MCID: TRN009
MIFTS: 36

Transient Hypogammaglobulinemia of Infancy

Categories: Immune diseases, Blood diseases, Rare diseases

Aliases & Classifications for Transient Hypogammaglobulinemia of Infancy

MalaCards integrated aliases for Transient Hypogammaglobulinemia of Infancy:

Name: Transient Hypogammaglobulinemia of Infancy 12 59 15

Classifications:

Orphanet: 59  
Rare immunological diseases


External Ids:

Disease Ontology 12 DOID:624
ICD10 33 D80.7
NCIt 50 C27071
SNOMED-CT 68 88714009
Orphanet 59 ORPHA169139
UMLS via Orphanet 74 C0272238
ICD10 via Orphanet 34 D80.7
UMLS 73 C0272238

Summaries for Transient Hypogammaglobulinemia of Infancy

MalaCards based summary : Transient Hypogammaglobulinemia of Infancy is related to transient hypogammaglobulinemia and immunoglobulin alpha deficiency. An important gene associated with Transient Hypogammaglobulinemia of Infancy is CD19 (CD19 Molecule), and among its related pathways/superpathways are NF-kappaB Signaling and Cytokine production by Th17 cells in CF (Mouse model). Affiliated tissues include b cells and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Transient hypogammaglobulinemia of infancy is a form of hypogammaglobulinemia appearing after birth,... more...

Related Diseases for Transient Hypogammaglobulinemia of Infancy

Diseases in the Transient Hypogammaglobulinemia family:

Congenital Hypogammaglobulinemia Transient Hypogammaglobulinemia of Infancy

Diseases related to Transient Hypogammaglobulinemia of Infancy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 transient hypogammaglobulinemia 30.5 CD19 TGFBR1 TGFBR2
2 immunoglobulin alpha deficiency 30.1 CD40LG CD79A
3 agammaglobulinemia 29.0 CD19 CD40LG CD79A
4 encephalitozoonosis 10.4 CD19 CD40LG
5 familial thoracic aortic aneurysm and dissection 10.2 TGFBR1 TGFBR2
6 loeys-dietz syndrome 1 10.2 TGFBR1 TGFBR2
7 eisenmenger syndrome 10.2 TGFBR1 TGFBR2
8 multiple self-healing squamous epithelioma 10.2 TGFBR1 TGFBR2
9 aortic aneurysm, familial thoracic 1 10.1 TGFBR1 TGFBR2
10 rhinoscleroma 10.0 CD19 CD79A
11 selective igg deficiency disease 10.0 CD40LG CD79A
12 c1q nephropathy 10.0 CD40LG CD79A
13 meningovascular neurosyphilis 10.0 CD40LG CD79A
14 alpha chain disease 10.0 CD40LG CD79A
15 brill-zinsser disease 10.0 CD40LG CD79A
16 exudative glomerulonephritis 10.0 CD40LG CD79A
17 cork-handlers' disease 10.0 CD40LG CD79A
18 salpingo-oophoritis 10.0 CD40LG CD79A
19 early yaws 10.0 CD40LG CD79A
20 ventilation pneumonitis 10.0 CD40LG CD79A
21 chronic interstitial cystitis 10.0 CD40LG CD79A
22 axillary adenitis 10.0 CD40LG CD79A
23 cryofibrinogenemia 10.0 CD40LG CD79A
24 trichostrongyloidiasis 10.0 CD40LG CD79A
25 subacute bacterial endocarditis 10.0 CD40LG CD79A
26 heterophyiasis 10.0 CD40LG CD79A
27 immunoglobulin g deficiency 10.0 CD40LG CD79A
28 orbital granuloma 10.0 CD40LG CD79A
29 hyperglobulinemic purpura 10.0 CD40LG CD79A
30 gastroduodenitis 10.0 CD40LG CD79A
31 bacterial conjunctivitis 10.0 CD40LG CD79A
32 heavy chain disease 10.0 CD40LG CD79A
33 ophthalmia neonatorum 10.0 CD40LG CD79A
34 dermatitis, atopic 10.0
35 dermatitis 10.0
36 immunoglobulin a deficiency 1 10.0 CD40LG CD79A
37 parotid disease 10.0 CD40LG CD79A
38 cerebral arteritis 10.0 CD40LG CD79A
39 small intestine lymphoma 10.0 CD19 CD79A
40 selective immunoglobulin deficiency disease 10.0 CD40LG CD79A
41 aortic disease 10.0 TGFBR1 TGFBR2
42 geniculate herpes zoster 10.0 CD40LG CD79A
43 erythema elevatum diutinum 10.0 CD40LG CD79A
44 sporotrichosis 10.0 CD40LG CD79A
45 anterior scleritis 10.0 CD19 CD79A
46 fallopian tube disease 10.0 CD40LG CD79A
47 hyperimmunoglobulin syndrome 10.0 CD40LG CD79A
48 congenital syphilis 10.0 CD40LG CD79A
49 polyclonal hypergammaglobulinemia 10.0 CD40LG CD79A
50 monoclonal paraproteinemia 10.0 CD40LG CD79A

