MCID: TRN009
MIFTS: 31

Transient Hypogammaglobulinemia of Infancy

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Transient Hypogammaglobulinemia of Infancy

MalaCards integrated aliases for Transient Hypogammaglobulinemia of Infancy:

Name: Transient Hypogammaglobulinemia of Infancy 12 59 15

Classifications:

Orphanet: 59  
Rare immunological diseases


External Ids:

Disease Ontology 12 DOID:624
NCIt 50 C27071
SNOMED-CT 68 88714009
ICD10 33 D80.7
ICD10 via Orphanet 34 D80.7
UMLS via Orphanet 73 C0272238
Orphanet 59 ORPHA169139
UMLS 72 C0272238

Summaries for Transient Hypogammaglobulinemia of Infancy

MalaCards based summary : Transient Hypogammaglobulinemia of Infancy is related to transient hypogammaglobulinemia and immune deficiency disease. An important gene associated with Transient Hypogammaglobulinemia of Infancy is CD19 (CD19 Molecule), and among its related pathways/superpathways are PEDF Induced Signaling and PAK Pathway. Affiliated tissues include b cells and t cells, and related phenotypes are cellular and hematopoietic system

Wikipedia : 75 Transient hypogammaglobulinemia of infancy is a form of hypogammaglobulinemia appearing after birth,... more...

Related Diseases for Transient Hypogammaglobulinemia of Infancy

Diseases in the Transient Hypogammaglobulinemia family:

Congenital Hypogammaglobulinemia Transient Hypogammaglobulinemia of Infancy

Diseases related to Transient Hypogammaglobulinemia of Infancy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 transient hypogammaglobulinemia 30.5 TGFBR2 TGFBR1 CD19
2 immune deficiency disease 29.3 CD40LG CD19
3 common variable immunodeficiency 29.2 CD40LG CD27 CD19
4 tetanus 29.1 CD40LG CD27
5 agammaglobulinemia 10.8
6 immunoglobulin alpha deficiency 10.2
7 ige responsiveness, atopic 10.1
8 otitis media 10.1
9 agammaglobulinemia, x-linked 10.1
10 dermatitis, atopic 10.1
11 diphtheria 10.1
12 dermatitis 10.1
13 bronchitis 10.1
14 haemophilus influenzae 10.1
15 solitary osseous plasmacytoma 10.1 CD27 CD19
16 familial thoracic aortic aneurysm and dissection 10.0 TGFBR2 TGFBR1
17 aortic aneurysm 10.0 TGFBR2 TGFBR1
18 cutis laxa, autosomal recessive, type ic 10.0 TGFBR2 TGFBR1
19 autoimmune disease 10.0
20 autoimmune disease 4 10.0
21 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
22 hydrops, lactic acidosis, and sideroblastic anemia 10.0
23 bacterial infectious disease 10.0
24 dysgammaglobulinemia 10.0
25 gastroenteritis 10.0
26 pleural empyema 10.0
27 measles 10.0
28 rubella 10.0
29 loeys-dietz syndrome 4 10.0 TGFBR2 TGFBR1
30 loeys-dietz syndrome 10.0 TGFBR2 TGFBR1
31 multiple self-healing squamous epithelioma 9.9 TGFBR2 TGFBR1
32 autosomal recessive cutis laxa type i 9.9 TGFBR2 TGFBR1
33 eisenmenger syndrome 9.9 TGFBR2 TGFBR1
34 loeys-dietz syndrome 3 9.9 TGFBR2 TGFBR1
35 aortic aneurysm, familial thoracic 1 9.9 TGFBR2 TGFBR1
36 loeys-dietz syndrome 1 9.8 TGFBR2 TGFBR1
37 aortic disease 9.7 TGFBR2 TGFBR1
38 lymphoproliferative syndrome 2 9.7 CD40LG CD27
39 autoimmune disease of musculoskeletal system 9.6 CD40LG CD19
40 cryoglobulinemia 9.6 CD40LG CD27
41 macroglobulinemia 9.6 CD40LG CD27
42 marfan syndrome 9.6 TGFBR2 TGFBR1
43 b cell deficiency 9.4 CD40LG CD27 CD19
44 leukemia, chronic lymphocytic 9.3 CD40LG CD27 CD19

