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MCID: TRN016
MIFTS: 36

Transient Hypogammaglobulinemia

Categories: Blood diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Transient Hypogammaglobulinemia

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MalaCards integrated aliases for Transient Hypogammaglobulinemia:

Name: Transient Hypogammaglobulinemia 12 15 72

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:625
NCIt 50 C27319
UMLS 72 C0859960
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Summaries for Transient Hypogammaglobulinemia

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MalaCards based summary : Transient Hypogammaglobulinemia is related to transient hypogammaglobulinemia of infancy and poliomyelitis. An important gene associated with Transient Hypogammaglobulinemia is CD19 (CD19 Molecule), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include b cells, t cells and brain, and related phenotypes are cardiovascular system and growth/size/body region

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Related Diseases for Transient Hypogammaglobulinemia

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Diseases in the Transient Hypogammaglobulinemia family:

Congenital Hypogammaglobulinemia Transient Hypogammaglobulinemia of Infancy

Diseases related to Transient Hypogammaglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 transient hypogammaglobulinemia of infancy 32.2 TGFBR2 TGFBR1 LTA IL10 CD19
2 poliomyelitis 30.0 TNF IL10
3 immune deficiency disease 29.9 IL10 CD19
4 gastroenteritis 29.7 TNF IL10
5 common variable immunodeficiency 29.6 TNF IL10 CD19
6 rubella 29.6 TNF IL10
7 microcephaly with chemotactic defect and transient hypogammaglobulinemia 12.4
8 say barber miller syndrome 11.4
9 agammaglobulinemia 10.7
10 encephalitozoonosis 10.3 TNF CD19
11 posterior scleritis 10.3 TNF CD19
12 diffuse infiltrative lymphocytosis syndrome 10.3 TNF CD19
13 streptococcal toxic-shock syndrome 10.2 TNF LTA
14 null-cell leukemia 10.2 TNF LTA
15 listeria meningitis 10.2 TNF LTA
16 sympathetic ophthalmia 10.2 TNF LTA
17 shigellosis 10.2 LTA IL10
18 spondylarthropathy 10.2 TNF LTA
19 punctate inner choroidopathy 10.2 TNF IL10
20 tropical endomyocardial fibrosis 10.2 TNF IL10
21 endomyocardial fibrosis 10.2 TNF IL10
22 multifocal choroiditis 10.2 TNF IL10
23 choroiditis 10.2 TNF IL10
24 acute respiratory distress syndrome 10.2 TNF LTA
25 tungiasis 10.2 TNF IL10
26 cow milk allergy 10.2 TNF IL10
27 trichuriasis 10.2 TNF IL10
28 chronic graft versus host disease 10.2 TNF IL10
29 mucocutaneous leishmaniasis 10.2 TNF IL10
30 cutaneous leishmaniasis 10.2 TNF IL10
31 clonorchiasis 10.2 TNF IL10
32 trachoma 10.2 TNF IL10
33 autoimmune gastritis 10.2 TNF IL10
34 transverse myelitis 10.1 TNF IL10
35 orofacial granulomatosis 10.1 TNF IL10
36 intermediate uveitis 10.1 TNF IL10
37 autoimmune disease of eyes, ear, nose and throat 10.1 TNF IL10
38 eales disease 10.1 TNF IL10
39 multidrug-resistant tuberculosis 10.1 TNF IL10
40 mycoplasma pneumoniae pneumonia 10.1 TNF IL10
41 optic neuritis 10.1 TNF LTA
42 primary systemic mycosis 10.1 TNF IL10
43 coccidiosis 10.1 TNF IL10
44 spotted fever 10.1 TNF IL10
45 scrub typhus 10.1 TNF IL10
46 aseptic meningitis 10.1 TNF IL10
47 hematopoietic stem cell transplantation 10.1 TNF IL10
48 plasmodium vivax malaria 10.1 TNF IL10
49 dermatitis, atopic 10.1
50 immunoglobulin alpha deficiency 10.1

Graphical network of the top 20 diseases related to Transient Hypogammaglobulinemia:



Diseases related to Transient Hypogammaglobulinemia
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Symptoms & Phenotypes for Transient Hypogammaglobulinemia

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MGI Mouse Phenotypes related to Transient Hypogammaglobulinemia:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10 CD19 IL10 LTA TGFBR1 TGFBR2 TNF
2 growth/size/body region MP:0005378 9.95 CD19 IL10 LTA TGFBR1 TGFBR2 TNF
3 hematopoietic system MP:0005397 9.93 CD19 IL10 LTA TGFBR1 TGFBR2 TNF
4 digestive/alimentary MP:0005381 9.91 CD19 IL10 TGFBR1 TGFBR2 TNF
5 homeostasis/metabolism MP:0005376 9.91 CD19 IL10 LTA TGFBR1 TGFBR2 TNF
6 endocrine/exocrine gland MP:0005379 9.89 IL10 LTA TGFBR1 TGFBR2 TNF
7 immune system MP:0005387 9.88 CD19 IL10 LTA TGFBR1 TGFBR2 TNF
8 mortality/aging MP:0010768 9.8 CD19 IL10 LTA TGFBR1 TGFBR2 TNF
9 liver/biliary system MP:0005370 9.77 CD19 IL10 LTA TGFBR2 TNF
10 neoplasm MP:0002006 9.65 CD19 IL10 TGFBR1 TGFBR2 TNF
11 nervous system MP:0003631 9.63 CD19 IL10 LTA TGFBR1 TGFBR2 TNF
12 respiratory system MP:0005388 9.35 IL10 LTA TGFBR1 TGFBR2 TNF
13 skeleton MP:0005390 9.02 IL10 LTA TGFBR1 TGFBR2 TNF
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Drugs & Therapeutics for Transient Hypogammaglobulinemia

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Search Clinical Trials , NIH Clinical Center for Transient Hypogammaglobulinemia

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Genetic Tests for Transient Hypogammaglobulinemia

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Anatomical Context for Transient Hypogammaglobulinemia

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MalaCards organs/tissues related to Transient Hypogammaglobulinemia:

41
B Cells, T Cells, Brain, Liver, Heart, Small Intestine, Monocytes
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Publications for Transient Hypogammaglobulinemia

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Articles related to Transient Hypogammaglobulinemia:

