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MCID: TRN016
MIFTS: 35

Transient Hypogammaglobulinemia

Categories: Blood diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Transient Hypogammaglobulinemia

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MalaCards integrated aliases for Transient Hypogammaglobulinemia:

Name: Transient Hypogammaglobulinemia 12 15 71

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:625
NCIt 49 C27319
UMLS 71 C0859960
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Summaries for Transient Hypogammaglobulinemia

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MalaCards based summary : Transient Hypogammaglobulinemia is related to transient hypogammaglobulinemia of infancy and agammaglobulinemia. An important gene associated with Transient Hypogammaglobulinemia is CD19 (CD19 Molecule), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include b cells, t cells and brain, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Transient Hypogammaglobulinemia

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Diseases in the Transient Hypogammaglobulinemia family:

Congenital Hypogammaglobulinemia Transient Hypogammaglobulinemia of Infancy

Diseases related to Transient Hypogammaglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 283)
# Related Disease Score Top Affiliating Genes
1 transient hypogammaglobulinemia of infancy 32.4 TGFBR2 TGFBR1 RNU4ATAC CD40LG CD19 BTK
2 agammaglobulinemia 30.4 TNF CD40LG CD19 BTK
3 immunoglobulin alpha deficiency 30.0 CD40LG CD19 BTK
4 food allergy 29.9 TNF IL10 CD19
5 bronchitis 29.9 TNF IL10 CD40LG
6 otitis media 29.8 TNF IL10 CD40LG
7 tetanus 29.7 TNF LTA IL10 CD40LG
8 meningoencephalitis 29.6 TNF IL10 CD40LG
9 rubella 29.6 TNF IL10 CD40LG
10 immunoglobulin a deficiency 1 29.5 LTA CD40LG BTK
11 diarrhea 29.4 TNF IL10 CD40LG
12 dermatitis, atopic 29.4 TNF LTA IL10 CD40LG CD19
13 exanthem 29.3 TNF IL10 CD40LG CD19
14 autoimmune disease 29.3 TNF LTA IL10 CD40LG
15 immune deficiency disease 29.2 TNF IL10 CD40LG BTK
16 poliomyelitis 29.0 TNF IL10 CD40LG BTK
17 bacterial infectious disease 29.0 TNF IL10 CD40LG BTK
18 meningitis 29.0 TNF IL10 CD40LG BTK
19 common variable immunodeficiency 28.9 TNF IL10 CD40LG CD19 BTK
20 microcephaly with chemotactic defect and transient hypogammaglobulinemia 12.5
21 streptococcal toxic-shock syndrome 10.4 TNF LTA
22 punctate inner choroidopathy 10.4 TNF IL10
23 tropical endomyocardial fibrosis 10.4 TNF IL10
24 endomyocardial fibrosis 10.4 TNF IL10
25 null-cell leukemia 10.4 TNF LTA
26 eye lymphoma 10.4 IL10 CD19
27 multifocal choroiditis 10.4 TNF IL10
28 spondylarthropathy 10.4 TNF LTA
29 spotted fever rickettsiosis 10.4 TNF IL10
30 palladium allergic contact dermatitis 10.4 TNF IL10
31 combined thymoma 10.3 TNF IL10
32 orofacial granulomatosis 10.3 TNF IL10
33 transverse myelitis 10.3 TNF IL10
34 eales disease 10.3 TNF IL10
35 chemical colitis 10.3 TNF IL10
36 clonorchiasis 10.3 TNF IL10
37 epstein-barr virus-associated gastric carcinoma 10.3 TNF IL10
38 mucocutaneous leishmaniasis 10.3 TNF IL10
39 macs syndrome 10.3 TNF IL10
40 polyarticular juvenile idiopathic arthritis 10.3 TNF BTK
41 chronic conjunctivitis 10.2 TNF IL10
42 cow milk allergy 10.2 TNF IL10
43 tricuspid valve prolapse 10.2 TGFBR2 TGFBR1
44 eisenmenger syndrome 10.2 TGFBR2 TGFBR1
45 loeys-dietz syndrome 5 10.2 TGFBR2 TGFBR1
46 viral pneumonia 10.2 TNF IL10
47 heritable thoracic aortic disease 10.2 TGFBR2 TGFBR1
48 pulsating exophthalmos 10.2 TGFBR2 TGFBR1
49 multiple self-healing squamous epithelioma 10.2 TGFBR2 TGFBR1
50 monoclonal paraproteinemia 10.2 CD40LG CD19

Graphical network of the top 20 diseases related to Transient Hypogammaglobulinemia:



Diseases related to Transient Hypogammaglobulinemia
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Symptoms & Phenotypes for Transient Hypogammaglobulinemia