Graphical network of the top 20 diseases related to Transient Hypogammaglobulinemia of Infancy:



Diseases related to Transient Hypogammaglobulinemia of Infancy

Symptoms & Phenotypes for Transient Hypogammaglobulinemia of Infancy

MGI Mouse Phenotypes related to Transient Hypogammaglobulinemia of Infancy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.55 CD19 CD27 CD40LG TGFBR1 TGFBR2
2 hematopoietic system MP:0005397 9.35 CD19 CD27 CD40LG TGFBR1 TGFBR2
3 immune system MP:0005387 9.02 CD19 CD27 CD40LG TGFBR1 TGFBR2

Drugs & Therapeutics for Transient Hypogammaglobulinemia of Infancy

Search Clinical Trials , NIH Clinical Center for Transient Hypogammaglobulinemia of Infancy

Genetic Tests for Transient Hypogammaglobulinemia of Infancy

Anatomical Context for Transient Hypogammaglobulinemia of Infancy

MalaCards organs/tissues related to Transient Hypogammaglobulinemia of Infancy:

41
B Cells, T Cells

Publications for Transient Hypogammaglobulinemia of Infancy

Articles related to Transient Hypogammaglobulinemia of Infancy:

(show top 50) (show all 63)
# Title Authors PMID Year
1
B lymphocyte subsets and outcomes in patients with an initial diagnosis of transient hypogammaglobulinemia of infancy. 38
30152873 2018
2
[Transient hypogammaglobulinemia of infancy]. 38
28722362 2017
3
Decreased IgM, IgA, and IgG response to pneumococcal vaccine in children with transient hypogammaglobulinemia of infancy. 38
26233927 2016
4
Transient hypogammaglobulinemia and severe atopic dermatitis: Open-label treatment with immunoglobulin in a case series. 38
27470901 2016
5
Fcγ receptor polymorphisms in patients with transient hypogammaglobulinemia of infancy presenting with mild and severe infections. 38
26708396 2015
6
Transient hypogammaglobulinemia of infancy: predictive factors for late recovery. 38
27735798 2015
7
Severe atopic dermatitis associated with transient hypogammaglobulinemia of infancy. 38
25600656 2015
8
BCGitis in a patient with transient hypogammaglobulinemia of infancy. 38
23253103 2014
9
Quality of life in children with primary antibody deficiency. 38
25005831 2014
10
Primary antibody deficiencies at Queen Rania Children Hospital in Jordan: single center experience. 38
24632588 2014
11
Phenotypic parameters predict time to normalization in infants with hypogammaglobulinemia. 38
24014079 2013
12
Reduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancy. 38
22820757 2013
13
The elevated number of circulating regulatory T cells in patients with transient hypogammaglobulinemia of infancy is not associated with any abnormalities in the genes encoding the TGF-β receptors. 38
23899993 2013
14
Severe parainfluenza pneumonia in a case of transient hypogammalobulinemia of infancy. 38
23814123 2013
15
B-cell subsets in patients with transient hypogammaglobulinemia of infancy, partial IgA deficiency, and selective IgM deficiency. 38
23654075 2013
16
Does intravenous immunoglobulin therapy prolong immunodeficiency in transient hypogammaglobulinemia of infancy? 38
24198926 2013
17
Primary Immunodeficiency May Be Misdiagnosed as Cow's Milk Allergy: Seven Cases Referred to a Tertiary Pediatric Hospital. 38
24198970 2013
18
The efficacy of Pelargonium sidoides in the treatment of upper respiratory tract infections in children with transient hypogammaglobulinemia of infancy. 38
22809962 2012
19
The number of circulating CD4+ CD25high Foxp3+ T lymphocytes is transiently elevated in the early childhood of transient hypogammaglobulinemia of infancy patients. 38
21531630 2011
20
