MCID: TRN009
MIFTS: 32

Transient Hypogammaglobulinemia of Infancy

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Transient Hypogammaglobulinemia of Infancy

MalaCards integrated aliases for Transient Hypogammaglobulinemia of Infancy:

Name: Transient Hypogammaglobulinemia of Infancy 12 58 15

Classifications:

Orphanet: 58  
Rare immunological diseases


External Ids:

Disease Ontology 12 DOID:624
NCIt 49 C27071
SNOMED-CT 67 88714009
ICD10 32 D80.7
ICD10 via Orphanet 33 D80.7
UMLS via Orphanet 72 C0272238
Orphanet 58 ORPHA169139
UMLS 71 C0272238

Summaries for Transient Hypogammaglobulinemia of Infancy

MalaCards based summary : Transient Hypogammaglobulinemia of Infancy is related to agammaglobulinemia and dysgammaglobulinemia. An important gene associated with Transient Hypogammaglobulinemia of Infancy is CD19 (CD19 Molecule), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include b cells and t cells, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 Transient hypogammaglobulinemia of infancy is a form of hypogammaglobulinemia appearing after birth,... more...

Related Diseases for Transient Hypogammaglobulinemia of Infancy

Diseases in the Transient Hypogammaglobulinemia family:

Congenital Hypogammaglobulinemia Transient Hypogammaglobulinemia of Infancy

Diseases related to Transient Hypogammaglobulinemia of Infancy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 agammaglobulinemia 30.0 CR2 CD40LG CD19 BTK
2 dysgammaglobulinemia 30.0 TNFRSF13B CD40LG
3 transient hypogammaglobulinemia 29.7 TGFBR2 TGFBR1 RNU4ATAC CD40LG CD19 BTK
4 immunoglobulin alpha deficiency 28.8 TNFRSF13B CD40LG CD27 CD19 BTK
5 immune deficiency disease 27.9 TNFRSF13B CR2 CD40LG CD27 BTK
6 common variable immunodeficiency 27.8 TNFRSF13B CR2 CD40LG CD27 CD19 BTK
7 tricuspid valve prolapse 10.3 TGFBR2 TGFBR1
8 eisenmenger syndrome 10.3 TGFBR2 TGFBR1
9 loeys-dietz syndrome 5 10.3 TGFBR2 TGFBR1
10 heritable thoracic aortic disease 10.3 TGFBR2 TGFBR1
11 pulsating exophthalmos 10.3 TGFBR2 TGFBR1
12 multiple self-healing squamous epithelioma 10.2 TGFBR2 TGFBR1
13 monoclonal paraproteinemia 10.2 CD40LG CD19
14 loeys-dietz syndrome 3 10.2 TGFBR2 TGFBR1
15 cerebral lymphoma 10.2 CD40LG CD19
16 loeys-dietz syndrome 4 10.2 TGFBR2 TGFBR1
17 tetanus 10.2
18 arterial tortuosity syndrome 10.2 TGFBR2 TGFBR1
19 adenoid hypertrophy 10.2 CD40LG CD19
20 alpha chain disease 10.2 CD40LG CD19
21 aortic valve insufficiency 10.2 TGFBR2 TGFBR1
22 ige responsiveness, atopic 10.1
23 otitis media 10.1
24 agammaglobulinemia, x-linked 10.1
25 dermatitis, atopic 10.1
26 diphtheria 10.1
27 dermatitis 10.1
28 bronchitis 10.1
29 haemophilus influenzae 10.1
30 primary thrombocytopenia 10.1 CD40LG CD19
31 loeys-dietz syndrome 1 10.1 TGFBR2 TGFBR1
32 cll/sll 10.1 CD19 BTK
33 autoimmune disease of blood 10.1 CD40LG CD19
34 isolated growth hormone deficiency type iii 10.1 CD40LG BTK
35 anemia, autoimmune hemolytic 10.1 CD40LG CD19
36 immunodeficiency with hyper-igm, type 1 10.1 CD40LG BTK
37 immunodeficiency with hyper-igm, type 5 10.1 TNFRSF13B CD40LG
38 selective immunoglobulin deficiency disease 10.0 TNFRSF13B CD40LG
39 immunodeficiency with hyper-igm, type 3 10.0 TNFRSF13B CD40LG
40 immunodeficiency with hyper-igm, type 4 10.0 CD40LG CD27
41 immunodeficiency with hyper-igm, type 2 10.0 TNFRSF13B CD40LG
42 plasma cell neoplasm 10.0 CD40LG CD19
43 autoimmune disease 10.0
44 autoimmune disease 4 10.0
45 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
46 hydrops, lactic acidosis, and sideroblastic anemia 10.0
47 bacterial infectious disease 10.0
48 gastroenteritis 10.0
49 pleural empyema 10.0
50 measles 10.0

