MCID: TRN009
MIFTS: 38

Transient Hypogammaglobulinemia of Infancy

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Transient Hypogammaglobulinemia of Infancy

MalaCards integrated aliases for Transient Hypogammaglobulinemia of Infancy:

Name: Transient Hypogammaglobulinemia of Infancy 12 60 15

Classifications:

Orphanet: 60  
Rare immunological diseases


External Ids:

Disease Ontology 12 DOID:624
NCIt 51 C27071
SNOMED-CT 69 88714009
ICD10 34 D80.7
ICD10 via Orphanet 35 D80.7
UMLS via Orphanet 75 C0272238
Orphanet 60 ORPHA169139
UMLS 74 C0272238

Summaries for Transient Hypogammaglobulinemia of Infancy

MalaCards based summary : Transient Hypogammaglobulinemia of Infancy is related to agammaglobulinemia and transient hypogammaglobulinemia. An important gene associated with Transient Hypogammaglobulinemia of Infancy is CD19 (CD19 Molecule), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include b cells and t cells, and related phenotypes are hematopoietic system and immune system

Wikipedia : 77 Transient hypogammaglobulinemia of infancy is a form of hypogammaglobulinemia appearing after birth,... more...

Related Diseases for Transient Hypogammaglobulinemia of Infancy

Diseases in the Transient Hypogammaglobulinemia family:

Congenital Hypogammaglobulinemia Transient Hypogammaglobulinemia of Infancy

Diseases related to Transient Hypogammaglobulinemia of Infancy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 agammaglobulinemia 31.3 BTK CD19 CR2
2 transient hypogammaglobulinemia 30.9 CD19 IL10 LTA TGFBR1 TGFBR2
3 agammaglobulinemia, x-linked 29.8 BTK CD40 CD40LG
4 familial thoracic aortic aneurysm and dissection 10.4 TGFBR1 TGFBR2
5 lobomycosis 10.3 CD19 CR2
6 cutis laxa, autosomal recessive, type ic 10.3 TGFBR1 TGFBR2
7 congenital rubella 10.3 CD40LG UNG
8 loeys-dietz syndrome 4 10.3 TGFBR1 TGFBR2
9 immunodeficiency, common variable, 2 10.3 CD19 CR2 TNFRSF13B
10 cephalosporin allergy 10.2 IL10 TGFBR1
11 immunoglobulin alpha deficiency 10.2
12 bladder lymphoma 10.2 CD19 CR2
13 light fixation seizure syndrome 10.1 CD40 CD40LG
14 leukocyte disease 10.1 CD19 CR2 IL4
15 sporotrichosis 10.1 CD40LG IL10
16 dermatitis, atopic 10.1
17 dermatitis 10.1
18 tropical endomyocardial fibrosis 10.1 IL10 IL4
19 endomyocardial fibrosis 10.1 IL10 IL4
20 congenital hypogammaglobulinemia 10.1 BTK CD19 IL4
21 cryoglobulinemia 10.1 CD27 CD40LG CD81 CR2
22 tungiasis 10.0 IL10 IL4
23 nickel allergic contact dermatitis 10.0 IL10 IL4
24 ascaridiasis 10.0 IL10 NELFCD
25 immunodeficiency with hyper-igm, type 4 10.0 CD40 CD40LG UNG
26 cd40 ligand deficiency 10.0 CD40 CD40LG UNG
27 hyperimmunoglobulin syndrome 10.0 CD40 CD40LG UNG
28 macroglobulinemia 10.0 BTK CD27 CD40LG TNFRSF13B
29 immunoglobulin a deficiency 1 10.0 BTK CD40LG LTA TNFRSF13B
30 hemophagocytic lymphohistiocytosis 10.0 CD27 CR2 IL10
31 retinitis pigmentosa 22 10.0 IL10 IL4
32 immunodeficiency with hyper-igm, type 2 10.0 CD40 CD40LG UNG
33 idiopathic achalasia 10.0 IL10 LTA
34 bacterial infectious disease 10.0
35 pleural empyema 10.0
36 baylisascariasis 10.0 IL10 IL4
37 toxic shock syndrome 9.9 IL10 IL4 LTA
38 brucellosis 9.9 CD40LG IL10 IL4
39 rubella 9.9 CD40LG IL10 IL4
40 waldenstrom macroglobulinemia 9.9 BTK CD40 CD40LG
41 poliomyelitis 9.9 BTK IL10 IL4
42 sulfamethoxazole allergy 9.9 CD40 CD40LG IL4
43 schistosomiasis 9.9 CD40LG IL10 IL4
44 autoimmune disease of musculoskeletal system 9.8 CD19 CD40LG IL10 IL4
45 hyperlucent lung 9.8 IL10 IL4 NELFCD
46 chromoblastomycosis 9.8 CCR1 IL4
47 mantle cell lymphoma 9.8 BTK CD19 CD40
48 viral infectious disease 9.8 CD40LG CD81 IL10 IL4
49 lymphoma, non-hodgkin, familial 9.8 CD19 CD27 CD40 CR2 TNFRSF13B
50 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.7 BTK CD40LG IL10 IL4

