MCID: TRN009
MIFTS: 40

Transient Hypogammaglobulinemia of Infancy

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Transient Hypogammaglobulinemia of Infancy

MalaCards integrated aliases for Transient Hypogammaglobulinemia of Infancy:

Name: Transient Hypogammaglobulinemia of Infancy 12 59 15

Classifications:

Orphanet: 59  
Rare immunological diseases


External Ids:

Disease Ontology 12 DOID:624
ICD10 33 D80.7
NCIt 50 C27071
SNOMED-CT 68 88714009
Orphanet 59 ORPHA169139
UMLS via Orphanet 74 C0272238
ICD10 via Orphanet 34 D80.7
UMLS 73 C0272238

Summaries for Transient Hypogammaglobulinemia of Infancy

MalaCards based summary : Transient Hypogammaglobulinemia of Infancy is related to transient hypogammaglobulinemia and agammaglobulinemia. An important gene associated with Transient Hypogammaglobulinemia of Infancy is CD19 (CD19 Molecule), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include b cells, t cells and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Transient hypogammaglobulinemia of infancy is a form of hypogammaglobulinemia appearing after birth,... more...

Related Diseases for Transient Hypogammaglobulinemia of Infancy

Diseases in the Transient Hypogammaglobulinemia family:

Congenital Hypogammaglobulinemia Transient Hypogammaglobulinemia of Infancy

Diseases related to Transient Hypogammaglobulinemia of Infancy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 transient hypogammaglobulinemia 31.1 CD19 IL10 LTA TGFBR1 TGFBR2
2 agammaglobulinemia 30.5 BTK CD19 CR2
3 agammaglobulinemia, x-linked 29.8 BTK CD40 CD40LG IL4
4 familial thoracic aortic aneurysm and dissection 10.2 TGFBR1 TGFBR2
5 congenital rubella 10.2 CD40LG UNG
6 immunodeficiency, common variable, 2 10.2 CD19 CR2 TNFRSF13B
7 immunoglobulin alpha deficiency 10.2
8 cephalosporin allergy 10.2 IL10 TGFBR1
9 lobomycosis 10.2 CD19 CR2
10 light fixation seizure syndrome 10.1 CD40 CD40LG
11 tropical endomyocardial fibrosis 10.1 IL10 IL4
12 endomyocardial fibrosis 10.1 IL10 IL4
13 congenital hypogammaglobulinemia 10.1 BTK CD19 IL4
14 leukocyte disease 10.1 CD19 CR2 IL4
15 dermatitis, atopic 10.1
16 dermatitis 10.1
17 immunodeficiency with hyper-igm, type 4 10.1 CD40 CD40LG UNG
18 cryoglobulinemia 10.1 CD27 CD40LG CD81 CR2
19 cd40 ligand deficiency 10.1 CD40 CD40LG UNG
20 hyperimmunoglobulin syndrome 10.1 CD40 CD40LG UNG
21 lung lymphoma 10.1 ALK CD19 CR2
22 immunodeficiency with hyper-igm, type 2 10.1 CD40 CD40LG UNG
23 immunoglobulin a deficiency 1 10.0 BTK CD40LG LTA TNFRSF13B
24 macroglobulinemia 10.0 BTK CD27 CD40LG TNFRSF13B
25 tungiasis 10.0 IL10 IL4
26 sporotrichosis 10.0 CD40LG IL10
27 cutis laxa, autosomal recessive, type ic 10.0 TGFBR1 TGFBR2
28 sulfamethoxazole allergy 10.0 CD40 CD40LG IL4
29 brucellosis 10.0 CD40LG IL10 IL4
30 poliomyelitis 10.0 BTK IL10 IL4
31 ascaridiasis 10.0 IL10 NELFCD
32 toxic shock syndrome 10.0 IL10 IL4 LTA
33 rubella 10.0 CD40LG IL10 IL4
34 autoimmune disease of musculoskeletal system 10.0 CD19 CD40LG IL10 IL4
35 schistosomiasis 10.0 CD40LG IL10 IL4
36 nickel allergic contact dermatitis 10.0 IL10 IL4
37 waldenstrom macroglobulinemia 10.0 BTK CD27 CD40 CD40LG
38 hyperlucent lung 10.0 IL10 IL4 NELFCD
39 viral infectious disease 9.9 CD40LG CD81 IL10 IL4
40 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.9 BTK CD40LG IL10 IL4
41 burkitt lymphoma 9.9 CD40 CD40LG CR2 IL4
42 tetanus 9.9 CD27 CD40LG IL10 IL4 LTA
43 toxoplasmosis 9.9 CD40 CD40LG IL10 IL4
44 buruli ulcer 9.9 CD40LG IL10 IL4 NELFCD
45 respiratory system disease 9.9 ALK IL10 IL4
46 immunodeficiency with hyper-igm, type 1 9.8 BTK CD40 CD40LG IL4 UNG
47 human immunodeficiency virus type 1 9.8 CCR1 CD40 CR2 IL10 LTA
48 multiple sclerosis 9.8 CCR1 CD40 IL10 IL4 LTA
49 lymphoma, non-hodgkin, familial 9.8 ALK CD19 CD27 CD40 CR2 TNFRSF13B
50 b cell deficiency 9.7 BTK CD19 CD27 CD40 CD40LG CR2