Graphical network of the top 20 diseases related to Transient Hypogammaglobulinemia of Infancy:



Diseases related to Transient Hypogammaglobulinemia of Infancy

Symptoms & Phenotypes for Transient Hypogammaglobulinemia of Infancy

MGI Mouse Phenotypes related to Transient Hypogammaglobulinemia of Infancy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.86 BTK CD19 CD27 CD40LG CR2 TGFBR1
2 immune system MP:0005387 9.76 BTK CD19 CD27 CD40LG CR2 TGFBR1
3 neoplasm MP:0002006 9.35 BTK CD19 TGFBR1 TGFBR2 TNFRSF13B
4 renal/urinary system MP:0005367 9.02 CD19 CD40LG CR2 TGFBR2 TNFRSF13B

Drugs & Therapeutics for Transient Hypogammaglobulinemia of Infancy

Search Clinical Trials , NIH Clinical Center for Transient Hypogammaglobulinemia of Infancy

Genetic Tests for Transient Hypogammaglobulinemia of Infancy

Anatomical Context for Transient Hypogammaglobulinemia of Infancy

MalaCards organs/tissues related to Transient Hypogammaglobulinemia of Infancy:

40
B Cells, T Cells

Publications for Transient Hypogammaglobulinemia of Infancy

Articles related to Transient Hypogammaglobulinemia of Infancy:

(show top 50) (show all 64)
# Title Authors PMID Year
1
Diagnostic approach of hypogammaglobulinemia in infancy. 61
32017208 2020
2
B lymphocyte subsets and outcomes in patients with an initial diagnosis of transient hypogammaglobulinemia of infancy. 61
30152873 2018
3
[Transient hypogammaglobulinemia of infancy]. 61
28722362 2017
4
Decreased IgM, IgA, and IgG response to pneumococcal vaccine in children with transient hypogammaglobulinemia of infancy. 61
26233927 2016
5
Transient hypogammaglobulinemia and severe atopic dermatitis: Open-label treatment with immunoglobulin in a case series. 61
27470901 2016
6
Fcγ receptor polymorphisms in patients with transient hypogammaglobulinemia of infancy presenting with mild and severe infections. 61
26708396 2015
7
Transient hypogammaglobulinemia of infancy: predictive factors for late recovery. 61
27735798 2015
8
Severe atopic dermatitis associated with transient hypogammaglobulinemia of infancy. 61
25600656 2015
9
BCGitis in a patient with transient hypogammaglobulinemia of infancy. 61
23253103 2014
10
Quality of life in children with primary antibody deficiency. 61
25005831 2014
11
Primary antibody deficiencies at Queen Rania Children Hospital in Jordan: single center experience. 61
24632588 2014
12
Phenotypic parameters predict time to normalization in infants with hypogammaglobulinemia. 61
24014079 2013
13
Reduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancy. 61
22820757 2013
14
The elevated number of circulating regulatory T cells in patients with transient hypogammaglobulinemia of infancy is not associated with any abnormalities in the genes encoding the TGF-β receptors. 61
23899993 2013
15
Severe parainfluenza pneumonia in a case of transient hypogammalobulinemia of infancy. 61
23814123 2013
16
B-cell subsets in patients with transient hypogammaglobulinemia of infancy, partial IgA deficiency, and selective IgM deficiency. 61
23654075 2013
17
Does intravenous immunoglobulin therapy prolong immunodeficiency in transient hypogammaglobulinemia of infancy? 61
24198926 2013
18
Primary Immunodeficiency May Be Misdiagnosed as Cow's Milk Allergy: Seven Cases Referred to a Tertiary Pediatric Hospital. 61
24198970 2013
19
The efficacy of Pelargonium sidoides in the treatment of upper respiratory tract infections in children with transient hypogammaglobulinemia of infancy. 61
22809962 2012
20
The number of circulating CD4+ CD25high Foxp3+ T lymphocytes is transiently elevated in the early childhood of transient hypogammaglobulinemia of infancy patients. 61
21531630 2011
21
Study of patients with Hyper-IgM type IV phenotype who recovered spontaneously during late childhood and review of the literature. 61
21274562 2011
22
TNFRSF13B/TACI alterations in Greek patients with antibody deficiencies. 61
21547394 2011
23
New laboratory findings in Turkish patients with transient hypogammaglobulinemia of infancy. 61
21131704 2010
24
Infants with low immunoglobulin levels: Isolated low IgA level vs other immunoglobulin abnormalities. 61
20934629 2010
25
Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: 'similarities and differences'. 61
20609138 2010
26
Transient hypogammaglobulinemia of infancy: intravenous immunoglobulin as first line therapy. 61
20378022 2010
27
Clinical features and follow-up of Chinese patients with symptomatic hypogammaglobulinemia in infancy. 61
19781364 2009
28
The B-cell compartment in the peripheral blood of children with different types of primary humoral immunodeficiency. 61
19342988 2009
29
Massive empyema associated with transient hypogammaglobulinemia of infancy and IgA deficiency. 61
19399287 2009
30
A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: results from the Italian Primary Immunodeficiency Network. 61
18547478 2008
31
Atopic dermatitis and transient hypogammaglobulinemia of infancy improved simultaneously. 61
17532847 2007
32
Two children with invasive gastrointestinal aspergillosis. 61
17536141 2007
33
The four most common pediatric immunodeficiencies. 61
17712988 2007
34
Impaired specific antibody response and increased B-cell population in transient hypogammaglobulinemia of infancy. 61
17165264 2006
35
Infants presenting with recurrent infections and low immunoglobulins: characteristics and analysis of normalization. 61
16418798 2006
36
Transient hypogammaglobulinemia of infancy presenting as Staphylococcus aureus sepsis with deep neck infection. 61
15843860 2005
37
Symptomatic hypogammaglobulinemia in infancy and childhood - clinical outcome and in vitro immune responses. 61
15498106 2004
38
Transient hypogammaglobulinemia of infancy and early childhood: outcome of 30 cases. 61
15214739 2004
39
Immunological and clinical features of pediatric patients with primary hypogammaglobulinemia in Taiwan. 61
15366655 2004
40
A case of IgG subclass deficiency with the initial presentation of transient hypogammaimmuno-globulinemia of infancy and a review of IgG subclass deficiencies. 61
12948264 2003
41
Spontaneous resolution of profound hypogammaglobulinemia. 61
11811863 2001
42
Transient hypogammaglobulinemia of infancy: clinical and immunologic features of 40 new cases. 61
11192522 2000
43
[Transient hypogammaglobulinemia of infancy]. 61
11212827 2000
44
[Cytokines in children with immunodeficiencies]. 61
10909468 1999
45
[Transient hypogammaglobulinemia of infancy]. 61
9833468 1998
46
Cytokine production in transient hypogammaglobulinemia and isolated IgA deficiency. 61
9338552 1997
47
X-linked agammaglobulinemia presenting as transient hypogammaglobulinemia of infancy. 61
7722175 1995
48
Positive role of Clostridium difficile infection in diarrhea in infants and children. 61
2038989 1991
49
Transient hypogammaglobulinemia of infancy. 61
2264470 1990
50
Absent specific viral antibodies in patients with transient hypogammaglobulinemia of infancy. 61
2303650 1990

Variations for Transient Hypogammaglobulinemia of Infancy

Expression for Transient Hypogammaglobulinemia of Infancy

Search GEO for disease gene expression data for Transient Hypogammaglobulinemia of Infancy.