Graphical network of the top 20 diseases related to Transient Hypogammaglobulinemia of Infancy:



Diseases related to Transient Hypogammaglobulinemia of Infancy

Symptoms & Phenotypes for Transient Hypogammaglobulinemia of Infancy

GenomeRNAi Phenotypes related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

26 (show all 25)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.77 TGFBR2 CD79A TGFBR1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.77 TGFBR2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.77 TGFBR2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.77 TGFBR2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.77 TGFBR2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.77 TGFBR2 TGFBR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.77 TGFBR2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.77 TGFBR2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.77 TGFBR2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.77 TGFBR1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.77 CD79A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.77 TGFBR2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.77 TGFBR2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.77 TGFBR2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.77 TGFBR1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.77 TGFBR1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.77 TGFBR2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.77 CD79A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.77 TGFBR2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.77 CD79A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.77 TGFBR2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.77 CD79A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.77 TGFBR2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.77 TGFBR1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.77 TGFBR1

MGI Mouse Phenotypes related to Transient Hypogammaglobulinemia of Infancy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.72 TGFBR1 TGFBR2 CD19 CD40LG CD79A
2 hematopoietic system MP:0005397 9.65 TGFBR1 TGFBR2 CD19 CD40LG CD79A
3 immune system MP:0005387 9.55 TGFBR1 TGFBR2 CD19 CD40LG CD79A
4 neoplasm MP:0002006 9.26 TGFBR2 CD19 CD79A TGFBR1
5 nervous system MP:0003631 9.02 TGFBR1 TGFBR2 CD19 CD40LG CD79A

Drugs & Therapeutics for Transient Hypogammaglobulinemia of Infancy

Search Clinical Trials , NIH Clinical Center for Transient Hypogammaglobulinemia of Infancy

Genetic Tests for Transient Hypogammaglobulinemia of Infancy

Anatomical Context for Transient Hypogammaglobulinemia of Infancy

MalaCards organs/tissues related to Transient Hypogammaglobulinemia of Infancy:

41
B Cells, T Cells

Publications for Transient Hypogammaglobulinemia of Infancy

Articles related to Transient Hypogammaglobulinemia of Infancy:

(show all 33)
# Title Authors Year
1
Transient hypogammaglobulinemia of infancy: predictive factors for late recovery. ( 27735798 )
2015
2
FcI^ receptor polymorphisms in patients with transient hypogammaglobulinemia of infancy presenting with mild and severe infections. ( 26708396 )
2015
3
Severe atopic dermatitis associated with transient hypogammaglobulinemia of infancy. ( 25600656 )
2015
4
Decreased IgM, IgA, and IgG response to pneumococcal vaccine in children with transient hypogammaglobulinemia of infancy. ( 26233927 )
2015
5
Does intravenous immunoglobulin therapy prolong immunodeficiency in transient hypogammaglobulinemia of infancy? ( 24198926 )
2013
6
The elevated number of circulating regulatory T cells in patients with transient hypogammaglobulinemia of infancy is not associated with any abnormalities in the genes encoding the TGF-I^ receptors. ( 23899993 )
2013
7
B-cell subsets in patients with transient hypogammaglobulinemia of infancy, partial IgA deficiency, and selective IgM deficiency. ( 23654075 )
2013
8
Reduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancy. ( 22820757 )
2013
9
The efficacy of Pelargonium sidoides in the treatment of upper respiratory tract infections in children with transient hypogammaglobulinemia of infancy. ( 22809962 )
2012
10
BCGitis in a Patient with Transient Hypogammaglobulinemia of Infancy. ( 23253103 )
2012
11
The number of circulating CD4+ CD25high Foxp3+ T lymphocytes is transiently elevated in the early childhood of transient hypogammaglobulinemia of infancy patients. ( 21531630 )
2011
12
New laboratory findings in Turkish patients with transient hypogammaglobulinemia of infancy. ( 21131704 )
2010
13
Transient hypogammaglobulinemia of infancy: intravenous immunoglobulin as first line therapy. ( 20378022 )
2010
14
Massive empyema associated with transient hypogammaglobulinemia of infancy and IgA deficiency. ( 19399287 )
2009
15
A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: results from the Italian Primary Immunodeficiency Network. ( 18547478 )
2008
16
Atopic dermatitis and transient hypogammaglobulinemia of infancy improved simultaneously. ( 17532847 )
2007
17
Impaired specific antibody response and increased B-cell population in transient hypogammaglobulinemia of infancy. ( 17165264 )
2006
18
Transient hypogammaglobulinemia of infancy presenting as Staphylococcus aureus sepsis with deep neck infection. ( 15843860 )
2005
19
Transient hypogammaglobulinemia of infancy and early childhood: outcome of 30 cases. ( 15214739 )
2004
20
Transient hypogammaglobulinemia of infancy: clinical and immunologic features of 40 new cases. ( 11192522 )
2000
21
X-linked agammaglobulinemia presenting as transient hypogammaglobulinemia of infancy. ( 7722175 )
1995
22
Absent specific viral antibodies in patients with transient hypogammaglobulinemia of infancy. ( 2303650 )
1990
23
Transient hypogammaglobulinemia of infancy. ( 2264470 )
1990
24
Transient hypogammaglobulinemia of infancy: Five new cases, review of the literature and redefinition. ( 2596283 )
1989
25
Transient hypogammaglobulinemia of infancy: need to reconsider name and definition. ( 3794886 )
1987
26
Streptococcal sepsis presenting as acute abdomen in a child with transient hypogammaglobulinemia of infancy. ( 3540263 )
1986
27
Transient hypogammaglobulinemia of infancy with severe bacterial infections and persistent IgA deficiency. ( 2427477 )
1986
28
Is transient hypogammaglobulinemia of infancy a manifestation of zinc deficiency? ( 6233190 )
1984
29
Transient hypogammaglobulinemia of infancy. ( 6977720 )
1982
30
Deficiency of T helper cells in transient hypogammaglobulinemia of infancy. ( 6270560 )
1981
31
Transient hypogammaglobulinemia of infancy: review of the literature, clinical and immunologic features of 11 new cases, and long-term follow-up. ( 632973 )
1978
32
Transient hypogammaglobulinemia of infancy. ( 75969 )
1978
33
Transient hypogammaglobulinemia of infancy. ( 908979 )
1977