(show top 50) (show all 100)
# Title Authors PMID Year
1
The Natural History of Untreated Primary Hypogammaglobulinemia in Adults: Implications for the Diagnosis and Treatment of Common Variable Immunodeficiency Disorders (CVID). 38
31379811 2019
2
B lymphocyte subsets and outcomes in patients with an initial diagnosis of transient hypogammaglobulinemia of infancy. 38
30152873 2018
3
Severe Enteropathy and Hypogammaglobulinemia Complicating Refractory Mycobacterium tuberculosis Complex Disseminated Disease in a Child with IL-12Rβ1 Deficiency. 38
28865061 2017
4
[Transient hypogammaglobulinemia of infancy]. 38
28722362 2017
5
Defective pneumococcal antibody response in patients with recurrent respiratory tract infections. 38
29745117 2017
6
Decreased IgM, IgA, and IgG response to pneumococcal vaccine in children with transient hypogammaglobulinemia of infancy. 38
26233927 2016
7
Transient hypogammaglobulinemia and severe atopic dermatitis: Open-label treatment with immunoglobulin in a case series. 38
27470901 2016
8
Fcγ receptor polymorphisms in patients with transient hypogammaglobulinemia of infancy presenting with mild and severe infections. 38
26708396 2015
9
Transient hypogammaglobulinemia of infancy: predictive factors for late recovery. 38
27735798 2015
10
Acquired Immunoglobulin G deficiency in stroke patients and experimental brain ischemia. 38
25959599 2015
11
Severe atopic dermatitis associated with transient hypogammaglobulinemia of infancy. 38
25600656 2015
12
BCGitis in a patient with transient hypogammaglobulinemia of infancy. 38
23253103 2014
13
Quality of life in children with primary antibody deficiency. 38
25005831 2014
14
Primary antibody deficiencies at Queen Rania Children Hospital in Jordan: single center experience. 38
24632588 2014
15
Diagnostic Immunization with Bacteriophage ΦX 174 in Patients with Common Variable Immunodeficiency/Hypogammaglobulinemia. 38
25221555 2014
16
Phenotypic parameters predict time to normalization in infants with hypogammaglobulinemia. 38
24014079 2013
17
Reduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancy. 38
22820757 2013
18
The elevated number of circulating regulatory T cells in patients with transient hypogammaglobulinemia of infancy is not associated with any abnormalities in the genes encoding the TGF-β receptors. 38
23899993 2013
19
Severe parainfluenza pneumonia in a case of transient hypogammalobulinemia of infancy. 38
23814123 2013
20
B-cell subsets in patients with transient hypogammaglobulinemia of infancy, partial IgA deficiency, and selective IgM deficiency. 38
23654075 2013
21
Does intravenous immunoglobulin therapy prolong immunodeficiency in transient hypogammaglobulinemia of infancy? 38
24198926 2013
22
Primary Immunodeficiency May Be Misdiagnosed as Cow's Milk Allergy: Seven Cases Referred to a Tertiary Pediatric Hospital. 38
24198970 2013
23
The efficacy of Pelargonium sidoides in the treatment of upper respiratory tract infections in children with transient hypogammaglobulinemia of infancy. 38
22809962 2012
24
Severe atopic dermatitis and transient hypogammaglobulinemia in children. 38
21854413 2012
25
The number of circulating CD4+ CD25high Foxp3+ T lymphocytes is transiently elevated in the early childhood of transient hypogammaglobulinemia of infancy patients. 38
21531630 2011
26
Study of patients with Hyper-IgM type IV phenotype who recovered spontaneously during late childhood and review of the literature. 38
21274562 2011
27
TNFRSF13B/TACI alterations in Greek patients with antibody deficiencies. 38
21547394 2011
28
Evolution of hypogammaglobulinemia in premature and full-term infants. 38
21978704 2011
29
Outcome of hypogammaglobulinemia in children: immunoglobulin levels as predictors. 38
20851686 2010
30
New laboratory findings in Turkish patients with transient hypogammaglobulinemia of infancy. 38
21131704 2010
31
Infants with low immunoglobulin levels: Isolated low IgA level vs other immunoglobulin abnormalities. 38
20934629 2010
32
Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: 'similarities and differences'. 38
20609138 2010
33
Transient hypogammaglobulinemia of infancy: intravenous immunoglobulin as first line therapy. 38
20378022 2010
34
Clinical features and follow-up of Chinese patients with symptomatic hypogammaglobulinemia in infancy. 38
19781364 2009
35
Atopy in preschool Italian children with recurrent respiratory infections. 38
19839398 2009
36
The B-cell compartment in the peripheral blood of children with different types of primary humoral immunodeficiency. 38
19342988 2009
37
CHARGE (coloboma, heart defect, atresia choanae, retarded growth and development, genital hypoplasia, ear anomalies/deafness) syndrome and chromosome 22q11.2 deletion syndrome: a comparison of immunologic and nonimmunologic phenotypic features. 38
19403480 2009
38
Massive empyema associated with transient hypogammaglobulinemia of infancy and IgA deficiency. 38
19399287 2009
39
Cytogenetic and array CGH characterization of de novo 1p36 duplications and deletion in a patient with congenital cataracts, hearing loss, choanal atresia, and mental retardation. 38
18924166 2008
40
A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: results from the Italian Primary Immunodeficiency Network. 38
18547478 2008
41
Low serum immunoglobulin G2 levels in infancy can be transient. 38
17682036 2007
42
Atopic dermatitis and transient hypogammaglobulinemia of infancy improved simultaneously. 38
17532847 2007
43
Two children with invasive gastrointestinal aspergillosis. 38
17536141 2007
44
Transient hypogammaglobulinemia after antiepileptic drug hypersensitivity. 38
17509469 2007
45
The four most common pediatric immunodeficiencies. 38
17712988 2007
46
Impaired specific antibody response and increased B-cell population in transient hypogammaglobulinemia of infancy. 38
17165264 2006
47
The expression of CD40 on monocytes of children with primary humoral immunodeficiencies. 38
16641210 2006
48
Drug neosensitization during anticonvulsant hypersensitivity syndrome. 38
17039674 2006
49
Infants presenting with recurrent infections and low immunoglobulins: characteristics and analysis of normalization. 38
16418798 2006
50
Different patterns of cytokines, ECP and immunoglobulin profiles at two adverse drug reactions in a patient. 38
16354212 2005
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Variations for Transient Hypogammaglobulinemia