Study of patients with Hyper-IgM type IV phenotype who recovered spontaneously during late childhood and review of the literature. 38
21274562 2011
21
TNFRSF13B/TACI alterations in Greek patients with antibody deficiencies. 38
21547394 2011
22
New laboratory findings in Turkish patients with transient hypogammaglobulinemia of infancy. 38
21131704 2010
23
Infants with low immunoglobulin levels: Isolated low IgA level vs other immunoglobulin abnormalities. 38
20934629 2010
24
Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: 'similarities and differences'. 38
20609138 2010
25
Transient hypogammaglobulinemia of infancy: intravenous immunoglobulin as first line therapy. 38
20378022 2010
26
Clinical features and follow-up of Chinese patients with symptomatic hypogammaglobulinemia in infancy. 38
19781364 2009
27
The B-cell compartment in the peripheral blood of children with different types of primary humoral immunodeficiency. 38
19342988 2009
28
Massive empyema associated with transient hypogammaglobulinemia of infancy and IgA deficiency. 38
19399287 2009
29
A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: results from the Italian Primary Immunodeficiency Network. 38
18547478 2008
30
Atopic dermatitis and transient hypogammaglobulinemia of infancy improved simultaneously. 38
17532847 2007
31
Two children with invasive gastrointestinal aspergillosis. 38
17536141 2007
32
The four most common pediatric immunodeficiencies. 38
17712988 2007
33
Impaired specific antibody response and increased B-cell population in transient hypogammaglobulinemia of infancy. 38
17165264 2006
34
Infants presenting with recurrent infections and low immunoglobulins: characteristics and analysis of normalization. 38
16418798 2006
35
Transient hypogammaglobulinemia of infancy presenting as Staphylococcus aureus sepsis with deep neck infection. 38
15843860 2005
36
Symptomatic hypogammaglobulinemia in infancy and childhood - clinical outcome and in vitro immune responses. 38
15498106 2004
37
Transient hypogammaglobulinemia of infancy and early childhood: outcome of 30 cases. 38
15214739 2004
38
Immunological and clinical features of pediatric patients with primary hypogammaglobulinemia in Taiwan. 38
15366655 2004
39
A case of IgG subclass deficiency with the initial presentation of transient hypogammaimmuno-globulinemia of infancy and a review of IgG subclass deficiencies. 38
12948264 2003
40
Spontaneous resolution of profound hypogammaglobulinemia. 38
11811863 2001
41
Transient hypogammaglobulinemia of infancy: clinical and immunologic features of 40 new cases. 38
11192522 2000
42
[Transient hypogammaglobulinemia of infancy]. 38
11212827 2000
43
[Cytokines in children with immunodeficiencies]. 38
10909468 1999
44
[Transient hypogammaglobulinemia of infancy]. 38
9833468 1998
45
Cytokine production in transient hypogammaglobulinemia and isolated IgA deficiency. 38
9338552 1997
46
X-linked agammaglobulinemia presenting as transient hypogammaglobulinemia of infancy. 38
7722175 1995
47
Positive role of Clostridium difficile infection in diarrhea in infants and children. 38
2038989 1991
48
Transient hypogammaglobulinemia of infancy. 38
2264470 1990
49
Absent specific viral antibodies in patients with transient hypogammaglobulinemia of infancy. 38
2303650 1990
50
Transient hypogammaglobulinemia of infancy: Five new cases, review of the literature and redefinition. 38
2596283 1989

Variations for Transient Hypogammaglobulinemia of Infancy

Expression for Transient Hypogammaglobulinemia of Infancy

Search GEO for disease gene expression data for Transient Hypogammaglobulinemia of Infancy.