Variations for Transient Hypogammaglobulinemia of Infancy

Expression for Transient Hypogammaglobulinemia of Infancy

Search GEO for disease gene expression data for Transient Hypogammaglobulinemia of Infancy.

Pathways for Transient Hypogammaglobulinemia of Infancy

Pathways related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1 12.12 CD19 CD40LG CD79A
2
Show member pathways
11.54 TGFBR1 TGFBR2
3 11.49 TGFBR1 TGFBR2
4
Show member pathways
11.44 TGFBR1 TGFBR2
5 11.4 TGFBR1 TGFBR2
6 11.39 TGFBR1 TGFBR2
7
Show member pathways
11.37 TGFBR1 TGFBR2
8 11.27 TGFBR1 TGFBR2
9 11.22 CD19 CD40LG
10 11.18 TGFBR1 TGFBR2
11 11.15 TGFBR1 TGFBR2
12
Show member pathways
10.95 TGFBR1 TGFBR2
13 10.88 TGFBR1 TGFBR2
14
Show member pathways
10.8 TGFBR1 TGFBR2
15 10.74 TGFBR1 TGFBR2
16 10.55 TGFBR1 TGFBR2
17 10.37 CD19 CD40LG CD79A
18 10.28 TGFBR1 TGFBR2

GO Terms for Transient Hypogammaglobulinemia of Infancy

Cellular components related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.56 CD19 CD40LG CD79A TGFBR2
2 membrane raft GO:0045121 9.33 CD79A TGFBR1 TGFBR2
3 transforming growth factor beta receptor complex GO:0070022 8.96 TGFBR1 TGFBR2
4 external side of plasma membrane GO:0009897 8.92 CD19 CD40LG CD79A TGFBR2

Biological processes related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 wound healing GO:0042060 9.56 TGFBR1 TGFBR2
2 roof of mouth development GO:0060021 9.55 TGFBR1 TGFBR2
3 signal transduction by protein phosphorylation GO:0023014 9.54 TGFBR1 TGFBR2
4 peptidyl-threonine phosphorylation GO:0018107 9.52 TGFBR1 TGFBR2
5 regulation of growth GO:0040008 9.51 TGFBR1 TGFBR2
6 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.49 TGFBR1 TGFBR2
7 B cell differentiation GO:0030183 9.48 CD40LG CD79A
8 positive regulation of epithelial to mesenchymal transition GO:0010718 9.46 TGFBR1 TGFBR2
9 lens development in camera-type eye GO:0002088 9.43 TGFBR1 TGFBR2
10 ventricular septum morphogenesis GO:0060412 9.4 TGFBR1 TGFBR2
11 embryonic cranial skeleton morphogenesis GO:0048701 9.37 TGFBR1 TGFBR2
12 B cell proliferation GO:0042100 9.32 CD40LG CD79A
13 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.26 TGFBR1 TGFBR2
14 pathway-restricted SMAD protein phosphorylation GO:0060389 9.16 TGFBR1 TGFBR2
15 response to cholesterol GO:0070723 8.96 TGFBR1 TGFBR2
16 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 8.62 TGFBR1 TGFBR2

Molecular functions related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD binding GO:0046332 9.32 TGFBR1 TGFBR2
2 transforming growth factor beta binding GO:0050431 9.26 TGFBR1 TGFBR2
3 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity GO:0004702 9.16 TGFBR1 TGFBR2
4 transmembrane receptor protein serine/threonine kinase activity GO:0004675 8.96 TGFBR1 TGFBR2
5 transforming growth factor beta-activated receptor activity GO:0005024 8.62 TGFBR1 TGFBR2

Sources for Transient Hypogammaglobulinemia of Infancy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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