DMTN
MCID: TRN032
MIFTS: 41
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Transient Neonatal Diabetes Mellitus (DMTN)
Categories:
Endocrine diseases, Fetal diseases, Genetic diseases, Metabolic diseases, Rare diseases
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MalaCards integrated aliases for Transient Neonatal Diabetes Mellitus:
Characteristics:Orphanet epidemiological data:58
transient neonatal diabetes mellitus
Inheritance: Autosomal dominant,Autosomal recessive,Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Antenatal,Neonatal; Classifications:
MalaCards categories:
Global: Rare diseases Metabolic diseases Genetic diseases Fetal diseases Anatomical: Endocrine diseases
ICD10:
32
33
Orphanet: 58
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NIH Rare Diseases :
52
Transient neonatal diabetes mellitus (TNDB) is a type of diabetes that appears within the first few weeks of life but is transient; affected infants go into remission within a few months, with possible relapse to permanent diabetes in adolescence or adulthood. Affected individuals have slow growth before birth followed by hyperglycemia , dehydration and failure to thrive in infancy. Approximately 70% of cases are caused by the overactivity of certain genes in a region of the long (q) arm of chromosome 6 called 6q24. These cases are referred to as 6q24-related TNDB ; most (but not all) of these cases are not inherited . Other genetic causes include mutations in the KCNJ11 and ABCC8 genes, which usually cause permanent neonatal diabetes . Treatment may include rehydration and intravenous insulin at the time of diagnosis, followed by subcutaneous insulin.
MalaCards based summary : Transient Neonatal Diabetes Mellitus, also known as diabetes mellitus, transient neonatal, is related to diabetes mellitus, 6q24-related transient neonatal and diabetes mellitus, transient neonatal, 1. An important gene associated with Transient Neonatal Diabetes Mellitus is HYMAI (Hydatidiform Mole Associated And Imprinted), and among its related pathways/superpathways are Integration of energy metabolism and Type II diabetes mellitus. Affiliated tissues include heart, pancreatic islet and testes, and related phenotypes are failure to thrive and dehydration Disease Ontology : 12 A neonatal diabetes mellitus characterized by hyperglycemia during the neonatal period that remits during infancy but recurs in later life in most patients. KEGG : 36 Neonatal diabetes mellitus (NDM), which is a monogenic form of diabetes, is a heterogeneous group of disorders characterized by hyperglycemia in the first 6 months of life. NDM is categorized into transient (TNDM) and permanent (PNDM). TNDM is a developmental disorder of insulin production that resolves by age 18 months but can reappear later in life. TNDM is different from type 1 diabetes since no islet cell antibodies or autoimmune phenomenon were found in these patients. 6q24-related TNDM is an imprinting disorder resulting from overexpression of at least two imprinted genes, PLAGL1 and HYMAI, on chromosome 6q24. Hypomethylation of multiple imprinted loci is associated with mutations in ZFP57. Mutations in ABCC8 and KCNJ11 encoding Kir6.2 and SUR1 are other genetic causes of TNDM. Wikipedia : 74 Transient neonatal diabetes mellitus (TNDM) is a form of neonatal diabetes presenting at birth that is... more... |
Human phenotypes related to Transient Neonatal Diabetes Mellitus:58 31 (show all 33)
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MalaCards organs/tissues related to Transient Neonatal Diabetes Mellitus:40
Heart,
Pancreatic Islet,
Testes,
Pancreas,
Skeletal Muscle,
Placenta
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Articles related to Transient Neonatal Diabetes Mellitus:(show top 50) (show all 205)
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Search
GEO
for disease gene expression data for Transient Neonatal Diabetes Mellitus.
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Cellular components related to Transient Neonatal Diabetes Mellitus according to GeneCards Suite gene sharing:
Biological processes related to Transient Neonatal Diabetes Mellitus according to GeneCards Suite gene sharing:
Molecular functions related to Transient Neonatal Diabetes Mellitus according to GeneCards Suite gene sharing:
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