Pathways for Transient Hypogammaglobulinemia of Infancy

Pathways related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.26 TGFBR2 TGFBR1 CD40LG CD27
2
Show member pathways
12.77 TGFBR2 TGFBR1 CD40LG CD27
3
Show member pathways
11.74 TGFBR2 TGFBR1
4 11.72 TGFBR2 TGFBR1
5 11.6 TGFBR2 TGFBR1
6 11.57 TGFBR2 TGFBR1
7
Show member pathways
11.55 TGFBR2 TGFBR1
8 11.55 TGFBR2 TGFBR1
9
Show member pathways
11.45 TGFBR2 TGFBR1
10 11.42 TGFBR2 TGFBR1
11 11.4 TGFBR2 TGFBR1
12
Show member pathways
11.38 TGFBR2 TGFBR1
13
Show member pathways
11.3 TGFBR2 TGFBR1
14 11.29 TGFBR2 TGFBR1
15 11.27 CD40LG CD27
16 11.2 TGFBR2 TGFBR1
17 11.17 TGFBR2 TGFBR1
18 11.11 TGFBR2 TGFBR1
19 11 CD40LG CD19
20 10.85 TGFBR2 TGFBR1
21
Show member pathways
10.75 TGFBR2 TGFBR1
22 10.67 TGFBR2 TGFBR1
23 10.55 TGFBR2 TGFBR1
24 10.52 CD40LG CD27 CD19
25 10.28 TGFBR2 TGFBR1

GO Terms for Transient Hypogammaglobulinemia of Infancy

Cellular components related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.46 TGFBR2 TGFBR1 CD40LG CD27
2 integral component of plasma membrane GO:0005887 9.35 TGFBR2 TGFBR1 CD40LG CD27 CD19
3 external side of plasma membrane GO:0009897 8.92 TGFBR2 CD40LG CD27 CD19

Biological processes related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.74 TGFBR2 TGFBR1 CD27
2 negative regulation of apoptotic process GO:0043066 9.71 TGFBR1 CD40LG CD27
3 transforming growth factor beta receptor signaling pathway GO:0007179 9.56 TGFBR2 TGFBR1
4 wound healing GO:0042060 9.55 TGFBR2 TGFBR1
5 regulation of growth GO:0040008 9.52 TGFBR2 TGFBR1
6 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.51 TGFBR2 TGFBR1
7 tumor necrosis factor-mediated signaling pathway GO:0033209 9.49 CD40LG CD27
8 pattern specification process GO:0007389 9.48 TGFBR2 TGFBR1
9 peptidyl-threonine phosphorylation GO:0018107 9.46 TGFBR2 TGFBR1
10 positive regulation of epithelial to mesenchymal transition GO:0010718 9.43 TGFBR2 TGFBR1
11 ventricular septum morphogenesis GO:0060412 9.4 TGFBR2 TGFBR1
12 lens development in camera-type eye GO:0002088 9.37 TGFBR2 TGFBR1
13 embryonic cranial skeleton morphogenesis GO:0048701 9.32 TGFBR2 TGFBR1
14 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.26 TGFBR2 TGFBR1
15 pathway-restricted SMAD protein phosphorylation GO:0060389 9.16 TGFBR2 TGFBR1
16 response to cholesterol GO:0070723 8.96 TGFBR2 TGFBR1
17 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 8.62 TGFBR2 TGFBR1

Molecular functions related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD binding GO:0046332 9.32 TGFBR2 TGFBR1
2 growth factor binding GO:0019838 9.26 TGFBR2 TGFBR1
3 transforming growth factor beta binding GO:0050431 9.16 TGFBR2 TGFBR1
4 transforming growth factor beta-activated receptor activity GO:0005024 8.96 TGFBR2 TGFBR1
5 transmembrane receptor protein serine/threonine kinase activity GO:0004675 8.62 TGFBR2 TGFBR1

Sources for Transient Hypogammaglobulinemia of Infancy

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
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33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
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73 UMLS via Orphanet
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