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GenomeRNAi Phenotypes related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.28 CD40LG IL10 LTA TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.28 BTK CD40LG IL10 LTA TNF

MGI Mouse Phenotypes related to Transient Hypogammaglobulinemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 CD19 CD40LG IL10 LTA TGFBR1 TGFBR2
2 hematopoietic system MP:0005397 9.86 BTK CD19 CD40LG IL10 LTA TGFBR1
3 digestive/alimentary MP:0005381 9.8 BTK CD19 IL10 TGFBR1 TGFBR2 TNF
4 immune system MP:0005387 9.76 BTK CD19 CD40LG IL10 LTA TGFBR1
5 integument MP:0010771 9.5 BTK CD19 CD40LG IL10 TGFBR1 TGFBR2
6 neoplasm MP:0002006 9.1 BTK CD19 IL10 TGFBR1 TGFBR2 TNF
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Drugs & Therapeutics for Transient Hypogammaglobulinemia

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Search Clinical Trials , NIH Clinical Center for Transient Hypogammaglobulinemia

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Genetic Tests for Transient Hypogammaglobulinemia

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Anatomical Context for Transient Hypogammaglobulinemia

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MalaCards organs/tissues related to Transient Hypogammaglobulinemia:

40
B Cells, T Cells, Brain, Heart, Small Intestine, Liver, Monocytes
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Publications for Transient Hypogammaglobulinemia

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Articles related to Transient Hypogammaglobulinemia:

(show top 50) (show all 101)
# Title Authors PMID Year
1
Acute mastoiditis in a newborn with 11 days of life: Case report. 61
31812003 2019
2
The Natural History of Untreated Primary Hypogammaglobulinemia in Adults: Implications for the Diagnosis and Treatment of Common Variable Immunodeficiency Disorders (CVID). 61
31379811 2019
3
B lymphocyte subsets and outcomes in patients with an initial diagnosis of transient hypogammaglobulinemia of infancy. 61
30152873 2018
4
Severe Enteropathy and Hypogammaglobulinemia Complicating Refractory Mycobacterium tuberculosis Complex Disseminated Disease in a Child with IL-12Rβ1 Deficiency. 61
28865061 2017
5
[Transient hypogammaglobulinemia of infancy]. 61
28722362 2017
6
Defective pneumococcal antibody response in patients with recurrent respiratory tract infections. 61
29745117 2017
7
Decreased IgM, IgA, and IgG response to pneumococcal vaccine in children with transient hypogammaglobulinemia of infancy. 61
26233927 2016
8
Transient hypogammaglobulinemia and severe atopic dermatitis: Open-label treatment with immunoglobulin in a case series. 61
27470901 2016
9
Fcγ receptor polymorphisms in patients with transient hypogammaglobulinemia of infancy presenting with mild and severe infections. 61
26708396 2015
10
Transient hypogammaglobulinemia of infancy: predictive factors for late recovery. 61
27735798 2015
11
Acquired Immunoglobulin G deficiency in stroke patients and experimental brain ischemia. 61
25959599 2015
12
Severe atopic dermatitis associated with transient hypogammaglobulinemia of infancy. 61
25600656 2015
13
BCGitis in a patient with transient hypogammaglobulinemia of infancy. 61
23253103 2014
14
Quality of life in children with primary antibody deficiency. 61
25005831 2014
15
Primary antibody deficiencies at Queen Rania Children Hospital in Jordan: single center experience. 61
24632588 2014
16
Diagnostic Immunization with Bacteriophage ΦX 174 in Patients with Common Variable Immunodeficiency/Hypogammaglobulinemia. 61
25221555 2014
17
Phenotypic parameters predict time to normalization in infants with hypogammaglobulinemia. 61
24014079 2013
18
Reduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancy. 61
22820757 2013
19
The elevated number of circulating regulatory T cells in patients with transient hypogammaglobulinemia of infancy is not associated with any abnormalities in the genes encoding the TGF-β receptors. 61