Graphical network of the top 20 diseases related to Transient Hypogammaglobulinemia of Infancy:



Diseases related to Transient Hypogammaglobulinemia of Infancy

Symptoms & Phenotypes for Transient Hypogammaglobulinemia of Infancy

MGI Mouse Phenotypes related to Transient Hypogammaglobulinemia of Infancy:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.4 BTK CCR1 CD19 CD27 CD40 CD40LG
2 immune system MP:0005387 10.36 BTK CCR1 CD19 CD27 CD40 CD40LG
3 homeostasis/metabolism MP:0005376 10.35 BTK CCR1 CD19 CD40 CD40LG CD81
4 cellular MP:0005384 10.24 BTK CCR1 CD19 CD27 CD40LG IL10
5 mortality/aging MP:0010768 10.18 BTK CCR1 CD19 CD40LG CR2 IL10
6 endocrine/exocrine gland MP:0005379 10.11 CD40 CD40LG IL10 IL4 LTA TGFBR1
7 digestive/alimentary MP:0005381 10.07 BTK CCR1 CD19 IL10 IL4 TGFBR1
8 nervous system MP:0003631 10.02 CD19 CD40 CD40LG CD81 IL10 IL4
9 liver/biliary system MP:0005370 9.98 CCR1 CD19 IL10 IL4 LTA TGFBR2
10 neoplasm MP:0002006 9.91 BTK CD19 IL10 TGFBR1 TGFBR2 TNFRSF13B
11 normal MP:0002873 9.86 CD19 CD40 CD84 IL10 IL4 TGFBR1
12 renal/urinary system MP:0005367 9.7 CCR1 CD19 CD40 CD40LG CR2 IL4
13 respiratory system MP:0005388 9.5 CCR1 CD81 IL10 IL4 LTA TGFBR1
14 skeleton MP:0005390 9.23 CD40 CD40LG CD81 IL10 IL4 LTA

Drugs & Therapeutics for Transient Hypogammaglobulinemia of Infancy

Search Clinical Trials , NIH Clinical Center for Transient Hypogammaglobulinemia of Infancy

Genetic Tests for Transient Hypogammaglobulinemia of Infancy

Anatomical Context for Transient Hypogammaglobulinemia of Infancy

MalaCards organs/tissues related to Transient Hypogammaglobulinemia of Infancy:

42
B Cells, T Cells

Publications for Transient Hypogammaglobulinemia of Infancy

Articles related to Transient Hypogammaglobulinemia of Infancy:

(show all 34)
# Title Authors Year
1
B lymphocyte subsets and outcomes in patients with an initial diagnosis of transient hypogammaglobulinemia of infancy. ( 30152873 )
2018
2
Decreased IgM, IgA, and IgG response to pneumococcal vaccine in children with transient hypogammaglobulinemia of infancy. ( 26233927 )
2016
3
Severe atopic dermatitis associated with transient hypogammaglobulinemia of infancy. ( 25600656 )
2015
4
Fcγ receptor polymorphisms in patients with transient hypogammaglobulinemia of infancy presenting with mild and severe infections. ( 26708396 )
2015
5
Transient hypogammaglobulinemia of infancy: predictive factors for late recovery. ( 27735798 )
2015
6
BCGitis in a patient with transient hypogammaglobulinemia of infancy. ( 23253103 )
2014
7
Reduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancy. ( 22820757 )
2013
8
B-cell subsets in patients with transient hypogammaglobulinemia of infancy, partial IgA deficiency, and selective IgM deficiency. ( 23654075 )
2013
9
The elevated number of circulating regulatory T cells in patients with transient hypogammaglobulinemia of infancy is not associated with any abnormalities in the genes encoding the TGF-β receptors. ( 23899993 )
2013
10
Does intravenous immunoglobulin therapy prolong immunodeficiency in transient hypogammaglobulinemia of infancy? ( 24198926 )
2013
11
The efficacy of Pelargonium sidoides in the treatment of upper respiratory tract infections in children with transient hypogammaglobulinemia of infancy. ( 22809962 )
2012
12
The number of circulating CD4+ CD25high Foxp3+ T lymphocytes is transiently elevated in the early childhood of transient hypogammaglobulinemia of infancy patients. ( 21531630 )
2011
13
Transient hypogammaglobulinemia of infancy: intravenous immunoglobulin as first line therapy. ( 20378022 )
2010
14
New laboratory findings in Turkish patients with transient hypogammaglobulinemia of infancy. ( 21131704 )
2010
15
Massive empyema associated with transient hypogammaglobulinemia of infancy and IgA deficiency. ( 19399287 )
2009
16
A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: results from the Italian Primary Immunodeficiency Network. ( 18547478 )
2008
17
Atopic dermatitis and transient hypogammaglobulinemia of infancy improved simultaneously. ( 17532847 )
2007
18
Impaired specific antibody response and increased B-cell population in transient hypogammaglobulinemia of infancy. ( 17165264 )
2006
19
Transient hypogammaglobulinemia of infancy presenting as Staphylococcus aureus sepsis with deep neck infection. ( 15843860 )
2005
20
Transient hypogammaglobulinemia of infancy and early childhood: outcome of 30 cases. ( 15214739 )
2004
21
Transient hypogammaglobulinemia of infancy: clinical and immunologic features of 40 new cases. ( 11192522 )
2000
22
X-linked agammaglobulinemia presenting as transient hypogammaglobulinemia of infancy. ( 7722175 )
1995
23
Transient hypogammaglobulinemia of infancy. ( 2264470 )
1990
24
Absent specific viral antibodies in patients with transient hypogammaglobulinemia of infancy. ( 2303650 )
1990
25
Transient hypogammaglobulinemia of infancy: Five new cases, review of the literature and redefinition. ( 2596283 )
1989
26
Transient hypogammaglobulinemia of infancy: need to reconsider name and definition. ( 3794886 )
1987
27
Transient hypogammaglobulinemia of infancy with severe bacterial infections and persistent IgA deficiency. ( 2427477 )
1986
28
Streptococcal sepsis presenting as acute abdomen in a child with transient hypogammaglobulinemia of infancy. ( 3540263 )
1986
29
Is transient hypogammaglobulinemia of infancy a manifestation of zinc deficiency? ( 6233190 )
1984
30
Transient hypogammaglobulinemia of infancy. ( 6977720 )
1982
31
Deficiency of T helper cells in transient hypogammaglobulinemia of infancy. ( 6270560 )
1981
32
Transient hypogammaglobulinemia of infancy. ( 75969 )
1978
33
Transient hypogammaglobulinemia of infancy: review of the literature, clinical and immunologic features of 11 new cases, and long-term follow-up. ( 632973 )
1978
34
Transient hypogammaglobulinemia of infancy. ( 908979 )
1977

Variations for Transient Hypogammaglobulinemia of Infancy

Expression for Transient Hypogammaglobulinemia of Infancy

Search GEO for disease gene expression data for Transient Hypogammaglobulinemia of Infancy.

Pathways for Transient Hypogammaglobulinemia of Infancy

Pathways related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 BTK CCR1 CD19 CD27 CD40 CD40LG
2
Show member pathways
13.7 BTK CCR1 CD27 CD40 CD40LG IL10
3
Show member pathways
13.4 BTK CCR1 CD27 CD40 CD40LG IL10
4
Show member pathways
13.24 CCR1 CD27 CD40 CD40LG IL10 IL4
5
Show member pathways
13.15 BTK CD19 CD40 CD81 CR2 IL4
6
Show member pathways
13.1 BTK CCR1 CD27 CD40 CD40LG IL10
7
Show member pathways
12.96 BTK CCR1 CD27 CD40 CD40LG IL10
8
Show member pathways
12.88 BTK CD27 CD40 CD40LG LTA TNFRSF13B
9
Show member pathways
12.82 CD40 CD40LG IL10 IL4 LTA TNFRSF13B
10
Show member pathways
12.64 CD27 CD40 CD40LG CR2 LTA
11
Show member pathways
12.58 BTK CD40 CD40LG IL10 IL4
12
Show member pathways
12.53 BTK CD19 CD81 CR2 IL4
13
Show member pathways
12.52 IL10 IL4 TGFBR1 TGFBR2
14 12.5 BTK CD19 CD40LG IL10 IL4
15
Show member pathways
12.47 BTK CD27 CD40 CD40LG LTA TNFRSF13B
16
Show member pathways
12.34 BTK CD19 CD81 CR2
17 12.31 CD40 LTA TGFBR1 TGFBR2
18
Show member pathways
12.21 CD40 CD40LG IL10 IL4
19
Show member pathways
12.19 IL10 IL4 LTA TGFBR1
20
Show member pathways
12.03 BTK IL10 IL4 TGFBR1 TGFBR2
21 12.02 CD19 CD40 CD40LG CD81
22
Show member pathways
11.99 IL10 LTA TGFBR1 TGFBR2
23 11.9 CCR1 CD19 IL10 IL4
24 11.84 CD19 CR2 IL4
25 11.78 BTK CD40 CD40LG LTA
26 11.74 IL10 IL4 LTA
27
Show member pathways
11.7 CD40 CD40LG TNFRSF13B
28 11.68 CD40 IL10 IL4
29 11.59 CD27 CD40 CD40LG
30 11.5 CD40LG IL10 IL4 LTA
31 11.49 CCR1 IL10 IL4
32 11.44 IL10 TGFBR1 TGFBR2
33 11.36 CD40 CD40LG CD81 IL10
34 11.26 CD40 CD40LG IL4
35 11.21 CD40 CD40LG IL4
36 11.2 CD27 LTA TNFRSF13B
37 11.1 IL10 IL4 LTA
38 11.06 BTK CD40LG IL10 IL4 LTA
39 11 BTK CD19 CD40 CD40LG TNFRSF13B UNG
40 10.97 BTK CD40LG IL10 IL4 LTA
41 10.95 CD19 CD27 CD40 CD40LG CD84 CR2