Graphical network of the top 20 diseases related to Transient Hypogammaglobulinemia of Infancy:



Diseases related to Transient Hypogammaglobulinemia of Infancy

Symptoms & Phenotypes for Transient Hypogammaglobulinemia of Infancy

MGI Mouse Phenotypes related to Transient Hypogammaglobulinemia of Infancy:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.4 BTK CCR1 CD19 CD27 CD40 CD40LG
2 homeostasis/metabolism MP:0005376 10.38 ALK BTK CCR1 CD19 CD40 CD40LG
3 immune system MP:0005387 10.36 BTK CCR1 CD19 CD27 CD40 CD40LG
4 mortality/aging MP:0010768 10.22 ALK BTK CCR1 CD19 CD40LG CR2
5 endocrine/exocrine gland MP:0005379 10.16 ALK CD40 CD40LG IL10 IL4 LTA
6 digestive/alimentary MP:0005381 10.07 BTK CCR1 CD19 IL10 IL4 TGFBR1
7 nervous system MP:0003631 10.06 ALK CD19 CD40 CD40LG CD81 IL10
8 liver/biliary system MP:0005370 9.98 CCR1 CD19 IL10 IL4 LTA TGFBR2
9 neoplasm MP:0002006 9.97 ALK BTK CD19 IL10 TGFBR1 TGFBR2
10 normal MP:0002873 9.86 CD19 CD40 CD84 IL10 IL4 TGFBR1
11 renal/urinary system MP:0005367 9.7 CCR1 CD19 CD40 CD40LG CR2 IL4
12 respiratory system MP:0005388 9.56 ALK CCR1 CD81 IL10 IL4 LTA
13 skeleton MP:0005390 9.28 ALK CD40 CD40LG CD81 IL10 IL4

Drugs & Therapeutics for Transient Hypogammaglobulinemia of Infancy

Search Clinical Trials , NIH Clinical Center for Transient Hypogammaglobulinemia of Infancy

Genetic Tests for Transient Hypogammaglobulinemia of Infancy

Anatomical Context for Transient Hypogammaglobulinemia of Infancy

MalaCards organs/tissues related to Transient Hypogammaglobulinemia of Infancy:

41
B Cells, T Cells, Lung, Colon, Small Intestine

Publications for Transient Hypogammaglobulinemia of Infancy

Articles related to Transient Hypogammaglobulinemia of Infancy:

(show all 34)
# Title Authors Year
1
B lymphocyte subsets and outcomes in patients with an initial diagnosis of transient hypogammaglobulinemia of infancy. ( 30152873 )
2018
2
Transient hypogammaglobulinemia of infancy: predictive factors for late recovery. ( 27735798 )
2015
3
FcI^ receptor polymorphisms in patients with transient hypogammaglobulinemia of infancy presenting with mild and severe infections. ( 26708396 )
2015
4
Severe atopic dermatitis associated with transient hypogammaglobulinemia of infancy. ( 25600656 )
2015
5
Decreased IgM, IgA, and IgG response to pneumococcal vaccine in children with transient hypogammaglobulinemia of infancy. ( 26233927 )
2015
6
Does intravenous immunoglobulin therapy prolong immunodeficiency in transient hypogammaglobulinemia of infancy? ( 24198926 )
2013
7
The elevated number of circulating regulatory T cells in patients with transient hypogammaglobulinemia of infancy is not associated with any abnormalities in the genes encoding the TGF-I^ receptors. ( 23899993 )
2013
8
B-cell subsets in patients with transient hypogammaglobulinemia of infancy, partial IgA deficiency, and selective IgM deficiency. ( 23654075 )
2013
9
Reduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancy. ( 22820757 )
2013
10
The efficacy of Pelargonium sidoides in the treatment of upper respiratory tract infections in children with transient hypogammaglobulinemia of infancy. ( 22809962 )
2012
11
BCGitis in a Patient with Transient Hypogammaglobulinemia of Infancy. ( 23253103 )
2012
12
The number of circulating CD4+ CD25high Foxp3+ T lymphocytes is transiently elevated in the early childhood of transient hypogammaglobulinemia of infancy patients. ( 21531630 )
2011
13
New laboratory findings in Turkish patients with transient hypogammaglobulinemia of infancy. ( 21131704 )
2010
14
Transient hypogammaglobulinemia of infancy: intravenous immunoglobulin as first line therapy. ( 20378022 )
2010
15
Massive empyema associated with transient hypogammaglobulinemia of infancy and IgA deficiency. ( 19399287 )
2009
16
A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: results from the Italian Primary Immunodeficiency Network. ( 18547478 )
2008
17
Atopic dermatitis and transient hypogammaglobulinemia of infancy improved simultaneously. ( 17532847 )
2007
18
Impaired specific antibody response and increased B-cell population in transient hypogammaglobulinemia of infancy. ( 17165264 )
2006
19
Transient hypogammaglobulinemia of infancy presenting as Staphylococcus aureus sepsis with deep neck infection. ( 15843860 )
2005
20
Transient hypogammaglobulinemia of infancy and early childhood: outcome of 30 cases. ( 15214739 )
2004
21
Transient hypogammaglobulinemia of infancy: clinical and immunologic features of 40 new cases. ( 11192522 )
2000
22
X-linked agammaglobulinemia presenting as transient hypogammaglobulinemia of infancy. ( 7722175 )
1995
23
Absent specific viral antibodies in patients with transient hypogammaglobulinemia of infancy. ( 2303650 )
1990
24
Transient hypogammaglobulinemia of infancy. ( 2264470 )
1990
25
Transient hypogammaglobulinemia of infancy: Five new cases, review of the literature and redefinition. ( 2596283 )
1989
26
Transient hypogammaglobulinemia of infancy: need to reconsider name and definition. ( 3794886 )
1987
27
Streptococcal sepsis presenting as acute abdomen in a child with transient hypogammaglobulinemia of infancy. ( 3540263 )
1986
28
Transient hypogammaglobulinemia of infancy with severe bacterial infections and persistent IgA deficiency. ( 2427477 )
1986
29
Is transient hypogammaglobulinemia of infancy a manifestation of zinc deficiency? ( 6233190 )
1984
30
Transient hypogammaglobulinemia of infancy. ( 6977720 )
1982
31
Deficiency of T helper cells in transient hypogammaglobulinemia of infancy. ( 6270560 )
1981
32
Transient hypogammaglobulinemia of infancy: review of the literature, clinical and immunologic features of 11 new cases, and long-term follow-up. ( 632973 )
1978
33
Transient hypogammaglobulinemia of infancy. ( 75969 )
1978
34
Transient hypogammaglobulinemia of infancy. ( 908979 )
1977

Variations for Transient Hypogammaglobulinemia of Infancy

Expression for Transient Hypogammaglobulinemia of Infancy

Search GEO for disease gene expression data for Transient Hypogammaglobulinemia of Infancy.

Pathways for Transient Hypogammaglobulinemia of Infancy

Pathways related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 BTK CCR1 CD19 CD27 CD40 CD40LG
2
Show member pathways
13.68 ALK BTK CCR1 CD27 CD40 CD40LG
3
Show member pathways
13.44 ALK BTK CCR1 CD27 CD40 CD40LG
4
Show member pathways
13.28 CCR1 CD27 CD40 CD40LG IL10 IL4
5
Show member pathways
13.14 ALK BTK CCR1 CD27 CD40 CD40LG
6
Show member pathways
12.96 BTK CCR1 CD27 CD40 CD40LG IL10
7
Show member pathways
12.88 BTK CD27 CD40 CD40LG LTA TNFRSF13B
8
Show member pathways
12.83 CD40 CD40LG IL10 IL4 LTA TNFRSF13B
9
Show member pathways
12.65 CD27 CD40 CD40LG CR2 LTA
10
Show member pathways
12.59 BTK CD40 CD40LG IL10 IL4
11
Show member pathways
12.53 BTK CD19 CD81 CR2 IL4
12 12.51 BTK CD19 CD40LG IL10 IL4
13
Show member pathways
12.49 BTK CD27 CD40 CD40LG LTA TNFRSF13B
14 12.38 CD40 LTA TGFBR1 TGFBR2
15
Show member pathways
12.34 BTK CD19 CD81 CR2
16 12.26 BTK CD19 CD40 CR2
17
Show member pathways
12.21 CD40 CD40LG IL10 IL4
18
Show member pathways
12.03 BTK IL10 IL4 TGFBR1 TGFBR2
19 12.02 CD19 CD40 CD40LG CD81
20
Show member pathways
12 IL10 LTA TGFBR1 TGFBR2
21 11.91 CCR1 CD19 IL10 IL4
22 11.84 CD19 CR2 IL4
23 11.77 BTK CD40 CD40LG LTA
24 11.75 IL10 IL4 LTA
25
Show member pathways
11.7 CD40 CD40LG TNFRSF13B
26 11.69 CD40 IL10 IL4
27 11.58 CD27 CD40 CD40LG
28 11.5 CD40LG IL10 IL4 LTA
29 11.49 CCR1 IL10 IL4
30 11.45 IL10 TGFBR1 TGFBR2
31 11.36 CD40 CD40LG CD81 IL10
32 11.25 CD40 CD40LG IL4
33 11.19 CD40 CD40LG IL4
34 11.18 CD27 LTA TNFRSF13B
35 11.1 IL10 IL4 LTA
36 11.09 BTK CD40LG IL10 IL4 LTA
37 11 BTK CD19 CD40 CD40LG TNFRSF13B UNG
38 10.96 ALK BTK CD40LG IL10 IL4 LTA
39 10.95 CD19 CD27 CD40 CD40LG CD84 CR2