23899993 2013
20
Severe parainfluenza pneumonia in a case of transient hypogammalobulinemia of infancy. 61
23814123 2013
21
B-cell subsets in patients with transient hypogammaglobulinemia of infancy, partial IgA deficiency, and selective IgM deficiency. 61
23654075 2013
22
Does intravenous immunoglobulin therapy prolong immunodeficiency in transient hypogammaglobulinemia of infancy? 61
24198926 2013
23
Primary Immunodeficiency May Be Misdiagnosed as Cow's Milk Allergy: Seven Cases Referred to a Tertiary Pediatric Hospital. 61
24198970 2013
24
The efficacy of Pelargonium sidoides in the treatment of upper respiratory tract infections in children with transient hypogammaglobulinemia of infancy. 61
22809962 2012
25
Severe atopic dermatitis and transient hypogammaglobulinemia in children. 61
21854413 2012
26
The number of circulating CD4+ CD25high Foxp3+ T lymphocytes is transiently elevated in the early childhood of transient hypogammaglobulinemia of infancy patients. 61
21531630 2011
27
Study of patients with Hyper-IgM type IV phenotype who recovered spontaneously during late childhood and review of the literature. 61
21274562 2011
28
TNFRSF13B/TACI alterations in Greek patients with antibody deficiencies. 61
21547394 2011
29
Evolution of hypogammaglobulinemia in premature and full-term infants. 61
21978704 2011
30
Outcome of hypogammaglobulinemia in children: immunoglobulin levels as predictors. 61
20851686 2010
31
New laboratory findings in Turkish patients with transient hypogammaglobulinemia of infancy. 61
21131704 2010
32
Infants with low immunoglobulin levels: Isolated low IgA level vs other immunoglobulin abnormalities. 61
20934629 2010
33
Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: 'similarities and differences'. 61
20609138 2010
34
Transient hypogammaglobulinemia of infancy: intravenous immunoglobulin as first line therapy. 61
20378022 2010
35
Clinical features and follow-up of Chinese patients with symptomatic hypogammaglobulinemia in infancy. 61
19781364 2009
36
Atopy in preschool Italian children with recurrent respiratory infections. 61
19839398 2009
37
The B-cell compartment in the peripheral blood of children with different types of primary humoral immunodeficiency. 61
19342988 2009
38
CHARGE (coloboma, heart defect, atresia choanae, retarded growth and development, genital hypoplasia, ear anomalies/deafness) syndrome and chromosome 22q11.2 deletion syndrome: a comparison of immunologic and nonimmunologic phenotypic features. 61
19403480 2009
39
Massive empyema associated with transient hypogammaglobulinemia of infancy and IgA deficiency. 61
19399287 2009
40
Cytogenetic and array CGH characterization of de novo 1p36 duplications and deletion in a patient with congenital cataracts, hearing loss, choanal atresia, and mental retardation. 61
18924166 2008
41
A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: results from the Italian Primary Immunodeficiency Network. 61
18547478 2008
42
Low serum immunoglobulin G2 levels in infancy can be transient. 61
17682036 2007
43
Atopic dermatitis and transient hypogammaglobulinemia of infancy improved simultaneously. 61
17532847 2007
44
Two children with invasive gastrointestinal aspergillosis. 61
17536141 2007
45
Transient hypogammaglobulinemia after antiepileptic drug hypersensitivity. 61
17509469 2007
46
The four most common pediatric immunodeficiencies. 61
17712988 2007
47
Impaired specific antibody response and increased B-cell population in transient hypogammaglobulinemia of infancy. 61
17165264 2006
48
The expression of CD40 on monocytes of children with primary humoral immunodeficiencies. 61
16641210 2006
49
Drug neosensitization during anticonvulsant hypersensitivity syndrome. 61
17039674 2006
50
Infants presenting with recurrent infections and low immunoglobulins: characteristics and analysis of normalization. 61
16418798 2006
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Variations for Transient Hypogammaglobulinemia

