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MCID: TRN016
MIFTS: 34

Transient Hypogammaglobulinemia

Categories: Blood diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Transient Hypogammaglobulinemia

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MalaCards integrated aliases for Transient Hypogammaglobulinemia:

Name: Transient Hypogammaglobulinemia 12 15 71

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:625
NCIt 49 C27319
UMLS 71 C0859960
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Summaries for Transient Hypogammaglobulinemia

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MalaCards based summary : Transient Hypogammaglobulinemia is related to transient hypogammaglobulinemia of infancy and agammaglobulinemia. An important gene associated with Transient Hypogammaglobulinemia is CD19 (CD19 Molecule), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include b cells, t cells and brain, and related phenotypes are hematopoietic system and immune system

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Related Diseases for Transient Hypogammaglobulinemia

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Diseases in the Transient Hypogammaglobulinemia family:

Congenital Hypogammaglobulinemia Transient Hypogammaglobulinemia of Infancy

Diseases related to Transient Hypogammaglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 309)
# Related Disease Score Top Affiliating Genes
1 transient hypogammaglobulinemia of infancy 32.4 TNFRSF13B TGFBR2 TGFBR1 RNU4ATAC CD40LG CD19
2 agammaglobulinemia 31.1 TNF CD40LG CD19
3 bronchitis 30.1 TNF IL10 CD40LG
4 food allergy 30.0 TNF IL10 CD19
5 otitis media 29.9 TNF IL10 CD40LG
6 tetanus 29.9 TNF LTA IL10 CD40LG
7 bacterial infectious disease 29.8 TNF IL10 CD40LG
8 meningitis 29.8 TNF IL10 CD40LG
9 poliomyelitis 29.8 TNF IL10 CD40LG
10 meningoencephalitis 29.8 TNF IL10 CD40LG
11 exanthem 29.8 TNF IL10 CD40LG
12 immunoglobulin alpha deficiency 29.8 TNFRSF13B CD40LG CD19
13 rubella 29.8 TNF IL10 CD40LG
14 urticaria 29.7 TNF IL10 CD40LG
15 dysgammaglobulinemia 29.1 TNFRSF13B RNU4ATAC CD40LG
16 common variable immunodeficiency 28.8 TNFRSF13B TNF IL10 CD40LG CD19
17 immunoglobulin a deficiency 1 28.8 TNFRSF13B RNU4ATAC LTA CD40LG
18 autoimmune disease 28.5 TNFRSF13B TNF LTA IL10 CD40LG
19 immune deficiency disease 28.5 TNFRSF13B TNF LTA IL10 CD40LG
20 microcephaly with chemotactic defect and transient hypogammaglobulinemia 12.5
21 streptococcal toxic-shock syndrome 10.4 TNF LTA
22 punctate inner choroidopathy 10.4 TNF IL10
23 tropical endomyocardial fibrosis 10.4 TNF IL10
24 endomyocardial fibrosis 10.4 TNF IL10
25 null-cell leukemia 10.4 TNF LTA
26 eye lymphoma 10.4 IL10 CD19
27 multifocal choroiditis 10.4 TNF IL10
28 spotted fever rickettsiosis 10.4 TNF IL10
29 palladium allergic contact dermatitis 10.4 TNF IL10
30 spondylarthropathy 10.4 TNF LTA
31 metal allergy 10.4 TNF IL10
32 orofacial granulomatosis 10.4 TNF IL10
33 transverse myelitis 10.4 TNF IL10
34 eales disease 10.4 TNF IL10
35 chemical colitis 10.3 TNF IL10
36 hypopyon 10.3 TNF IL10
37 pneumonic plague 10.3 TNF IL10
38 progressive myoclonus epilepsy 8 10.3 TNF IL10
39 epstein-barr virus-associated gastric carcinoma 10.3 TNF IL10
40 congenital hypogammaglobulinemia 10.3 CD40LG CD19
41 mucocutaneous leishmaniasis 10.3 TNF IL10
42 coccidioidomycosis 10.3 TNF CD40LG
43 tricuspid valve prolapse 10.3 TGFBR2 TGFBR1
44 clonorchiasis 10.3 TNF IL10
45 eisenmenger syndrome 10.3 TGFBR2 TGFBR1
46 macs syndrome 10.3 TNF IL10
47 loeys-dietz syndrome 5 10.3 TGFBR2 TGFBR1
48 cerebral lymphoma 10.3 CD40LG CD19
49 multiple self-healing squamous epithelioma 10.3 TGFBR2 TGFBR1
50 alpha chain disease 10.3 CD40LG CD19