GO Terms for Transient Hypogammaglobulinemia of Infancy

Cellular components related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 9.62 ALK CR2 TGFBR1 TGFBR2
2 external side of plasma membrane GO:0009897 9.43 CCR1 CD19 CD27 CD40 CD40LG TGFBR2
3 integral component of plasma membrane GO:0005887 9.36 ALK CCR1 CD19 CD27 CD40 CD40LG
4 transforming growth factor beta receptor complex GO:0070022 9.26 TGFBR1 TGFBR2
5 membrane GO:0016020 10.24 ALK BTK CCR1 CD19 CD27 CD40
6 plasma membrane GO:0005886 10 ALK BTK CCR1 CD19 CD27 CD40

Biological processes related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.95 CCR1 CD40LG CR2 IL10 IL4 LTA
2 cell surface receptor signaling pathway GO:0007166 9.85 CCR1 CD19 CD27 CD81 TNFRSF13B
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 ALK BTK CD40 CD40LG
4 response to organic substance GO:0010033 9.78 BTK IL10 TGFBR2
5 regulation of immune response GO:0050776 9.77 CD19 CD40 CD40LG CD81 IL4
6 negative regulation of apoptotic process GO:0043066 9.7 ALK CD27 CD40LG IL10 IL4 TGFBR1
7 positive regulation of B cell proliferation GO:0030890 9.67 CD40 CD81 IL4
8 B cell differentiation GO:0030183 9.62 CD40LG CR2 IL10 IL4
9 negative regulation of growth of symbiont in host GO:0044130 9.61 IL10 LTA
10 B cell activation GO:0042113 9.61 BTK CD40 IL4
11 pathway-restricted SMAD protein phosphorylation GO:0060389 9.6 TGFBR1 TGFBR2
12 positive regulation of B cell differentiation GO:0045579 9.59 BTK CD27
13 positive regulation of isotype switching to IgG isotypes GO:0048304 9.58 CD40 IL4
14 response to cholesterol GO:0070723 9.58 TGFBR1 TGFBR2
15 positive regulation of MHC class II biosynthetic process GO:0045348 9.57 IL10 IL4
16 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.56 TGFBR1 TGFBR2
17 regulation of immunoglobulin secretion GO:0051023 9.55 CD40 CD40LG
18 regulation of isotype switching GO:0045191 9.52 IL10 IL4
19 type 2 immune response GO:0042092 9.51 IL10 IL4
20 negative regulation of B cell proliferation GO:0030889 9.43 BTK IL10 TNFRSF13B
21 negative regulation of interleukin-18 production GO:0032701 9.4 CD84 IL10
22 B cell proliferation GO:0042100 9.26 CD40 CD40LG CR2 IL10
23 tumor necrosis factor-mediated signaling pathway GO:0033209 9.02 CD27 CD40 CD40LG LTA TNFRSF13B
24 immune system process GO:0002376 10.02 BTK CD40 CD84 CR2 TNFRSF13B

Molecular functions related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.6 ACOT8 ALK BTK CCR1 CD19 CD27
2 transforming growth factor beta-activated receptor activity GO:0005024 9.26 TGFBR1 TGFBR2
3 cytokine activity GO:0005125 9.26 CD40LG IL10 IL4 LTA
4 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.16 TGFBR1 TGFBR2

Sources for Transient Hypogammaglobulinemia of Infancy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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