Pathways for Transient Hypogammaglobulinemia of Infancy

Pathways related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.42 TNFRSF13B TGFBR2 TGFBR1 CD40LG CD27 BTK
2
Show member pathways
13.19 TNFRSF13B TGFBR2 TGFBR1 CD40LG CD27 BTK
3
Show member pathways
13.07 TNFRSF13B TGFBR1 CD40LG CD27 BTK
4
Show member pathways
12.7 TNFRSF13B TGFBR2 TGFBR1 CD40LG CD27 BTK
5
Show member pathways
12.11 CR2 CD19 BTK
6 11.54 TGFBR2 TGFBR1 BTK
7 11.25 TGFBR2 TGFBR1
8 11.2 TGFBR2 TGFBR1
9 10.99 TNFRSF13B CD27
10 10.97 TGFBR2 TGFBR1
11
Show member pathways
10.89 TGFBR2 TGFBR1
12 10.85 TGFBR2 TGFBR1
13 10.84 TNFRSF13B CD40LG CD19 BTK
14 10.8 TGFBR2 TGFBR1
15 10.75 TNFRSF13B CR2 CD40LG CD27 CD19
16 10.64 TGFBR2 TGFBR1

GO Terms for Transient Hypogammaglobulinemia of Infancy

Cellular components related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.77 TNFRSF13B TGFBR2 CD40LG CD27 CD19
2 plasma membrane GO:0005886 9.76 TNFRSF13B TGFBR2 TGFBR1 CR2 CD40LG CD27
3 cell surface GO:0009986 9.62 TGFBR2 TGFBR1 CD40LG CD27
4 receptor complex GO:0043235 9.43 TGFBR2 TGFBR1 CR2
5 external side of plasma membrane GO:0009897 9.26 TGFBR2 CD40LG CD27 CD19
6 membrane raft GO:0045121 8.92 TGFBR2 TGFBR1 CD19 BTK

Biological processes related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.8 TGFBR2 TGFBR1 CD27 BTK
2 immune system process GO:0002376 9.78 TNFRSF13B CR2 CD19 BTK
3 positive regulation of epithelial to mesenchymal transition GO:0010718 9.56 TGFBR2 TGFBR1
4 lens development in camera-type eye GO:0002088 9.55 TGFBR2 TGFBR1
5 ventricular septum morphogenesis GO:0060412 9.54 TGFBR2 TGFBR1
6 B cell proliferation GO:0042100 9.52 CR2 CD40LG
7 embryonic cranial skeleton morphogenesis GO:0048701 9.51 TGFBR2 TGFBR1
8 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.46 TGFBR2 TGFBR1
9 activin receptor signaling pathway GO:0032924 9.43 TGFBR2 TGFBR1
10 negative regulation of B cell proliferation GO:0030889 9.4 TNFRSF13B BTK
11 pathway-restricted SMAD protein phosphorylation GO:0060389 9.37 TGFBR2 TGFBR1
12 tumor necrosis factor-mediated signaling pathway GO:0033209 9.33 TNFRSF13B CD40LG CD27
13 positive regulation of B cell differentiation GO:0045579 9.32 CD27 BTK
14 immunoglobulin mediated immune response GO:0016064 9.26 CD27 CD19
15 response to cholesterol GO:0070723 8.96 TGFBR2 TGFBR1
16 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 8.62 TGFBR2 TGFBR1

Molecular functions related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta binding GO:0050431 9.26 TGFBR2 TGFBR1
2 activin binding GO:0048185 9.16 TGFBR2 TGFBR1
3 transmembrane receptor protein serine/threonine kinase activity GO:0004675 8.96 TGFBR2 TGFBR1
4 transforming growth factor beta-activated receptor activity GO:0005024 8.62 TGFBR2 TGFBR1

Sources for Transient Hypogammaglobulinemia of Infancy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....