Graphical network of the top 20 diseases related to Transient Hypogammaglobulinemia:



Diseases related to Transient Hypogammaglobulinemia
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Symptoms & Phenotypes for Transient Hypogammaglobulinemia

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MGI Mouse Phenotypes related to Transient Hypogammaglobulinemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.86 CD19 CD40LG IL10 LTA TGFBR1 TGFBR2
2 immune system MP:0005387 9.76 CD19 CD40LG IL10 LTA TGFBR1 TGFBR2
3 liver/biliary system MP:0005370 9.43 CD19 IL10 LTA TGFBR2 TNF TNFRSF13B
4 neoplasm MP:0002006 9.1 CD19 IL10 TGFBR1 TGFBR2 TNF TNFRSF13B
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Drugs & Therapeutics for Transient Hypogammaglobulinemia

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Search Clinical Trials , NIH Clinical Center for Transient Hypogammaglobulinemia

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Genetic Tests for Transient Hypogammaglobulinemia

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Anatomical Context for Transient Hypogammaglobulinemia

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MalaCards organs/tissues related to Transient Hypogammaglobulinemia:

40
B Cells, T Cells, Brain, Heart, Small Intestine, Liver, Monocytes
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Publications for Transient Hypogammaglobulinemia

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Articles related to Transient Hypogammaglobulinemia:

(show top 50) (show all 102)
# Title Authors PMID Year
1
Acute mastoiditis in a newborn with 11 days of life: Case report. 61
31812003 2020
2
Diagnostic approach of hypogammaglobulinemia in infancy. 61
32017208 2020
3
The Natural History of Untreated Primary Hypogammaglobulinemia in Adults: Implications for the Diagnosis and Treatment of Common Variable Immunodeficiency Disorders (CVID). 61
31379811 2019
4
B lymphocyte subsets and outcomes in patients with an initial diagnosis of transient hypogammaglobulinemia of infancy. 61
30152873 2018
5
Severe Enteropathy and Hypogammaglobulinemia Complicating Refractory Mycobacterium tuberculosis Complex Disseminated Disease in a Child with IL-12Rβ1 Deficiency. 61
28865061 2017
6
[Transient hypogammaglobulinemia of infancy]. 61
28722362 2017
7
Defective pneumococcal antibody response in patients with recurrent respiratory tract infections. 61
29745117 2017
8
Decreased IgM, IgA, and IgG response to pneumococcal vaccine in children with transient hypogammaglobulinemia of infancy. 61
26233927 2016
9
Transient hypogammaglobulinemia and severe atopic dermatitis: Open-label treatment with immunoglobulin in a case series. 61
27470901 2016
10
Fcγ receptor polymorphisms in patients with transient hypogammaglobulinemia of infancy presenting with mild and severe infections. 61
26708396 2015
11
Transient hypogammaglobulinemia of infancy: predictive factors for late recovery. 61
27735798 2015
12
Acquired Immunoglobulin G deficiency in stroke patients and experimental brain ischemia. 61
25959599 2015
13
Severe atopic dermatitis associated with transient hypogammaglobulinemia of infancy. 61
25600656 2015
14
BCGitis in a patient with transient hypogammaglobulinemia of infancy. 61
23253103 2014
15
Quality of life in children with primary antibody deficiency. 61
25005831 2014
16
Primary antibody deficiencies at Queen Rania Children Hospital in Jordan: single center experience. 61
24632588 2014
17
Diagnostic Immunization with Bacteriophage ΦX 174 in Patients with Common Variable Immunodeficiency/Hypogammaglobulinemia. 61
25221555 2014
18
Phenotypic parameters predict time to normalization in infants with hypogammaglobulinemia. 61
24014079 2013
19
Reduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancy. 61
22820757 2013
20
The elevated number of circulating regulatory T cells in patients with transient hypogammaglobulinemia of infancy is not associated with any abnormalities in the genes encoding the TGF-β receptors. 61