GO Terms for Transient Hypogammaglobulinemia of Infancy

Cellular components related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.97 BTK CCR1 CD19 CD27 CD40 CD40LG
2 cell surface GO:0009986 9.65 CD27 CD40 CD40LG TGFBR1 TGFBR2
3 external side of plasma membrane GO:0009897 9.43 CCR1 CD19 CD27 CD40 CD40LG TGFBR2
4 integral component of plasma membrane GO:0005887 9.32 CCR1 CD19 CD27 CD40 CD40LG CD81
5 membrane GO:0016020 10.17 BTK CCR1 CD19 CD27 CD40 CD40LG

Biological processes related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.95 CD27 CD40LG IL10 IL4 TGFBR1 UNG
2 immune response GO:0006955 9.85 CCR1 CD40LG CR2 IL10 IL4 LTA
3 regulation of complement activation GO:0030449 9.79 CD19 CD81 CR2
4 response to organic substance GO:0010033 9.77 BTK IL10 TGFBR2
5 cell surface receptor signaling pathway GO:0007166 9.73 CCR1 CD27 CD81 TNFRSF13B
6 regulation of immune response GO:0050776 9.72 CD19 CD40 CD40LG CD81 IL4
7 positive regulation of B cell proliferation GO:0030890 9.67 CD40 CD81 IL4
8 defense response to protozoan GO:0042832 9.64 CD40 IL10
9 positive regulation of T cell differentiation GO:0045582 9.63 CD27 IL4
10 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.63 TGFBR1 TGFBR2
11 B cell activation GO:0042113 9.63 BTK CD40 IL4
12 myeloid dendritic cell differentiation GO:0043011 9.62 IL4 TGFBR2
13 negative regulation of growth of symbiont in host GO:0044130 9.61 IL10 LTA
14 pathway-restricted SMAD protein phosphorylation GO:0060389 9.59 TGFBR1 TGFBR2
15 positive regulation of B cell differentiation GO:0045579 9.58 BTK CD27
16 positive regulation of isotype switching to IgG isotypes GO:0048304 9.58 CD40 IL4
17 response to cholesterol GO:0070723 9.57 TGFBR1 TGFBR2
18 positive regulation of MHC class II biosynthetic process GO:0045348 9.56 IL10 IL4
19 B cell differentiation GO:0030183 9.56 CD40LG CR2 IL10 IL4
20 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.55 TGFBR1 TGFBR2
21 regulation of immunoglobulin secretion GO:0051023 9.54 CD40 CD40LG
22 regulation of isotype switching GO:0045191 9.52 IL10 IL4
23 type 2 immune response GO:0042092 9.51 IL10 IL4
24 negative regulation of interleukin-18 production GO:0032701 9.4 CD84 IL10
25 negative regulation of B cell proliferation GO:0030889 9.33 BTK IL10 TNFRSF13B
26 B cell proliferation GO:0042100 9.26 CD40 CD40LG CR2 IL10
27 tumor necrosis factor-mediated signaling pathway GO:0033209 9.02 CD27 CD40 CD40LG LTA TNFRSF13B
28 immune system process GO:0002376 10 BTK CD40 CD84 CR2 TNFRSF13B

Molecular functions related to Transient Hypogammaglobulinemia of Infancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.55 BTK CCR1 CD19 CD27 CD40 CD40LG
2 transforming growth factor beta-activated receptor activity GO:0005024 9.26 TGFBR1 TGFBR2
3 cytokine activity GO:0005125 9.26 CD40LG IL10 IL4 LTA
4 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.16 TGFBR1 TGFBR2

Sources for Transient Hypogammaglobulinemia of Infancy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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