD19 TGFBR1 TNF
6 response to glucocorticoid GO:0051384 9.66 IL10 TNF
7 pattern specification process GO:0007389 9.65 TGFBR1 TGFBR2
8 peptidyl-threonine phosphorylation GO:0018107 9.65 TGFBR1 TGFBR2
9 humoral immune response GO:0006959 9.65 LTA TNF
10 positive regulation of smooth muscle cell proliferation GO:0048661 9.64 TGFBR2 TNF
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.64 IL10 TNF
12 positive regulation of epithelial to mesenchymal transition GO:0010718 9.63 TGFBR1 TGFBR2
13 positive regulation of interferon-gamma production GO:0032729 9.62 LTA TNF
14 ventricular septum morphogenesis GO:0060412 9.61 TGFBR1 TGFBR2
15 lens development in camera-type eye GO:0002088 9.61 TGFBR1 TGFBR2
16 negative regulation of endothelial cell proliferation GO:0001937 9.6 TGFBR1 TNF
17 embryonic cranial skeleton morphogenesis GO:0048701 9.59 TGFBR1 TGFBR2
18 negative regulation of mitotic cell cycle GO:0045930 9.58 IL10 TNF
19 negative regulation of interleukin-6 production GO:0032715 9.58 IL10 TNF
20 response to organic substance GO:0010033 9.58 IL10 TGFBR2 TNF
21 positive regulation of cytokine secretion GO:0050715 9.57 IL10 TNF
22 regulation of synapse organization GO:0050807 9.56 IL10 TNF
23 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.54 TGFBR1 TGFBR2
24 positive regulation of glial cell proliferation GO:0060252 9.52 LTA TNF
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.49 IL10 TNF
26 pathway-restricted SMAD protein phosphorylation GO:0060389 9.48 TGFBR1 TGFBR2
27 response to cholesterol GO:0070723 9.46 TGFBR1 TGFBR2
28 endothelial cell apoptotic process GO:0072577 9.43 IL10 TNF
29 negative regulation of cytokine secretion involved in immune response GO:0002740 9.37 IL10 TNF
30 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.32 TGFBR1 TGFBR2
31 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.26 LTA TNF
32 receptor biosynthetic process GO:0032800 9.16 IL10 TNF
33 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 LTA TNF
34 negative regulation of growth of symbiont in host GO:0044130 8.8 IL10 LTA TNF

Molecular functions related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 IL10 LTA TNF
2 SMAD binding GO:0046332 9.4 TGFBR1 TGFBR2
3 growth factor binding GO:0019838 9.37 TGFBR1 TGFBR2
4 tumor necrosis factor receptor binding GO:0005164 9.32 LTA TNF
5 transforming growth factor beta binding GO:0050431 9.16 TGFBR1 TGFBR2
6 transforming growth factor beta-activated receptor activity GO:0005024 8.96 TGFBR1 TGFBR2
7 transmembrane receptor protein serine/threonine kinase activity GO:0004675 8.62 TGFBR1 TGFBR2

Sources for Transient Hypogammaglobulinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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