23899993 2013
21
Severe parainfluenza pneumonia in a case of transient hypogammalobulinemia of infancy. 61
23814123 2013
22
B-cell subsets in patients with transient hypogammaglobulinemia of infancy, partial IgA deficiency, and selective IgM deficiency. 61
23654075 2013
23
Does intravenous immunoglobulin therapy prolong immunodeficiency in transient hypogammaglobulinemia of infancy? 61
24198926 2013
24
Primary Immunodeficiency May Be Misdiagnosed as Cow's Milk Allergy: Seven Cases Referred to a Tertiary Pediatric Hospital. 61
24198970 2013
25
The efficacy of Pelargonium sidoides in the treatment of upper respiratory tract infections in children with transient hypogammaglobulinemia of infancy. 61
22809962 2012
26
Severe atopic dermatitis and transient hypogammaglobulinemia in children. 61
21854413 2012
27
The number of circulating CD4+ CD25high Foxp3+ T lymphocytes is transiently elevated in the early childhood of transient hypogammaglobulinemia of infancy patients. 61
21531630 2011
28
Study of patients with Hyper-IgM type IV phenotype who recovered spontaneously during late childhood and review of the literature. 61
21274562 2011
29
TNFRSF13B/TACI alterations in Greek patients with antibody deficiencies. 61
21547394 2011
30
Evolution of hypogammaglobulinemia in premature and full-term infants. 61
21978704 2011
31
Outcome of hypogammaglobulinemia in children: immunoglobulin levels as predictors. 61
20851686 2010
32
New laboratory findings in Turkish patients with transient hypogammaglobulinemia of infancy. 61
21131704 2010
33
Infants with low immunoglobulin levels: Isolated low IgA level vs other immunoglobulin abnormalities. 61
20934629 2010
34
Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: 'similarities and differences'. 61
20609138 2010
35
Transient hypogammaglobulinemia of infancy: intravenous immunoglobulin as first line therapy. 61
20378022 2010
36
Clinical features and follow-up of Chinese patients with symptomatic hypogammaglobulinemia in infancy. 61
19781364 2009
37
Atopy in preschool Italian children with recurrent respiratory infections. 61
19839398 2009
38
The B-cell compartment in the peripheral blood of children with different types of primary humoral immunodeficiency. 61
19342988 2009
39
CHARGE (coloboma, heart defect, atresia choanae, retarded growth and development, genital hypoplasia, ear anomalies/deafness) syndrome and chromosome 22q11.2 deletion syndrome: a comparison of immunologic and nonimmunologic phenotypic features. 61
19403480 2009
40
Massive empyema associated with transient hypogammaglobulinemia of infancy and IgA deficiency. 61
19399287 2009
41
Cytogenetic and array CGH characterization of de novo 1p36 duplications and deletion in a patient with congenital cataracts, hearing loss, choanal atresia, and mental retardation. 61
18924166 2008
42
A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: results from the Italian Primary Immunodeficiency Network. 61
18547478 2008
43
Low serum immunoglobulin G2 levels in infancy can be transient. 61
17682036 2007
44
Atopic dermatitis and transient hypogammaglobulinemia of infancy improved simultaneously. 61
17532847 2007
45
Two children with invasive gastrointestinal aspergillosis. 61
17536141 2007
46
Transient hypogammaglobulinemia after antiepileptic drug hypersensitivity. 61
17509469 2007
47
The four most common pediatric immunodeficiencies. 61
17712988 2007
48
Impaired specific antibody response and increased B-cell population in transient hypogammaglobulinemia of infancy. 61
17165264 2006
49
The expression of CD40 on monocytes of children with primary humoral immunodeficiencies. 61
16641210 2006
50
Drug neosensitization during anticonvulsant hypersensitivity syndrome. 61
17039674 2006
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Variations for Transient Hypogammaglobulinemia