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Expression for Transient Hypogammaglobulinemia

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Search GEO for disease gene expression data for Transient Hypogammaglobulinemia.
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Pathways for Transient Hypogammaglobulinemia

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Pathways related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 64
Show member pathways
 13.55 TNF TGFBR2 TGFBR1 LTA IL10
2
PEDF Induced Signaling 64
Show member pathways
 13.37 TNF TGFBR2 TGFBR1 LTA IL10
3
TGF-Beta Pathway 64
Show member pathways
 13.21 TNF TGFBR2 TGFBR1 LTA IL10
4
PAK Pathway 64
Show member pathways
 12.94 TNF TGFBR2 TGFBR1 LTA IL10
5
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.8 TNF TGFBR2 TGFBR1 IL10
6
NF-kappaB Signaling 4
12.33 TNF IL10 CD19
7
Th17 cell differentiation 37
Show member pathways
 12.21 TNF TGFBR2 TGFBR1 IL10
8
Colorectal Cancer Metastasis 64
11.94 TNF TGFBR2 TGFBR1
9
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.85 TGFBR2 TGFBR1 IL10
10
FoxO signaling pathway 37
Show member pathways
 11.85 TGFBR2 TGFBR1 IL10
11
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.83 TNF TGFBR1 LTA IL10
12
Osteoclast differentiation 37
11.81 TNF TGFBR2 TGFBR1
13
Human T-cell leukemia virus 1 infection 37
11.8 TNF TGFBR2 TGFBR1 LTA
14
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.75 TNF IL10 CD19
15
AGE-RAGE signaling pathway in diabetic complications 37
11.67 TNF TGFBR2 TGFBR1
16
TGF-beta signaling pathway (KEGG) 37
11.61 TNF TGFBR2 TGFBR1
17
Innate Lymphoid Cell Differentiation Pathways 65
11.51 TNF LTA IL10
18
IL4-mediated signaling events 1
11.48 LTA IL10
19
Dendritic Cells Developmental Lineage Pathway 65
11.45 TNF IL10 CD19
20
Transcription_NF-kB signaling pathway 22
11.41 TNF LTA
21
B Cell Development Pathways 65
11.4 IL10 CD19
22
TGF-beta receptor signaling (Pathway Interaction Database) 1
11.38 TGFBR2 TGFBR1
23
Cellular Transformation by HTLV1 64
Show member pathways
 11.36 TNF LTA
24
Malaria 37
11.35 TNF IL10
25
Interleukin-10 signaling 66
11.34 TNF IL10
26
Cell adhesion_Plasmin signaling 22
11.34 TGFBR2 TGFBR1
27
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.3 TNF TGFBR1
28
African trypanosomiasis 37
11.2 TNF IL10
29
TGF-beta Receptor Signaling (WikiPathways) 1
11.2 TNF TGFBR2 TGFBR1
30
IL-10 Pathway 64
11.18 TNF IL10
31
Th1 Differentiation Pathway 65
Show member pathways
 11.14 TNF TGFBR2 TGFBR1 LTA IL10
32
Extracellular vesicle-mediated signaling in recipient cells 1
11.1 TGFBR2 TGFBR1
33
Cytokines and Inflammatory Response 1
11.08 TNF IL10
34
ALK1 signaling events 1
Show member pathways
 11.04 TGFBR2 TGFBR1
35
OX40 Pathway 64
11.02 LTA IL10
36
Glypican 1 network 1
11.01 TGFBR2 TGFBR1
37
Hypothesized Pathways in Pathogenesis of Cardiovascular Disease 1
10.99 TGFBR2 TGFBR1
38
G-protein signaling_RhoB regulation pathway 22
10.96 TNF LTA IL10
39
NTHi-Induced Signaling 64
10.91 TGFBR2 TGFBR1
40
Microglia Activation During Neuroinflammation: Steady-State Microglia 65
10.79 TGFBR2 TGFBR1 IL10
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GO Terms for Transient Hypogammaglobulinemia