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Expression for Transient Hypogammaglobulinemia

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Search GEO for disease gene expression data for Transient Hypogammaglobulinemia.
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Pathways for Transient Hypogammaglobulinemia

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Pathways related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.6 TNF TGFBR2 TGFBR1 LTA IL10 CD40LG
2
PEDF Induced Signaling 63
Show member pathways
 13.43 TNF TGFBR2 TGFBR1 LTA IL10 CD40LG
3
TGF-Beta Pathway 63
Show member pathways
 13.35 TNF TGFBR2 TGFBR1 LTA IL10 BTK
4
Akt Signaling 63
Show member pathways
 13.19 TNF TGFBR1 LTA IL10 CD40LG BTK
5
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 12.94 TNF TGFBR2 TGFBR1 IL10 BTK
6
Allograft rejection 36 1
Show member pathways
 12.68 TNF LTA IL10 CD40LG
7
PAK Pathway 63
Show member pathways
 12.57 TNF TGFBR2 TGFBR1 LTA IL10 CD40LG
8
Immune response NFAT in immune response 22
Show member pathways
 12.48 TNF IL10 CD40LG BTK
9
Th17 cell differentiation 36
Show member pathways
 12.44 TNF TGFBR2 TGFBR1 IL10
10
NF-kappaB Signaling 4
12.17 TNF IL10 CD40LG CD19 BTK
11
Toxoplasmosis 36
Show member pathways
 12.12 TNF IL10 CD40LG
12
Human T-cell leukemia virus 1 infection 36
12.12 TNF TGFBR2 TGFBR1 LTA
13
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.1 TNF TGFBR1 LTA IL10
14
C-type lectin receptor signaling pathway 36
Show member pathways
 12.06 TNF IL10 BTK
15
Colorectal Cancer Metastasis 63
12.04 TNF TGFBR2 TGFBR1
16
FoxO signaling pathway 36
Show member pathways
 11.94 TGFBR2 TGFBR1 IL10
17
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.86 TNF IL10 CD19
18
AGE-RAGE signaling pathway in diabetic complications 36
11.78 TNF TGFBR2 TGFBR1
19
TGF-beta signaling pathway (KEGG) 36
11.73 TNF TGFBR2 TGFBR1
20
Osteoclast differentiation 36
11.73 TNF TGFBR2 TGFBR1 BTK
21
Innate Lymphoid Cell Differentiation Pathways 64
11.64 TNF LTA IL10
22
Dendritic Cells Developmental Lineage Pathway 64
11.58 TNF IL10 CD19
23
IL4-mediated signaling events 1
11.5 LTA IL10 CD40LG
24
NF-kappa B signaling pathway 36
11.47 TNF LTA CD40LG BTK
25
TGF-beta Receptor Signaling (WikiPathways) 1
11.45 TNF TGFBR2 TGFBR1
26
B Cell Development Pathways 64
11.36 IL10 CD40LG CD19
27
Malaria 36
11.31 TNF IL10 CD40LG
28
Microglia Activation During Neuroinflammation: Steady-State Microglia 64
11.23 TGFBR2 TGFBR1 IL10
29
Th1 Differentiation Pathway 64
Show member pathways
 11.14 TNF TGFBR2 TGFBR1 LTA IL10
30
Cytokines and Inflammatory Response 1
11.13 TNF IL10
31
Primary immunodeficiency 36
11.12 CD40LG CD19 BTK
32
ALK1 signaling events 1
Show member pathways
 11.1 TGFBR2 TGFBR1
33
OX40 Pathway 63
11.08 LTA IL10
34
Glypican 1 network 1
11.07 TGFBR2 TGFBR1
35
Hypothesized Pathways in Pathogenesis of Cardiovascular Disease 1
11.05 TGFBR2 TGFBR1
36
NTHi-Induced Signaling 63
10.96 TGFBR2 TGFBR1
37
G-protein signaling_Rap2B regulation pathway 22
10.8 TNF LTA IL10 CD40LG BTK
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GO Terms for Transient Hypogammaglobulinemia

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Cellular components related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.26 TNF TGFBR2 CD40LG CD19
2 membrane raft GO:0045121 9.02 TNF TGFBR2 TGFBR1 CD19 BTK

Biological processes related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.88 TNF LTA IL10 CD40LG
2 positive regulation of protein kinase B signaling GO:0051897 9.77 TNF TGFBR1 CD19
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.74 TNF CD40LG BTK
4 tumor necrosis factor-mediated signaling pathway GO:0033209 9.65 TNF LTA CD40LG
5 regulation of synapse organization GO:0050807 9.61 TNF IL10
6 positive regulation of cytokine secretion GO:0050715 9.6 TNF IL10
7 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.58 TGFBR2 TGFBR1
8 positive regulation of glial cell proliferation GO:0060252 9.56 TNF LTA
9 activin receptor signaling pathway GO:0032924 9.55 TGFBR2 TGFBR1
10 negative regulation of B cell proliferation GO:0030889 9.54 IL10 BTK
11 negative regulation of cytokine production GO:0001818 9.52 IL10 BTK
12 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.51 TNF IL10
13 pathway-restricted SMAD protein phosphorylation GO:0060389 9.49 TGFBR2 TGFBR1
14 response to cholesterol GO:0070723 9.46 TGFBR2 TGFBR1
15 endothelial cell apoptotic process GO:0072577 9.43 TNF IL10
16 negative regulation of cytokine secretion involved in immune response GO:0002740 9.4 TNF IL10
17 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.37 TGFBR2 TGFBR1
18 regulation of immunoglobulin secretion GO:0051023 9.32 TNF CD40LG
19 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.26 TNF LTA
20 receptor biosynthetic process GO:0032800 9.16 TNF IL10
21 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 TNF LTA
22 response to organic substance GO:0010033 8.92 TNF TGFBR2 IL10 BTK

Molecular functions related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta binding GO:0050431 9.37 TGFBR2 TGFBR1
2 activin binding GO:0048185 9.32 TGFBR2 TGFBR1
3 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.26 TGFBR2 TGFBR1
4 cytokine activity GO:0005125 9.26 TNF LTA IL10 CD40LG
5 transforming growth factor beta-activated receptor activity GO:0005024 9.16 TGFBR2 TGFBR1
6 tumor necrosis factor receptor binding GO:0005164 8.8 TNF LTA CD40LG
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Sources for Transient Hypogammaglobulinemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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