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Expression for Transient Hypogammaglobulinemia

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Search GEO for disease gene expression data for Transient Hypogammaglobulinemia.
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Pathways for Transient Hypogammaglobulinemia

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Pathways related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.62 TNFRSF13B TNF TGFBR2 TGFBR1 LTA IL10
2
PEDF Induced Signaling 63
Show member pathways
 13.4 TNFRSF13B TNF TGFBR2 TGFBR1 LTA IL10
3
Akt Signaling 63
Show member pathways
 13.18 TNFRSF13B TNF TGFBR1 LTA IL10 CD40LG
4
PAK Pathway 63
Show member pathways
 12.57 TNFRSF13B TNF TGFBR2 TGFBR1 LTA IL10
5
Allograft rejection 1 36
Show member pathways
 12.46 TNFRSF13B TNF LTA IL10 CD40LG
6
Th17 cell differentiation 36
Show member pathways
 12.42 TNF TGFBR2 TGFBR1 IL10
7
TRAF Pathway 63
Show member pathways
 12.38 TNFRSF13B TNF LTA CD40LG
8
NF-kappaB Signaling 4
12.34 TNF IL10 CD40LG CD19
9
Toxoplasmosis 36
Show member pathways
 12.11 TNF IL10 CD40LG
10
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.08 TNF TGFBR1 LTA IL10
11
Colorectal Cancer Metastasis 63
12.03 TNF TGFBR2 TGFBR1
12
Human T-cell leukemia virus 1 infection 36
12.01 TNF TGFBR2 TGFBR1 LTA
13
FoxO signaling pathway 36
Show member pathways
 11.94 TGFBR2 TGFBR1 IL10
14
Osteoclast differentiation 36
11.9 TNF TGFBR2 TGFBR1
15
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.85 TNF IL10 CD19
16
IL27-mediated signaling events 1
Show member pathways
 11.8 TNF LTA IL10
17
NF-kappa B signaling pathway 36
11.78 TNF LTA CD40LG
18
AGE-RAGE signaling pathway in diabetic complications 36
11.75 TNF TGFBR2 TGFBR1
19
TGF-beta signaling pathway (KEGG) 36
11.69 TNF TGFBR2 TGFBR1
20
Innate Lymphoid Cells Differentiation 64
11.57 TNF LTA IL10
21
Dendritic Cells Developmental Lineage Pathway 64
11.52 TNF IL10 CD19
22
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 22
Show member pathways
 11.5 TNFRSF13B TNF CD40LG
23
IL4-mediated signaling events 1
11.41 LTA IL10 CD40LG
24
TGF-beta Receptor Signaling (WikiPathways) 1
11.34 TNF TGFBR2 TGFBR1
25
Malaria 36
11.13 TNF IL10 CD40LG
26
ALK1 signaling events 1
Show member pathways
 11.09 TGFBR2 TGFBR1
27
OX40 Pathway 63
11.07 LTA IL10
28
Glypican 1 network 1
11.06 TGFBR2 TGFBR1
29
Hypothesized Pathways in Pathogenesis of Cardiovascular Disease 1
11.04 TGFBR2 TGFBR1
30
NTHi-Induced Signaling 63
10.96 TGFBR2 TGFBR1
31
Primary immunodeficiency 36
10.91 TNFRSF13B CD40LG CD19
32
G-protein signaling_Rap2B regulation pathway 22
10.87 TNF LTA IL10 CD40LG
33
IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
10.86 TGFBR2 TGFBR1
34
TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions 64
Show member pathways
 10.84 TNFRSF13B TNF LTA CD40LG
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GO Terms for Transient Hypogammaglobulinemia

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Cellular components related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.26 TNF TGFBR2 CD40LG CD19
2 membrane raft GO:0045121 8.92 TNF TGFBR2 TGFBR1 CD19

Biological processes related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.88 TNF LTA IL10 CD40LG
2 positive regulation of protein kinase B signaling GO:0051897 9.76 TNF TGFBR1 CD19
3 response to organic substance GO:0010033 9.65 TNF TGFBR2 IL10
4 positive regulation of glial cell proliferation GO:0060252 9.57 TNF LTA
5 activin receptor signaling pathway GO:0032924 9.56 TGFBR2 TGFBR1
6 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.55 TGFBR2 TGFBR1
7 negative regulation of B cell proliferation GO:0030889 9.54 TNFRSF13B IL10
8 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.52 TNF IL10
9 pathway-restricted SMAD protein phosphorylation GO:0060389 9.51 TGFBR2 TGFBR1
10 response to cholesterol GO:0070723 9.49 TGFBR2 TGFBR1
11 endothelial cell apoptotic process GO:0072577 9.46 TNF IL10
12 negative regulation of cytokine production involved in immune response GO:0002719 9.43 TNF IL10
13 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.4 TGFBR2 TGFBR1
14 regulation of immunoglobulin secretion GO:0051023 9.37 TNF CD40LG
15 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.32 TNF LTA
16 negative regulation of cytokine secretion involved in immune response GO:0002740 9.26 TNF IL10
17 receptor biosynthetic process GO:0032800 9.16 TNF IL10
18 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 TNF LTA
19 tumor necrosis factor-mediated signaling pathway GO:0033209 8.92 TNFRSF13B TNF LTA CD40LG

Molecular functions related to Transient Hypogammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta binding GO:0050431 9.37 TGFBR2 TGFBR1
2 activin binding GO:0048185 9.32 TGFBR2 TGFBR1
3 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.26 TGFBR2 TGFBR1
4 cytokine activity GO:0005125 9.26 TNF LTA IL10 CD40LG
5 transforming growth factor beta-activated receptor activity GO:0005024 9.16 TGFBR2 TGFBR1
6 tumor necrosis factor receptor binding GO:0005164 8.8 TNF LTA CD40LG
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Sources for Transient Hypogammaglobulinemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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