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Cellular components related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 TNF TGFBR2 CD19
2 membrane raft GO:0045121 8.8 TNF TGFBR2 TGFBR1

Biological processes related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.81 TNF TGFBR1 LTA
2 response to drug GO:0042493 9.79 TGFBR2 LTA IL10
3 regulation of gene expression GO:0010468 9.72 TGFBR2 TGFBR1 IL10
4 positive regulation of protein kinase B signaling GO:0051897 9.69 TNF TGFBR1 CD19
5 response to glucocorticoid GO:0051384 9.66 TNF IL10
6 pattern specification process GO:0007389 9.65 TGFBR2 TGFBR1
7 peptidyl-threonine phosphorylation GO:0018107 9.65 TGFBR2 TGFBR1
8 humoral immune response GO:0006959 9.65 TNF LTA
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.64 TNF TGFBR2
10 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.64 TNF IL10
11 positive regulation of interferon-gamma production GO:0032729 9.63 TNF LTA
12 positive regulation of epithelial to mesenchymal transition GO:0010718 9.62 TGFBR2 TGFBR1
13 ventricular septum morphogenesis GO:0060412 9.61 TGFBR2 TGFBR1
14 negative regulation of endothelial cell proliferation GO:0001937 9.61 TNF TGFBR1
15 lens development in camera-type eye GO:0002088 9.6 TGFBR2 TGFBR1
16 negative regulation of mitotic cell cycle GO:0045930 9.59 TNF IL10
17 embryonic cranial skeleton morphogenesis GO:0048701 9.58 TGFBR2 TGFBR1
18 negative regulation of interleukin-6 production GO:0032715 9.58 TNF IL10
19 response to organic substance GO:0010033 9.58 TNF TGFBR2 IL10
20 regulation of synapse organization GO:0050807 9.57 TNF IL10
21 positive regulation of cytokine secretion GO:0050715 9.56 TNF IL10
22 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.54 TGFBR2 TGFBR1
23 positive regulation of glial cell proliferation GO:0060252 9.52 TNF LTA
24 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.49 TNF IL10
25 pathway-restricted SMAD protein phosphorylation GO:0060389 9.48 TGFBR2 TGFBR1
26 response to cholesterol GO:0070723 9.46 TGFBR2 TGFBR1
27 endothelial cell apoptotic process GO:0072577 9.43 TNF IL10
28 negative regulation of cytokine secretion involved in immune response GO:0002740 9.37 TNF IL10
29 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.32 TNF LTA
30 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.26 TGFBR2 TGFBR1
31 receptor biosynthetic process GO:0032800 9.16 TNF IL10
32 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 TNF LTA
33 negative regulation of growth of symbiont in host GO:0044130 8.8 TNF LTA IL10

Molecular functions related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD binding GO:0046332 9.4 TGFBR2 TGFBR1
2 growth factor binding GO:0019838 9.37 TGFBR2 TGFBR1
3 cytokine activity GO:0005125 9.33 TNF LTA IL10
4 tumor necrosis factor receptor binding GO:0005164 9.32 TNF LTA
5 transforming growth factor beta binding GO:0050431 9.26 TGFBR2 TGFBR1
6 transforming growth factor beta-activated receptor activity GO:0005024 8.96 TGFBR2 TGFBR1
7 transmembrane receptor protein serine/threonine kinase activity GO:0004675 8.62 TGFBR2 TGFBR1
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Sources for Transient Hypogammaglobulinemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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